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Articles 21421 - 21450 of 294629

Full-Text Articles in Physical Sciences and Mathematics

Modeling Of Light Filamentation For Nonlinear Imaging And Waveguiding, Nicholas Bagley Dec 2024

Modeling Of Light Filamentation For Nonlinear Imaging And Waveguiding, Nicholas Bagley

Mathematics Theses and Dissertations

Ultrashort pulses are capable of extremely high powers; in addition to enabling various applications in defense, sensing, and imaging, they provide a useful arena in which to study nonlinear optical phenomena that are observable only at high intensities. Due to these effects, which can include ionization and thermal blooming, simulation of ultrashort pulse propagation is a complicated multiphysics problem. We provide an overview of techniques used to simulate the propagation of ultrashort pulses in the nonlinear regime, including the formation of light filaments due to the competition of Kerr self-focusing and defocusing (e.g. via plasma generation). We discuss both carrier-resolved …

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Measuring And Improving Api Usability And Quality: A Comprehensive Framework And Empirical Study, Sultan Alanazy Dec 2024

Measuring And Improving Api Usability And Quality: A Comprehensive Framework And Empirical Study, Sultan Alanazy

Computer Science and Engineering Theses and Dissertations

Cloud computing provides on-demand access to flexible computing resources, enabling rapid application deployment without substantial infrastructure investment. Application Programming Interfaces (APIs) play an important role in ensuring the success of cloud applications. The primary users of APIs are the extensive community of application programmers who search, read, and understand APIs before integrating them into their applications or systems. In addition, developers often turn to online API support when seeking help. Problems in such support can result in incorrect API usage and integration problems. There is an urgent need to measure API usability and support issues to identify, characterize, and assess …

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Extraordinary 21st Century Drought In The Po River Basin (Italy), Abel Andrés Ramírez Molina, Glenn Tootle, Giuseppe Formetta, Thomas Piechota, Jiaqi Gong Dec 2024

Extraordinary 21st Century Drought In The Po River Basin (Italy), Abel Andrés Ramírez Molina, Glenn Tootle, Giuseppe Formetta, Thomas Piechota, Jiaqi Gong

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Recent research identified 2022 as being the year of lowest seasonal April–May–June–July (AMJJ) observed streamflow for the Po River Basin (PRB) in the past two centuries. Expanding upon this research, we applied filters (2-year to 30-year filters) to the AMJJ observed streamflow and identified the late 20th and 21st century as displaying extreme drought. In this study, we introduce PALEO-RECON, an automated reconstruction tool developed to leverage tree ring-based proxies and streamline regression processes. Using PALEO-RECON, we reconstructed the AMJJ streamflow, applying traditional regression techniques and using a nested approach in which 30-, 40-, and 50-year windows within the ~200-year …

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Summed Series Involving 1F2 Hypergeometric Functions, Jack C. Straton Dec 2024

Summed Series Involving 1F2 Hypergeometric Functions, Jack C. Straton

Physics Faculty Publications and Presentations

Summation of infinite series has played a significant role in a broad range of problems in the physical sciences and is of interest in a purely mathematical context. In a prior paper, we found that the Fourier–Legendre series of a Bessel function of the first kind JN(kx) and modified Bessel functions of the first kind IN(kx) lead to an infinite set of series involving 1F2 hypergeometric functions (extracted therefrom) that could be summed, having values that are inverse powers of the eight primes 1/ ( 2i 3j 5k …

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Parallel Circles: A Math Club As A University Math Circle, Sarah C. Cobb, Marcos Lopez Dec 2024

Parallel Circles: A Math Club As A University Math Circle, Sarah C. Cobb, Marcos Lopez

Journal of Math Circles

This paper will discuss a monthly social event for the University Math Club. Over the past several years, the event has been shaped by the philosophy of a Student Math Circle. We will discuss the event's organization and the ways it has benefited from the influence of the Math Circle community.

