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Articles 32581 - 32610 of 294391
Full-Text Articles in Physical Sciences and Mathematics
Light That Appears To Come From A Source That Does Not Exist, Itamar Stern, Yakov Bloch, Einav Grynszpan, Merav Kahn, Yakir Aharonov, Justin Dressel, Eliahu Cohen, John C. Howell
Light That Appears To Come From A Source That Does Not Exist, Itamar Stern, Yakov Bloch, Einav Grynszpan, Merav Kahn, Yakir Aharonov, Justin Dressel, Eliahu Cohen, John C. Howell
Mathematics, Physics, and Computer Science Faculty Articles and Research
Superoscillatory, band-limited functions oscillate faster than their fastest Fourier component. Superoscillations have been intensively explored recently as they give rise to many out-of-the-spectrum phenomena entailing both fundamental and applied significance. We experimentally demonstrate a form of superoscillations which is manifested by light apparently coming from a source located far away from the actual one. These superoscillations are sensed through sharp transverse shifts in the local wave vector at the minima of a pinhole diffraction pattern. We call this phenomenon “optical ventriloquism.”
Prediction Of Hydrogel Degradation Time Based On Central Composite Design, Manlai Zhang, Xiaohui Li
Prediction Of Hydrogel Degradation Time Based On Central Composite Design, Manlai Zhang, Xiaohui Li
Faculty, Staff and Student Publications
In this study, a self-degrading hydrogel was formed by free-radical-initiated copolymerization, which can be used for oil and gas well strip pressure operations. Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (1H NMR), scanning electron microscopy (SEM), and thermogravimetry-mass spectrometry (TGA-MS) were used to study the reaction mechanism as well as the microstructure of the gels. Then, the effects of the four factors and their interactions on gel degradation time were determined by central composite design (CCD). Then, the effects of copolymer concentration, cross-linker, initiator, and reaction temperature and their interactions on gel degradation time were determined by central composite …
Clpfudatabase: A Suite Of R Packages For Energy Conversion Chain Analysis, Matthew Kuperus Heun, Zeke Marshall, Emmanuel Aramendia
Clpfudatabase: A Suite Of R Packages For Energy Conversion Chain Analysis, Matthew Kuperus Heun, Zeke Marshall, Emmanuel Aramendia
University Faculty Publications and Creative Works
Energy flowing through societal energy conversion chains (ECCs) enables economic activity and facilitates human flourishing. To understand economic growth and human well-being, the field of societal energy analysis (Common, 1976) evaluates ECCs from the primary stage (resources extracted from the environment, such as coal, oil, natural gas, wind, and solar), to the final stage (energy purchased by consumers, such as refined petroleum and electricity), to the useful stage (energy desired by the end user, such as heat, motion, and light), and sometimes to energy services (such as thermal comfort, transport, and illumination). Societal exergy analysis (SEA) (Ertesvåg, 2001), an extension …
Physics 100 Level Laboratory Data Collection Tables, Kalani Hettiarachchilage
Physics 100 Level Laboratory Data Collection Tables, Kalani Hettiarachchilage
Open Educational Resources
The physics 100-level laboratory part demonstrates and applies the material learned from related classes. This document shows guidelines for collecting data and analyzing them by using Microsoft Excel. Laboratory components of PHY 114/ PHY 206/SLS 261 (Introduction to Physics and Nature of Physical Processes), PHY116/PHY 121 (Physics I and General Physics I), and PHY 156/PHY 161 (Physics II and General Physics II) at College of Staten Island are in-person mandatory sessions for students and it is required to pass to receive a passing grade for that class. This part is taught by different instructors. Although everyone is supposed to follow …
Training Data Augmentation With Data Distilled By Principal Component Analysis, Nikolay Metodiev Sirakov, Tahsin Shahnewaz, Arie Nakhmmani
Training Data Augmentation With Data Distilled By Principal Component Analysis, Nikolay Metodiev Sirakov, Tahsin Shahnewaz, Arie Nakhmmani
Faculty Publications
This work develops a new method for vector data augmentation. The proposed method applies principal component analysis (PCA), determines the eigenvectors of a set of training vectors for a machine learning (ML) method and uses them to generate the distilled vectors. The training and PCA-distilled vectors have the same dimension. The user chooses the number of vectors to be distilled and augmented to the set of training vectors. A statistical approach determines the lowest number of vectors to be distilled such that when augmented to the original vectors, the extended set trains an ML classifier to achieve a required accuracy. …
Radio Measurements Of The Depth Of Air-Shower Maximum At The Pierre Auger Observatory, A. Abdul Halim, P. Abreu, M. Aglietta, I. Allekotte, K. Almeida Cheminant, A. Almela, B. Fick, D. Nitz, K. Nguyen, A. Puyleart, Et Al.
