Physical Sciences and Mathematics Commons^™

A Comparative Study Of Responses To Retina Questions From Either Experts, Expert-Edited Large Language Models, Or Expert-Edited Large Language Models Alone, Prashant D. Tailor, Lauren A. Dalvin, John J. Chen, Raymond Iezzi, Timothy W. Olsen, Brittni A. Scruggs, Andrew J. Barkmeier, Sophie J. Bakri, Edwin H. Ryan, Peter H. Tang, D. Wilkin Parke, Peter Belin, Jayanth Sridhar, David Xu, Ajay E. Kuriyan, Yoshihiro Yonekawa, Matthew R. Starr

Wills Eye Hospital Papers

OBJECTIVE: To assess the quality, empathy, and safety of expert edited large language model (LLM), human expert created, and LLM responses to common retina patient questions.

DESIGN: Randomized, masked multicenter study.

PARTICIPANTS: Twenty-one common retina patient questions were randomly assigned among 13 retina specialists.

METHODS: Each expert created a response (Expert) and then edited a LLM (ChatGPT-4)-generated response to that question (Expert + artificial intelligence [AI]), timing themselves for both tasks. Five LLMs (ChatGPT-3.5, ChatGPT-4, Claude 2, Bing, and Bard) also generated responses to each question. The original question along with anonymized and randomized Expert + AI, Expert, and LLM …

Computational Study Of Binding Of Oseltamivir To Neuraminidase Mutants Of Influenza A Virus, Muhammad Arba, Sri Wahyuli, Setyanto Tri Wahyudi, Amir Karton, Chun Wu

College of Science & Mathematics Departmental Research

Oseltamivir (OTV), which targets the neuraminidase (NA) of Influenza A virus (IAV), has been reported to develop resistance. Here, we performed a computational study on the binding modes of OTV in the wild-type and popular mutants of IAV NA (E119A, E119D, E119G, H274Y, I117T, I117V, I117V-E119A, K150N, N294S, R292K, V116A, and Y252H). The Arg118, Glu119, Asp151, Arg152, Glu276, Arg292, and Arg371 were identified as crucial interacting residues with the drug. The energy decomposition analysis showed that with few exceptions, the dispersion interaction is the dominant interaction, followed by the charge-transfer and polarization interactions. The affinities for OTV were greatly reduced …

Two-Photon Absorption And Fluorescence Of Cadmium Sulfide, Jacob Goranson, Gregory J. Taft

Physics Faculty Publications

The two-photon absorption and fluorescence of bulk cadmium sulfide were studied using 50-fs, 800-nm pulses from an unamplified Ti:sapphire laser. The fluorescence spectrum was measured to have a main peak at 522 nm, and the power of the fluorescence was shown to vary quadratically with the 800-nm beam power. This supports the theory that the fluorescence is excited by two-photon absorption and confirms previous work done with longer duration, higher energy excitation pulses. Pump-probe measurements provided additional confirmation of the two-photon absorption. Measured spectral broadening of the wings of the laser spectrum also was observed, which likely is due to …

Harnessing The Synergy Of Fe And Co With Carbon Nanofibers For Enhanced Co, Kevin Arizapana, John Schossig, Michael Wildy, Daniel Weber, Akash Gandotra, Sumedha Jayaraman, Wanying Wei, Kai Xu, Lei Yu, Amos M Mugweru, Islam Mantawy, Cheng Zhang, Ping Lu

College of Science & Mathematics Departmental Research

Amid growing concerns about climate change and energy sustainability, the need to create potent catalysts for the sequestration and conversion of CO2 to value-added chemicals is more critical than ever. This work describes the successful synthesis and profound potential of high-performance nanofiber catalysts, integrating earth-abundant iron (Fe) and cobalt (Co) as well as their alloy counterpart, FeCo, achieved through electrospinning and judicious thermal treatments. Systematic characterization using an array of advanced techniques, including SEM, TGA-DSC, ICP-MS, XRF, EDS, FTIR–ATR, XRD, and Raman spectroscopy, confirmed the integration and homogeneous distribution of Fe/Co elements in nanofibers and provided insights into their catalytic …

