Osteopathic Medicine and Osteopathy Commons^™

Melatonin-Micronutrients Osteopenia Treatment Study (Mots): A Translational Study Assessing The Effects Of Melatonin, Strontium Citrate, Vitamin D3 And Vitamin K2 On Bone Density, Bone Turnover Markers And Health-Related Quality Of Life In Postmenopausal Osteopenic Women Following A One-Year Double-Blind Randomized Placebo-Controlled Trial And On Osteoblast-Osteoclast Co-Cultures, Sifat Maria

Electronic Theses and Dissertations

Objective: The purpose of this study was to assess if a novel combination of melatonin and three other natural bone-aiding micronutrients: strontium citrate, vitamins D₃ and K₂ (MSDK) could improve bone health by modulating the activity of osteoblasts and osteoclasts in favor of balanced bone remodeling and by improving the overall health-related quality of life in postmenopausal osteopenic women.

Methods: The Melatonin-micronutrients Osteopenia Treatment Study (MOTS) is a translational research study that used both clinical and in vitro approaches to assess the efficacy of MSDK on bone health in women and to identify potential mechanisms for its effects ...

Osteopathic Manipulative Medicine In Pregnancy, Xinhua Chen Md, Msce, Maria Nguyen Do, Sophia Vogiatzidakis Do

Stratford Campus Research Day

Women experience physiologic and structural changes during pregnancy. Osteopathic manipulative medicine (OMM) involves the examination of the whole patient, including body, mind, and spirit. This involves treatment of any stresses placed on the body, including the structural changes in the maternal body. Clinical studies thus far on OMM in pregnancy have shown when used during pregnancy, it improves musculoskeletal pain such as low back pain, and may positively affect some labor and delivery outcomes. The purpose of this study was to evaluate the effectiveness of OMM during pregnancy in reducing the rate of cesarean section and several other labor and ...

Maps-Snma Shad.O.W D.O. Day Rowan Som Pipeline Program: A Pilot Study, Taiwo Ajumobi, K. Millar, Hina Mujadad, Yessica Manzo, Tashawni Channer, Cassandra Ramirez, Nkechiyere Eboka, Paula Watkins Mas, Linda Boyd Do

Stratford Campus Research Day

Prior to being a medical student, a majority of pre-medical students have not encountered the course load intensity, academic rigor, and time management required by a medical school curriculum. Diversifying the workforce has been shown to have benefits, especially at the micro or patient level, since having racial or ethnic concordance between providers and patients has been associated with increased levels of satisfaction and improvements in certain clinical outcomes. The number of MDs increased to 841,321 or 91.8% versus 72,961 DOs or 8.0% creating the need for minorities to be knowledgeable of both MD and DO ...

2018 University Of New England College Of Osteopathic Medicine Fellowship Recipients, University Of New England College Of Osteopathic Medicine

Peter Morgane Research Fellowships

2018 recipients of the University of New England College of Osteopathic Medicine's Peter Morgane Research Fellowship.

Vital Signs Of U.S. Osteopathic Medical Residency Programs Pivoting To Single Accreditation Standards, Timothy S. Novak

Graduate Theses and Dissertations

Osteopathic physician (D.O.) residency programs that do not achieve accreditation under the new Single Accreditation System (SAS) standards by June 30, 2020 will lose access to their share of more than $9,000,000,000 of public tax dollars. This U.S. Centers for Medicare & Medicaid Services (CMS) funding helps sponsoring institutions cover direct and indirect resident physician training expenses. A significant financial burden would then be shifted to marginal costs of the residency program’s sponsoring institution in the absence of CMS funding. The sponsoring institution’s ability or willingness to bare these costs occurs during a time ...

The Farnesoid X Receptor Negatively Regulates Osteoclastogenesis In Bone Remodeling And Pathological Bone Loss, Ting Zheng, Ju-Hee Kang, Jung-Sun Sim, Jung-Woo Kim, Jeong-Tae Koh, Chan Soo Shin, Hyungsik Lim, Mijung Yim

Publications and Research

Farnesoid X receptor (FXR, NR1H4) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. Since the role of FXR in osteoclast differentiation remains ill-defined, we investigated the biological function of FXR on osteoclastogenesis, using FXR-deficient mice. We demonstrated that FXR deficiency increases osteoclast formation in vitro and in vivo. First, FXR deficiency was found to accelerate osteoclast formation via down-regulation of c-Jun N-terminal kinase (JNK) 1/2 expression. Increased expression of peroxisome proliferator-activated receptor (PPAR)γ and peroxisome proliferator-activated receptor gamma coactivator 1 (PGC- 1)β seems to mediate the pro-osteoclastogenic effect of FXR deficiency via the ...

