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Multi-Scale Motility Amplitude Associated With Suicidal Thoughts In Major Depression, Premananda Indic, Greg Murray, Carlo Maggini, Mario Amore, Tiziana Meschi, Loris Borghi, Ross J. Baldessarini, Paola Salvatore 2017 University of Massachusetts Medical School

Multi-Scale Motility Amplitude Associated With Suicidal Thoughts In Major Depression, Premananda Indic, Greg Murray, Carlo Maggini, Mario Amore, Tiziana Meschi, Loris Borghi, Ross J. Baldessarini, Paola Salvatore

Premananda Indic

Major depression occurs at high prevalence in the general population, often starts in juvenile years, recurs over a lifetime, and is strongly associated with disability and suicide. Searches for biological markers in depression may have been hindered by assuming that depression is a unitary and relatively homogeneous disorder, mainly of mood, rather than addressing particular, clinically crucial features or diagnostic subtypes. Many studies have implicated quantitative alterations of motility rhythms in depressed human subjects. Since a candidate feature of great public-health significance is the unusually high risk of suicidal behavior in depressive disorders, we studied correlations between a measure (vulnerability ...


Multi-Scale Motility Amplitude Associated With Suicidal Thoughts In Major Depression, Premananda Indic, Greg Murray, Carlo Maggini, Mario Amore, Tiziana Meschi, Loris Borghi, Ross J. Baldessarini, Paola Salvatore 2017 University of Massachusetts Medical School

Multi-Scale Motility Amplitude Associated With Suicidal Thoughts In Major Depression, Premananda Indic, Greg Murray, Carlo Maggini, Mario Amore, Tiziana Meschi, Loris Borghi, Ross J. Baldessarini, Paola Salvatore

Premananda Indic

Major depression occurs at high prevalence in the general population, often starts in juvenile years, recurs over a lifetime, and is strongly associated with disability and suicide. Searches for biological markers in depression may have been hindered by assuming that depression is a unitary and relatively homogeneous disorder, mainly of mood, rather than addressing particular, clinically crucial features or diagnostic subtypes. Many studies have implicated quantitative alterations of motility rhythms in depressed human subjects. Since a candidate feature of great public-health significance is the unusually high risk of suicidal behavior in depressive disorders, we studied correlations between a measure (vulnerability ...


Youth Outcomes Of Trauma-Focused Cognitive Behavioral Therapy (Tf-Cbt) In The Child Trauma Training Center (Cttc), Crystaltina Montagna, Jessica L. Griffin, Jessica Dym Bartlett, Genevieve Kane-Howse, MaryBeth Todd 2017 University of Massachusetts Medical School

Youth Outcomes Of Trauma-Focused Cognitive Behavioral Therapy (Tf-Cbt) In The Child Trauma Training Center (Cttc), Crystaltina Montagna, Jessica L. Griffin, Jessica Dym Bartlett, Genevieve Kane-Howse, Marybeth Todd

Jessica L. Griffin

Objectives: Exposure to trauma among youth is common and can cause behavioral, social and functioning problems. Use of evidence-based trauma treatment can reduce post-traumatic stress (PTSD) symptoms and behavioral problems. This poster highlights the outcomes of youth who participated in Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) provided by clinicians who were trained through the University of Massachusetts Medical School (UMMS) Child Trauma Training Center (CTTC).

Methods: 308 youth ages 6-18 were enrolled into the CTTC evaluation with a mean age of 11.31 years (SD = 3.5); over half were female (58.1%), the majority were white (62.3%) and 37 ...


