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Full-Text Articles in Physical Sciences and Mathematics

Draft Final 2022 Unreclaimed Sites Sampling: Ur-28 Site Evaluation Summary Report, Pioneer Technical Services, Inc. Apr 2025

Draft Final 2022 Unreclaimed Sites Sampling: Ur-28 Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

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Examining The Effects Of Symbiotic State And Environmental Pollution On Wound Healing In Coral, Jonathan De Montagnac Apr 2025

Examining The Effects Of Symbiotic State And Environmental Pollution On Wound Healing In Coral, Jonathan De Montagnac

College Honors Program

Understanding coral reef health requires comprehension of the biological processes that support live coral cover. Corals are frequently exposed to physical abrasion from various sources, thereby necessitating vital resources be directed towards wound recovery. For corals and other organisms that harbor photosynthetic symbionts, the balance between autotrophic versus heterotrophic energy contributions influences their fitness. Experimentally disentangling the individual effects of environmental stress and symbiotic state on coral health is difficult in most tropical corals due to the obligate nature of their symbiosis. However, determining how nutritional dynamics, environmental stressors, and health interact is crucial to understanding coral resilience. To examine …

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Environmental Risk And Alpha-Gal Syndrome (Ags) In The Mid-Atlantic United States, Brandon D. Hollingsworth Ph.D., Margaret Wiener, Dana A. Giandimenico, Scott P. Commins, Ross M. Boyce Apr 2025

Environmental Risk And Alpha-Gal Syndrome (Ags) In The Mid-Atlantic United States, Brandon D. Hollingsworth Ph.D., Margaret Wiener, Dana A. Giandimenico, Scott P. Commins, Ross M. Boyce

Faculty Publications

Alpha-gal syndrome (AGS), commonly referred to as the tick bite red meat allergy, has been reported worldwide with the number of suspected cases in the United States increasing from 24 in 2009 to over 34,000 in 2019. Within the US, AGS is associated with the bite of two tick species, Amblyomma americanum and Ixodes scapularis, and has particularly high incidence rates in the mid-Atlantic region. Because AGS is associated with tick bites, the risk of developing AGS is affected by the environment individuals visit. Despite this, as well as the numerous studies associating the environment with Am. americanum, …

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Quadratic Stochastic Processes: Algebraic Structures And Their Applications, Taimun Qaisar Apr 2025

Quadratic Stochastic Processes: Algebraic Structures And Their Applications, Taimun Qaisar

Thesis/ Dissertation Defenses

This research focuses on the algebraic structures of the Quadratic Stochastic Processes (QSPs). In this work, we first study 𝜉(𝑎)- Quadratic Stochastic Operators (QSOs) linked to the partition ℙ3. We simultaneously discuss the dynamics of the obtained QSOs. Moreover, the algebraic structure of the associated genetic algebra is studied. Further, we build Quadratic Stochastic Processes (QSPs) using the given Markov processes. Consequently, we obtain an ordinary differential equation for the resultant Quadratic Stochastic Processes (QSPs). Besides, we apply the solution of this ordinary differential equation to the option pricing problem. Thereafter, we construct Quadratic Stochastic Processes …

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Solar Parking, Glen Welch, K.C. Green, Catie Bean, Makenzie Keith, Connor Patterson Apr 2025

Solar Parking, Glen Welch, K.C. Green, Catie Bean, Makenzie Keith, Connor Patterson

Earth Day Symposium on Climate and Sustainablity

No abstract provided.

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Energy Efficient Dorms, Antonio Soares, Zachary Nassar, Aidan O'Neill Apr 2025

Energy Efficient Dorms, Antonio Soares, Zachary Nassar, Aidan O'Neill

Earth Day Symposium on Climate and Sustainablity

No abstract provided.

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Reducing Energy Consumption At Bryant University, Joey Madan, Jake Chernin, Brandon Kemp Apr 2025

Reducing Energy Consumption At Bryant University, Joey Madan, Jake Chernin, Brandon Kemp

Earth Day Symposium on Climate and Sustainablity

No abstract provided.

