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An Atypical Presentation Of Neuroleptic Malignant Syndrome, Rudy Forte MD, Shiwani Kamath MD, Debra Angelo MD, Johnathan Frunzi MD 2020 HCA Healthcare

An Atypical Presentation Of Neuroleptic Malignant Syndrome, Rudy Forte Md, Shiwani Kamath Md, Debra Angelo Md, Johnathan Frunzi Md

West Florida Division

Neuroleptic Malignant Syndrome (NMS) is a rare, but potentially life threatening condition associated with dopamine blockade, particularly first-generation antipsychotics. The complex pathophysiology of NMS remains somewhat unclear and debatable as the symptoms are not fully explained by dopamine blockade alone.1 D2 dopamine receptor antagonism remains responsible for most cases of NMS, however a few cases have been reported in which little to no D2 blockade activity was present.1

This poster is about an atypical presentation of NMS.


New Onset Psychosis Secondary To Neurosyphilis, Lauren Angela DeMarco DO, Samantha Linda Jane Vu DO, Francis Butler MD, Nihal Shah MD 2020 HCA Healthcare

New Onset Psychosis Secondary To Neurosyphilis, Lauren Angela Demarco Do, Samantha Linda Jane Vu Do, Francis Butler Md, Nihal Shah Md

West Florida Division

Syphilis is a highly contagious sexually transmitted infection (STI) caused by the spirochetal bacterium Treponema pallidum. Transmission occurs through direct contact of painless ulcerative lesions, chancres, located on the genitalia (penis, labia) and oral mucosa. Neurosyphilis is any involvement of the central nervous systems (brain, meninges, or spinal cord) by the bacterium.


Acute Disseminated Encephalomyelitis, Ashan T. Hatharasinghe, Hossein Akhondi, Don Pepito 2020 Sunrise Health GME Consortium

Acute Disseminated Encephalomyelitis, Ashan T. Hatharasinghe, Hossein Akhondi, Don Pepito

HCA Healthcare Journal of Medicine

Introduction: Acute Disseminated Encephalomyelitis (ADEM) is a rare autoimmune demyelinating disorder of the central nervous system. Clinical manifestations include encephalopathy, motor deficits, ataxia, and meningeal signs. In most cases, ADEM is preceded by either vaccination or viral illness. Here, we present a case with neither of the two predisposing elements.

Discussion: A 28-year-old Hispanic female presenting with substance use and suicidal ideation was placed on an involuntary psychiatric hold, started on olanzapine and scheduled for a psychiatric facility transfer. The following day, she was noted to have neurological deficits when ambulating. Computed tomography of the brain showed a right frontal ...


Association Of Affect Dynamics And Psychotic Symptoms In Clinical High Risk And Early Course Psychosis, K A. Woodberry, W Cook, K Elacqua, K A. Johnson, K Powers, M Graham, A Cloutier, T Twhigg, D Robbins, R Mesholam-Gately 2020 Maine Medical Center

Association Of Affect Dynamics And Psychotic Symptoms In Clinical High Risk And Early Course Psychosis, K A. Woodberry, W Cook, K Elacqua, K A. Johnson, K Powers, M Graham, A Cloutier, T Twhigg, D Robbins, R Mesholam-Gately

Costas T. Lambrew Research Retreat 2020

Purpose: Although there is recent skepticism about whether affect dynamics offer added value over mean levels of negative affect in differentiating between individuals, there has been little research examining the relationship of affect variability (AV) and psychotic symptoms within individuals (day-to-day). The purpose of these analyses was to explore the relationship of affect dynamics to psychotic experiences in individuals at clinical high risk (CHR) for psychosis or within five years of the onset of a psychotic disorder (PSY).

Methods: We collected experience-sampling data from CHR and PSY patients ages 15-25. Up to 6 times per day, participants rated positive and ...


Valbenazine Has A Small But Meaningful Benefit For Tardive Dyskinesia, Joseph Friedli, Ryan Quick, Reem Sobh, Samantha Cowing 2020 Wayne State University School of Medicine

Valbenazine Has A Small But Meaningful Benefit For Tardive Dyskinesia, Joseph Friedli, Ryan Quick, Reem Sobh, Samantha Cowing

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of

Hauser RA, Factor SA, Marder SR, et al. KINECT 3: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Trial of Valbenazine for Tardive Dyskinesia. Am J Psychiatry. 2017;174(5):476-484. https://doi.org/10.1176/appi.ajp.2017.16091037

and

Factor SA, Remington G, Comella CL, et al. The Effects of Valbenazine in Participants with Tardive Dyskinesia: Results of the 1-Year KINECT 3 Extension Study. J Clin Psychiatry. 2017;78(9):1344-1350. https://doi.org/10.4088/JCP.17m11777

exploring the efficacy of a newer therapy for tardive dyskinesia, and describing recommendations for a ...


