Physical Sciences and Mathematics Commons^™

Modelling Uncertain Volatility Using Quantum Stochastic Calculus: Unitary Vs Non-Unitary Time Evolution, Will Hicks

Journal of Stochastic Analysis

No abstract provided.

Analysis And Description Of The Iridescent Film On Calcites In Eastern Iowa, Cavit Schempp, John Oostenryk

Geology: Student Scholarship & Creative Works

During the Devonian Period, eastern to central Iowa experienced multiple transgressive and regressive intervals. This study focuses on the Cou Falls and Gizzard Creek Members of the Coralville Formation, deposited during the Eifelian Stage. Sometime after the formation of the limestone, the interiors of various brachiopods, gastropods, and other fauna began to weather out, creating vugs within the limestone, which gave rise to the first of three growth phases of calcite in the form of rhombohedrons and scalenohedrons. After these primary calcites were formed, new fluids flowed through these vugs, depositing a previously misidentified iridescent film on the calcite crystals, …

Impact Of Arctic And Antarctic Sudden Stratospheric Warmings On Thermospheric Composition, Jiarong Zhang, Jens Oberheide, Nicholas M. Pedatella, Guiping Liu

All Physics Faculty Publications

Using the Global‐scale Observations of the Limb and Disk (GOLD) and the Global Ultraviolet Imager (GUVI), we examine the impact of sudden stratospheric warmings (SSWs) on the changes of thermospheric composition during the 2018–2019 and 2020–2021 Arctic SSWs and the 2019 Antarctic SSW. Contributions of planetary waves, gravity waves, and migrating tides are assessed by performing numerical experiments with the NSF National Center for Atmospheric Research (NCAR) vertically extended version of the Whole Atmosphere Community Climate Model (WACCM‐X). The variations in the column integrated O and N2 density ratio (∑ O/N₂) are generally similar among WACCM‐X, GOLD, …

Voltage-Gated Sodium Channel Nav1.7 Subtype: A Promising Therapeutic Target For Metastatic Medullary Thyroid Cancer, Piyasuda Pukkanasut

All ETDs from UAB

Medullary thyroid carcinoma (MTC), a rare neuroendocrine tumor, presents considerable clinical challenges due to its tendency to metastasize to organs such as the liver, bones, and brain, resulting in poor patient outcomes. Voltage-gated sodium channels (VGSCs) have emerged as potential therapeutic targets in various malignancies due to their crucial role in promoting cancer cell progression, migration, invasion, and metastasis. This dissertation investigates the specific contributions of the VGSC NaV1.7 subtype in MTC, evaluating its potential as a therapeutic target and elucidating its mechanistic involvement in MTC. Initially, we assessed VGSC subtypes expression in MTC cells. The screening revealed an overexpression …

Development Of Momordica Saponin-Based Vaccine Adjuvants, Hyunjung Kim

All ETDs from UAB

Vaccine adjuvants are indispensable substances that help induce a fast, potent, and durable immune response when administered with vaccine antigens. Among the FDA-approved vaccine adjuvants for human use, three of the most recently approved ones contain saponin adjuvant QS-21. To address QS-21’s inherent drawbacks, we investigated the adjuvant activity of a series of saponin-based semisynthetic vaccine adjuvants, including VSA-1 and VSA-2, prepared from natural Momordica saponins I and II in one-step. The natural saponins precursors are isolated from the widely available and inexpensive seeds of Momordica cochinchinensis SPRENG. In general, VSA adjuvants can enhance both humoral and cellular immune responses …

Targeting Streptococcus Mutans Diadenylate Cyclase For The Prevention Of Dental Caries, Edwin Miguel Rojas

All ETDs from UAB

Streptococcus mutans (S. mutans) is the primary etiological agent involved in the initiation and progression of dental caries. S. mutans forms robust biofilms on the tooth surface, and current preventative treatments, such as oral rinses, eliminate both pathogenic and commensal oral species. Therefore, there is an urgent need for therapeutics which selectively inhibit S. mutans biofilms while keeping the oral microbiome intact. The diadenylate cyclase (DAC) enzyme in S. mutans plays a key role in biofilm formation. DAC converts adenosine triphosphate (ATP) into cyclic di-AMP (c-di-AMP), a secondary messenger involved in several cellular pathways. Increased levels of c-di-AMP have shown …

