Physical Sciences and Mathematics Commons^™

Prospective Use Of Detection Dogs As A Screening Tool For Mycoplasma Ovipneumoniae In Bighorn Sheep (Ovis Canadensis), Michele C. Lovara

Electronic Theses and Dissertations

Mycoplasma ovipneumoniae is a bacterium that can spill over from domestic sheep (Ovis aries) to bighorn sheep (Ovis canadensis), with effects in bighorn sheep ranging from low to no lamb recruitment to whole-herd all-age die-offs from resulting pneumonia. Fast and reliable pathogen or disease detection is essential for managing outbreaks in bighorn sheep and emergences in affected populations. Detection dogs are increasingly being enlisted to close gaps and further complement various disease, pathogen and virus research and response efforts. This thesis explores the use of conservation detection dogs as a potential tool for M. ovipneumoniae surveillance in bighorn sheep through …

Shifting Waters: A 41-Year Time-Series Analysis Of Surface Water Change In The Prairie Pothole Region, Madison Dejarlais

Electronic Theses and Dissertations

The Prairie Pothole Region (PRR) is a landscape defined by a dynamic surface water system, with wetlands, lakes, and rivers playing critical roles in supporting biodiversity, regulating floods, and maintaining hydrological balance. This study conducts a time-series analysis of surface water change in the PPR from 1984 to 2024, using remote sensing tools including Google Earth Engine, ArcGIS Pro, and ENVI. 41 annual surface water presence rasters were compiled into a cumulative dataset, allowing for both year-to-year comparisons and broader trend analysis. Results indicate that the presence of surface water in the PPR has not followed a simple linear trend. …

Frobenius And Commutative Pseudomonoids In The Bicategory Of Spans, Ivan Contreras, Rajan Amit Mehta, Walker H. Stern

Mathematics Sciences: Faculty Publications

In previous work by the first two authors, Frobenius and commutative algebra objects in the category of spans of sets were characterized in terms of simplicial sets satisfying certain properties. In this paper, we find a similar characterization for the analogous coherent structures in the bicategory of spans of sets. We show that commutative and Frobenius pseudomonoids in Span correspond, respectively, to paracyclic sets and Γ-sets satisfying the 2-Segal conditions. These results connect closely with work of the third author on A∞ algebras in ∞-categories of spans, as well as the growing body of work on higher Segal objects. Because …

Quantification Of Changes With Combined Shape Mode Analysis And Swimming Simulations, Kelli E. Gutierrez, Becca Thomases, Paulo E. Arratia, Robert D. Guy

Mathematics Sciences: Faculty Publications

Many different microswimmers propel themselves using flagella that beat periodically. The shape of the flagellar beat and swimming speed have been observed to change with fluid rheology. We quantify changes in the flagellar waveforms of Chlamydomonas reinhardtii in response to changes in fluid viscosity using (i) shape mode analysis and (ii) a full swimmer simulation to analyse how shape changes affect the swimming speed and to explore the dimensionality of the shape space. By decomposing the gait into the time‑independent mean shape and the time‑varying stroke, we find that the flagellar mean shape substantially changes in response to viscosity, while …

Characterizations Of Stability Via Morse Limit Sets, Jacob D. Garcia

Mathematics Sciences: Faculty Publications

Subgroup stability is a strong notion of quasiconvexity that generalizes convex cocompactness in a variety of settings. In this paper, we characterize stability of a subgroup by properties of its limit set on the Morse boundary. Given H < G, both finitely generated, H is stable exactly when all the limit points of H are conical, or equivalently when all the limit points of H are horospherical, as long as the limit set of H is a compact subset of the Morse boundary for G We also demonstrate an application of these results in the settings of the mapping class …

Topological Symmetry Groups Of The Generalized Petersen Graphs, Angelynn Álvarez, Erica Flapan, Mark Hunnell, John Hutchens, Emille Lawrence, Paul Lewis, Candice Price, Ruth Vanderpool

Mathematics Sciences: Faculty Publications

The topological symmetry group TSG(Γ) of an embedded graph Γ in S³ is the subgroup of the automorphism group of the graph which is induced by homeomorphisms of (S³,Γ). If we restrict to orientation-preserving homeomorphisms then we obtain the orientation-preserving topological symmetry group TSG₊(Γ). In this paper, we determine all groups that can beTSG(Γ) or TSG₊(Γ) for some embedding Γ of a generalized Petersen graph other than the exceptional graphs P(12,5) and P(24,5).

