Physical Sciences and Mathematics Commons^™

Predicting Endothelium-Dependent Diastolic Function (Fmd)And Its Correlation With The Degree Of Coronary Artery Disease (Cad) And Plaque Vulnerability For Cardiovascular Events, Guoqing Gu

Faculty, Staff and Student Publications

OBJECTIVE: This study aims to investigate the correlation between vascular endothelium-dependent diastolic function (FMD) and the degree of coronary artery disease (CAD), plaque vulnerability, and its predictive value for cardiovascular events.

METHODS: Initially, patients (n=100) who were admitted from January 2020 to January 2021 and intended to undergo percutaneous coronary intervention (PCI) were selected. Further, FMD in all patients was determined before the procedure and divided into a high-FMD group (≥4.2%) and a low-FMD group (

RESULTS: No significant differences were observed concerning general information, number of coronary arteries-associated branches, lesion type, involvement of the left main stem (LM), the …

Statins Are Rarely Prescribed For Incidentally Discovered Covert Cerebrovascular Disease: A Retrospective Cohort In A Large Electronic Health Record (Ehr) Identified Using Natural Language Processing, Sunyang Fu, Chengyi X Zheng, Hongfang Liu, Wansu Chen, David M Kent

Faculty, Staff and Student Publications

Introduction: While incidentally discovered covert cerebrovascular diseases (id-CCD) are associated with future stroke, it is not known if patients with id-CCD are prescribed statins.

Methods: Patients age ≥50 with id-CCD on neuroimaging from 2009 to 2019 with no prior ischaemic stroke, transient ischaemic attack or dementia were identified using natural language processing in a large real-world cohort. Robust Poisson multivariable regression was used to assess statin prescription among patients without prior statins.

Results: Among 2 41 050 patients, 74 975 patients (31.1%; 4.7% with covert brain infarcts (CBI); 29.0% with white matter disease (WMD)) had id-CCD. 53.5% (95% CI 53.2 …

The Enact Network Is Acting On Housing Instability And The Unhoused Using The Open Health Natural Language Processing Toolkit, Darren Henderson, Jordan Hilsman, David Oniani, Yanshan Wang

Faculty, Staff and Student Publications

Housing is an environmental social determinant of health that is linked to mortality and clinical outcomes. We developed a lexicon of housing-related concepts and rule-based natural language processing methods for identifying these housing-related concepts within clinical text. We piloted our methods on several test cohorts: a synthetic cohort generated by ChatGPT for initial infrastructure testing, a cohort with substance use disorders (SUD), and a cohort diagnosed with problems related to housing and economic circumstances (HEC). Our methods successfully identified housing concepts in our ChatGPT notes (recall = 1.0, precision = 1.0), our SUD population (recall = 0.9798, precision = 0.9898), …

Preparing Healthcare Education For An Ai-Augmented Future

Faculty, Staff and Student Publications

Artificial intelligence (AI) fundamentally transforms healthcare education as a knowledge enterprise, creating a distributed cognitive system composed of the human brain, which remains relatively unchanged, and AI-based knowledge and cognitive functions, which have accelerated exponentially in scale and power. Education must focus on developing skills to collaborate with AI and on achieving outcomes like problems solved and discoveries made. Curriculum and education policies also need to adapt to this transformation.

Descriptor:Benchmarking Secure Neural Network Evaluation Methods For Protein Sequence Classification (Idash24)

Faculty, Staff and Student Publications

To uniformly test and benchmark the secure evaluation of transformer-based models, we designed the iDASH24 homomorphic encryption track dataset. The dataset comprises a protein family classification model with a transformer architecture and an example dataset that is used to build and test the secure evaluation strategies. This dataset was used in the challenge period of iDASH24 Genomic Privacy Competition, where the teams designed secure evaluation of the classification model using a homomorphic encryption scheme. Combined with the benchmarking results and companion methods, iDASH24 dataset is a unique resource that can be used to benchmark secure evaluation of neural network models.