New Frontiers In Synthesis Of High-Entropy Materials Enabled By Microwave-Induced Plasma, Bria Christina Storr

All ETDs from UAB

This dissertation presents the novel approach for synthesizing high entropy borides (HEBs) and high entropy alloys (HEAs) using microwave-induced plasma as a rapid and efficient processing tool. High entropy materials (HEMs) have peaked interested in recent years due to their unique properties and practical applications such as thermal stability, and corrosion and wear resistance. HEMs are designed by combining multiple principal elements in near-equimolar ratios, enhancing stability, and offering a broad spectrum of tailored mechanical properties. The inclusion of multiple transition metals within these structures increases hardness and oxidation resistance, and the flexibility in element selection enables precise tuning for …

Key Degradation Mechanisms Of Perovskite Solar Cells And Strategies For Enhanced Stability: Issues And Prospects, Md Helal Miah, Md Bulu Rahman, Mohammad Nur-E-Alam, Mohammad Aminul Islam, M. Shahinuzzaman, Md Rezaur Rahman, Md Habib Ullah, Mayeen Uddin Khandaker

Research outputs 2022 to 2026

Perovskite materials have garnered significant attention within a very short period of time by achieving competitive efficiency. In addition, this material demonstrated intriguing optoelectronic properties and versatile applications. Although they have confirmed amazing efficiency in solar cells at the laboratory scale, mass commercial manufacturing of perovskite solar cells (PSCs) is still a problem due to their poor longevity. Researchers have identified several intrinsic and extrinsic factors contributing to the instability of perovskite compounds and PSCs, and various approaches are being used to increase material quality and stability in order to extend the lifespan of PSCs. Despite these challenges, the potential …

Synthesis And Characterization Of Bimetallic Plasmonic Nanoparticles Using Linear And Nonlinear Spectroscopy, Daniel Babayode

LSU Doctoral Dissertations

Recent exploration in the field of nanomaterials has led to the investigation of noble metal nanoparticles for various nanomedical applications. The spectroscopy of these nanoparticles is studied using both linear and nonlinear optical processes such as second harmonic generation (SHG), two-photon fluorescence (TPF), and extinction spectroscopy. Details pertaining to the growth dynamics of silver-gold core-shell (Ag@Au CS) nanoparticles (NPs) and gold-silver-gold core-shell-shell (Au@Ag@Au CSS) nanoparticles (NPs) are currently being investigated in order to obtain better control and optimization of the nanoparticle size and surface morphology. Transmission electron microscopy (TEM) images show that the nanoparticles have tunable core and shell sizes …

Evaluation Of Green Tea Yoghurt Enriched With Lacticaseibacillus Paracasei E1 Microcapsules On Macrophage M1 Profile In High Fat-Fructose Diet Mice, Esha Ardiansyah, Nur Alfi Maghfirotus Sa’Adah, Rahmi Izati, Belinda Nabiila Al Faizah, Dawama Nur Fadlilah, Septhyanti Aprilia Kavitarna, Mochammad Fitri Atho’Illah, Siti Nur Arifah, Yoga Dwi Jatmiko, Muhaimin Rifa’I

Karbala International Journal of Modern Science

Obesity is caused by an energy imbalance that increases chronic low-grade inflammation, including macrophage cell infiltration. Adipose tissue macrophages are polarized into pro-inflammatory macrophage type 1 (M1), secrete large amounts of pro-inflammatory cytokines, and activate transcription factors. Yoghurt with probiotics is popular at all ages for its health benefits and must be protected by microencapsulation. Green tea (Camellia sinensis L.) fortification provides yoghurt nutrients while improving its functional qualities and bioactivity. This study aimed to evaluate the effect of microencapsulation of Lacticaseibacillus paracasei E1 in green tea yoghurt (GTY) on the profile of M1 macrophages in mice fed a …

The Nanograv 15 Yr Data Set: Running Of The Spectral Index, Gabriella Agazie, Akash Anumarlapudi, Anne M. Archibald, Zaven Arzoumanian, Jeremy G. Baier, Paul T. Baker, Bence Bécsy, Laura Blecha, Adam Brazier, Paul R. Brook, Sarah Burke-Spolaor, J. Andrew Casey-Clyde, Maria Charisi, Shami Chatterjee, Tyler Cohen, James M. Cordes, Neil J. Cornish, Fronefield Crawford, H. Thankful Cromartie, Kathryn Crowter, Megan E. Decesar

