Physical Sciences and Mathematics Commons^™

Platform-Independent Estimation Of Human Physiological Time From Single Blood Samples, Yitong Huang, Rosemary Braun

Mathematics Sciences: Faculty Publications

Abundant epidemiological evidence links circadian rhythms to human health, from heart disease to neurodegeneration. Accurate determination of an individual's circadian phase is critical for precision diagnostics and personalized timing of therapeutic interventions. To date, however, we still lack an assay for physiological time that is accurate, minimally burdensome to the patient, and readily generalizable to new data. Here, we present TimeMachine, an algorithm to predict the human circadian phase using gene expression in peripheral blood mononuclear cells from a single blood draw. Once trained on data from a single study, we validated the trained predictor against four independent datasets with …

Topological And Dynamic Properties Of The Sublinearly Morse Boundary And The Quasi-Redirecting Boundary., Jacob D. Garcia, Yulan Qing, Elliott Vest

Mathematics Sciences: Faculty Publications

Sublinearly Morse boundaries of proper geodesic spaces are introduced by Qing, Rafi and Tiozzo. Expanding on this work, Qing and Rafi recently developed the quasi-redirecting boundary, denoted ∂G, to include all directions of metric spaces at infinity. Both boundaries are topological spaces that consist of equivalence classes of quasi-geodesic rays and are quasi-isometrically invariant. In this paper, we study these boundaries when the space is equipped with a geometric group action. In particular, we show that G acts minimally on ∂κG and that contracting elements of G induces a weak north-south dynamic on ∂κG. We also prove, when ∂G exists …

Towards Trust And Reputation As A Service In Society 5.0, Stephan Olariu, Ravi Mukkamala, Meshari Aljohani

Computer Science Faculty Publications

Our paper was inspired by the recent Society 5.0 initiative of the Japanese Government which seeks to create a sustainable human-centric society by putting to work recent advances in technology. One of the key challenges in implementing Society 5.0 is providing trusted and secure services for everyone to use. Motivated by this challenge, this paper makes three contributions that we summarize as follows: Our first main contribution is to propose a novel blockchain and smart contract-based trust and reputation service design to reduce the uncertainty associated with buyer feedback in marketplaces that we expect to see in Society 5.0. Our …

Data Mining Utilizing Various Leveled Clustering Procedures On The Position Of Workers In A Data Innovation Firm, Hussein Alkattan, Noor Razzaq Abbas, Oluwaseun A. Adelaja, Mostafa Abotaleb, Guma Ali

Mesopotamian Journal of Computer Science

The reason of this paper is to clarify dynamic clustering, the divisive and agglomerative dynamic clustering techniques. It fundamentally centers on the concept of the divisive different leveled shapes as well known as the top-down approach by creating a workflow appear, dendrograms, clustered data table which accumulated the clusters based the chosen property, and appear the isolated between each cluster with the assistance of an data mining device called Python. The DIANA dynamic approach utilized data tests of the list of laborers in a Data Advancement firm to induce clusters from the position column inside the data test table. In …

Can Informed Consent Solve Ai Bias?, W. Nicholson Price Ii

Reviews

Artificial intelligence (AI) is moving increasingly rapidly into health care (as indeed into everything else). But it has problems there (as indeed everywhere else!). What’s to be done, in particular, about the deeply embedded biases along racial and other lines that permeate the whole world of health and, as such, are likely to be encoded in AI?

Khiara Bridges gives an answer that seems mild but carries roots of revolution. In Race in the Machine: Racial Disparities in Health and Medical AI, she argues that informed consent is a key lever to pull in fighting these racial disparities. But not …

Environmental Attitudes Of Local Government Scholars In Tiaong, Quezon, Philippines, Justine A. Marasigan, Ma. Larissa Lelu P. Gata

Journal of Public Affairs and Development

This study aimed to analyze the environmental attitudes of local government scholars in Tiaong, Quezon, Philippines. The quantitative research design was used to determine the level of environmental attitudes using the New Ecological Paradigm (NEP) Scale. It was also utilized to examine the relationship between environmental attitudes and independent variables which include demographic characteristics such as age, gender, and economic status, academic background such as student classification, scholastic standing, scholarship privileges, and membership in student and/or youth organizations, and experience with ecological extremes. A total of 301 respondents participated in an online survey administered through Google Forms ®. The respondents …