Circadian Variation In Mgmt Promoter Methylation And Expression Predicts Sensitivity To Temozolomide In Glioblastoma, Maria F. Gonzalez-Aponte, Yitong Huang, William A. Leidig, Tatiana Simon, Omar H. Butt, Marc D. Ruben, Albert H. Kim, Joshua B. Rubin, Erik D. Herzog, Olivia J. Walch

Mathematics Sciences: Faculty Publications

Purpose Recent studies show that glioblastoma (GBM) is more sensitive to temozolomide (TMZ) in the morning. In cells, inhibiting O6-Methylguanine-DNA-Methyltransferase (MGMT) abolished time-dependent TMZ efficacy, suggesting that circadian regulation of this DNA repair enzyme underlies daily TMZ sensitivity. Here, we tested the hypotheses that MGMT promoter methylation and protein abundance vary with time-of-day in GBM, resulting in daily rhythms in TMZ efficacy.

Methods We assessed daily rhythms in MGMT promoter methylation in GBM in vitro and retrospectively analyzed MGMT methylation status in human GBM biopsies collected at different times of day. Next, we measured MGMT and BMAL1 protein …

A Geometric Characterization Of N-Graded Manifolds And The Frobenius Theorem, Henrique Bursztyn, Miquel Cueca, Rajan Amit Mehta

Mathematics Sciences: Faculty Publications

This paper studies graded manifolds with local coordinates concentrated in non-negative degrees. We provide a canonical description of these objects in terms of classical geometric data and, building on this geometric viewpoint, we prove the Frobenius theorem for distributions in this graded setting.

Synthesis And Design Of Clpp Activators As Novel Antibiotics, Schyler Odum

Theses and Dissertations (ETD)

Purpose. Design and synthesize novel compounds to treat Staphylococcus aureus infections by targeting the dysregulation of the Casein Protease P, ClpP. Methods. Utilize established chemical methods to synthesize ureadepsipeptides, small-molecule ClpP activators, and ureadepsipeptide hybrids. Assess their effectiveness by using minimum inhibitory concentration assays and in vitro biochemical assays for ClpP activation. Explore their potential as antibiotics through mitochondrial toxicity tests, glucose/galactose assays, and biophysical measurements related to metabolism and clearance, including thermal shift and surface plasmon resonance assays. Results. Synthesized and tested 33 novel compounds, comprising a total of 80 synthetic steps. Conclusion. The three-part conclusion from the dissertation …

Numerical Analysis And The Deal.Ii Implementation Of An Efficient And Robust Parameterized Ensemble Algorithm For Navier Stokes Flow In The Convection-Dominated Regimes, Brandiece Berry

All ETDs from UAB

Ensemble methods are widely used to approximate solutions for the Navier-Stokes Equations to account for inherent uncertainties within the system. This work goes about the numerical analysis and efficiency assessment of a fully discretized Ensemble Eddy Viscosity (EEV) model for the incompressible Stochastic Navier-Stokes Equations. The model is efficient due to the use of ensemble methods. Through a single coefficient matrix for $J$ realizations, we reduce computational cost and thereby ensure computational efficiency. It is found that the model is robust with the inclusion of the eddy viscosity term, as an additional uncertainty quantification. Finally, we verify theoretical convergence rates …

Food Insecurity Among Graduate Students At The University Of Alabama At Birmingham, Amy Elizabeth Callahan

All ETDs from UAB

College food insecurity (FI) has grown steadily as a field of research over the past fifteen years. Existing research primarily has demonstrated that FI is a persistent problem with various risk factors and myriad potential impacts on students, though graduate students are largely understudied in favor of undergraduate and aggregated student populations. Given the unique circumstances graduate students face, as well as expected demographic differences such as age and household characteristics, this is a serious gap in the literature. This dissertation aims to investigate graduate student food insecurity in the United States, and particularly at the University of Alabama at …

Elucidating Non-Canonical Interactions Of Mcl1 With The P53 Family Of Tumor Suppressors, Alexus Marie Acton

All ETDs from UAB

Various signaling mechanisms contribute to a cancers cell’s ability to survive through the stressors of tumorigenesis. Canonically, when a cell is exposed to irreversible stress, the induction to apoptosis is regulated by the Bcl-2 family of apoptotic regulators. However, to accommodate for the stressors of tumor progression, many solid tumors over express one of the pro-survival proteins (e.g., BCL2, BCLxL, MCL1) allowing for persistent growth without the induction to cell death. Over the past 10 years, researchers have investigated how over expression of these pro-survival proteins contribute to chemoresistance to standard of care therapies. To sensitize cells to these apoptotic …

