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Dysfunctional Error-Related Processing In Incarcerated Youth With Elevated Psychopathic Traits, J. Michael Maurer, Vaughn R. Steele, Lora M. Cope, Gina M. Vincent, Julia M. Stephen, Vince D. Calhoun, Kent A. Kiehl 2017 University of New Mexico

Dysfunctional Error-Related Processing In Incarcerated Youth With Elevated Psychopathic Traits, J. Michael Maurer, Vaughn R. Steele, Lora M. Cope, Gina M. Vincent, Julia M. Stephen, Vince D. Calhoun, Kent A. Kiehl

Gina M. Vincent

Adult psychopathic offenders show an increased propensity towards violence, impulsivity, and recidivism. A subsample of youth with elevated psychopathic traits represent a particularly severe subgroup characterized by extreme behavioral problems and comparable neurocognitive deficits as their adult counterparts, including perseveration deficits. Here, we investigate response-locked event-related potential (ERP) components (the error-related negativity [ERN/Ne] related to early error-monitoring processing and the error-related positivity [Pe] involved in later error-related processing) in a sample of incarcerated juvenile male offenders (n=100) who performed a response inhibition Go/NoGo task. Psychopathic traits were assessed using the Hare Psychopathy Checklist: Youth Version (PCL:YV ...


Trends In Hospital Admissions Due To Antidepressant-Related Adverse Drug Events From 2001 To 2011 In The U.S., Harish S. Parihar, Hongjun Yin, Jennifer L Gooch, Shari N. Allen, Samuel N. John, Jianwei Xuan 2017 Philadelphia College of Osteopathic Medicine

Trends In Hospital Admissions Due To Antidepressant-Related Adverse Drug Events From 2001 To 2011 In The U.S., Harish S. Parihar, Hongjun Yin, Jennifer L Gooch, Shari N. Allen, Samuel N. John, Jianwei Xuan

Samuel N. John

BACKGROUND: Depression is a prevalent mental health disorder and the fourth leading cause of disability in the world as per the World Health Organization. Use of antidepressants can lead to adverse drug events (ADEs), defined as any injury resulting from medication use. This study aimed to examine changes in hospital admissions due to antidepressant-related ADEs (ArADEs) among different socio-demographic groups and changes in lengths of stay (LOS) and hospital charges in ArADE admissions from 2001 to 2011.

METHODS: The Healthcare Cost and Utilization Project database was used. ArADE admissions in different socio-demographic groups were examined including characteristics such as age ...


Relationship Between Massachusetts Youth Screening Instrument-Second Version And Psychiatric Disorders In Youths In Welfare And Juvenile Justice Institutions In Switzerland, L E. W. Leenarts, C. Dolitzsch, K. Schmeck, J. M. Fegert, Thomas Grisso, M. Schmid 2017 Universitäre Psychiatrische Kliniken

Relationship Between Massachusetts Youth Screening Instrument-Second Version And Psychiatric Disorders In Youths In Welfare And Juvenile Justice Institutions In Switzerland, L E. W. Leenarts, C. Dolitzsch, K. Schmeck, J. M. Fegert, Thomas Grisso, M. Schmid

Thomas Grisso

BACKGROUND: There is growing evidence that it is important to have well-standardized procedures for identifying the mental health needs of youths in welfare and juvenile justice institutions. One of the most widely used tools for mental health screening in the juvenile justice system is the Massachusetts Youth Screening Instrument-second version (MAYSI-2). To contribute to the body of research examining the utility of the MAYSI-2 as a mental health screening tool; the first objective of the current study was to examine the relationship between the MAYSI-2 and the Schedule for Affective Disorders and Schizophrenia for School-Age Children, Present and Lifetime version ...


Trends In Hospital Admissions Due To Antidepressant-Related Adverse Drug Events From 2001 To 2011 In The U.S., Harish S. Parihar, Hongjun Yin, Jennifer L Gooch, Shari N. Allen, Samuel N. John, Jianwei Xuan 2017 Philadelphia College of Osteopathic Medicine

Trends In Hospital Admissions Due To Antidepressant-Related Adverse Drug Events From 2001 To 2011 In The U.S., Harish S. Parihar, Hongjun Yin, Jennifer L Gooch, Shari N. Allen, Samuel N. John, Jianwei Xuan

PCOM Scholarly Papers

BACKGROUND: Depression is a prevalent mental health disorder and the fourth leading cause of disability in the world as per the World Health Organization. Use of antidepressants can lead to adverse drug events (ADEs), defined as any injury resulting from medication use. This study aimed to examine changes in hospital admissions due to antidepressant-related ADEs (ArADEs) among different socio-demographic groups and changes in lengths of stay (LOS) and hospital charges in ArADE admissions from 2001 to 2011.