Applications Of Physics-Informed Graph Neural Networks In Wind Farm Layout Optimization, Emma R. Martin

Theses and Dissertations

Rapid advancements in data-driven deep learning models have led to their increased usage in recent years. Highly-effective models for conducting complex decision-making tasks have been developed. Given their success, data-driven deep learning models are being developed and improved in a variety of areas, one of which is renewable energy. In this thesis, we discuss the development of data-driven, deep learning models for optimizing wind farm layouts for maximum power output. We include a background for wind energy, the physics of fluid flow and power production, and two types of neural networks: graph neural networks and physics-informed neural networks. Additionally, we …

A Transformer-Based Deep Learning Approach For Fairly Predicting Post-Liver Transplant Risk Factors

Faculty, Staff and Student Publications

Liver transplantation is a life-saving procedure for patients with end-stage liver disease. There are two main challenges in liver transplant: finding the best matching patient for a donor and ensuring transplant equity among different subpopulations. The current MELD scoring system evaluates a patient's mortality risk if not receiving an organ within 90 days. However, the donor-patient matching should also consider post-transplant risk factors, such as cardiovascular disease, chronic rejection, etc., which are all common complications after transplant. Accurate prediction of these risk scores remains a significant challenge. In this study, we used predictive models to solve the above challenges. Specifically, …

Rado Numbers For Two Systems Of Linear Equations, Anthony Glackin

Electronic Theses and Dissertations

For any positive integer n and any equation E of either the form x1+x2+· · ·+xn = x0 or x1 + x2 + n = x0, the two-color Rado number R2(E) is the least integer such that any 2-coloring of the natural numbers 1 through R2(E) will contain a monochromatic solution to E. Let Ek be a system of k equations of the aforementioned form, where Ei represents the ith equation in Ek and the set I = {1, 2, . . . , k} is the set of indices of these equations. This thesis shows that the two-color Rado …

Modeling Coupled Driving Behavior During Lane Change: A Multi-Agent Transformer Reinforcement Learning Approach, Hongyu Guo, Mehdi Keyvan-Ekbatani, Kun Xie

Civil & Environmental Engineering Faculty Publications

In a lane change (LC) scenario, the lane change vehicle interacts with surrounding vehicles. The interactions not only affect their driving behaviors but also influence the traffic flow. This study aims to model the coupled behavior of the lane changer and the follower in the target lane during LC. Large-scale real-world connected vehicle (CV) data from the Safety Pilot Model Deployment (SPMD) program are used to extract LCs and study vehicle interactions. A multi-agent Transformer-based deep deterministic policy gradient (MA-TDDPG) method is proposed to model the coupled behaviors during LC. The multi-agent framework can handle the multiple agents’ behaviors with …

Investigating The Viability Of Low Frequency Mhvsr Estimates Using Deep Shear Wave Velocity Profile, T. Mai, C. C. Nweke, P. Wang, F. J. Ornelas

Civil & Environmental Engineering Faculty Publications

Site response describes the alterations of seismic energy due to its interaction with subsurface geological interfaces and structures, which is usually estimated by one dimensional (1D) ground response analysis (GRA). However, 1D GRA requires subsurface information (e.g., shear wave velocity profile), which makes it not widely applicable, particularly for the sites where subsurface information is unavailable. Alternatively, the microtremor horizontal-to-vertical spectral ratio (mHVSR) from three-component recordings of ambient noise on the ground surface is easily measured and is believed to have the potential for site response prediction (the peaks in mHVSR are strongly associated with the site resonant frequencies). However,the …

Comparative Analysis Of Machine Learning Models For Predicting Healthcare Traffic: Insights For Optimized Emergency Response, Shadman Mahmood Khan Pathan, Sakan Binte Imran, M. M. Shabab Iqbal, Muhammad Enayetur Rahman, Md. Nurul Absar Siddiky, Muhammad Rezaur Rahman, Md Rafid Hasan, Nondon Lal Dey, Md Sobuj Hossain