Analysis Of Gas Station Drugs Using Gas Chromatography Mass Spectrometry And Fourier Transform Infrared Spectroscopy, Megan Joos

All ETDs from UAB

Gas stations and head shops are a seemingly safe and legal marketplace for drug purchase. However, although marketed as dietary supplements or cognitive enhancers, the products sold there have been known to contain psychoactive substances which may be mislabeled or actually contain regulated substances. This study investigates the composition of such products, specifically those labeled as kratom and non-kratom Mitragyna species using gas chromatography-mass spectrometry (GC-MS) and those labeled as phenibut using GC-MS and fourier transform infrared spectroscopy (FTIR). Samples were acquired from retailers in the Birmingham, AL area. The products underwent both qualitative and quantitative analysis of their ingredients …

Investigating Risk Of Suboptimal Hiv Treatment Outcomes (Treatment Failure And Disengagement) Among Pregnant And Postpartum Women Living With Hiv, Kevin Owuor

All ETDs from UAB

The joint United Nations Programme on HIV/AIDS (UNAIDS) has set targets to end the HIV epidemic by improving HIV diagnosis, treatment, and viral suppression to reduce new infections and improve health outcomes for people living with HIV (PLHIV), including pregnant and postpartum women living with HIV (PPWH). After diagnosis, linking PPWH to antiretroviral (ART) treatment is critical to suppress the virus and prevent mother-to-child transmission (MTCT) of HIV. Continuous engagement in care is essential for achieving and maintaining virologic suppression in the peripartum and postpartum period for PPWH, both for their own health and the health of their family. Disengagement …

Radioactive Seed Localization For The Resection Of Nonpalpable Breast Lesions, Katherine Ward

All ETDs from UAB

Accurate localization of malignant tissues is critical in breast cancer treatment to ensure effective therapy while minimizing damage to surrounding healthy tissues. Radioactive seed localization, specifically using Iodine-125 (I-125), is a prominent method due to its precision and minimally invasive nature. However, this technique poses a risk of radiation exposure to adjacent healthy tissues. This study aims to quantify the radiation dose to healthy breast tissue from I-125 seed implantation by employing two distinct computational approaches: a hemisphere breast model in MATLAB and Monte Carlo simulations in Mathematica. The American Association of Physicists in Medicine (AAPM) Task Group 43 (TG- …

Doping Hybrid Photopolymerisable Glass With Bodipy Photosensitiser: An Efficient Approach To Improve Uv-Resistance, Luca Sorridente, Tatsiana Mikulchyk, Metodej Dvoracek, Mikhail A. Filatov, Izabela Naydenova, Kevin P. Murphy

Conference Papers

The development of photosensitive materials with improved performance and extended functionality is crucial for advancing holographic technologies. This study presents the modification and characterization of a recently reported photopolymerisable glass composition, focusing on achieving an optimal balance between maximizing photosensitivity of the material during recording and minimizing the impact of UV light on the performance of the recorded holographic structure. Building on these findings, the ultimate goal is to develop UV-resistant holographic optical elements for wavefront sensing in space applications. The research approach is based on introducing a photosensitiser with weaker UV absorption than the typically used in this material …

Insects, Ai Systems, And The Future Of Legal Personhood, Jeff Sebo

Animal Law Review

This Article makes a case for insect and AI legal personhood. Humans share the world not only with large animals like chimpanzees and elephants but also with small animals like ants and bees. In the future, we might also share the world with sentient or otherwise morally significant AI systems. These realities raise questions about what kind of legal status insects, AI systems, and other nonhumans should have in the future. At present, debates about legal personhood mostly exclude these kinds of individuals. However, I argue that our current framework for assessing legal personhood, coupled with our current framework for …

Synthesizing Deception: Countering Large Language Model-Generated Phishing Campaigns Through Adaptive Semantic Anomaly Detection, Bekim Fetaji, Debabrata Samanta

Mesopotamian Journal of Computer Science

The paper fills in a gap in the literature that demonstrates an insufficient number of sturdy detection schemes that can recognize the small semantic aberrations inherent in LLM-generated deceptive text. Our proposed co-design hybrid model is Semantic Anomaly Detection with Isolation Forest (SADI) model that combines the synergistic mixture of a fine-tuned transformer-based LLM for deep semantic feature extraction with Isolation Forest algorithm that detects anomalies efficiently. This study introduces SADI, an adaptive semantic-anomaly detector for large-language-model phishing emails. Using a corpus of 10 000 messages, SADI attains an F1 score of 0.981 (95 % CI 0.978–0.984) and processes a …