Pacific Faculty Work

The NANOGrav 15 yr data provide compelling evidence for a stochastic gravitational-wave (GW) background at nanohertz frequencies. The simplest model-independent approach to characterizing the frequency spectrum of this signal consists of a simple power-law fit involving two parameters: an amplitude A and a spectral index γ. In this Letter, we consider the next logical step beyond this minimal spectral model, allowing for a running (i.e., logarithmic frequency dependence) of the spectral index, grun (f ) = g + b ln (f /fref ). We fit this running-power-law (RPL) model to the NANOGrav 15 yr data and perform a Bayesian model …

Restoring The AhupuaʻA: Community-Based Resource Management And Resilience In KauaʻI, Jeffrey W. Walbridge Jr.

Environmental Studies Senior Theses

This thesis analyzes Kauaʻi’s evolving resource management practices, examining the intersections of historical governance frameworks, modern legal systems, and indigenous knowledge. Utilizing the traditional ahupuaʻa system, Kauaʻi’s approach once promoted holistic stewardship across water, land, and energy resources. However, colonial policies, corporate influence, and economic pressures have gradually shifted this framework toward a market-driven model, often prioritizing tourism and development over ecological resilience. Key policy shifts as they fight to return to an ahupua'a based model – from the Great Mahele’s introduction of private land ownership to water diversions for plantation agriculture – help examine how these changes continue to …

Stability Of Lif Mirror Coatings On Space Telescopes At L2 Orbit, Devin M. Lewis

Theses and Dissertations

A team at Goddard Space Flight center has developed a coating of aluminum mirrors they term XeLiF. This coating has high ultraviolet reflection and improved environmental stability over similar LiF coatings. For these reasons, it is a potential candidate for the future Habitable Worlds Observatory (HWO) flagship space telescope mission. However, the stability of XeLiF at the planned L2 orbit of HWO has not been investigated. This study highlights the potential damage to XeLiF when irradiated by electrons that will be present at L2. This radiation will begin removing LiF after 6 years of exposure as well as start roughening …

Can Trichoderma Spp. Contribute To The Bioremediation And Biostimulation Of Plants In Soil Contaminated With Herbicides?, Elaine Damiani Conte, Elton José Da Rosa, Gabriel Rieth Silvestrini, Daiane Da Silva Motta, Christiane Fernandes De Oliveira, Carine Cocco, Gabriel Fernandes Pauletti, Taísa Dal Magro, Joséli Schwambach

School of Earth, Environmental, & Marine Sciences Faculty Publications

This work aimed to evaluate the potential of Trichoderma spp. in the bioremediation of herbicides and biostimulation of plants in herbicide-contaminated soils. In the first phase, the experiment followed a completely randomized design in a 4 × 3 × 4 factorial scheme with five replications, four strains of Trichoderma spp., three herbicides, and four herbicide doses. The mycelial growth speed index (MGSI) of Trichoderma spp. was obtained by growing it in a Petri dish with PDA associated with different doses of herbicides and evaluated every 24 h for 10 days. Results indicated the selection ofTrichoderma harzianumT1A to continue …

Production And Radiochemistry Of Theranostic Radioscandium Nuclides, Shelbie Jaylene Cingoranelli

All ETDs from UAB

In nuclear medicine, theranostics utilizes radionuclide pairs for diagnosis and therapy. Radioscandium isotopes (43Sc, 44Sc, and 47Sc) offer a promising alternative to the 68Ga/177Lu theranostic pair due to their identical radiolabeling conditions, complexes and in vivo pharmacokinetics. 43Sc (t1/2=3.89h, β+=88%) and 44Sc (t1/2 =3.97h. β+=94.3%) are suitable for Positron Emission Tomography (PET) imaging whereas 47Sc (t1/2=3.3d. Eβ-ave=162keV) is suitable for targeted radiotherapy and Single Photon Emission Computed Tomography (SPECT). These isotopes require production routes that lead to high radionuclidic purity and radiochemistry development for incorporation into radiopharmaceuticals. This study explores the production, purification, and application of these isotopes. The proton …

