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Depressive Symptoms In People With Vision Impairment: A Cross-Sectional Study To Identify Who Is Most At Risk, Claire Nollett, Barbara Ryan, Nathan Bray, Catey Bunce, Robin J. Casten, Rhiannon Tudor Edwards, David Gillespie, Daniel J. Smith, Miles Stanford, Tom H. Margrain 2019 Cardiff University

Depressive Symptoms In People With Vision Impairment: A Cross-Sectional Study To Identify Who Is Most At Risk, Claire Nollett, Barbara Ryan, Nathan Bray, Catey Bunce, Robin J. Casten, Rhiannon Tudor Edwards, David Gillespie, Daniel J. Smith, Miles Stanford, Tom H. Margrain

Department of Psychiatry and Human Behavior Faculty Papers

Objective To identify the risk factors for significant depressive symptoms in people with visual impairment in England and Wales to provide information on who is most at risk and to whom support services could be targeted in future. Design A cross-sectional study using baseline data from a pragmatic randomised controlled trial. Setting and participants 990 participants aged 18 or over attending 1 of 14 low-vision rehabilitation primary care optometry-based clinics in South Wales or two hospital clinics in London. Outcome measure A score of ≥6 on the Geriatric Depression Scale-15 was classed as clinically significant depressive symptoms. Results In a ...


Using Picture-Story Books To Help Families Understand Turbulent Parental Emotions In Families With Small Children, Anne Sved Williams, Marie Jonsson-Harrison 2018 University of Adelaide

Using Picture-Story Books To Help Families Understand Turbulent Parental Emotions In Families With Small Children, Anne Sved Williams, Marie Jonsson-Harrison

Journal of Parent and Family Mental Health

A parent’s struggle to manage their emotions may have significant impact on small children. Helping a child understand in the here and now about what is going on for the parent, without blaming that parent or the child, may be useful for the child. It may also lead the child to seek different models of managing emotions and self-concepts. Reading books with children, or bibliotherapy, could be useful for parents who experience stress-related “meltdowns” or perhaps live with mental health conditions such as borderline personality disorder, and for those working with small children in educational, child care or child ...


The Critical Need For Mental Health Education To Be Mandated In New Mexico's Public Schools, Bonnie L. Murphy 2018 University of New Mexico

The Critical Need For Mental Health Education To Be Mandated In New Mexico's Public Schools, Bonnie L. Murphy

Shared Knowledge Conference

Based on a review of research and best practices in mental health awareness and skills, this inquiry project argues for state legislative policies that would require mental health awareness and skills in the K-12 curriculum. Mental health affects individual accomplishments in every stage of people’s lives beginning in early childhood and throughout the life cycle. Prevention and treatment of mental illness plays a key role in the ability of an individual to cope with loss and develop resiliency and perseverance in challenging times and to make better decisions that improve the individual’s life and the lives of those ...


Ethical Implications Of Treatment For Gender Dysphoria In Youth, Kelsey Hayes 2018 College of Our Lady of the Elms

Ethical Implications Of Treatment For Gender Dysphoria In Youth, Kelsey Hayes

Online Journal of Health Ethics

This manuscript explores ethical implications on treatment for youth with diagnosed gender dysphoria. The ethical considerations outlined and analyzed in this essay involve illuminating an understanding of whether the administration of pubertal suppression with GnRH agonists, and cross-sex hormones to children with gender dysphoria is morally justified as treatment to manage their psychological distress, or if safer more understood alternatives exist. This essay emphasizes that as health care professionals we must ensure youth with gender dysphoria receive adequate medical treatment and care however, this essay concludes through extensive literature review, that the use of inconclusive and under researched methods to ...


Mediterranean Diet Adherence And Rate Of Cerebral Aβ-Amyloid Accumulation: Data From The Australian Imaging, Biomarkers And Lifestyle Study Of Ageing, Stephanie Rainey-Smith, Yian Gu, Samantha Gardener, James D Doecke, Victor L Villemagne, Belinda M Brown, Kevin Taddei, Simon M Laws, Hamid R. Sohrabi, MIchael Weinborn, David Ames, Christopher Fowler, S Lance Macaulay, Paul Maruff, Colin L Masters, Olivier Salvado, Christopher C Rowe, Nikolaos Scarmeas, Ralph N. Martins 2018 Edith Cowan University