Automated Video Colorization Techniques For Enhanced Visual Realism And Computational Efficiency, Zahoor M. Aydam, Nidhal K. El Abbadi

Mesopotamian Journal of Computer Science

Automatic video colorization remains a challenging computer vision task, particularly when ensuring semantic accuracy and temporal coherence across dynamic, multi-scene content. Existing methods often rely on a single fixed reference image, which fails to adapt to abrupt scene changes or variations in lighting and texture. This study presents a hybrid deep learning framework that dynamically selects multiple reference images per scene using adaptive thresholds derived from the Structural Similarity Index Measure (SSIM) and deep features extracted via a ResNet50 backbone with Generalized Mean Pooling (GeM). The framework integrates three specialized modules pre-processing, reference image processing, and attention-based colorization—operating in the …

Bioaccumulation Of Legacy And Novel Pfas In The Environment, Hesham Taher, Rainer Lohmann

Graduate School of Oceanography Faculty Publications

The bioaccumulation of per- and polyfluoroalkyl substances (PFAS), both legacy and novel, in the environment presents significant ecological and health risks. PFAS are a diverse group of synthetic chemicals known for their persistence and bioaccumulation, which can cause widespread environmental contamination and health risks. Strong carbon-fluorine bonds give these compounds unparalleled stability, preventing them from degrading and enabling them to endure in a range of environmental matrices, including water, soil, and biota. Legacy PFAS, including perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), have been extensively studied and regulated, resulting in lower concentrations in some environmental media. However, novel PFAS, …

Corporate ‘Capture Strategies’ Impacting Human And Ecosystem Health, Alex T. Ford, Marlene Ågerstrand, Michael G. Bertram, Miriam L. Diamond, Rainer Lohmann, Andreas Schäffer, Martin Scheringer, Gabriel Sigmund, Anna Soehl, Maria Clara V.M. Starling, Noriyuki Suzuki, Marta Venier, Penny Vlahos

Graduate School of Oceanography Faculty Publications

The concept of regulatory capture has been extensively studied in academic literature, primarily within the social sciences. This phenomenon has been increasingly discussed in the environmental sciences as the impacts of regulatory capture on human and ecosystem health have become increasingly apparent. Regulatory capture is just one tactic employed by vested interests in the strategy of delaying, weakening, or abolishing policies designed to protect the public interest. Here, we define capture strategies as ‘the act of influencing individuals, organizations, or governments to prioritize corporate interests over those of human and ecosystem health’. Similar to the evolution of terms like whitewashing …

A Biogeochemical Perspective On Acidification And Buffering Capacity In The Piscataqua Estuary, Sanjana Varanasi

Master's Theses and Capstones

Coastal acidification is influenced not only by rising atmospheric CO2 and river-ocean mixing, but also by metabolic processes that alter seawater carbonate chemistry and buffering capacity. This study examines how sedimentary biogeochemical processes contribute to carbonate system variability in the Piscataqua Estuary, a tidally dynamic channel connecting Great Bay to the Gulf of Maine. The biogeochemical processes considered include sedimentary aerobic respiration, denitrification, sulfate reduction, and carbonate dissolution or precipitation. Two incubation experiments were conducted in September and October of 2024 at the University of New Hampshire’s Coastal Marine Laboratory (CML) to quantify changes in pH, dissolved inorganic carbon (DIC), …

Is It Getting Better? An Evaluation Of Two Successive Generations Of Chatgpt In Answering Specialized Vascular Surgery Questions, Dongjin Suh, Quang Le, Leana Dogbe, Kedar Lavingia, Michael Amendola

Department Surgery Faculty Publications

Purpose: Large language models (LLMs) can generate clinically relevant text; however, their performance in highly specialized medical domains remains uncertain. This study evaluated ChatGPT-3.5 and ChatGPT-4 (OpenAI) using vascular surgery board–style questions from the Vascular Education and Self-Assessment Program, version 4 (VESAP4) and compared the two public model versions (June and November 2023).

