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Articles 38431 - 38460 of 294391

Full-Text Articles in Physical Sciences and Mathematics

Isolation Of Lignin From Sugarcane Bagasse As An Adsorbent For Chromium Ion, Nila Tanyela Berghuis, Nurul Fitri Novianti, Paramita Jaya Ratri Sep 2023

Isolation Of Lignin From Sugarcane Bagasse As An Adsorbent For Chromium Ion, Nila Tanyela Berghuis, Nurul Fitri Novianti, Paramita Jaya Ratri

Makara Journal of Science

The waste generated in metal coating and leather tanning industries contribute to water pollution owing to the use of Cr metal in production processes. The utilization of lignin from natural base materials in the form of bagasse can reduce unwanted waste from production processes and adsorb Cr ion waste. In this study, lignin was successfully isolated from bagasse waste and then carbonized and applied in Cr metal absorption. Lignin and lignin carbon as an absorbent were characterized using Fourier-transform infrared spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The ability of bagasse lignin and carbon lignin to absorb Cr ion waste …

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Antibacterial Testing On Silver/Zinc Oxide Nanoparticles/Organoclay Reinforced Chitosan Biocomposites, Lisna Junaeni Muiz, Ariadne Lakshmidevi Juwono, Zulkarnaen Paputungan, Yuni Krisyuningsih Krisnandi Sep 2023

Antibacterial Testing On Silver/Zinc Oxide Nanoparticles/Organoclay Reinforced Chitosan Biocomposites, Lisna Junaeni Muiz, Ariadne Lakshmidevi Juwono, Zulkarnaen Paputungan, Yuni Krisyuningsih Krisnandi

Makara Journal of Science

Herein, bionanocomposites of chitosan (CS)/silver nanoparticle/organoclay/zinc oxide nanoparticle (CS/Ag/OC/ZnO) were prepared for antibacterial food packaging. This study examines the time variation in the AgNP synthesis method by comparing local (74˗85% deacetylated) and commercial chitosan (75%˗85% deacetylated) as a reducing and capping agent and seeks to reconstruct the optimum ratio formulations of AgNPs and ZnONPs in bionanocomposites for food packaging. The results reveal that the synthesis of AgNPs was successfully carried out using a local chitosan solution as a reducing and capping agent. The CS/Ag/OC/ZnO films exhibit structural, mechanical, and optical properties suitable for food packaging and antibacterial activity on Staphylococcus …

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Chicken Immune Responses To Vaccination By The Avian Influenza Subtype H5n1 Against Avian Influenza, Ramlah Ramlah, Sri Murtini, Retno Damayanti Soejoedono, Ketut Karuni Nyanakumari Natih, Siti Gusti Ningrum Sep 2023

Chicken Immune Responses To Vaccination By The Avian Influenza Subtype H5n1 Against Avian Influenza, Ramlah Ramlah, Sri Murtini, Retno Damayanti Soejoedono, Ketut Karuni Nyanakumari Natih, Siti Gusti Ningrum

Makara Journal of Science

Avian Influenza (AI) is one of the strategic animal diseases still considered a priority for control by the Indonesian government. This study aimed to examine the immune response of chickens to various types of H5N1 subtype AI vaccines in Indonesia and to determine the correlation of factors influencing the post-vaccination AI antibody response. Serum samples were tested using the hemagglutination inhibition (HI) test with the standard AI antigen subtype H5N1 strain A/Chicken/Barru/BBVM/41-13/2013 (Clade 2.1.3) and strain A/Chicken/Semarang/04141225-07/2014 (Clade 2.3.2). Antibody titer was calculated using the Geometric Mean Titer (GMT). The correlation analyses were performed to assess the correlation of antibody …

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A Deep Learning-Based Object Detection Framework For Automatic Asphalt Pavement Patch Detection Using Laser Profiling Images, Ibrahim Hassan Syed, Susan Mckeever Dr., Kieran Feighan, David Power, Dympna O'Sullivan Sep 2023

A Deep Learning-Based Object Detection Framework For Automatic Asphalt Pavement Patch Detection Using Laser Profiling Images, Ibrahim Hassan Syed, Susan Mckeever Dr., Kieran Feighan, David Power, Dympna O'Sullivan

Conference papers

Road maintenance and the early detection of road defects rely on routine pavement inspections. While advanced 3D laser profiling systems have the capability to automatically identify certain types of distress such as cracks and ruts, more complex pavement damage, including patches, often require manual identification. To address this limitation, this study proposes an automated patch detection system that employs object detection techniques. The results demonstrate the ability of object detection models to accurately identify patches in laser profiling images, indicating that the proposed approach has the capability to significantly enhance automation in visual inspection processes. This has the potential for …

