Physical Sciences and Mathematics Commons^™

Surface And Interfacial Design And Control Of High Performing Thermoplastics: Polysulfones And Beyond, Katrina Marie Knauer

Dissertations

The study of a class of materials almost always begins with the development of an understanding of properties in the bulk state. However, it is the study of surface critical phenomena that has led to a number of new important insights into polymer behavior. A systematic understanding of physical properties in the immediate vicinity of surface and interfacial layers, which cannot be deduced by simple extrapolation of bulk properties, is of significant importance for advancements in polymer applications where the interface drives performance, such as in membranes, coatings, drug-delivery systems, medical devices, and composites.

First, the surface and interfacial modification …

Addressing The Issues Of Drug Delivery Via Advanced Macromolecular Design, Brooks Allen Abel

Dissertations

The work described in this dissertation focuses on the development of synthetic approaches toward novel polymer architectures that specifically address the issues of in vivo drug delivery. Successful implementation of the synthetic methodologies described herein required fundamental investigations into the underlying chemistries in ways that now provide greater insights into the nature of the these chemical reactions.

In Section I, the synthesis of tunable pH- and CO₂-responsive sulfonamide-containing polymers using reversible addition-fragmentation chain transfer (RAFT) polymerization is described. Initially, poor polymerization control of methacryloyl sulfonamide (MSA) monomers was observed using traditional RAFT polymerization conditions. Ultimately, reducing the polymerization …

Zephyr: A Social Psychology-Based Mobile Application For Long-Distance Romantic Partners, Dhiraj Bodicherla

Open Access Theses

Long-distance romantic relationships have become quite common nowadays. With CMC tools advancing day-by-day, their usage among LDRs is proliferating rapidly. Attachment-related anxiety and avoidance can block the ability to enjoy happy relationships. During such situations, remembering happy past moments can be comforting. In this study a mobile chat application that enables LDR couples to reminisce about happy moments was developed. This study primarily focuses on evaluating the usability of this mobile application using survey-based methods. System Usability Scale was considered to discuss the outcome of the study. The overall results provide useful recommendations for further improvements in the design of …

Drinking Water Treatment: Salt-Free Water “Softener” Options, Bruce I. Dvorak

Department of Civil and Environmental Engineering: Faculty Publications

New no-salt technologies may be effective in treating hard water, but consumers should carefully investigate product claims prior to buying a specific treatment device.

Hard water is not a health risk, but many Nebraska consumers find hard water to be a nuisance because of mineral buildup on plumbing fixtures, including water heaters; unsightly film on glass and crystal wares; and poor soap and/or detergent performance. Water described as “hard” contains high amounts of dissolved calcium and magnesium, which are positively charged contaminants called cations.

Water hardness often is expressed as grains of hardness per gallon of water (gpg) or milligrams …

From Lights Out To Lights On, Ravi Chidambaram

Asian Management Insights

How Sunlabob went from providing affordable, sustainable energy in rural Laos to becoming an international turnkey operator and co-developer.

Fast Weighted Histograms For Bilateral Filtering And Nearest Neighbor Searching, Shengfeng He, Qingxiong Yang, Rynson W. H. Lau, Ming-Hsuan Yang

Research Collection School Of Computing and Information Systems

The locality sensitive histogram (LSH) injects spatial information into the local histogram in an efficient manner, and has been demonstrated to be very effective for visual tracking. In this paper, we explore the application of this efficient histogram in two important problems. We first extend the LSH to linear time bilateral filtering, and then propose a new type of histogram for efficiently computing edge-preserving nearest neighbor fields (NNFs). While the existing histogram-based bilateral filtering methods are the state of the art for efficient grayscale image processing, they are limited to box spatial filter kernels only. In our first application, we …

Toward Dmd Illuminated Spatial-Temporal Modulated Thermography, Joshua D. Pribe, Srinivas Chakravarthi Thandu, Zhaozheng Yin, Edward C. Kinzel