Youth Outcomes Of Trauma-Focused Cognitive Behavioral Therapy (Tf-Cbt) In The Child Trauma Training Center (Cttc), Crystaltina Montagna, Jessica L. Griffin, Jessica Dym Bartlett, Genevieve Kane-Howse, MaryBeth Todd 2017 University of Massachusetts Medical School

Youth Outcomes Of Trauma-Focused Cognitive Behavioral Therapy (Tf-Cbt) In The Child Trauma Training Center (Cttc), Crystaltina Montagna, Jessica L. Griffin, Jessica Dym Bartlett, Genevieve Kane-Howse, Marybeth Todd

Community Engagement and Research Symposia

Objectives: Exposure to trauma among youth is common and can cause behavioral, social and functioning problems. Use of evidence-based trauma treatment can reduce post-traumatic stress (PTSD) symptoms and behavioral problems. This poster highlights the outcomes of youth who participated in Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) provided by clinicians who were trained through the University of Massachusetts Medical School (UMMS) Child Trauma Training Center (CTTC).

Methods: 308 youth ages 6-18 were enrolled into the CTTC evaluation with a mean age of 11.31 years (SD = 3.5); over half were female (58.1%), the majority were white (62.3%) and 37 ...


Dysfunctional Error-Related Processing In Incarcerated Youth With Elevated Psychopathic Traits, J. Michael Maurer, Vaughn R. Steele, Lora M. Cope, Gina M. Vincent, Julia M. Stephen, Vince D. Calhoun, Kent A. Kiehl 2017 University of New Mexico

Dysfunctional Error-Related Processing In Incarcerated Youth With Elevated Psychopathic Traits, J. Michael Maurer, Vaughn R. Steele, Lora M. Cope, Gina M. Vincent, Julia M. Stephen, Vince D. Calhoun, Kent A. Kiehl

Gina M. Vincent

Adult psychopathic offenders show an increased propensity towards violence, impulsivity, and recidivism. A subsample of youth with elevated psychopathic traits represent a particularly severe subgroup characterized by extreme behavioral problems and comparable neurocognitive deficits as their adult counterparts, including perseveration deficits. Here, we investigate response-locked event-related potential (ERP) components (the error-related negativity [ERN/Ne] related to early error-monitoring processing and the error-related positivity [Pe] involved in later error-related processing) in a sample of incarcerated juvenile male offenders (n=100) who performed a response inhibition Go/NoGo task. Psychopathic traits were assessed using the Hare Psychopathy Checklist: Youth Version (PCL:YV ...


Trends In Hospital Admissions Due To Antidepressant-Related Adverse Drug Events From 2001 To 2011 In The U.S., Harish S. Parihar, Hongjun Yin, Jennifer L Gooch, Shari N. Allen, Samuel N. John, Jianwei Xuan 2017 Philadelphia College of Osteopathic Medicine

Trends In Hospital Admissions Due To Antidepressant-Related Adverse Drug Events From 2001 To 2011 In The U.S., Harish S. Parihar, Hongjun Yin, Jennifer L Gooch, Shari N. Allen, Samuel N. John, Jianwei Xuan

Samuel N. John

BACKGROUND: Depression is a prevalent mental health disorder and the fourth leading cause of disability in the world as per the World Health Organization. Use of antidepressants can lead to adverse drug events (ADEs), defined as any injury resulting from medication use. This study aimed to examine changes in hospital admissions due to antidepressant-related ADEs (ArADEs) among different socio-demographic groups and changes in lengths of stay (LOS) and hospital charges in ArADE admissions from 2001 to 2011.

METHODS: The Healthcare Cost and Utilization Project database was used. ArADE admissions in different socio-demographic groups were examined including characteristics such as age ...


