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The Concurrent Use Of Lumbar Total Disc Arthroplasty And Anterior Lumbar Interbody Fusion: The Lumbar Hybrid Procedure For The Treatment Of Multi-Level Symptomatic Degenerative Disc Disease A Prospective Study, Matthew Scott-Young, Laurence McEntee, Ben Schram, Evelyne Rathbone, Wayne Hing, David Nielsen 2017 Bond University

The Concurrent Use Of Lumbar Total Disc Arthroplasty And Anterior Lumbar Interbody Fusion: The Lumbar Hybrid Procedure For The Treatment Of Multi-Level Symptomatic Degenerative Disc Disease A Prospective Study, Matthew Scott-Young, Laurence Mcentee, Ben Schram, Evelyne Rathbone, Wayne Hing, David Nielsen

Wayne Hing

STUDY DESIGN: A prospective study. OBJECTIVE: The aim of this paper is to evaluate clinical and patient outcomes post combined Total Disc Arthroplasty (TDA) and Anterior Lumbar Interbody Fusion (ALIF), known as hybrid surgery for the treatment of multi-level symptomatic degenerative disc disease (DDD). SUMMARY OF BACKGROUND DATA: Class I studies comparing the treatment of one level lumbar DDD with TDA and ALIF have confirmed the effectiveness of those treatments through clinical and patient outcomes. While the success of single level disease is well documented, the evidence relating to the treatment of multi-level DDD with these modalities is emerging. With ...


The Concurrent Use Of Lumbar Total Disc Arthroplasty And Anterior Lumbar Interbody Fusion: The Lumbar Hybrid Procedure For The Treatment Of Multi-Level Symptomatic Degenerative Disc Disease A Prospective Study, Matthew Scott-Young, Laurence McEntee, Ben Schram, Evelyne Rathbone, Wayne Hing, David Nielsen 2017 Bond University

The Concurrent Use Of Lumbar Total Disc Arthroplasty And Anterior Lumbar Interbody Fusion: The Lumbar Hybrid Procedure For The Treatment Of Multi-Level Symptomatic Degenerative Disc Disease A Prospective Study, Matthew Scott-Young, Laurence Mcentee, Ben Schram, Evelyne Rathbone, Wayne Hing, David Nielsen

Ben Schram

STUDY DESIGN: A prospective study. OBJECTIVE: The aim of this paper is to evaluate clinical and patient outcomes post combined Total Disc Arthroplasty (TDA) and Anterior Lumbar Interbody Fusion (ALIF), known as hybrid surgery for the treatment of multi-level symptomatic degenerative disc disease (DDD). SUMMARY OF BACKGROUND DATA: Class I studies comparing the treatment of one level lumbar DDD with TDA and ALIF have confirmed the effectiveness of those treatments through clinical and patient outcomes. While the success of single level disease is well documented, the evidence relating to the treatment of multi-level DDD with these modalities is emerging. With ...


The Concurrent Use Of Lumbar Total Disc Arthroplasty And Anterior Lumbar Interbody Fusion: The Lumbar Hybrid Procedure For The Treatment Of Multi-Level Symptomatic Degenerative Disc Disease A Prospective Study, Matthew Scott-Young, Laurence McEntee, Ben Schram, Evelyne Rathbone, Wayne Hing, David Nielsen 2017 Bond University

The Concurrent Use Of Lumbar Total Disc Arthroplasty And Anterior Lumbar Interbody Fusion: The Lumbar Hybrid Procedure For The Treatment Of Multi-Level Symptomatic Degenerative Disc Disease A Prospective Study, Matthew Scott-Young, Laurence Mcentee, Ben Schram, Evelyne Rathbone, Wayne Hing, David Nielsen

Faculty of Health Sciences & Medicine Publications

STUDY DESIGN:

A prospective study.

OBJECTIVE:

The aim of this paper is to evaluate clinical and patient outcomes post combined Total Disc Arthroplasty (TDA) and Anterior Lumbar Interbody Fusion (ALIF), known as hybrid surgery for the treatment of multi-level symptomatic degenerative disc disease (DDD).

SUMMARY OF BACKGROUND DATA:

Class I studies comparing the treatment of one level lumbar DDD with TDA and ALIF have confirmed the effectiveness of those treatments through clinical and patient outcomes. While the success of single level disease is well documented, the evidence relating to the treatment of multi-level DDD with these modalities is emerging. With ...