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Dry Paths, Safe Steps, Andrew Gamper Apr 2025

Dry Paths, Safe Steps, Andrew Gamper

Earth Day Symposium on Climate and Sustainablity

No abstract provided.

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Developing An Unfolding-Incorporated Coarse-Grained Polymer Model For Fibrinogen To Study The Mechanical Behaviour, Vivek Sharma, Poulomi Sadhukhan Apr 2025

Developing An Unfolding-Incorporated Coarse-Grained Polymer Model For Fibrinogen To Study The Mechanical Behaviour, Vivek Sharma, Poulomi Sadhukhan

Northeast Journal of Complex Systems (NEJCS)

Fibrinogen is a protein found in blood that forms Fibrin polymer network to build a clot during wound healing process when there is a cut in the blood vessel. The fibrin fiber is highly stretchable and shows a complex mechanical properties. The fibrin monomer, Fibrinogen, has a very complex structure which is responsible for its unusual elastic behaviour. In this work, we focus on mechanism of unfolding of D-domain of Fibrinogen, and study its effect in the mechanical behaviour. We develop a coarse-grained (CG) bead-spring model for Fibrinogen which captures the unfolding of folded D-domains along with other necessary structural …

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Expanding The Horizons Of Nonagonal Neutrosophic Numbers As A Versatile Framework For Decision-Making And Scientific Applications In Covid-19, Muhammad Naveed Jafar, Kainat Muniba, Hamiden Abd El-Wahed Khalifa, Fahd Jarad Apr 2025

Expanding The Horizons Of Nonagonal Neutrosophic Numbers As A Versatile Framework For Decision-Making And Scientific Applications In Covid-19, Muhammad Naveed Jafar, Kainat Muniba, Hamiden Abd El-Wahed Khalifa, Fahd Jarad

Neutrosophic Systems with Applications

In this article, the concept of nonagonal neutrosophic numbers has been introducing in the disjunctive frame of reference. We also proposed the dependency and independency of membership function in regards to nonagonal neutrosophic number. We also introduce a new score function and its computation also formulated in a distinct rational viewpoint. We developed the concept of weighted arithmetic averaging operator and weighted geometric averaging operator for nonagonal neutrosophic numbers. It will open new doors for MCDM and develop the concept with new approaches. Additionally, we analyze the effect of COVID-19 for different ages.

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An Approach To Model Uncertainty In Fluid Behaviour With Navier-Stokes Equations In Neutrosophic Environment, Muhammad Saeed, Attia Hameed, Neha Andaleeb Khalid, Muhammad Salman Habib Apr 2025

An Approach To Model Uncertainty In Fluid Behaviour With Navier-Stokes Equations In Neutrosophic Environment, Muhammad Saeed, Attia Hameed, Neha Andaleeb Khalid, Muhammad Salman Habib

Neutrosophic Systems with Applications

The complex discipline of fluid dynamics examines the behavior of fluids and their interactions with adjacent objects. The Navier-Stokes equations are very important for explaining how fluids move, but they are not linear and often give answers that depend on the starting point and the boundaries. Modeling fluid behavior is challenging due to the inherently chaotic and unpredictable character of fluid dynamics. To deal with unknown or uncertain values in this research, we used neutrosophic logic to look at the Navier-Stokes equations in a new way. Neosophic logic permits the existence of values that are partially true and partially false; …

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Leveraging Hypersoft Set To Optimize Livestock In The Era Of Unmanned Aerial Vehicles, Alaa Salem, Mona Mohamed, Nebojsa Bacanin, Mohamed Abouhawwash Apr 2025

Leveraging Hypersoft Set To Optimize Livestock In The Era Of Unmanned Aerial Vehicles, Alaa Salem, Mona Mohamed, Nebojsa Bacanin, Mohamed Abouhawwash