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Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) 2023 Final Unreclaimed Sites Quality Assurance Project Plan And Bpsou 2023 Final Insufficiently Reclaimed Sites Quality Assurance Project Plan; Rfc 2023-02 (Dated September 18, 2023), Nikia Greene Sep 2023

Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) 2023 Final Unreclaimed Sites Quality Assurance Project Plan And Bpsou 2023 Final Insufficiently Reclaimed Sites Quality Assurance Project Plan; Rfc 2023-02 (Dated September 18, 2023), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

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Residential Metals Abatement Program Investigation Summary Report (Non-Residential Parcels – Indoor Dust) East Middle School, Environmental Resource Management (Erm) Sep 2023

Residential Metals Abatement Program Investigation Summary Report (Non-Residential Parcels – Indoor Dust) East Middle School, Environmental Resource Management (Erm)

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

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Why Interference Phenomena Do Not Capture The Essence Of Quantum Theory, Lorenzo Catani, Matthew Leifer, David Schmid, Robert W. Spekkens Sep 2023

Why Interference Phenomena Do Not Capture The Essence Of Quantum Theory, Lorenzo Catani, Matthew Leifer, David Schmid, Robert W. Spekkens

Mathematics, Physics, and Computer Science Faculty Articles and Research

Quantum interference phenomena are widely viewed as posing a challenge to the classical worldview. Feynman even went so far as to proclaim that they are the only mystery and the basic peculiarity of quantum mechanics. Many have also argued that basic interference phenomena force us to accept a number of radical interpretational conclusions, including: that a photon is neither a particle nor a wave but rather a Jekyll-and-Hyde sort of entity that toggles between the two possibilities, that reality is observerdependent, and that systems either do not have properties prior to measurements or else have properties that are subject to …

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Partnering For Climate Resilience: Exploring The Maturity Of Private-Sector Efforts In The Great Lakes Region, Lisa Greenwood, Yewande Abraham, Jennifer Schneider, Vicki Lin Sep 2023

Partnering For Climate Resilience: Exploring The Maturity Of Private-Sector Efforts In The Great Lakes Region, Lisa Greenwood, Yewande Abraham, Jennifer Schneider, Vicki Lin

Articles

Communities and businesses continue to experience the effects of climate change as global temperatures rise and extreme weather events become more frequent. In the United States (US), the public sector has traditionally been responsible for mitigating these risks; however, engaging the private sector is crucial, given industrial impacts on and vulnerability to climate change. Private-sector mitigation and adaptation efforts are critical in the Great Lakes Region due to aging infrastructure as well as its economic, environmental, and political importance in the US and Canada. This study explores private-sector resilience efforts in three Great Lakes cities to identify opportunities and trends …

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Energy-Aware Path Planning For Fixed-Wing Seaplane Uavs, Benjamin Atkinson Wolsieffer Sep 2023

Energy-Aware Path Planning For Fixed-Wing Seaplane Uavs, Benjamin Atkinson Wolsieffer

Dartmouth College Master’s Theses

Fixed-wing unmanned aerial vehicles (UAVs) are commonly used for remote sensing applications over water bodies, such as monitoring water quality or tracking harmful algal blooms. However, there are some types of measurements that are difficult to accurately obtain from the air. In existing work, water samples have been collected in situ either by hand, with an unmanned surface vehicle (USV), or with a vertical takeoff and landing (VTOL) UAV such as a multirotor. We propose a path planner, landing control algorithm, and energy estimator that will allow a low-cost and energy efficient fixed-wing UAV to carry out a combined remote …

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K-Long Identification Efficiency Of The Klm Detector In The Belle Ii Experiment Using Splot, Andrew J. Davis, Diptaparna Biswas, Swagato Banerjee Sep 2023

K-Long Identification Efficiency Of The Klm Detector In The Belle Ii Experiment Using Splot, Andrew J. Davis, Diptaparna Biswas, Swagato Banerjee

The Cardinal Edge

Long-lived neutral kaon mesons (neutral K-longs) are identified by energy deposits in the KLM detector of the Belle II experiment. However, various other particles can also deposit energy in the KLM detector. A statistical method known as sPlot can be utilized to distinguish between the energy deposit patterns of neutral K-longs vs. other backgrounds. This technique, currently developed with Monte-Carlo events, allows for a more robust determination of K-long identification efficiency in the KLM detector, which can eventually be applied on real data.