Mediterranean Diet Adherence And Rate Of Cerebral Aβ-Amyloid Accumulation: Data From The Australian Imaging, Biomarkers And Lifestyle Study Of Ageing, Stephanie Rainey-Smith, Yian Gu, Samantha Gardener, James D Doecke, Victor L Villemagne, Belinda M Brown, Kevin Taddei, Simon M Laws, Hamid R. Sohrabi, Michael Weinborn, David Ames, Christopher Fowler, S Lance Macaulay, Paul Maruff, Colin L Masters, Olivier Salvado, Christopher C Rowe, Nikolaos Scarmeas, Ralph N. Martins

ECU Publications Post 2013

Accumulating research has linked Mediterranean diet (MeDi) adherence with slower cognitive decline and reduced Alzheimer's disease (AD) risk. However, no study to-date has examined the relationship between MeDi adherence and accumulation of cerebral Aβ-amyloid (Aβ; a pathological hallmark of AD) in older adults. Cognitively normal healthy control participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing completed the Cancer Council of Victoria Food Frequency Questionnaire at baseline, which was used to construct a MeDi score for each participant (score range 0-9; higher score indicating higher adherence). Cerebral Aβ load was quantified by Pittsburgh Compound B positron ...


Meeting The Intergenerational Needs Of Families Where A Parent Has A Mental Illness, Melinda Goodyear, Myfanwy McDonald, Henry von Doussa, Rose Cuff, Beth Dunlop 2018 School of Rural Health, Monash University and the Parenting Research Centre

Meeting The Intergenerational Needs Of Families Where A Parent Has A Mental Illness, Melinda Goodyear, Myfanwy Mcdonald, Henry Von Doussa, Rose Cuff, Beth Dunlop

Journal of Parent and Family Mental Health

Parental mental illness can have significant psychological, social and economic impacts on families. Because of the potential impact of a parent’s mental illness on children, it can also have an “intergenerational” impact. For example, children may develop a heightened awareness of their parent’s symptoms, become burdened with caring responsibilities and may even develop their own mental health conditions though a mix of genetic and environmental influences. It is important for services to address the intergenerational impacts of parental mental illness. This issue brief is about one program in Australia that may be able to meet the intergenerational needs ...


Quality Of Life In Romanian Patients With Schizophrenia Based On Gender, Type Of Schizophrenia, Therapeutic Approach, And Family History, Elena Alina Rosca, Ovidiu Eugen Alexinschi, Călin Brîncuș, Valentin Petre Matei, Ana Giurgiuca 2018 Carol Davila University of Medicine and Pharmacy, Alexandru Obregia Clinical Hospital of Psychiatry, Department of Psychiatry, Bucharest, Romania

Quality Of Life In Romanian Patients With Schizophrenia Based On Gender, Type Of Schizophrenia, Therapeutic Approach, And Family History, Elena Alina Rosca, Ovidiu Eugen Alexinschi, Călin Brîncuș, Valentin Petre Matei, Ana Giurgiuca

Journal of Mind and Medical Sciences

The low quality of life of patients with schizophrenia has been extensively discussed and investigated. Various aspects from gender, socio-demographic profile, and/or type of neuroleptic treatment have been taken into account in describing this condition. The purpose of this study is to assess the perceived quality of life of Romanian patients suffering from schizophrenia and to correlate it with gender differences, type of schizophrenia, family history of psychiatric illness, and type of antipsychotic treatment. 143 patients diagnosed with schizophrenia according to DSM IV-TR and ICD 10 were included in the study. Social demographic data were documented and further assessment ...


Disrupted Asymmetry Of Inter- And Intra-Hemispheric Functional Connectivity In Patients With Drug-Naive, First-Episode Schizophrenia And Their Unaffected Siblings, Furong Zhu, Feng Liu, Wenbin Guo, Jindong Chen, Qinji Su, Zhikun Zhang, Huabing Li, Xiaoduo Fan, Jingping Zhao 2018 The Second Xiangya Hospital of Central South University

Disrupted Asymmetry Of Inter- And Intra-Hemispheric Functional Connectivity In Patients With Drug-Naive, First-Episode Schizophrenia And Their Unaffected Siblings, Furong Zhu, Feng Liu, Wenbin Guo, Jindong Chen, Qinji Su, Zhikun Zhang, Huabing Li, Xiaoduo Fan, Jingping Zhao

Open Access Articles

BACKGROUND: Lack of normal asymmetry in the brain has been reported in patients with schizophrenia. However, it remains unclear whether disrupted asymmetry originates from inter-hemispheric functional connectivity (FC) and/or intra-hemispheric FC in this patient population.

METHODS: Forty-four patients with drug-naive, first-episode schizophrenia, 42 unaffected siblings, and 44 healthy controls underwent resting-state functional magnetic resonance imaging (fMRI) scan. The parameter of asymmetry (PAS) and support vector machine (SVM) were used to analyze the data. Patients were treated with olanzapine for 8 weeks.