Neutrosophic Systems with Applications

Due to urbanization and industrialization, rapid global change and the potential loss of arable land, agricultural output must rise in production levels and harvest, distribute, and use resources more efficiently. It is believed that using technology on livestock would help meet the expanding population's demand for food. Internet of Things (IoT) and Unmanned Aerial Vehicle (UAV) integration in conventional farming has transformed operations, providing farmers with greater productivity, improved decision-making, and sustainability. We assume that there are enough UAVs to cover the entire pasture, and our goal is to identify the best UAVs. Accordingly, determining the best type of UAVs …

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A Novel Neutrosophic Decision-Making Approach For Optimizing Metaverse Headphone Design: Balancing Technical Performance And User Emotional Needs, Mai Mohamed, Amira Salam, Karam Sallam, Bilal Arain Apr 2025

A Novel Neutrosophic Decision-Making Approach For Optimizing Metaverse Headphone Design: Balancing Technical Performance And User Emotional Needs, Mai Mohamed, Amira Salam, Karam Sallam, Bilal Arain

Neutrosophic Systems with Applications

The concept of the metaverse, which combines various technologies to create a wide range of virtual experiences, has gained significant popularity in recent years. To fully engage in these metaverse environments, users rely on access devices such as virtual reality (VR) headsets and smartphones for augmented reality (AR). These devices must be lightweight, compact, and user-friendly to ensure comfort and enhance customer satisfaction. There is a growing focus on innovating and designing products that not only meet technical requirements but also address the emotional needs of users, ultimately improving the overall experience. Selecting the ideal design for Metaverse headphones is …

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Nash Equilibrium Solutions For Continuous Static Games Under Neutrosophic Environment, M. G. Brikaa Apr 2025

Nash Equilibrium Solutions For Continuous Static Games Under Neutrosophic Environment, M. G. Brikaa

Neutrosophic Systems with Applications

Neutrosophic set theory plays an important role in dealing with the impreciseness and inconsistency in data encountered in solving real life problems. This paper presents a novel approach to solving a new class of continuous static games within a neutrosophic framework. In the proposed methodology, the neutrosophic continuous static games are redefined into two separate crisp problems: the lower problem and the upper problem. The study further establishes the necessary conditions for determining equilibrium strategies in neutrosophic continuous static games. To demonstrate its effectiveness and practical applicability, the proposed method is validated through a numerical example.

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A Comprehensive Intelligent Traffic Monitoring System Based On A Novel Integration Of Neutrosophic Multi-Criteria Decision-Making Techniques, Mai Mohamed, Amira Salam, Rana Muhammad Zulqarnain, Muhammad Gulistan Apr 2025

A Comprehensive Intelligent Traffic Monitoring System Based On A Novel Integration Of Neutrosophic Multi-Criteria Decision-Making Techniques, Mai Mohamed, Amira Salam, Rana Muhammad Zulqarnain, Muhammad Gulistan

Neutrosophic Systems with Applications

With the spread of road accidents and traffic congestion that costs countries and governments a lot of money in addition to the loss of human lives, and since traditional methods of monitoring traffic have not been as effective as desired, attention has been drawn to the search for more effective solutions to the problem of monitoring and regulating traffic. With the spread of technology and the Internet of Things, UAVs have emerged as a promising tool for monitoring traffic, as they can fly for a sufficient period and operate in difficult climatic conditions, in addition to their ability to monitor …

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Contact Graphs In Fuzzy And Neutrosophic Graphs, Takaaki Fujita Apr 2025

Contact Graphs In Fuzzy And Neutrosophic Graphs, Takaaki Fujita

Neutrosophic Systems with Applications

Graph Theory is a branch of mathematics dedicated to studying graphs, which depict relationships between objects through vertices and edges. A significant focus in this field is the study of contact graphs, where vertices correspond to sets, and edges represent intersections between those sets. To better model uncertainties in real-world situations, several graph types---such as fuzzy, neutrosophic, and Plithogenic graphs---have been developed. This paper investigates the concept of contact graphs within these frameworks, offering insights into their behavior under various uncertain conditions.