Consciousness Level Determination Of Red Meat Consumption Of Pregnant Women, Giresun/Turkey Province, Duygu Balpetek Külcü, Özge Cağcağ Yolcu 2020 DEPARTMENT OF FOOD ENGINEERING, GIRESUN UNIVERSITY, 28200, GIRESUN, TURKEY, DUYGU.BALPETEK@GIRESUN.EDU.TR

Consciousness Level Determination Of Red Meat Consumption Of Pregnant Women, Giresun/Turkey Province, Duygu Balpetek Külcü, Özge Cağcağ Yolcu

Journal of Mind and Medical Sciences

In this study, meat consumption and the nutritional status of pregnant women living in Giresun province of Turkey were investigated. The study was carried out at Giresun University, the Maternity and Pediatrics Training and Research Hospital between February-March 2019. The study group consisted of 218 pregnant women aged 18 to 49 years, who benefited from polyclinic services and agreed to participate in the survey. A questionnaire consisting of 12 questions was used, and the findings were evaluated using SPSS to generate descriptive statistics and t-tests or ANOVAs. The majority of participants stated that red meat is beneficial during pregnancy (71 ...


Impact Of Rational And Experiential Thinking Styles On Interpersonal Conflict Resolution Among Young Adults, Ayesha Rafique, Hania Habib, Fariha Abdul Rehman, Shabnam Arshi 2020 INSTITUTE OF PROFESSIONAL PSYCHOLOGY, BAHRIA UNIVERSITY- KARACHI CAMPUS, KARACHI, PAKISTAN

Impact Of Rational And Experiential Thinking Styles On Interpersonal Conflict Resolution Among Young Adults, Ayesha Rafique, Hania Habib, Fariha Abdul Rehman, Shabnam Arshi

Journal of Mind and Medical Sciences

This research aimed to find the relationship between thinking styles (rational or experiential) and interpersonal conflict resolution (ICR) in young adults. A sample of 99 females and 103 males, age range 18 to 40 years, was selected via convenient and snow-ball sampling. Thinking styles were assessed using Rational-Experiential Inventory-40, and ICR was measured using Conflict Resolution Questionnaire. Regression analysis was used to predict ICR based on thinking style covariates and several relevant demographic covariates, including gender and family birth order. Rational thinking style (RTS) was most prevalent among young adults and was the strongest predictor of ICR. In addition, gender ...


Compassion And Suppression In Caregivers: Twin Masks Of Tragedy And Joy Of Caring, Emanuele Maria Merlo, Sean M. McNabney, Fabio Frisone, Federica Sicari, Mihai Paunica, Catalina Motofei, Salvatore Settineri 2020 DEPARTMENT OF COGNITIVE SCIENCES, PSYCHOLOGY, EDUCATIONAL AND CULTURAL STUDIES (COSPECS), UNIVERSITY OF MESSINA, ITALY

Compassion And Suppression In Caregivers: Twin Masks Of Tragedy And Joy Of Caring, Emanuele Maria Merlo, Sean M. Mcnabney, Fabio Frisone, Federica Sicari, Mihai Paunica, Catalina Motofei, Salvatore Settineri

Journal of Mind and Medical Sciences

Background: Compassionate caregiving is a critical skill for workers among the helping professions, but the degree of empathy required by caregivers can place high demands on their mental and emotional resources. While many professionals employ successful coping strategies to mitigate these stressors, others experience compassion fatigue or burnout from emotional exhaustion. The objective of this research was to evaluate the relationships between caregivers’ demographic/career variables, compassion satisfaction, compassion fatigue, and psychodynamic defense mechanisms such as suppression, repressive function, regression in the service of the Ego, and rationalization. Methods: Participants were 250 caregivers with 178 (71,2%) women and 72 ...