METHODS: The Healthcare Cost and Utilization Project database was used. ArADE admissions in different socio-demographic groups were examined including characteristics such as age ...


Neurobiology Of The Premonitory Urge In Tourette’S Syndrome: Pathophysiology And Treatment Implications, Andrea E. Cavanna, Kevin J. Black, Mark Hallett, Valerie Voon 2016 Washington University School of Medicine

Neurobiology Of The Premonitory Urge In Tourette’S Syndrome: Pathophysiology And Treatment Implications, Andrea E. Cavanna, Kevin J. Black, Mark Hallett, Valerie Voon

Kevin J. Black, MD

Motor and vocal tics are relatively common motor manifestations identified as the core features of Tourette’s syndrome (TS). Although traditional descriptions have focused on objective phenomenological observations, such as anatomical location, number and frequency of tics, patients’ first-person accounts have consistently reported characteristic subjective correlates. These sensory phenomena are often described as a feeling of mounting inner tension or urge to move (“premonitory urge”), which is transiently relieved by tic expression. This article reviews the existing literature on the clinical and neurobiological aspects of the premonitory urge in patients with TS, with focus on its pathophysiology and possible treatment ...


Into The Light: Using Technology To Develop A Mother/Family Centered Peer Support Network, Shannon Hennig, Katherine Stone, Joanne Nicholson 2016 Postpartum Progress Inc.

Into The Light: Using Technology To Develop A Mother/Family Centered Peer Support Network, Shannon Hennig, Katherine Stone, Joanne Nicholson

Journal of Parent and Family Mental Health

This paper highlights the work of Postpartum Progress Inc., to engage with large online communities of women experiencing a perinatal mental health issue, in order to explore the efficacy of peer support as a treatment modality. "Into the Light" is a Patient Centered Outcomes Research Institute (PCORI) Pipeline to Proposal project that will bring together diverse stakeholders and patients to build collaborative partnerships. Project goals include developing patient engagement, recruitment and dissemination strategies that reflect the needs of this patient population. Increasing patient access to easily understood information about treatment options when making health care decisions and improving patient-centered research ...


Can Tobacco Dependence Provide Insights Into Other Drug Addictions, Joseph R. DiFranza 2016 University of Massachusetts Medical School

Can Tobacco Dependence Provide Insights Into Other Drug Addictions, Joseph R. Difranza

Open Access Articles

Within the field of addiction research, individuals tend to operate within silos of knowledge focused on specific drug classes. The discovery that tobacco dependence develops in a progression of stages and that the latency to the onset of withdrawal symptoms after the last use of tobacco changes over time have provided insights into how tobacco dependence develops that might be applied to the study of other drugs. As physical dependence on tobacco develops, it progresses through previously unrecognized clinical stages of wanting, craving and needing. The latency to withdrawal is a measure of the asymptomatic phase of withdrawal, extending from ...


Recruiting And Retaining Individuals With Serious Mental Illness And Diabetes In Clinical Research: Lessons Learned From A Randomized, Controlled Trial., Stephanie W. Kanuch M.Ed., Kristin A. Cassidy MA, Neal Dawson MD, Melanie Athey MS, Edna Fuentes-Casiano MSSW, Martha Sajatovic MD 2016 The MetroHealth System

Recruiting And Retaining Individuals With Serious Mental Illness And Diabetes In Clinical Research: Lessons Learned From A Randomized, Controlled Trial., Stephanie W. Kanuch M.Ed., Kristin A. Cassidy Ma, Neal Dawson Md, Melanie Athey Ms, Edna Fuentes-Casiano Mssw, Martha Sajatovic Md

Journal of Health Disparities Research and Practice

Abstract: Recruitment and retention of individuals with serious mental illness (SMI) and comorbid diabetes mellitus (DM) in research studies can be challenging with major impediments being difficulties reaching participants via telephone contact, logistic difficulties due to lack of transportation, ongoing psychiatric symptoms, and significant medical complications. Research staff directly involved in recruitment and retention processes of this study reviewed their experiences. The largest barriers at the macro, mediator, and micro levels identified in this study were inclement weather, transportation difficulties, and intermittent and inaccessible telephone contact. Barrier work-around practices included using the health system’s EHR to obtain current phone ...