FINDINGS: Compared with healthy controls, patients showed lower PAS scores in the left middle temporal gyrus (MTG)/inferior ...


Telepsychiatry: Access In Rural Areas, David P. Paul III, Brianna Washington, Annie Robinson, Mike Tonnie, Alberto Coustasse 2018 Marshall University

Telepsychiatry: Access In Rural Areas, David P. Paul Iii, Brianna Washington, Annie Robinson, Mike Tonnie, Alberto Coustasse

Management Faculty Research

Rural areas have experienced higher than average healthcare workforce problems, especially concerning limited access to mental health services. Telepsychiatry may provide at least a partial solution, as it has improved access and quality of care available in rural environments despite implementation problems. As technology continues to advance access, telepsychiatry will also need to strengthen making access more readily available. Additional research is required to identify modalities and diverse methods that can be used to increase access to mental health services further and improve outcomes in rural and underserved areas.


Resting State Functional Connectivity In Patients With Remitted Psychotic Depression: A Multi-Centre Stop-Pd Study, Nicholas H. Neufeld, Benoit H. Mulsant, Erin W. Dickie, Barnett S. Meyers, George S. Alexopoulos, Anthony J. Rothschild, Ellen M. Whyte, Matthew J. Hoptman, Arash Nazeri, Jonathan Downar, Alastair J. Flint, Aristotle N. Voineskos 2018 University of Toronto

Resting State Functional Connectivity In Patients With Remitted Psychotic Depression: A Multi-Centre Stop-Pd Study, Nicholas H. Neufeld, Benoit H. Mulsant, Erin W. Dickie, Barnett S. Meyers, George S. Alexopoulos, Anthony J. Rothschild, Ellen M. Whyte, Matthew J. Hoptman, Arash Nazeri, Jonathan Downar, Alastair J. Flint, Aristotle N. Voineskos

Open Access Articles

BACKGROUND: There is paucity of neurobiological knowledge about major depressive disorder with psychotic features ("psychotic depression"). This study addresses this knowledge gap by using resting state functional magnetic resonance imaging (R-fMRI) to compare functional connectivity in patients with psychotic depression and healthy controls.

METHODS: We scanned patients who participated in a randomized controlled trial as well as healthy controls. All patients achieved remission from depressive and psychotic symptoms with sertraline and olanzapine. We employed Independent Component Analysis in independent samples to isolate the default mode network (DMN) and compared patients and controls.

FINDINGS: The Toronto sample included 28 patients (mean ...


Lurasidone Is Not Associated With Risk Of Qtc Prolongation, Halimah Y. Oral 2018 Wayne State University School of Medicine

Lurasidone Is Not Associated With Risk Of Qtc Prolongation, Halimah Y. Oral

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Meltzer HY, Cucchiaro J, Silva R, Ogasa M, Phillips D, Xu J, Kalali AH, Scheizer E, Pikalov A, Loebel A. Lurasidone in the treatment of schizophrenia: a randomized, double-blind, placebo- and olanzapine-controlled study. Am J Psychiatry. 2011 Sep;168(9):957-67. doi: https://doi.org/10.1176/appi.ajp.2011.10060907.


Musical Hallucinations Treated With Atypical Antipsychotics In A Geriatric Population – A Case Series, Adam Schindzielorz MD, D. Scott Murphy MD, Suzanne Holroyd MD 2018 Marshall University

Musical Hallucinations Treated With Atypical Antipsychotics In A Geriatric Population – A Case Series, Adam Schindzielorz Md, D. Scott Murphy Md, Suzanne Holroyd Md

Suzanne Holroyd

Musical hallucinations have been likened to the auditory equivalent of Charles Bonnet Syndrome, which involves complex visual hallucinations, most often in the context of visual impairment. Musical hallucination frequently take the form of hymns, carols, and show-tunes and are strongly associated with hearing loss, with some studies suggesting a prevalence of 2.5–3.6% in the hearing impaired. Musical hallucinations are typically treated with anticonvulsant and anticholinesterase medications, with some studies having evaluated the efficacy of sedative hypnotics, antipsychotics and antidepressants in various psychiatric and medical subpopulations suggesting a heterogeneous spectrum of causes for this disorder.

We present two ...