Relationship Between Massachusetts Youth Screening Instrument-Second Version And Psychiatric Disorders In Youths In Welfare And Juvenile Justice Institutions In Switzerland, L E. W. Leenarts, C. Dolitzsch, K. Schmeck, J. M. Fegert, Thomas Grisso, M. Schmid 2017 Universitäre Psychiatrische Kliniken

Relationship Between Massachusetts Youth Screening Instrument-Second Version And Psychiatric Disorders In Youths In Welfare And Juvenile Justice Institutions In Switzerland, L E. W. Leenarts, C. Dolitzsch, K. Schmeck, J. M. Fegert, Thomas Grisso, M. Schmid

Thomas Grisso

BACKGROUND: There is growing evidence that it is important to have well-standardized procedures for identifying the mental health needs of youths in welfare and juvenile justice institutions. One of the most widely used tools for mental health screening in the juvenile justice system is the Massachusetts Youth Screening Instrument-second version (MAYSI-2). To contribute to the body of research examining the utility of the MAYSI-2 as a mental health screening tool; the first objective of the current study was to examine the relationship between the MAYSI-2 and the Schedule for Affective Disorders and Schizophrenia for School-Age Children, Present and Lifetime version ...


Trends In Hospital Admissions Due To Antidepressant-Related Adverse Drug Events From 2001 To 2011 In The U.S., Harish S. Parihar, Hongjun Yin, Jennifer L Gooch, Shari N. Allen, Samuel N. John, Jianwei Xuan 2017 Philadelphia College of Osteopathic Medicine

Trends In Hospital Admissions Due To Antidepressant-Related Adverse Drug Events From 2001 To 2011 In The U.S., Harish S. Parihar, Hongjun Yin, Jennifer L Gooch, Shari N. Allen, Samuel N. John, Jianwei Xuan

PCOM Scholarly Papers

BACKGROUND: Depression is a prevalent mental health disorder and the fourth leading cause of disability in the world as per the World Health Organization. Use of antidepressants can lead to adverse drug events (ADEs), defined as any injury resulting from medication use. This study aimed to examine changes in hospital admissions due to antidepressant-related ADEs (ArADEs) among different socio-demographic groups and changes in lengths of stay (LOS) and hospital charges in ArADE admissions from 2001 to 2011.

METHODS: The Healthcare Cost and Utilization Project database was used. ArADE admissions in different socio-demographic groups were examined including characteristics such as age ...


Research Methods In Occupational Health Psychology, Irvin Sam Schonfeld, Chu-Hsiang Chang 2017 CUNY Graduate Center

Research Methods In Occupational Health Psychology, Irvin Sam Schonfeld, Chu-Hsiang Chang

Publications and Research

http://www.springerpub.com/occupational-health-psychology.html

Occupational Health Psychology (OHP) is a rapidly expanding interdisciplinary field that focuses on the science and practice of psychology in promoting and developing workplace health- and safety-related initiatives. This comprehensive text for undergraduate and graduate survey courses is the first to encompass a wide range of key issues in OHP. It draws from the domains of psychology, public health, preventive medicine,nursing, industrial engineering, law, and epidemiology to focus on the theory and practice of protecting and promoting the health, well-being, and safety of individuals in the workplace and improving the quality of work ...


Neurobiology Of The Premonitory Urge In Tourette’S Syndrome: Pathophysiology And Treatment Implications, Andrea E. Cavanna, Kevin J. Black, Mark Hallett, Valerie Voon 2016 Washington University School of Medicine

Neurobiology Of The Premonitory Urge In Tourette’S Syndrome: Pathophysiology And Treatment Implications, Andrea E. Cavanna, Kevin J. Black, Mark Hallett, Valerie Voon

Kevin J. Black, MD

Motor and vocal tics are relatively common motor manifestations identified as the core features of Tourette’s syndrome (TS). Although traditional descriptions have focused on objective phenomenological observations, such as anatomical location, number and frequency of tics, patients’ first-person accounts have consistently reported characteristic subjective correlates. These sensory phenomena are often described as a feeling of mounting inner tension or urge to move (“premonitory urge”), which is transiently relieved by tic expression. This article reviews the existing literature on the clinical and neurobiological aspects of the premonitory urge in patients with TS, with focus on its pathophysiology and possible treatment ...


Into The Light: Using Technology To Develop A Mother/Family Centered Peer Support Network, Shannon Hennig, Katherine Stone, Joanne Nicholson 2016 Postpartum Progress Inc.