Relationship Between Massachusetts Youth Screening Instrument-Second Version And Psychiatric Disorders In Youths In Welfare And Juvenile Justice Institutions In Switzerland, L E. W. Leenarts, C. Dolitzsch, K. Schmeck, J. M. Fegert, Thomas Grisso, M. Schmid 2016 Universitäre Psychiatrische Kliniken

Relationship Between Massachusetts Youth Screening Instrument-Second Version And Psychiatric Disorders In Youths In Welfare And Juvenile Justice Institutions In Switzerland, L E. W. Leenarts, C. Dolitzsch, K. Schmeck, J. M. Fegert, Thomas Grisso, M. Schmid

Open Access Articles

BACKGROUND: There is growing evidence that it is important to have well-standardized procedures for identifying the mental health needs of youths in welfare and juvenile justice institutions. One of the most widely used tools for mental health screening in the juvenile justice system is the Massachusetts Youth Screening Instrument-second version (MAYSI-2). To contribute to the body of research examining the utility of the MAYSI-2 as a mental health screening tool; the first objective of the current study was to examine the relationship between the MAYSI-2 and the Schedule for Affective Disorders and Schizophrenia for School-Age Children, Present and Lifetime version ...


Mmp-9 And Mmp-2 Contribute To Neuronal Cell Death In Ipsc Models Of Frontotemporal Dementia With Mapt Mutations, Md Helal Uddin Biswas, Sandra Almeida, Rodrigo Lopez-Gonzalez, Wenjie Mao, Zhijun Zhang, Anna M. Karydas, Michael D. Geschwind, Jacek Biernat, Eva-Maria Mandelkow, Kensuke Futai, Bruce L. Miller, Fen-Biao Gao 2016 University of Massachusetts Medical School

Mmp-9 And Mmp-2 Contribute To Neuronal Cell Death In Ipsc Models Of Frontotemporal Dementia With Mapt Mutations, Md Helal Uddin Biswas, Sandra Almeida, Rodrigo Lopez-Gonzalez, Wenjie Mao, Zhijun Zhang, Anna M. Karydas, Michael D. Geschwind, Jacek Biernat, Eva-Maria Mandelkow, Kensuke Futai, Bruce L. Miller, Fen-Biao Gao

Open Access Articles

How mutations in the microtubule-associated protein tau (MAPT) gene cause frontotemporal dementia (FTD) remains poorly understood. We generated and characterized multiple induced pluripotent stem cell (iPSC) lines from patients with MAPT IVS10+16 and tau-A152T mutations and a control subject. In cortical neurons differentiated from these and other published iPSC lines, we found that MAPT mutations do not affect neuronal differentiation but increase the 4R/3R tau ratio. Patient neurons had significantly higher levels of MMP-9 and MMP-2 and were more sensitive to stress-induced cell death. Inhibitors of MMP-9/MMP-2 protected patient neurons from stress-induced cell death and recombinant MMP-9 ...


Auditory Hallucinations And The Brain's Resting-State Networks: Findings And Methodological Observations, Ben Alderson-Day, Kelly Diederen, Charles Fernyhough, Judith M. Ford, Guillermo Horga, Daniel S. Margulies, Simon McCarthy-Jones, Georg Northoff, James M. Shine, Jessica Turner, Vincent van de Ven, Remko van Lutterveld, Flavie Waters, Renaud Jardri 2016 Durham University

Auditory Hallucinations And The Brain's Resting-State Networks: Findings And Methodological Observations, Ben Alderson-Day, Kelly Diederen, Charles Fernyhough, Judith M. Ford, Guillermo Horga, Daniel S. Margulies, Simon Mccarthy-Jones, Georg Northoff, James M. Shine, Jessica Turner, Vincent Van De Ven, Remko Van Lutterveld, Flavie Waters, Renaud Jardri

Open Access Articles

In recent years, there has been increasing interest in the potential for alterations to the brain's resting-state networks (RSNs) to explain various kinds of psychopathology. RSNs provide an intriguing new explanatory framework for hallucinations, which can occur in different modalities and population groups, but which remain poorly understood. This collaboration from the International Consortium on Hallucination Research (ICHR) reports on the evidence linking resting-state alterations to auditory hallucinations (AH) and provides a critical appraisal of the methodological approaches used in this area. In the report, we describe findings from resting connectivity fMRI in AH (in schizophrenia and nonclinical individuals ...