Relationship Between Theory Of Mind, Emotion Recognition, And Social Synchrony In Adolescents With And Without Autism, Paula Fitzpatrick, Jean A. Frazier, David E. Cochran, Teresa V. Mitchell, Caitlin Coleman, R. C. Schmidt 2018 Assumption College

Relationship Between Theory Of Mind, Emotion Recognition, And Social Synchrony In Adolescents With And Without Autism, Paula Fitzpatrick, Jean A. Frazier, David E. Cochran, Teresa V. Mitchell, Caitlin Coleman, R. C. Schmidt

Open Access Articles

Difficulty in social communication and interaction is a primary diagnostic feature of ASD. Research has found that adolescents with ASD display various impairments in social behavior such as theory of mind (ToM), emotion recognition, and social synchrony. However, not much is known about the relationships among these dimensions of social behavior. Adolescents with and without ASD participated in the study. ToM ability was measured by viewing social animations of geometric shapes, recognition of facial emotions was measured by viewing pictures of faces, and synchrony ability was measured with a spontaneously arising interpersonal movement task completed with a caregiver and an ...


Guidance For Switching From Off-Label Antipsychotics To Pimavanserin For Parkinson’S Disease Psychosis: An Expert Consensus, Kevin J. Black, Henry Nasrallah, Stuart Isaacson, Mark Stacy, Rajesh Pahwa, Charles H. Adler, Gustavo Alva, Jeffrey W. Cooney, Daniel Kremens, Matthew A. Menza, Jonathan M. Meyer, Ashwin A. Patkar, Tanya Simuni, Debbi A. Morrissette, Stephen Stahl 2018 Washington University in St. Louis

Guidance For Switching From Off-Label Antipsychotics To Pimavanserin For Parkinson’S Disease Psychosis: An Expert Consensus, Kevin J. Black, Henry Nasrallah, Stuart Isaacson, Mark Stacy, Rajesh Pahwa, Charles H. Adler, Gustavo Alva, Jeffrey W. Cooney, Daniel Kremens, Matthew A. Menza, Jonathan M. Meyer, Ashwin A. Patkar, Tanya Simuni, Debbi A. Morrissette, Stephen Stahl

Kevin J. Black, MD

Patients with Parkinson’s disease psychosis (PDP) are often treated with an atypical antipsychotic, especially quetiapine or clozapine, but side effects, lack of sufficient efficacy, or both may motivate a switch to pimavanserin, the first medication approved for management of PDP. How best to implement a switch to pimavanserin has not been clear, as there are no controlled trials or case series in the literature to provide guidance. An abrupt switch may interrupt partially effective treatment or potentially trigger rebound effects from antipsychotic withdrawal, whereas cross-taper involves potential drug interactions. A panel of experts drew from published data, their experience ...


An Investigation Of The Neurobiology Of Psychogenic Non-Epileptic Seizures, Finian O'Brien 2018 The Royal College of Surgeons in Ireland

An Investigation Of The Neurobiology Of Psychogenic Non-Epileptic Seizures, Finian O'Brien

PhD theses

Background: Psychogenic non-epileptic seizures (PNES) are paroxysmal episodes of seizure-like behaviour that superficially resemble epileptic events, but lack EEG correlates of epilepsy. Diagnosis is often delayed and the condition is associated with significant impairments of general functioning. At the time that this project was commenced, there were few neuropsychological studies of PNES and the neural correlates of this condition were unknown.

Aims: This project aimed to firstly, examine the prevalence and management of PNES in an Irish epilepsy monitoring unit (EMU) and secondly to examine neuropsychiatric, neuropsychological, structural and functional neuroimaging correlates of adults with PNES.

Methods: Standardised assessments and ...


Contextualization Of Psychological Treatments For Government Health Systems In Low-Resource Settings: Group Interpersonal Psychotherapy For Caregivers Of Children With Nodding Syndrome In Uganda., Byamah B Mutamba, Brandon A Kohrt, James Okello, Janet Nakigudde, Bernard Opar, Seggane Musisi, William Bazeyo, Joop de Jong 2018 George Washington University

Contextualization Of Psychological Treatments For Government Health Systems In Low-Resource Settings: Group Interpersonal Psychotherapy For Caregivers Of Children With Nodding Syndrome In Uganda., Byamah B Mutamba, Brandon A Kohrt, James Okello, Janet Nakigudde, Bernard Opar, Seggane Musisi, William Bazeyo, Joop De Jong

Psychiatry and Behavioral Sciences Faculty Publications

BACKGROUND: Evidence for the effectiveness of psychological treatments in low- and middle-income countries is increasing. However, there is a lack of systematic approaches to guide implementation in government health systems. The objective of this study was to address this gap by employing the Replicating Effective Programs (REP) framework to guide contextualization of a psychological treatment in the Uganda public health system for caregivers of children affected by nodding syndrome, a neuropsychiatric disorder endemic to Sub-Saharan Africa associated with high morbidity and disability.

