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Articles 54031 - 54060 of 294570

Full-Text Articles in Physical Sciences and Mathematics

The Necessity Of Cloud-Based Simulator For Indonesia's Maritime Education And Training Institutions, Stevian Geerbel Adrianes Rakka Oct 2022

The Necessity Of Cloud-Based Simulator For Indonesia's Maritime Education And Training Institutions, Stevian Geerbel Adrianes Rakka

World Maritime University Dissertations

No abstract provided.


Exploration Of Occupational Safety And Health In Pakistan's Ship Breaking And Recycling Industry, Shehzad Akbar Oct 2022

Exploration Of Occupational Safety And Health In Pakistan's Ship Breaking And Recycling Industry, Shehzad Akbar

World Maritime University Dissertations

No abstract provided.


Selection Of The Optimal Alternative Fuel In Terms Of The Sustainability Of The Shipping Industry Through The Multi-Attribute Decision Making, Kyungrok Kim Oct 2022

Selection Of The Optimal Alternative Fuel In Terms Of The Sustainability Of The Shipping Industry Through The Multi-Attribute Decision Making, Kyungrok Kim

World Maritime University Dissertations

No abstract provided.


A Safety Analysis On The Potential Risks Onboard Ships That Would Use Ammonia As Marine Fuel, Praveen Raghavan Nair Oct 2022

A Safety Analysis On The Potential Risks Onboard Ships That Would Use Ammonia As Marine Fuel, Praveen Raghavan Nair

World Maritime University Dissertations

No abstract provided.


The Feasibility Of Utilizing Hydrogen Fuel Cell, Wind, And Solar Power On Bulk Carrier For Propulsion, Saeid Hassankhani Dolatabadi Oct 2022

The Feasibility Of Utilizing Hydrogen Fuel Cell, Wind, And Solar Power On Bulk Carrier For Propulsion, Saeid Hassankhani Dolatabadi

World Maritime University Dissertations

No abstract provided.


Monitoring Activities Of Daily Living For Maintaining Independent Living In Dementia, Jonathan Turner, Ciaran Nugent, Damon Berry, Dympna O'Sullivan, Michael Wilson, Julie Doyle Oct 2022

Monitoring Activities Of Daily Living For Maintaining Independent Living In Dementia, Jonathan Turner, Ciaran Nugent, Damon Berry, Dympna O'Sullivan, Michael Wilson, Julie Doyle

Articles

Our ability to live independent meaningful lives depends on our ability to perform various activities and to maintain our cognitive functions. Maintaining independent living is important for persons with dementia, it increases selfworth and allows to remain independent and in their own homes for longer. We describe the activities established as being important for the maintenance of independent living, and methods for monitoring these activities using technology.


Study Of Multilayer Flow Of A Bi-Viscous Bingham Fluid Sandwiched Between Hybrid Nanofluid In A Vertical Slab With Nonlinear Boussinesq Approximation, Mahanthesh Basavarajappa, Shruthy Myson, Kuppalapalle Vajravelu Oct 2022

Study Of Multilayer Flow Of A Bi-Viscous Bingham Fluid Sandwiched Between Hybrid Nanofluid In A Vertical Slab With Nonlinear Boussinesq Approximation, Mahanthesh Basavarajappa, Shruthy Myson, Kuppalapalle Vajravelu

School of Mathematical & Statistical Sciences Faculty Publications

Bi-Viscosity Bingham plastic fluids are used to understand the rheological characteristics of pigment-oil suspensions, polymeric gels, emulsions, heavy oil, etc. High-temperature applications in many industrial and engineering problems, linear density-temperature variation is inadequate to describe convective heat transport. Therefore, the characteristics of the nonlinear convective flow of a Bi-Viscosity Bingham Fluid (BVBF) through three layers in a vertical slab are studied. The two outer layers of the oil-based hybrid nanofluid and the intermediate layer of BVBF are considered. The thermal buoyancy force is governed by the nonlinear Boussinesq approximation. Continuity of heat flux, velocity, shear stress, and temperature are imposed …


11th International Conference On Business, Technology And Innovation 2022, University For Business And Technology - Ubt Oct 2022

11th International Conference On Business, Technology And Innovation 2022, University For Business And Technology - Ubt

