Physical Sciences and Mathematics Commons^™

Clinical Subtypes Of Co-Morbid Insomnia And Obstructive Sleep Apnea (Comisa): Results Of A Cluster Analysis, Yuan Shi, Xujun Feng, Fengyi Hao, Yuru Nie, Yihui Zhang, Zhaohua Chen, Siqi Guan, Larry D. Sanford, Michael V. Vitiello, Xiangdong Tang

Department of Pathology & Anatomy Faculty Publications

Background

Variations in the bidirectional relationship between obstructive sleep apnea (OSA) and insomnia in co-morbid insomnia and OSA (COMISA) may form distinct subtypes of COMISA, which have not been previously characterized. This study aims to identify and characterize subtypes of COMISA.

Methods

From a community-recruited COMISA cohort 256 individuals who met diagnosis for COMISA were used to identify subtypes using a two-step clustering methodology. Demographics and multidimension clinical characteristics were collected and compared among obtained subtypes. Logistic models were used to evaluate whether these subtypes were associated with cardiometabolic and mental disorders. A clinical cohort of 1816 COMISA patients was …

Wearable Sensor-Based Phase Segmentation Analysis Of Front Crawl Swimming: A Scoping Review, Jonathan Simoes, Samuel Aylward, Daniel Hamze, Daniel James Goble, Daniel M. Russell, Joshua Haworth

Exercise Science Faculty Publications

Front crawl swimming stroke phase segmentation has historically relied on video analysis, but the development of wearable sensor technology has created new opportunities for automated phase segmentation. This scoping review mapped the available evidence on wearable sensor-based stroke phase segmentation methods in front crawl swimming, following PRISMA-ScR guidelines. A systematic search of SPORTDiscus, Web of Science, and IEEE Xplore conducted from January to June 2026, identified 15 eligible peer-reviewed studies published between 2000 and 2024. The review revealed an emerging field of research that has converged methodologically around inertial measurement units (IMUs) and the Chollet phase segmentation framework while remaining …

Assessing Forest Health And Small Mammals After A Limited Suppression Wildfire In Colville National Forest, Samantha J. Kennel

EWU Masters Thesis Collection

In the face of a wildfire crisis, there is a growing need to expand the pace and scale of forest treatments, including the strategic use of wildfire as a management tool. However, ecological outcomes remain uncertain in forests shaped by more than a century of fire suppression. The 2022 Thor Fire, a managed wildfire in the Colville National Forest, Washington, provides an opportunity to evaluate forest health in a relatively understudied system. Using a control–impact design, I established 100 monitoring plots in burned and adjacent unburned forests to assess how wildfire and fire severity influence forest structure, fuels, and tree …

Scope Of Microbial Transglutaminase For Site-Specific And Oriented Immobilization Of Native Antibodies From Various Host Species, Emily Beitello, Kwame Osei, Faith E. Breausche, Jon A. Friesen, Jeremy D. Driskell

Faculty Publications – Chemistry

Modification of antibodies to chemically couple labels or immobilization reagents is essential for developing biosensors. Typically, conjugation occurs through chemical methods that leverage reactive amines and thiols on native antibodies; however, this nonspecific approach can interfere with antibody function. Microbial transglutaminase (mTG) is an enzyme that has been used for site-specific conjugation of chemical modifiers to the F_c region of native antibodies, but thus far mTG-mediated conjugation has been limited to production of antibody-drug conjugates with human IgGs. Here, we assessed the scope and versatility of mTG to target IgGs, with the goal of site-specific conjugation to facilitate oriented …

Towards Novel Porphyrinoid Architectures: Synthesis Of Porphyrin Analogues With Two Six-Membered Exocyclic Rings, Amy L. Le, Timothy D. Lash

Faculty Publications – Chemistry

Tripyrranes with terminal ester protective groups were prepared by reacting 7-acetoxy-4,5,6,7-tetrahydroindoles with 3,4-diethylpyrrole in refluxing acetic acid-ethanol. Dibenzyl esters were deprotected by hydrogenolysis over 10% Pd/C and the resulting dicarboxylic acids were condensed with a series of dialdehydes in the presence of trifluoroacetic acid, followed by oxidation with FeCl₃ or DDQ, to give porphyrinoid products with two six-membered exocyclic rings. Reactions with a pyrrole dialdehyde gave porphyrins in 27-30% yield and good yields were also obtained using 2,5-furandicarbaldehyde and 4-hydroxy-2,6-pyridinedicarbaldehyde to prepare oxaporphyrins and oxypyriporphyrins. However, poorer results were noted for thiaporphyrins, benzocarbaporphyrins and oxybenziporphyrins due to their poor …