METHODS: To contextualize a psychological treatment, we followed the four components of the REP framework: pre-conditions, pre-implementation, implementation ...


The Role Of Communities In Mental Health Care In Low- And Middle-Income Countries: A Meta-Review Of Components And Competencies., Brandon A Kohrt, Laura Asher, Anvita Bhardwaj, Mina Fazel, Mark J D Jordans, Byamah B Mutamba, Abhijit Nadkarni, Gloria A Pedersen, Daisy R Singla, Vikram Patel 2018 George Washington University

The Role Of Communities In Mental Health Care In Low- And Middle-Income Countries: A Meta-Review Of Components And Competencies., Brandon A Kohrt, Laura Asher, Anvita Bhardwaj, Mina Fazel, Mark J D Jordans, Byamah B Mutamba, Abhijit Nadkarni, Gloria A Pedersen, Daisy R Singla, Vikram Patel

Psychiatry and Behavioral Sciences Faculty Publications

Abstract

Community-based mental health services are emphasized in the World Health Organization’s Mental Health Action Plan, the World Bank’s Disease Control Priorities, and the Action Plan of the World Psychiatric Association. There is increasing evidence for effectiveness of mental health interventions delivered by non-specialists in community platforms in low- and middle-income countries (LMIC). However, the role of community components has yet to be summarized. Our objective was to map community interventions in LMIC, identify competencies for community-based providers, and highlight research gaps. Using a review-of-reviews strategy, we identified 23 reviews for the narrative synthesis. Motivations to employ community ...


Why Pregnant Women With Depression Often Slip Through The Cracks, Tiffany A. Moore Simas, Nancy Byatt 2018 University of Massachusetts Medical School

Why Pregnant Women With Depression Often Slip Through The Cracks, Tiffany A. Moore Simas, Nancy Byatt

Psychiatry Publications and Presentations

One in seven women experience depression during pregnancy and after they give birth. This article explains how a model the authors created in Massachusetts to ensure that women with depression get the help they need is being implemented in other states.


Common And Dissociable Neural Activity After Mindfulness-Based Stress Reduction And Relaxation Response Programs, Gunes Sevinc, Britta K. Holzel, Javeria Hashmi, Jonathan Greenberg, Adrienne McCallister, Michael Treadway, Marissa L. Schneider, Jeffery A. Dusek, James F. Carmody, Sara W. Lazar 2018 Harvard Medical School

Common And Dissociable Neural Activity After Mindfulness-Based Stress Reduction And Relaxation Response Programs, Gunes Sevinc, Britta K. Holzel, Javeria Hashmi, Jonathan Greenberg, Adrienne Mccallister, Michael Treadway, Marissa L. Schneider, Jeffery A. Dusek, James F. Carmody, Sara W. Lazar

Open Access Articles

OBJECTIVE: We investigated common and dissociable neural and psychological correlates of two widely used meditation-based stress reduction programs.

METHODS: Participants were randomized to the Relaxation Response (RR; n = 18; 56% female) or the Mindfulness-Based Stress Reduction (MBSR; n = 16; 56% female) programs. Both programs use a "bodyscan" meditation; however, the RR program explicitly emphasizes physical relaxation during this practice, whereas the MBSR program emphasizes mindful awareness with no explicit relaxation instructions. After the programs, neural activity during the respective meditation was investigated using functional magnetic resonance imaging.

RESULTS: Both programs were associated with reduced stress (for RR, from 14.1 ...


Continue, Adjust, Or Stop Antipsychotic Medication: Developing And User Testing An Encounter Decision Aid For People With First-Episode And Long-Term Psychosis, Yaara Zisman-Ilani, David Shern, Patricia Deegan, Julie Kreyenbuhl, Lisa Dixon, Robert Drake, Manish Mishra, Ksenia Gorbenko, Glyn Elwyn 2018 College of Public Health, Temple University

Continue, Adjust, Or Stop Antipsychotic Medication: Developing And User Testing An Encounter Decision Aid For People With First-Episode And Long-Term Psychosis, Yaara Zisman-Ilani, David Shern, Patricia Deegan, Julie Kreyenbuhl, Lisa Dixon, Robert Drake, Manish Mishra, Ksenia Gorbenko, Glyn Elwyn

Open Dartmouth: Faculty Open Access Articles

People with psychosis struggle with decisions about their use of antipsychotics. They often want to reduce the dose or stop, while facing uncertainty regarding the effects these decisions will have on their treatment and recovery. They may also fear raising this issue with clinicians. The purpose of this study was to develop and test a shared decision making (SDM) tool to support patients and clinicians in making decisions about antipsychotics.


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