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Analysis Of Monthly And Annual Air Temperature Trends In Port-Said City, Egypt, Amna S. Dabbous, Yasser M. El-Wakeel, Tarek M. El-Geziry Dec 2024

Analysis Of Monthly And Annual Air Temperature Trends In Port-Said City, Egypt, Amna S. Dabbous, Yasser M. El-Wakeel, Tarek M. El-Geziry

Blue Economy

This study examined fluctuations in a long-term air temperature record in Port Said to determine the existence or absence of climate change in this significant Egyptian metropolis. The data period runs 31 years, from 1991 to 2021. The study investigated the homogeneity of the annual data and used a linear regression approach to characterize the trend of air temperature variations during the study period. Furthermore, the Mann-Kendall test was used to assess trend significance, as well as anomaly calculations to statistically specify severe air temperature episodes. The results showed that the data were homogeneous. Monthly mean air temperatures increased at …

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Optimization Of The Starch Chitosan-Based Flocculant Crosslinked By Ethylene Glycol Dimethacrylate On Removing Dypro 19 Textile Dye From Wastewater, Asep Nurohmat Majalis, Putri Ramadhani, Hendris Hendarsyah Kurniawan, Axel Dimaz Sanusi Pasaribu, Hafiizh Prasetia, Fitri Yuliani, Andreas Andreas, Hartati Hartati Dec 2024

Optimization Of The Starch Chitosan-Based Flocculant Crosslinked By Ethylene Glycol Dimethacrylate On Removing Dypro 19 Textile Dye From Wastewater, Asep Nurohmat Majalis, Putri Ramadhani, Hendris Hendarsyah Kurniawan, Axel Dimaz Sanusi Pasaribu, Hafiizh Prasetia, Fitri Yuliani, Andreas Andreas, Hartati Hartati

Karbala International Journal of Modern Science

Dyes used in industry, especially textile dyes, are one of the water pollutants that receive much attention because they are potentially toxic, carcinogenic, mutagenic, and generally challenging to decompose naturally. Textile dyes from wastewater can be removed through coagulation-flocculation. However, conventional coagulation-flocculation based on Fe and Al salts and synthetic polymers often leaves residual pollution. In this research, the performance of the new biopolymer-based flocculant, namely starch-ethylene glycol dimetacrylate-chitosan (SEC), which can act as coagulants and flocculants in solid-liquid separation of textile dyes, has been optimized using response surface methodology (RSM) approach. The influences of several independent variables, such …

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Breast Cancer Area Identification In Mammograms Using Expectation Maximization Gaussian Mixture Model, Rizki Khoirun Nisa, Dian Kurniasari, Favorisen R. Lumbanraja, Warsono Warsono Dec 2024

Breast Cancer Area Identification In Mammograms Using Expectation Maximization Gaussian Mixture Model, Rizki Khoirun Nisa, Dian Kurniasari, Favorisen R. Lumbanraja, Warsono Warsono

Karbala International Journal of Modern Science

Breast cancer accounts for 25% of all cancer diagnoses and 16% of cancer-related deaths among women globally, with high mortality rates due to late diagnosis. Early detection relies on imaging techniques such as mammography, histopathology, and breast ultrasound, with mammography being the gold standard due to its proven to detect breast cancer, thus it is effective for breast cancer treatment. However, mammogram images often produce noise and artefacts, complicating early-stage cancer detection and emphasizing the need for advanced image processing. Clustering algorithms such as K-means and Expectation Maximization - Gaussian Mixture Model (EM-GMM) have shown potential in image segmentation. This …

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A Fast Federated Learning-Based Crypto-Aggregation Scheme And Its Simulation Analysis, Boshen Lü, Xiao Song Dec 2024

A Fast Federated Learning-Based Crypto-Aggregation Scheme And Its Simulation Analysis, Boshen Lü, Xiao Song

Journal of System Simulation

Abstract: To solve the problem of increased computation and communication costs caused by using homomorphic encryption (HE) to protect all gradients in traditional cryptographic aggregation (cryptoaggregation) schemes, a fast crypto-aggregation scheme called RandomCrypt was proposed. RandomCrypt performed clipping and quantization to fix the range of gradient values and then added two types of noise on the gradient for encryption and differential privacy (DP) protection. It conducted HE on noise keys to revise the precision loss caused by DP protection. RandomCrypt was implemented based on a FATE framework, and a hacking simulation experiment was conducted. The results show that the proposed …

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Critical Node Identification Method For Unmanned Aerial Vehicle Cluster Considering Localized Features, Chenglong Shi, Xiang Hua, Dong Wang, Jinjin Zhang, Tianqi Jiang, Yuanzhang Dang Dec 2024

Critical Node Identification Method For Unmanned Aerial Vehicle Cluster Considering Localized Features, Chenglong Shi, Xiang Hua, Dong Wang, Jinjin Zhang, Tianqi Jiang, Yuanzhang Dang

