Open Access. Powered by Scholars. Published by Universities.®

Physical Sciences and Mathematics Commons™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 5851 - 5880 of 291660

Full-Text Articles in Physical Sciences and Mathematics

Systematic Synthesis Of Crispr/Cas Applications For Enhancing Salt Tolerance In Crops: A Decade Of Progress And Challenges, Xindi Sun, Fusheng Wu, Zhuanzhuan Ma, Guohao Liang, Shumei Chen, Xutong Hu, Shugao Fan, Ying Zhao Feb 2026

Systematic Synthesis Of Crispr/Cas Applications For Enhancing Salt Tolerance In Crops: A Decade Of Progress And Challenges, Xindi Sun, Fusheng Wu, Zhuanzhuan Ma, Guohao Liang, Shumei Chen, Xutong Hu, Shugao Fan, Ying Zhao

School of Mathematical & Statistical Sciences Faculty Publications

Soil salinity is a major constraint on global crop productivity, driving the need for salt-tolerant varieties. While CRISPR-Cas genome editing offers targeted solutions for trait improvement, significant biological and technical bottlenecks limit its application in conferring salt stress resilience. This systematic summarizes findings from 83 peer-reviewed studies (2015–2024) employing CRISPR/Cas technologies to improve salt tolerance in five major crops (rice, wheat, maize, sorghum, barley). Our systematic review reveals that early single-gene edits achieved modest gains (30–50% Na⁺ exclusion) but often showed limited yield gains in field settings, potentially due to compensatory regulation and environmental variation. The literature suggests that multiplex …

Go to article

Charge Acceleration Without Radiation, Yakir Aharonov, D. Collins, S. Popescu Feb 2026

Charge Acceleration Without Radiation, Yakir Aharonov, D. Collins, S. Popescu

Mathematics, Physics, and Computer Science Faculty Articles and Research

The existence of electromagnetic radiation—radio waves, microwaves, light, X-rays, and so on—is one of the most important physical phenomena, and our ability to manipulate them is one of the most significant technological achievement of humankind. Underlying this ability is our understanding of how radiation is produced: Whenever an electric charge is accelerated, it radiates. Or, at least, this is how it has been hitherto universally thought. Here, we prove that quantum mechanically electric charges can be accelerated without radiating. The physical setup leading to this behavior is relatively simple (once one knows what to do), but its reasons are deep: …

Go to article

A Mechanistic Model Of The Wash Shuffle And Monte Carlo Exploration Of Its Impact On Card Shuffling In Texas Hold’Em, Michael A. Alexeev, Peter B. Chi Feb 2026

A Mechanistic Model Of The Wash Shuffle And Monte Carlo Exploration Of Its Impact On Card Shuffling In Texas Hold’Em, Michael A. Alexeev, Peter B. Chi

UNLV Gaming Research & Review Journal

In casino games using a standard deck of cards, a wash shuffle is sometimes performed prior to the rest of the card shuffling procedure. Unlike other methods of shuffling, the wash shuffle has not yet been well studied. To this end, we first develop a mechanistic model of the wash shuffle based on our observation of how cards tend to move when a wash shuffle is being performed. Then, we use this model to simulate the card shuffling procedure used in casino poker rooms, and explore the resulting impact on where the cards are dealt in the context of Texas …

Go to article

Who Lets Ai Take Over? Cross-National Variation In Willingness To Delegate Socially Important Roles To Artificial Intelligence, Ala Yankouskaya, Mohamed Basel Almourad, Magnus Liebherr, Fahad Beyahi, Guandong Xu, Raian Ali Feb 2026

Who Lets Ai Take Over? Cross-National Variation In Willingness To Delegate Socially Important Roles To Artificial Intelligence, Ala Yankouskaya, Mohamed Basel Almourad, Magnus Liebherr, Fahad Beyahi, Guandong Xu, Raian Ali

All Works

Delegating socially significant roles to artificial intelligence (AI) is an emerging reality, yet little is known about how publics evaluate this transfer of responsibility across contexts and countries. This study applied a structural model to a large cross-national dataset (30,994 individuals in 35 countries) to test how cognitive appraisals, affective dispositions, and contextual factors jointly shape willingness to delegate socially important roles of companionship, mental health advisor, doctor and teacher to children to AI. The results revealed a robust hierarchy of delegation preferences, with companionship most frequently entrusted to AI, followed by mental-health advisor, teacher, and doctor. Cognitive appraisals emerged …