Underactive Bladder - An Underestimated Entity, Spinu Arsenie Dan, Ovidiu Gabriel Bratu, Dragos Radu Marcu, Adina Elena Stanciu, Florentina Gherghiceanu, Florentina Ionita-Radu, Simona Bungau, Ana Maria Alexandra Stanescu, Dan Mischianu 2020 CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY, BUCHAREST, ROMANIA

Underactive Bladder - An Underestimated Entity, Spinu Arsenie Dan, Ovidiu Gabriel Bratu, Dragos Radu Marcu, Adina Elena Stanciu, Florentina Gherghiceanu, Florentina Ionita-Radu, Simona Bungau, Ana Maria Alexandra Stanescu, Dan Mischianu

Journal of Mind and Medical Sciences

Introduction. The concept of underactive bladder is relatively new. Currently there is no generally accepted definition of this pathology. Diagnosis depends on urodynamic findings, and symptoms are usually rare and intricated with the symptoms of other urinary pathology.

Matherials and methods. This review examines the current literature on underactive bladder regarding pathology, definition, diagnosis, current guidelines, and any further potential medical developments.

Conclusions. Underactive bladder is a poorly understood pathologic condition. Only since 2002 has there been any consensus regarding the definition. The diagnosis relies only on urodynamics; clinical diagnosis is a challenge even for a consultant; and treatment does ...


The Role Of Biotransformation Processes In Mediating Interactions Between Psychotropic Drugs And Natural Products, Nicolae Bacinschi, Ina Pogonea, Lilia Podgurschi, Maria Mihalachi-Anghel, Emil Ștefănescu, Bogdan Socea, Marin Chianu 2020 NICOLAE TESTEMITANU STATE UNIVERSITY OF MEDICINE AND PHARMACY, FACULTY OF MEDICINE, DEPARTMENT OF PHARMACOLOGY AND CLINICAL PHARMACOLOGY, CHIȘINĂU, REPUBLIC OF MOLDOVA.

The Role Of Biotransformation Processes In Mediating Interactions Between Psychotropic Drugs And Natural Products, Nicolae Bacinschi, Ina Pogonea, Lilia Podgurschi, Maria Mihalachi-Anghel, Emil Ștefănescu, Bogdan Socea, Marin Chianu

Journal of Mind and Medical Sciences

Many patients are not aware that natural products such as fruit juices or plant infusions can cause significant interactions with several drugs, some of which can be dangerous, especially when the medical treatment is for neurological or psychiatric disorders. Among the most predisposed for interacting with drugs are citric juices, particularly grapefruit and plant infusions, especially St John`s wort (Hypericum perforatum). Understanding the mechanism and the frequency of this type of interaction helps to avoid it. The goal of this research was to identify and summarize the most relevant reports on interactions between psychotropic drugs and natural beverages, in ...


Development Of An Early-Warning System For High-Risk Patients For Suicide Attempt Using Deep Learning And Electronic Health Records, Le Zheng, Alex N. Sabo, Liliana Markovic, Xuefeng B. Ling 2020 Stanford University

Development Of An Early-Warning System For High-Risk Patients For Suicide Attempt Using Deep Learning And Electronic Health Records, Le Zheng, Alex N. Sabo, Liliana Markovic, Xuefeng B. Ling

Open Access Articles

Suicide is the tenth leading cause of death in the United States (US). An early-warning system (EWS) for suicide attempt could prove valuable for identifying those at risk of suicide attempts, and analyzing the contribution of repeated attempts to the risk of eventual death by suicide. In this study we sought to develop an EWS for high-risk suicide attempt patients through the development of a population-based risk stratification surveillance system. Advanced machine-learning algorithms and deep neural networks were utilized to build models with the data from electronic health records (EHRs). A final risk score was calculated for each individual and ...


Effects Of Oral, Smoked, And Vaporized Cannabis On Endocrine Pathways Related To Appetite And Metabolism: A Randomized, Double-Blind, Placebo-Controlled, Human Laboratory Study., Mehdi Farokhnia, Gray R McDiarmid, Matthew N Newmeyer, Vikas Munjal, Osama A Abulseoud, Marilyn A Huestis, Lorenzo Leggio 2020 National Institutes of Health, Johns Hopkins University

Effects Of Oral, Smoked, And Vaporized Cannabis On Endocrine Pathways Related To Appetite And Metabolism: A Randomized, Double-Blind, Placebo-Controlled, Human Laboratory Study., Mehdi Farokhnia, Gray R Mcdiarmid, Matthew N Newmeyer, Vikas Munjal, Osama A Abulseoud, Marilyn A Huestis, Lorenzo Leggio

Institute of Emerging Health Professions Faculty Papers

As perspectives on cannabis continue to shift, understanding the physiological and behavioral effects of cannabis use is of paramount importance. Previous data suggest that cannabis use influences food intake, appetite, and metabolism, yet human research in this regard remains scant. The present study investigated the effects of cannabis administration, via different routes, on peripheral concentrations of appetitive and metabolic hormones in a sample of cannabis users. This was a randomized, crossover, double-blind, placebo-controlled study. Twenty participants underwent four experimental sessions during which oral cannabis, smoked cannabis, vaporized cannabis, or placebo was administered. Active compounds contained 6.9 ± 0.95% (~50 ...


