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Full-Text Articles in Physical Sciences and Mathematics

Jackknife Empirical Likelihood Tests For Equality Of Generalized Lorenz Curves, Anton Butenko May 2023

Jackknife Empirical Likelihood Tests For Equality Of Generalized Lorenz Curves, Anton Butenko

Electronic Theses, Projects, and Dissertations

A Lorenz curve is a graphical representation of the distribution of income or wealth within a population. The generalized Lorenz curve can be created by scaling the values on the vertical axis of a Lorenz curve by the average output of the distribution. In this thesis, we propose two nonparametric methods for testing the equality of two generalized Lorenz curves. Both methods are based on empirical likelihood and utilize a U -statistic. We derive the limiting distribution of the likelihood ratio, which is shown to follow a chi-squared distribution with one degree of freedom. We conduct simulations to compare the …


Knot Equivalence, Jacob Trubey May 2023

Knot Equivalence, Jacob Trubey

Electronic Theses, Projects, and Dissertations

A knot is a closed curve in R3. Alternatively, we say that a knot is an embedding f : S1 → R3 of a circle into R3. Analogously, one can think of a knot as a segment of string in a three-dimensional space that has been knotted together in some way, with the ends of the string then joined together to form a knotted loop. A link is a collection of knots that have been linked together.

An important question in the mathematical study of knot theory is that of how we can tell when two knots are, or are …


Distance Correlation Based Feature Selection In Random Forest, Jose Munoz-Lopez May 2023

Distance Correlation Based Feature Selection In Random Forest, Jose Munoz-Lopez

Electronic Theses, Projects, and Dissertations

The Pearson correlation coefficient is a commonly used measure of correlation, but it has limitations as it only measures the linear relationship between two numerical variables. In 2007, Szekely et al. introduced the distance correlation, which measures all types of dependencies between random vectors X and Y in arbitrary dimensions, not just the linear ones. In this thesis, we propose a filter method that utilizes distance correlation as a criterion for feature selection in Random Forest regression. We conduct extensive simulation studies to evaluate its performance compared to existing methods under various data settings, in terms of the prediction mean …


Reverse Mathematics Of Ramsey's Theorem, Nikolay Maslov May 2023

Reverse Mathematics Of Ramsey's Theorem, Nikolay Maslov

Electronic Theses, Projects, and Dissertations

Reverse mathematics aims to determine which set theoretic axioms are necessary to prove the theorems outside of the set theory. Since the 1970’s, there has been an interest in applying reverse mathematics to study combinatorial principles like Ramsey’s theorem to analyze its strength and relation to other theorems. Ramsey’s theorem for pairs states that for any infinite complete graph with a finite coloring on edges, there is an infinite subset of nodes all of whose edges share one color. In this thesis, we introduce the fundamental terminology and techniques for reverse mathematics, and demonstrate their use in proving Kőnig's lemma …


Late Holocene Slip History Of The Central Garlock Fault, Mojave Desert, California, James Eric Burns May 2023

Late Holocene Slip History Of The Central Garlock Fault, Mojave Desert, California, James Eric Burns

Electronic Theses, Projects, and Dissertations

This study investigates the late Holocene slip history of the central Garlock Fault, using measurements of left-lateral offsets of alluvial features from airborne and hand-held LiDAR imagery, drone photogrammetry, and field measurements. IRSL dating of the offset late Holocene alluvial deposits was compared to published paleoseismic records to estimate the number of earthquakes that contributed to the offsets. Focus was given to geomorphic features offset in the past 1-4 earthquakes. Results indicate the average slip per earthquake was about 5.75 m (range: 4.75 to 6.25 m) in the past four events in the El Paso Mountains (EPM) and was 4.3-7.3 …


Determinants Of Cloud Computing Integration And Its Impact On Sustainable Performance In Smes: An Empirical Investigation Using The Sem-Ann Approach, Mohammed A. Al-Sharafi, Mohammad Iranmanesh, Mostafa Al-Emran, Ahmed I. Alzahrani, Fadi Herzallah, Norziana Jamil May 2023

