Open Access. Powered by Scholars. Published by Universities.®

Physical Sciences and Mathematics Commons

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 33601 - 33630 of 291660

Full-Text Articles in Physical Sciences and Mathematics

The False Promise That Guilt-Free Flying Is Just Around The Corner, Amanda Braitman Dec 2023

The False Promise That Guilt-Free Flying Is Just Around The Corner, Amanda Braitman

Capstones

Airlines are spending big bucks advertising “sustainable aviation fuel,” but some experts say it's greenwashing.

https://docs.google.com/document/d/19ZejyJBgPGgleNXOWrHXKGF5WI1poQ8OyxSKg8PBNZI/edit?usp=sharing


Probing And Enhancing The Reliance Of Transformer Models On Poetic Information, Almas Abdibayev Dec 2023

Probing And Enhancing The Reliance Of Transformer Models On Poetic Information, Almas Abdibayev

Dartmouth College Ph.D Dissertations

Transformer models have achieved remarkable success in the widest variety of domains, spanning not just a multitude of tasks within natural language processing, but also those in computer vision, speech, and reinforcement learning. The key to this success is largely attributed to the self-attention mechanism, particularly its ability to scale in performance as it grows in the number of parameters. Extensive effort has been underway to study the major linguistic properties learned by these models during the course of their pretraining. However, the role of certain finer linguistic phenomena present in language and their utilization by Transformers has not been …


Mutational Analysis Of The Nitrogenase Carbon Monoxide Protective Protein Cown Reveals That A Conserved C‑Terminal Glutamic Acid Residue Is Necessary For Its Activity, Dustin L. Willard, Joshuah J. Arellano, Mitch Underdahl, Terrence M. Lee, Avinash S. Ramaswamy, Gabriella Fumes, Agatha Kliman, Emily Y. Wong, Cedric P. Owens Dec 2023

Mutational Analysis Of The Nitrogenase Carbon Monoxide Protective Protein Cown Reveals That A Conserved C‑Terminal Glutamic Acid Residue Is Necessary For Its Activity, Dustin L. Willard, Joshuah J. Arellano, Mitch Underdahl, Terrence M. Lee, Avinash S. Ramaswamy, Gabriella Fumes, Agatha Kliman, Emily Y. Wong, Cedric P. Owens

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Nitrogenase is the only enzyme that catalyzes the reduction of nitrogen gas into ammonia. Nitrogenase is tightly inhibited by the environmental gas carbon monoxide (CO). Many nitrogen fixing bacteria protect nitrogenase from CO inhibition using the protective protein CowN. This work demonstrates that a conserved glutamic acid residue near the C-terminus of Gluconacetobacter diazotrophicus CowN is necessary for its function. Mutation of the glutamic acid residue abolishes both CowN’s protection against CO inhibition and the ability of CowN to bind to nitrogenase. In contrast, a conserved C-terminal cysteine residue is not important for CO protection by CowN. Overall, this work …


The Tor Algebra Of Trimmings Of Gorenstein Ideals, Luigi Ferraro, Alexis Hardesty Dec 2023

The Tor Algebra Of Trimmings Of Gorenstein Ideals, Luigi Ferraro, Alexis Hardesty

School of Mathematical & Statistical Sciences Faculty Publications

Let (R,\mathfrak m,\Bbbk ) be a regular local ring of dimension 3. Let I be a Gorenstein ideal of R of grade 3. Buchsbaum and Eisenbud proved that there is a skew-symmetric matrix of odd size such that I is generated by the sub-maximal pfaffians of this matrix. Let J be the ideal obtained by multiplying some of the pfaffian generators of I by \mathfrak m; we say that J is a trimming of I. Building on a recent paper of Vandebogert, we construct an explicit free resolution of R/J and compute a partial DG algebra structure on this …


E-Governance: The Implication Of Next Social Generation Welfare Information System, Yaya Mulyana Abdul Aziz, Andre Ariesmansyah Dec 2023

E-Governance: The Implication Of Next Social Generation Welfare Information System, Yaya Mulyana Abdul Aziz, Andre Ariesmansyah

Smart City

Accelerating bureaucracy can be performed by e-governance present in order to improve the quality of government administration in the world. E-governance draft is closely related to the development of information and communication technology (ICT) globally. One form of embodiment of e-governance is the implementation of a smart city. smart cities are expected to be able to become a liaison between the demands of the community in appropriate, effective, and efficient services from the city government, by utilizing ICT. There are various related definitions of smart city in this world. One of them is as explained by Nam and Pardo who …