Elucidating The Role Of The Secondary Coordination Sphere In Tuning Reactivity Of Synthetic Heme Superoxide Complexes And Other Biologically Relevant Intermediates, Garrett B. Tolbert

All ETDs from UAB

Tryptophan catabolizing human heme-dioxyganase enzymes have been linked to a multitude of disease conditions; therefore, understanding the mechanistic details of their function is of great interest to facilitate the design of effective inhibitors for therapeutic applications. Synthetic model systems have demonstrated dioxygenation of indole moieties, elucidating key mechanistic details of the overall reaction. However, the contrastingly low reactivity of the synthetic heme-superoxide intermediates compared to those of dioxygenase enzymes necessitates the revaluation of these models with direct relevance to their biological mode of action. Herein, we report detailed mechanistic studies on the reactivity of model porphyrin systems with installed non-covalent …

Autoethnographic Action Research As A Contemplative Practice: Awareness And Transformation Of Inner And Outer Selves, Jiju Varghese, Bal Chandra Luitel, Niroj Dahal

The Qualitative Report

Contemplation as a spiritual practice has taken various forms across different religious traditions and regions worldwide. Over the years, various contemplative practices have evolved and become popular even outside religious traditions to promote the well-being of all for inner and outer selves’ transformation. In education, many scholars worldwide have expounded on the benefits of contemplative practices in the classroom for students and teachers. Contemplative practices have penetrated research practices in the form of contemplative inquiry considering performative, philosophical, and artistic transformations, where researchers enter into a deep, thoughtful, and reflective introspective journey to see the connection between what is seen …

Scproatlas: An Atlas Of Multiplexed Single-Cell Spatial Proteomics Imaging In Human Tissues, Xi Liu, Pora Kim, Liyu Huang, Kexin Huang, Xiaobo Zhou

Faculty, Staff and Student Publications

Spatial proteomics can visualize and quantify protein expression profiles within tissues at single-cell resolution. Although spatial proteomics can only detect a limited number of proteins compared to spatial transcriptomics, it provides comprehensive spatial information with single-cell resolution. By studying the spatial distribution of cells, we can clearly obtain the spatial context within tissues at multiple scales. Spatial context includes the spatial composition of cell types, the distribution of functional structures, and the spatial communication between functional regions, all of which are crucial for the patterns of cellular distribution. Here, we constructed a comprehensive spatial proteomics functional annotation knowledgebase, scProAtlas (https://relab.xidian.edu.cn/scProAtlas/#/), …

Aspdb: An Integrative Knowledgebase Of Human Protein Isoforms From Experimental And Ai-Predicted Structures, Rongbin Li, Wenbo Chen, Chiamaka S Diala, Meer A Ali, Yi Xu, Albon Wu, Sayed-Rzgar Hosseini, Erfei Bi, Hongyu Zhao, Pora Kim, W Jim Zheng

Faculty, Staff and Student Publications

Alternative splicing is a crucial cellular process in eukaryotes, enabling the generation of multiple protein isoforms with diverse functions from a single gene. To better understand the impact of alternative splicing on protein structures, protein-protein interaction and human diseases, we developed ASpdb (https://biodataai.uth.edu/ASpdb/), a comprehensive database integrating experimentally determined structures and AlphaFold 2-predicted models for human protein isoforms. ASpdb includes over 3400 canonical isoforms, each represented by both experimentally resolved and predicted structures, and >7200 alternative isoforms with AlphaFold 2 predictions. In addition to detailed splicing events, 3D structures, sequence variations and functional annotations, ASpdb uniquely offers comparative analyses and …

Metsdb: A Knowledgebase Of Cancer Metastasis At Bulk, Single-Cell And Spatial Levels, Zhaocan Zhang, Zhennan Lu, Pora Kim, Xiaobo Zhou, Liyu Huang

Faculty, Staff and Student Publications

Cancer metastasis, the process by which tumour cells migrate and colonize distant organs from a primary site, is responsible for the majority of cancer-related deaths. Understanding the cellular and molecular mechanisms underlying this complex process is essential for developing effective metastasis prevention and therapy strategies. To this end, we systematically analysed 1786 bulk tissue samples from 13 cancer types, 988 463 single cells from 17 cancer types, and 40 252 spots from 45 spatial slides across 10 cancer types. The results of these analyses are compiled in the metsDB database, accessible at https://relab.xidian.edu.cn/metsDB/. This database provides insights into alterations in …