Computer Science Faculty Research & Creative Works

This paper reports on a system using a Digital Micromirror Device (DMD) to modulate a near-infrared laser source spatially and temporally. The DMD can produce an arbitrary heat source varying both spatially and temporally over the target. When the thermal response of the target surface is recorded using a thermal imager, this provides new possibilities in subsurface defect detection, partially with regard to features whose orientation does not allow them to be resolved using conventional thermographic inspection techniques. In this respect it is similar to conventional focused spot detection approaches; however, the DMD allows the signal to be frequency/phase multiplexed …

Optimizing Selection Of Competing Services With Probabilistic Hierarchical Refinement, Tian Huat Tan, Manman Chen, Jun Sun, Yang Liu, Étienne André, Yinxing Xue, Jin Song Dong

Research Collection School Of Computing and Information Systems

Recently, many large enterprises (e.g., Netflix, Amazon) have decomposed their monolithic application into services, and composed them to fulfill their business functionalities. Many hosting services on the cloud, with different Quality of Service (QoS) (e.g., availability, cost), can be used to host the services. This is an example of competing services. QoS is crucial for the satisfaction of users. It is important to choose a set of services that maximize the overall QoS, and satisfy all QoS requirements for the service composition. This problem, known as optimal service selection, is NPhard. Therefore, an effective method for reducing the search space …

Proof Of Concept For The Forensic Analysis Of Blood Spots To Distinguish Time Since Deposition And Relative Age Of Blood Spot Originator, Roselyn Rodrigues

Chemistry

In the field of forensics, blood is considered a highly useful tool. DNA found in blood is currently viewed as the best source of identifying a suspect; however, DNA analysis is mainly used as a comparative method. DNA analysis can single out a suspect they are physically present in custody or if a match is made through a database of stored profiles, such as the Combined DNA Index System (CODIS).1-3 There are new methods of DNA analysis that can identify a person of African/Caribbean decent, hair and eye color, and even the age of a person.4-6 However, this DNA analysis …

Effect Of Concentration, Temperature, And Base Changes On Retrovirus Dimerization, Ashley Colvin

Chemistry

RNA-RNA junctions between hairpin loops are a common feature of RNA retroviruses, accounting for their high mechanical stability. Dimerization of Moloney Murine Leukemia Virus (MMLV) is dependent on H3 stem loop interactions, which are an example of such a junction. H3 in MMLV dimerizes via a two base pair hairpin loop enhanced by two adjacent stacking bases. All atom, explicit solvent molecular dynamics pulling simulations were performed to examine the stability of the junction. Salt concentrations and temperatures were varied and unstacking times of the flanking bases and breaking times of the kissing bonds were calculated. Survival curves revealed that …

Microdialysis Studies Using Porcine Pancreatic Elastase To Guide Mathematical Modeling Of Microdialysis Sampling For In Vivo Measurements., Mason W. Young

Biomedical Engineering Undergraduate Honors Theses

Microdialysis sampling uses a semi-permeable membrane to allow solute collection by diffusion. When used in conjunction with other instruments, analytes in question can be quantified. Matrix Metalloproteinases (MMPs) are enzymes involved in numerous biological processes where they serve the role of degrading extracellular matrix. Microdialysis sampling, in coordination with further analysis methods, can be used in order to measure the activity of these enzymes in a region of the body instantaneously. The intention of this project is to determine ways of measuring in vitro activity of elastase from porcine pancreas using determined activity values and the collection of elastase products. …

Wormhole Geometries In Fourth-Order Conformal Weyl Gravity, Gabriele U. Varieschi, Kellie L. Ault

Physics Faculty Works

We present an analysis of the classic wormhole geometries based on conformal Weyl gravity, rather than standard general relativity. The main characteristics of the resulting traversable wormholes remain the same as in the seminal study by Morris and Thorne, namely, that effective super-luminal motion is a viable consequence of the metric. Improving on previous work on the subject, we show that for particular choices of the shape and redshift functions the wormhole metric in the context of conformal gravity does not violate the main energy conditions at or near the wormhole throat. Some exotic matter might still be needed at …

