Physical Sciences and Mathematics Commons^™

Investigation Of Warfarin–Human Serum Albumin Binding By Ultrafast Affinity Extraction Using Single- And Dual-Column Affinity Microcolumn Systems, Samiul Alim

Department of Chemistry: Dissertations, Theses, and Student Research

This dissertation examined the interaction of warfarin with human serum albumin (HSA) by using affinity chromatography, with particular emphasis on ultrafast affinity extraction (UAE) and affinity microcolumns. HSA affinity supports were prepared by immobilizing HSA onto diol-bonded silica via Schiff base chemistry and used to prepare affinity microcolumns for chromatographic studies under physiological-like conditions at pH 7.4 and 37.0 °C. UAE studies were performed to investigate the effects of residence time, flow rate, and column configuration on the measured apparent free fraction of warfarin and on the calculated apparent binding parameters. The results showed that the measured apparent free fraction …

Public Acceptance Of Meat-Reduction Policies Across Cultures: Comparing Singapore And Switzerland, Bianca Wassmann, Shu Tian Ng, Mark Chong, Angela K. Y. Leung, Michael Siegrist

Research Collection Lee Kong Chian School Of Business

Purpose – As meat-reduction policies are discussed across the globe, many are met with public resistance. Cultural values may help explain this pushback, yet their role in shaping support for food policy remains poorly understood. This study is the first to apply cultural cognition theory to food policy by examining how cultural worldviews shape the acceptance of meat-reduction interventions in Singapore and Switzerland—two economically developed countries with contrasting cultural profiles. Design/methodology/approach – In an online survey, participants (Singapore: n = 357; Switzerland: n = 495) rated their acceptance of 11 meat-reduction interventions (e.g. taxes, subsidies, labelling). We then analysed to …

Cloud Tank: Virtual Reality Performance Instrument For Embodied Audiovisual Remixing, Asya Ulger

Computer Science Senior Theses

Traditionally, live audiovisual performances are made behind a desk using a laptop and an audio controller. This setup restricts the performer’s movements and separates the artist from their work. Moreover, it narrows what counts as the performance to the output alone — the audience is preconditioned to treat the projected image and sound as the whole event, and not the artist producing it. Cloud Tank challenges this by positioning the performer’s body as the instrument, using virtual reality. As the performer, I mix spatialized audio and drive beat-aligned, reactive video layers through hand movement and hand-pose recognition. The audiovisual output …

Hydpn: A Hybrid Deep Reinforcement Learning, Programming, And Neighborhood Operations Framework For Integrated Scheduling On Parallel Batch Processing Machines, Yuqi Wang, He Luo, Guoqiang Wang, Zhaoxia Wang

Research Collection School Of Computing and Information Systems

Batch processing machines (BPMs) are widely used in industries such as semiconductors, metal processing, and healthcare, where jobs are processed in batches. As production, inventory, and distribution become increasingly integrated to improve efficiency, research on their joint scheduling in parallel BPM environments remains scarce. This paper addresses the integrated scheduling problem in parallel BPMs, involving production, inventory, and distribution stages, with the objective of minimizing total costs. A unified cost-based model is first formulated, applicable to both in-facility and external distribution scenarios. A hybrid algorithm framework, HyDPN, combining deep reinforcement learning, dynamic programming, and neighborhood operations is proposed. Extensive experiments …

Extensive And Intensive Margin Labor Supply On Ride-Sourcing Platforms, Hao Sun, Hai Wang, Zhixi Wan

Research Collection School Of Computing and Information Systems

The rapid expansion of ride-sourcing platforms has enabled freelance drivers to flexibly determine both their participation and working hours. Understanding this flexible labor supply behavior is essential for managing platform capacity and evaluating the impacts of pricing and incentive policies on driver welfare. This study develops a labor supply model in which drivers optimally choose whether to participate (extensive margin) and how long to work (intensive margin) to maximize their utility from consumption and leisure. The model incorporates heterogeneity in drivers’ other income, idle time, and participation costs, allowing us to analytically characterize equilibrium labor supply decisions. The results show …