Hyperammonemic Encephalopathy With Triphasic Waves: A Case, Brian Birdsong MD, Brielle Marks MD, Rishim Jayswal MD, Adeel Rahman 2020 HCA Healthcare

Hyperammonemic Encephalopathy With Triphasic Waves: A Case, Brian Birdsong Md, Brielle Marks Md, Rishim Jayswal Md, Adeel Rahman

Psychiatry

No abstract provided.


Famille+: A Multifamily Group Program For Families With Parental Depression, Genevieve Piche, Aude Villatte, Rima Habib, Kelly Vetri, William Beardslee 2020 Universite du Quebec en Outaouais

Famille+: A Multifamily Group Program For Families With Parental Depression, Genevieve Piche, Aude Villatte, Rima Habib, Kelly Vetri, William Beardslee

Journal of Parent and Family Mental Health

Children living with a parent with a depressive disorder are at higher risk for low adaptive functioning, in terms of social, academic, emotional, and mental health problems (Reupert, Maybery & Kowalenko, 2012).This brief describes FAMILLE+, a multifamily group program for parents with major depressive disorder and their 7 to 11 years old children. Its purpose is to prevent the development of mental health problems in children and to promote family resilience and was specifically adapted to fit the children's developmental (cognitive, attentional and socio-emotional) abilities.


Psychiatric Illness And Regression In Individuals With Phelan-Mcdermid Syndrome, Teresa M. Kohlenberg, M. Pilar Trelles, Brittany McLarney, Catalina Betancur, Audrey Thurm, Alexander Kolevzon 2020 University of Massachusetts Medical School

Psychiatric Illness And Regression In Individuals With Phelan-Mcdermid Syndrome, Teresa M. Kohlenberg, M. Pilar Trelles, Brittany Mclarney, Catalina Betancur, Audrey Thurm, Alexander Kolevzon

Open Access Articles

BACKGROUND: Phelan-McDermid syndrome (PMS) is a genetic condition characterized by intellectual disability, speech and language deficits, hypotonia, autism spectrum disorder, and epilepsy. PMS is caused by 22q13.33 deletions or mutations affecting SHANK3, which codes for a critical scaffolding protein in excitatory synapses. SHANK3 variants are also known to be associated with an increased risk for regression, as well as for psychiatric disorders, including bipolar disorder and catatonia. This study aimed to further describe these phenomena in PMS and to explore any relationship between psychiatric illness and regression after early childhood.

METHODS: Thirty-eight people with PMS were recruited to this ...


Transcriptomics Of Gabra4 Knockout Mice Reveals Common Nmdar Pathways Underlying Autism, Memory, And Epilepsy, Cuixia Fan, Yue Gao, Guanmei Liang, Lang Huang, Jing Wang, Xiaoxue Yang, Yiwu Shi, Ursula C. Drager, Mei Zhong, Tian-Ming Gao, Xinping Yang 2020 Southern Medical University

Transcriptomics Of Gabra4 Knockout Mice Reveals Common Nmdar Pathways Underlying Autism, Memory, And Epilepsy, Cuixia Fan, Yue Gao, Guanmei Liang, Lang Huang, Jing Wang, Xiaoxue Yang, Yiwu Shi, Ursula C. Drager, Mei Zhong, Tian-Ming Gao, Xinping Yang

Open Access Articles

Autism spectrum disorder (ASD) is a neuronal developmental disorder with impaired social interaction and communication, often with abnormal intelligence and comorbidity with epilepsy. Disturbances in synaptic transmission, including the GABAergic, glutamatergic, and serotonergic systems, are known to be involved in the pathogenesis of this disorder, yet we do not know if there is a common molecular mechanism. As mutations in the GABAergic receptor subunit gene GABRA4 are reported in patients with ASD, we eliminated the Gabra4 gene in mice and found that the Gabra4 knockout mice showed autistic-like behavior, enhanced spatial memory, and attenuated susceptibility to pentylenetetrazol-induced seizures, a constellation ...