Forests As Social Safety Nets During The Covid-19 Lockdowns: Evidence From India, Alder Keleman Saxena Dec 2023

Forests As Social Safety Nets During The Covid-19 Lockdowns: Evidence From India, Alder Keleman Saxena

Sustainability Seminar Series

This presentation reports on research assessing the social-ecological dynamics of the Covid-19 lockdowns in India in 2020 and 2021. Preliminary findings of research in forest- adjacent communities in three states (Assam, Madhya Pradesh, and Himachal Pradesh) suggest that while forest resources did serve as a buffer for some of the most vulnerable households, they did not stand in as a full substitute for the market-derived goods and income opportunities curtailed by the lockdowns. Findings from the research to-date suggest two major conclusions: first, the ecological context (including the seasonal timing) of the lockdowns influenced the extent to which forest communities …


Ohio Recovery Housing: Resident Risk And Outcomes Assessment, Elyjiah Potter, Bivin Sadler Dec 2023

Ohio Recovery Housing: Resident Risk And Outcomes Assessment, Elyjiah Potter, Bivin Sadler

SMU Data Science Review

Addiction and substance abuse disorder is a significant problem in the United States. Over the past two decades, the United States has faced a boom in substance abuse, which has resulted in an increase in death and disruption of families across the nation. The State of Ohio has been particularly hard hit by the crisis, with overdose rates nearly doubling the national average. Established in the mid 1970’s Sober Living Housing is an alcohol and substance use recovery model emphasizing personal responsibility, sober living, and community support. This model has been adopted by the Ohio Recovery Housing organization, which seeks …


Deep Learning Image Analysis To Isolate And Characterize Different Stages Of S-Phase In Human Cells, Kevin A. Boyd, Rudranil Mitra, John Santerre, Christopher L. Sansam Dec 2023

Deep Learning Image Analysis To Isolate And Characterize Different Stages Of S-Phase In Human Cells, Kevin A. Boyd, Rudranil Mitra, John Santerre, Christopher L. Sansam

SMU Data Science Review

Abstract. This research used deep learning for image analysis by isolating and characterizing distinct DNA replication patterns in human cells. By leveraging high-resolution microscopy images of multiple cells stained with 5-Ethynyl-2′-deoxyuridine (EdU), a replication marker, this analysis utilized Convolutional Neural Networks (CNNs) to perform image segmentation and to provide robust and reliable classification results. First multiple cells in a field of focus were identified using a pretrained CNN called Cellpose. After identifying the location of each cell in the image a python script was created to crop out each cell into individual .tif files. After careful annotation, a CNN was …


Investigation Into A Practical Application Of Reinforcement Learning For The Stock Market, Philip Traxler, Sadik Aman, Will Rogers, Allyn Okun Dec 2023

Investigation Into A Practical Application Of Reinforcement Learning For The Stock Market, Philip Traxler, Sadik Aman, Will Rogers, Allyn Okun

SMU Data Science Review

A major problem of the financial industry is the ability to adapt their trading strategies at the same rate the market evolves. This paper proposes a solution using existing Reinforcement Learning libraries to help find new strategies at a practical scale. Using a wide domain of ticker symbols, an algorithm is trained in an environment that better represents reality. The supplied decision-making algorithm is tested using recorded data from the U.S stock market from 2000 through 2022. The results of this research show that existing techniques are statistically better than making decisions at random. With this result, this research shows …


Differentiation Of Human, Dog, And Cat Hair Fibers Using Dart Tofms And Machine Learning, Laura Ahumada, Erin R. Mcclure-Price, Chad Kwong, Edgard O. Espinoza, John Santerre Dec 2023

Differentiation Of Human, Dog, And Cat Hair Fibers Using Dart Tofms And Machine Learning, Laura Ahumada, Erin R. Mcclure-Price, Chad Kwong, Edgard O. Espinoza, John Santerre

SMU Data Science Review

Hair is found in over 90% of crime scenes and has long been analyzed as trace evidence. However, recent reviews of traditional hair fiber analysis techniques, primarily morphological examination, have cast doubt on its reliability. To address these concerns, this study employed machine learning algorithms, specifically Linear Discriminant Analysis (LDA) and Random Forest, on Direct Analysis in Real Time time-of-flight mass spectra collected from human, cat, and dog hair samples. The objective was to develop a chemistry- and statistics-based classification method for unbiased taxonomic identification of hair. The results of the study showed that LDA and Random Forest were highly …