Critically Interrogating Wolf Eradication And Management Policy Through A Settler Colonial Lens: Toward A Compassionate Future, Karen M. Winter

Antioch University Dissertations & Theses

This largely conceptual multi-article dissertation centers settler colonial theory in a critical interrogation of Wolf eradication and management policy (WEMP) toward the ultimate goal of dismantling injurious structures and systems that brutalize Wolf and other Indigenous animals. Wildlife policy and practice are contemporary manifestations of the long-standing historical project of settler colonialism and its quest for acquisition and ultimate control of Land. Thus, the ongoing hegemonic control of systems of wildlife management and the propensity toward lethal control are also inextricably linked to the oppression of Indigenous worldview about human relationship with the natural world. Settler colonialism, as the nexus …

Actionpoint: An App To Combat Cyberbullying By Strengthening Parent-Teen Relationships, Maddie Juarez, Natali Barragan, Deborah Hall, George K. Thiruvathukal, Yasin Silva

Computer Science: Faculty Publications and Other Works

Overview: Urgent need for intervention tools to mitigate increase in cyberbullying • ActionPoint is based on parent-teen relationship research • App includes interactive modules to improve family communication and online behavior to combat cyberbullying effects • To be presented in the IEEE World Forum on Public Safety Technology 2024.

Conventions, Definitions, Identities, And Other Useful Formulae, Robert A. Mcnees Iv

Physics: Faculty Publications and Other Works

As the name suggests, these notes contain a summary of important conventions, definitions, identities, and various formulas that I often refer to. They may prove useful for researchers working in General Relativity, Supergravity, String Theory, Cosmology, and related areas.

Exploring The Atmospheric And Weather Conditions For Hoar Frost Formation At Or Tambo International Airport: A Case Study Of Ground Aircraft Icing Events For The Period 2017-2023., Thabisile P Z Ntleko Ms, Xolani Matlou Mr

International Journal of Aviation, Aeronautics, and Aerospace

Ground aircraft icing has an adverse effect on the aerodynamic performance of aircrafts as well as the efficient operations of airlines and airports. The South African Weather Service (SAWS) Aviation Weather Centre (AWC) issues forecasts and warnings for the aviation community, which include aerodrome warnings for hoar frost accumulation. The infrequent and notable temporal occurrence of this weather phenomena renders it a rare aviation hazard to warn for, therefore understanding the weather and atmospheric conditions conducive for its formation is important for accurate forecasting. This study analyses 28 incidents of ground aircraft icing events at OR Tambo International Airport, South …

The Impact Of Thunderstorms On Take-Off Data In South Africa, Quinton Jacobs Mr.

International Journal of Aviation, Aeronautics, and Aerospace

Aviation and meteorology are entwined disciplines, as aviation occurs in the atmosphere. Prevailing weather conditions at take-off are of utmost importance to aviation. This determines the payload of the aircraft and runway in use. Forecast verification is essential to aviation as it determines the quality of the forecasting products. The tolerances for take-off data are stringent and slightly relaxed tolerances are used in South Africa by mutual agreement.

There are six aerodromes in South Africa where Take-off Data are produced, in varying climatic conditions as South Africa is in both the tropics and midlatitudes. Thunderstorms are a common occurrence over …

Phosphorescent Carbon Dots Doped Silica Nanomaterials Via Microwave-Assisted And Modified Stöber Methods For Anti-Counterfeiting And Biosensing, Weichao Liu

Dissertations and Theses

Phosphorescent materials are essential in bioimaging, anti-counterfeiting, and other applications due to their prolonged light emission. However, current phosphorescent materials face challenges such as complex synthesis, high costs, and instability. Carbon dots (CDs), with size less than 10 nm, are a promising alternative due to their biocompatibility, tunable optical properties, and simple synthesis. This thesis explores the synthesis of CDs using ethylenediamine (EDA) and phosphoric acid via a microwave-assisted method, followed by silica encapsulation using a modified Stöber process to form CDs@SiO2, aiming to enhance their stability and optical properties. Optical characterization showed a slight blue shift in the excitation …

Recovering Relativistic Effects In Electronic Structure Calculations Of F-Element Single Molecule Magnets, Nathan Roy Loutsch