UBT International Conference

Welcome to IC – UBT 2022

UBT Annual International Conference is the 11th international interdisciplinary peer reviewed conference which publishes works of the scientists as well as practitioners in the area where UBT is active in Education, Research and Development. The UBT aims to implement an integrated strategy to establish itself as an internationally competitive, research-intensive university, committed to the transfer of knowledge and the provision of a world-class education to the most talented students from all background. The main perspective of the conference is to connect the scientists and practitioners from different disciplines in the same place and make …


Incoherent And Online Dictionary Learning Algorithm For Motion Prediction, Farrukh Hafeez, Usman Ullah Sheikh, Asif Iqbal, Muhammad Naveed Aman Oct 2022

Incoherent And Online Dictionary Learning Algorithm For Motion Prediction, Farrukh Hafeez, Usman Ullah Sheikh, Asif Iqbal, Muhammad Naveed Aman

School of Computing: Faculty Publications

Accurate model development and efficient representations of multivariate trajectories are crucial to understanding the behavioral patterns of pedestrian motion. Most of the existing algorithms use offline learning approaches to learn such motion behaviors. However, these approaches cannot take advantage of the streams of data that are available after training has concluded, and typically are not generalizable to data that they have not seen before. To solve this problem, this paper proposes two algorithms for learning incoherent dictionaries in an offline and online manner by extending the offline augmented semi-non-negative sparse coding (ASNSC) algorithm. We do this by adding a penalty …


Mgrre_Thinsections_05_A_65, Mgrre Oct 2022

Mgrre_Thinsections_05_A_65, Mgrre

Thin Sections

No abstract provided.


A New Wave Of “Space Nationalism” In The United States: Why Are Evangelicals Good With It?, Andrea Molle Oct 2022

A New Wave Of “Space Nationalism” In The United States: Why Are Evangelicals Good With It?, Andrea Molle

Political Science Faculty Articles and Research

Despite evidence that shows how the support for space programs correlates with liberal political views and a lower level of religiosity, recent data suggest that more conservative positions may have an even more substantial effect under the appropriate conditions. Using the available data from Pew's American Trends Panel, we seek to clarify this interactional effect of political and religious preferences on the level of interest in the space programs and commitment to space politics support among Evangelicals as it changed during Trump's presidency. Our research hypothesizes that during this time, the simultaneous presence of nationalist views in both accounts of …


The Spectral Picture And Joint Spectral Radius Of The Generalized Spherical Aluthge Transform, Chafiq Benhida, Raul E. Curto, Sang Hoon Lee, Jasang Yoon Oct 2022

The Spectral Picture And Joint Spectral Radius Of The Generalized Spherical Aluthge Transform, Chafiq Benhida, Raul E. Curto, Sang Hoon Lee, Jasang Yoon

School of Mathematical & Statistical Sciences Faculty Publications

For an arbitrary commuting d--tuple $\bT$ of Hilbert space operators, we fully determine the spectral picture of the generalized spherical Aluthge transform $\dbT$ and we prove that the spectral radius of $\bT$ can be calculated from the norms of the iterates of $\dbT$. \ Let $\bm{T} \equiv (T_1,\cdots,T_d)$ be a commuting d--tuple of bounded operators acting on an infinite dimensional separable Hilbert space, let P:=T∗1T1+⋯+T∗dTd−−−−−−−−−−−−−−−√, and let ⎛⎝⎜⎜T1⋮Td⎞⎠⎟⎟=⎛⎝⎜⎜V1⋮Vd⎞⎠⎟⎟P be the canonical polar decomposition, with (V1,⋯,Vd) a (joint) partial isometry and ⋂i=1dkerTi=⋂i=1dkerVi=kerP. \medskip For 0≤t≤1, we define the generalized spherical Aluthge transform of $\bm{T}$ by \Delta_t(\bm{T}):=(P^t V_1P^{1-t}, \cdots, P^t V_dP^{1-t}). We …


Design Of Possible Organic Photovoltaic Compounds And Their Initial Computational Assessment, Albert Ochoa Castillo, Joshua Smith Oct 2022

Design Of Possible Organic Photovoltaic Compounds And Their Initial Computational Assessment, Albert Ochoa Castillo, Joshua Smith

IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt

The excessive use of fossil fuels has surged the need for alternative energy sources, such as solar energy. Organic photovoltaic (OPV) cells can potentially be an alternative to silicon solar cells. OPV compounds are carbon-based and use organic electronics as a semiconductor to produce electricity from the sun. There is a large interest in OPV cells because they are strong absorbers and come at a low cost of synthesis. Herein, possible OPV compounds were designed, and theoretical computations were done to assess their efficiency. Density Functional Theory was used to calculate the HOMO-LUMO gap of the compounds designed. Semiconductors such …


Concentration Of Heavy Metals In Three Distinct Algae Families From Humboldt County, California, Kodiak E. Miller, Caleb J. Strait, Jacob I. Begorre, Brittney L. Mitchell, Claire P. Till Oct 2022

Concentration Of Heavy Metals In Three Distinct Algae Families From Humboldt County, California, Kodiak E. Miller, Caleb J. Strait, Jacob I. Begorre, Brittney L. Mitchell, Claire P. Till

IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt

Anthropogenic impacts on marine environments can impact metal fluxes and concentrations available to marine species. Monitoring these impacts is necessary to better understand the interactions between the biotic and abiotic components of these ecosystems and mitigate the risk posed by harmful toxins introduced by human activities. Biomoniters, like macroscopic algae, are useful indicators that illuminate the bioaccumulation of toxins commonly introduced from anthropogenic activity. With this in mind, the concentrations of heavy metals zinc (Zn), nickel (Ni), and copper (Cu) were analyzed via the assessment of algae (Representatives from Ulva, Mastocarpus, Fucus) in two sites in Humboldt County: …


Highlighting The Disconnect Between Legislation And Sustainable Cannabis, Johnathon A. Macias Oct 2022

Highlighting The Disconnect Between Legislation And Sustainable Cannabis, Johnathon A. Macias

IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt

Current legislation takes little regard for two major issues challenging the cannabis industry. The carbon footprint and legislation of cannabis are looked at where it is realized that neither is currently sustainable long-term. Solutions that require social responsibility from the legislation to preserve the culture and industry are delved into.


Identification Of Disease Resistance Parents And Genome-Wide Association Mapping Of Resistance In Spring Wheat, Muhammad Iqbal, Kassa Semagn, Diego Jarquin, Harpinder Randhawa, Brent D. Mccallum, Reka Howard, Reem Aboukhaddour, Izabela Ciechanowska, Klaus Strenzke, José Crossa, J. Jesus Céron-Rojas, Amidou N’Diaye, Curtis Pozniak, Dean Spaner Oct 2022

Identification Of Disease Resistance Parents And Genome-Wide Association Mapping Of Resistance In Spring Wheat, Muhammad Iqbal, Kassa Semagn, Diego Jarquin, Harpinder Randhawa, Brent D. Mccallum, Reka Howard, Reem Aboukhaddour, Izabela Ciechanowska, Klaus Strenzke, José Crossa, J. Jesus Céron-Rojas, Amidou N’Diaye, Curtis Pozniak, Dean Spaner

Department of Statistics: Faculty Publications

The likelihood of success in developing modern cultivars depend on multiple factors, including the identification of suitable parents to initiate new crosses, and characterizations of genomic regions associated with target traits. The objectives of the present study were to (a) determine the best economic weights of four major wheat diseases (leaf spot, common bunt, leaf rust, and stripe rust) and grain yield for multi-trait restrictive linear phenotypic selection index (RLPSI), (b) select the top 10% cultivars and lines (hereafter referred as genotypes) with better resistance to combinations of the four diseases and acceptable grain yield as potential parents, and (c) …


Machine Learning For Aiding Blood Flow Velocity Estimation Based On Angiography, Swati Padhee, Mark Johnson, Hang Yi, Tanvi Banerjee, Zifeng Yang Oct 2022

Machine Learning For Aiding Blood Flow Velocity Estimation Based On Angiography, Swati Padhee, Mark Johnson, Hang Yi, Tanvi Banerjee, Zifeng Yang