Unusual Catalytic Strategy By Non-Heme Fe(Ii)/2-Oxoglutarate-Dependent Aspartyl Hydroxylase Asph, Anandhu Krishnan, Sodiq Waheed, Ann Varghese, Fathima Hameed Cherilakkudy, Christopher J. Schofield, Tatyana G. Karabencheva-Christova

Michigan Tech Publications

Biocatalytic C-H oxidation reactions are of important synthetic utility, provide a sustainable route for selective synthesis of important organic molecules, and are an integral part of fundamental cell processes. The multidomain non-heme Fe(ii)/2-oxoglutarate (2OG) dependent oxygenase AspH catalyzes stereoselective (3R)-hydroxylation of aspartyl- and asparaginyl-residues. Unusually, compared to other 2OG hydroxylases, crystallography has shown that AspH lacks the carboxylate residue of the characteristic two-His-one-Asp/Glu Fe-binding triad. Instead, AspH has a water molecule that coordinates Fe(ii) in the coordination position usually occupied by the Asp/Glu carboxylate. Molecular dynamics (MD) and quantum mechanics/molecular mechanics (QM/MM) studies reveal that the iron coordinating water is …

Maximizing Charge Dynamics In Znin2s4/Cn Van Der Waals Heterojunction For Optimal Hydrogen Production From Photoreforming Of Glucose, Jinqiang Zhang, Xinyuan Xu, Lei Shi, Huayang Zhang, Shaobin Wang, Hongqi Sun

Research outputs 2022 to 2026

Biomass photoreforming stands out as a promising avenue for green hydrogen, leveraging solar energy for the generation and transformation of clean and renewable energy resources. The pursuit of efficient photocatalysts is motivated by the unsatisfied hydrogen evolution performance arising from the complex and stubborn structure of biomass. Herein, we loaded 2-dimensional (2D) ZnIn2S4 onto 2D carbon nitride nanosheets, resulting in the formation of Van der Waals (VDW) heterojunctions (ZIS/CN). Band structure and morphology of CN were rationally tailored through precursor engineering to effectively magnify interfacial internal electric field and minimize diffusion pathway within the VDW heterostructure, realizing optimal charge dynamics …

Real-World Trends, Rural-Urban Differences, And Socioeconomic Disparities In Utilization Of Narrow Versus Broad Next-Generation Sequencing Panels, Yiqing Zhao, Anastasios Dimou, Zachary C Fogarty, Jun Jiang, Hongfang Liu, William B Wong, Chen Wang

Faculty, Staff and Student Publications

UNLABELLED: Advances in genetic technology have led to the increasing use of genomic panels in precision oncology practice, with panels ranging from a couple to hundreds of genes. However, the clinical utilization and utility of oncology genomic panels, especially among vulnerable populations, is unclear. We examined the association of panel size with socioeconomic status and clinical trial matching. We retrospectively identified 9,886 eligible adult subjects in the Mayo Clinic Health System who underwent genomic testing between January 1, 2016 and June 30, 2020. Patient data were retrieved from structured and unstructured data sources of institutional collections, including cancer registries, clinical …

Residential Metals Abatement Program Investigation Summary Report (Non-Residential Parcels – Indoor Dust) - Gold Hill Lutheran Church (Creativity Factory Preschool), Environmental Resource Management (Erm)

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Final 2024 Residential Metals Abatement Program (Rmap) Whitehall Borrow Submittal #2, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Multi-Agent System For Portfolio Profit Optimization For Future Stock Trading, Usha Devi, Mohan R