Benchmarking Gaslighting Negation Attacks Against Multimodal Large Language Models, Bin Zhu, Yinxuan Gui, Huiyan Qi, Jingjing Chen, Chong-Wah Ngo, Ee-Peng Lim

Research Collection School Of Computing and Information Systems

Multimodal Large Language Models (MLLMs) have exhibited remarkable advancements in integrating different modalities, excelling in complex understanding and generation tasks. Despite their success, MLLMs remain vulnerable to conversational adversarial inputs. In this paper, we systematically study gaslighting negation attacks—a phenomenon where models, despite initially providing correct answers, are persuaded by user-provided negations to reverse their outputs, often fabricating justifications. We conduct extensive evaluations of state-of-the-art MLLMs across diverse benchmarks and observe substantial performance drops when negation is introduced. Notably, we introduce the first benchmark GaslightingBench, specifically designed to evaluate the vulnerability of MLLMs to negation arguments. GaslightingBench consists of multiple-choice …

The Stars Align: Modeling User Rating Calibration With Sparse Semantic Review Features, Rodrigo Alves, Antoine Ledent

Research Collection School Of Computing and Information Systems

User ratings are often treated as comparable across users, although identical scores may reflect different experiences. We study whether ratings can be viewed as user-specific discretizations of a shared semantic continuum derived from review text. Our method maps reviews into sparse semantic features with a sparse autoencoder and learns user-specific filters for each rating level. On Amazon Electronics, the learned embeddings align along a shared low-dimensional rating axis. Users differ mainly in how they anchor and partition this continuum, while preserving its overall ordinal structure. These findings support a semantic view of calibration beyond scalar bias correction.

Not Too Early, Not All At Once: Design Tensions In Ai-Mediated Self-Disclosure In Online Dating, Pei-Hua Tsai, Tianyi Zhang, Emran Bin Elias Poh, Anthony Tang, Yung-Ju Chang

Research Collection School Of Computing and Information Systems

Online dating relies on self-disclosure, yet initial conversations are fragile: users must navigate uncertainty around timing, boundaries, and reciprocity with little shared context. While advances in AI raise the possibility of mediating disclosure, how such support might reshape the experience of early-stage relational disclosure remains underexplored. We conducted 29 semi-structured interviews to examine how daters envision AI-mediated self-disclosure in online dating. Our findings surface recurring design tensions rather than simple opportunities or risks. Participants welcomed guidance that could pace disclosure, support reflection, and reduce social awkwardness, but stressed preserving agency and authorship. They valued interpretive assistance for sense-making of ambiguous …

Language Embeddings Meet Shallow Autoencoders, Rodrigo Alves, Vojtěch Vančura, Pavel Kordík, Antoine Ledent

Research Collection School Of Computing and Information Systems

Shallow autoencoders are appealing recommenders due to their simplicity, scalability, and competitive retrieval quality, but they struggle in strict cold-start settings where new items have no interactions. We propose an inductive shallow autoencoder that leverages item side information (language embeddings) by fixing the decoder to item features and learning only an encoder in the same semantic space. To prevent trivial self-reconstruction without enforcing a hard zero diagonal, we introduce diagonal gating: a leave-one-item-out objective that blocks the self-copy shortcut only for the item being updated while retaining context from the rest of the user history. An alternating-style optimization trains the …

Vehicle-Based Multi-Services For Future Smart Cities, Hao Sun, Jinhua Zhao, Hai Yang, Shenhao Wang, Hamsa Balakrishnan, Thomas W. Malone, Hai Wang

Research Collection School Of Computing and Information Systems

Vehicles are crucial for sustaining socioeconomic activity and improving quality of life in modern cities by offering diverse services. These include passenger mobility, goods delivery, information acquisition, and acting as mobile servers such as food trucks and mobile lockers. At the same time, they also contribute to traffic congestion and air pollution. This tension fosters the rise of urban resource-conserving and sustainable service solutions. In this article, we introduce the concept of “Vehicle-Based Multi-Services” (VeMuS), in which a single vehicle offers multiple services simultaneously. Drawing on practical use cases, we examine service classification and integration for vehicles and the potential …