Radio Measurements Of The Depth Of Air-Shower Maximum At The Pierre Auger Observatory, A. Abdul Halim, P. Abreu, M. Aglietta, I. Allekotte, K. Almeida Cheminant, A. Almela, B. Fick, D. Nitz, K. Nguyen, A. Puyleart, Et Al.
Michigan Tech Publications
The Auger Engineering Radio Array (AERA), part of the Pierre Auger Observatory, is currently the largest array of radio antenna stations deployed for the detection of cosmic rays, spanning an area of 17 km2 with 153 radio stations. It detects the radio emission of extensive air showers produced by cosmic rays in the 30-80 MHz band. Here, we report the AERA measurements of the depth of the shower maximum (Xmax), a probe for mass composition, at cosmic-ray energies between 1017.5 and 1018.8 eV, which show agreement with earlier measurements with the fluorescence technique at the Pierre Auger Observatory. We show …
Demonstrating Agreement Between Radio And Fluorescence Measurements Of The Depth Of Maximum Of Extensive Air Showers At The Pierre Auger Observatory, A. Abdul Halim, P. Abreu, M. Aglietta, I. Allekotte, K. Almeida Cheminant, A. Almela, B. Fick, D. Nitz, K. Nguyen, A. Puyleart, Et Al.
Demonstrating Agreement Between Radio And Fluorescence Measurements Of The Depth Of Maximum Of Extensive Air Showers At The Pierre Auger Observatory, A. Abdul Halim, P. Abreu, M. Aglietta, I. Allekotte, K. Almeida Cheminant, A. Almela, B. Fick, D. Nitz, K. Nguyen, A. Puyleart, Et Al.
Michigan Tech Publications
We show, for the first time, radio measurements of the depth of shower maximum (Xmax) of air showers induced by cosmic rays that are compared to measurements of the established fluorescence method at the same location. Using measurements at the Pierre Auger Observatory we show full compatibility between our radio and the previously published fluorescence dataset, and between a subset of air showers observed simultaneously with both radio and fluorescence techniques, a measurement setup unique to the Pierre Auger Observatory. Furthermore, we show radio Xmax resolution as a function of energy and demonstrate the ability to make competitive high-resolution Xmax …
Finding A Basic Feasible Solution For Neutrosophic Linear Programming Models: Case Studies, Analysis, And Improvements, Maissam Jdid, Florentin Smarandache
Finding A Basic Feasible Solution For Neutrosophic Linear Programming Models: Case Studies, Analysis, And Improvements, Maissam Jdid, Florentin Smarandache
Neutrosophic Systems with Applications
Since the inception of operations research, linear programming has received the attention of researchers in this field due to the many areas of its use. The focus was on the methods used to find the optimal solution for linear models. The direct simplex method, with its three basic stages, begins by writing the linear model in standard form and then finding a basic solution that is improved according to the simplex steps until We get the optimal solution, but we encounter many linear models that do not give us a basic solution after we put it in a standard form, …
Fuzzy Inference Full Implication Method Based On Single Valued Neutrosophic T-Representable T-Norm: Purposes, Strategies, And A Proof-Of-Principle Study, Minxia Luo, Ziyang Sun, Donghui Xu, Lixian Wu
Fuzzy Inference Full Implication Method Based On Single Valued Neutrosophic T-Representable T-Norm: Purposes, Strategies, And A Proof-Of-Principle Study, Minxia Luo, Ziyang Sun, Donghui Xu, Lixian Wu
Neutrosophic Systems with Applications