Go to article

Effective Wordle Heuristics, Ronald I. Greenberg Feb 2026

Effective Wordle Heuristics, Ronald I. Greenberg

Computer Science: Faculty Publications and Other Works

While previous researchers have performed an exhaustive search to determine an optimal Wordle strategy, that computation is very time consuming and produced a strategy using words that are unfamiliar to most people. With Wordle solutions being gradually eliminated (with a new puzzle each day and no reuse), an improved strategy could be generated each day, but the computation time makes a daily exhaustive search impractical. This paper shows that simple heuristics allow for fast generation of effective strategies and that little is lost by guessing only words that are possible solution words rather than more obscure words.

Go to article

Emerging Threats In Ai: A Detailed Review Of Misuses And Risks Across Modern Ai Technologies, Niyat Seghid, Farkhund Iqbal, Khalifa Al-Room, Áine Macdermott Feb 2026

Emerging Threats In Ai: A Detailed Review Of Misuses And Risks Across Modern Ai Technologies, Niyat Seghid, Farkhund Iqbal, Khalifa Al-Room, Áine Macdermott

All Works

The swift evolution of artificial intelligence (AI) has enabled unprecedented capabilities across domains, while simultaneously introducing critical vulnerabilities that can be maliciously exploited or cause unintended harm. Although multiple initiatives aim to govern AI-related risks, a comprehensive and systematic understanding of how AI systems are actively misused in practice remains limited. This paper presents a systematic review of AI misuse across modern AI technologies. We analyze documented incidents, attack mechanisms, and emerging threat vectors, drawing from existing AI risk repositories, prior taxonomies, and empirical case reports. These sources are synthesized into a unified analytical framework that categorizes AI misuse across …

Go to article

The Future Of West African Cacao Farming, Kathryn Lesniewski Feb 2026

The Future Of West African Cacao Farming, Kathryn Lesniewski

CAFE Symposium 2026

This poster covers the detrimental impact climate change has had on the West African cacao farming industry. It also covers long and short term solutions to climate change, and how the global chocolate market has been impacted by climate change.

Go to article

Improving Ground Cover Crop Fractional Vegetation Mapping Via Causality-Based Deep Representation Learning, Atif Latif, Masoumeh Hashemi, Matt Yost, Somayeh Esmaeili, Xiaojun Qi Feb 2026

Improving Ground Cover Crop Fractional Vegetation Mapping Via Causality-Based Deep Representation Learning, Atif Latif, Masoumeh Hashemi, Matt Yost, Somayeh Esmaeili, Xiaojun Qi

Computer Science Student Research

Semantic segmentation and deep learning methods have rarely been applied to fractional vegetation cover (FVC) segmentation tasks due to the lack of publicly available datasets for training deep learning models. FVC is a key indicator for assessing vegetation distribution, crop density, and crop responses to water availability and fertilizer application, yet conventional field-based measurement methods are time consuming, costly, labor intensive, and may lack the accuracy required for critical applications such as drought stress evaluation and water productivity. In this paper, we introduced causality-based deep learning techniques for FVC segmentation on a publicly available RGB dataset that consists of four …

Go to article

An Autonomous Robotic System For Object Retrieval And Delivery: Enhancing Independence For Users Living With Disability And Older Adults, Jincheng Li, Chenghao Lin, Amna Mazen, Youssef A. Bazzi Feb 2026

An Autonomous Robotic System For Object Retrieval And Delivery: Enhancing Independence For Users Living With Disability And Older Adults, Jincheng Li, Chenghao Lin, Amna Mazen, Youssef A. Bazzi

Michigan Tech Publications

As the global population ages, there is a growing need for assistive technologies to help older adults maintain their independence. This work presents a cost-effective autonomous socially assistive robot designed for object retrieval and delivery, enhancing accessibility in home environments. The system is built on the Robot Operating System (ROS) framework and integrates three key components: the Pioneer P3-DX mobile robot for autonomous navigation, the ReactorX-200 robotic arm for pick-and-place operations, and the Kinect v2 RGB-D camera for object detection and localization. Users interact with the robot through natural language processing by issuing voice commands to retrieve various objects. Microsoft …