Determinants Of Cloud Computing Integration And Its Impact On Sustainable Performance In Smes: An Empirical Investigation Using The Sem-Ann Approach, Mohammed A. Al-Sharafi, Mohammad Iranmanesh, Mostafa Al-Emran, Ahmed I. Alzahrani, Fadi Herzallah, Norziana Jamil

Research outputs 2022 to 2026

Although extant literature has thoroughly investigated the incorporation of cloud computing services, examining their influence on sustainable performance, particularly at the organizational level, is insufficient. Consequently, the present research aims to assess the factors that impact the integration of cloud computing within small and medium-sized enterprises (SMEs) and its subsequent effects on environmental, financial, and social performance. The data were collected from 415 SMEs and were analyzed using a hybrid SEM-ANN approach. PLS-SEM results indicate that relative advantage, complexity, compatibility, top management support, cost reduction, and government support significantly affect cloud computing integration. This study also empirically demonstrated that SMEs …


Low-Complexity Three-Dimensional Aoa-Cross Geometric Center Localization Methods Via Multi-Uav Network, Baihua Shi, Yifan Li, Guilu Wu, Riqing Chen, Shihao Yan, Feng Shu May 2023

Low-Complexity Three-Dimensional Aoa-Cross Geometric Center Localization Methods Via Multi-Uav Network, Baihua Shi, Yifan Li, Guilu Wu, Riqing Chen, Shihao Yan, Feng Shu

Research outputs 2022 to 2026

The angle of arrival (AOA) is widely used to locate a wireless signal emitter in unmanned aerial vehicle (UAV) localization. Compared with received signal strength (RSS) and time of arrival (TOA), AOA has higher accuracy and is not sensitive to the time synchronization of the distributed sensors. However, there are few works focusing on three-dimensional (3-D) scenarios. Furthermore, although the maximum likelihood estimator (MLE) has a relatively high performance, its computational complexity is ultra-high. Therefore, it is hard to employ it in practical applications. This paper proposed two center of inscribed sphere-based methods for 3-D AOA positioning via multiple UAVs. …


Artificial: A Study On The Use Of Artificial Intelligence In Art, Hayden Ernst May 2023

Artificial: A Study On The Use Of Artificial Intelligence In Art, Hayden Ernst

Theses/Capstones/Creative Projects

In the past three to five years there have been significant improvements made in AI due to improvements in computing capacity, the collection and use of big data, and an increase in public interest and funding for research. Programs such as ChatGPT, DALL•E, and Midjourney have also gained tremendous popularity in a relatively short amount of time. This led me to this project in which I aimed to gain a deeper understanding of these art generator AI and where they fit into art as a whole. My goal was to give recommendations to museums and exhibits in Omaha on what …


Applications Of High-Precision U-Pb Geochronology: Innovations And Insights Into Super-Eruption Petrochronology, Chronostratigraphy, And Linking Large Igneous Provinces, Michael T. Mohr May 2023

Applications Of High-Precision U-Pb Geochronology: Innovations And Insights Into Super-Eruption Petrochronology, Chronostratigraphy, And Linking Large Igneous Provinces, Michael T. Mohr

Boise State University Theses and Dissertations

The perpetual and persistent forward march of time is a geoscientist’s reference frame for understanding Earth’s natural changes that manifest in all scales of natural materials (e.g., minerals, fossils, glaciers, rocks, mountain belts, cratons). While indicators of relative timing can be abundant in natural materials (e.g., stratigraphic superposition, cross-cutting relationships, crystal growth zonation), numerical timing constraints are required to contextualize and constrain the ordering, duration, and rate of Earth system processes. For investigating Earth processes in deep time, radioisotopic ages provide a temporal foundation for deciphering the clues from an often fragmented and incomplete rock record. Among the radioisotope chronometers, …


Hydrologic Implications Of Snow-Vegetation Interactions In A Semiarid Mountain Climate, Maggi Kraft May 2023

Hydrologic Implications Of Snow-Vegetation Interactions In A Semiarid Mountain Climate, Maggi Kraft