Rc-Nf: Robot-Conditioned Normalizing Flow For Real-Time Anomaly Detection In Robotic Manipulation, Shijie Zhou, Bin Zhu, Jiarui Yang, Xiangyu Zhao, Jingjing Chen, Yu-Gang Jiang

Research Collection School Of Computing and Information Systems

Recent advances in Vision-Language-Action (VLA) models have enabled robots to execute increasingly complex tasks. However, VLA models trained through imitation learning struggle to operate reliably in dynamic environments and often fail under Out-of-Distribution (OOD) conditions. To address this issue, we propose Robot-Conditioned Normalizing Flow(RC-NF), a real-time monitoring model for robotic anomaly detection and intervention that ensures the robot's state and the object's motion trajectory align with the task. RC-NF decouples the processing of task-aware robot and object states within the normalizing flow. It requires only positive samples for unsupervised training and calculates accurate robotic anomaly scores during inference through the …

Anatomical Domain Shifts: Test-Time Heterogeneous Adaptation For 3d Human Pose Prediction, Qiongjie Cui, Pan Zhou, Jingjing Chen, Na Zhao

Research Collection School Of Computing and Information Systems

The research frontier in human pose prediction (HPP) is advancing toward continual test-time adaptation (TTA), where models must self-adapt to dynamic test distributions. To date, the homeostatic continual TTA remains the sole viable solution, which isolates the model parameters and update domain-sensitive ones. Despite mitigating full-body domain gaps, human anatomical heterogeneity (domain shifts often localize to specific regions) is ignored. This anatomical-agnostic approach forces uniform parameter adaptation across kinematically distinct segments, causing: over-adaptation of stable regions and under-adaptation of shift-prone articulations. To address it, we introduce TT-HA, a novel Test-Time Heterogeneous Adaptation that implicitly estimates domain changes for anatomical segments, …

Ai In Healthcare: Regulatory Guidelines And Judge-Made Negligence Principles For Ai Implementers, Gary K. Y. Chan

Research Collection Yong Pung How School Of Law

The use of artificial intelligence (AI) in healthcare may, notwithstanding its potential benefits, result in harm to patients from allegedly negligent acts or omissions by hospitals and medical doctors. In such circumstances, how should the principles in the tort of negligence (duty of care, breach, causation, remoteness of damage, and defences) respond to AI innovations in healthcare? In particular, how may the standard of care expected of hospitals and medical doctors be informed by regulatory guidelines? We refer to case law precedents and regulatory guidelines on the roles and responsibilities of doctors and hospitals as AI implementers. Importantly, they prompt …

Pso-Style Social Influence In An Ant Colony Algorithm For Continuous-Domain Optimization, Ashraf M. Abdelbar, Donald C. Wunsch

Electrical and Computer Engineering Faculty Research & Creative Works

ACOR is a well-established Ant Colony Optimization (ACO) algorithm for continuous-domain optimization. In this paper, we propose an extension (which we call ACOR∗) in which several fundamental modifications are made to ACOR's solution construction process, including the incorporation of a social influence mechanism borrowed from Particle Swarm Optimization (PSO). Our modifications to the ACOR algorithm are intended to promote search diversity and combat premature convergence. We experimentally evaluate our proposal in the context of training feedforward neural networks for classification using 65 widely used datasets from the University of California Irvine (UCI) repository, as well as the optimization of several …

Draft Final 2023 Unreclaimed Sites Sampling: Ur-31 Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Draft Final 2022 Unreclaimed Sites Sampling: Ur-27 Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Draft Final Quarterly Operations And Maintenance Report: Butte Treatment Lagoon System – First Quarter 2026, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Draft Final 2022 Unreclaimed Sites Sampling: Ur-07 Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Final Quarterly Operations And Maintenance Report: Butte Treatment Lagoon System – Fourth Quarter 2025, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The Security Of Llm-Generated Code, Christopher Brian Gonzalez Ayala