Journal of System Simulation

Abstract: Aiming at the problem that the UAV cluster critical node identification methods focus on the global network and ignore the correlation between nodes and their local features, a critical nodes identification method for unmanned aerial vehicle cluster considering local features is proposed. An unmanned aerial vehicle cluster network model is constructed based on complex network theory. The Laplacian energy is introduced to evaluate the importance of node within two hops, and information entropy is combined to evaluate the importance of node in a specific motif to comprehensive identify the critical nodes. Simulation results demonstrate that this method identifies critical …

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Optimization Of Urban Agglomeration Transportation Network Evacuation Paths, Bowei He, Chengbing Li, Shida Nie, Jialin Wang Dec 2024

Optimization Of Urban Agglomeration Transportation Network Evacuation Paths, Bowei He, Chengbing Li, Shida Nie, Jialin Wang

Journal of System Simulation

Abstract: Given the complexity of the internal transportation network structure within urban agglomerations and the presence of numerous alternative routes, this paper proposes an enhanced ant colony algorithm to address the evacuation path problem of urban agglomeration transportation networks. A comprehensive urban agglomeration transportation network model is constructed, in which the issue of virtual transfer edges within the urban scope is considered and a weighting function is constructed taking into account the travelling time cost and the transferring time cost. Optimizations are applied to the ant colony algorithm, constructing an adaptive adjustment of state transitions and an information pheromone update …

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Scientifically Improving Human-Nature Relationship In Desertification Areas, Bojie Fu, Yanxu Liu, Shuai Wang, Junfeng Song, Zejiang Li Dec 2024

Scientifically Improving Human-Nature Relationship In Desertification Areas, Bojie Fu, Yanxu Liu, Shuai Wang, Junfeng Song, Zejiang Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

The expansion trend of desertification in China has been fundamentally restrained. In the new era, scientifically improving the relationship between human and nature in desertification areas to promote regional sustainable development has become an important demand for desertification combat in China. We summarize four key challenges to sustainable development in desertification areas, including increasing human demand on water, increasing land use intensity, increasing climatic risk, and insufficient industrial innovation. Based on the theoretical understanding of the coupling relationship between human and nature, the evolution of human-nature relationship in combating desertification can be divided into four stages, namely, extensive land exploitation, …

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Five Key Issues And Governance Strategies In Integration Of China’S National Computing Power, Tao Hong, Le Cheng Dec 2024

Five Key Issues And Governance Strategies In Integration Of China’S National Computing Power, Tao Hong, Le Cheng

Bulletin of Chinese Academy of Sciences (Chinese Version)

Computing power, as a core element of artificial intelligence, has not received sufficient research and attention compared to data and algorithms, and has become the short board of China in international artificial intelligence competition. In fact, the integrated construction of the arithmetic system is not only an inherent requirement for the development of the digital industry, but also a regular guide for the growth of the digital economy, and a core driver for the transformation of the digital society. Although it has always secured endorsement by national policy, the relevant legal norms and actual layout are still insufficient, and the …

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A Threat Assessment Method In Uncertain Dynamic Environments, Mei Yang, Bingkun Wang, Zhongjie Zhang, Yan Zeng, Jian Huang Dec 2024

A Threat Assessment Method In Uncertain Dynamic Environments, Mei Yang, Bingkun Wang, Zhongjie Zhang, Yan Zeng, Jian Huang

Journal of System Simulation

Abstract: A threat assessment method based on priori information and dynamic observation results is studied for the existence of dynamic uncertainty in complex war systems. The data mining is applied to obtain prior knowledge on the battlefield situation and construct an equipment-related confidence matrix. The sensor model is constructed to dynamically update the number of blue-side entities under the current situation by using the Bayesian method and considering both intelligence and observation results. The threat evaluation indicators and their weights are determined, and the TOPSIS method is used to finish the threat assessment. This method can well describe the complex …

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Research On Adaptive Scheduling Of Single-Arm Cluster Tools For Throughput Ratio Of Multiple Wafer Types With Concurrent Processing, Chunrong Pan, Yu Cui, Wenqing Xiong, Hao Zhou, Jiliang Luo Dec 2024

Research On Adaptive Scheduling Of Single-Arm Cluster Tools For Throughput Ratio Of Multiple Wafer Types With Concurrent Processing, Chunrong Pan, Yu Cui, Wenqing Xiong, Hao Zhou, Jiliang Luo