International Migration Of Doctors, And Its Impact On Availability Of Psychiatrists In Low And Middle Income Countries, Rachel Jenkins, Robert Kydd, Paul Mullen, Kenneth Thomson, James Sculley, Susan Kuper, Joanna Carroll, Oye Gureje, Simon Hatcher, Sharon Brownie, Christopher Carroll, Sheila Hollins, Mai Luen Wong 2016 King’s College London

International Migration Of Doctors, And Its Impact On Availability Of Psychiatrists In Low And Middle Income Countries, Rachel Jenkins, Robert Kydd, Paul Mullen, Kenneth Thomson, James Sculley, Susan Kuper, Joanna Carroll, Oye Gureje, Simon Hatcher, Sharon Brownie, Christopher Carroll, Sheila Hollins, Mai Luen Wong

Sharon Brownie

Background: Migration of health professionals from low and middle income countries to rich countries is a large scale and long-standing phenomenon, which is detrimental to the health systems in the donor countries. We sought to explore the extent of psychiatric migration.

Methods: In our study, we use the respective professional databases in each country to establish the numbers of psychiatrists currently registered in the UK, US, New Zealand, and Australia who originate from other countries. We also estimate the impact of this migration on the psychiatrist population ratios in the donor countries.

Findings: We document large numbers of psychiatrists currently ...


Depression Treatment Decreases Healthcare Expenditures Among Working Age Patients With Comorbid Conditions And Type 2 Diabetes Mellitus Along With Newly-Diagnosed Depression, Rituparna Bhattacharya, Chan Shen, Amy B. Wachholtz, Nilanjana Dwibedi, Usha Sambamthoori 2016 Humana, Inc.

Depression Treatment Decreases Healthcare Expenditures Among Working Age Patients With Comorbid Conditions And Type 2 Diabetes Mellitus Along With Newly-Diagnosed Depression, Rituparna Bhattacharya, Chan Shen, Amy B. Wachholtz, Nilanjana Dwibedi, Usha Sambamthoori

Amy B. Wachholtz

BACKGROUND: There are many studies in the literature on the association between depression treatment and health expenditures. However, there is a knowledge gap in examining this relationship taking into account coexisting chronic conditions among patients with diabetes. We aim to analyze the association between depression treatment and healthcare expenditures among adults with Type 2 Diabetes Mellitus (T2DM) and newly-diagnosed depression, with consideration of coexisting chronic physical conditions.

METHODS: We used multi-state Medicaid data (2000-2008) and adopted a retrospective longitudinal cohort design. Medical conditions were identified using diagnosis codes (ICD-9-CM and CPT systems). Healthcare expenditures were aggregated for each month for ...


Symptoms, Contributing Factors, And Screening For Perinatal Mood And Anxiety Disorders In U.S. Latinas: A Literature Review, Jennifer N. S. Massie 2016 University of San Francisco

Symptoms, Contributing Factors, And Screening For Perinatal Mood And Anxiety Disorders In U.S. Latinas: A Literature Review, Jennifer N. S. Massie

Master's Projects

This literature review was conducted to gather the published information on the topic of perinatal mood and anxiety disorders in the Latina population in the United States. Academic databases were searched for articles published between 2005 and 2016. 60 articles were considered, and a final sample of 36 articles and websites was included in this review.

Evidence suggests that Latina women in the perinatal period (pregnant and up to one year postpartum) in the United States of America tend to have a higher risk and incidence of perinatal mood and anxiety disorders than White women, and a higher risk and ...


Data Citation In Neuroimaging: Proposed Best Practices For Data Identification And Attribution, Leah B. Honor, Christian Haselgrove, Jean A. Frazier, David N. Kennedy 2016 University of Massachusetts Medical School

Data Citation In Neuroimaging: Proposed Best Practices For Data Identification And Attribution, Leah B. Honor, Christian Haselgrove, Jean A. Frazier, David N. Kennedy

Psychiatry Publications and Presentations

Data sharing and reuse, while widely accepted as good ideas, have been slow to catch on in any concrete and consistent way. One major hurdle within the scientific community has been the lack of widely accepted standards for citing that data, making it difficult to track usage and measure impact. Within the neuroimaging community, there is a need for a way to not only clearly identify and cite datasets, but also to derive new aggregate sets from multiple sources while clearly maintaining lines of attribution. This work presents a functional prototype of a system to integrate Digital Object Identifiers (DOI ...


