Physical Sciences and Mathematics Commons^™

An Innovative Restoration Mode “Macrophytes–Fishes–Benthons–Birds” Implemented In Aesthetic Plateau Wetlands, Junxing Yang, Xiaoai Wang, Xiaofu Pan, Yuanwe Zhang, Heqi Wu, Anli Wu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Affected by both increasing human activities and climate change, Yunnan Plateau lakes were faced with threats such as water level decreasing, water-body reducing, and severe pollution. Many indigenous species were endangered or even disappeared. The ecological restorations implemented since 1980s almost all used alien species. As an inevitable result, severe negative impacts from alien species were observed on the Plateau wetland ecosystem and indigenous species. To solve these problems, with the support of relevant projects, an innovative restoration mode mainly with indigenous flag-species “macrophytes – fishes – benthons – birds” was proposed. This innovative mode was implemented respectively in Dianchi …

Control Of Invasive Plant Spartina Alterniflora: Concept, Technology And Practice, Baohua Xie, Guangxuan Han

Bulletin of Chinese Academy of Sciences (Chinese Version)

Alien Species Spartina alterniflora occupy the living space of native animals and plants, and lead to the reduction of biodiversity in the intertidal zone and wetland ecological service functions. Therefore, it is urgent to curb the rapid expansion of S. alterniflora in China’s coastal areas. This paper introduced the invasion situation and main ecological hazards of S. alterniflora in China, as well as put forward the concept of S. alterniflora control of “hazard assessment – zoning control – monitoring and early warning”. We summarized the control technologies of S. alterniflora at home and abroad and the current situation of S. …

Spatial Agglomeration And Environmental Effects Of Heavy Polluting Industries In China: Characteristics And Enlightenment, Hongyang Chen, Jianhui Yu, Wenzhong Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Heavy polluting industries are the important sources of industrial pollutant. Understanding the spatial agglomeration characteristics, influencing factors, agglomeration mechanism and environmental effects of China’s heavy polluting industries can help identify potential pollution risk areas to cope with increasingly severe environmental pollution problems. Based on the industrial economic data from 1999 to 2021, the spatial distribution and agglomeration characteristics of heavy polluting industries are characterized. It is found that: (1) Shandong, Jiangsu, Zhejiang, and Guangdong are the regions with high output value of the development of heavy polluting industries in the past 20 years, while Xinjiang, Inner Mongolia, Shanxi, Shaanxi, Henan, …

Five Issues And Countermeasures Of China Cropland Resource Use, Sijing Ye, Changqing Song, Changxiu Cheng, Peichao Gao, Shi Shen, Wangshu Mu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Understand the cropland use situation, analyze management countermeasures, and explore the regional suitable cropland use mode are important prerequisites for the implementation of the strictest protection of cultivated land strategy with Chinese characteristics. At present, the cropland resource utilization in China is facing the five issues of non-agricultural, non-grain, fragmentation, marginalization, and ecological degradation. This study estimates the spatial-temporal changes of these cropland use issues in China, analyzes the challenges of cropland use governance from the aspects of complex driving factors, phase characteristics, cognitive differences of responsible subjects, and dynamic changes of external factors. On this basis, the countermeasures of …

Prt543, A Protein Arginine Methyltransferase 5 Inhibitor, In Patients With Advanced Adenoid Cystic Carcinoma: An Open-Label, Phase I Dose-Expansion Study, Renata Ferrarotto, Paul Swiecicki, Dan Zandberg, Robert Baiocchi, Robert Wesolowski, Cristina Rodriguez, Meredith Mckean, Hyunseok Kang, Varun Monga, Rajneesh Nath, Neil Palmisiano, Naveen Babbar, William Sun, Glenn Hanna

Department of Medical Oncology Faculty Papers

OBJECTIVES: Currently, no systemic treatments are approved for patients with recurrent and/or metastatic (R/M) adenoid cystic carcinoma (ACC). PRT543, a protein arginine methyltransferase 5 inhibitor that downregulates NOTCH1 and MYB signalling in tumours, is a potential candidate for R/M ACC treatment. We report the safety, tolerability and preliminary efficacy of PRT543 in a dose-expansion cohort of patients with R/M ACC.