Dissertations and Theses

There has been a great interest in developing new information technologies. Single molecule magnets (SMMs) are emerging as materials for high density data storage, qubits, and molecular spintronics. SMMs containing lanthanide or actinide centers are of interest due to their potentially high magnetic anisotropy. This would enable the use of SMMs at higher temperatures. Accurately modelling the electronic structure of f-element complexes can be quite challenging. Density Functional Theory (DFT) is a popular choice for optimizing geometry and studying the electronic structure due to its relatively low cost. In certain cases, more accuracy is desired or necessary to predict experimental …

Fluorinated Thiophene Containing Aromatics And Their Polymers For Energy Storage And Semiconductor Applications, Blessing Damilola Ishola

Dissertations and Theses

The development of new fluorinated functional materials that are moisture and air-stable is crucial for the efficient production of n-type organic semiconductors. These semiconductors are integral components in electronic devices such as transistors, diodes, organic semiconductors, organic field-effect transistors, and organic light-emitting diodes. Organic materials have become increasingly popular for designing new semiconductors due to their flexibility compared to inorganic alternatives. By molecularly engineering the band gap and electron delocalization, we can improve the efficiency and performance of semiconductor devices. We design, synthesize, and characterize a new type of donor-acceptor molecule based on the structure-property relationship learned from the literature …

Designing Fluorescent Moscs For Potential Applications In Illicit Drugs Detection, Robyn Nicole Cook

Dissertations and Theses

Illicit and hazardous substances pose a serious effect on the human body which can create longer-term issues on the mental and physical health which potentially lead to fatalities. Current methods for detecting illicit substances include analytical techniques like mass spectrometry (MS) and gas/liquid chromatography (GC/LC) which are known for accuracy and sensitivity. However, these instruments are bulky, costly, time-consuming, and require highly trained personnel. An alternative approach to overcoming these limitations is to employ nanostructured molecule-based chemical sensing technologies that are user-friendly, portable, and cost-effective with the sensitivity for detecting illicit substances. One such candidate is metal-organic super-containers (MOSCs), which …

Modeling Apparent Pb Loss In Zircon U-Pb Geochronology, Glenn R. Sharman, Matthew A. Malkowski

Geosciences Faculty Publications and Presentations

The loss of radiogenic Pb from zircon is known to be a major factor that can cause inaccuracy in the U–Pb geochronological system; hence, there is a need to better characterize the distribution of Pb loss in natural samples. Treatment of zircon by chemical abrasion (CA) has become standard practice in isotope dilution–thermal ionization mass spectrometry (ID-TIMS), but CA is much less commonly employed prior to in situ analysis via laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) or secondary ionization mass spectrometry (SIMS). Differentiating the effects of low levels of Pb loss in Phanerozoic zircon with relatively low-precision in situ U–Pb …

Growing Up Sustainable? Politics Of Race And Youth In Urbanplan, Copenhagen, Max Ritts, Rebecca Rutt

Geography

This paper considers how racialized youth in Denmark negotiate sustainability amid contexts marked by intersecting forms of economic restructuring, progressive neoliberalism, white ethno-nationalism, and green urban planning. Urbanplan is a low-income, notoriously “troubled” Copenhagen neighborhood where we conducted fieldwork for 7 months (2019-2020) with fifteen male youth, aged 17-21. Using ethnography, policy reviews, and interviews with city social workers, we explore how intimate experiences of nature, group-identity, and place attachment here relate to and depart from the structural forces actively reshaping the neighborhood. Our analysis combines Cindi Katz's intersectional political economy approach with recent work on green gentrification, Critical Utopian …

Ethical Decision-Making In Older Drivers During Critical Driving Situations: An Online Experiment, Amandeep Singh, Sarah Yahoodik, Yovela Murzello, Samuel Petkac, Yusuke Yamani, Siby Samuel

Psychology Faculty Publications

The present study examined the impact of aging on ethical decision-making in simulated critical driving scenarios. 204 participants from North America, grouped into two age groups (18–30 years and 65 years and above), were asked to decide whether their simulated automated vehicle should stay in or change from the current lane in scenarios mimicking the Trolley Problem. Each participant viewed a video clip rendered by the driving simulator at Old Dominion University and pressed the space-bar if they decided to intervene in the control of the simulated automated vehicle in an online experiment. Bayesian hierarchical models were used to analyze …

Identifying The Origins Of Business’ Data Breaches Utilizing Covert Timing Channels, Gayle L. Frisbie