Amorphous Selenium Photodetectors For Liquid Noble Detectors, Michael Rooks

Physics Dissertations - Archive

Physics offers a way to connect deeply with the mysteries that surround us. Advances in detector physics, particularly in neutrino experiments and rare-event searches, have expanded our ability to probe phenomena that challenge how we describe the universe. Each discovery brings us closer to understanding the unknown, returning us to a sense of wonder that motivates exploration. My work on detector technology was inspired by a concept paper from Professor David Nygren, in which he noted the speculative possibility of integrating photon detection into a charge readout for pixelated liquid argon time projection chambers (LArTPCs) using the photoconductor amorphous selenium …

Tackling The Societal And Regulatory Challenges Of Emerging Technologies: A Case Study Of Deepfake, Jingyao Li

2026

Governing emerging technologies such as Artificial Intelligence (AI) poses enduring challenges for policymakers, industries, and societies. Early-stage governance is often hindered by limited understanding of technological implications, rapid innovation cycles, and resistance from powerful industry actors who favor minimal oversight. Yet, timely and effective governance is essential, as new technologies are most malleable in their formative stages. This dissertation examines how emerging technologies can be governed effectively by using deepfakes technology as a focal case. This dissertation comprises three interrelated studies.

The first paper reviews the literature on deepfakes and emerging technology governance, identifying the distinct characteristics of deepfake technology …

Do Developers Read Type Information? An Eye-Tracking Study On Typescript, Samuel W. Flint, Robert Dyer, Bonita Sharif

Research & Publications

Statically-annotated types have been shown to aid developers in a number of programming tasks, and this benefit holds true even when static type checking is not used. It is hypothesized that this is because developers use type annotations as in-code documentation. In this study, we aim to provide evidence that developers use type annotations as in-code documentation. Understanding this hypothesized use will help to understand how, and in what contexts, developers use type information; additionally, it may help to design better development tools and inform educational decisions. To provide this evidence, we conduct an eye tracking study with 26 undergraduate …

Neighborhood Embeddings And Scalable Learning For Optimal Transport And Unbalanced Optimal Transport, Muhammad S. Rana

Mathematics Dissertations - Archive

Dimensionality reduction techniques are developed from the assumption that high-dimensional data often arises from low-dimensional structures embedded into the high-dimensional ambient space. Classical dimensionality reduction methods rely on the Euclidean distance, which may fail to capture the geometric structures of the datasets. This dissertation includes alternative metrics for dimensionality reduction techniques and challenges in applying these techniques.

First, we investigate the Wasserstein distance based neighbor embeddings for dimensionality reduction methods and compare the classification and clustering performance with the classical Euclidean based methods. The Wasserstein distance models the data as probability distributions and compares two distributions applying optimal transport (OT) …

Investigating Netarts Bay, Oregon Coastal Landscape Change From Tectonic Subsidence Through Isotopic, Stratigraphic Records And Quantifying Dune Influence On Salt Marsh Morphodynamics, Emily Hall

Open Access Master's Theses

Coastal salt marshes on tectonically active margins face dual pressures from episodic seismic events and anthropogenic modifications. This study investigated how the 1700 CE Cascadia Subduction Zone earthquake and the 1900 CE introduction of invasive dune grass influenced back-barrier salt marsh morphodynamics at Netarts Bay, Oregon. It was hypothesized that (1) salt marsh habitats and elevation transitions would be detectable in geochemical proxies preserved in stratigraphy, (2) modern dune stabilization significantly limits mineral sediment delivery to the salt marsh, and (3) this reduction would be preserved in the stratigraphic record. Stratigraphic and isotopic analyses of sediment cores incorporating CT scans, …

Exploratory Investigation Of Greenhouse Gas Emissions In A Natural And Restored Salt Marsh, Sophia Motta

Open Access Master's Theses

Coastal wetlands are typically considered greenhouse sinks, specifically playing an important role in the global carbon cycle (Chmura et al., 2003), but new studies have pointed to anthropogenic interference leading to the understanding that altered tidal salt marshes may also be producers of methane to the atmosphere, contributing to the greenhouse effect. Hydrologic alteration including due to sea level rise (SLR), peat subsidence, impounded water, and decreased accretion rate disruption can have negative effects on marsh biochemistry leading to potential changes in electron acceptor availability, redox gradient shifts, and microbial community structure within the environment. This research is intended to …