The Concurrent Use Of Lumbar Total Disc Arthroplasty And Anterior Lumbar Interbody Fusion: The Lumbar Hybrid Procedure For The Treatment Of Multi-Level Symptomatic Degenerative Disc Disease A Prospective Study, Matthew Scott-Young, Laurence Mcentee, Ben Schram, Evelyne Rathbone, Wayne Hing, David Nielsen

Wayne Hing

STUDY DESIGN: A prospective study. OBJECTIVE: The aim of this paper is to evaluate clinical and patient outcomes post combined Total Disc Arthroplasty (TDA) and Anterior Lumbar Interbody Fusion (ALIF), known as hybrid surgery for the treatment of multi-level symptomatic degenerative disc disease (DDD). SUMMARY OF BACKGROUND DATA: Class I studies comparing the treatment of one level lumbar DDD with TDA and ALIF have confirmed the effectiveness of those treatments through clinical and patient outcomes. While the success of single level disease is well documented, the evidence relating to the treatment of multi-level DDD with these modalities is emerging. With ...

The Concurrent Use Of Lumbar Total Disc Arthroplasty And Anterior Lumbar Interbody Fusion: The Lumbar Hybrid Procedure For The Treatment Of Multi-Level Symptomatic Degenerative Disc Disease A Prospective Study, Matthew Scott-Young, Laurence Mcentee, Ben Schram, Evelyne Rathbone, Wayne Hing, David Nielsen

Ben Schram

STUDY DESIGN: A prospective study. OBJECTIVE: The aim of this paper is to evaluate clinical and patient outcomes post combined Total Disc Arthroplasty (TDA) and Anterior Lumbar Interbody Fusion (ALIF), known as hybrid surgery for the treatment of multi-level symptomatic degenerative disc disease (DDD). SUMMARY OF BACKGROUND DATA: Class I studies comparing the treatment of one level lumbar DDD with TDA and ALIF have confirmed the effectiveness of those treatments through clinical and patient outcomes. While the success of single level disease is well documented, the evidence relating to the treatment of multi-level DDD with these modalities is emerging. With ...

The Concurrent Use Of Lumbar Total Disc Arthroplasty And Anterior Lumbar Interbody Fusion: The Lumbar Hybrid Procedure For The Treatment Of Multi-Level Symptomatic Degenerative Disc Disease A Prospective Study, Matthew Scott-Young, Laurence Mcentee, Ben Schram, Evelyne Rathbone, Wayne Hing, David Nielsen

Faculty of Health Sciences & Medicine Publications

STUDY DESIGN:

A prospective study.

OBJECTIVE:

The aim of this paper is to evaluate clinical and patient outcomes post combined Total Disc Arthroplasty (TDA) and Anterior Lumbar Interbody Fusion (ALIF), known as hybrid surgery for the treatment of multi-level symptomatic degenerative disc disease (DDD).

SUMMARY OF BACKGROUND DATA:

Class I studies comparing the treatment of one level lumbar DDD with TDA and ALIF have confirmed the effectiveness of those treatments through clinical and patient outcomes. While the success of single level disease is well documented, the evidence relating to the treatment of multi-level DDD with these modalities is emerging. With ...

Is Home-Based, High-Intensity Interval Training Cycling Feasible And Safe For Patients With Knee Osteoarthritis? Study Protocol For A Randomized Pilot Study, Justin W L Keogh, Josephine Grigg, Christopher J Vertullo

Justin Keogh

BACKGROUND:

Osteoarthritis (OA) is a degenerative joint disease affecting the knee joint of many middle-aged and older adults. As OA symptoms typically involve knee pain and stiffness, individuals with knee OA are often insufficiently physically active, have low levels of physical function, and are at increased risk of other comorbidities and reduced quality of life. While moderate-intensity continuous training (MICT) cycling is often recommended, little is known about the feasibility, safety, and benefits of high-intensity interval training (HIIT) cycling for this population, even though the feasibility, safety, and benefits of HIIT have been demonstrated in other chronic disease groups.

PURPOSE ...

2017 University Of New England College Of Osteopathic Medicine Fellowship Recipients, University Of New England College Of Osteopathic Medicine

Peter Morgane Research Fellowships

2017 recipients of the University of New England College of Osteopathic Medicine's Peter Morgane Research Fellowship.

Is Home-Based, High-Intensity Interval Training Cycling Feasible And Safe For Patients With Knee Osteoarthritis? Study Protocol For A Randomized Pilot Study, Justin W L Keogh, Josephine Grigg, Christopher J Vertullo

Faculty of Health Sciences & Medicine Publications

BACKGROUND:

Osteoarthritis (OA) is a degenerative joint disease affecting the knee joint of many middle-aged and older adults. As OA symptoms typically involve knee pain and stiffness, individuals with knee OA are often insufficiently physically active, have low levels of physical function, and are at increased risk of other comorbidities and reduced quality of life. While moderate-intensity continuous training (MICT) cycling is often recommended, little is known about the feasibility, safety, and benefits of high-intensity interval training (HIIT) cycling for this population, even though the feasibility, safety, and benefits of HIIT have been demonstrated in other chronic disease groups.

PURPOSE ...