Journal of System Simulation

Abstract: Concurrent processing makes the wafer fabrication process prone to deadlocks and completion node ambiguity. A Petri net model is established to describe the system operation process by taking for the single-arm cluster tools for fully parallel processing of two wafer types as the research object, and a control strategy is developed to avoid the system deadlock. Based on the Petri net model, the temporal properties of the system is analyzed based on earliest starting strategy, and the action cycle sequence of robot is determined during the monitoring cycle for different scenarios of lot switching in a single production monitoring …

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Research On Latent Space-Based Anime Face Style Transfer And Editing Techniques, Haixin Deng, Fengquan Zhang, Nan Wang, Wancai Zhang, Jierui Lei Dec 2024

Research On Latent Space-Based Anime Face Style Transfer And Editing Techniques, Haixin Deng, Fengquan Zhang, Nan Wang, Wancai Zhang, Jierui Lei

Journal of System Simulation

Abstract: To address issues such as image distortion and style uniformity in existing anime style transfer networks within the field of image simulation, we propose the TGFE-TrebleStyleGAN (textguided facial editing with TrebleStyleGAN) for anime facial style transfer and editing. This framework leverages vector guidance within the latent space to generate facial imagery and incorporates a detail control module and a feature control module to constrain the aesthetic attributes of the generated images. The images generated by the transfer network serve as style control signals and constraints for fine-grained segmentation. Text-to-image generation technology captures correlations between styletransferred images and semantic information. …

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Research On Multi-Objective Gait Planning Of Biped Robot Based On Virtual Prototype, Yankai Zhang, Xuesong Wang, Yubin Jin, Dongsheng Zhang Dec 2024

Research On Multi-Objective Gait Planning Of Biped Robot Based On Virtual Prototype, Yankai Zhang, Xuesong Wang, Yubin Jin, Dongsheng Zhang

Journal of System Simulation

Abstract: A multi-objective gait optimization method based on virtual prototype is proposed to address the difficulty of balancing personalisation and performance in gait planning for bipedal robots. A scale prototype of a planar underactuated biped robot is created according to the body structure of Chinese people, and an identification approach is used to determine the robot's exact inertial parameters. A virtual prototype of the robot is created, and three optimization goals—speed, energy use, and stability are developed. Using the enhanced NSGA-II algorithm, the Pareto optimal solution set for the robot multi-objective gait planning issue is produced. Numerous gaits that conform …

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Intersection Braking Guidance For Trams Based On Lineside Signs, Wencong Tong, Jing Teng, Junxian Li, Xing Yao, Zhongjie Zhang Dec 2024

Intersection Braking Guidance For Trams Based On Lineside Signs, Wencong Tong, Jing Teng, Junxian Li, Xing Yao, Zhongjie Zhang

Journal of System Simulation

Abstract: Trams need to brake frequently due to signal control and safety speed limits at intersections. Due to the inaccuracy of distance judgment, tram drivers tend to reserve extra braking distance at intersections, resulting in lower braking coefficients and a decrease in speed. An intersection braking guidance method using lineside signs is proposed for trams to reduce braking distance redundancy and improve running speed. Drivers are guided to brake with the shortest possible distance by marking the initial braking position and speed of trams with fixed lineside signs. A tram driving simulation system was developed based on a vehicle dynamics …

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Interactions Of The Sars-Cov-2 Viral Genome 3’-Untranslated Region With Viral And Host Rnas, Caleb Frye, Mihaela Rita Mihailescu Dec 2024

Interactions Of The Sars-Cov-2 Viral Genome 3’-Untranslated Region With Viral And Host Rnas, Caleb Frye, Mihaela Rita Mihailescu

Electronic Theses and Dissertations

This dissertation focuses on the characterization of RNA-RNA interactions within the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome and with host microRNAs. As the causative agent of coronavirus disease 2019 (COVID-19), SARS-CoV-2 has evolved rapidly since its appearance. This has warranted prompt characterization of the virus particularly of its single stranded RNA (ssRNA) genome. By using a combination of bioinformatics, biophysics, and/or biological assays, we analyzed the SARS-CoV-2 viral genomic RNA and uncovered interactions of genomic RNA with host RNAs, highlighting an underutilized method of targeting RNA viruses. We showed here that the conserved elements in the viral genomic …