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Revisiting Bipolar Neutrosophic Graph And Interval-Valued Neutrosophic Graph, Takaaki Fujita Apr 2025

Revisiting Bipolar Neutrosophic Graph And Interval-Valued Neutrosophic Graph, Takaaki Fujita

Neutrosophic Systems with Applications

Graph theory explores networks composed of nodes (vertices) and their connections (edges). A graph class is a collection of graphs that share common structural properties, defined by specific rules or constraints. This paper examines various models of uncertain graphs, including Fuzzy, Intuitionistic Fuzzy , Neutrosophic, Turiyam Neutrosophic, and Plithogenic Graphs. In particular, this study focuses on Bipolar Graphs and Interval-valued Graphs, analyzing them within the frameworks of Fuzzy, Neutrosophic, Turiyam Neutrosophic, and Plithogenic Graphs.

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Appraisal Of Uncertainty-Driven Financial Performance: Bringing Multi-Criteria Decision Making Techniques With Neutrosophic Theory, Mona Mohamed, Nurhan Alaa, Eman Sayed Apr 2025

Appraisal Of Uncertainty-Driven Financial Performance: Bringing Multi-Criteria Decision Making Techniques With Neutrosophic Theory, Mona Mohamed, Nurhan Alaa, Eman Sayed

Neutrosophic Systems with Applications

Evaluating financial performance is essential yet challenging due to various factors, including ambiguity, insufficient information, and conflicting evaluation criteria. Conventional Multi-Criteria Decision-Making (MCDM) techniques often struggle to manage these complexities effectively. To address these limitations and enhance financial performance assessments, this research proposes an innovative approach integrating Single-Valued Neutrosophic Sets (SVNS) with established MCDM methodologies. SVNS uniquely manages uncertainty by concurrently quantifying degrees of truth, indeterminacy, and falsity within financial data. This research specifically employs entropy-based weighting methods integrated with Additive Ratio Assessment (ARAS) and Multi-Objective Optimization by Ratio Analysis (MOORA) methodologies in the SVNS environment to systematically rank enterprises …

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Rapid Flips Between Warm And Cold Extremes In A Warming World, Sijia Wu, Ming Luo, Gabriel Ngar-Cheung Lau, Wei Zhang, Lin Wang, Zhen Liu, Lijie Lin, Yijing Wang, Erjia Ge, Jianfeng Li, Yuanchao Fan, Yimin Chen, Weilin Liao, Xiaoyu Wang, Xiaocong Xu, Zhixin Qi, Ziwei Huang, Faith Ka Shun Chan, David Yongqin Chen, Xiaoping Liu, Tao Pei Apr 2025

Rapid Flips Between Warm And Cold Extremes In A Warming World, Sijia Wu, Ming Luo, Gabriel Ngar-Cheung Lau, Wei Zhang, Lin Wang, Zhen Liu, Lijie Lin, Yijing Wang, Erjia Ge, Jianfeng Li, Yuanchao Fan, Yimin Chen, Weilin Liao, Xiaoyu Wang, Xiaocong Xu, Zhixin Qi, Ziwei Huang, Faith Ka Shun Chan, David Yongqin Chen, Xiaoping Liu, Tao Pei

Plants, Soils, and Climate Faculty Publications

Rapid temperature flips are sudden shifts from extreme warm to cold or vice versa–both challenge humans and ecosystems by leaving a very short time to mitigate two contrasting extremes, but are yet to be understood. Here, we provide a global assessment of rapid temperature flips from 1961 to 2100. Warm-to-cold flips favorably follow wetter and cloudier conditions, while cold-to-warm flips exhibit an opposite feature. Of the global areas defined by the Intergovernmental Panel on Climate Change, over 60% have experienced more frequent, intense, and rapid flips since 1961, and this trend will expand to most areas in the future. During …

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Vilsmeier–Haack Complex Formation By Fe3O4@Sio2@Cs@Pocl2–X/Dmf: An Efficient Catalyst For Conversion Of Epoxides To Β-Bromoformates, Farzaneh Ebrahimzadeh Apr 2025

Vilsmeier–Haack Complex Formation By Fe3O4@Sio2@Cs@Pocl2–X/Dmf: An Efficient Catalyst For Conversion Of Epoxides To Β-Bromoformates, Farzaneh Ebrahimzadeh