Computer Science and Engineering Faculty Publications

Computational fluid dynamics (CFD) is widely employed to predict hemodynamic characteristics in arterial models, while not friendly to clinical applications due to the complexity of numerical simulations. Alternatively, this work proposed a framework to estimate hemodynamics in vessels based on angiography images using machine learning (ML) algorithms. First, the iodine contrast perfusion in blood was mimicked by a flow of dye diffusing into water in the experimentally validated CFD modeling. The generated projective images from simulations imitated the counterpart of light passing through the flow field as an analogy of X-ray imaging. Thus, the CFD simulation provides both the ground …


Novel Thioglycosides As Versatile Glycosyl Donors For Oligosaccharide Synthesis, Ganesh Shrestha Oct 2022

Novel Thioglycosides As Versatile Glycosyl Donors For Oligosaccharide Synthesis, Ganesh Shrestha

Dissertations

This thesis is dedicated to the development of new methodologies for efficient synthesis of carbohydrate building blocks and their application to chemical glycosylation. S-Indolyl (SIn) anomeric moiety was investigated as a new leaving group. Understanding of the reaction pathways for the SIn moiety activation was achieved via the extended mechanistic study. The activation profile of indolylthio glycosides required large excess of activators. This drawback was partially addressed by the development of N-alkylated SInR derivatives. The activation process was studied by NMR and the increased understanding of the mechanism led to a discovery of different activation pathways taking place with …


Mgrre_Thinsections_05_A_64, Mgrre Oct 2022

Mgrre_Thinsections_05_A_64, Mgrre

Thin Sections

No abstract provided.


How Dynamic Adsorption Controls Surfactant‑Enhanced Boiling, Mario R. Mata, Brandon Ortiz, Dhruv Luhar, Vesper Evereux, H. Jeremy Cho Oct 2022

How Dynamic Adsorption Controls Surfactant‑Enhanced Boiling, Mario R. Mata, Brandon Ortiz, Dhruv Luhar, Vesper Evereux, H. Jeremy Cho

Mechanical Engineering Faculty Research

Improving boiling is challenging due to the unpredictable nature of bubbles. One way to enhance boiling is with surfactants, which alter the solid–liquid and liquid–vapor interfaces. The conventional wisdom established by previous studies suggests that heat transfer enhancement is optimized near the critical micelle concentration (CMC), which is an equilibrium property that depends on surfactant type. However, these studies only tested a limited number of surfactants over small concentration ranges. Here, we test a larger variety of nonionic and anionic surfactants over the widest concentration range and find that a universal, optimal concentration range exists, irrespective of CMC. To explain …


Evaluating The Effect Of Woodchips On Soil Matric Potential, Temperature, Weed Biomass, And Yield Of Selected Crops, Leonard Githinji, Patrick Johnson Oct 2022

Evaluating The Effect Of Woodchips On Soil Matric Potential, Temperature, Weed Biomass, And Yield Of Selected Crops, Leonard Githinji, Patrick Johnson

Professional Agricultural Workers Journal

Organic mulches are very popular for weed control in sustainable agricultural systems where the application of synthetic herbicides is restricted. A study was conducted to evaluate the effectiveness of organic mulch in controlling weeds, enhancing soil matric potential, and soil temperature. Blended hardwood mulch was applied to the soil surface at a thickness of 10 cm. The experimental design was laid out as a completely randomized design with two treatments, viz., mulch and no-mulch, replicated 5 times. Data were collected during the growing period for weed biomass, soil matric potential, soil temperature, and yield of selected crops. Results from a …


Exploring The Vulnerability Of A Neural Tangent Generalization Attack (Ntga) - Generated Unlearnable Cifar-10 Dataset, Gitte Ost Oct 2022

Exploring The Vulnerability Of A Neural Tangent Generalization Attack (Ntga) - Generated Unlearnable Cifar-10 Dataset, Gitte Ost

USF Tampa Graduate Theses and Dissertations

Nowadays, a massive amount of data is generated and stored on servers and cloudsfrom various applications daily. Preventing these data from unauthorized use often becomes necessary and critical in various real-world applications. Many researchers have studied this crucial problem and developed different methods for this purpose. Among them, Neural Tangent Generalization Attack (NTGA) is one of the most efficient methods to make a dataset unlearnable, which means that the dataset is not learnable by machine learning/deep learning methods. That is, the NTGA-generated dataset is protected against unauthorized use. In this thesis, we explore the vulnerability of an NTGA-generated unlearnable CIFAR-10 …