MATERIALS AND METHODS: This phase I multicentre, open-label, sequential-cohort, dose-escalation and dose-expansion study (NCT03886831) enrolled patients with advanced solid tumours and select haematologic malignancies. Dose-escalation study design and results were reported previously. In the dose expansion, patients with R/M ACC …

Stereotactic Mr-Guided On-Table Adaptive Radiation Therapy (Smart) For Borderline Resectable And Locally Advanced Pancreatic Cancer: A Multi-Center, Open-Label Phase 2 Study, Michael Chuong, Percy Lee, Daniel Low, Joshua Kim, Kathryn Mittauer, Michael Bassetti, Carri Glide-Hurst, Ann Raldow, Yingli Yang, Lorraine Portelance, Kyle Padgett, Bassem Zaki, Rongxiao Zhang, Hyun Kim, Lauren Henke, Alex Price, Joseph Mancias, Christopher Williams, John Ng, Ryan Pennell, M Raphael Pfeffer, Daphne Levin, Adam Mueller, Karen Mooney, Patrick Kelly, Amish Shah, Luca Boldrini, Lorenzo Placidi, Martin Fuss, Parag Jitendra Parikh

Department of Radiation Oncology Faculty Papers

BACKGROUND AND PURPOSE: Radiation dose escalation may improve local control (LC) and overall survival (OS) in select pancreatic ductal adenocarcinoma (PDAC) patients. We prospectively evaluated the safety and efficacy of ablative stereotactic magnetic resonance (MR)-guided adaptive radiation therapy (SMART) for borderline resectable (BRPC) and locally advanced pancreas cancer (LAPC). The primary endpoint of acute grade ≥ 3 gastrointestinal (GI) toxicity definitely related to SMART was previously published with median follow-up (FU) 8.8 months from SMART. We now present more mature outcomes including OS and late toxicity.

MATERIALS AND METHODS: This prospective, multi-center, single-arm open-label phase 2 trial (NCT03621644) enrolled 136 …

Taking Science To The Streets: Participatory Research Approaches To Improve Environment, Health, And Quality Of Life In Urban Areas, Na'taki Osborne Jelks

Sustainability Seminar Series

Environmental justice communities, those disproportionately affected by pollutants, are simultaneously exposed to multiple environmental stressors and also experience social and cultural factors that may heighten their health risks in comparison to other communities. Availability of fine-grained, community-level data is limited to support said communities’ appeals for public health practice, planning, and policy changes. In Northwest Atlanta, Georgia’s Proctor Creek Watershed community residents (watershed researchers), academics, and non-profit organizations have leveraged local, community knowledge; community science methods; and participatory approaches to identify, document, and analyze the impacts of local environmental hazards and quality of life stressors. This highly collaborative and interdisciplinary …

Social Justice Mathematics: Classroom Practices That Give Students Rigor While Building Agency, Emily Marquise

Masters Theses (Archived)

The purpose of this study is to examine the impact of a social justice approach to mathematics instruction. While many students have math aversion, students in low socioeconomic communities exhibit this to a higher degree putting them at a disadvantage as they progress through their educational career. More than 3.4 million K-12 students in the United States come from families that earn less than the median income yet achieve scores in the top percentile (Wyner et al., 2007). This raises the question of why so many students in low-socioeconomic settings are not given rigorous content that will keep them competitive …

Improving The Quality Of Micronutrient Food Composition Data In Sub-Saharan Africa Using Predictive Analytics, Junior Mbuyamba Muka

Theses and Dissertations

High-quality food composition data are indispensable for decision making in several health, agricultural, and nutrition-related activities. Analytical data are the most accurate type of food composition data (FCD). Yet, most food composition databases (FCDBs) compiled in Sub-Saharan Africa only contain a small amount of analytical data collected from foods consumed in this region. Most of the data are either borrowed / copied from FCDBs collected in other parts of the world, calculated, imputed, or presumed data. Even with these alternative types, FCDBs in Sub-Saharan Africa have not reached a satisfactory level of completeness, as they still have missing data for …

Understanding The Origin, Evolution, And Dynamics Of Transneptunian Binaries, Benjamin C N Proudfoot