Go to article

Nonenzymatic Glucose Biosensor Based On Selective Reduction Of Silver Ions, Maryam Sarlak, Shankar B. Rananavare Feb 2026

Nonenzymatic Glucose Biosensor Based On Selective Reduction Of Silver Ions, Maryam Sarlak, Shankar B. Rananavare

Chemistry Faculty Publications and Presentations

A nonenzymatic conductivity-based glucose biosensor, reported here, designed for potential noninvasive measurement in accessible biofluids such as saliva, sweat, and tears. The sensor exploits a classic Tollens’ silvering process that deposits metallic silver on a sensitized surface via a quantitative, selective reduction of silver ions by glucose. Of the two surface sensitization methods used, the self-assembled bifunctional thiol/silane surfactant yields a more stable and sensitive sensor than tin(II) chloride. The conductometric sensor consists of two spiral interdigitated silver electrodes fabricated by lithography and wet etching. The sensor impedance changes after selective metallic silver deposition between the electrodes. The sensor exhibits …

Go to article

Final Repository Siting Study (Rss) Detailed Evaluation And Recommendations Report, Atlantic Richfield Company, Butte Silver Bow Feb 2026

Final Repository Siting Study (Rss) Detailed Evaluation And Recommendations Report, Atlantic Richfield Company, Butte Silver Bow

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Go to article

Final 2022 Unreclaimed Sites Sampling: Ur-28 Site Evaluation Summary Report, Pioneer Technical Services, Inc. Feb 2026

Final 2022 Unreclaimed Sites Sampling: Ur-28 Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Go to article

Exploring The Efficacy Of Storytelling In Education About Climate Change, Nina Adjanin, Srijana Katuwal, Heidi Sevestre, Gordon Brooks Feb 2026

Exploring The Efficacy Of Storytelling In Education About Climate Change, Nina Adjanin, Srijana Katuwal, Heidi Sevestre, Gordon Brooks

Mid-Western Educational Researcher

From bedtime tales to digital narratives, stories wield unparalleled influence, shaping perceptions, and fostering empathy. Through mediums like social media and digital platforms, storytelling becomes a tool for advocacy, amplifying voices, and catalyzing social change. In this qualitative study, 107 higher education students from diverse backgrounds participated. The purpose of this study was to uncover salient beliefs about climate change stories on popular social media platforms among full-time college students. The results are based on three key components of the theory of planned behavior (TPB): affective beliefs, normative beliefs, and control beliefs. The respondents expressed both positive and negative attitudes …

Go to article

News Briefs, Marvin H. Jeter Iii, Joyce Shaw Feb 2026

News Briefs, Marvin H. Jeter Iii, Joyce Shaw

Mississippi Libraries

News updates from Gunter Library at the Gulf Coast Research Laboratory and from the Mississippi Library Commission.

Go to article

Long-Range Fit: A Software Package For The Representation And Study Of Long-Range Molecular Interactions, Adrian L. Batista-Planas, Ernesto Quintas-Sánchez, Richard Dawes Feb 2026

Long-Range Fit: A Software Package For The Representation And Study Of Long-Range Molecular Interactions, Adrian L. Batista-Planas, Ernesto Quintas-Sánchez, Richard Dawes

Chemistry Faculty Research & Creative Works

Describing intermolecular forces is fundamental to modeling and predicting the behavior of molecular systems. In particular, long-range molecular interactions with electrostatic, induction, and dispersion as the main components play a critical role, especially for low-temperature and low-density regimes. Long-range interactions are often described through perturbation theory, representing the electronic charge distribution via a multipolar series of the moments and polarizability tensors corresponding to each molecule. However, while the theory is well established, obtaining the resulting analytical expressions (and their practical implementation) constitutes a highly complex and system-dependent task. To address this challenge, we developed long-range-fit (LRF), an interactive and user-friendly …