Crisprofft: Comprehensive Database Of Crispr/Cas Off-Targets, Pora Kim, Qianqian Song, Xiaona Liu, Xiaobo Zhou

Faculty, Staff and Student Publications

The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-associated protein) programmable nuclease system continues to evolve, with in vivo therapeutic gene editing increasingly applied in clinical settings. However, off-target effects remain a significant challenge, hindering its broader clinical application. To enhance the development of gene-editing therapies and the accuracy of prediction algorithms, we developed CRISPRoffT (https://ccsm.uth.edu/CRISPRoffT/). Users can access a comprehensive repository of off-target regions predicted and validated by a diverse range of technologies across various cell lines, Cas enzyme variants, engineered sgRNAs (single guide RNAs) and CRISPR editing systems. CRISPRoffT integrates results of off-target analysis from 74 studies, encompassing …

Infografía: El Nexo De Unión Entre Ciencia Y Diseño Gráfico, Ángel Serrano Valverde, Almudena Torres Pardo

GDI. Revista de investigación de Género, Diseño e Innovación

En la divulgación científica, tanto en la que se realiza en congresos de alto impacto y nivel académico, como en la que encontramos en los museos, en los libros de texto o en las redes sociales, se están utilizando infografías. Principalmente, para explicar procesos complejos y sucesos no observables sin el uso de instrumentación específica, o no reproducibles con sencillez.

Este artículo investiga esa relación entre ciencia y diseño a través de la infografía, recorriendo la historia de la infografía científica y su uso en los diferentes ámbitos divulgativos actuales.

Desde un punto de vista científico y de diseño, analizaremos …

Constructing A Metadata Knowledge Graph As An Atlas For Demystifying Ai Pipeline Optimization, Revathy Venkataramanan, Aalap Tripathy, Tarun Kumar, Sergey Serebryakov, Annmary Justine, Arpit Shah, Suparna Bhattacharya, Martin Foltin, Paola Faraboschi, Kaushik Roy, Amit P. Sheth

Faculty Publications

The emergence of advanced artificial intelligence (AI) models has driven the development of frameworks and approaches that focus on automating model training and hyperparameter tuning of end-to-end AI pipelines. However, other crucial stages of these pipelines such as dataset selection, feature engineering, and model optimization for deployment have received less attention. Improving efficiency of end-to-end AI pipelines requires metadata of past executions of AI pipelines and all their stages. Regenerating metadata history by re-executing existing AI pipelines is computationally challenging and impractical. To address this issue, we propose to source AI pipeline metadata from open-source platforms such as Papers-with-Code, OpenML, …

Elastomeric Nanocomposite With Solvent-Free, One Step, In Situ Shear Exfoliation Of Graphite To Graphene, Ashiqur Rahman, Md Abdur Rahman Bin Abdus Salam, Matthew G. Boebinger, Ahmed Touhami, Jennifer Lynch, Ali Ashraf

Physics & Astronomy Faculty Publications

A graphene nanoflake (GNF)-enhanced elastomeric nanocomposite (G-EMC) is fabricated following an innovative, cost-effective, single-step, in situ shear exfoliation (ISE) method from low-cost bulk material, graphite, where uniform mixing happens simultaneously within the elastomer matrix. Electron microscopy, atomic force microscopy, and photo-induced force microscopy results show good dispersion of GNFs with exfoliation to a few layers and uniform distribution in the elastomer matrix. X-ray photoelectron spectroscopy analysis shows less than 1% oxygen-containing functional groups/impurity, enhanced bonding through the formation of edge sites as fracture occurs across the GNF basal plane, and pi-pi interactions with newly exfoliated planar basal plane surfaces of …

Ur-213 Generative Ai & Cybersecurity, Seth G Canada, Shreya Katare

C-Day Computing Showcase

This research project details the impact of Generative AI on Cybersecurity through both its potential enhancements and threats. Using advanced AI algorithms, this project explores how Generative AI can strengthen cybersecurity through systems like Anomaly Detection, Intrusion Detection Systems (IDS), and Malware Analysis. Also, this project addresses the growing challenges posed from Generative AI. In particular, issues surrounding Deepfake Phishing and Polymorphic Malware are discussed. Solutions to mitigate these issues are also provided to engage further understanding in the field. The goal of this research is to offer practical solutions for addressing the growing field of AI-driven cybersecurity.