Theses and Dissertations

This dissertation discusses research that focuses on understanding transneptunian objects (TNOs) using a variety of techniques and approaches. In Chapter 1, I introduce the main concepts used throughout this dissertation and discuss the current understanding of the transneptunian region. In Chapter 2, I discuss my efforts to understand how Neptune's late stages of migration affect the Haumea family, the only known collisional family in the transneptunian region. Using advanced simulations of Neptune migration, I find that the Haumea family can plausibly form before the termination of giant planet migration and show that this extensively mixes the family. The simplest explanation …

Synthesis And Characterization Of Porphyrin And Phthalocyanine-Based Photosensitizers For Energy And Biomedical Applications, Mavis Forson

Theses and Dissertations

Porphyrins have been widely used as photosensitizers in research due to their important role in many biological processes. Phthalocyanines have also gained interest in biological applications such as photodynamic therapy (PDT). This dissertation is focused on the synthesis of different photosensitizers for various applications. This dissertation's first section focuses on research involving synthesizing covalently bonded donor-acceptor systems as photosensitizers. Specifically in this work, two porphyrin-fullerene dyads were synthesized using a modified tetraphenyl porphyrin with varying bridges between the porphyrin and fullerene. Metal was incorporated in the porphyrin core to enhance the properties of the dyads as photosensitizers. Detailed photophysical properties, …

Final 2023 Residential Metals Abatement Program (Rmap) Brw/Belgrade Borrow Submittal, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Mitigation Of Impacts To Historic Features At The Butte Reduction Works (Brw) Smelter, Kate Mccourt

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Choosing A Sophisticated, Robust, And Secure Programming Language, J. Simon Richard

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

This paper explores which programming languages maximize the quality and efficiency of software development projects requiring high levels of sophistication, security, and stability. Of the four languages discussed in this paper—C, C++, Java, and Rust—we conclude that Rust is the best for this application.

Lipid Membrane Self-Assembly And Synthesis In The Lab By Rapid, Low-Cost Microfluidics Approaches, Kathleen Hardwick, Shane O'Reilly

SURE Journal: Science Undergraduate Research Experience Journal

Lipid membranes, which self-assemble in nature and under laboratory conditions, can form vesicles called liposomes. The main uses for liposomes are in drug delivery systems and as animal cell models. From the initial research into lipid membrane science, to the systematic literature review using Web of Science, to refining the project scope, to the description of the method, this project follows the process of developing a method for lipid membrane self-assembly and synthesis in the lab. The result was a rapid prototyping method for fabricating microfluidic devices to test different designs for channels, for use with a liposome synthesis protocol. …

Regulation Of Mirnas In Obesity And Diabetes, Eva Maher, Ava O'Meara, Cathy Brougham

SURE Journal: Science Undergraduate Research Experience Journal

Introduction: The prevalence of obesity and obesity-related secondary disorders has increased dramatically in recent years. Dysregulated microRNA (miRNA) expression has been linked to the development of obesity and its associated disorders. Adipose derived stem cells (ADSCs) are promising cell models of obesity, obesity-related inflammation and diabetes. Furthermore, miRNA expression profiles have emerged as promising targets for the novel treatment of diseases such as obesity. In order to enhance miRNA-based therapies, the miRNA expression profile of obesity and its related disorders must be monitored to further understand the underlying mechanisms of obesity and to identify novel targets.

Aim: The aim of …

The Potential Of Stem Cell Therapy In Multiple Sclerosis Treatment: A Review, Sorina Amarculesei, Ava O'Meara Cushen, Cathy Brougham

SURE Journal: Science Undergraduate Research Experience Journal

Multiple Sclerosis is an autoimmune and neurodegenerative disease of the central nervous system. There are currently 2.8 million people living with Multiple Sclerosis worldwide, including 9000 people in Ireland, with a prevalence of 193 per 100,000 people. Symptoms of Multiple Sclerosis include sensory loss, fatigue, cognitive dysfunction, spasticity, depression, optic neuritis, gait ataxia, diplopia, and loss of bladder control. Currently, there is no standardised treatment or cure for Multiple Sclerosis with many strategies focusing on symptoms. Stem cells have emerged as promising approaches for Multiple Sclerosis therapeutics. Clinical trials primarily focus on mesenchymal stem cell-based therapies for Multiple Sclerosis. Furthermore, …