Karbala International Journal of Modern Science

Stock trading highly contributes to the economic growth of the country. The stock trading objective is to earn profits with buy/sell/hold decisions on the set of stocks in the portfolio. The portfolio optimization problem is finding the decision sequence that leads to higher profit and lower risk. Portfolio optimization is challenging due to complex price history patterns and an uncertain environment. Incorrect decisions in stock trading lead to massive losses. The proposed Multi-Agent System for Portfolio Profit Optimization (MASPPO) aims to optimize trading profit and reduce risk with accurate predictions. The proposed model integrates the Fuzzy c-means with the Deep …

Use Of Dft Calculations As A Tool For Designing New Solvatochromic Probes For Biological Applications, Cynthia M. Dupureur

Educator Preparation & Leadership Faculty Works

The intramolecular charge transfer behavior of push–pull dyes is the origin of their sensitivity to environment. Such compounds are of interest as probes for bioimaging and as biosensors to monitor cellular dynamics and molecular interactions. Those that are solvatochromic are of particular interest in studies of lipid dynamics and heterogeneity. The development of new solvatochromic probes has been driven largely by the need to tune desirable properties such as solubility, emission wavelength, or the targeting of a particular cellular structure. DFT calculations are often used to characterize these dyes. However, if a correlation between computed (dipole moment) and experimentally measured …

Degradation Of The Mechanical Properties And Hydrogen Generation In Cement Under Gamma Irradiation Assessed By Atomistic Simulation, Omar Al Najjar

Theses and Dissertations

Although understanding the effect of the gamma-ray on cement-based materials is essential for many applications, such as the concrete contaminate of nuclear reactors or the storage of radioactive waste in cement-based waste forms, such understanding is still not fully developed. The importance of having such an understanding is becoming of utmost importance, especially with calls to extend the lifetime of nuclear power plants, and also due to some recent incidents of failures of the concrete structure in the nuclear fields. In this work, the details of preparing three molecular models as a representative structure of the main binding phase of …

Identification Of New Egfr Inhibitors By Structure-Based Virtual Screening And Biological Evaluation, Shuyi Wang, Xiaotian Xu, Chuxin Pan, Qian Guo, Qinlan Li, Shanhe Wan, Zhonghuang Li, Jiajie Zhang, Xiaoyun Wu

Faculty, Staff and Student Publications

Epidermal growth factor receptor (EGFR) inhibitors have been used in clinical for the treatment of non-small-cell lung cancer for years. However, the emergence of drug resistance continues to be a major problem. To identify potential inhibitors, molecular docking-based virtual screening was conducted on ChemDiv and Enamine commercial databases using the Glide program. After multi-step VS and visual inspection, a total of 23 compounds with novel and varied structures were selected, and the predicted ADMET properties were within the satisfactory range. Further molecular dynamics simulations revealed that the reprehensive compound ZINC49691377 formed a stable complex with the allosteric pocket of EGFR …

Emoji Use In Social Media Posts: Relationships With Personality Traits And Word Usage, Shelia Kennison, Kameryn Fritz, Maria Andrea Hurtado Morales, Eric Chan-Tin

Computer Science: Faculty Publications and Other Works

Prior research has demonstrated relationships between personality traits of social media users and the language used in their posts. Few studies have examined whether there are relationships between personality traits of users and how they use emojis in their social media posts. Emojis are digital pictographs used to express ideas and emotions. There are thousands of emojis, which depict faces with expressions, objects, animals, and activities. We conducted a study with two samples (n = 76 and n = 245) in which we examined how emoji use on X (formerly Twitter) related to users’ personality traits and language use …

Flavors And Frailties Of Globalization, Nikhilesh Dholakia, Deniz Atik

Markets, Globalization & Development Review

No abstract provided.