Student Theses

The rapid adoption of Large Language Models (LLMs) in software development has transformed coding practices by enabling automated code generation, completion, and optimization. Despite these advantages, concerns persist regarding the security and reliability of LLM-generated code. This study presents a comprehensive evaluation of both the functional correctness and security of code produced by three prominent LLMs as of early 2026. A total of 4,800 code snippets were generated using 100 security-focused programming prompts derived from the OWASP Top 10:2025, translated across eight natural languages and two phrasing styles (literal and natural developer-oriented prompts). To assess performance, a multi-stage experimental framework …

Forensic Analysis Of Temporary Tattoo Markers And Inks, Daniel J. G. Chasse Jr

Student Theses

As tattoos rise in popularity, some marker manufacturers have created temporary tattoo markers so that children and adults can experience tattoos without the permanence of a regular tattoo. These new products are marketed explicitly as ‘temporary tattoo markers’ and intended for direct application to the skin. This research aims to scientifically evaluate the inks from these temporary tattoo markers to elucidate their physical and chemical properties using wet chemistry, visual examination, ultraviolet-visible spectroscopy (UV/Vis), Fourier-transform infrared spectroscopy (FT-IR), attenuated total reflectance infrared spectroscopy (ATR-IR), thin layer chromatography (TLC), and diffuse reflectance infrared spectroscopy (DRIFTS) to analyze temporary tattoo markers and …

Adversarial Robustness Of Perceptual Hashing Systems: A Unified Security Evaluation Framework, Avijit Roy

Student Theses

Social network platforms, child safety organizations, and image provenance systems use perceptual hashing to identify known child sexual abuse material (CSAM), support content moderation and reverse image search, and verify image integrity. Perceptual hashing works by producing similar fingerprints for visually similar images, even after common transformations such as compression, resizing, or minor brightness changes. This useful similarity-preserving property also creates an adversarial attack surface, as attackers can use AI-assisted or conventional image manipulation techniques to move a hash across a matching threshold while maintaining visual similarity, often without access to specialized hardware.

The security failures produced by adversarial attacks …

The Comparative Chemical Analysis Of Colored Henna, Vani D. Bhagwandeen

Student Theses

Henna, a natural dye derived from Lawsonia inermis, is widely used for temporary body art, hair coloring, and cultural decorative practices such as Mehendi. Traditional henna produces a reddish-brown stain through lawsone, a naphthoquinone chromophore that binds to keratin in skin, hair, and nails (Badoni Semwal et al., 2014; de Groot, 2013; Kumar Singh et al., 2015). Commercial henna products have increasingly incorporated synthetic dyes, pigments, and glitter additives to produce a broader range of colors and effects (Blair et al., 2004; Manso et al., 2017; Blackledge & Jones, 2007). Despite their prevalence, limited forensic research has examined the …

Investigating The Detection Ability Of Presumptive Bloodstain Testing Through Concealment Obstacles, Skye E. Lehr

Student Theses

Bloodstain detection can provide valuable information on the ability of presumptive tests. When perpetrators seek to alter the scene of violent crimes to interfere with investigations or flee from justice, crime scene investigation becomes more complex. In this analysis, scenarios where bloodstain evidence is attempted to be removed by household cleaners and covered up by acrylic or oil-based paint, are tested using luminol and Kastle-Meyer direct testing. These bloodstains have been altered by bleach, dish soap or all-purpose cleaner and covered under multiple layers of acrylic or oil-based paint. Evidence is documented both photographically and visually to simulate crime scene …

Quantum And Conventional Informatics Studies Of Synthesis Energetics And Defect Formation In Nitride Crystal Epitaxy, Andrew Steven Messecar

Dissertations

Machine learning is a valuable approach for the processing and analysis of complex information. By estimating relationships from recorded data, machine learning methodologies can be effective strategies for pattern recognition, enabling investigations and technological applications based thereon. The potential for improved understanding of high-dimensional data has drawn interest towards machine learning from across the sciences, including the research and development of new and improved material systems. In the context of experimental materials research, much of the reported efforts to incorporate machine learning into conventional practice have been primarily focused on either the enhanced analysis of characterization experiment data or the …