Materials and Methods: All non-image VESAP4 questions (n=384) were presented independently three times to each model version (ChatGPT-3.5 June/November; ChatGPT-4, June/November). Outcomes included accuracy (proportion correct), consistency (same option letter across all three attempts and “consistently correct”), explanation length (word count), and modes of failure classified for …

The Petrology And Geochemistry Of The Montagna Grande-Monte Gibele Trachytic Shield Volcano (Pantelleria, Italy)., John C. White, Ray Macdonald, Pierangelo Romano, Boguslaw Baginski, Silvio G. Rotolo, Beata Marciniak-Maliszewska, Alessandra Cinquegrani

EKU Faculty and Staff Scholarship

The 45.7 ± 1.0 ka (2σ) eruption of the compositionally zoned (comenditic trachyte to pantellerite) Green Tuff ignimbrite on the volcanic island of Pantelleria, Italy, was followed by the extrusion of a series of post-caldera metaluminous to mildly peralkaline trachyte lavas between 26.2 ± 2.0 and 22.3 ± 2.9 ka (2σ). This study uses whole-rock major- and trace-element compositions, mineral compositions, geothermobarometry, and petrogenetic models to examine the role of trachytes in the evolution of the Pantelleria magma system. Although previous studies have suggested that all of these units are consanguineous and form a liquid line of descent (LLOD) from …

Separation And Surface Examination Of Spacecraft Cabin Particulates, Grace A. Belancik

Master's Theses

Particulate matter in the atmosphere is a known detriment to human health, but several factors affect any particulate’s particular toxicity including particle size, surface area, and chemical composition. Extensive studies have been conducted to examine particulate hazards on Earth, but in crewed spacecraft, like the International Space Station (ISS), the particulate environment is wholly unique due to both the controlled environment and lack of gravity. Atmospheric sampling studies are underway, but another convenient source of airborne particulates for analysis is the contents of the vacuum bags used by the astronauts to clean the air vents. However, no method currently exists …

Episodes In Computing History - Salon Talk, George K. Thiruvathukal

Computer Science: Faculty Publications and Other Works

This talk (first given in 2004) presents a concise overview of key developments in the history of computing. It begins with early methods of counting and recordkeeping, such as tally sticks and the Inca quipu. It then traces the evolution of numeric systems, including Roman and Hindu-Arabic notation, and the mathematical contributions of figures like Al-Khwarizmi. Mechanical computing devices such as the abacus, Napier’s bones, and the Pascaline are examined, along with the Jacquard loom and its use of punch cards.

The talk continues through the rise of electronic computing, highlighting milestones such as ENIAC, the work of Alan Turing, …

Generalizing Classification Of Pilot Workload: Transfer Learning Versus A Jepa-Inspired Transformer Architecture, Naim Barnett, Shivani Nagrecha, Morgan Glover, Clayton Harper, Justin Wilson, James Maher, Eric C. Larson

International Journal of Aviation, Aeronautics, and Aerospace

Within the context of learning, there poses difficulty when objectively measuring human performance. In this work, we investigate the evaluation of human performance via its relation to the individual's mental capacity by classification of cognitive load within the domain of aviation. By utilizing a mixed virtual and physical flight simulation environment in conjunction with biometric sensing, we create and evaluate the predictive capabilities of a Joint-Embedding Predictive Architecture (JEPA) and compare the architecture and results to traditional methods for transfer learning and domain adaptation. We find that our JEPA inspired architecture can achieve more than 70% accuracy of cognitive workload, …

Advances In Ocean Mapping And Nautical Cartography, Giuseppe Masetti, Ian Church, Anand Hiroji, Ove Andersen

Center for Coastal and Ocean Mapping

The Special Issue of Geomatics on "Advances in Ocean Mapping and Nautical Cartography" addresses emerging methodologies, technologies, and applications in ocean mapping. This collection includes studies on the development of high-resolution seabed mapping techniques, innovative data processing for marine cartography, and advancements in hydrographic surveying. It highlights the importance of integrating geospatial data from sources such as remote sensing, autonomous underwater vehicles, and satellite-based observations. Additionally, articles discuss challenges and strategies for ensuring data accuracy and accessibility, reflecting a growing interest in sustainable marine resource management and navigation safety enhancements.

Unh/Noaa Joint Hydrographic Center 2025 Performance And Progress Report Executive Summary, Larry A. Mayer

Center for Coastal and Ocean Mapping

No abstract provided.

Calcium Carbonate Microparticles As Acid Responsive Targeted Drug Delivery Carriers For Oral Diseases And Its Anti-Bacterial Activity, Hem Raj Joshi

Dissertations and Theses

Dental diseases are mostly caused by bacterial infections in the teeth, forming biofilms that release acids and decay the enamel of the teeth. More than half of the world's population were affected by oral diseases, including periodontitis (gum disease), dental caries (cavities), and oral cancer. Chlorhexidine (CHX) is the mostly used antimicrobial drug for dental diseases, but its overexposure to the healthy teeth causes many side effects, such as tooth staining, taste alteration, and many more. Taking advantage of the acidic environment of infected teeth, we designed a pH responsive targeted drug delivery system using calcium carbonate microparticles (CCMPs) as …