Editorial - Sure Journal Vol 5, Anne M. Friel

SURE Journal: Science Undergraduate Research Experience Journal

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Ungrading: Reflections Through A Feminist Pedagogical Lens, Erin M. Eggleston, Shelby Kimmel

Feminist Pedagogy

Ungrading is a pedagogical approach in which no grades are given on any assignments. Instead, students are provided with many opportunities to submit work and gain feedback. The goal is to shift student focus from achieving a grade to growth as a learner and a person. As instructors, our ungrading approach utilized personalized learning plans, checkpoint reflections, and student-professor learning conferences to put agency in the hands of our students. We employed this method in upper-level biology and computer science courses and provide critical reflections here regarding our experiences and the connections between this approach and feminist STEM pedagogy tenets. …

Centering Equity In Stem Teaching: Stem Ideas That Change The World, Ileana Vasu

Feminist Pedagogy

No discussion on equity/inequity makes sense without bringing power into that discussion. As instructors we need to ask questions such as “who decides and controls what knowledge is”, “whose identities are empowered and whose are erased”, “who has access and opportunity and who doesn’t”. Traditional teaching in STEM, including mathematics, assumes knowledge is objective, transmittable, repeatable to everyone. When educators follow a traditional curriculum, just like their teachers before them, they do so thinking their methods ensure equality and objectivity. These practices not only deny the role that Western patriarchal cultures have played in creating these so-called equitable practices, but …

Building Community, Competency, And Creativity In Calculus 2: Summary Of A Pilot Year Of Project Implementation, Jennifer Beichman, Candice R. Price

Feminist Pedagogy

In light of the COVID-19 pandemic, instructional modes at our institution moved to fully online and remote, then fully online but on campus, and back to in-person learning in fall 2021. To combat perceived issues in student engagement, we piloted using group projects in place of exams at the natural content break points in Calculus 2.

Feminist Pedagogy In Stem: The Intersection Of Stem Pedagogy And Feminist Theory, Lesley-Ann Giddings, Candice R. Price

Feminist Pedagogy

No abstract provided.

Non-Fungible Tokens (Nfts) - Survey Of Current Applications, Evolution And Future Directions, Qaiser Razi, Aryan Devrani, Harshal Abhyankar, Gss Chalapathi, Vikas Hassija, Mohsen Guizani

Machine Learning Faculty Publications

Non-fungible tokens (NFTs) have become an exciting technology that provides a fresh perspective on asset ownership, provenance, and value exchange. NFTs, a blockchain-based technology, are distinct and indivisible cryptographic tokens used to confirm and record the ownership of digital and physical assets in an immutable and transparent way. The fundamental block of NFT is a smart contract built on a blockchain network. This contract contains specific information about the asset it represents, such as its unique identifier, metadata, and ownership details. The information is kept private and tamper-proof due to the decentralized and distributed structure of the blockchain, boosting faith …

Progress Towards The Development Of Asymmetric Conditions For Intramolecular Heteroatom/Dehydro-Diels-Alder Reactions For Synthesizing Furo[3,4-C] Pyranones And Anticancer Podophyllotoxins, Peter Mpaata

Theses and Dissertations

Furo[3,4-c] pyranone is a unique bicyclic molecular structure found in bioactive sesquiterpene isobolivianine and in artificial cytotoxic stilbene derivatives. The structure of furo[3,4-c] pyranone is analogous to cyclopenta[c] pyran structure found in potent cytotoxic iridoids like catapol. Chiral substrates for intramolecular hetero-Diels-Alder (IHDA) reaction have been synthesized in yields ranging from 39% to 81%. These compounds undergo [4+2] cycloaddition via ambimodal/ bispericyclic process to give a mixture of furo[3,4-c] pyranone in yields ranging 40-70% and aryl tetralin lactone derivatives. Density functional theory (DFT) calculations have been performed to gain insight into the mechanism leading to the formation of these compounds. …

Studi Alimentari Italiani E Geologia: Vino E Vulcani Da Diverse Prospettive, Maria Varriale Gomez