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Exploring Students’ Epistemological Understanding Of Atomic Structure Models, Claire V. Ward, Morgan Balabanoff Sep 2023

Exploring Students’ Epistemological Understanding Of Atomic Structure Models, Claire V. Ward, Morgan Balabanoff

The Cardinal Edge

Developing a robust understanding of atomic structure and the nature of matter is foundational across chemistry and STEM courses. The development of this concept is challenging because it relies on models to illustrate something not directly observable. Scientific models are important tools used to explain phenomena, particularly phenomena that are not directly observable. In general chemistry, students are typically asked to consider four different models: (1) the particle model, (2) the nuclear model, (3) the Bohr model, and (4) the Quantum model. Each depiction has its own advantages and limitations, where instructors introduce each model to explain specific parts of …

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Characterization And Electrolysis Of Zn And Cu 2,6-Diacetylpyridine Bis(2-Hydrazinopyridine), Bailee G. Duff, Christine Phipps, Craig Grapperhaus Sep 2023

Characterization And Electrolysis Of Zn And Cu 2,6-Diacetylpyridine Bis(2-Hydrazinopyridine), Bailee G. Duff, Christine Phipps, Craig Grapperhaus

The Cardinal Edge

With increasing demands for fuel and concerns over climate change, the search for sustainable energy sources is ever growing. Hydrogen is a potential solution to these issues, as it is clean, recyclable, and efficient. However, hydrogen must be generated, unlike other fuel sources that are naturally ready for use. The most sustainable method for hydrogen production involves water electrolysis, as no pollution is generated. The water splitting process contains a cathodic hydrogen evolution reaction (HER) and an anodic oxygen evolution reaction (OER). These reactions require a catalyst to overcome the kinetic barrier present and meet the high voltage requirements for …

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Organizing Pmode Dopplergrams Of Jupiter With Matlab, Brady T. Smith, Deborah Gulledge, Cody Shaw, Gerard Williger Sep 2023

Organizing Pmode Dopplergrams Of Jupiter With Matlab, Brady T. Smith, Deborah Gulledge, Cody Shaw, Gerard Williger

The Cardinal Edge

The interiors of the giant planets are poorly known. At the time of writing, such investigations have been limited to measuring gravitational effects from a handful of orbital probes. The most recent attempt to map the interior is via PMODE (the Planetary Multilevel Oscillations and Dynamics Experiment), designed to explore Jupiter’s core by collecting Dopplergrams. Small radial velocity shifts in Jupiter’s upper cloud decks enable us to map its atmospheric dynamics and consequently its interior via Dioseismology (techniques similar to Helioseismology, applied to Jupiter). This campaign produced a vast dataset with more than 50,000 exposures, every 30 seconds, over 24 …

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A Citizen Science Experiment: How Well Do Park Visitors Identify Wetland Health?, Madison Cicha, Kassidy Haynes, Andrew Mehring, Mark Tierney, Andrea Gaughan Phd Sep 2023

A Citizen Science Experiment: How Well Do Park Visitors Identify Wetland Health?, Madison Cicha, Kassidy Haynes, Andrew Mehring, Mark Tierney, Andrea Gaughan Phd

The Cardinal Edge

Citizen science refers to a discipline of scientific projects that utilize public participation and collaboration to complete or supplement a collected data set. Our study as a whole aims to assess the greenhouse gas (GHG) source-sink status of small, constructed wetlands in Kentucky through field and remotely sensed data. Additional facets of the project include evaluating the influence of the primary producer community on GHG uptake and emissions, and our ability to identify healthy small wetlands from science and community-based perspectives. Specifically, the citizen science aspect intends to assess both (1) gaps between knowledge of the general public regarding wetland …

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All-Cause And Opioid-Related Mortality Compared Between Traumatic Spinal Cord Injury And The Us General Population, Jaden Whitehead, Beatrice Ugiliweneza Sep 2023

All-Cause And Opioid-Related Mortality Compared Between Traumatic Spinal Cord Injury And The Us General Population, Jaden Whitehead, Beatrice Ugiliweneza

The Cardinal Edge

Individuals with spinal cord injury (SCI) are susceptible to the misuse of opioids due to the introduction of these substances for pain management. There are very few studies examining the relationship between unintentional deaths caused by opioid usage following spinal cord injury. The objective of this study was to evaluate the trend of opioid-related mortality of individuals with spinal cord injury (SCI) over the years and compare these findings to the mortality rates due to opioid misuse in the general population. In this study, we used data provided by the National Spinal Cord Injury Model Systems (NSCIMS) for SCI 1999-2016 …

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The Fierce Green Fire: Vol. 14 Issue 3, Wofford College Environmental Studies Program Sep 2023

The Fierce Green Fire: Vol. 14 Issue 3, Wofford College Environmental Studies Program

The Fierce Green Fire

No abstract provided.