As a generalization of intuitionistic fuzzy sets, single-valued neutrosophic sets have certain advantages in solving indeterminate and inconsistent information. In this paper, we study the fuzzy inference full implication method based on single-valued neutrosophic t-representable t-norm. Firstly, single-valued neutrosophic fuzzy inference triple I principles for fuzzy modus ponens and fuzzy modus tollens are given. Then, single-valued neutrosophic R-type triple I solutions for FMP and FMT are given. Finally, the robustness of the full implication triple I method based on the left-continuous single-valued neutrosophic t-representable t-norm is investigated. As a special case of the main results, the sensitivity of full implication …
Pairing New Approach Of Tree Soft With Mcdm Techniques: Toward Advisory An Outstanding Web Service Provider Based On Qos Levels, Sara Fawaz Al-Baker, Ibrahim El-Henawy, Mona Mohamed
Pairing New Approach Of Tree Soft With Mcdm Techniques: Toward Advisory An Outstanding Web Service Provider Based On Qos Levels, Sara Fawaz Al-Baker, Ibrahim El-Henawy, Mona Mohamed
Neutrosophic Systems with Applications
Web services (WSs) have become dynamic because of technological advancements and internet usage. Hence, selecting a WS provider among a variety of WS providers that perform the same function is a critical process. However, the crucial point is that various consumers may have varied needs when it comes to the quality attributes of services, such as cost, response time, throughput, security, availability, etc. These aspects of Web services are known as quality of service (QoS), or non-functional characteristics. Hence, this issue is the robust motivator for conducting this study. The objective of this study is to evaluate a set of …
Forecasting Foreign Tourist Arrivals In India: A Strategic Analysis For Sustainable Religious Tourism Growth, Vishwajeet Singh, Dr. Taruna, Tarushree Bari, Subhash Kumar Yadav
Forecasting Foreign Tourist Arrivals In India: A Strategic Analysis For Sustainable Religious Tourism Growth, Vishwajeet Singh, Dr. Taruna, Tarushree Bari, Subhash Kumar Yadav
International Journal of Religious Tourism and Pilgrimage
The exponential growth of the tourism industry in India significantly impacts the nation’s economic landscape. This study presents an analysis of tourism arrival trends from 2000 to 2019 to forecast foreign tourist arrivals, aligning with the broader scope of religious tourism and pilgrimage. Employing the Box-Jenkins methodology, the research aims to project short-term forecasts for inbound tourism. Diverse modelling techniques are explored to capture the nuances of the time series data, including the assessment of stationarity using the Dickey-Fuller Test to discern underlying trends. The study culminates in identifying the A.R.I.M.A (0, 1, 1) model with drift as the most …
Fuzzy Inference Full Implication Method Based On Single Valued Neutrosophic T-Representable T-Norm: Purposes, Strategies, And A Proof-Of-Principle Study, Minxia Luo, Ziyang Sun, Donghui Xu, Lixian Wu
Fuzzy Inference Full Implication Method Based On Single Valued Neutrosophic T-Representable T-Norm: Purposes, Strategies, And A Proof-Of-Principle Study, Minxia Luo, Ziyang Sun, Donghui Xu, Lixian Wu
Neutrosophic Systems with Applications
As a generalization of intuitionistic fuzzy sets, single-valued neutrosophic sets have certain advantages in solving indeterminate and inconsistent information. In this paper, we study the fuzzy inference full implication method based on single-valued neutrosophic t-representable t-norm. Firstly, single-valued neutrosophic fuzzy inference triple I principles for fuzzy modus ponens and fuzzy modus tollens are given. Then, single-valued neutrosophic R-type triple I solutions for FMP and FMT are given. Finally, the robustness of the full implication triple I method based on the left-continuous single-valued neutrosophic t-representable t-norm is investigated. As a special case of the main results, the sensitivity of full implication …