Go to article

Chemical Control Strategies For Poa Annua In Managed Turfgrass Systems, James D. Mccurdy, Rebecca G. Bowling, Aaron J. Patton, Edicarlos B. De Castro, James T. Brosnan, David E. Ervin, Shawn D. Askew, Clebson G. Goncalves, Matthew T. Elmore, J. Scott Mcelroy, Multiple Additional Authors Feb 2026

Chemical Control Strategies For Poa Annua In Managed Turfgrass Systems, James D. Mccurdy, Rebecca G. Bowling, Aaron J. Patton, Edicarlos B. De Castro, James T. Brosnan, David E. Ervin, Shawn D. Askew, Clebson G. Goncalves, Matthew T. Elmore, J. Scott Mcelroy, Multiple Additional Authors

Environmental Science and Management Faculty Publications and Presentations

Poa annua L. is a widespread and persistent weed in managed turfgrass systems, exhibiting both annual and short-lived perennial growth habits. Effective management requires an integrated approach, with chemical herbicides remaining a primary tool. This review outlines the current landscape of chemical control strategies, including pre-emergence and post-emergence herbicide options, plant growth regulators, and emerging chemistries. Herbicide resistance in Poa annua continues to pose a significant challenge, with confirmed cases spanning multiple modes of action. Consequently, sustainable management depends on rotating herbicide classes, using mixtures and sequences of treatments, and integrating nonchemical tactics.

Go to article

Hiding Behind A Curtain Of Dust: Gas And Dust Properties Of An Ultra-Luminous Strongly-Lensed Z = 3.75 Galaxy Behind The Milky Way Disc, Belén Alcalde Pampliega, Kevin C. Harrington, Aristeidis Amvrosiadis, Manuel Aravena, Min S. Yun, Hugo Messias, Antonio Hernán-Caballero, Leindert Boogaard, Axel Weiß, Benjamin Beauchesne, Alejandro Santamaría-Miranda, Monica Ivette Rodriguez, Eric Jiménez-Andrade, Manuel Solimano, James Lowenthal, Patrick Kamieneski, Q. Daniel Wang, Chentao Yang, Amit Vishwas, Pascale Hibon, Brenda Frye, Jorge González-Lopez, Yiqing Song, Meghana Killi Feb 2026

Hiding Behind A Curtain Of Dust: Gas And Dust Properties Of An Ultra-Luminous Strongly-Lensed Z = 3.75 Galaxy Behind The Milky Way Disc, Belén Alcalde Pampliega, Kevin C. Harrington, Aristeidis Amvrosiadis, Manuel Aravena, Min S. Yun, Hugo Messias, Antonio Hernán-Caballero, Leindert Boogaard, Axel Weiß, Benjamin Beauchesne, Alejandro Santamaría-Miranda, Monica Ivette Rodriguez, Eric Jiménez-Andrade, Manuel Solimano, James Lowenthal, Patrick Kamieneski, Q. Daniel Wang, Chentao Yang, Amit Vishwas, Pascale Hibon, Brenda Frye, Jorge González-Lopez, Yiqing Song, Meghana Killi

Astronomy: Faculty Publications

We present a detailed analysis of J154506, a strongly lensed submillimetre galaxy (SMG) behind the Lupus-I molecular cloud, and a characterisation of its physical properties using a combination of new and archival data, including VLT/MUSE and FORS2 optical data. We identify two high-significance (S/N >5) emission lines at 97.0 and 145.5 GHz, corresponding to CO(4-3) and CO(6-5), respectively, in spectral scans from the Atacama Compact Array (ACA) and the Large Millimetre Telescope (LMT), as well as the [CII] 158 µm fine-structure line at 400 GHz observed with the Atacama Pathfinder Experiment (APEX). These detections yield a spectroscopic redshift of …

Go to article

Ai Scribe Use In Residency Training: A Call For Specialty Society Guidance In Graduate Medical Education, Julia A. Giordano, Elizabeth Jones Feb 2026

Ai Scribe Use In Residency Training: A Call For Specialty Society Guidance In Graduate Medical Education, Julia A. Giordano, Elizabeth Jones