Boise State University Theses and Dissertations

Knowledge of the complex interaction between snow, vegetation, and streamflow in semiarid mountain climates is necessary for predicting water resources. The effects of warming temperatures on snow distribution will cascade into vegetation water use and streamflow. Due to our reliance on snow water resources, it is necessary to understand how vegetation affects snow distribution, how vegetation uses snow water inputs and the subsequent effects on streamflow in the current and warming climate. The overall objective of this research is to improve our understanding of snow-vegetation interactions in a semiarid climate. In this dissertation, I use field data to evaluate how …


Application Of A High-Resolution Climate Model Dataset To Assess Habitat Suitability For Spotted Wing Drosophila In Southwest Idaho, Elizabeth Padian May 2023

Application Of A High-Resolution Climate Model Dataset To Assess Habitat Suitability For Spotted Wing Drosophila In Southwest Idaho, Elizabeth Padian

Boise State University Theses and Dissertations

As global climate change continues to produce large deviations from the normals of the 19th and 20th centuries, the agricultural sector will need to adapt to these changes in order to maintain yields and feed the global population. Crop selections, yield amounts, and pest management techniques may need to be adjusted to adapt. The Spotted Wing Drosophila (SWD) is a small fruit fly-like bug that can infest berries and stone fruit crops by burrowing into the fruit (at most points in the fruit’s lifecycle) and laying its eggs. These eggs will hatch and the larvae will burrow back out of …


Investigating The Petrogenesis Of The Naifeh And Plumeria Seamounts: Insights Into The Geochemical Diversity Of Seamounts Adjacent To The Hawaiian Seamount Chain, Geoffrey Montour May 2023

Investigating The Petrogenesis Of The Naifeh And Plumeria Seamounts: Insights Into The Geochemical Diversity Of Seamounts Adjacent To The Hawaiian Seamount Chain, Geoffrey Montour

Boise State University Theses and Dissertations

The Naifeh and Plumeria seamount clusters, which consist of 10 submarine volcanoes located ~220km north of the Northwest Hawaiian Ridge, were mapped and sampled by the E/V Nautilus expedition NA101 in 2018. The origin of these seamounts is unknown, but their unique orientation and location imply several possible mechanisms of formation. Four possible mechanisms of formation include: 1) off-axis upwelling of the Hawaiian mantle plume, 2) ancient arch volcanism, 3) intraplate extension and deformation, 4) hotspot volcanism. Investigating the origin of these seamount clusters will better constrain the composition of the underlying mantle, as well as the depth and extent …


Baseball’S Evolution In The 21st Century, And How It Exemplifies Human Response To Change, Jonathan Sharpe May 2023

Baseball’S Evolution In The 21st Century, And How It Exemplifies Human Response To Change, Jonathan Sharpe

Honors Projects

The game of baseball has changed a lot in the past twenty years. It can be primarily attributed to the explosion in data analytics and how they are used to evaluate baseball players. This led to different player profiles being preferred and eventually led to the development of players changing. As a result, the strategies employed have also evolved and turned into a different game than seen only a couple of decades ago. This paper will explore the changes that the game has seen. On the other hand, Major League Baseball has also implemented its own changes to try and …


What Does The Geometry Of The Hβblr Depend On?, Lizvette Villafaña, Peter R. Williams, Tommaso Treu, Brendon J. Brewer, Aaron J. Barth, Vivian U, Vardha N. Bennert, Hengxiao Guo, Misty C. Bentz, Gabriela Canalizo, Alexei V. Filippenko, Elinor Gates, Michael D. Joner, Matthew A. Malkan, Jong-Hak Woo, Bela Abolfathi, Thomas Bohn, K. Azalee Bostroem, Goni Halevi, Carol E. Hood, J. Chuck Horst, Maxime De Kouchkovsky, Benjamin Kuhn, Douglas C. Leonard, Raúl Michel, Melanie Kae B. Olaes, Daeseong Park, Jordan N. Runco, Remington O. Sexton, Isaac Shivvers, Chance L. Spencer, Benjamin E. Stahl, Samantha Stegman, Jonelle L. Walsh, Weikang Zheng May 2023