Pairing New Approach Of Tree Soft With Mcdm Techniques: Toward Advisory An Outstanding Web Service Provider Based On Qos Levels, Sara Fawaz Al-Baker, Ibrahim El-Henawy, Mona Mohamed
Pairing New Approach Of Tree Soft With Mcdm Techniques: Toward Advisory An Outstanding Web Service Provider Based On Qos Levels, Sara Fawaz Al-Baker, Ibrahim El-Henawy, Mona Mohamed
Neutrosophic Systems with Applications
Web services (WSs) have become dynamic because of technological advancements and internet usage. Hence, selecting a WS provider among a variety of WS providers that perform the same function is a critical process. However, the crucial point is that various consumers may have varied needs when it comes to the quality attributes of services, such as cost, response time, throughput, security, availability, etc. These aspects of Web services are known as quality of service (QoS), or non-functional characteristics. Hence, this issue is the robust motivator for conducting this study. The objective of this study is to evaluate a set of …
Finding A Basic Feasible Solution For Neutrosophic Linear Programming Models: Case Studies, Analysis, And Improvements, Maissam Jdid, Florentin Smarandache
Finding A Basic Feasible Solution For Neutrosophic Linear Programming Models: Case Studies, Analysis, And Improvements, Maissam Jdid, Florentin Smarandache
Neutrosophic Systems with Applications
Since the inception of operations research, linear programming has received the attention of researchers in this field due to the many areas of its use. The focus was on the methods used to find the optimal solution for linear models. The direct simplex method, with its three basic stages, begins by writing the linear model in standard form and then finding a basic solution that is improved according to the simplex steps until We get the optimal solution, but we encounter many linear models that do not give us a basic solution after we put it in a standard form, …
Study Of Dusty Torus In The Vicinity Of Active Supermassive Black Holes, Arya Sudhakaran
Study Of Dusty Torus In The Vicinity Of Active Supermassive Black Holes, Arya Sudhakaran
University Departments
No abstract provided.
Study Of Soalr Atmospheric Heating Due To Active Regions, Munjiba M. M
Study Of Soalr Atmospheric Heating Due To Active Regions, Munjiba M. M
University Departments
No abstract provided.
The Energy Of Interval-Valued Complex Neutrosophic Graph Structures: Framework, Application And Future Research Directions, S.N. Suber Bathusha, Sowndharya Jayakumar, S. Angelin Kavitha Raj
The Energy Of Interval-Valued Complex Neutrosophic Graph Structures: Framework, Application And Future Research Directions, S.N. Suber Bathusha, Sowndharya Jayakumar, S. Angelin Kavitha Raj
Neutrosophic Systems with Applications
Graph structure is a developing field with many real-world applications and advancements, particularly effective frameworks for integrative problem-solving in computer networks and artificial intelligence systems. To define the idea of an Interval-Valued Complex Neutrosophic Graph Structure (IVCNGS), the concept of an Interval-Valued Complex Neutrosophic Set (IVCNS) is applied to the graph structure. Using the adjacency matrix to calculate the degree of vertex, we have defined some findings about the IVCNGS. Further, we compute the energy and Laplacian energy of IVCNGS. Moreover, we derive the lower and upper bounds for the energy and Laplacian energy of IVCNGS, and we have discussed …
Determination Of Thermal Neutron Capture Cross Sections Of Cerium Isotopes, Samrudhi R. Kanjarpane
Determination Of Thermal Neutron Capture Cross Sections Of Cerium Isotopes, Samrudhi R. Kanjarpane
University Departments
No abstract provided.