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Efficient Development Of Density-Insensitive Near-Infrared Methods For In-Line Drug Content Monitoring In Continuous Powder Streams, Natasha L. Velez-Silva Dec 2024

Efficient Development Of Density-Insensitive Near-Infrared Methods For In-Line Drug Content Monitoring In Continuous Powder Streams, Natasha L. Velez-Silva

Electronic Theses and Dissertations

A well-defined action plan to respond effectively to sudden changes in product demand is critical for preventing drug shortages within the pharmaceutical industry. An effective way to increase the output of a continuous manufacturing (CM) process is through flow rate adjustments. However, robust analytical methods must be in place to ensure consistent analytical performance across varying flow rates. Existing approaches for mitigating the physical effects of flow rate on Near-Infrared (NIR) measurements are often burdensome. Thus, efficient robust modeling strategies that reduce the current calibration burden and ensure model insensitivity to the physical variations in CM systems are needed. In …

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An Optimization Framework For Data Enrichment: A First Principles Approach To Designing Optimal Smoothers And Splines, Griffin Michael Kearney Dec 2024

An Optimization Framework For Data Enrichment: A First Principles Approach To Designing Optimal Smoothers And Splines, Griffin Michael Kearney

Dissertations - ALL

We develop a general framework for state estimation in systems modeled with stochastic dynamics and noisy measurements. Our approach is based on maximum likelihood estimation and employs a variety of techniques from optimization theory including the calculus of variations and discrete optimization to derive optimality conditions for many different types of problems. We make no rigid assumptions on the form of the mapping from measurements to state-estimate or on the distributions of the random processes, making the framework more general than existing techniques such as splines, Kalman smoothing or Gaussian Process Regressions, which are subject to limiting restrictions and modeling …

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Studies Towards The Synthesis Of A Simplified Forskolin Core And Phomactin A, Fortune Ononiwu Dec 2024

Studies Towards The Synthesis Of A Simplified Forskolin Core And Phomactin A, Fortune Ononiwu

Dissertations - ALL

Oxadecalins are privileged scaffolds found in various natural products that show biological activity, such as platelet aggregating factor antagonism and activation of adenyl cyclase. As such, various synthetic methods such as intramolecular substitution reactions and [4+2] cycloadditions have been developed for the construction of these important intermediates. Studies towards the synthesis of a simplified core of the labdane diterpene, forskolin, are described. Forskolin is the only known supplement to naturally raise cAMP levels, thereby displaying important pharmacological properties. The synthetic route described features a Lewis acid catalyzed dihydropyrone Diels-Alder reaction for rapidly assembly of the ABC tricycle. Modified Saegusa-Ito oxidation …

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On Physical Processes That Work Like Learning Algorithms, Vidyesh Rao Anisetti Dec 2024

On Physical Processes That Work Like Learning Algorithms, Vidyesh Rao Anisetti

Dissertations - ALL

Adaptive behavior is a widespread phenomenon observed in both living and non-living systems, manifesting in diverse forms such as the directional growth of plants in response to sunlight and the directed aging of materials. Such diversity demands a physics-based approach. Thus, the emerging field of physical learning aims to explain these phenomena by drawing analogies between adaptive processes in nature and learning in neural networks, motivating the central question of this thesis: Can physical processes in nature function like learning algorithms? A typical learning algorithm involves two fundamental steps: signaling and weight up- dating. In the Part I of the …

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Enhancing Graph Neural Networks By Editing Graphs, Jiayu Li Dec 2024

Enhancing Graph Neural Networks By Editing Graphs, Jiayu Li

Dissertations - ALL

Graphs are pervasive in both the natural world and various domains of science and engineering. Numerous advanced classifiers, such as Graph Neural Networks (GNNs), have been developed to perform node classification on these graphs. However, as graphs become denser with an increasing number of edges, GNNs often suffer from suboptimal generalization performance due to the presence of task-irrelevant connections. These redundant connections can introduce noise, consume excessive computational resources, and degrade performance. Identifying and preserving critical connections in large-scale graphs, while pruning unnecessary ones, is crucial for enhancing the efficiency and accuracy of GNNs in node classification, particularly for GCNs. …

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Peptides And Metalloproteins: Evolution, Catalysis And Material Design, Dona Imanga Upamadi Edirisinghe Dec 2024

Peptides And Metalloproteins: Evolution, Catalysis And Material Design, Dona Imanga Upamadi Edirisinghe