Impact Of Water Quality And Gear Type On Eastern Oyster (Crassostrea Virginica) Growth In Narragansett Bay, Ri, Jacqueline Rosa

Open Access Master's Theses

Oyster aquaculture is expanding in Rhode Island, yet key farming regions in the lower West Passage of Narragansett Bay (WPNB) lack the in-situ, high-temporal resolution monitoring needed to evaluate emerging stressors and support production. At the same time, the industry is undergoing rapid technological development aimed at improving production while reducing labor and overall costs. In recent years, a low-maintenance, alternative surface gear was introduced in WPNB; however, its impact on oyster performance relative to traditional cultivation methods has not been quantified. This study established a 1.5-year continuous water quality time series in WPNB and paired these observations with …

Data Improved Models Applied To Essential Oceanographic Processes In Rhode Island Coastal Waters, Ainsley Fruhwirth

Open Access Master's Theses

The Ocean State Ocean Model (OSOM), funded and developed through the National Science Foundation’s (NSF) Established Program to Stimulate Competitive Research (EPSCoR), was designed to simulate the physical dynamics of Rhode Island’s estuaries and shelf waters. However, the model struggled to capture key features of summer circulation in Rhode Island Sound (RIS), most notably the westward flowing coastal current and vertical stratification profile found in May through September. Significant errors in modeled lateral and vertical density gradients indicated that the thermohaline structure, physical mixing parameters, and forcing inputs required comprehensive revision. Using historical datasets from the National Oceanic and Atmospheric …

Assessment Of Local Amplification Causes At Coastal Strong Motion Stations With Elevated Ground Motion Residuals From The 2024 Tewksbury, New Jersey Earthquake, Patrick Daniele

Open Access Master's Theses

Elevated ground motion amplitudes at individual stations are commonly observed in earthquake datasets, yet the physical causes of these residuals are often not explicitly identified. This study investigates two seismic monitoring stations in southeastern New York that recorded amplified motions during the 2024 Mw 4.8 Tewksbury, New Jersey earthquake. A consistent set of established geophysical methods -- including multichannel analysis of surface waves (MASW), passive ambient noise arrays (MAM), stochastic inversion, horizontal-to-vertical spectral ratio (HVSR) analysis, and directional spectral ratio techniques -- was applied to directly characterize site conditions and identify the mechanisms contributing to amplification.

Results show that elevated …

A Specification-Driven Framework For Self-Supervised Learning In Specialized Vision Domains, Mahmut S. Gokmen

Theses and Dissertations--Computer Science

Self-supervised learning (SSL) has emerged as a principled approach to visual representation learning that derives supervisory signal directly from unlabeled data, enabling foundation models to be trained at scale without manual annotation. Deployments in medical imaging and biometric recognition have demonstrated the potential of this paradigm, yet the assumptions that make SSL effective on natural image benchmarks fail systematically in specialized domains. Generic SSL pipelines encode a tacit assumption that the most informative correspondence is spatial proximity within a single acquisition. In specialized domains this assumption breaks at the level of the data-generating process: the signal that carries domain-specific information …

Understanding The Drivers Of Marine Sediment Diagenesis In Carbonate-Bearing Sediments, Alex Reis

Theses and Dissertations--Earth and Environmental Sciences

Marine sediments serve as an important geochemical record used to study how the Earth’s climate and oceans have changed throughout geologic time. As such, it is critical to understand how these sediments can be altered following deposition on the seafloor. This dissertation targeted two key geochemical archives, carbonate and pyrite, to link changing burial conditions with the resulting marine sediment chemistry. In particular, primary carbonate minerals record several indicators of past ocean chemistry, while pyrite preserves information related to the redox state of the sediment during deposition and burial. Additionally, secondary processes associated with changes in pore fluid chemistry and …

Use Of Stable Isotope Geochemistry To Determine The Paleoenvironment Of The Pond Creek Coal Bed, Pike County, Eastern Kentucky, Vivian A. Edwards