Department of Dermatology and Cutaneous Biology Faculty Papers

Artificial intelligence (AI) is increasingly used for documentation purposes in clinical practice, yet guidance for resident use is limited. Given the substantial documentation burden on medical trainees, AI-powered scribing tools may offer benefits, but their integration into residency training raises educational, supervisory, and patient safety considerations. This study aimed to assess the availability of resident-specific guidance on AI scribe use from major medical and specialty organizations and to summarize current evidence on AI scribes in residency. We reviewed five major medical and specialty society websites (AAD, AMA, ACGME, AAMC, ABMS) via website searches and direct emails and conducted a PubMed …

Go to article

Discovery Of Horsfieldia Macrothyrsa Bioactives With Cytotoxic Effects On Breast Cancer Cells Through In Vitro And Docking Analyses, Megawati Megawati, Akhmad Darmawan, Agus Budiawan Naro Putra, Kartika Dyah Palupi, Marissa Angelina, Ahmad Randy, Siska Andrina Kusumastuti, Faris Hermawan, Sumi Hudiyono Feb 2026

Discovery Of Horsfieldia Macrothyrsa Bioactives With Cytotoxic Effects On Breast Cancer Cells Through In Vitro And Docking Analyses, Megawati Megawati, Akhmad Darmawan, Agus Budiawan Naro Putra, Kartika Dyah Palupi, Marissa Angelina, Ahmad Randy, Siska Andrina Kusumastuti, Faris Hermawan, Sumi Hudiyono

Karbala International Journal of Modern Science

This study investigated the phytochemical constituents and biological activities of Horsfieldia macrothyrsa leaves to identify their bioactive compounds. Methanol extracts were fractionated using n-hexane and ethyl acetate, followed by silica gel column chromatography with a stepwise polarity gradient. From 100 g of powdered leaves, three major    compounds were successfully isolated from the ethyl acetate fraction: 1-(2,4,6-trihydroxyphenyl)dodecan-1-one (1), sesamin (2), and β-sitosterol (3). Their chemical structures were confirmed using UV, IR, LC–MS/MS, and NMR  spectroscopy. Biological activities of the fractions and isolates were evaluated through DPPH antioxidant assays, α-glucosidase inhibition for antidiabetic activity, MTT …

Go to article

Data Management Plans For Grant Proposals, Rubab Shahzad Feb 2026

Data Management Plans For Grant Proposals, Rubab Shahzad

Day Family Research Lab Workshop Series

Fundamentals of research data management and how to create effective Data Management Plans (DMPs) and Data Management Sharing Plans (DMSP)

Go to article

Exceptional Variety Of Baryte-Celestine-Series Speleothems In Lechuguilla Cave (New Mexico, Usa), Max Wisshak, Johannes Birkenstock, Andrea Schröder-Ritzrau, Norbert Frank, Hazel A. Barton, Harvey R. Duchene Feb 2026

Exceptional Variety Of Baryte-Celestine-Series Speleothems In Lechuguilla Cave (New Mexico, Usa), Max Wisshak, Johannes Birkenstock, Andrea Schröder-Ritzrau, Norbert Frank, Hazel A. Barton, Harvey R. Duchene

International Journal of Speleology

An inventory of speleothems primarily composed of the closely related sulfate minerals baryte (BaSO4) and celestine (SrSO4) in Lechuguilla Cave (New Mexico, USA) has revealed an extraordinary variety. This includes subaerial stalactites, stalagmites, flowstone, coralloids, wall crusts, floor crystals, snow, frostwork, and subaqueous pool crystals. Large baryte and celestine crystals have also been documented in hydrothermal veins in the host rock, predating the cave and truncated when intersected by it. The respective carbonate mineral phases witherite (BaCO3) and strontianite (SrCO3), in contrast, were found to be rare in the studied speleothem samples, …

Go to article

Cybersecurity In Higher Education Institutions: Awareness, Policy, And Experience On Employee Behaviour, Abdullahi Abiodun Yusuf, Adriana A. Steyn Feb 2026

Cybersecurity In Higher Education Institutions: Awareness, Policy, And Experience On Employee Behaviour, Abdullahi Abiodun Yusuf, Adriana A. Steyn