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Tunneling Time And Faraday/Kerr Effects In Pt-Symmetric Systems, Peng Guo, Vladimir Gasparian, Antonio Antonio Perez-Garrido, Ester Jodar Ferrandez Sep 2023

Tunneling Time And Faraday/Kerr Effects In Pt-Symmetric Systems, Peng Guo, Vladimir Gasparian, Antonio Antonio Perez-Garrido, Ester Jodar Ferrandez

Research & Publications

We review the generalization of tunneling time and anomalous behaviour of Fara- day and Kerr rotation angles in parity and time (PT )-symmetric systems. Similarities of two phenomena are discussed, both exhibit a phase transition-like anomalous behaviour in a certain range of model parameters. Anomalous behaviour of tunneling time and Faraday/Kerr angles in PT -symmetric systems is caused by the motion of poles of scattering amplitudes in the en- ergy/frequency complex plane.

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A First Look Into Software Security Practices In Bangladesh, Ankit Shrestha, Tanusree Sharma, Pratyasha Saha, Syed Ishtiaque Ahmed, Mahdi Nasrullah Al-Ameen Sep 2023

A First Look Into Software Security Practices In Bangladesh, Ankit Shrestha, Tanusree Sharma, Pratyasha Saha, Syed Ishtiaque Ahmed, Mahdi Nasrullah Al-Ameen

Computer Science Student Research

Software security practices are critical in minimizing vulnerabilities and protecting unauthorized access to the code and the system. However, software security practices outside Western countries need to be better understood. This need for understanding security practices is further necessitated by the increased outsourcing of software development that can result in vulnerabilities on a global scale. This article addresses this gap, focusing on Bangladesh, a country that represents a booming software industry in the Global South. In this study, we conducted semi-structured interviews with 15 developers to understand their security perceptions and identify the factors influencing software security practices in Bangladesh. …

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Modified Newtonian Dynamics As An Alternative To The Planet Nine Hypothesis, Harsh Mathur Sep 2023

Modified Newtonian Dynamics As An Alternative To The Planet Nine Hypothesis, Harsh Mathur

Faculty Scholarship

A new class of Kuiper Belt objects (KBOs) that lie beyond Neptune with semimajor axes greater than 250 astronomical units show orbital anomalies that have been interpreted as evidence for an undiscovered ninth planet. We show that a modified gravity theory known as modified Newtonian dynamics (MOND) provides an alternative explanation for the anomalies using the well-established secular approximation. We predict that the major axes of the orbits will be aligned with the direction toward the Galactic center and that the orbits cluster in phase space, in agreement with observations of KBOs from the new class. Thus, MOND, which can …

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Final 2021 Unreclaimed Sites Sampling Ur-32 Site Evaluation Summary Report, Pioneer Technical Services, Inc. Sep 2023

Final 2021 Unreclaimed Sites Sampling Ur-32 Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

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Superoscillations And Fock Spaces, Daniel Alpay, Fabrizio Colombo, Kamal Diki, Irene Sabadini, Daniele C. Struppa Sep 2023

Superoscillations And Fock Spaces, Daniel Alpay, Fabrizio Colombo, Kamal Diki, Irene Sabadini, Daniele C. Struppa

Mathematics, Physics, and Computer Science Faculty Articles and Research

In this paper we use techniques in Fock spaces theory and compute how the Segal-Bargmann transform acts on special wave functions obtained by multiplying superoscillating sequences with normalized Hermite functions. It turns out that these special wave functions can be constructed also by computing the approximating sequence of the normalized Hermite functions. First, we start by treating the case when a superoscillating sequence is multiplied by the Gaussian function. Then, we extend these calculations to the case of normalized Hermite functions leading to interesting relations with Weyl operators. In particular, we show that the Segal-Bargmann transform maps superoscillating sequences onto …

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Effects Of Weight Initialization Methods On Ffn's, Ida K. Karem Sep 2023