Is Home-Based, High-Intensity Interval Training Cycling Feasible And Safe For Patients With Knee Osteoarthritis? Study Protocol For A Randomized Pilot Study, Justin W L Keogh, Josephine Grigg, Christopher J Vertullo 2017 Bond University

Is Home-Based, High-Intensity Interval Training Cycling Feasible And Safe For Patients With Knee Osteoarthritis? Study Protocol For A Randomized Pilot Study, Justin W L Keogh, Josephine Grigg, Christopher J Vertullo

Justin Keogh

BACKGROUND:

Osteoarthritis (OA) is a degenerative joint disease affecting the knee joint of many middle-aged and older adults. As OA symptoms typically involve knee pain and stiffness, individuals with knee OA are often insufficiently physically active, have low levels of physical function, and are at increased risk of other comorbidities and reduced quality of life. While moderate-intensity continuous training (MICT) cycling is often recommended, little is known about the feasibility, safety, and benefits of high-intensity interval training (HIIT) cycling for this population, even though the feasibility, safety, and benefits of HIIT have been demonstrated in other chronic disease groups.

PURPOSE ...


Is Home-Based, High-Intensity Interval Training Cycling Feasible And Safe For Patients With Knee Osteoarthritis? Study Protocol For A Randomized Pilot Study, Justin W L Keogh, Josephine Grigg, Christopher J Vertullo 2017 Bond University

Is Home-Based, High-Intensity Interval Training Cycling Feasible And Safe For Patients With Knee Osteoarthritis? Study Protocol For A Randomized Pilot Study, Justin W L Keogh, Josephine Grigg, Christopher J Vertullo

Faculty of Health Sciences & Medicine Publications

BACKGROUND:

Osteoarthritis (OA) is a degenerative joint disease affecting the knee joint of many middle-aged and older adults. As OA symptoms typically involve knee pain and stiffness, individuals with knee OA are often insufficiently physically active, have low levels of physical function, and are at increased risk of other comorbidities and reduced quality of life. While moderate-intensity continuous training (MICT) cycling is often recommended, little is known about the feasibility, safety, and benefits of high-intensity interval training (HIIT) cycling for this population, even though the feasibility, safety, and benefits of HIIT have been demonstrated in other chronic disease groups.

PURPOSE ...


2017 Founders' Day, Philadelphia College of Osteopathic Medicine 2017 Philadelphia College of Osteopathic Medicine

2017 Founders' Day, Philadelphia College Of Osteopathic Medicine

Founders Day Programs

The 2017 Founders Day Alumni Association Certificate of Honor Recipient was Dana C. Shaffer (DO '85). The OJ Snyder Memorial Medal recipient was Vincent G. Lobo (DO '65). The Philadelphia Campus Mason W. Pressly Memorial Medal Recipient was Anna Elisa Muzio (DO '17). The Georgia campus Mason W. Pressly Memorial Medal Recipient was Matthew Shelnutt (DO '17).


Developing An Evidence Base For Osteopathic Healthcare: An Exploration Of Osteopathic Healthcare To Inform The Design Of An Appropriate Methodology To Investigate Its Effectiveness, Paul James Orrock 2017 Southern Cross University

Developing An Evidence Base For Osteopathic Healthcare: An Exploration Of Osteopathic Healthcare To Inform The Design Of An Appropriate Methodology To Investigate Its Effectiveness, Paul James Orrock

Theses

Osteopathy is an international health service and osteopaths appear to utilise a range of therapeutic interventions, but there is a need for foundational research to establish a valid description of its intervention. Health services require an evidence base to establish a scientific foundation, to provide certainty to users and third party payers, to make comparisons with other services, to provide consumer choice and to influence practice. The process of establishing evidence has evolved alongside the development of scientific principles, and the current gold standard of evidence for healthcare is the randomised controlled trial. There are questions regarding whether this method ...


Bone Tissue Material Properties Are Altered In Chronic Kidney Disease To Lower Fracture Resistance-Determining Bone Quality, Chelsea Marie Heveran 2017 University of Colorado at Boulder

Bone Tissue Material Properties Are Altered In Chronic Kidney Disease To Lower Fracture Resistance-Determining Bone Quality, Chelsea Marie Heveran

Mechanical Engineering Graduate Theses & Dissertations

Chronic kidney disease (CKD) is associated with a clinically-observed increase in bone fragility, yet the specific changes to fracture resistance-determining bone quality are not understood. CKD disrupts systemic mineral homeostasis and alters bone turnover. Thus, it was hypothesized that CKD deleteriously affects tissue-scale material properties. In Aim 1, mice with surgically-induced moderate CKD had diminished tissue-scale material properties, including mineral content and nanoindentation modulus, in bone formed during CKD compared with sham mice. Heterogeneity of microscale bone material was also altered with CKD. Next, CKD occurs most often in the elderly, yet geriatric patients with CKD have higher fracture risk ...