Turkish Journal of Chemistry

The in situ generation of the Vilsmeier–Haack complex was studied by combining Fe3O4@SiO2@CS@POCl2–x with N,N-dimethylformamide (DMF), demonstrating remarkable efficiency and regioselectivity in transforming epoxides into β-bromoformates. The reported yields were notably high and were achieved under mild reaction conditions. Interestingly, the removal of DMF led to the synthesis of vic-dihalide compounds. The product of this transformation depended on the specific details of how the experiment was done, highlighting how sensitive the process is to different ways of conducting the experiment. The use of a magnetic core-shell catalyst, Fe3O …

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Spherical Spiky Zno/Au Nanostructures For Efficient Photoelectrochemical Watersplitting, Kouroush Sali̇mi̇ Apr 2025

Spherical Spiky Zno/Au Nanostructures For Efficient Photoelectrochemical Watersplitting, Kouroush Sali̇mi̇

Turkish Journal of Chemistry

Spiky zinc oxide (ZnO)/Au nanostructures with spherical shape-defined morphologies were synthesized using polydopamine as a starting template for photoelectrochemical H2 production under visible light-emitting diode (LED) illumination. This low-temperature processing technique not only facilitated the fabrication of ideal plasmon-sensitive heterostructures, but also enhanced the electron mobility of the photoanodes, reaching 5.7 mA/cm² [at 1.0 V vs. the reversible hydrogen electrode (RHE)] under visible LED illumination (30 mW/cm2). This notable value was 28 times greater than that observed under dark conditions, primarily attributed to the close Schottky contact between the Au and ZnO spikes. The highest applied bias photon-to-current efficiency value …

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Wo3/Α-Fe2O3/Bi2S3 Ternary Photoanode For Improved Oxygen Evolution Reaction In Photoelectrochemical Water Splitting, Fati̇h Tezcan, Abrar Ahmad, Gülfeza Kardaş Apr 2025

Wo3/Α-Fe2O3/Bi2S3 Ternary Photoanode For Improved Oxygen Evolution Reaction In Photoelectrochemical Water Splitting, Fati̇h Tezcan, Abrar Ahmad, Gülfeza Kardaş

Turkish Journal of Chemistry

This study presents a ternary WO3/α-Fe2O3/Bi2S3 photoanode system suitable for photoelectrochemical water-splitting applications. The WO3/α-Fe2O3 heterojunction is obtained using a hydrothermal approach, while Bi2S3 is deposited onto WO3/α-Fe2O3 via the successive ionic layer adsorption and reaction (SILAR) method. The cycle count is adjusted to determine the optimal photocatalytic photoanode. X-ray diffraction analysis confirms different morphologies and phases for the photoelectrodes: WO3 is deposited as plates with monoclinic phases, α-Fe2O3 as nanorods with hexagonal phases, …

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Synthesis Of Low Ph Stable, Highly Photocatalytic Alginate Hydrogels For Methylene Blue Removal From Wastewater, Emi̇rcan Uysal, Hali̇de Nur Dursun, Emre Can Uysal, Sebahatti̇n Gürmen Apr 2025

Synthesis Of Low Ph Stable, Highly Photocatalytic Alginate Hydrogels For Methylene Blue Removal From Wastewater, Emi̇rcan Uysal, Hali̇de Nur Dursun, Emre Can Uysal, Sebahatti̇n Gürmen

Turkish Journal of Chemistry

Chemical compounds in wastewater, including dye molecules, have been identified as significant concerns for environmental integrity and human health. In this study, adsorbent materials were synthesized from biodegradable polymers to remove methylene blue (MB) from wastewater. Calcium alginate hydrogels were produced and coated with chitosan to enhance their pH stability. Furthermore, the calcium alginate gels were doped with silver nanoparticles to improve their photocatalytic properties, promoting MB degradation and enabling gel reuse. The adsorption behavior of the gels was comprehensively examined under dark conditions, considering factors such as time, solid-to-liquid ratio, temperature, and pollutant concentration, all of which significantly impact …