Dissertations - ALL

Peptide hydrogels are an important class of biomaterials that have gained significant attention in recent years. The stimuli responsive materials change their properties in response to pH, redox, temperature and enzymes and this property allowed us to design the materials with tunable properties based on their end application. This dissertation reports the de novo design, synthesis and characterization of short chain peptide sequences and optimizations of those in order to develop them into potential candidates in wound care and drug delivery applications. The investigation of these novel peptide sequences will open up new possibilities to tailor the properties through simple …

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Molten Flux Synthesis Of Plutonium (Iv) Silicates K2Pusi2O7 And Rb2Pusi6O15, Travis K. Deason, Gregory Morrison, Amir Mofrad, Jake Amoroso, David Diprete, Theodore M. Besmann, Shanna L. Estes, Hans Conrad Zur Loye Dec 2024

Molten Flux Synthesis Of Plutonium (Iv) Silicates K2Pusi2O7 And Rb2Pusi6O15, Travis K. Deason, Gregory Morrison, Amir Mofrad, Jake Amoroso, David Diprete, Theodore M. Besmann, Shanna L. Estes, Hans Conrad Zur Loye

Faculty Publications

Few plutonium containing silicates have been reported in the literature and only one other tetravalent plutonium silicate structure has been reported using the flux growth method. With the goal of understanding actinide incorporation into silicates, we describe herein two new plutonium (IV) silicates, Rb2PuSi6O15 and K2PuSi2O7, synthesized using a mixed alkali chloride/alkali fluoride flux growth. Both structures crystallize in the C2/c space group with lattice parameters a=24.2980(10) Å, b=7.1466(3) Å, c=17.2025(8) Å and 96.6560(10)° for Rb2PuSi6O15, and a=9.9478(2) Å, b=5.59820 (10) Å, c=13.1848(2) Å, and 105.7400(10)° for K2PuSi2O7. Comparisons to the synthesis of other reported alkali actinide silicates (Ce, U, …

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Re: Butte Mine Flooding Operable Unit Berkeley Pit And Discharge Pilot Project – November 2024 Monthly Discharge Monitoring Report, Mark Thompson, Dave Griffis Dec 2024

Re: Butte Mine Flooding Operable Unit Berkeley Pit And Discharge Pilot Project – November 2024 Monthly Discharge Monitoring Report, Mark Thompson, Dave Griffis

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

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Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Final Bpsou Insufficiently Reclaimed Sites Belle Of Butte (Bres No. 8 & Ur-39) Remedial Action Work Plan (Rawp) Request For Change Ir-2024-Ra-02 (Dated December 19, 2024), Molly Roby Dec 2024

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Final Bpsou Insufficiently Reclaimed Sites Belle Of Butte (Bres No. 8 & Ur-39) Remedial Action Work Plan (Rawp) Request For Change Ir-2024-Ra-02 (Dated December 19, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

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Mean From Median Estimation In Longitudinal Meta-Analysis Of Quality Of Life In Radiation Oncology Patients, Harlan R. Sayles Dec 2024

Mean From Median Estimation In Longitudinal Meta-Analysis Of Quality Of Life In Radiation Oncology Patients, Harlan R. Sayles

Theses & Dissertations

Meta-analysis of longitudinal data, where some of the studies report results with means and standard errors while others use medians and ranges, is a complex analytical problem with several challenges which must be overcome. Existing methods for estimating means from medians and either ranges, interquartile ranges, or both have not previously been evaluated in a longitudinal setting. In this work, a simulation study was used to estimate mean bias, between studies variance bias, and coverage of confidence intervals in a longitudinal setting. A second simulation study estimated the variance of meta-analysis results from a given set of studies that may …

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Assembly Of Ppsu-Oligomers, Mariam Nesterov Dec 2024

Assembly Of Ppsu-Oligomers, Mariam Nesterov

Student Theses and Dissertations

The development of nanostructures for delivering multiple proteins to targeted antibodies has become a promising avenue in biotechnology, driven by advancements in synthetic polymers like poly(propylene sulfone), PPSU. However, the PPSU polymer faces a major limitation - its high insolubility. To address this challenge, this study investigates whether PPSU oligomers can enhance both the solubility and stability of lysozyme, a model protein that is cost-effective and widely accessible. Using dimer, trimer, tetramer, and hexamer configurations, we analyzed the interactions between PPSU oligomer and lysozyme under varying conditions. Our results show that the dimer and trimer are water soluble (no aggregate …

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