Into The Light: Using Technology To Develop A Mother/Family Centered Peer Support Network, Shannon Hennig, Katherine Stone, Joanne Nicholson

Journal of Parent and Family Mental Health

This paper highlights the work of Postpartum Progress Inc., to engage with large online communities of women experiencing a perinatal mental health issue, in order to explore the efficacy of peer support as a treatment modality. "Into the Light" is a Patient Centered Outcomes Research Institute (PCORI) Pipeline to Proposal project that will bring together diverse stakeholders and patients to build collaborative partnerships. Project goals include developing patient engagement, recruitment and dissemination strategies that reflect the needs of this patient population. Increasing patient access to easily understood information about treatment options when making health care decisions and improving patient-centered research ...


Can Tobacco Dependence Provide Insights Into Other Drug Addictions, Joseph R. DiFranza 2016 University of Massachusetts Medical School

Can Tobacco Dependence Provide Insights Into Other Drug Addictions, Joseph R. Difranza

Open Access Articles

Within the field of addiction research, individuals tend to operate within silos of knowledge focused on specific drug classes. The discovery that tobacco dependence develops in a progression of stages and that the latency to the onset of withdrawal symptoms after the last use of tobacco changes over time have provided insights into how tobacco dependence develops that might be applied to the study of other drugs. As physical dependence on tobacco develops, it progresses through previously unrecognized clinical stages of wanting, craving and needing. The latency to withdrawal is a measure of the asymptomatic phase of withdrawal, extending from ...


Recruiting And Retaining Individuals With Serious Mental Illness And Diabetes In Clinical Research: Lessons Learned From A Randomized, Controlled Trial., Stephanie W. Kanuch M.Ed., Kristin A. Cassidy MA, Neal Dawson MD, Melanie Athey MS, Edna Fuentes-Casiano MSSW, Martha Sajatovic MD 2016 The MetroHealth System

Recruiting And Retaining Individuals With Serious Mental Illness And Diabetes In Clinical Research: Lessons Learned From A Randomized, Controlled Trial., Stephanie W. Kanuch M.Ed., Kristin A. Cassidy Ma, Neal Dawson Md, Melanie Athey Ms, Edna Fuentes-Casiano Mssw, Martha Sajatovic Md

Journal of Health Disparities Research and Practice

Abstract: Recruitment and retention of individuals with serious mental illness (SMI) and comorbid diabetes mellitus (DM) in research studies can be challenging with major impediments being difficulties reaching participants via telephone contact, logistic difficulties due to lack of transportation, ongoing psychiatric symptoms, and significant medical complications. Research staff directly involved in recruitment and retention processes of this study reviewed their experiences. The largest barriers at the macro, mediator, and micro levels identified in this study were inclement weather, transportation difficulties, and intermittent and inaccessible telephone contact. Barrier work-around practices included using the health system’s EHR to obtain current phone ...


Burnout Et Dépression, Entre Normal Et Pathologique? Histoire D’Une Différenciation Hasardeuse, Bianchi Renzo, Irvin Sam Schonfeld, Eric Laurent 2016 Université de Neuchâtel

Burnout Et Dépression, Entre Normal Et Pathologique? Histoire D’Une Différenciation Hasardeuse, Bianchi Renzo, Irvin Sam Schonfeld, Eric Laurent

Publications and Research

Initial described in the 1970s, the burnout syndrome has been difficult to characterize. It has been difficult to distinguish it from both clinical and subclinical depressive syndromes. In this chapter, we present a logical analysis of the distinction between burnout and depression. We synthesize the results of studies that bear on that distinction. We find that methodological and the historical separation of two lines of research as well as the lack of articulation between dimensional and categorical approaches to psychopathology.