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Fabrication Of Au–Pd Bimetallic Dendrites And Their Catalytic Application For4-Nitrophenol Reduction, Jun Liu, Xuanyan Liu, Hongguang Liao Apr 2025

Fabrication Of Au–Pd Bimetallic Dendrites And Their Catalytic Application For4-Nitrophenol Reduction, Jun Liu, Xuanyan Liu, Hongguang Liao

Turkish Journal of Chemistry

Bimetal nanocatalysts hold significant application potential in catalytic reactions due to their compositions, morphologies, and electronic structures. In the present work, a series of AuPd alloy dendrites were successfully prepared using sodium formate, without surfactants or templates. A systematic investigation was then conducted to analyze the composition of the AuPd bimetallic dendrites and the effects of preparation conditions on their structure and catalytic performance. The AuPd alloy dendrites were characterized through various techniques, including scanning electron microscopy, transmission electron microscopy, X-ray energy scattering spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The results showed that the Au:Pd ratio in the AuPd …

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Investigation Of The Interaction Conditions Of As2s5 And Cucl2 Compounds In Water And Ethylene Glycol Medium, Huseyn Imanov, Mahnur Jafarli Apr 2025

Investigation Of The Interaction Conditions Of As2s5 And Cucl2 Compounds In Water And Ethylene Glycol Medium, Huseyn Imanov, Mahnur Jafarli

Turkish Journal of Chemistry

The article presents the results of interaction conditions of CuCl2 and As2S5 in ethylene glycol and aquatic medium. Besides, results of the obtained samples' physicochemical properties are given by X-ray diffraction (XRD), differential thermogravimetric (DTG), thermogravimetric (TG), elemental and scanning electron microscope (SEM) methods. It was found that when ethylene glycol and water are used as a solvent and CuCl2 and As2S5 as the initial components, Cu3AsS4 is obtained at a temperature of 323-353 K. According to the results of DTA analysis, it was found that the melting point of obtained samples was 964.4 K contrary to the reactions carried …

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Synthesis Of Thiazole-Integrated Pyrrolotriazinones: Evaluations Of Cytotoxicity And Effects On Pi3k Levels In Cancer Cells, Eylem Kuzu, Ege Arzuk, Fuat Karakuş, Burak Kuzu, Hasan Genç Apr 2025

Synthesis Of Thiazole-Integrated Pyrrolotriazinones: Evaluations Of Cytotoxicity And Effects On Pi3k Levels In Cancer Cells, Eylem Kuzu, Ege Arzuk, Fuat Karakuş, Burak Kuzu, Hasan Genç

Turkish Journal of Chemistry

The synthesis of novel heterocyclic compounds, particularly those targeting critical signaling pathways in cancer, represents a promising approach to drug development. In this study, we designed and synthesized a series of thiazole-integrated pyrrolotriazinone derivatives, aiming to combine the antiproliferative properties of thiazole with the PI3K inhibitory activity of pyrrolotriazinones. The PI3K pathway, which plays a critical role in regulating cell growth, proliferation, and survival, is frequently dysregulated in cancer, making it an attractive target for therapeutic intervention. The synthesized derivatives were evaluated for their cytotoxic activities against MCF-7, A549, and HepG2 cancer cell lines. Their effect on PI3K protein levels …

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Ecofriendly Synthesis And Characterization Of Oxygen-Enriched G-C3n4 From Diverse Precursors For Efficient Organic Dye Decontamination, Muchammad Tamyiz Apr 2025

Ecofriendly Synthesis And Characterization Of Oxygen-Enriched G-C3n4 From Diverse Precursors For Efficient Organic Dye Decontamination, Muchammad Tamyiz

Turkish Journal of Chemistry

Industrial wastewater from sectors such as textiles, printing, and pharmaceuticals contains harmful pollutants, including nonbiodegradable dyes, which pose significant challenges for environmental safety. Neutral red, a cationic dye commonly found in wastewater, obstructs photosynthesis in aquatic ecosystems and carries potential toxicity. Traditional methods of dye removal often prove ineffective due to the chemical stability of these compounds. In this study, oxygen-doped graphitic carbon nitride (O-doped g-C3N4) was synthesized as an innovative photocatalyst for the degradation of neutral red dye under visible light. The material was synthesized through a sustainable process involving the calcination of urea, dicyandiamide, and oxalic acid, and …

