Favorable Outcomes With Ventricular Assist Device Exchange, 2019 Indiana University School of Medicine
Favorable Outcomes With Ventricular Assist Device Exchange, Megan Carroll, Meghan Tooman, Markian Bochan, Christopher Salerno, Ashwin Ravichandran
The VAD Journal
Left ventricular assist device (LVAD) therapy remains a vital therapeutic option for patients with end-stage heart failure. Unfortunately, adverse events can occur and progress to require consideration for device exchange once the failure of medical management becomes evident, especially when heart transplantation is not possible in a timely manner. The aim of this analysis is to describe the incidence and outcomes of LVAD exchanges at our institution. Between April 2008 and May 2017, 397 patients underwent LVAD implantation, with 32 of those patients subsequently receiving exchange upon the recommendation of our multidisciplinary team due to refractory infection (n=12), device ...
Early Dexamethasone Administration In Adults With Suspected Meningitis Lowers Morbidity And Mortality, 2019 Wayne State University
Early Dexamethasone Administration In Adults With Suspected Meningitis Lowers Morbidity And Mortality, Dana Siegel
Clinical Research in Practice: The Journal of Team Hippocrates
A critical appraisal and clinical application of de Gans J, van de Beek D, Investigators EDiABMS. Dexamethasone in adults with bacterial meningitis. New Eng J Med. 2002;347(20):1549-1556. doi: 10.1056/NEJMoa021334.
Introduction To Biostatistics - Lecture 2: Statistical Inference Procedures, 2019 University of Massachusetts Medical School
Introduction To Biostatistics - Lecture 2: Statistical Inference Procedures, Jonggyu Baek
PEER Liberia Project
This presentation provides an overview of statistical inference procedures in biostatistics, including: hypothesis test for population average; hypothesis test for comparing means; and, power and sample size.
Introduction To Redcap, 2019 Vanderbilt University Medical Center
Introduction To Redcap, Troy Moon
PEER Liberia Project
This presentation provides an overview of REDCap, which is web-based software used to create and manage research databases and participant surveys effectively and responsibly. Topics include: history and background; project setup; using surveys, and applications and tools.
Introduction To Biostatistics - Lecture 1: Introduction And Descriptive Statistics, 2019 University of Massachusetts Medical School
Introduction To Biostatistics - Lecture 1: Introduction And Descriptive Statistics, Jonggyu Baek
PEER Liberia Project
This presentation provides an overview of biostatistics and the basic principles and applications of statistics to problems in clinical and public health settings.
Introduction To Biostatistics - Lecture 3: Statistical Inference For Proportions, 2019 University of Massachusetts Medical School
Introduction To Biostatistics - Lecture 3: Statistical Inference For Proportions, Jonggyu Baek
PEER Liberia Project
This presentation provides an overview of statistical inference for proportions, to address how to estimate the probability of an event in a population of a certain size. Topics include confidence intervals, Chi-square tests, and Fisher's Exact test.
Severity Of Disease And Mortality For Hospitalized Patients With Community-Acquired Viral Pneumonia Compared To Patients With Community-Acquired Bacterial Pneumonia, Richard Y. Kim, Thomas Chandler, Stephen P. Furmanek, Timothy Lee Wiemken, Rodrigo Cavallazzi
The University of Louisville Journal of Respiratory Infections
Background: There exists a large body of literature to help identify, diagnose, treat, and manage community-acquired pneumonia (CAP). Despite this, there is little data that directly compares the clinical syndromes and complications of pure bacterial pneumonia to pure viral pneumonia. Our study compares the clinical presentation, morbidity and mortality of viral vs. bacterial etiologies of CAP.
Methods: This was a secondary data analysis of the Community-Acquired Pneumonia Organization (CAPO) international study database. Data was collected concerning patient demographics, physical examination findings, laboratory findings, radiological findings, severity of illness, and clinical outcomes and stratified according to the two study groups, CAVP ...
Persistent Viral Reservoirs In Lymphoid Tissues In Siv-Infected Rhesus Macaques Of Chinese-Origin On Suppressive Antiretroviral Therapy, 2019 Tulane National Primate Research Center
Persistent Viral Reservoirs In Lymphoid Tissues In Siv-Infected Rhesus Macaques Of Chinese-Origin On Suppressive Antiretroviral Therapy, Summer Siddiqui, Stefanie Perez, Yong Gao, Lara Doyle-Meyers, Brian T. Foley, Qingsheng Li, Binhua Ling
Understanding HIV latent reservoirs in tissues is essential for the development of new strategies targeting these sites for eradication. Here, we assessed the size of latent reservoirs and the source of residual viruses in multiple lymphoid tissues of SIV-infected and fully suppressed rhesus macaques of Chinese-origin (cRMs). Eight cRMs were infected with SIVmac251 and treated with tenofovir and emtricitabine daily for 24 weeks initiated 4 weeks post-infection. Four of the eight animals reached sustained full viral suppression with undetectable viremia. The levels of cell-associated SIV DNA varied in peripheral blood mononuclear cells (PBMCs) and multiple lymphoid tissues, but with higher ...