Protein And Polysaccharide-Based Optical Materials For Biomedical Applications., Gianna Riviello, Brendan Connor, Jake Mcbrearty, Gianna Rodriguez, Xiao Hu

College of Science & Mathematics Departmental Research

Recent advances in biomedical research, particularly in optical applications, have sparked a transformative movement towards replacing synthetic polymers with more biocompatible and sustainable alternatives. Most often made from plastics or glass, these materials ignite immune responses from the body, and their production is based on environmentally harsh oil-based processes. Biopolymers, including both polysaccharides and proteins, have emerged as a potential candidate for optical biomaterials due to their inherent biocompatibility, biodegradability, and sustainability, derived from their existence in nature and being recognized by the immune system. Current extraction and fabrication methods for these biomaterials, including thermal drawing, extrusion and printing, mold …

The Santa Clara, 2024-02-02, Santa Clara University

The Santa Clara

No abstract provided.

Developing A Remote Gamma-Ray Spectra Collection System (Rgscs) By Coupling A High Purity Germanium (Hpge) Detector With A Cosmicguard Background Reduction Device, Zaijing Sun, Krishnakumar Divakar Nangeelil, Haven Searcy

Health Physics and Diagnostic Sciences Faculty Research

Despite being widely used for high-resolution spectral analysis and quantifying low activity in natural samples, the operations and data analysis of High Purity Germanium (HPGe) gamma-ray detectors are seldom fully automated due to the excessive costs associated with commercially available automatic sample changing systems. This paper introduces the design and implementation of a cost-effective, customized remote gamma-ray spectra collection system centered around the HPGe detector coupled to a cosmic-ray veto background reduction device. The HPGe detector system, equipped with a Lynx DSA, is seamlessly integrated with an economically viable automatic sample changer. This sample vial changer is controlled by a …

Blood Cell Image Segmentation And Classification: A Systematic Review, Muhammad Shahzad, Farman Ali, Syed Hamad Shirazi, Assad Rasheed, Awais Ahmad, Babar Shah, Daehan Kwak

All Works

Background Blood diseases such as leukemia, anemia, lymphoma, and thalassemia are hematological disorders that relate to abnormalities in the morphology and concentration of blood elements, specifically white blood cells (WBC) and red blood cells (RBC). Accurate and efficient diagnosis of these conditions significantly depends on the expertise of hematologists and pathologists. To assist the pathologist in the diagnostic process, there has been growing interest in utilizing computer-aided diagnostic (CAD) techniques, particularly those using medical image processing and machine learning algorithms. Previous surveys in this domain have been narrowly focused, often only addressing specific areas like segmentation or classification but lacking …

Fiber-Based Speckle Contrast Optical Tomography In Humans, Chen-Hao Lin

Arts & Sciences Graduate Student Theses and Dissertations

Cerebral blood flow (CBF) is an important biomarker for indicating many brain diseases, such as stroke and traumatic brain injury. Therefore, the development of real-time CBF measures in the clinic is desired, and many techniques have been developed to measure CBF. However, the current standard techniques, including positron emission tomography (PET), arterial spin labeling magnetic resonance imaging (ASL-MRI), and computed tomography (CT) perfusion are limited to the high instrument cost, massive size, and the requirement of ionizing radiation, and thus are not able to map CBF at the bedside. Furthermore, these techniques offer only snapshots due to scanner logistics. An …

Analysis Of The Impact Of Water Treatment By Liming Sedimentation And Dredging On The Content Of Heavy Metals In Fish Intended For Consumption, Asfie Maidie, Ismail Fahmy Almadi, Muchlis Efendi, Rekha Yusdha Nilawardhani, Komsanah Sukarti, Henny Pagoray

Journal of Sustainable Mining

The present study sought to determine the presence of metals and arsenic, a metalloid, among the fish of a coal mine reservoir, where the water was treated regularly through liming sedimentation combined with dredging, and the fish living in an adjoining river. The potential hazard of metals in fish as human food was analyzed. Except for selenium (an important metal to the human body), which was higher among the river fish than in the reservoir fish (P < 0.01), there were no particular patterns of other studied metals found in either habitat (P > 0.05), and apparently not related to the fish family that consumed by local people. Measurements of bioaccumulation factor (BAF) yielded scattered values from …