Further Comments On "Engineering Shape Anisotropy Of Fe3o4-Γ-Fe2o3hollow Nanoparticles For Magnetic Hyperthermia", Fernande Grandjean, Gary J. Long Oct 2022

Further Comments On "Engineering Shape Anisotropy Of Fe3o4-Γ-Fe2o3hollow Nanoparticles For Magnetic Hyperthermia", Fernande Grandjean, Gary J. Long

Chemistry Faculty Research & Creative Works

In their earlier paper, Niraula et al. (ACS Appl. Nano Mater. 2021, 4, 3148-3158) described the morphological, compositional, and magnetic properties of three different magnetite/maghemite or Fe3O4/γ-Fe2O3, hollow nanoparticles, referred to herein as nanorings, short-nanotubes, and long-nanotubes. Scanning electron microscopy indicates that these nanoparticles have lengths of 275 ± 51, 411 ± 92, and 515 ± 98 nm and outer diameters of 201 ± 55, 251 ± 46, and 229 ± 42 nm, respectively, dimensions that are all rather similar in view of their distributions, as is shown in a figure herein. …


Electrochemical Syntheses Of Nanomaterials And Small Molecules For Electrolytic Hydrogen Production, Jia-Qi Wei, Xiao-Dong Chen, Shu-Zhou Li Oct 2022

Electrochemical Syntheses Of Nanomaterials And Small Molecules For Electrolytic Hydrogen Production, Jia-Qi Wei, Xiao-Dong Chen, Shu-Zhou Li

Journal of Electrochemistry

Hydrogen is a clean, efficient, renewable energy resource and the most promising alternative to fossil fuels for future carbon-neutral energy supply. Therefore, sustainable hydrogen production is highly attractive and urgently demanded, especially via water electrolysis that has clean, abundant precursors and zero emission. However, current water electrolysis is hindered by the sluggish kinetics and low cost/energy efficiency of both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). In this regard, electrochemical synthesis offers prospects to raise the efficiency and benefit of water electrolysis by fabricating advanced electrocatalysts and providing more efficient/value-adding co-electrolysis alternatives. It is an eco-friendly and facile …


Catalytic Effect Of Disordered Ru-O Configurations For Electrochemical Hydrogen Evolution, Xue Sun, Ya-Jie Song, Ren-Long Li, Jia-Jun Wang Oct 2022

Catalytic Effect Of Disordered Ru-O Configurations For Electrochemical Hydrogen Evolution, Xue Sun, Ya-Jie Song, Ren-Long Li, Jia-Jun Wang

Journal of Electrochemistry

Phase engineering is considered as an effective method for modulating the electronic structure and catalytic activity of catalysts. The disordered conformation of amorphous materials allows flexible reforming of the surface electronic structure, showing their attractiveness as catalysts for hydrogen evolution reaction (HER). Herein, we designed and developed an amorphous ruthenium dioxide (a-RuO2) catalyst with a disordered Ru-O configuration. The conformational relationship between Ru-O ordering and HER performance is established by combining advanced electron microscopic techniques with detailed electrochemical tests. Specifically, the disordered Ru-O coordination significantly enhanced the HER catalytic activity in both acidic and alkaline media, ultimately leading …


Mobility-Aware Hierarchical Fog Computing Framework For Industrial Internet Of Things (Iiot), Tariq Qayyum, Zouheir Trabelsi, Asad Waqar Malik, Kadhim Hayawi Oct 2022

Mobility-Aware Hierarchical Fog Computing Framework For Industrial Internet Of Things (Iiot), Tariq Qayyum, Zouheir Trabelsi, Asad Waqar Malik, Kadhim Hayawi

All Works

The Industrial Internet of Things (IIoTs) is an emerging area that forms the collaborative environment for devices to share resources. In IIoT, many sensors, actuators, and other devices are used to improve industrial efficiency. As most of the devices are mobile; therefore, the impact of mobility can be seen in terms of low-device utilization. Thus, most of the time, the available resources are underutilized. Therefore, the inception of the fog computing model in IIoT has reduced the communication delay in executing complex tasks. However, it is not feasible to cover the entire region through fog nodes; therefore, fog node selection …