When Saying "No" Is Not Enough: Cognitive-Action Decoupling And The Illusion Of Safety In Llm Agents, Shasha Yu

School of Professional Studies

Current safety evaluations of large language models (LLMs) predominantly rely on textual compliance, implicitly assuming that refusal-style responses correspond to safe behavior. This assumption becomes fragile when LLMs are embedded in agentic systems with the ability to execute state-changing actions. In this paper, we present an empirical critique of text-centric safety evaluation through an action-aware study of LLM agents under controlled conditions. Across multiple state-of-the-art models, we observe a recurring cognitive-action decoupling: agents generate policy-aligned refusal language while still producing unsafe tool-mediated action proposals. This produces an illusion of safety, where conversational audits indicate compliance even as operational risk persists. …

On-The-Fly Generation-Quality Enhancement Of Deep Code Models Via Model Collaboration, Weifeng Sun, Naiqi Huang, Meng Yan, Zhongxin Liu, Hongyan Li, Yan Lei, David Lo

Research Collection School Of Computing and Information Systems

The growing prominence of deep code models in automating software engineering tasks is undeniable. However, their deployment encounters significant challenges in on-the-fly performance enhancement, which refers to dynamically improving the performance of deep code models during real-time execution. Conventional techniques, such as retraining or fine-tuning, are effective in controlled pre-deployment scenarios but fall short when adapting to on-the-fly adjustments post-deployment. CodeDenoise, a notable on-the-fly performance enhancement technology, leverages uncertainty-based methods to identify misclassified inputs and applies an input modification strategy to rectify classification errors. While effective for classification tasks, this approach is inapplicable to generative tasks due to two key …

Interfold: Learning Interpretable Diffusion Manifolds Beyond Binary Samples, Alexander Vincent Lewi, Rainer Tan, Shengfeng He

Research Collection School Of Computing and Information Systems

We propose InterFold, a framework for learning and applying interpretable semantic manifolds in latent diffusion models, without requiring binary or paired supervision. Existing methods for semantic editing either rely on limited paired data or uncover only coarse, unsupervised directions that fail to capture user-specific, fine-grained attributes. InterFold addresses these limitations by learning a target attribute manifold in the H-space of diffusion models using only a set of positive, unlabeled examples. To edit a new image, InterFold projects its H-space representation toward this learned manifold through test-time optimization, enabling precise, identity-preserving modifications of complex, non-binary concepts. To make these edits effective …

Trace: Temporal Rhetorical Analysis And Consistency Evaluation For Legislative Speech, David Hernandez

Master's Theses

Legislators frequently discuss the same policy issues across multiple hearings and legislative sessions, sometimes maintaining consistent positions and other times modifying or reframing their stance over time. Understanding how these positions evolve is important for analyzing political discourse and democratic accountability, yet identifying such shifts at scale remains difficult.

We introduce TRACE (Temporal Rhetorical Analysis and Consistency Evaluation), a system built on the Digital Democracy Database (DDDB) for detecting rhetorical inconsistency in California legislative hearing testimony. TRACE organizes utterances into speaker-anchored timelines indexed by bill and session, then applies hybrid semantic retrieval — combining dense BGE embeddings with BM25 lexical …

Computational Insights Into Nucleosome Dynamics In Epigenetics Using Molecular Dynamics Simulations, Rutika Patel

Dissertations, Theses, and Capstone Projects

Nucleosome core particles (NCP) are the building blocks that form a highly organized and compact chromatin structure. Nucleosomes package DNA in the nucleus of eukaryotic cells. The NCP consists of about 147 base pairs of DNA wrapped around the histone octamer, with 1.65 superhelical turns in a left-handed manner. The histone octamer is composed of two copies of H3, H4, H2A, and H2B. Together with histone H1 and linker DNA, they further assemble into a higher-order chromatin structure. The nucleosome complex is stabilized by electrostatic interactions between positively charged histone residues and the negatively charged DNA backbone. To effectively access …