Conic Challenge: Pushing The Frontiers Of Nuclear Detection, Segmentation, Classification And Counting, Simon Graham, Quoc Dang Vu, Mostafa Jahanifar, Martin Weigert, Uwe Schmidt, Wenhua Zhang, Jun Zhang, Sen Yang, Jinxi Xiang, Xiyue Wang, Josef Lorenz Rumberger, Elias Baumann, Peter Hirsch, Lihao Liu, Chenyang Hong, Angelica I. Aviles-Rivero, Ayushi Jain, Heeyoung Ahn, Yiyu Hong, Hussam Azzuni, Min Xu

Computer Vision Faculty Publications

Nuclear detection, segmentation and morphometric profiling are essential in helping us further understand the relationship between histology and patient outcome. To drive innovation in this area, we setup a community-wide challenge using the largest available dataset of its kind to assess nuclear segmentation and cellular composition. Our challenge, named CoNIC, stimulated the development of reproducible algorithms for cellular recognition with real-time result inspection on public leaderboards. We conducted an extensive post-challenge analysis based on the top-performing models using 1,658 whole-slide images of colon tissue. With around 700 million detected nuclei per model, associated features were used for dysplasia grading and …

Using Natural Language Processing And Patient Journey Clustering For Temporal Phenotyping Of Antimicrobial Therapies For Cat Bite Abscesses, Brian Hur, Karin M. Verspoor, Timothy Baldwin, Laura Y. Hardefeldt, Caitlin Pfeiffer, Caroline Mansfield, Riati Scarborough, James R. Gilkerson

Natural Language Processing Faculty Publications

Background: Temporal phenotyping of patient journeys, which capture the common sequence patterns of interventions in the treatment of a specific condition, is useful to support understanding of antimicrobial usage in veterinary patients. Identifying and describing these phenotypes can inform antimicrobial stewardship programs designed to fight antimicrobial resistance, a major health crisis affecting both humans and animals, in which veterinarians have an important role to play. Objective: This research proposes a framework for extracting temporal phenotypes of patient journeys from clinical practice data through the application of natural language processing (NLP) and unsupervised machine learning (ML) techniques, using cat bite abscesses …

Fuzzy Ideas Explain Fechner Law And Help Detect Relation Between Objects In Video, Olga Kosheleva, Vladik Kreinovich, Ahnaf Farhan

Departmental Technical Reports (CS)

How to find relation between objects in a video? If two objects are closely related -- e.g., a computer and it mouse -- then they almost always appear together, and thus, their numbers of occurrences are close. However, simply computing the differences between numbers of occurrences is not a good idea: objects with 100 and 110 occurrences are most probably related, but objects with 1 and 5 occurrences probably not, although 5 − 1 is smaller than 110 − 100. A natural idea is, instead, to compute the difference between re-scaled numbers of occurrences, for an appropriate nonlinear re-scaling. In …

Modifed Playfair For Text File Encryption And Meticulous Decryption With Arbitrary Fillers By Septenary Quadrate Pattern, N. Sugirtham, R. Sherine Jenny, B. Thiyaneswaran, S. Kumarganesh, C. Venkatesan, K. Martin Sagayam, Lam Dang, Linh Dinh, Helen Dang

Mathematics and Computer Studies: Faculty Publications

Cryptography secures data and serves to ensure the confidentiality of records. Playfair is a cryptographic symmetrical algorithm that encrypts statistics based on key costs. This secret is shared with an authorized person to retrieve data. In the conventional pattern, there is an area complexity and deficiency in letters, numbers, and special characters. This hassle has been overcome in previous studies by editing pattern dimensions. The fillers used throughout the enciphering were not eliminated during the retrieval process, which resulted in the indiscrimination of the retrieved statistics. The proposed method uses a separate quadrate pattern that strengthens the Playfair cipher and …