Relationship Between The Cervical Microbiome, Hiv Status, And Precancerous Lesions, 2019 University of Nebraska - Lincoln
Relationship Between The Cervical Microbiome, Hiv Status, And Precancerous Lesions, Cameron Klein, Daniela Gonzalez, Kandali Samwel, Crispin Kahesa, Julius Mwaiselage, Nirosh Aluthge, Samodha Fernando, John T. West, Charles Wood, Peter C. Angeletti
Nearly all cervical cancers are causally associated with human papillomavirus (HPV). The burden of HPV-associated dysplasias in sub-Saharan Africa is influenced by HIV. To investigate the role of the bacterial microbiome in cervical dysplasia, cytobrush samples were collected directly from cervical lesions of 144 Tanzanian women. The V4 hypervariable region of the 16S rRNA gene was amplified and deep sequenced. Alpha diversity metrics (Chao1, PD whole tree, and operational taxonomic unit [OTU] estimates) displayed significantly higher bacterial richness in HIV-positive patients (P = 0.01) than in HIV-negative patients. In HIV-positive patients, there was higher bacterial richness in patients with high-grade ...
Near-Atomic Structure Of A Giant Virus, 2019 Purdue University
Near-Atomic Structure Of A Giant Virus, Qianglin Fang, Dongjie Zhu, Irina Agarkova, Jagat Adhikari, Thomas Klose, Yue Liu, Zhenguo Chen, Yingyuan Sun, Michael L. Gross, James L. Van Etten, Xinzheng Zhang, Michael G. Rossmann
Although the nucleocytoplasmic large DNA viruses (NCLDVs) are one of the largest group of viruses that infect many eukaryotic hosts, the near-atomic resolution structures of these viruses have remained unknown. Here we describe a 3.5 Å resolution icosahedrally averaged capsid structure of Paramecium bursaria chlorella virus 1 (PBCV-1). This structure consists of 5040 copies of the major capsid protein, 60 copies of the penton protein and 1800 minor capsid proteins of which there are 13 different types. The minor capsid proteins form a hexagonal network below the outer capsid shell, stabilizing the capsid by binding neighboring capsomers together. The ...
A Poxvirus Pseudokinase Represses Viral Dna Replication Via A Pathway Antagonized By Its Paralog Kinase, 2019 University of Nebraska - Lincoln
A Poxvirus Pseudokinase Represses Viral Dna Replication Via A Pathway Antagonized By Its Paralog Kinase, Annabel T. Olson, Zhigang Wang, Amber B. Rico, Matthew S. Wiebe
Poxviruses employ sophisticated, but incompletely understood, signaling pathways that engage cellular defense mechanisms and simultaneously ensure viral factors are modulated properly. For example, the vaccinia B1 protein kinase plays a vital role in inactivating the cellular antiviral factor BAF, and likely orchestrates other pathways as well. In this study, we utilized experimental evolution of a B1 deletion virus to perform an unbiased search for suppressor mutations and identify novel pathways involving B1. After several passages of the ΔB1 virus we observed a robust increase in viral titer of the adapted virus. Interestingly, our characterization of the adapted viruses reveals that ...
Protective Versus Pathologic Pre-Exposure Cytokine Profiles In Dengue Virus Infection, 2018 Walter Reed Army Institute of Research
Protective Versus Pathologic Pre-Exposure Cytokine Profiles In Dengue Virus Infection, Heather Friberg, Coreen M. Beaumier, Sangshin Park, Pamela P. Pazoles, Timothy P. Endy, Anuja Mathew, Jeffrey R. Currier, Richard G. Jarman, Kathryn B. Anderson, Steven Hatch, Stephen J. Thomas, Alan L. Rothman
Open Access Articles
BACKGROUND: Hyperendemic circulation of all four types of dengue virus (DENV-1-4) has expanded globally, fueling concern for increased incidence of severe dengue. While the majority of DENV infections are subclinical, epidemiologic studies suggest that type-cross-reactive immunity can influence disease outcome in subsequent infections. The mechanisms controlling these differential clinical outcomes remain poorly defined.
METHODOLOGY/PRINCIPAL FINDINGS: Blood samples were collected from a cohort of school-aged Thai children who subsequently experienced a subclinical DENV infection or developed dengue illness. PBMC collected prior to infection were stimulated in vitro with DENV and the secretion of 30 cytokines was measured using a multiplexed ...
Vitamin C In The Treatment Of Septic Shock, 2018 James Madison University
Vitamin C In The Treatment Of Septic Shock, Alyson O. Shaughnessy, Matthew Tieszen
Physician Assistant Capstones
Objective:To assess the efficacy of improving outcomes of septic shock treatment with the addition of Vitamin C to standard treatment compared to standard therapy alone. To assess whether or not Vitamin C has a favorable outcome in the treatment of septic shock in terms of decreasing duration of vasopressor usage, reducing duration of intensive care unit (ICU) stay, and improving mortality.