Schwarzschild Spacetime And Friedmann-Lemaitre-Robertson-Walker Cosmology, Zachary Cohen

Honors Scholar Theses

The advent of General Relativity via Einstein's field equations revolutionized our understanding of gravity in our solar system and universe. The idea of General Relativity posits that gravity is entirely due to the geometry of the universe -- that is, the mass distribution throughout the universe results in the ``curving" of spacetime, which gives us the physics we see on a large scale. In the framework of General Relativity, we find that the universe behaves differently than was predicted in the model of gravitation developed by Newton. We will derive the general relativistic model for a simple system near a …

The Eagle Programming Language, Samuel G. Horlbeck Olsen

Mathematics, Statistics, and Computer Science Honors Projects

C remains the dominant systems programming language despite many new languages attempting to take its place. Modern languages generally value abstraction and safety over speed and direct control of hardware. They are therefore not well suited to the low-level tasks for which C was designed. This paper introduces a novel programming language, Eagle, which represents a fast, elegant alternative to C. It allows low-level programming while providing optional modern features like reference counting, closures, generators, and classes. In addition to specifying this language and reviewing the current alternatives, the paper describes the implementation of a working Eagle compiler. The language …

Bases For Mckay Centralizer Algebras, Lucas Gagnon

Mathematics, Statistics, and Computer Science Honors Projects

The finite subgroups of the special unitary group SU2 have been classified to be isomorphic to one of the following groups: cyclic, binary dihedral, binary tetrahedral, binary octahedral, and binary icosahedral, of order n, 4n, 24, 48, and 120, respectively. Associated to each group is a representation graph, which by the McKay correspondence is a Dynkin diagram of type Aˆ n−1, Dˆ n+2, Eˆ 6, Eˆ 7, or Eˆ 8. The centralizer algebra Zk(G) = EndG(V ⊗k ) is the algebra of transformations that commute with G acting on the k-fold tensor product of the defining representation V = C …

Building Voters: Exploring Interdependent Preferences In Binary Contexts, Ian Calaway

Mathematics, Statistics, and Computer Science Honors Projects

In this thesis we develop a new method for constructing binary preference orders for given interdependent structures, called characters. We introduce the preference space, which is a vector space of preference vectors. The preference vectors correspond to binary preference orders. We show that the hyperoctahedral group, Z2 o Sn, describes the symmetries of binary preferences orders and then define an action of Z2 o Sn on our preference vectors. We find a natural basis for a preference space. These basis vectors are indexed by subsets of proposals. We show that when completely separable binary preference vectors are decomposed using this …

Synthesis Of Microgel Polymers As Catalysts, Hannah N. Miller

Chemistry & Biochemistry Undergraduate Honors Theses

New developments in organic synthesis show promise in achieving the best catalytic properties for the hydrolysis of glycosidic bonds through microgel polymers and transition metal complexes. A monomer mix of ethylene glycol dimethacrylate, butyl acrylate, and styrene form miniemulsion polymers after sonication and exposure to UV light. Gravimetrical analysis is used to determine the most suitable polymerization conditions by performing experiments at varying pH values, temperatures, monomer amounts, initiator amounts, and lamp heights. The final data show that the best polymerization conditions are a pH of 10.50 at 0°C with a high monomer ratio, 20% initiator amount, and a lamp …

Improving Photocatalytic Activity By Appending A Quinone To Ruthenium Polypyridyl Complex, Amy N. James

Chemistry & Biochemistry Undergraduate Honors Theses

By converting natural light energy into chemical energy, chemists are studying ways to take advantage of clean energy. The rising precedence of “green chemistry” has led to academic interest in the activity of photocatalysts and harnessing visible light in an efficient, accessible, and safe manner. Photochemistry is an upcoming and fascinating field of study that has made significant progress, but also has great potential for future work. By utilizing light as a natural energy source, many reaction processes in chemistry can be viewed with a new perspective. Ru(bpy)₃²⁺ is one of the most widely used photocatalysts. An efficient …

Regulation Of The Reaction Between Cytochrome C And Cytochrome Oxidase, Jennifer Silva-Nash