Diagnostic Utility Of Anti-Citrullinated Protein Antibody And Its Comparison With Rheumatoid Factor In Rheumatoid Arthritis, Aysha Habib Khan, Lena Jafri, M Ahraz Hussain, Saliha Ishaq 2016 Aga Khan University

Diagnostic Utility Of Anti-Citrullinated Protein Antibody And Its Comparison With Rheumatoid Factor In Rheumatoid Arthritis, Aysha Habib Khan, Lena Jafri, M Ahraz Hussain, Saliha Ishaq

Aysha Habib

Objective:

To assess the diagnostic utility of anti-citrullinated protein antibody (anti-CCP) in rheumatoid arthritis (RA) and compare it with rheumatoid factor (RF).

Study Design:

Analytical study.

Place and Duration of Study:

Section of Chemical Pathology, Department of Pathology and Microbiology and Medicine, the Aga Khan University, Karachi, from January to May 2010.

Methodology:

A review of medical records of patients presenting to the clinics with complaints of muscular or joint pains and who were tested for their serum anti-CCP was done. Inclusion criteria were presence of clinical synovitis in at least one joint and an absence of alternative diagnosis. Patients ...


2016 University Of New England College Of Osteopathic Medicine Fellowship Recipients, University of New England College of Osteopathic Medicine 2016 University of New England

2016 University Of New England College Of Osteopathic Medicine Fellowship Recipients, University Of New England College Of Osteopathic Medicine

Peter Morgane Research Fellowships

2016 recipients of the University of New England College of Osteopathic Medicine's Peter Morgane Research Fellowship.


Spinal Muscular Atrophy Treatment Via Targeting Smn2 Catalytic Core, Ravindra N. Singh, Natalia N. Singh 2016 Iowa State University

Spinal Muscular Atrophy Treatment Via Targeting Smn2 Catalytic Core, Ravindra N. Singh, Natalia N. Singh

Ravindra Singh

The present invention is directed to methods and compositions for blocking the effect of the intronic inhibitory splicing region of intron 7 of the SMN2 gene. The compositions and methods of the instant invention include short oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target sites in the SMN2 pre-mRNA, thereby modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript. The short target regions are 8-mers and 5-mers and also include the identification of a single nucleotide base that is essential for initiating a long distance stearic inhibitory interactions as well as novel targets distant from ...


Bone Marrow Transplantation For Feline Mucopolysaccharidosis I, Norman Matthew Ellinwood, Marie-Anne Colle, Margaret Weil, Margret Casal, Charles Vite, Staci Wiemelt, Christopher Hasson, Thomas O'Malley, Xingxuan He, Ulana Prociuk, Lucie Verot, John Melniczek, Anne Lannon, Gustavo Aguirre, Van Knox, Sydney Evans, Marie Vanier, Edward Schuchman, Steven Walkley, Mark Haskins 2016 University of Pennsylvania

Bone Marrow Transplantation For Feline Mucopolysaccharidosis I, Norman Matthew Ellinwood, Marie-Anne Colle, Margaret Weil, Margret Casal, Charles Vite, Staci Wiemelt, Christopher Hasson, Thomas O'Malley, Xingxuan He, Ulana Prociuk, Lucie Verot, John Melniczek, Anne Lannon, Gustavo Aguirre, Van Knox, Sydney Evans, Marie Vanier, Edward Schuchman, Steven Walkley, Mark Haskins

Gustavo D. Aguirre, VMD, PhD

Severe mucopolysaccharidosis type I (MPS I) is a fatal neuropathic lysosomal storage disorder with significant skeletal involvement. Treatment involves bone marrow transplantation (BMT), and although effective, is suboptimal, due to treatment sequelae and residual disease. Improved approaches will need to be tested in animal models and compared to BMT. Herein we report on bone marrow transplantation to treat feline mucopolysaccharidosis I (MPS I). Five MPS I stably engrafted kittens, transplanted with unfractionated bone marrow (6.3 × 107–1.1 × 109 nucleated bone marrow cells per kilogram) were monitored for 13–37 months post-engraftment. The tissue total glycosaminoglycan (GAG) content was ...


2016 Founders' Day, Philadelphia College of Osteopathic Medicine 2016 Philadelphia College of Osteopathic Medicine

2016 Founders' Day, Philadelphia College Of Osteopathic Medicine

Founders Day Programs

The 2016 Founders Day OJ Snyder Memorial Medal recipient was Richard Pascucci DO '75. The Philadelphia Campus Mason W. Pressly Memorial Medal Recipient was Zachary Herrman (DO '16). The Georgia campus Mason W. Pressly Memorial Medal Recipient was Jessica Mormando (DO '16).


Doctor Of Osteopathic Medicine Curriculum, Nova Southeastern University 2016 Nova Southeastern University

Doctor Of Osteopathic Medicine Curriculum, Nova Southeastern University

Health Professions Divisions Course Catalogs

No abstract provided.