2017 Founders' Day, Philadelphia College Of Osteopathic Medicine

Founders Day Programs

The 2017 Founders Day Alumni Association Certificate of Honor Recipient was Dana C. Shaffer (DO '85). The OJ Snyder Memorial Medal recipient was Vincent G. Lobo (DO '65). The Philadelphia Campus Mason W. Pressly Memorial Medal Recipient was Anna Elisa Muzio (DO '17). The Georgia campus Mason W. Pressly Memorial Medal Recipient was Matthew Shelnutt (DO '17).

Bone Tissue Material Properties Are Altered In Chronic Kidney Disease To Lower Fracture Resistance-Determining Bone Quality, Chelsea Marie Heveran

Mechanical Engineering Graduate Theses & Dissertations

Chronic kidney disease (CKD) is associated with a clinically-observed increase in bone fragility, yet the specific changes to fracture resistance-determining bone quality are not understood. CKD disrupts systemic mineral homeostasis and alters bone turnover. Thus, it was hypothesized that CKD deleteriously affects tissue-scale material properties. In Aim 1, mice with surgically-induced moderate CKD had diminished tissue-scale material properties, including mineral content and nanoindentation modulus, in bone formed during CKD compared with sham mice. Heterogeneity of microscale bone material was also altered with CKD. Next, CKD occurs most often in the elderly, yet geriatric patients with CKD have higher fracture risk ...

Developing An Evidence Base For Osteopathic Healthcare: An Exploration Of Osteopathic Healthcare To Inform The Design Of An Appropriate Methodology To Investigate Its Effectiveness, Paul James Orrock

Theses

Osteopathy is an international health service and osteopaths appear to utilise a range of therapeutic interventions, but there is a need for foundational research to establish a valid description of its intervention. Health services require an evidence base to establish a scientific foundation, to provide certainty to users and third party payers, to make comparisons with other services, to provide consumer choice and to influence practice. The process of establishing evidence has evolved alongside the development of scientific principles, and the current gold standard of evidence for healthcare is the randomised controlled trial. There are questions regarding whether this method ...

2016 University Of New England College Of Osteopathic Medicine Fellowship Recipients, University Of New England College Of Osteopathic Medicine

Peter Morgane Research Fellowships

2016 recipients of the University of New England College of Osteopathic Medicine's Peter Morgane Research Fellowship.

Spinal Muscular Atrophy Treatment Via Targeting Smn2 Catalytic Core, Ravindra N. Singh, Natalia N. Singh

Ravindra Singh

The present invention is directed to methods and compositions for blocking the effect of the intronic inhibitory splicing region of intron 7 of the SMN2 gene. The compositions and methods of the instant invention include short oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target sites in the SMN2 pre-mRNA, thereby modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript. The short target regions are 8-mers and 5-mers and also include the identification of a single nucleotide base that is essential for initiating a long distance stearic inhibitory interactions as well as novel targets distant from ...

Spinal Muscular Atrophy Treatment Via Targeting Smn2 Catalytic Core, Ravindra N. Singh, Natalia N. Singh

Ravindra Singh

The present invention is directed to methods and compositions for blocking the effect of the intronic inhibitory splicing region of intron 7 of the SMN2 gene. The compositions and methods of the instant invention include short oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target sites in the SMN2 pre-mRNA, thereby modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript. The short target regions are 8-mers and 5-mers and also include the identification of a single nucleotide base that is essential for initiating a long distance stearic inhibitory interactions as well as novel targets distant from ...

Bone Marrow Transplantation For Feline Mucopolysaccharidosis I, Norman Matthew Ellinwood, Marie-Anne Colle, Margaret A. Weil, Margret L. Casal, Charles H. Vite, Staci Wiemelt, Christopher W. Hasson, Thomas M. O'Malley, Xingxuan He, Ulana Prociuk, Lucie Verot, John R. Melniczek, Anne Lannon, Gustavo D. Aguirre, Van W. Knox, Sydney M. Evans, Marie T. Vanier, Edward H. Schuchman, Steven U. Walkley, Mark E. Haskins

Gustavo D. Aguirre, VMD, PhD

Severe mucopolysaccharidosis type I (MPS I) is a fatal neuropathic lysosomal storage disorder with significant skeletal involvement. Treatment involves bone marrow transplantation (BMT), and although effective, is suboptimal, due to treatment sequelae and residual disease. Improved approaches will need to be tested in animal models and compared to BMT. Herein we report on bone marrow transplantation to treat feline mucopolysaccharidosis I (MPS I). Five MPS I stably engrafted kittens, transplanted with unfractionated bone marrow (6.3 × 107–1.1 × 109 nucleated bone marrow cells per kilogram) were monitored for 13–37 months post-engraftment. The tissue total glycosaminoglycan (GAG) content was ...

2016 Founders' Day, Philadelphia College Of Osteopathic Medicine

Founders Day Programs

The 2016 Founders Day OJ Snyder Memorial Medal recipient was Richard Pascucci DO '75. The Philadelphia Campus Mason W. Pressly Memorial Medal Recipient was Zachary Herrman (DO '16). The Georgia campus Mason W. Pressly Memorial Medal Recipient was Jessica Mormando (DO '16).