Treatment And Management Of Depression Symptoms In Pregnant Veterans: Varying Experiences Of Mental Health Care In The Prenatal Period, Aimee Kroll-Desrosiers, Sybil L. Crawford, Tiffany A. Moore Simas, Melissa A. Clark, Kristin M. Mattocks 2020 University of Massachusetts Medical School

Treatment And Management Of Depression Symptoms In Pregnant Veterans: Varying Experiences Of Mental Health Care In The Prenatal Period, Aimee Kroll-Desrosiers, Sybil L. Crawford, Tiffany A. Moore Simas, Melissa A. Clark, Kristin M. Mattocks

Population and Quantitative Health Sciences Publications

Depression screening is recommended for all pregnant veterans; however, little is known on how often symptomatic women receive care, how depression treatment presents in practice, and whether women veterans are utilizing treatment during the appreciable perinatal period. Our sample included 142 pregnant veterans from 15 Veterans Health Administration (VA) medical facilities with Edinburgh Postnatal Depression Scale (EPDS) scores >/=10. Sociodemographic characteristics, military service, health utilization, and pregnancy related factors were collected as part of a telephone survey. A majority of our sample (70%) had 1 or more mental health visits or antidepressant prescriptions during pregnancy. Women with a history of ...


A Phantom Of The Past: Withdrawal From Meprobamate Presenting With Focal Seizures., Thomas M. Zink, John E. Erickson 2020 Tufts University School of Medicine; Maine Medical Center

A Phantom Of The Past: Withdrawal From Meprobamate Presenting With Focal Seizures., Thomas M. Zink, John E. Erickson

Journal of Maine Medical Center

Introduction: Meprobamate (Miltown, Equinil) is a sedative-hypnotic medication that first gained popularity as an anxiolytic and later as a muscle relaxant. It is a major metabolite of the more commonly used muscle relaxant carisoprodol (Soma). In vitro and electroencephalogram studies demonstrated that meprobamate modulates gama-aminobutyric acid (GABA) receptors, similar to barbiturates. Withdrawal from meprobamate manifests in symptoms ranging from mild anxiety to severe autonomic instability and death. Meprobamate is rarely prescribed, but is still given to a small subset of elderly patients.

Clinical findings: In this case of meprobamate withdrawal, the patient initially displayed altered mental status and recurrent seizures ...


Anxiety And Depressive Symptoms Pre-Trauma As A Predictor Of Dissociative Symptoms Post-Trauma – An Aurora Study, Vishal Swaminathan 2020 Thomas Jefferson University

Anxiety And Depressive Symptoms Pre-Trauma As A Predictor Of Dissociative Symptoms Post-Trauma – An Aurora Study, Vishal Swaminathan

Phase 1

Introduction: Increased states of anxiety or depression may lead to increased occurrences of dissociative behavior, justifying the need to validate pre-traumatic cognitive states as a predictor of dissociation post-trauma. Early prediction can lead to medical intervention for high-risk patients and prevent potential adverse sequalae. The AURORA Study evaluates biomarkers and neuropsychological sequelae in patients immediately following traumatic events. We predict patients who suffered from depressive symptoms and anxiety prior to the traumatic event will experience increased dissociative symptoms post-trauma.

Methods: This study includes survey data collected at ED’s from survivors (n = 666) of traumatic motorized vehicle collisions (MVC) at ...


The Efficacy Of Yoga As An Adjunctive Therapy To Standard Multidisciplinary Care In The Treatment Of Female Patients Presenting With Cognitive Eating Disorder Symptoms, Cassidy Nagle 2020 Arcadia University

The Efficacy Of Yoga As An Adjunctive Therapy To Standard Multidisciplinary Care In The Treatment Of Female Patients Presenting With Cognitive Eating Disorder Symptoms, Cassidy Nagle

Capstone Showcase

Introduction: Current treatment of patients exhibiting cognitive eating disorder symptoms is standard multidisciplinary care (SMDC) involving behavioral therapy, medical management and dietetics. Because these symptoms often persist or relapse despite treatment, research has begun to explore adjunctive therapies like yoga for this population. This review will explore seven studies in order to analyze the effect of yoga (I) on cognitive eating disorder symptoms (O) in teenage and adult females (P) when added to SMDC compared to symptom reduction with SMDC alone (C).

Methods: A literature search was conducted in PubMed, Academic Search Ultimate and Google Scholar starting November 2018. Seven ...


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