Electrical & Computer Engineering Faculty Publications

Efficient management of healthcare traffic is crucial for ensuring timely access to medical services, particularly in emergency situations where delays can have severe consequences. This study presents a comparative analysis of three widely used machine learning models—Linear Regression, Decision Trees, and Random Forests—aimed at predicting healthcare-related traffic volumes. A large dataset from a metropolitan traffic system was used to train and evaluate the models based on key performance indicators, including Mean Squared Error (MSE), R² Score, and computational efficiency. The results reveal that the Random Forest model offers the best performance, achieving higher predictive accuracy and faster execution times compared …

Teaching Analytics Online: A Self-Study Of Professional Practice, Andrew J. Collins, Brandon Butler, James F. Leathrum Jr., Christopher J. Lynch

Engineering Management & Systems Engineering Faculty Publications

As the COVID-19 pandemic caused severe disruption to education enterprises throughout the world, the main response by educational institutions was to move to online learning environments. The purpose of this study was to understand better how instructors could improve online learning for a professional-level week-long short course in a highly technical area (data analytics), which had, pre-COVID, been a hands-on computer, laboratory-based learning experience. The authors used self-study of professional practice to elicit and understand the major issues and concerns of the transition to an online learning environment. Under the guidance of a colleague in teacher education, three course instructors …

Methods That Support The Validation Of Agent-Based Models: An Overview And Discussion, Andrew Collins, Matthew Koehler, Christopher Lynch

Engineering Management & Systems Engineering Faculty Publications

Validation is the process of determining if a model adequately represents the system under study for the model’s intended purpose. Validation is a critical component in building the credibility of a simulation model with its end-users. Effectively conducting validation can be a daunting task for both novice and experienced simulation developers. Further compounding the difficult task of conducting validation is that there is no universally accepted approach for assessing a simulation. These challenges are particularly relevant to the paradigm of Agent-Based Modeling and Simulation (ABMS) because of the complexity found in these models’ mechanisms and in the real-world situations they …

Advancing Household Robotics: Deep Interactive Reinforcement Learning For Efficient Training And Enhanced Performance, Arpita Soni, Sujatha Alla, Suresh Dodda, Hemanth Volikatla

Engineering Management & Systems Engineering Faculty Publications

The market for domestic robots—made to perform household chore, is growing as these robots relieve people of everyday responsibilities. Domestic robots are generally welcomed for their role in easing human labour, in contrast to industrial robots, which are frequently criticised for displacing human workers. But before these robots can carry out domestic chores, they need to become proficient in a number of minor activities, such as recognizing their surroundings, making decisions, and picking up on human behaviours. Reinforcement learning, or RL, has emerged as a key robotics technology that enables robots to interact with their environment and learn how to …

A Generative Approach For Document Enhancement With Small Unpaired Data, Mohammad Shahab Uddin, Wael Khallouli, Andres Sousa-Poza, Samuel Kovacic, Jiang Li

Engineering Management & Systems Engineering Faculty Publications

Shipbuilding drawings, crafted manually before the digital era, are vital for historical reference and technical insight. However, their digital versions, stored as scanned PDFs, often contain significant noise, making them unsuitable for use in modern CAD software like AutoCAD. Traditional denoising techniques struggle with the diverse and intense noise found in these documents, which also does not adhere to standard noise models. In this paper, we propose an innovative generative approach tailored for document enhancement, particularly focusing on shipbuilding drawings. For a small, unpaired dataset of clean and noisy shipbuilding drawing documents, we first learn to generate the noise in …

Integrative Machine Learning Approaches For Enhanced Classification Of Genomic Sequences: A Next-Generation Sequencing Perspective, Sujatha Alla, Nagesh Bheesetty, Sai Gireesh Komaragiri, Prasanthi Chidipudi, Joshit Mohanty, Sathish Kumar Chintala, Jubin Thomas, Jayapal Vummadi, Hemanth Volikatla, Navin Kamuni