Chemistry & Biochemistry Undergraduate Honors Theses

Irreversible brain damage is commonly seen in patients that have suffered strokes, cardiac arrest, or other brain ischemia events. The hypoxic conditions result in neuron death, and previous studies have shown that additional damage occurs when blood flow is restored. It is thought that the lack of energy production during post-ischemia events also causes severe brain damage, as the brain heavily depends on oxidative phosphorylation. Cytochrome c (Cyt c) plays a crucial role in this energy production by means of the electron transport chain (ETC), transferring electrons between complexes ΙΙΙ (cytochrome bc1) and ΙV (cytochrome c oxidase, CcO). Mitochondrial …

Placental ‘€˜Omics’€™ Study To Understand The Pathogenesis Of Preeclampsia, Komal Kedia

Theses and Dissertations

Preeclampsia (PE) is a potentially fatal complication of pregnancy characterized by an increase in blood pressure (>140/90 mmHg) and proteinuria (>300 mg/24 hrs), often accompanied by edema. Symptoms of PE start after 20 weeks of gestation. If PE remains untreated, it can lead to eclampsia, grand-mal seizures responsible for most fatalities. PE is believed to affect 2-10% of pregnancies worldwide, and claims the lives of over 75,000 mothers and 500,000 newborns yearly. No therapeutic agents have been developed to prevent or cure PE. Part of the reason for this is the absence of a complete understanding of the …

A Comparative Approach To Question Answering Systems, Josue Balandrano Coronel

Theses and Dissertations

In this paper I will analyze three different algorithms and approaches to implement Question Answering Systems (QA-Systems). I will analyze the efficiency, strengths, and weaknesses of multiple algorithms by explaining them in detail and comparing them with each other. The overarching aim of this thesis is to explore ideas that can be used to create a truly open context QA-System. Open context QA-Systems remain an open problem.

The various algorithms and approaches presented in this work will be focused on complex questions. Complex questions are usually verbose and the context of the question is equally important to answer the query …

Global Entropy Based Greedy Algorithm For Discretization, Sai Jyothsna Jonnalagadda

Theses and Dissertations

Discretization algorithm is a crucial step to not only achieve summarization of continuous attributes but also better performance in classification that requires discrete values as input. In this thesis, I propose a supervised discretization method, Global Entropy Based Greedy algorithm, which is based on the Information Entropy Minimization. Experimental results show that the proposed method outperforms state of the art methods with well-known benchmarking datasets. To further improve the proposed method, a new approach for stop criterion that is based on the change rate of entropy was also explored. From the experimental analysis, it is noticed that the threshold based …

Lie Symmetry To Nonlinear Oscillator Systems And Applications, Xiaoyan Li

Theses and Dissertations

In this paper, we apply the theory of Lie symmetry to study a generalized second-order nonlinear differential equation, which includes several physical nonlinear oscillators such as force-free Helmholtz oscillator, force-free Duffing and Duffing-van der Pol oscillators, modified Emden-type equation and its hierarchy etc, and investigate the dynamical properties of this rather general equation. We identify and classify several new integrable cases for arbitrary values of exponents, which determine the tangent vector as well as the infinitesimal generator. Using the Lie point symmetry, we find the useful infinitesimal generators and canonical coordinates, and obtain the first integrals of the second-order nonlinear …

On Hypergroups Of Order At Most 6, Jordy C. Lopez

Theses and Dissertations

This thesis surveys recent results on hypergroups as defined by Frédéric Marty in [3] and [4] and their relation to association schemes as presented in [5]. We show that every association scheme is a hypergroup. Then, we compile a few general results on hypergroups needed for our investigation of hypergroups with three, four and six elements. From [1] and [7], we give examples of hypergroups that do not come from finite schemes and from no scheme at all. Our main result occurs when considering hypergroups S with six elements that have a non-normal closed subset T of order 2 with …

Development Of A Phased Array Using Lnbs With Non-Synchronized Clocks, James I. Murray