What Does The Geometry Of The Hβblr Depend On?, Lizvette Villafaña, Peter R. Williams, Tommaso Treu, Brendon J. Brewer, Aaron J. Barth, Vivian U, Vardha N. Bennert, Hengxiao Guo, Misty C. Bentz, Gabriela Canalizo, Alexei V. Filippenko, Elinor Gates, Michael D. Joner, Matthew A. Malkan, Jong-Hak Woo, Bela Abolfathi, Thomas Bohn, K. Azalee Bostroem, Goni Halevi, Carol E. Hood, J. Chuck Horst, Maxime De Kouchkovsky, Benjamin Kuhn, Douglas C. Leonard, Raúl Michel, Melanie Kae B. Olaes, Daeseong Park, Jordan N. Runco, Remington O. Sexton, Isaac Shivvers, Chance L. Spencer, Benjamin E. Stahl, Samantha Stegman, Jonelle L. Walsh, Weikang Zheng

Physics

We combine our dynamical modeling black-hole mass measurements from the Lick AGN Monitoring Project 2016 sample with measured cross-correlation time lags and line widths to recover individual scale factors, f, used in traditional reverberation-mapping analyses. We extend our sample by including prior results from Code for AGN Reverberation and Modeling of Emission Lines (CARAMEL) studies that have utilized our methods. Aiming to improve the precision of black-hole mass estimates, as well as uncover any regularities in the behavior of the broad-line region (BLR), we search for correlations between f and other AGN/BLR parameters. We find (i) evidence for a …


Joint Constraints On Kepler-36 From Kepler And New Keck-Hires Data, Nicholas Juliano May 2023

Joint Constraints On Kepler-36 From Kepler And New Keck-Hires Data, Nicholas Juliano

UNLV Theses, Dissertations, Professional Papers, and Capstones

I analyze new HIRES Radial Velocity (RV) data in conjunction with transit mid-times and uncertainties from the full 17 quarters of Kepler data to reassess the orbital parameters of the Kepler-36 system. Six additional RV measurements were taken by the Keck-HIRES spectrograph from September 21, 2021 to October 11, 2021. I carry out a differential evolution Markov Chain Monte Carlo-based (DEMCMC) analysis to infer improved orbital elements for the two known planets in the system. Leveraging additional information provided by the new RV measurements, I extend this DEMCMC analysis to a possible three-planet configuration. I explore the likelihood of a …


Analysis And Implementation Of A New High-Buck Dc-Dc Converter With Interleaved Output Inductors And Soft Switching Capability, Sajad Ghabeli Sani, Mohamad Reza Banaei, Seyed Hossein Hosseini May 2023

Analysis And Implementation Of A New High-Buck Dc-Dc Converter With Interleaved Output Inductors And Soft Switching Capability, Sajad Ghabeli Sani, Mohamad Reza Banaei, Seyed Hossein Hosseini

Turkish Journal of Electrical Engineering and Computer Sciences

This paper proposes an innovative structure for DC-DC converters with high buck gain by using a lower number of elements. The converter provides highly efficient output power and an extended output voltage range. In addition, the distribution of output current between two inductors and the soft-switching capability of the power switches have made the converter suitable for applications that require high output current. All power switches accomplish the ZVZCS (zero-voltage and zero-current switching) condition with the aid of a small auxiliary inductor (Lx), which charges and discharges parallel capacitors of main switches to provide soft-switching conditions. Thus, the switching losses …


An Efficient Deep Learning Architecture For Turkish Lira Recognition And Counterfeit Detection, Burak İyi̇kesi̇ci̇, Ergun Erçelebi̇ May 2023

An Efficient Deep Learning Architecture For Turkish Lira Recognition And Counterfeit Detection, Burak İyi̇kesi̇ci̇, Ergun Erçelebi̇

Turkish Journal of Electrical Engineering and Computer Sciences

Banknote counterfeiting is a common practice worldwide. Due to the recent developments in technology, banknote imitation has become easier than before. There are different kinds of algorithms developed for the detection of counterfeit banknotes for different countries in the literature. The earlier algorithms utilized classical image processing techniques where the implementations of machine learning and deep learning algorithms appeared with the developments in the artificial intelligence field as well as the computer hardware. In this study, a novel convolutional neural networks-based deep learning algorithm has been developed that detects counterfeit Turkish Lira banknotes and their denominations using the banknote images …