Engineering Management & Systems Engineering Faculty Publications

The advent of Next-Generation Sequencing (NGS) techniques has revolutionized genomic research by enabling the rapid sequencing of DNA and RNA. This data can be used for various applications, including genome sequencing, transcriptome profiling, metagenomics, and epigenetics studies. For this study, DNA classifier dataset was extracted from UCI repository of machine learning databases. This vast amount of genomic data necessitates the development of sophisticated machine learning (ML) models for effective classification and analysis. This study presents a comprehensive comparison of various ML models, including Support Vector Machines (SVM), Random Forests (RF), and Neural Networks (NNs), approaches, in classifying genomic data. We …

Reinforcement Learning For Optimal Kicking Actions In Humanoid Robotics: Advancing Robotic Autonomy And Versatility, Suresh Dodda, Sathish Kumar Chintala, Sukender Reddy Mallreddy, Sharath Chandra Macha, Yashwanth Vasa, Sapan Bharadwaj Bonala, Navin Kamuni, Sujatha Alla

Engineering Management & Systems Engineering Faculty Publications

Acquiring the necessary skills to perform a work effectively and efficiently requires a significant investment of time and computing power. Previous applications of Reinforcement Learning (RL) for action optimization in humanoid robotics have shown how promising this technology is for moving robotics towards true autonomy and versatility. Therefore, this study offers the first use of RL to create an entirely optimal kicking action for the Alderbaran Nao robot. Kicking motions that were steady, precise, quick, and able to kick farther than any existing RoboCup squad were generated by optimizing for a multi-objective reward function. We demonstrate that the ideal kicking …

Data Driven Trade-Off Analysis For Cybersecurity, Goskel Kucukkaya, Murat Ozer, Murat Balci, Emrah Ugurlu

Engineering Management & Systems Engineering Faculty Publications

Trade-off analysis, a specialization of systems engineering, addresses design criteria like security, cost, performance, and compliance. Monte Carlo simulations are commonly employed to generate impact scenarios for trade-off analysis combined with solution alternatives that accommodate industry-specific considerations and uncertainties. In the cyber domain, this paper proposes a methodology for data-driven trade-off analysis in cybersecurity, leveraging industry reports as primary data sources using confidentiality, integrity, and availability as trade-off analysis objectives. Distribution functions are derived to manage and model uncertainties for various industries. The approach given in this study aims to facilitate informed choices and to enhance cybersecurity decision making and …

Conflict Profiles And Team Outcomes In Cross-Disciplinary Teams: An Integrated Latent Profile Analysis And Natural Language Processing Approach, Francisco Cima, Pilar Pazos

Engineering Management & Systems Engineering Faculty Publications

Team conflict is a naturally emerging phenomenon resulting from individuals' interactions during project execution. Cross-disciplinary teams can experience higher levels of conflict than single-discipline teams because of the increased diversity of knowledge and perspectives. Research has shown that team conflict can emerge from different types of disagreements (cognitive and interpersonal), which have different implications for team functioning. Past empirical research has focused on the impact of both conflict types independent from each other while overlooking their combined effects. This work examines the conflict profiles resulting from the combined levels of interpersonal and cognitive disagreements and their association with team outcomes. …

Asem 4.0/5.0 - Evolving The Engineering Management Profession Through Industry 4.0/5.0 Collaborative Networks, T. Steven Cotter, Faisal Mahmud, Ziniya Zahedi