Theses and Dissertations

A passive phased array is an array of antennas in which the phases of the signals on each element are controlled to be added to form a spatial beam. The advantage is that one can steer the beam without physically moving the constituent elements as well as create multiple beams on the sky simultaneously. This has application in the field of satellite and spacecraft communications where there is expected to be a large increase in satellite volume due to the increasing access to space. Traditional phased arrays can become costly to synchronize at satellite down-link frequencies, therefore we have built …

Identification Of Synthetic Chemical Compound Inhibitors Of Pseudomonas Aeruginosa Protein Synthesis And The Development Of Lead Series, Stephanie O. Palmer

Theses and Dissertations

Pseudomonas aeruginosa is a ubiquitous Gram-negative bacteria and a primary cause of nosocomial infections. An aminoacylation/translation (A/T) assay was developed using P. aeruginosa components to perform poly(U) mRNA directed protein synthesis. Using scintillation proximity assay (SPA) technology a high-throughput screening (HTS) platform was developed. A synthetic chemical compound library (>900) was screened, 36 hit compounds were identified and molecular targets were determined. Compounds were analyzed for enzymatic inhibition (IC50) and inhibition of bacterial cultures (MIC). Time-kill studies determined bacterial growth to be bacteriostatic or bactericidal in the presence of inhibitor. Mechanism of action, effects on eukaryotic cytosolic and mitochondrial …

Molecular Dynamic Simulation Studies Of The Androgen Receptor Complexed With 5Α-Dihydrotestosterone And An Allosteric Ligand, Everardo Villarreal Ii

Theses and Dissertations

Receptors are important drug targets for the pharmaceutical industry, since they are involved in many illnesses. Nuclear receptors are a subset of receptors that control a variety of physiological events, by expression of genes from DNA. One of the nuclear receptors, the androgen receptor, is a steroid binding receptor that controls a variety of regulatory and development functions in the body. It is also the cause of some types of cancer, so the inhibition of this receptor is crucial. One of the processes studied to inhibit the function of the receptor is to see if an allosteric ligand, TRIAC, can …

Analysis And Simulation Of A Social Network, Twitter: A Case Study, Jonatan Reyes

Theses and Dissertations

The use of online social networks empowers its users to efficiently disseminate information across traditional social networks. Typically, the weight and value of messages are relative to its readers’ culture and interests. Nevertheless, in some instances, messages take the form of viral phenomenon, which circulates around the world in very short periods of time. Therefore, despite the actual content of the message spread over the network, the determination of the effectiveness of message dissemination across the social network becomes an attractive opportunity for scientific study. Since a meticulous analysis of a complete online social network would require the acquisition of …

Hydrodesulfurization Of Dibenzothiophene Using Comos2, Jacob S. Sollner

Theses and Dissertations

The hydrodesulphurization (HDS) of crude oils is an important industrial process to remove sulfur from fuels. In this study, DBT was used as a model compound to study the removal of sulfur from a decahydronaphthalene solution. The catalyst was synthesized through low pressure pathways in the absence of H2S. All the synthesized catalyst were investigated using a combination of SEM, RAMAN spectroscopy, and XRD. The materials were studied for their ability to remove DBT from solution and the reaction products were analyzed. It was observed that the major reaction pathway was the direct desulphurization pathway and zero order reaction kinetics …

Synthesis And Application Of (R)-3-Methylpyrrolidine-3-Carboylic Acid, Shelby D. Dickerson

Honors Theses

L-Proline is an amino acid widely used in pharmaceutical and biotechnological research due to its catalytic activity and biological relevance. L-Proline has been recognized and utilized as an organocatalyst, which allows cleaner, more sustainable reactions. However, one issue with L-proline is its low solubility in organic systems, limiting its reactivity and efficiency, especially when considering industrial research. Two reactions that utilize L-Proline are the Michael and Aldol but require 100 mol% of L-Proline and 30 mol% of L-Proline, respectively. This research will focus on the synthesis of an analogue of L-Proline utilizing inexpensive, commercially available reagents. A variety of organic …