A Self-Supported Ru-Cu3P Catalyst Toward Alkaline Hydrogen Evolution, Zi-Xuan Wan, Chao-Hui Wang, Xiong-Wu Kang Oct 2022

A Self-Supported Ru-Cu3P Catalyst Toward Alkaline Hydrogen Evolution, Zi-Xuan Wan, Chao-Hui Wang, Xiong-Wu Kang

Journal of Electrochemistry

Transition metal phosphide (TMP) is a kind of effective catalysts toward hydrogen evolution reaction (HER) in alkaline electrolytes. However, the performance of TMP catalysts is strongly limited by water splitting. In this work, we developed a method to prepare a copper foam (CF) supported Ru-doped Cu3P catalyst (Ru-Cu3P/CF) by a consecutive growth of Cu(OH)2 nanoarrays, soaking in RuCl3 solution and phosphorization. A large surface area was obtained by the self-supported catalysts with the appropriative Ru doping. As an excellent HER catalyst, it exhibited a low overpotential of 95.6 mV at a current density of …


The Detection Of Periodic Reemergence Events Of Sars-Cov-2 Delta Strain In Communities Dominated By Omicron., Claire E. Westcott, Kevin J. Sokoloski, Eric C. Rouchka, Julia H. Chariker, Rochelle H. Holm, Ray A. Yeager, Joseph B. Moore Iv, Erin M. Elliott, Daymond Talley, Aruni Bhatnagar Oct 2022

The Detection Of Periodic Reemergence Events Of Sars-Cov-2 Delta Strain In Communities Dominated By Omicron., Claire E. Westcott, Kevin J. Sokoloski, Eric C. Rouchka, Julia H. Chariker, Rochelle H. Holm, Ray A. Yeager, Joseph B. Moore Iv, Erin M. Elliott, Daymond Talley, Aruni Bhatnagar

Faculty and Staff Scholarship

Despite entering an endemic phase, SARS-CoV-2 remains a significant burden to public health across the global community. Wastewater sampling has consistently proven utility to understanding SARS-CoV-2 prevalence trends and genetic variation as it represents a less biased assessment of the corresponding communities. Here, we report that ongoing monitoring of SARS-CoV-2 genetic variation in samples obtained from the wastewatersheds of the city of Louisville in Jefferson county Kentucky has revealed the periodic reemergence of the Delta strain in the presence of the presumed dominant Omicron strain. Unlike previous SARS-CoV-2 waves/emergence events, the Delta reemergence events were geographically restricted in the community …


Alkaline Water Electrolysis For Efficient Hydrogen Production, Wen-Fu Xie, Ming-Fei Shao Oct 2022

Alkaline Water Electrolysis For Efficient Hydrogen Production, Wen-Fu Xie, Ming-Fei Shao

Journal of Electrochemistry

Hydrogen production from water electrolysis is a sustainable and environmentally benign strategy in comparison with fossil fuel-based hydrogen. However, this promising technique suffers from the high energy consumption and unsatisfactory cost due to the sluggish kinetics of both half reaction and inferior stability of electrocatalysts. To address this challenge, herein, we present a timely and comprehensive review on advances in alkaline water electrolysis that is already commercialized for large scale hydrogen production. The design principles and strategies with aiming to promote the performance of hydrogen generation are discussed from the view of electrocatalyst, electrode, reaction and system. The challenges and …


Alkaline Seawater Electrolysis At Industrial Level:Recent Progress And Perspective, Tao Zhang, Yi-Pu Liu, Qi-Tong Ye, Hong-Jin Fan Oct 2022

Alkaline Seawater Electrolysis At Industrial Level:Recent Progress And Perspective, Tao Zhang, Yi-Pu Liu, Qi-Tong Ye, Hong-Jin Fan

Journal of Electrochemistry

Industrial hydrogen generation through water splitting, powered by renewable energy such as solar, wind and marine, paves a potential way for energy and environment sustainability. However, state-of-the-art electrolysis using high purity water as hydrogen source at an industrial level would bring about crisis of freshwater resource. Seawater splitting provides a practical path to solve potable water shortage, but still faces great challenges for large-scale industrial operation. Here we summarize recent developments in seawater splitting, covering general mechanisms, design criteria for electrodes, and industrial electrolyzer for direct seawater splitting. Multi-objective optimization methods to address the key challenges of active sites, reaction …