Engineering Management & Systems Engineering Faculty Publications

The American Society for Engineering Management was created and matured under Industry 3.0 automation. The emergence of Industry 4.0 and 5.0 are forcing all organizational sectors to rethink their long-term strategy with respect to emerging horizontal/vertical cyber-physical systems integration. This leaves open the question of the directions in which ASEM should evolve into the 21st century. This paper reports an initial mapping of Industry 4.0 and 5.0 technologies and initiatives as goal-oriented, long-term strategic collaborative networks. The research method began with the Boston Consulting Group nine technologies of Industry 4.0 (2015) and the Industry 5.0 technologies within its human-centric, sustainability, …

Integrating Generative Artificial Intelligence With Systems Architecting Diagram Creation: Advancement, Challenges, Opportunities And Future Perspectives, Cansu Yalim, Holly H. Handley

Engineering Management & Systems Engineering Faculty Publications

Generative AI (GenAI) serves as a powerful tool that can create a wide range of content, including but not limited to text, speech, images, code, videos, and 3D models. ChatGPT stands out as a particularly appealing Generative Pretrained Transformer (GPT) model that offers supplementary capabilities through GPTs and plugins. These extensions enable users to engage with the chatbot and improve its functionality, surpassing mere content generation. Our study delves into the potential of ChatGPT, specifically GPT-4, to expedite the creation of diagrams to support the system architecting process. To this end, we explored the use of ChatGPT's Diagrams Show Me …

Recommendations To Internal Auditors Regarding The Auditing And Attestation Of Mathematical Programming Models, Jose Rincón, Greg Akai, Daryl Ono

Librarian Publications & Presentations

Mathematical programming planning models increase operational efficiency and minimize operating costs, but the underlying mathematics generally is complex. Combinatorial optimization is technically sophisticated which requires a strong quantitative background to successfully implement. Most internal auditors will not have the technical training to critically assess the underlying mathematics of mathematical programming planning models, but the internal auditor can still provide insight and attestation which can increase the efficiency of mathematical programming planning models.

Listening To The Voices Of America, Kathryn J. Edin, Corey D. Fields, David B. Grusky, Jure Leskovec, Marybeth J. Mattingly, Kristen M. Olson, Charles Varner

Department of Sociology: Faculty Publications

We make the case for building a permanent public-use platform for conducting and analyzing immersive interviews on the everyday lives of Americans. The American Voices Project (AVP)—a widely watched experiment with this new platform—provides important early evidence on its promise. The articles in this issue reveal that, although public-use interview datasets obviously cannot meet all research needs, they do provide new opportunities to study small or hidden populations, new or emerging social problems, reactions to ongoing social crises, submerged values and attitudes, and many other aspects of American life. We conclude that a permanent AVP platform would help build an …

Plasmid-Borne Biosynthetic Gene Clusters Within A Permanently Stratified Marine Water Column, Paraskevi Mara, David Geller-Mcgrath, Elizabeth A. Suter, Gordon T. Taylor, Maria G. Pachiadaki, Virginia P. Edgcomb

BCES: Faculty Publications

Plasmids are mobile genetic elements known to carry secondary metabolic genes that affect the fitness and survival of microbes in the environment. Well-studied cases of plasmidencoded secondary metabolic genes in marine habitats include toxin/antitoxin and antibiotic biosynthesis/resistance genes. Here, we examine metagenome-assembled genomes (MAGs) from the permanently-stratified water column of the Cariaco Basin for integrated plasmids that encode biosynthetic gene clusters of secondary metabolites (smBGCs). We identify 16 plasmid-borne smBGCs in MAGs associated primarily with Planctomycetota and Pseudomonadota that encode terpenesynthesizing genes, and genes for production of ribosomal and non-ribosomal peptides. These identified genes encode for secondary metabolites that are …

In Vivo Measurement Of Nadh Fluorescence Lifetime In Skeletal Muscle Via Fiber-Coupled Time-Correlated Single Photon Counting, Kathryn M. Priest, Jacob V. Schluns, Nathania Nischal, Colton L. Gattis, Jeffery C. Wolchok, Timothy J. Muldoon