Italian Renaissance Foodways

Nel mio progetto di integrazione avanzata, mi impegnerò in un'esplorazione interdisciplinare del vino. Analizzerò il vino utilizzando gli studi alimentari italiani e la geologia, concentrandomi in particolare sugli effetti che i vulcani hanno avuto sul vino in Italia sin dal Medioevo e dal Rinascimento. Nel corso della storia, il vino è stato una parte cruciale della cultura italiana e i vulcani del paese hanno influenzato la produzione della bevanda in modi diversi come la varietà delle uve coltivate e il suo sapore basato sulla composizione del terreno vulcanico. Le numerose regioni in Italia producono vino diverso in gran parte a …

Local Atomic And Magnetic Structure Of Multiferroic (Sr,Ba)(Mn,Ti)O3, Braedon Jones

Theses and Dissertations

We present a detailed study of the local atomic and magnetic structure of the type-I multiferroic perovskite system (Sr,Ba)(Mn,Ti)O3 using x-ray and neutron pair distribution function (PDF) analysis, polarized neutron scattering, and muon spin relaxation (μSR) techniques. The atomic PDF analysis reveals widespread nanoscale tetragonal distortions of the crystal structure even in the paraelectric phase with average cubic symmetry, corresponding to incipient ferroelectricity in the local structure. Magnetic PDF analysis, polarized neutron scattering, and μSR likewise confirm the presence of short-range antiferromagnetic correlations in the paramagnetic state, which grow in magnitude as the temperature approaches the magnetic transition. We show …

Mechanical Characterization Of Vertically Aligned Carbon Nanotube Forest Microelectrodes For Neural Interfacing, Spencer Mcleod Roberts

Theses and Dissertations

Silicon intracortical microelectrodes arrays (MEA) provide some of the best performance for brain computer interfaces but suffer from lifetime limitations that prevent clinical adoption. A primary contributor of lifetime limitations is the chronic foreign body response (FBR) which remains active in response to the brain tissue strain caused by implanted probes during brain micromotion. Designing probes with softer materials can reduce the chronic FBR and improve device lifetime. A high-aspect ratio CNT MEA could provide several advantages as an intracortical MEA but has yet to be mechanically characterized. CNT MEAs are infiltrated with 3 degrees of carbon infiltration and mechanically …

Limit Distributions Of Products Of Independent And Identically Distributed Random 2 × 2 Stochastic Matrices: A Treatment With The Reciprocal Of The Golden Ratio, Santanu Chakraborty

School of Mathematical & Statistical Sciences Faculty Publications

Consider a sequence (Xn)n≥1 of i.i.d. 2×2 stochastic matrices with each Xn distributed as μ. This μ is described as follows. Let (Cn,Dn)T denote the first column of Xn and for a given real r with 012 is very challenging. Considering the extreme nontriviality of this case, we stick to a very special such r, namely, r=√5−12 (the reciprocal of the golden ratio), briefly mention the challenges in this nontrivial case, and completely identify λ for a very special situation.

Lesion Detection In Women Breast’S Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using Deep Learning, Sudarshan Saikia, Tapas Si, Darpan Deb, Kangkana Bora, Saurav Mallik, Ujjwal Maulik, Zhongming Zhao

Faculty, Staff and Student Publications

Breast cancer is one of the most common cancers in women and the second foremost cause of cancer death in women after lung cancer. Recent technological advances in breast cancer treatment offer hope to millions of women in the world. Segmentation of the breast's Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is one of the necessary tasks in the diagnosis and detection of breast cancer. Currently, a popular deep learning model, U-Net is extensively used in biomedical image segmentation. This article aims to advance the state of the art and conduct a more in-depth analysis with a focus on the use …

Investigating The Geochemical Trends At The Sediment-Water Interface Of The Shallow And Eutrophic Utah Lake, Abidemi Sherif Aremu

Theses and Dissertations

The sources of phosphorus (P) in Utah Lake can be diverse, including natural and anthropogenic point and non-point sources, such as atmospheric deposition, soil erosion, and industrial and urban wastewater effluents. This study collected interface sediments, column water, porewater, and sediment cores across this vast water body. These samples were then analyzed for their mineralogic, organic, and elemental composition to characterize the geochemical nature of water and sediment at the water-sediment interface within Utah Lake. The average concentrations of P and other elements found in the column water of an individual site do not significantly differ across depth suggesting Utah …