The Energy Of Interval-Valued Complex Neutrosophic Graph Structures: Framework, Application And Future Research Directions, S.N. Suber Bathusha, Sowndharya Jayakumar, S. Angelin Kavitha Raj
The Energy Of Interval-Valued Complex Neutrosophic Graph Structures: Framework, Application And Future Research Directions, S.N. Suber Bathusha, Sowndharya Jayakumar, S. Angelin Kavitha Raj
Neutrosophic Systems with Applications
Graph structure is a developing field with many real-world applications and advancements, particularly effective frameworks for integrative problem-solving in computer networks and artificial intelligence systems. To define the idea of an Interval-Valued Complex Neutrosophic Graph Structure (IVCNGS), the concept of an Interval-Valued Complex Neutrosophic Set (IVCNS) is applied to the graph structure. Using the adjacency matrix to calculate the degree of vertex, we have defined some findings about the IVCNGS. Further, we compute the energy and Laplacian energy of IVCNGS. Moreover, we derive the lower and upper bounds for the energy and Laplacian energy of IVCNGS, and we have discussed …
Internal Parametricity, Without An Interval, Thorsten Altenkirch, Yorgo Chamoun, Ambrus Kaposi, Michael Shulman
Internal Parametricity, Without An Interval, Thorsten Altenkirch, Yorgo Chamoun, Ambrus Kaposi, Michael Shulman
Mathematics: Faculty Scholarship
Parametricity is a property of the syntax of type theory implying, e.g., that there is only one function having the type of the polymorphic identity function. Parametricity is usually proven externally, and does not hold internally. Internalising it is difficult because once there is a term witnessing parametricity, it also has to be parametric itself and this results in the appearance of higher dimensional cubes. In previous theories with internal parametricity, either an explicit syntax for higher cubes is present or the theory is extended with a new sort for the interval. In this paper we present a type theory …
Final 2023 Butte Priority Soils Operable Unit Type B Borrow Material Submittal #1, Pioneer Technical Services, Inc.
Final 2023 Butte Priority Soils Operable Unit Type B Borrow Material Submittal #1, Pioneer Technical Services, Inc.
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Young Professionals: Fireside Chat With Jacques Lewiner And J. Keith Nelson At The Ieee Conference On Electrical Insulation And Dielectric Phenomena, Mattewos Tefferi, Allen Andersen, Sneha Hedge, Moein Borghei
Young Professionals: Fireside Chat With Jacques Lewiner And J. Keith Nelson At The Ieee Conference On Electrical Insulation And Dielectric Phenomena, Mattewos Tefferi, Allen Andersen, Sneha Hedge, Moein Borghei
Journal Articles
At the IEEE Conference on Electrical Insulation and Dielectric Phenomena (CEIDP), the Dielectrics and Electrical Insulation Society’s Young Professionals (DEIS-YP) Committee has initiated a YP luncheon event. This event aims to feature keynote speakers who share insights into their career trajectories with young professionals. In the current CEIDP edition, we had the privilege of hosting two distinguished speakers: Jacques Lewiner, the 2023 Whitehead Memorial Lecturer, and J. Keith Nelson, the 2022 recipient of the Dakin Award who also presented his award lecture at the CEIDP 2023. The fire- side chat was moderated by Allen Andersen, who began with initial questions …
Questioning Reality: The Progressive Development Of Modern Physics, Joshua Lancman
Questioning Reality: The Progressive Development Of Modern Physics, Joshua Lancman
STEM for Success Showcase
Humanity has a tendency to divide time. The past is distinct from the present which is entirely separate from the future. In supposedly 20-20 vision history is neatly divided into different sections, distinct eras with sharp lines between them. What is present and in the future is always modern. What is past is something else with another name.