Relationship Between Massachusetts Youth Screening Instrument-Second Version And Psychiatric Disorders In Youths In Welfare And Juvenile Justice Institutions In Switzerland, L E. W. Leenarts, C. Dolitzsch, K. Schmeck, J. M. Fegert, Thomas Grisso, M. Schmid 2016 Universitäre Psychiatrische Kliniken

Relationship Between Massachusetts Youth Screening Instrument-Second Version And Psychiatric Disorders In Youths In Welfare And Juvenile Justice Institutions In Switzerland, L E. W. Leenarts, C. Dolitzsch, K. Schmeck, J. M. Fegert, Thomas Grisso, M. Schmid

Open Access Articles

BACKGROUND: There is growing evidence that it is important to have well-standardized procedures for identifying the mental health needs of youths in welfare and juvenile justice institutions. One of the most widely used tools for mental health screening in the juvenile justice system is the Massachusetts Youth Screening Instrument-second version (MAYSI-2). To contribute to the body of research examining the utility of the MAYSI-2 as a mental health screening tool; the first objective of the current study was to examine the relationship between the MAYSI-2 and the Schedule for Affective Disorders and Schizophrenia for School-Age Children, Present and Lifetime version ...


Mmp-9 And Mmp-2 Contribute To Neuronal Cell Death In Ipsc Models Of Frontotemporal Dementia With Mapt Mutations, Md Helal Uddin Biswas, Sandra Almeida, Rodrigo Lopez-Gonzalez, Wenjie Mao, Zhijun Zhang, Anna M. Karydas, Michael D. Geschwind, Jacek Biernat, Eva-Maria Mandelkow, Kensuke Futai, Bruce L. Miller, Fen-Biao Gao 2016 University of Massachusetts Medical School

Mmp-9 And Mmp-2 Contribute To Neuronal Cell Death In Ipsc Models Of Frontotemporal Dementia With Mapt Mutations, Md Helal Uddin Biswas, Sandra Almeida, Rodrigo Lopez-Gonzalez, Wenjie Mao, Zhijun Zhang, Anna M. Karydas, Michael D. Geschwind, Jacek Biernat, Eva-Maria Mandelkow, Kensuke Futai, Bruce L. Miller, Fen-Biao Gao

Open Access Articles

How mutations in the microtubule-associated protein tau (MAPT) gene cause frontotemporal dementia (FTD) remains poorly understood. We generated and characterized multiple induced pluripotent stem cell (iPSC) lines from patients with MAPT IVS10+16 and tau-A152T mutations and a control subject. In cortical neurons differentiated from these and other published iPSC lines, we found that MAPT mutations do not affect neuronal differentiation but increase the 4R/3R tau ratio. Patient neurons had significantly higher levels of MMP-9 and MMP-2 and were more sensitive to stress-induced cell death. Inhibitors of MMP-9/MMP-2 protected patient neurons from stress-induced cell death and recombinant MMP-9 ...


Auditory Hallucinations And The Brain's Resting-State Networks: Findings And Methodological Observations, Ben Alderson-Day, Kelly Diederen, Charles Fernyhough, Judith M. Ford, Guillermo Horga, Daniel S. Margulies, Simon McCarthy-Jones, Georg Northoff, James M. Shine, Jessica Turner, Vincent van de Ven, Remko van Lutterveld, Flavie Waters, Renaud Jardri 2016 Durham University

Auditory Hallucinations And The Brain's Resting-State Networks: Findings And Methodological Observations, Ben Alderson-Day, Kelly Diederen, Charles Fernyhough, Judith M. Ford, Guillermo Horga, Daniel S. Margulies, Simon Mccarthy-Jones, Georg Northoff, James M. Shine, Jessica Turner, Vincent Van De Ven, Remko Van Lutterveld, Flavie Waters, Renaud Jardri

Open Access Articles

In recent years, there has been increasing interest in the potential for alterations to the brain's resting-state networks (RSNs) to explain various kinds of psychopathology. RSNs provide an intriguing new explanatory framework for hallucinations, which can occur in different modalities and population groups, but which remain poorly understood. This collaboration from the International Consortium on Hallucination Research (ICHR) reports on the evidence linking resting-state alterations to auditory hallucinations (AH) and provides a critical appraisal of the methodological approaches used in this area. In the report, we describe findings from resting connectivity fMRI in AH (in schizophrenia and nonclinical individuals ...