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A New Turn Off Fluorescent Nir Probe For Hypochlorous Acid And Its Applications, Ayten Ibrahimova, Ayşe Nur Önem, Mehmet Altun, Emi̇n Ahmet Yeşi̇l, Asli Baysal, Hasan Saygin, Ahu Soyocak, Mustafa Özyürek Apr 2025

A New Turn Off Fluorescent Nir Probe For Hypochlorous Acid And Its Applications, Ayten Ibrahimova, Ayşe Nur Önem, Mehmet Altun, Emi̇n Ahmet Yeşi̇l, Asli Baysal, Hasan Saygin, Ahu Soyocak, Mustafa Özyürek

Turkish Journal of Chemistry

Hypochlorous acid (HOCl) is a potent nonradical oxidant involved in various physiological processes, particularly within the human immune system. In this study, we introduce a novel, rapid, and highly efficient fluorometric method for the detection of HOCl. The method utilizes a near-infrared (NIR)-based fluorescent probe, NIR-QBH, which is characterized by its high sensitivity and chemical stability. NIR-QBH, containing olefinic C=C bonds, exhibits strong NIR emission at 660 nm (λex = 618 nm). The detection mechanism relies on the oxidation of the C=C bond in the NIR-QBH structure by HOCl, resulting in the formation of non-fluorescent products. With a detection limit …

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Inhibition Of Mif With An Allosteric Inhibitor Triggers Cell Cycle Arrest In Acute Myeloid Leukemia, Georgios Pantouris, Leepakshi Khurana, Pathricia Tilstam, Alison Benner, Thomas Yoonsang Cho, Martin Lelaidier, Mathieu Perrée, Zoe Rosenbaum, Lin Leng, Francine Foss, Vineet Bhandari, Amit Verma, Richard Bucala, Elias J. Lolis Apr 2025

Inhibition Of Mif With An Allosteric Inhibitor Triggers Cell Cycle Arrest In Acute Myeloid Leukemia, Georgios Pantouris, Leepakshi Khurana, Pathricia Tilstam, Alison Benner, Thomas Yoonsang Cho, Martin Lelaidier, Mathieu Perrée, Zoe Rosenbaum, Lin Leng, Francine Foss, Vineet Bhandari, Amit Verma, Richard Bucala, Elias J. Lolis

Pacific Faculty Work

Macrophage migration inhibitory factor (MIF) is a key modulator of innate and adaptive immunity that has been extensively reported to promote tumor cell survival, proliferation, and metastasis. A recent study focusing on the microenvironment of acute myeloid leukemia (AML) showed that pharmacological inhibition of MIF signaling, in vitro as well as in vivo, reduces AML cell survival. Such data highlights the crucial role of MIF in AML pathogenesis and support the efforts for developing selective MIF modulators. Here, we report the identification and crystallographic characterization of a MIF inhibitor (compound 1) with an allosteric binding motif. Single point screening of …

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Improving Efficiency Of Wind Flow Modeling For Wildfire Applications Using Analytical Parameterization And Neural Networks, Laura Jane Housley Apr 2025

Improving Efficiency Of Wind Flow Modeling For Wildfire Applications Using Analytical Parameterization And Neural Networks, Laura Jane Housley

Theses and Dissertations

We model wind velocity fields for applications in wildfire modeling. We improve the accuracy of the mass-conserving WindNinja solver without compromising efficient temporal complexity. We consider two approaches: the parameterization method and the neural network method. In the parameterization method, we analyze eddies in the wake of obstacles by parameterizing cavity zones as inspired by the research by Kaplan & Dinar in 1996. Kaplan & Dinar parameterize cavity zones around rectangular buildings, and we approximate a continuous landscape with rectangular buildings in order to extend this parameterization to complex terrains. In the neural network method, we train a U-net CNN …

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