Yet time is not divided so neatly. We know this living through it: years and decades blend into one another in a non-uniform progression. To divide human history into separate eras is a necessary simplification, as it helps to ascribe order onto …
Gwtc-2.1: Deep Extended Catalog Of Compact Binary Coalescences Observed By Ligo And Virgo During The First Half Of The Third Observing Run, R. Abbott, T. D. Abbott, F. Acernese, K. Ackley, Teviet Creighton, Mario C. Diaz, Francisco Llamas, Soma Mukherjee, Volker Quetschke, Wenhui Wang
Gwtc-2.1: Deep Extended Catalog Of Compact Binary Coalescences Observed By Ligo And Virgo During The First Half Of The Third Observing Run, R. Abbott, T. D. Abbott, F. Acernese, K. Ackley, Teviet Creighton, Mario C. Diaz, Francisco Llamas, Soma Mukherjee, Volker Quetschke, Wenhui Wang
Physics & Astronomy Faculty Publications
The second Gravitational-Wave Transient Catalog, GWTC-2, reported on 39 compact binary coalescences observed by the Advanced LIGO and Advanced Virgo detectors between 1 April 2019 15∶00 UTC and 1 October 2019 15∶00 UTC. Here, we present GWTC-2.1, which reports on a deeper list of candidate events observed over the same period. We analyze the final version of the strain data over this period with improved calibration and better subtraction of excess noise, which has been publicly released. We employ three matched-filter search pipelines for candidate identification, and estimate the probability of astrophysical origin for each candidate event. While GWTC-2 used …
Stemdriver: A Knowledgebase Of Gene Functions For Hematopoietic Stem Cell Fate Determination, Kexin Huang, Yang Liu, Grant Wang, Ruihan Luo, Ting Niu, Yuzhou Feng, Haixia Xu, Pora Kim, Xiaobo Zhou
Stemdriver: A Knowledgebase Of Gene Functions For Hematopoietic Stem Cell Fate Determination, Kexin Huang, Yang Liu, Grant Wang, Ruihan Luo, Ting Niu, Yuzhou Feng, Haixia Xu, Pora Kim, Xiaobo Zhou
Faculty, Staff and Student Publications
StemDriver is a comprehensive knowledgebase dedicated to the functional annotation of genes participating in the determination of hematopoietic stem cell fate, available at http://biomedbdc.wchscu.cn/StemDriver/. By utilizing single-cell RNA sequencing data, StemDriver has successfully assembled a comprehensive lineage map of hematopoiesis, capturing the entire continuum from the initial formation of hematopoietic stem cells to the fully developed mature cells. Extensive exploration and characterization were conducted on gene expression features corresponding to each lineage commitment. At the current version, StemDriver integrates data from 42 studies, encompassing a diverse range of 14 tissue types spanning from the embryonic phase to adulthood. In order …
Fusionpdb:: A Knowledgebase Of Human Fusion Proteins
Fusionpdb:: A Knowledgebase Of Human Fusion Proteins
Faculty, Staff and Student Publications
Tumorigenic functions due to the formation of fusion genes have been targeted for cancer therapeutics (i.e. kinase inhibitors). However, many fusion proteins involved in various cellular processes have not been studied for targeted therapeutics. This is because the lack of complete fusion protein sequences and their whole 3D structures has made it challenging to develop new therapeutic strategies. To fill these critical gaps, we developed a computational pipeline and a resource of human fusion proteins named FusionPDB, available at https://compbio.uth.edu/FusionPDB. FusionPDB is organized into four levels: 43K fusion protein sequences (14.7K in-frame fusion genes, Level 1), over 2300 + 1267 …
Ageannomo: A Knowledgebase Of Multi-Omics Annotation For Animal Aging, Haixia Xu, Qingxuan Li, Yuhao Jia, Liyu Huang, Pora Kim, Xiaobo Zhou
Ageannomo: A Knowledgebase Of Multi-Omics Annotation For Animal Aging, Haixia Xu, Qingxuan Li, Yuhao Jia, Liyu Huang, Pora Kim, Xiaobo Zhou
Faculty, Staff and Student Publications