Doctor Of Osteopathic Medicine Curriculum, Nova Southeastern University 2016 Nova Southeastern University

Doctor Of Osteopathic Medicine Curriculum, Nova Southeastern University

Health Professions Divisions Course Catalogs

No abstract provided.


College Of Osteopathic Medicine Overview, Nova Southeastern University 2016 Nova Southeastern University

College Of Osteopathic Medicine Overview, Nova Southeastern University

Health Professions Divisions Course Catalogs

No abstract provided.


Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 2015-2016), Philadelphia College of Osteopathic Medicine 2016 Philadelphia College of Osteopathic Medicine

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 2015-2016), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 2015/2016 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

  • Message from the President
  • PCOM Updates
  • Inauguration of the eighth President, Jay S. Feldstein, DO '81
  • Trained for Trauma Care: PCOM Alumni Were Well Prepared to Treat the Mass Casualties of May's Amtrak Derailment
  • Remembering Camille DiLullo, PhD, Professor of Anatomy
  • Class Notes
  • My Turn


Medical Interns', Residents' And Attending Physicians' Attitudes Towards Integrative Medicine And Recommended Treatments For Patients With Psoriasis, Jennifer L. Pacyon 2016 Philadelphia College of Osteopathic Medicine

Medical Interns', Residents' And Attending Physicians' Attitudes Towards Integrative Medicine And Recommended Treatments For Patients With Psoriasis, Jennifer L. Pacyon

PCOM Psychology Dissertations

Background: Psoriasis is a multifactorial disease that effect approximately 7.5 million Americans. There are a variety of traditional treatments for psoriasis (e.g. topical medications, biologics) that for many, are effective in combating the disease. However, traditional treatments often have aversive side effects and may not be appropriate for every patient (e.g. pregnant women). Additionally, the efficacy of these medications are variable leaving some looking for adjunctive treatment options. There is increasing evidence to support the use of adjunctive treatments for psoriatic patients (e.g. psychotherapy, mindfulness). However, research is variable in regards to medical professionals’ attitudes towards ...


Treatment Of Pasireotide Lar-Associated Hyperglycemia In A Patient With Acromegaly, Cheryl Rosenfeld 2016 Touro College of Osteopathic Medicine (Middletown)

Treatment Of Pasireotide Lar-Associated Hyperglycemia In A Patient With Acromegaly, Cheryl Rosenfeld

Touro College of Osteopathic Medicine (Middletown) Publications and Research

Objective: Hyperglycemia was noted in pasireotide long-acting release (PAS LAR}-treated patients with acromegaly during clinical trials. We describe a clinical approach to hyperglycemia in a patient with acromegaly and diabetes mellitus type 2 (DM2) during PAS LAR initiation and treatment.

Methods: Clinical response to PAS LAR, including self­ monitored blood glucose (SMBG) levels, HbA1c, IGF-1, and adverse effects, was reported. Case Presentation: A 44-year-old male was referred for consultation in 2007 owing to uncontrolled DM2 despite maximum metformin (MET) dose. Testing led to a biochemical diagnosis of acromegaly. An 8-mm pituitary adenoma was seen on MRI. Transsphenoidal pituitary adenoma ...


Few Geographic And Socioeconomic Variations Exist In Primary Total Shoulder Arthroplasty: A Multi-Level Study Of Australian Registry Data, Sharon L. Brennan-Olsen, Richard S. Page, Steven E. Lane, Michelle Lorimer, Rachelle Buchbinder, Richard H. Osborne, Julie A. Pasco, Anita E. Wluka, Kerrie M. Sanders, Peter R. Ebeling, Stephen E. Graves 2016 Australian Catholic University

Few Geographic And Socioeconomic Variations Exist In Primary Total Shoulder Arthroplasty: A Multi-Level Study Of Australian Registry Data, Sharon L. Brennan-Olsen, Richard S. Page, Steven E. Lane, Michelle Lorimer, Rachelle Buchbinder, Richard H. Osborne, Julie A. Pasco, Anita E. Wluka, Kerrie M. Sanders, Peter R. Ebeling, Stephen E. Graves

Faculty of Health Sciences Publications

Round: Associations between socioeconomic position ( SEP ) and the uptake of primary total shoulder arthroplasty ( TSA ) is not well understood in the Australian population, thus potentially limiting equitable allocation of healthcare resources. We used the Australian Orthopaedic Association National Joint Replacement Registry ( AOA NJRR ) to examine whether geographic or socioeconomic variations exist in TSA performed for a diagnosis of osteoarthritis 2007–11 for all Australians aged ≥40 years. Methods: Primary anatomical and reverse TSA data were extracted from the AOA NJRR which captures > 99 % of all TSA nationally. Residential addresses were cross-referenced to Australian Bureau of Statistics 2011 Census data to ...


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