Effects Of Weight Initialization Methods On Ffn's, Ida K. Karem

The Cardinal Edge

Weight initialization is the method of determining starting values of weights in a neural network. The way this method is done can have massive effects on the network[2, 3, 6, 9] and can halt training if not handled properly. On the other hand, if initialization is chosen tactfully it can improve training and accuracy greatly. The initialization method usually called Normalized Xavier will be referred to as Nox in this paper to avoid confusion with the Xavier initialization method. This study analyzes five methods of weight initialization(Nox, He, Xavier, Plutonian, and Self-Root), two of them …

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Exploring Retrieval Difficulties And Self-Confidence In An Assessment Of General Chemistry Students, Karen Julian, Morgan Balabanoff Sep 2023

Exploring Retrieval Difficulties And Self-Confidence In An Assessment Of General Chemistry Students, Karen Julian, Morgan Balabanoff

The Cardinal Edge

Developing self-assessment skills is an important aspect of learning. Framed by assessment developed for the year-long sequence of general chemistry, students were asked to rate their ability to answer conceptual questions. Using cognitive interviews, this study revealed that people rely on a range of characteristics other than content knowledge to assess their confidence, including doubt, retrieval difficulty, and test-taking methods. These findings imply that more explicit instruction may be required to encourage correct self-assessment. Students can develop their metacognitive skills and calibrate their perceived ability by completing examinations meant to emphasize content knowledge gaps.

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Sentiment Analysis Of Public Perception Towards Elon Musk On Reddit (2008-2022), Daniel Maya Bonilla, Samuel Iradukunda, Pamela Thomas Sep 2023

Sentiment Analysis Of Public Perception Towards Elon Musk On Reddit (2008-2022), Daniel Maya Bonilla, Samuel Iradukunda, Pamela Thomas

The Cardinal Edge

As Elon Musk’s influence in technology and business continues to expand, it becomes crucial to comprehend public sentiment surrounding him in order to gauge the impact of his actions and statements. In this study, we conducted a comprehensive analysis of comments from various subreddits discussing Elon Musk over a 14-year period, from 2008 to 2022. Utilizing advanced sentiment analysis models and natural language processing techniques, we examined patterns and shifts in public sentiment towards Musk, identifying correlations with key events in his life and career. Our findings reveal that public sentiment is shaped by a multitude of factors, including his …

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Eggshell-Alginate Composites (Eacs) As Eco-Friendly Adsorbents For Rhodamine B Uptake From Aqueous Solutions, Rusnadi Rusnadi, Mar’Atus Sholihah, Nurrahmi Handayani, Muhammad Ali Zulfikar Sep 2023

Eggshell-Alginate Composites (Eacs) As Eco-Friendly Adsorbents For Rhodamine B Uptake From Aqueous Solutions, Rusnadi Rusnadi, Mar’Atus Sholihah, Nurrahmi Handayani, Muhammad Ali Zulfikar

Karbala International Journal of Modern Science

The contamination of wastewater by Rhodamine B (RhB) poses a significant environmental concern due to its negative impacts on aesthetics, ecosystems, and human well-being. This study successfully synthesized eco-friendly egg-shell-alginate composites (EACs) as adsorbents by combining alginate solution, eggshell powder, and a 2% CaCl2 solu-tion. Characterization techniques including FTIR, SEM, TGA, and SAA were employed to analyze the EACs. FTIR analysis revealed characteristic absorption peaks corresponding to -OH groups, C=O groups, C-O groups, and the pres-ence of CO32-. The structural analysis confirmed the physical mixture of functional groups from eggshells and alginate, resulting in a homogeneous EACs mixture. TGA analysis …

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Synthesizing Of Alginate Coated-Silver Nanoparticles Core-Shell For Detecting Of S-Naproxen Enantiomer In Pharmaceutical Formulation, Abdolrasol Barazandeh, Ghasem Najafpour-Darz, Afshar Alihossein, Sohrab Kazemi Sep 2023

Synthesizing Of Alginate Coated-Silver Nanoparticles Core-Shell For Detecting Of S-Naproxen Enantiomer In Pharmaceutical Formulation, Abdolrasol Barazandeh, Ghasem Najafpour-Darz, Afshar Alihossein, Sohrab Kazemi

Karbala International Journal of Modern Science

Core-shell nanoparticles were used in a unique direct UV-Vis spectrophotometric technique to detect the S-naproxen enantiomer. Silver nanoparticles (Ag NPs) covered with sodium alginate (Alg) shell, a naturally occurring biopolymer, made the core of the nanostructure. To name a few, TEM, FESEM, UV-Visible, DLS, ZP, AFM, XRD, EDX and FT-IR are among the analytical methods used to analyze the creation of the core-shell structure. Based on obtained results, spherical Ag@ Alg NPs with an average size of 27.4 nm (DTEM), hydrolytic size of 46 nm (DDLS) and surface charge of -60.9 mV were successfully synthesized. The effect of various reaction …