Journal of Cybersecurity Education, Research and Practice

The digital transformation of higher education institutions (HEIs) has introduced unprecedented connectivity and operational efficiency, but it has also heightened their exposure to cyber threats. South African HEIs, in particular, face increasing vulnerability due to their reliance on technology, openness, and diverse user communities. This study examines the influence of the institutional cybersecurity environment on employee cybersecurity-compliant behaviour (CCB), emphasising the critical roles of awareness, policy engagement, and experience. Drawing on Protection Motivation Theory and the Theory of Planned Behaviour, a conceptual model was developed to explore how cybersecurity awareness, policy familiarity, and prior experience shape employees’ attitudes, subjective norms, …

Go to article

Design And Functionalization Of A Hierarchical Cu-Btc/Zeolite A4 Composite With Tannic Acid For High-Performance Heavy Metal Removal: Synergistic Adsorption Mechanisms, Kinetic Insights, And Reusability Evaluation, Samar A. Salim Feb 2026

Design And Functionalization Of A Hierarchical Cu-Btc/Zeolite A4 Composite With Tannic Acid For High-Performance Heavy Metal Removal: Synergistic Adsorption Mechanisms, Kinetic Insights, And Reusability Evaluation, Samar A. Salim

Nanotechnology Research Centre

This study presents the development of a novel multifunctional adsorbent Cu-BTC (HKUST-1)/Zeolite A4 composite functionalized with tannic acid—for the efficient removal of toxic heavy metal ions (Pb²⁺, Cd²⁺, Cr(VI)) from aqueous solutions. The composite was synthesized via a solvothermal process and systematically characterized by XRD, FTIR, SEM-EDS, and BET surface area analysis. The resulting material exhibited a high specific surface area (1050 m²/g), a hierarchical pore structure, and a homogeneous distribution of active sites. Batch adsorption experiments revealed superior adsorption capacities of 220 mg/g for Pb²⁺, 180 mg/g for Cd²⁺, and 150 mg/g for Cr(VI) at pH 6, surpassing those …

Go to article

How Principals Who Use Artificial Intelligence For Innovation Create Cognitive Equity While Principals Who Use Ai For Efficiency Create Cognitive Debt, Jethro Jones Feb 2026

How Principals Who Use Artificial Intelligence For Innovation Create Cognitive Equity While Principals Who Use Ai For Efficiency Create Cognitive Debt, Jethro Jones

Dissertations

This dissertation in practice examined whether a targeted professional learning   intervention could shift school leaders’ use of generative artificial intelligence (AI) from efficiency-oriented tasks toward innovation-oriented strategic problem solving. AI is typically adopted to accelerate existing routines, which can deepen “cognitive debt” by reinforcing ineffective practices rather than improving systems. This study advanced a “cognitive equity” frame, positioning AI as a tool that can expand principals’ cognitive capacity to address complex problems and lead adaptive change. Using a quasi-experimental, single-group design, the study evaluated a free, full-day AI for Innovation workshop, which emphasized foundational understanding of how AI tools work …

Go to article

A Theoretical Investigation Of The Linear And Nonlinear Optical Responses Of Scandium- And Yttrium-Doped (Sub-Nm) Ag And Au Clusters, Munish Sharma, Mukesh Jakhar, Ravindra Pandey, Shashi P. Karna Feb 2026

A Theoretical Investigation Of The Linear And Nonlinear Optical Responses Of Scandium- And Yttrium-Doped (Sub-Nm) Ag And Au Clusters, Munish Sharma, Mukesh Jakhar, Ravindra Pandey, Shashi P. Karna

Michigan Tech Publications

We investigate the linear and nonlinear optical properties of (sub-nm) Ag6 and Au6 clusters doped with Sc and Y using time-dependent density functional theory. Both parent clusters have D3h ground-state geometries but exhibit noticeably different electronic structures; scalar-relativistic corrections in Au6 induce significant s-d hybridization, resulting in larger HOMO-LUMO gaps and reduced one-photon absorption (OPA) cross-sections compared to Ag6. Two-photon absorption (TPA) peaks in the UV region show resonance enhancement via coupling with OPA-active states, with Ag6 having larger cross-sections than Au6. Doping with Sc and Y modifies the optical responses by breaking configurational symmetry and lifting HOMO degeneracies. ScAg5 …

Go to article

Lake Powell And Lake Mead Are Moving In Opposite Directions -- What Gives?, Jack Schmidt, Eric Kuhn, Anne Castle, Kathryn Sorensen, Katherine Tara Feb 2026

Lake Powell And Lake Mead Are Moving In Opposite Directions -- What Gives?, Jack Schmidt, Eric Kuhn, Anne Castle, Kathryn Sorensen, Katherine Tara

The Traveling Wilburys of the Colorado River

No abstract provided.