Impact Of Covid-19 On Recruitment Of High School Athletes To Di Track And Field, Christopher Haub, Jon Paugh, Alonso Salcido, Monnie Mcgee Dec 2023

Impact Of Covid-19 On Recruitment Of High School Athletes To Di Track And Field, Christopher Haub, Jon Paugh, Alonso Salcido, Monnie Mcgee

SMU Data Science Review

Due to COVID-19, in the spring of 2020, the NCAA gave scholarship athletes an extra year of eligibility but did not increase the number of scholarships a school could issue. This potentially led to increased competition for scholarships as coaches could choose between retaining athletes or recruiting new ones. Furthermore, the Spring 2020 track and field season for high school seniors ended early – limiting high school athletes’ chance to get their best scores, and interrupting student to college interaction. This research looks specifically at the impact of COVID-19, and the resulting NCAA policy changes, on the recruitment to DI …


A Prompt Engineering Approach To Creating Automated Commentary For Microsoft Self-Help Documentation Metric Reports Using Chatgpt, Ryan Herrin, Luke Stodgel, Brian Raffety Dec 2023

A Prompt Engineering Approach To Creating Automated Commentary For Microsoft Self-Help Documentation Metric Reports Using Chatgpt, Ryan Herrin, Luke Stodgel, Brian Raffety

SMU Data Science Review

Microsoft collects an immense amount of data from the users of their product-self-help documentation. Employees use this data to identify these self-help articles' performance trends and measure their impact on business Key Performance Indicators (KPIs). Microsoft uses various tools like Power BI and Python to analyze this data. The problem is that their analysis and findings are summarized manually. Therefore, this research will improve upon their current analysis methods by applying the latest prompt engineering practices and the power of ChatGPT's large language models (LLMs). Using VBA code, Microsoft Excel, and the ChatGPT API as an Excel add-in, this research …


The Impact Of The Covid-19 Pandemic On Faculty Productivity And Gender Inequalities In Stem Disciplines, Monnie Mcgee, Raag Patel, Roslyn Smith, Satvik Ajmera Dec 2023

The Impact Of The Covid-19 Pandemic On Faculty Productivity And Gender Inequalities In Stem Disciplines, Monnie Mcgee, Raag Patel, Roslyn Smith, Satvik Ajmera

SMU Data Science Review

Women and minorities within STEM disciplines historically encounter obstacles in academic advancement, a situation compounded by the COVID-19 pandemic due to the imposition of additional responsibilities like caregiving. This study meticulously probes into the pandemic's influence on traditional academic productivity metrics – specifically publication and submission frequency, citation volume, and leadership in scholarly entities, by employing Natural Language Processing to extract and analyze data from key journals within various scientific domains. A critical revelation from the research indicates a notable downturn in publication activity during 2021, potentially attributed to pandemic-induced disruptions, with a compensatory surge observed in 2022. Although a …


Predicting Land Reclamation Of Bond Released Surface Mines, Kendall Scott, Austin Webb, Tadd Backus, Robert Slater Dec 2023

Predicting Land Reclamation Of Bond Released Surface Mines, Kendall Scott, Austin Webb, Tadd Backus, Robert Slater

SMU Data Science Review

Accurately measuring the recovery of released surface mines in the UnitedStates poses crucial challenges. This study aims to develop a prediction of land classification, that considers various environmental and coal mine variables. By utilizing this prediction, the researchers and environmentalists (specifically Appalachian Voices, the group heading this research) can better understand the relevant factors for successful reclamation. Efficient management of mine recovery is essential for environmental sustainability, regulatory compliance, and resource utilization. This study focuses on the Appalachian Forest area, which risks becoming a net carbon source (a place that emits more carbon than it absorbs) due to mine recovery. …


Utilizing Computer Vision For Automated Cellular Microscopy, Ahmed Awadallah, Ryan Bass, James Burke, Robert Price, John Santerre Dec 2023

Utilizing Computer Vision For Automated Cellular Microscopy, Ahmed Awadallah, Ryan Bass, James Burke, Robert Price, John Santerre