Understanding The Operations And Decision-Making Of Cow-Calf Farmers In Northwest Arkansas, Clayton Weyl May 2023

Understanding The Operations And Decision-Making Of Cow-Calf Farmers In Northwest Arkansas, Clayton Weyl

Agricultural Economics and Agribusiness Undergraduate Honors Theses

Societal pressure on farmers has become a more central part of the rhetoric surrounding livestock production. This study includes farmers in the discourse on the rhetoric surrounding climate change via interviews and simulations tailored to their operation. Previous research has addressed regenerative agricultural practices and conditions that influence farmer decision-making, but little research has analyzed decision-making in tandem with environmental practices. The literature reveals that cow-calf producer decision-making is influenced by their reliance on cattle as an income source, and farmers overall choose climate-friendly practices based on their perceptions about climate change. The goal of this research was to gather …


Tdcosmo - Xii. Improved Hubble Constant Measurement From Lensing Time Delays Using Spatially Resolved Stellar Kinematics Of The Lens Galaxy, Anowar J. Shajib, Pritom Mozumdar, Geoff C.-F. Chen, Tommaso Treu, Michele Cappellari, Shawn Knabel, Sherry H. Suyu, Vardha N. Bennert, Joshua A. Frieman, Dominique Sluse, Simon Birrer, Frederic Courbin, Christopher D. Fassnacht, Lizvette Villafaña, Peter R. Williams May 2023

Tdcosmo - Xii. Improved Hubble Constant Measurement From Lensing Time Delays Using Spatially Resolved Stellar Kinematics Of The Lens Galaxy, Anowar J. Shajib, Pritom Mozumdar, Geoff C.-F. Chen, Tommaso Treu, Michele Cappellari, Shawn Knabel, Sherry H. Suyu, Vardha N. Bennert, Joshua A. Frieman, Dominique Sluse, Simon Birrer, Frederic Courbin, Christopher D. Fassnacht, Lizvette Villafaña, Peter R. Williams

Physics

Strong-lensing time delays enable the measurement of the Hubble constant (H0) independently of other traditional methods. The main limitation to the precision of time-delay cosmography is mass-sheet degeneracy (MSD). Some of the previous TDCOSMO analyses broke the MSD by making standard assumptions about the mass density profile of the lens galaxy, reaching 2% precision from seven lenses. However, this approach could potentially bias the H0 measurement or underestimate the errors. For this work, we broke the MSD for the first time using spatially resolved kinematics of the lens galaxy in RXJ1131−1231 obtained from the Keck Cosmic …


Predictive Modeling Of Cave Entrance Locations: Relationships Between Surface And Subsurface Morphology, William Blitch, Adia R. Sovie, Benjamin Tobin May 2023

Predictive Modeling Of Cave Entrance Locations: Relationships Between Surface And Subsurface Morphology, William Blitch, Adia R. Sovie, Benjamin Tobin

Faculty, Staff, and Affiliated Publications--KGS

Cave entrances directly connect the surface and subsurface geomorphology in karst landscapes. Understanding the spatial distribution of these features can help identify areas on the landscape that are critical to flow in the karst groundwater system. Sinkholes and springs are major locations of inflow and outflow from the groundwater system, respectively, however not all sinkholes and springs are equally connected to the main conduit system.

Predicting where on the landscape zones of high connectivity exist is a challenge because cave entrances are difficult to detect and imperfectly documented. Wildlife research has a similar issue of understanding the complexities of where …


The Effects Of Prior Calculus Classes On Success In Organic Chemistry, Tori Williamson May 2023

The Effects Of Prior Calculus Classes On Success In Organic Chemistry, Tori Williamson

Theses/Capstones/Creative Projects

Within University of Nebraska – Omaha (UNO) chemistry-based degree programs, organic chemistry along with at least two semesters of calculus are required courses. There is, however, no requirement for the order in which these courses should be taken. This is mainly due to the notion that for chemistry courses, organic chemistry is detached from the typical quantitative concepts studied in other chemistry-based courses. This is untrue, however, as many organic chemistry concepts rely on three-dimensional spatial visualizations and manipulations. Spatial awareness skills are strengthened within higher-level calculus classes. A survey was administered to organic chemistry students enrolled in 2022-2023. The …