International Migration Of Doctors, And Its Impact On Availability Of Psychiatrists In Low And Middle Income Countries, Rachel Jenkins, Robert Kydd, Paul Mullen, Kenneth Thomson, James Sculley, Susan Kuper, Joanna Carroll, Oye Gureje, Simon Hatcher, Sharon Brownie, Christopher Carroll, Sheila Hollins, Mai Luen Wong 2016 King’s College London

International Migration Of Doctors, And Its Impact On Availability Of Psychiatrists In Low And Middle Income Countries, Rachel Jenkins, Robert Kydd, Paul Mullen, Kenneth Thomson, James Sculley, Susan Kuper, Joanna Carroll, Oye Gureje, Simon Hatcher, Sharon Brownie, Christopher Carroll, Sheila Hollins, Mai Luen Wong

Sharon Brownie

Background: Migration of health professionals from low and middle income countries to rich countries is a large scale and long-standing phenomenon, which is detrimental to the health systems in the donor countries. We sought to explore the extent of psychiatric migration.

Methods: In our study, we use the respective professional databases in each country to establish the numbers of psychiatrists currently registered in the UK, US, New Zealand, and Australia who originate from other countries. We also estimate the impact of this migration on the psychiatrist population ratios in the donor countries.

Findings: We document large numbers of psychiatrists currently ...


Depression Treatment Decreases Healthcare Expenditures Among Working Age Patients With Comorbid Conditions And Type 2 Diabetes Mellitus Along With Newly-Diagnosed Depression, Rituparna Bhattacharya, Chan Shen, Amy B. Wachholtz, Nilanjana Dwibedi, Usha Sambamthoori 2016 Humana, Inc.

Depression Treatment Decreases Healthcare Expenditures Among Working Age Patients With Comorbid Conditions And Type 2 Diabetes Mellitus Along With Newly-Diagnosed Depression, Rituparna Bhattacharya, Chan Shen, Amy B. Wachholtz, Nilanjana Dwibedi, Usha Sambamthoori

Amy B. Wachholtz

BACKGROUND: There are many studies in the literature on the association between depression treatment and health expenditures. However, there is a knowledge gap in examining this relationship taking into account coexisting chronic conditions among patients with diabetes. We aim to analyze the association between depression treatment and healthcare expenditures among adults with Type 2 Diabetes Mellitus (T2DM) and newly-diagnosed depression, with consideration of coexisting chronic physical conditions.

METHODS: We used multi-state Medicaid data (2000-2008) and adopted a retrospective longitudinal cohort design. Medical conditions were identified using diagnosis codes (ICD-9-CM and CPT systems). Healthcare expenditures were aggregated for each month for ...


Symptoms, Contributing Factors, And Screening For Perinatal Mood And Anxiety Disorders In U.S. Latinas: A Literature Review, Jennifer N. S. Massie 2016 University of San Francisco

Symptoms, Contributing Factors, And Screening For Perinatal Mood And Anxiety Disorders In U.S. Latinas: A Literature Review, Jennifer N. S. Massie

Master's Projects

This literature review was conducted to gather the published information on the topic of perinatal mood and anxiety disorders in the Latina population in the United States. Academic databases were searched for articles published between 2005 and 2016. 60 articles were considered, and a final sample of 36 articles and websites was included in this review.

Evidence suggests that Latina women in the perinatal period (pregnant and up to one year postpartum) in the United States of America tend to have a higher risk and incidence of perinatal mood and anxiety disorders than White women, and a higher risk and ...


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