SMU Data Science Review

Abstract. Post-acquisition data analysis of microscopy images is a vital yet time-consuming process for researchers. Quantitative fields such as biology and microbiology often require using images as primary data sources. Finding methods to automate this process would increase the throughput, quality, and reproducibility. This research aims to provide a novel end-to-end pipeline that reduces the workload on researchers in identifying cell cytoplasm and nuclei while creating a process that can scale to the researcher's needs. The proposed methodology utilizes various image-processing techniques to rapidly identify the boundaries of cells and nuclei, including filtering, thresholding, and deep learning. The results …


Development Of An Optical Test Bed For The Fabrication And Characterisation Of An Analog Holographic Wavefront Sensor, Emma Branigan, Andreas Zepp, Suzanne Martin, Matthew Sheehan, Szymon Gladysz, Kevin Murphy Dec 2023

Development Of An Optical Test Bed For The Fabrication And Characterisation Of An Analog Holographic Wavefront Sensor, Emma Branigan, Andreas Zepp, Suzanne Martin, Matthew Sheehan, Szymon Gladysz, Kevin Murphy

Conference Papers

A new holographic recording setup has been developed for the fabrication of single- and multi-mode photopolymer-based analog holographic wavefront sensors. A second setup has been built and used to characterise the sensor at several wavelengths.


Relative Effectiveness Of A Radionuclide (210pb), Surface Elevation Table (Set), And Lidar At Monitoring Mangrove Forest Surface Elevation Change, Richard Mackenzie, Ken Krauss, Nicole Cormier, Eugene Eperiam, Jan Van Aardt, Ali Rouzbeh-Kargar, Jessica Grow, Val Klump Dec 2023

Relative Effectiveness Of A Radionuclide (210pb), Surface Elevation Table (Set), And Lidar At Monitoring Mangrove Forest Surface Elevation Change, Richard Mackenzie, Ken Krauss, Nicole Cormier, Eugene Eperiam, Jan Van Aardt, Ali Rouzbeh-Kargar, Jessica Grow, Val Klump

Articles

Sea-level rise (SLR) is one of the greatest future threats to mangrove forests. Mangroves have kept up with or paced past SLR by maintaining their forest floor elevation relative to sea level through root growth, sedimentation, and peat development. Monitoring surface elevation change (SEC) or accretion rates allows us to understand mangrove response to SLR and prioritizes resilient ecosystems for conservation or vulnerable ecosystems for restoration. We compared three methods to measure SEC and accretion in mangrove forests: 210Pb, surface elevation tables (SETs), and a terrestrial light detection and ranging system (compact biomass LiDAR—CBL). Lead-210 accretion rates were not significantly …


The Dose-Response Effect Of Aerobic Exercise On Inflammation In Colon Cancer Survivors, Justin C. Brown, Stephanie L.E. Compton, Jeffrey A. Meyerhardt, Guillaume Spielmann, Shengping Yang Dec 2023

The Dose-Response Effect Of Aerobic Exercise On Inflammation In Colon Cancer Survivors, Justin C. Brown, Stephanie L.E. Compton, Jeffrey A. Meyerhardt, Guillaume Spielmann, Shengping Yang

School of Medicine Faculty Publications

Background; Physical activity after surgical resection for colon cancer is associated with significantly longer disease-free survival. Inflammation is hypothesized to mediate the association between physical activity and disease-free survival in colon cancer. Methods; In this exploratory analysis of a randomized dose-response trial, 39 colon cancer survivors who completed standard therapy were stratified by cancer stage and randomized in a 1;1;1 ratio to one of three treatment groups for 24 weeks of usual-care control, 150 min/wk of moderate-intensity aerobic exercise (low-dose), or 300 min/wk of moderate-intensity aerobic exercise (high-dose). Inflammation outcomes included high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL6), and soluble tumor …


12.04.2023 Orsp Connect, Liz Williamson Dec 2023

12.04.2023 Orsp Connect, Liz Williamson

ORED Newsletter

Week of December 4, 2023


The High Energy X-Ray Probe (Hex-P): A New Window Into Neutron Star Accretion, R.M. Ludlam, C. Malacaria, E. Sokolova-Lapa, F. Fuerst, P. Pradhan, A.W. Shaw, K. Pottschmidt, S. Pike, G. Vasilopoulos, J. Wilms, J.A. Garcia, K. Madsen, D. Stern, C. Maitra, M. Del Santo, D.J. Walton, M.C. Brumback, J. Van Den Eijnden Dec 2023