The Impact Of Glacial Proximity On The Elemental Composition Of Leachate Derived From Sediment Weathering, Karoline Ford May 2023

The Impact Of Glacial Proximity On The Elemental Composition Of Leachate Derived From Sediment Weathering, Karoline Ford

Theses/Capstones/Creative Projects

This study assesses chemical weathering trends as they relate to glacial retreat. The chemical environment of surfaces exposed to the atmosphere differs significantly from beneath a glacier. As a glacier melts, changes to the biogeochemical processes generate environmental gradients. This study analyzed chemical weathering signals at different distances from a glacial front by comparing the elemental composition of leachate derived from sediments in southeastern Greenland. Samples from proglacial, nonglacial, and moraine locations were weathered in a laboratory setting, and ion chromatography was used to determine the elemental composition of the products. Divergent trends in leachate composition were observed as distance …


The State And Use Of Virtual Tutors, Thomas Anthone May 2023

The State And Use Of Virtual Tutors, Thomas Anthone

Theses/Capstones/Creative Projects

Virtual tutoring is the process by which students and teachers participate in the learning experience in an online, virtual, or networked environment. This process can not only separate the participants from each other in a physical space, but it can also separate them by time. Virtual tutoring can take the form of the group of students coming together synchronously in an online setting and receiving lessons from a single tutor, or by asynchronous learning in which the teacher pre-plans lessons in advance that the students consume on their own time. The advent of online learning technologies and virtual learning environments …


Battery Design, Construction, And Characterization For Small Motor Use Focusing On Anodic Zinc For Electron Flow, Amber Veach May 2023

Battery Design, Construction, And Characterization For Small Motor Use Focusing On Anodic Zinc For Electron Flow, Amber Veach

Chemical Engineering Undergraduate Honors Theses

This thesis explores the construction, characterization, and application of anodic zinc batteries for powering a small electric motor for the ChemE Car competition. Two zinc galvanic cell batteries were studied: zinc-carbon and zinc-air batteries. Prototype batteries were constructed and tested for voltage, amperage, and power production. In the zinc-carbon trials, a 3:1 mixture of manganese dioxide and graphite was determined to be the best cathode for power production. The size which allowed for sufficient power while maintaining the smallest footprint on the car was a zinc can six cm tall and two cm in diameter. Analysis of paper zinc-air battery …


Internship Thesis - Happy Egg Co., Annelise Koster May 2023

Internship Thesis - Happy Egg Co., Annelise Koster

Data Science Undergraduate Honors Theses

This paper outlines a data science internship at Happy Egg Co, a producer of free-range eggs committed to sustainable agriculture practices. The internship focused on analyzing customer data to uncover characteristics of Happy Egg Co's target market and identify potential new markets for expansion.

The internship spanned a period of 10 weeks and involved working with the company's marketing and data science teams to gain practical experience in data cleaning, analysis, and visualization. The focus was on uncovering patterns and trends in customer behavior, preferences, and demographics to inform marketing strategies.

The internship began with an introduction to Happy Egg …


Analyzing Real Life Scenarios Through Linear And Exponential Functions Using Open Pedagogy., Lili Grigorian May 2023

Analyzing Real Life Scenarios Through Linear And Exponential Functions Using Open Pedagogy., Lili Grigorian

Open Educational Resources

This assignment is on linear and exponential growth, which is connected to real life scenarios from students’ everyday life as well as teaches them financial responsibility and awareness of economic issues. Project has five parts. In part 1, students would use digital communication ability by creating a video about the topic from the knowledge they had prior to this project. In part 2 (the Mathematical part) they will use problem-solving and inquiry learning to better understand linear and exponential growth, in part 3 students will use global learning through reading to then annotate article and watch video to then discuss …


Spatial Metabolomics Reveals Glycogen As An Actionable Target For Pulmonary Fibrosis, Lindsey R. Conroy, Harrison A. Clarke, Derek B. Allison, Samuel Santos Valenca, Qi Sun, Tara R. Hawkinson, Lyndsay E. A. Young, Juanita E. Ferreira, Autumn V. Hammonds, Jaclyn B. Dunne, Robert J. Mcdonald, Kimberly J. Absher, Brittany Dong, Ronald C. Bruntz, Kia H. Markussen, Jelena A. Juras, Warren J. Alilain, Jinze Liu, Matthew S. Gentry, Peggi M. Angel, Christopher M. Waters, Ramon C. Sun May 2023