Master's Theses and Doctoral Dissertations

Cybersecurity events and data breaches are on the rise and are very costly to businesses. Businesses rely on connectivity and information systems to conduct business, yet those same information systems can be breached and the organization's data exposed. Today, there is a heavy reliance of organizations upon network connections to connect the entire organization in order to conduct business efficiently and from multiple locations. Covert timing channels are a cybersecurity attack method in which malicious actors embed privileged information into normal network traffic without authorization. Malicious actors, by carefully manipulating timing patterns in covert timing channels, can create a hidden …

Unveiling User Perspectives: Exploring Themes In Femtech Mobile App Reviews For Enhanced Usability And Privacy, Nidhi Nellore, Tania Mishra, Michael Zimmer

Computer Science Faculty Research and Publications

Femtech, a growing sector in mobile healthcare technology, caters to women's needs across various life stages with digital solutions like period tracking and pregnancy management apps. Maintaining robust data privacy is crucial due to the sensitive nature of the information involved, such as menstrual cycles and pregnancy status. Our research analyzes user feedback from platforms like the Apple App Store and Google Play Store to understand perceptions of femtech apps, covering accessibility, interface, features, and privacy concerns. Understanding user perspectives helps developers enhance usability and trust, driving further adoption. Prioritizing privacy also fosters industry advancement. This paper stresses the importance …

Remember The Human: A Systematic Review Of Ethical Considerations In Reddit Research, Casey Fiesler, Michael Zimmer, Nicholas Proferes, Sarah A. Gilbert, Naiyan Jones

Computer Science Faculty Research and Publications

Reddit is one of the world's most prominent social media platforms, and also a valuable source of data for internet researchers. However, working with this kind of data also presents novel ethical complications for researchers, including issues around privacy, vulnerable populations, and unintended consequences. This paper describes an analysis of 134 papers that rely on Reddit data while also including some discussion of ethical implications and/or considerations by the researchers. Our analysis of these papers reveals common ethical issues and ethically motivated methodological decisions, as described by the researchers themselves, while also exposing some gaps for further ethical contemplation for …

Mixed Quantum/Classical Theory For Rotationally Inelastic Scattering Of Identical Collision Partners: Revised, Dulat Bostan, Bikramaditya Mandal, Dmitri Babikov

Chemistry Faculty Research and Publications

Mixed quantum/classical theory (MQCT) for the treatment of rotationally inelastic transitions during collisions of two identical molecules, described either as indistinguishable or distinguishable partners, is reviewed. The treatment of two molecules as indistinguishable includes symmetrization of rotational wavefunctions, introduces exchange parity, and leads to state-to-state transition matrix elements different from those in the straightforward treatment of molecules as distinguishable. Moreover, the treatment of collision partners as indistinguishable is eight times faster. Numerical results presented herein for H₂ + H₂, CO + CO and H₂O + H₂O systems indicate good agreement of MQCT calculations …

Scattering In Extreme Environments: General Discussion, Dmitri Babikov

Chemistry Faculty Research and Publications

No abstract provided.

Scattering At Condensed-Phase Surfaces: General Discussion, Dmitri Babikov

Chemistry Faculty Research and Publications

No abstract provided.

Anticancer Drugs Of Lysine Specific Histone Demethylase-1 (Lsd1) Display Variable Inhibition On Nucleosome Substrates, Dulmi Senanayaka, Danyun Zeng, Emre Deniz, Indunil K. Priyankara, Joceline Helmbreck, Owen Schneider, Aashay Mardikar, Aykut Uren, Nicholas J. Reiter

Chemistry Faculty Research and Publications

Lysine specific demethylase-1 (LSD1) serves as a regulator of transcription and represents a promising epigenetic target for anticancer treatment. LSD1 inhibitors are in clinical trials for the treatment of Ewing’s sarcoma (EWS), acute myeloid leukemia, and small cell lung cancer, and the development of robust inhibitors requires accurate methods for probing demethylation, potency, and selectivity. Here, the inhibition kinetics on the H3K4me2 peptide and nucleosome substrates was examined, comparing the rates of demethylation in the presence of reversible [CC-90011 (PD) and SP-2577 (SD)] and irreversible [ORY-1001 (ID) and tranylcypromine (TCP)] inhibitors. Inhibitors were also subject to viability studies in three …

Benzoquinone Ligand-Enabled Ruthenium-Catalyzed Deaminative Coupling Of 2-Aminoaryl Aldehydes And Ketones With Branched Amines For Regioselective Synthesis Of Quinoline Derivatives, Krishna Prasad Gnyawali, Aldiyar Shakenov, Pandula T. Kirinde Arachchige, Chae S. Yi