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Improving The Structural And Physical Yield Of Aluminum By Repeated Additions Of Iron Carbide, Fayrooz K. Albasri Sep 2023

Improving The Structural And Physical Yield Of Aluminum By Repeated Additions Of Iron Carbide, Fayrooz K. Albasri

Al-Bahir

Aluminum suffers from low hardness and some ductility when thermal sintering which requires reinforcement with carbide or ceramic materials as Iron FeC with volumetric properties (2,4,6,8,10 )%. For purpose of the pressing process after mixing the two powder together, a scanning electron microscope examination performed for the prepared samples and found that there is a surface and structural consistency between aluminum and iron carbide and the best homogeneity is at10 % of carbide. Also some physical tests conducted for prepared samples and the results of the real density showed that the addition of iron carbide increases the density gradually and …

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Overview Of The Clef-2023 Checkthat! Lab Task 4 On Factuality Of Reporting Of News Media, Preslav Nakov, Firoj Alam, Giovanni Da San Martino, Maram Hasanain, Dilshod Azizov, Rabindra Nath Nandi, Panayotov Panayot Sep 2023

Overview Of The Clef-2023 Checkthat! Lab Task 4 On Factuality Of Reporting Of News Media, Preslav Nakov, Firoj Alam, Giovanni Da San Martino, Maram Hasanain, Dilshod Azizov, Rabindra Nath Nandi, Panayotov Panayot

Natural Language Processing Faculty Publications

We present an overview of the CLEF-2023 CheckThat! lab Task 4, which focused on predicting the factuality of reporting of entire news outlets. This is a different level of granularity compared to previous efforts, which focused on fact-checking, where the target is a claim, or fake news detection, where the target is an article. We briefly summarize the participating systems and discuss the dataset, the task, and the evaluation setup. The task attracted a large number of registrations, and eventually five teams made submissions. All participants improved over the baseline by a margin using both deep learning and traditional machine …

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Time-Resolved Cryo-Em (Tr-Em) Analysis Of Substrate Polyubiquitination By The Ring E3 Anaphase-Promoting Complex/Cyclosome (Apc/C), Tatyana Bodrug, Kaeli A. Welsh, Derek L. Bolhuis, Ethan Paulаkonis, Raquel C. Martinez-Chacin, Bei Liu, Nicholas Pinkin, Thomas Bonacci, Liying Cui, Pengning Xu, Olivia Roscow, Sascha Josef Amann, Irina Grishkovskaya, Michael J. Emanuele, Joseph S. Harrison, Joshua P. Steimel, Klaus M. Hahn, Wei Zhang, Ellen D. Zhong, David Haselbach, Nicholas G. Brown Sep 2023

Time-Resolved Cryo-Em (Tr-Em) Analysis Of Substrate Polyubiquitination By The Ring E3 Anaphase-Promoting Complex/Cyclosome (Apc/C), Tatyana Bodrug, Kaeli A. Welsh, Derek L. Bolhuis, Ethan Paulаkonis, Raquel C. Martinez-Chacin, Bei Liu, Nicholas Pinkin, Thomas Bonacci, Liying Cui, Pengning Xu, Olivia Roscow, Sascha Josef Amann, Irina Grishkovskaya, Michael J. Emanuele, Joseph S. Harrison, Joshua P. Steimel, Klaus M. Hahn, Wei Zhang, Ellen D. Zhong, David Haselbach, Nicholas G. Brown

Pacific Faculty Work

Substrate polyubiquitination drives a myriad of cellular processes, including the cell cycle, apoptosis and immune responses. Polyubiquitination is highly dynamic, and obtaining mechanistic insight has thus far required artificially trapped structures to stabilize specific steps along the enzymatic process. So far, how any ubiquitin ligase builds a proteasomal degradation signal, which is canonically regarded as four or more ubiquitins, remains unclear. Here we present time-resolved cryogenic electron microscopy studies of the 1.2 MDa E3 ubiquitin ligase, known as the anaphase-promoting complex/cyclosome (APC/C), and its E2 co-enzymes (UBE2C/UBCH10 and UBE2S) during substrate polyubiquitination. Using cryoDRGN (Deep Reconstructing Generative Networks), a neural …

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2023 September 21 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University Sep 2023

2023 September 21 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

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