An Attempt To Determine The Strong Tremors Causes During Longwall Mining Of Destressed Bottom Layer Of A Thick Coal Seam, Rafał Pakosz, Łukasz Wojtecki, Maciej J. Mendecki, Agnieszka Krzyżanowska

Journal of Sustainable Mining

The sequence and method of coal seam mining can significantly minimize the risk of rock bursts. The planning of exploitation in the Bielszowice part of the Ruda Hard Coal Mine involves maximizing the destress effect associated with the mining of adjacent coal seams or layers of thick coal seams. Longwall mining of destressed coal seams is characterized by much lower seismic activity; however, even during such mining, high-energy tremors may occur. This article analyzes the seismic activity accompanying the mining of longwall panels in the bottom and top layers of thick seam No. 510 and seam No. 507 in the …

Collision-Free Exploration By Mobile Agents Using Pebbles, Sajal K. Das, Amit Kumar Dhar, Barun Gorain, Madhuri Mahawar

Computer Science Faculty Research & Creative Works

In this paper, we study collision-free graph exploration in an anonymous network. The network is modeled as a graph G = (V, E) where the nodes of the graph are unlabeled, and each edge incident to a node v has a unique label, called the port number, in {0, 1, ⋯, d - 1}, where d is the degree of the node v. Two identical mobile agents, starting from different nodes in G have to explore the nodes of G in such a way that for every node v in G, at least one mobile agent visits v and no …

Smevca: Stable Matching-Based Ev Charging Assignment In Subscription-Based Models, Arindam Khanda, Anurag Satpathy, Anusha Vangala, Sajal K. Das

Computer Science Faculty Research & Creative Works

The rapid shift from internal combustion engine vehicles to battery-powered electric vehicles (EVs) presents considerable challenges, such as limited charging points (CPs), unpredictable wait times for charging, and difficulty in selecting appropriate CPs for EVs. To address these challenges, we propose a novel end-to-end framework, called Stable Matching based EV Charging Assignment (SMEVCA) that efficiently assigns charge-seeking EVs to CPs with the assistance of roadside units (RSUs). The proposed framework operates within a subscription-based model, ensuring that the subscribed EVs complete their charging within a predefined time limit enforced by a service level agreement (SLA). The framework SMEVCA employs a …

Adaptive Workload Management For Enhanced Function Performance In Serverless Computing, Priyanka Ashok Birajdar, V. Harsha, Anurag Satpathy, Sourav Kanti Addya

Computer Science Faculty Research & Creative Works

Serverless computing streamlines application deployment by removing the need for infrastructure management, but fluctuating workloads make resource allocation challenging. To solve this, we propose an adaptive workload manager that intelligently balances workloads, optimizes resource use, and adapts to changes with auto-scaling, ensuring efficient and reliable serverless performance. Preliminary experiments demonstrate an ≈ 0.6X% and 2X% improvement in execution time and resource utilization compared to the First-Come-First Serve (FCFS) scheduling algorithm.

A Second Candidate Magnetic Helium Core White Dwarf And 3 Other Variable White Dwarfs In The Globular Cluster Ngc 6397, Manuel Pichardo Marcano, Liliana E. Rivera Sandoval, Thomas J. Maccarone, Rene D. Rohrmann, Leandro G. Althaus, Craig O. Heinke, Diogo Belloni, Arash Bahramian

Physics & Astronomy Faculty Publications

Using archival Hubble Space Telescope observations, we report the discovery of four variable low-mass white dwarfs (WDs; 0.18 M⊙ ≤ M ≤ 0.5 M⊙) in the globular cluster NGC 6397. One source exhibits a periodic optical modulation of 5.21 ± 0.02 hr, which we interpret as potentially due to the rotation of a magnetic helium core WD (He WD). This makes this candidate the second magnetic He WD in NGC 6397, and one of the few He WDs with a measured rotation period. The other three candidates show aperiodic variability, with a change in magnitude ranging from ∼0.11 …