Design: Systematic literature review.
Methods: Searches were conducted in PubMed and Google Scholar using the terms ascorbic acid, sepsis, septic shock, and vasopressors. In PubMed the following filters were used: humans only, clinical trials, studies within the past ...
Retrospective Analysis Of Guideline Recommended Antiretroviral Regimens And Vaccination Schedules For Adult Patients With Human Immunodeficiency Virus (Hiv) In An Infectious Diseases Clinic, 2018 Lehigh Valley Health Network
Retrospective Analysis Of Guideline Recommended Antiretroviral Regimens And Vaccination Schedules For Adult Patients With Human Immunodeficiency Virus (Hiv) In An Infectious Diseases Clinic, Jose A. Roman Pharmd, Jarrod W. Kile Rph, Bcps, Amy Slenker Md, Hope Kincaid Mph, Cph
Department of Pharmacy
No abstract provided.
Non-Neutralizing Antibodies Elicited By Recombinant Lassa-Rabies Vaccine Are Critical For Protection Against Lassa Fever., 2018 Thomas Jefferson University; University of Minho; Government Associate Laboratory, Braga/Guimarães
Non-Neutralizing Antibodies Elicited By Recombinant Lassa-Rabies Vaccine Are Critical For Protection Against Lassa Fever., Tiago Abreu-Mota, Katie R. Hagen, Kurt Cooper, Peter B. Jahrling, Gene Tan, Christoph Wirblich, Reed F. Johnson, Matthias J. Schnell
Department of Microbiology and Immunology Faculty Papers
Lassa fever (LF), caused by Lassa virus (LASV), is a viral hemorrhagic fever for which no approved vaccine or potent antiviral treatment is available. LF is a WHO priority disease and, together with rabies, a major health burden in West Africa. Here we present the development and characterization of an inactivated recombinant LASV and rabies vaccine candidate (LASSARAB) that expresses a codon-optimized LASV glycoprotein (coGPC) and is adjuvanted by a TLR-4 agonist (GLA-SE). LASSARAB elicits lasting humoral response against LASV and RABV in both mouse and guinea pig models, and it protects both guinea pigs and mice against LF. We ...
Characterizing The Gut Microbiota During Plasmodium Infection And Antimalarial Treatment., 2018 University of Louisville
Characterizing The Gut Microbiota During Plasmodium Infection And Antimalarial Treatment., Joshua E. Denny
Electronic Theses and Dissertations
Plasmodium, the parasitic cause of malaria, is a global pathogen, annually causing 216 million infections and 445,000 deaths. As drug resistance continues develop and no effective vaccine is available, it is critical to understand the factors underlying the severity of this disease. Plasmodium is an extra-gastrointestinal tract infection where the parasite infects red blood cells causing clinical malaria. However, recent publications have pointed to interactions between the gut microbiota and malaria. With this in mind, the role of the gut microbiota in malaria infection was studied. C57BL/6 mice from different vendors displayed differential resistance and susceptibility to severe ...
Safely Reducing Opioid Use For Chronic Pain In A Large, Rwca-Funded, Hiv Primary Care Practice, 2018 Lehigh Valley Health Network
Safely Reducing Opioid Use For Chronic Pain In A Large, Rwca-Funded, Hiv Primary Care Practice, Joseph L. Yozviak Do, Facp, Nicholas P. Blankenberg Rn, Julie E. Vitale, Carlos Castillo Rn, Jonathan A. Asayag Msw, Veronica L. Cruz Msw, Margaret Hoffman-Terry Md, Facp, Marcelo Gareca Md, Amy Slenker Md, Robin Heacock Rn, Toby P. Goida Rn, Victoria Matos Rn, Vickie Cunningham Bsn, Rn
Department of Medicine
No abstract provided.
Evidence-Based Medicine, 2018 Yale University
Evidence-Based Medicine, Richard Ssekitoleko
PEER Liberia Project
This presentation provides an overview of the evidence-based medicine approach to clinical medicine and patient care.
Literature Search Handout, 2018 University of Massachusetts Medical School
Literature Search Handout, Patricia A. Mcquilkin
PEER Liberia Project
This handout includes links to recommended website resources for scientific literature searching.
Foundations In Global Health Research Methodologies, 2018 University of Massachusetts Medical School
Foundations In Global Health Research Methodologies, Ann M. Moormann
PEER Liberia Project
This presentation provides an overview of epidemiology and research methodologies, and addresses the following questions: What is epidemiology and translational research? What are standard study designs? How is data collected? How is data analyzed? When to seek IRB approval? How to find a research mentor? How is research funded? Ultimate goals: changes in health‐care practices and public health policies.