Association Of Alpha-Crystallin With Human Cortical And Nuclear Lens Lipid Membrane Increases With The Grade Of Cortical And Nuclear Cataract, Preston Hazen, Geraline Trossi-Torres, Raju Timsina, Nawal K. Khadka, Laxman Mainali

Physics Faculty Publications and Presentations

Eye lens α-crystallin has been shown to become increasingly membrane-bound with age and cataract formation; however, to our knowledge, no studies have investigated the membrane interactions of α-crystallin throughout the development of cataracts in separated cortical membrane (CM) and nuclear membrane (NM) from single human lenses. In this study, four pairs of human lenses from age-matched male and female donors and one pair of male lenses ranging in age from 64 to 73 years old (yo) were obtained to investigate the interactions of α-crystallin with the NM and CM throughout the progression of cortical cataract (CC) and nuclear cataract (NC) …

Long Term Sustainable Use Of Demersal Gillnet And Demersal Longline In Western Australia’S Temperate Shark Fisheries - Fisheries Research Report 340, Matias Braccini, Jack Parker, Daniela Waltrick, Maddison Watt, Nick Blay, Clinton Syers

Fisheries Research Reports

The Temperate Demersal Gillnet and Demersal Longline Fisheries (TDGDLF) are one of the main commercial shark fisheries in Australia. Most fishers in the TDGDLF use demersal gillnets to target sharks with scalefish taken in smaller amounts. Demersal longlines are also permitted but are not widely used. Demersal gillnets are size selective, but they do not necessarily discriminate among species, catching target and non-target species.

The Western Australian Fishing Industry Council (WAFIC) received funding as part of the Australian Government’s Our Marine Parks Grants Program to undertake research on the TDGDLF. This project was administered under the direction of a steering …

Fisheries Research Report No. 339: Assessment Of The Status Of The South Coast Demersal Scalefish Resource, Jeffrey V. Norriss, Sybrand A. Hesp, David V. Fairclough, Rubie Evans-Powell, B. Hancock, Emily A. Fisher, Tim Leary, Nick Jarvis

Fisheries Research Reports

This document provides the 2023 risk-based weight of evidence stock assessments for snapper, Bight redfish, hapuku, blue morwong, and Western blue groper for 2023 in the South Coast Bioregion (SCB).

Spontaneous Transfer Of Small Peripheral Peptides Between Supported Lipid Bilayer And Giant Unilamellar Vesicles, Emanuela Efodili, Ashlynn Knight, Maryem Mirza, Cedric Briones, Il Hyung Lee

Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works

Vesicular trafficking facilitates material transport between membrane-bound organelles. Membrane protein cargos are trafficked for relocation, recycling, and degradation during various physiological processes. In vitro fusion studies utilized synthetic lipid membranes to study the molecular mechanisms of vesicular trafficking and to develop synthetic materials mimicking the biological membrane trafficking. Various fusogenic conditions which can induce vesicular fusion have been used to establish synthetic systems that can mimic biological systems. Despite these efforts, the mechanisms underlying vesicular trafficking of membrane proteins remain limited and robust in vitro methods that can construct synthetic trafficking systems for membrane proteins between large membranes (>1 …

Experimental Sars-Cov-2 Infection Of Elk And Mule Deer, Stephanie M. Porter, Airn E. Hartwig, Helle Bielefeldt-Ohmann, Jeffrey M. Marano, J. Jeffrey Root, Angela M. Bosco-Lauth

United States Department of Agriculture Wildlife Services: Staff Publications

To assess the susceptibility of elk (Cervus canadensis) and mule deer (Odocoileus hemionus) to SARS-CoV-2, we performed experimental infections in both species. Elk did not shed infectious virus but mounted low-level serologic responses. Mule deer shed and transmitted virus and mounted pronounced serologic responses and thus could play a role in SARS-CoV-2 epidemiology.