Biomedical Engineering Faculty Publications and Presentations

Nicotinamide adenine dinucleotide (NADH) is a cofactor that serves to shuttle electrons during metabolic processes such as glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation (OXPHOS). NADH is autofluorescent, and its fluorescence lifetime can be used to infer metabolic dynamics in living cells. Fiber-coupled time-correlated single photon counting (TCSPC) equipped with an implantable needle probe can be used to measure NADH lifetime in vivo, enabling investigation of changing metabolic demand during muscle contraction or tissue regeneration. This study illustrates a proof of concept for point-based, minimally-invasive NADH fluorescence lifetime measurement in vivo. Volumetric muscle loss (VML) injuries were …

Synthesis And Characterisation Of Molecularly Imprinted Polymers On Functionalised Silica Gel Designed For The Selective Extraction And Detection Of Nitroaromatic Compounds Coupled With Colorimetric Methods, Raymond Tang

Masters

HPLC and LC-MS are analytical instruments used to detect the trace explosives, however, the instrumental methods are expensive and require specially trained operators to prepare the samples and interpret the results, and these methods are not suitable for use in conflict zones. The overall aim is to deliver a method for the selective, sensitive and rapid detection of trace explosives in the field.

Disaggregating Longer-Term Trends From Seasonal Variations In Measured Pv System Performance, Chibuisi Chinasaokwu Okorieimoh, Brian Norton, Michael Conlon

Articles

Photovoltaic (PV) systems are widely adopted for renewable energy generation, but their performance is influenced by complex interactions between longer-term trends and seasonal variations. This study aims to remove these factors and provide valuable insights for optimising PV system operation. We employ comprehensive datasets of measured PV system performance over five years, focusing on identifying the distinct contributions of longer-term trends and seasonal effects. To achieve this, we develop a novel analytical framework that combines time series and statistical analytical techniques. By applying this framework to the extensive performance data, we successfully break down the overall PV system output into …

A Spiral Workbook For Discrete Mathematics 2nd Edition, Harris Kwong

Milne Open Textbooks

This updated text covers the standard topics in a sophomore-level course in discrete mathematics: logic, sets, proof techniques, basic number theory, functions, relations, and elementary combinatorics, with an emphasis on motivation. It explains and clarifies the unwritten conventions in mathematics, and guides the students through a detailed discussion on how a proof is revised from its draft to a final polished form. Hands-on exercises help students understand a concept soon after learning it. The text adopts a spiral approach: many topics are revisited multiple times, sometimes from a different perspective or at a higher level of complexity. The goal is …

The Importance Of Ice Microphysics In Storm Electrification, Yichen Cai

Electronic Theses & Dissertations (2024 - present)

Evanescent but powerful, lightning is the vast scale release of storm energy from accumulation of minuscule cloud particle interactions. Although lightning occurrence seems random, thunderstorms “electrify” themselves in methodical ways and show structured patterns. This study explores the role of ice microphysics in thunderstorm charging and discharge through numerical simulation.

A squall line has been simulated ideally and realistically with generally consistent conclusions. Drastically different amount of lightning was produced when using three different microphysical models: Depending on the choice of charging scheme, the National Severe Storm Laboratory (NSSL) two-moment model appropriately captures or overestimate the amount observed by the …

Descriptive Statistical Analysis Of Experimental Data For Wettability Alteration With Smart Water Flooding In Carbonate Reservoirs, Muhammad Ali Buriro, Mingzhen Wei, Baojun Bai, Ya Yao

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Smart water flooding is a promising eco-friendly method for enhancing oil recovery in carbonate reservoirs. the optimal salinity and ionic composition of the injected water play a critical role in the success of this method. This study advances the field by employing machine learning and data analytics to streamline the determination of these critical parameters, which are traditionally reliant on time-intensive laboratory work. the primary objectives are to utilize data analytics to examine how smart water flooding influences wettability modification, identify key parameter ranges that notably alter the contact angle, and formulate guidelines and screening criteria for successful lab design. …