Theses and Dissertations--Earth and Environmental Sciences

Wetlands are both critical habitats and bellwethers of the health of the environment. Coal, being the remains of wetlands, offers the possibility of understanding the evolution of wetlands over large climatic shifts. The paleoenvironment of coals can be determined from palynology, petrology, and geochemistry. Stable isotope ratios within coal, including carbon (δ¹³C), nitrogen (δ¹⁵N), and sulfur (δ³⁴S), are established tools for paleoenvironmental reconstructions. These ratios can be correlated to flora, geochemistry, macerals, and bacterial activity. However, carbon, nitrogen, and sulfur have given conflicting results in some studies and their correlation to known variables is …

On Stripping And Antipodes In Motivic Steenrod Algebras, Joshua A. Peterson

Theses and Dissertations--Mathematics

We generalize the stripping process to the (mod 2) $\mathbb{C}$- and $\mathbb{R}$-motivic settings. Throughout, we include discussion on how the process changes and the difficulties moving to more general settings. We also introduce antipodes and consider what a potential $\mathbb{R}$-motivic analogue may look like. Finally, we elaborate on how the results may be used in future work to generalize a nilpotence result of Walker and Wood.

Extensions Between Modules Defined By Lattice Paths In The Preprojective Algebra, Chloe Napier

Theses and Dissertations--Mathematics

In 2001, Fomin and Zelevinsky introduced cluster algebras which appear as coordinate rings of many varieties. We study cluster algebras coming from Richardson varieties. Leclerc gives a cluster structure on Richardson varieties using the representation theory of preprojective algebras. While this construction is very algebraic, we take a more combinatorial approach. The main goal is to find a combinatorial description for when certain cluster variables are compatible, or equivalently when modules defined by lattice paths in the preprojective algebra have trivial extensions. We extend the known results from Geiss, Leclerc, and Schröer that answer this question in the case of …

A Character Theory For Loop Representations Of Symmetric Monoidal Bicategories, Jordan Sawdy

Theses and Dissertations--Mathematics

Character theory arises in many distinct fields of mathematics, but its many instantiations often share a few key features: they arise in contexts where one object is acted on or parametrized by another, and they are often computed via "trace-like" formulas. Focusing on these properties, we present a categorical formalism for constructing such characters. We first define a notion of "loop representation" for symmetric monoidal bicategories, then build a character for such representations via the canonical symmetric monoidal trace. We then show that this character defines a symmetric monoidal functor which satisfies commutativity properties with respect to both restriction- and …

Inverse Problems For The Radiative Transport Equation In Local And Non-Convex Geometries, Faith E. Hensley

Theses and Dissertations--Mathematics

Inverse problems for the radiative transport equation (RTE) arise in a wide range of imaging applications, including optical tomography and problems motivated by non-line-of-sight imaging. Classical reconstruction methods rely heavily on ballistic, or unscattered, photons and typically require full boundary access, leading to severe instability and limited applicability in geometrically constrained settings. This dissertation investigates inverse radiative transport problems with restricted boundary data and develops reconstruction techniques based on scattered photons. The central focus of this work is the analysis and isolation of the single-collision term in the collision expansion of solutions to the RTE. By exploiting its distinct analytical …

Combinatorial Models For Nonnegativity In Flag Varieties, Williem L. Rizer

Theses and Dissertations--Mathematics

The nonnegative Grassmannian admits a widely studied cell decomposition due to Alexander Postnikov, whose cells are indexed by positroids and modeled by several equivalent combinatorial objects. Subsequent work by authors including Lauren Williams, Suho Oh, and Carolina Benedetti has further developed the combinatorics and geometry of these structures. In this dissertation, we extend some of Postnikov’s combinatorial framework to the nonnegative flag variety. While cell decompositions in this setting were previously obtained, notably in work of Konstanze Rietsch, our focus is on providing new combinatorial models that make this structure more explicit and computationally tractable. We introduce flag positroid pipe …

The Interaction Between Additive And Multiplicative Structures In Arithmetic Settings, Ali Alsetri

Theses and Dissertations--Mathematics

The first part of this thesis is concerned with Goldbach-type problems. In recent years, there has been an interest in developing density versions of Goldbach-type results. Namely, given a relatively dense subset A of the primes, one may study representations of integers as sums of primes belonging to the subset A. These density Goldbach-type results have been facilitated by the development of new tools from additive combinatorics, in particular the Fourier-analytic transference principle due to Green. We apply the transference principle to obtain a variant of Vinogradov’s theorem involving subsets of primes confined to the residue class 1 (mod 3). …

Local Energy Decay For Non-Stationary Damped Wave Operators, Nicholas Dj Arsenault

Theses and Dissertations--Mathematics

This work establishes integrated local energy decay (ILED) estimates for the damped wave equation on certain non-stationary spacetimes. The main technical result is a high frequency estimate that holds in great generality, provided that null geodesics trapped in a compact region are sufficiently damped. This is combined with low- and medium-frequency estimates to establish full local energy decay. We conclude by providing a counterexample where the damping assumption fails and local energy decay does not hold.