Aging entails gradual functional decline influenced by interconnected factors. Multiple hallmarks proposed as common and conserved underlying denominators of aging on the molecular, cellular and systemic levels across multiple species. Thus, understanding the function of aging hallmarks and their relationships across species can facilitate the translation of anti-aging drug development from model organisms to humans. Here, we built AgeAnnoMO (https://relab.xidian.edu.cn/AgeAnnoMO/#/), a knowledgebase of multi-omics annotation for animal aging. AgeAnnoMO encompasses an extensive collection of 136 datasets from eight modalities, encompassing 8596 samples from 50 representative species, making it a comprehensive resource for aging and longevity research. AgeAnnoMO characterizes …
Fusionneoantigen: : A Resource Of Fusion Gene-Specific Neoantigens, Xiaobo Zhou, Pora Kim
Fusionneoantigen: : A Resource Of Fusion Gene-Specific Neoantigens, Xiaobo Zhou, Pora Kim
Faculty, Staff and Student Publications
Among the diverse sources of neoantigens (i.e. single-nucleotide variants (SNVs), insertions or deletions (Indels) and fusion genes), fusion gene-derived neoantigens are generally more immunogenic, have multiple targets per mutation and are more widely distributed across various cancer types. Therefore, fusion gene-derived neoantigens are a potential source of highly immunogenic neoantigens and hold great promise for cancer immunotherapy. However, the lack of fusion protein sequence resources and knowledge prevents this application. We introduce 'FusionNeoAntigen', a dedicated resource for fusion-specific neoantigens, accessible at https://compbio.uth.edu/FusionNeoAntigen. In this resource, we provide fusion gene breakpoint crossing neoantigens focused on ∼43K fusion proteins of ∼16K in-frame …
Cov2var, A Function Annotation Database Of Sars-Cov-2 Genetic Variation, Jianguo Wen, Weiling Zhao, Pora Kim, Xiaobo Zhou
Cov2var, A Function Annotation Database Of Sars-Cov-2 Genetic Variation, Jianguo Wen, Weiling Zhao, Pora Kim, Xiaobo Zhou
Faculty, Staff and Student Publications
The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has resulted in the loss of millions of lives and severe global economic consequences. Every time SARS-CoV-2 replicates, the viruses acquire new mutations in their genomes. Mutations in SARS-CoV-2 genomes led to increased transmissibility, severe disease outcomes, evasion of the immune response, changes in clinical manifestations and reducing the efficacy of vaccines or treatments. To date, the multiple resources provide lists of detected mutations without key functional annotations. There is a lack of research examining the relationship between mutations and various factors such as disease severity, pathogenicity, patient age, patient gender, cross-species …
Drmref: Comprehensive Reference Map Of Drug Resistance Mechanisms In Human Cancer, Kexin Huang, Jiajia Liu, Grant Wang, Pora Kim, Qianqian Song, Xiaobo Zhou
Drmref: Comprehensive Reference Map Of Drug Resistance Mechanisms In Human Cancer, Kexin Huang, Jiajia Liu, Grant Wang, Pora Kim, Qianqian Song, Xiaobo Zhou
Faculty, Staff and Student Publications
Drug resistance poses a significant challenge in cancer treatment. Despite the initial effectiveness of therapies such as chemotherapy, targeted therapy and immunotherapy, many patients eventually develop resistance. To gain deep insights into the underlying mechanisms, single-cell profiling has been performed to interrogate drug resistance at cell level. Herein, we have built the DRMref database (https://ccsm.uth.edu/DRMref/) to provide comprehensive characterization of drug resistance using single-cell data from drug treatment settings. The current version of DRMref includes 42 single-cell datasets from 30 studies, covering 382 samples, 13 major cancer types, 26 cancer subtypes, 35 treatment regimens and 42 drugs. All datasets in …