Go to article

Monthly Progress Report Butte Priority Soils Operable Unit Consent Decree Partial Remedial Design/Remedial Action And Operation And Maintenance January 2026, Josh Bryson Feb 2026

Monthly Progress Report Butte Priority Soils Operable Unit Consent Decree Partial Remedial Design/Remedial Action And Operation And Maintenance January 2026, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Go to article

The Structure, Pathogenesis, And Inhibition Of The P53-Mdm2 Pathway, Amanda L. Brown, Xiaoying Lian, Qian Wang Feb 2026

The Structure, Pathogenesis, And Inhibition Of The P53-Mdm2 Pathway, Amanda L. Brown, Xiaoying Lian, Qian Wang

Faculty Publications

The p53 tumor suppressor protein plays a central role in maintaining genomic stability by regulating cell cycle arrest, apoptosis, and DNA repair under cellular stress. Mouse double minute 2 (MDM2), an E3 ubiquitin ligase, negatively regulates p53 via direct binding and proteasomal degradation. Overexpression or amplification of MDM2 can disrupt this pathway and promote tumorigenesis, even in cancers with wild-type p53. This review outlines the structural features of MDM2, particularly its N-terminal hydrophobic pocket and C-terminal RING domain, and their roles in p53 regulation. We further examine the pathological effects of MDM2 dysregulation and SNPs linked to increased cancer risk. …

Go to article

Project Risk Management In Ai-Enabled Systems: Managing Ethical, Privacy, And Governance Risks, Onome Cynthia Anakanire Feb 2026

Project Risk Management In Ai-Enabled Systems: Managing Ethical, Privacy, And Governance Risks, Onome Cynthia Anakanire

Harrisburg University Dissertations and Theses

This research examined how Artificial intelligence (AI) has been embedded in project-based work, particularly in finance and software industries, where it enables efficiency and assists in complex decision-making. However, these innovations introduce significant ethical, privacy, and governance risks that traditional project risk management frameworks fail to adequately address. This study investigated how project managers can systematically integrate the management of these emerging risks into AI-enabled projects. Using a qualitative research design, the study drew on semi-structured interviews with project managers, compliance officers, and AI developers in finance, software and related sectors. Supplementary data included internal project documentation and risk registers. …

Go to article

Selective Reversal Of Cu-Amyloid Aggregation Monitored In Real Time By Fluorescence Anisotropy: Ni-Bme-Dach Vs Edta Benchmarks, Alyssa N. Schroeder, Eleanor K. Adams, Dane C. Frost, Erica Lopez, Jennie R. Giacomini, Marilyn R. Mackiewicz Feb 2026

Selective Reversal Of Cu-Amyloid Aggregation Monitored In Real Time By Fluorescence Anisotropy: Ni-Bme-Dach Vs Edta Benchmarks, Alyssa N. Schroeder, Eleanor K. Adams, Dane C. Frost, Erica Lopez, Jennie R. Giacomini, Marilyn R. Mackiewicz

Chemistry Faculty Publications and Presentations

Metal dyshomeostasis, particularly involving Cu2+, is increasingly recognized as a key contributor to amyloid-β (Aβ) aggregation and neurotoxicity in Alzheimer’s disease, motivating the development of chelators capable of selectively disrupting pathogenic metal-Aβ interactions without perturbing essential biological metals. Here, we employ steady-state fluorescence anisotropy as a real-time probe of TAMRA-Aβ1–42 rotational mobility to quantify metal-induced aggregation and its reversibility by two chelators with distinct selectivities: EDTA, a broad-spectrum benchmark, and Ni-bme-dach, a sulfur-rich metallodithiolate with high Cu affinity. Cu2+ induces the most significant increases in anisotropy, consistent with rapid formation of large nanoscale aggregates, while Fe3+ produces moderate aggregation and …

Go to article

First Prev Next Last