The High Energy X-Ray Probe (Hex-P): A New Window Into Neutron Star Accretion, R.M. Ludlam, C. Malacaria, E. Sokolova-Lapa, F. Fuerst, P. Pradhan, A.W. Shaw, K. Pottschmidt, S. Pike, G. Vasilopoulos, J. Wilms, J.A. Garcia, K. Madsen, D. Stern, C. Maitra, M. Del Santo, D.J. Walton, M.C. Brumback, J. Van Den Eijnden

Publications

Accreting neutron stars (NSs) represent a unique laboratory for probing the physics of accretion in the presence of strong magnetic fields (B ≳ 108 G). Additionally, the matter inside the NS itself exists in an ultra-dense, cold state that cannot be reproduced in Earth-based laboratories. Hence, observational studies of these objects are a way to probe the most extreme physical regimes. Here we present an overview of the field and discuss the most important outstanding problems related to NS accretion. We show how these open questions regarding accreting NSs in both low-mass and high-mass X-ray binary systems can …


Characterizing Quirky Signals, Joshua D. Forsyth Dec 2023

Characterizing Quirky Signals, Joshua D. Forsyth

Theses and Dissertations

Large collider facilities such as the Large Hadron Collider (LHC) employ a variety of search methods in hopes of finding new particles. It may be that new physics beyond the SM is waiting to be discovered at energies accessible to the LHC. Quirks are particles charged under a new confining gauge group with masses much larger than their confinement scale. This project details the dynamics of quirks, as well as the production and decay of electrically charged bound states of scalar quirks. The cross section for these states is compared to existing Wγ resonance searches at the LHC. Such a …


In Vitro Observation Of Optical Changes In Whole Blood Due To Injection Of Glucose Solution, James Gordon Harkness Dec 2023

In Vitro Observation Of Optical Changes In Whole Blood Due To Injection Of Glucose Solution, James Gordon Harkness

Theses and Dissertations

Significance: While the optical properties of blood have been extensively studied, the influence of glucose concentration on blood optics remains unquantified. This is information which could be used to develop a noninvasive blood glucose monitor. Aim: This in vitro study investigated the optics of blood. Time-dependent effects and various methods of introducing glucose into blood samples were examined. The study aimed to quantify how alterations in glucose levels impacted blood optics across 14 distinct NIR wavelengths. Approach: Blood in a cuvette was exposed to light, and the reflected and transmitted light was captured in integrating spheres. 14 distinct wavelengths from …


First Order Approximation On The Basilica Julia Set, Xintan Xia, Taryn Flock Dec 2023

First Order Approximation On The Basilica Julia Set, Xintan Xia, Taryn Flock

Mathematics, Statistics, and Computer Science Honors Projects

We consider the basilica Julia set of the quadratic polynomial P (z) = z^2 - 1, with its successive graph approximations defined in terms of the external ray parametrization of the set. Following the model of Kigami and later Strichartz, we exploit these graph approximations to define derivatives of functions defined on the fractal, an endeavor complicated by asymmetric neighborhood behaviors at approximated vertex points across levels, and by the topology of these vertices. We hence differentiate even and odd levels of approximations of the Julia set and construct, accordingly, normal derivatives corresponding to each level category at the vertices, …


In-Depth Geochemical Analysis Of Turbidite-Associated Shales Of The Pindos Basin, Greece, Jonathon Michael Sevy Dec 2023

In-Depth Geochemical Analysis Of Turbidite-Associated Shales Of The Pindos Basin, Greece, Jonathon Michael Sevy

Theses and Dissertations

Detailed geochemical analysis of the turbidite-associated shales of the Cretaceous Katafito Formation, Greece, reveals important details regarding the paleoenvironment, paleoproductivity, and regional tectonics of the Pindos Basin. The Katafito Formation was deposited along an active margin at the early onset of closure of the Tethys Sea in the Pindos sub-basin. While careful studies of the coarse clastic component of turbidites are common, this study consisted of a detailed geochemical characterization of the fine-grained portions, which helped reveal paleoenvironmental information about the basin. This study combined organic and inorganic geochemistry utilizing elemental, mineralogical, and organic chemical signatures from fine-grained turbidite-associated sediments …


Paleoclimate Of The Peruvian Andean Highlands During The Late Holocene, Jarunetr Sae-Lim Dec 2023

Paleoclimate Of The Peruvian Andean Highlands During The Late Holocene, Jarunetr Sae-Lim