Spatial Metabolomics Reveals Glycogen As An Actionable Target For Pulmonary Fibrosis, Lindsey R. Conroy, Harrison A. Clarke, Derek B. Allison, Samuel Santos Valenca, Qi Sun, Tara R. Hawkinson, Lyndsay E. A. Young, Juanita E. Ferreira, Autumn V. Hammonds, Jaclyn B. Dunne, Robert J. Mcdonald, Kimberly J. Absher, Brittany Dong, Ronald C. Bruntz, Kia H. Markussen, Jelena A. Juras, Warren J. Alilain, Jinze Liu, Matthew S. Gentry, Peggi M. Angel, Christopher M. Waters, Ramon C. Sun

Saha Cardiovascular Research Center Faculty Publications

Matrix assisted laser desorption/ionization imaging has greatly improved our understanding of spatial biology, however a robust bioinformatic pipeline for data analysis is lacking. Here, we demonstrate the application of high- dimensionality reduction/spatial clustering and histopathological annotation of matrix assisted laser desorption/ionization imaging datasets to assess tissue metabolic heterogeneity in human lung diseases. Using metabolic features identified from this pipeline, we hypothesize that metabolic channeling between glycogen and N-linked glycans is a critical metabolic process favoring pulmonary fibrosis progression. To test our hypothesis, we induced pulmonary fibrosis in two different mouse models with lysosomal glycogen utilization deficiency. Both mouse models displayed …


Probing The Structure Of Water On Surfaces: From Water Absorption To Ice Nucleation, Jiarun Zhou May 2023

Probing The Structure Of Water On Surfaces: From Water Absorption To Ice Nucleation, Jiarun Zhou

All Dissertations

Water, essential for all life forms, is the most abundant, simple, yet mysterious molecule in the world. This molecule, consisting of only three atoms, behaves in unexpectedly different ways with the change of environment. In the past, studies of water under different conditions (temperature, pressure, on the surfaces, with confinement) have been conducted using experimental and computational methods. However, the influence of a given environment on water properties is yet to be fully understood. This dissertation studies water at complex interfaces (surfaces with various chemistry and physics properties) in both the liquid and crystalline states. Various heterogeneous systems used to …


Multiple Sequence Alignment Guided By Clam, Emily Light May 2023

Multiple Sequence Alignment Guided By Clam, Emily Light

Senior Honors Projects

For my honors project, I am continuing my research with my academic advisor, Dr. Daniels on creating an approach to the Multiple Sequence Alignment problem in the Rust programming language. This approach will be attached to Dr. Daniels’ CLAM (Clustered Learning for Approximate Manifolds) to enable it to globally and locally align DNA sequences. This research was divided into three separate parts: building the algorithms, implementing them into CLAM’s metric, and measuring and improving the performance of the algorithms. This project includes two separate but related algorithms; Needleman-Wunsch algorithm and the Smith-Waterman algorithm.

The Needleman-Wunsch algorithm takes in two DNA …


Synthesis Of A Phenyl Substituted Zinc Dipyrrin Complex For The Purpose Of Analyzing Aromatic Substitutions On The Characteristics Of Compounds Of This Class, Kole Owen May 2023

Synthesis Of A Phenyl Substituted Zinc Dipyrrin Complex For The Purpose Of Analyzing Aromatic Substitutions On The Characteristics Of Compounds Of This Class, Kole Owen

Undergraduate Honors Theses

The field of photochemistry is as innovative in development as it is broad in application. However, utilization of energy from the sun’s electromagnetic radiation remains secondary to the combustion of fossil fuels for the global energy consumption. This is neither a sustainable nor renewable system, and it has contributed to a major decline in the health of our global environment as the greenhouse gases emission has led to an incline in global temperatures and ocean acidity. To develop effective ways to utilize solar energy, experimental effort is being directed towards the understanding of photosensitizers, molecules which absorb solar radiation and …