Chemistry Faculty Research and Publications

The catalytic system generated in situ from the cationic Ru–H complex [(C₆H₆)(PCy₃)(CO)RuH]⁺BF₄– (1) with 2,3,4,5-tetrachloro-1,2-benzoquinone (L1) was found to be highly effective for promoting the deaminative coupling reaction of 2-aminoaryl aldehydes with branched amines to form 2-substituted quinoline products. The analogous deaminative coupling reaction of 2-aminoaryl ketones with branched amines led to the regioselective formation of 2,4-disubstituted quinoline products. A number of biologically active quinoline derivatives including graveolinine and a triplex DNA intercalator have been synthesized by using the catalytic method.

Efficient Synthesis Of Thiazole-Fused Bisnoralcohol Derivatives As Potential Therapeutic Agents, Subrata Roy, Hansa Raj Kc, Sanjay Adhikary, Alexander N. Erickson, Mohammad Abrar Alam

Chemistry Faculty Research and Publications

Thiazole derivatives are known for a wide range of therapeutic properties. Bisnoralcohol is an inexpensive natural product obtained by the biodegradation of sterols. This article describes an efficient synthesis of a library of thiazole-fused bisnoralcohol derivatives. These novel compounds have been studied for their antineoplastic and antibacterial properties, which led to the discovery of hit compounds with therapeutic potential. The antibacterial compound is noncytotoxic and nonhemolytic against cancer cell lines and sheep red blood cells, respectively. Several of the antineoplastic compounds showed activity against human cancer cell lines with growth inhibition at submicromolar concentration.

Mechanism Of Action Of Kl-50, A Candidate Imidazotetrazine For The Treatment Of Drug-Resistant Brain Cancers, Eric D. Huseman, Anna Lo, Olga Fedorova, James L. Elia, Susan E. Gueble, Kingson Lin, Ranjini K. Sundaram, Jooneseok Oh, Jinchan Liu, Fabian Menges, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Victor S. Batista, Jason M. Crawford, Anna M. Pyle, Ranjit S. Bindra, Seth B. Herzon

Chemistry Faculty Research and Publications

Aberrant DNA repair is a hallmark of cancer, and many tumors display reduced DNA repair capacities that sensitize them to genotoxins. Here, we demonstrate that the differential DNA repair capacities of healthy and transformed tissue may be exploited to obtain highly selective chemotherapies. We show that the novel N3-(2-fluoroethyl)imidazotetrazine “KL-50” is a selective toxin toward tumors that lack the DNA repair protein O⁶-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O⁶-alkylguanine lesions. We establish that KL-50 generates DNA interstrand cross-links (ICLs) by a multistep process comprising DNA alkylation to generate an O⁶-(2-fluoroethyl)guanine (O⁶FEtG) …

Combination Chemotherapy Optimization With Discrete Dosing, Temitayo Ajayi, Seyedmohammadhossein Hosseinian, Andrew J Schaefer, Clifton D Fuller

Faculty, Staff and Student Publications

Chemotherapy drug administration is a complex problem that often requires expensive clinical trials to evaluate potential regimens; one way to alleviate this burden and better inform future trials is to build reliable models for drug administration. This paper presents a mixed-integer program for combination chemotherapy (utilization of multiple drugs) optimization that incorporates various important operational constraints and, besides dose and concentration limits, controls treatment toxicity based on its effect on the count of white blood cells. To address the uncertainty of tumor heterogeneity, we also propose chance constraints that guarantee reaching an operable tumor size with a high probability in …

A Signal Injection Attack Against Zero Involvement Pairing And Authentication For The Internet Of Things, Isaac Ahlgren, Jack West, Kyuin Lee, George K. Thiruvathukal, Neil Klingensmith

Computer Science: Faculty Publications and Other Works

Zero Involvement Pairing and Authentication (ZIPA) is a promising technique for auto-provisioning large networks of Internet-of-Things (IoT) devices. In this work, we present the first successful signal injection attack on a ZIPA system. Most existing ZIPA systems assume there is a negligible amount of influence from the unsecured outside space on the secured inside space. In reality, environmental signals do leak from adjacent unsecured spaces and influence the environment of the secured space. Our attack takes advantage of this fact to perform a signal injection attack on the popular Schurmann & Sigg algorithm. The keys generated by the adversary with …