Arts & Sciences Graduate Student Theses and Dissertations

The tropical and central Andean highlands (>4,000 m above sea level) supply critical freshwater resources to the Amazon Basin, supporting large communities in mountain regions and lowlands. Due to the scarcity of historical weather data spatially and temporally, it is challenging to quantify hydroclimate and environmental responses to anthropogenic climate change. Paleoclimate reconstruction and modeling can provide critical insights into key hydroclimate processes and how hydroclimate in this region has responded to climate change and variability through time. However, biomarker-based paleoclimate proxy reconstructions are still very rare in this region. This dissertation quantifies local-scale and regional-scale hydroclimate and environmental …


How Are Oregon's Rural Indigenous Communities Overcoming Water Access Issues?, Tyren John Thompson Dec 2023

How Are Oregon's Rural Indigenous Communities Overcoming Water Access Issues?, Tyren John Thompson

Dissertations and Theses

This study investigates how water insecurity affects Indigenous communities in Grand Ronde, Warm Springs, and Umatilla, Oregon, through loss of clean drinking water, access to culturally significant foods, and exposure to pollution. Each community offers innovative solutions drawing on their Indigenous knowledge to overcome water supply challenges. Communities with more resources are better equipped to cope with water insecurity and environmental degradation.


Water Quality And Road Salt In New Jersey, Deborah Kratzer Dec 2023

Water Quality And Road Salt In New Jersey, Deborah Kratzer

Sustainability Seminar Series

Water quality monitoring data show a long-term trend of increasing chloride and total dissolved solids (TDS) concentrations in NJ surface waters and increasing exceedances of standards for aquatic life and drinking water. In this presentation, Debbie Kratzer will review the data linking road salt use with these trends, sustainability of winter deicing practices, and approaches to reverse these negative water quality trends.


Analyzing The Shark Paleoecology Of Coastal Georgia From The Miocene And Pliocene Epochs, Joshua Lee Clark, Benjamin Angalet Dec 2023

Analyzing The Shark Paleoecology Of Coastal Georgia From The Miocene And Pliocene Epochs, Joshua Lee Clark, Benjamin Angalet

Georgia Journal of Science

The field of shark paleoecology often yields indecisive conclusions based on the limited fossilization of their anatomical structures, with the exception of their teeth. The majority of the Atlantic coast has been studied regarding the presence of certain prehistoric shark species from the Miocene, Pliocene, and Pleistocene epochs. However, information pertaining to the Georgia coast and understanding its potential community structure is relatively understudied. This study was conducted in which thousands of fossil shark specimens and subsequent marine fauna were collected from dredge spoils created by the US Army Corps of Engineers (USACE): Savannah District. A total of 5,127 fossil …


Advanced Separations And Mass Spectrometry Data Acquisition Strategies To Improve Sensitivity And Throughput In Single-Cell Proteomics, Thy Truong Dec 2023

Advanced Separations And Mass Spectrometry Data Acquisition Strategies To Improve Sensitivity And Throughput In Single-Cell Proteomics, Thy Truong

Theses and Dissertations

Single Cell Proteomics (SCP) is an emerging discipline that contributes to a deeper understanding of individual cells' essential components. In biological systems, individual cells exhibit remarkable diversity, showcasing distinct proteomic profiles and functions. Mass Spectrometry (MS)-based techniques have become essential tools for exploring the proteomes of single cells with remarkable precision. While traditional bulk proteomics methods have been invaluable in revealing the overall protein composition of biological samples, they fall short in capturing the subtle nuances and heterogeneity among individual cells in a population. This limitation emphasizes the need for more targeted and detailed analyses to uncover the protein makeup …


Engineering Exosomes To Specifically Target The Mitochondria Of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong Bi Dec 2023

Engineering Exosomes To Specifically Target The Mitochondria Of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong Bi

Michigan Tech Publications

Mitochondrial dysfunction is associated with various health conditions, including cardiovascular and neurodegenerative diseases. Mitochondrial-targeting therapy aims to restore or enhance mitochondrial function to treat or alleviate these conditions. Exosomes, small vesicles that cells secrete, containing a variety of biomolecules, are critical in cell-to-cell communication and have been studied as potential therapeutic agents. Exosome-based therapy has the potential to treat both cardiovascular and neurodegenerative diseases. Combining these two approaches involves using exosomes as carriers to transport mitochondrial-targeting agents to dysfunctional or damaged mitochondria within target cells. This article presents a new technique for engineering brain-derived exosomes that target mitochondria and has …