Understanding Möbius Inversion As Composite Of Dual Pairs, Isaac B. Kochmaan

Theses and Dissertations--Mathematics

Möbius inversion is a well-studied computational tool in number theory and combinatorics, but it exhibits a pattern which may be familiar to those who study categorical traces. In 2016, Kate Ponto and Michael Shulman characterized duality and traces in the bicategory of profunctors for a particularly nice class of one-cells. We extend these results. Consequently, we construct, for a given poset, a profunctor whose Euler characteristic is the Möbius function of said poset. In light of this, we propose a categorical notion of Möbius inversion.

Exploring The Limitations Of Substrate Scope In Dimethylallyltryptophan Synthases, Evan T. Miller

Theses and Dissertations--Pharmacy

Natural products (NPs), are the largest source of bioactive compounds in Nature, and are essential to the treatment of human disease. Nearly 50% of drugs approved for use from 1981 to 2019 owe some aspect of their development to NPs, either in terms of their structure, pharmacophore, or mechanism of action. However, NPs are difficult to structurally optimize. Chemoenzymatic methods for NP derivatization have been increasingly seen as practical alternatives to traditional synthetic methods. Prenyltransferases (PTs) are involved in the primary and secondary metabolism of plants, bacteria, and fungi, and they are key enzymes in the biosynthesis of many clinically …

Using Camera-Based Unmarked Spatial Capture-Recapture Modeling To Estimate Reintroduced Elk (Cervus Canadensis) Population Parameters And Distribution In Southeastern Kentucky, Claire Marie Muia

Theses and Dissertations--Forestry and Natural Resources

Estimation of population parameters is important for wildlife management decisions. Elk reintroduced to southeastern Kentucky experienced early irruptive population growth and are currently monitored using a statewide harvest-based statistical population reconstruction model (SPR) across the Kentucky Elk Restoration Zone (KERZ). Because the SPR model is spatially coarse and difficult to scale to the smaller management units comprising the KERZ, we conducted a spatially explicit capture-recapture study using a clustered camera-trapping array deployed for 10 weeks from June–August 2024 to estimate elk population parameters within Management Unit 4. Due to a lack of resights of GPS-marked elk, population parameters were estimated …

Investigation Of Mercury Bioaccessibility In Subsistence Fishes From The Canadian Subarctic, Kiran Mateo Sharma Mr

Theses and Dissertations (Comprehensive)

Fish consumption is the primary pathway for human exposure to methylmercury (MeHg), a global contaminant of concern known to cause adverse health effects. Fort Albany First Nation, a remote Indigenous community in northern Ontario that relies on fish for both subsistence and cultural practices, has expressed concern regarding the safety of local fish consumption. Community members and leaders have communicated several priorities for scientific research that are the foundation of this thesis. Specifically, consumers of wild-caught fish have asked how traditional cooking methods may affect mercury concentrations in fish, and how mercury concentrations in little-studied organs, such as liver and …

Barycentric Subdivision And Hyperbolic Geometry, Hannah Elisabeth Steger

Dissertations and Theses

Barycentric subdivision of a triangle is the geometrical process of repeatedly subdividing a triangle by connecting the midpoints of the sides to the opposite vertices. The transformations which determine this subdivision form a group acting on the hyperbolic plane, action which we will show is topologically transitive. We find specific cases when the barycentric subdivision process leads to flat triangles (all vertices on the x-axis) and, on the contrary, situations when shapes are positioned on an orbit that is a circle, hence never becoming flat. We will also analyse this process when the starting triangle is already flat and we …

Supplementary Material For Experimental Constraints On Rock And Mineral Alteration By Magmatic Gas: Implications For Mars (Safari Et Al., In Review), Natalie Zimmermann

Geosciences Research Data

This file contains supplemental data for the JGR manuscript Experimental Constraints on Rock and Mineral Alteration by Magmatic Gas: Implications for Mars (Safari et al., in review). It includes SEM images and associated EDS spectra of altered targets and phase coatings produced in gas-rock alteration experiments.