Association Of Common Mental Disorder Symptoms With Health And Healthcare Factors Among Women In Rural Western India: Results Of A Cross-Sectional Survey, Apurv Soni, Nisha Fahey, Nancy Byatt, Anusha Prabhakaran, Tiffany A. Moore Simas, Jagdish Vankar, Ajay Phatak, Eileen O'Keefe, Jeroan J. Allison, Somashekhar Nimbalkar 2016 University of Massachusetts Medical School

Association Of Common Mental Disorder Symptoms With Health And Healthcare Factors Among Women In Rural Western India: Results Of A Cross-Sectional Survey, Apurv Soni, Nisha Fahey, Nancy Byatt, Anusha Prabhakaran, Tiffany A. Moore Simas, Jagdish Vankar, Ajay Phatak, Eileen O'Keefe, Jeroan J. Allison, Somashekhar Nimbalkar

Nancy Byatt

OBJECTIVES: Information about common mental disorders (CMD) is needed to guide policy and clinical interventions in low-income and middle-income countries. This study's purpose was to characterise the association of CMD symptoms with 3 inter-related health and healthcare factors among women from rural western India based on a representative, cross-sectional survey.

SETTING: Surveys were conducted in the waiting area of various outpatient clinics at a tertiary care hospital and in 16 rural villages in the Anand district of Gujarat, India.

PARTICIPANTS: 700 Gujarati-speaking women between the ages of 18-45 years who resided in the Anand district of Gujarat, India, were ...


Evaluation Of Tobacco Use On Chinese Population Through Attoc Model: A Cross-Sectional Survey On Hospitalized Psychiatric Patients, Xue Wang, Zugui Peng, Douglas M. Ziedonis, Chaomin Wang, Bo Yu, Tao Li 2016 Sichuan University

Evaluation Of Tobacco Use On Chinese Population Through Attoc Model: A Cross-Sectional Survey On Hospitalized Psychiatric Patients, Xue Wang, Zugui Peng, Douglas M. Ziedonis, Chaomin Wang, Bo Yu, Tao Li

Douglas M. Ziedonis

OBJECTIVES: To evaluate the feasibility of Addressing Tobaccos through Organizational Change (ATTOC) intervention to Chinese psychiatric patients, and to better address tobacco use through the ATTOC intervention model in the context of China.

METHODS: The study was conducted in Mental Health Center of West China Hospital in 2010. A total of 100 hospitalized psychiatric patients were recruited to carry out ATTOC intervention. Subjects suffers from mental illness were diagnosed by professional psychiatrists according to the International Statistical Classification of Diseases (ICD-10) criteria.

RESULTS: The prevalence of tobacco use in hospitalized psychiatric patients were closely correlated with the type of mental ...


Therapeutic Assignments: Structured Framework For Interaction Between Medical Students And Patients On Psychiatry Clerkships, Yael Dvir, Isheeta Zalpuri 2016 University of Massachusetts Medical School

Therapeutic Assignments: Structured Framework For Interaction Between Medical Students And Patients On Psychiatry Clerkships, Yael Dvir, Isheeta Zalpuri

Yael Dvir

Medical students enjoy high level of patient contact on psychiatric clerkships. They have felt that forming a relationship with a patient can have therapeutic effects by imparting hope, decreasing their isolation and providing individualized attention. However students have encountered difficulties forming alliance with their patients, either due to acuity of illness such as psychosis or due to character pathology, addiction etc. They need to feel comfortable dealing with more difficult situations such as extremes of emotion or breaks with reality. Interviewing skills must be continually developed. We hope that Therapeutic Assignments (TA) will: provide a medium for students to improve ...


Paternal Postpartum Depression, Kathleen Biebel, Shums Alikhan 2016 University of Massachusetts Medical School

Paternal Postpartum Depression, Kathleen Biebel, Shums Alikhan

Journal of Parent and Family Mental Health

While postpartum depression (PPD) has historically been associated primarily with mothers, recently there has been increased awareness of the experience of fathers and strategies to address postpartum depression in men. For fathers willing to seek help, the lack of recognition of paternal PPD results in limited supports and treatments. Given the potential implications of paternal PPD, it is essential for new fathers and their healthcare providers to recognize the prevalence of paternal PPD, the symptoms, and the challenges surrounding this issue for men.


Growing Organizational Capacity To Facilitate The Streamlining Of Patients With Psychiatric Disorders In A Community Academic Health Network; An Eight Year Review, Edward R. Norris MD, FAPA, FAPM, Michael W. Kaufmann MD, David B. Burmeister DO, Muhamad Aly Rifai MD, Laurence P. Karper MD, Ralph A. Primelo MD 2016 Lehigh Valley Health Network

Growing Organizational Capacity To Facilitate The Streamlining Of Patients With Psychiatric Disorders In A Community Academic Health Network; An Eight Year Review, Edward R. Norris Md, Fapa, Fapm, Michael W. Kaufmann Md, David B. Burmeister Do, Muhamad Aly Rifai Md, Laurence P. Karper Md, Ralph A. Primelo Md

David Burmeister, DO, FACEP, CPE

No abstract provided.


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