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Facilitators And Barriers To Being Physically Active In A Rural Hawai’I Community: A Photovoice Perspective, Siosaia F. Hafoka, Sara J. Carr 2019 University of Hawaii at Manoa

Facilitators And Barriers To Being Physically Active In A Rural Hawai’I Community: A Photovoice Perspective, Siosaia F. Hafoka, Sara J. Carr

Asian / Pacific Island Nursing Journal

A large body of existing literature suggests associations between perceptions of the environment and physical activity status, but very few studies have examined perceptions among Native Hawaiian and Pacific Islander (NHPI) communities. The purpose of this study was to examine perceptions of the active living environment in Hawaiʻi in rural communities with a high proportion of NHPI. A total of thirteen adults were purposefully selected to participate in the study, and the Photovoice method was used to capture their perceptions. Three sessions were used to describe the purpose of the study, select and describe photographs, and identify emerging themes. A ...


Health-Assistive Smart Homes For Aging In Place: Leading The Way For Integration Of The Asian Immigrant Minority Voice, Connie Kim Yen Nguyen-Truong, Roschelle L. Fritz 2019 University of Hawai'i Manoa

Health-Assistive Smart Homes For Aging In Place: Leading The Way For Integration Of The Asian Immigrant Minority Voice, Connie Kim Yen Nguyen-Truong, Roschelle L. Fritz

Asian / Pacific Island Nursing Journal

Caring for America’s aging population is a complex humanitarian issue. The number of older adults is expected to increase to 98.5 million by 2060 with a 295% growth in foreign-born older adults, including Asian immigrants. Most older adults will have one or more chronic conditions and 95% of healthcare costs will be attributed to caring for these conditions. Among Asian Americans, common chronic conditions include respiratory disease, cancer, cardiovascular disease, and pain. The National Institutes of Health, Institute on Aging, and National Science Foundation call for innovative technologies to be developed by multidisciplinary teams to address these concerns ...


Introduction To Special Issue: Asian / Pacific Island Technology And Health, Reimund Serafica 2019 University of Nevada, Las Vegas

Introduction To Special Issue: Asian / Pacific Island Technology And Health, Reimund Serafica

Asian / Pacific Island Nursing Journal

Nurses are masters at multitasking—that is performing several nursing interventions simultaneously during a patient encounter. While the new technologies such as smart pumps, bar-code medication, administration systems, electronic health records (EHRs), wearables, and smartphones being introduced into our practice environments are designed to increases efficiency, promote safety, and streamline the work of nursing, we also need to see what is current and emerging in the research arena. We need to continue to seek new evidence-based practice to care effectively for the Asian/Pacific Islander populations and promote a healing environment while incorporating the advantages and efficiencies that technologies provide


Proceedings Of The 2018 Asian American/Pacific Islander Nurses Association Conference: Local To Global--Future Directions For Research On Health Disparities, Jillian Inouye 2018 University of Hawai'i at Manoa

Proceedings Of The 2018 Asian American/Pacific Islander Nurses Association Conference: Local To Global--Future Directions For Research On Health Disparities, Jillian Inouye

Asian / Pacific Island Nursing Journal

The Asian American / Pacific Islander Nurses Association’s 15th Annual International Conference was held September 22-23, 2018 at the Hilton Garden Inn, located in Southpoint, Durham, S.C. with 43 research presenters. The conference theme was Local to Global: Future Directions for Research on Health Disparities with a dozen internationally well-known leaders around the world as keynote and special session speakers. Drs. Hyeoneui Kim, PhD, MPH, RN; Duke University School of Nursing and Jeeyae Choi, PhD, RN; University of North Carolina Wilmington School of Nursing were co-chairs and led the conference topics which addressed the current trends and future directions ...


Development Of Onchocerca Volvulus In Humanized Nsg Mice And Detection Of Parasite Biomarkers In Urine And Serum., John B. Patton, Sasisekhar Bennuru, Mark L. Eberhard, Jessica A. Hess Ligas, April R. Torigian, Sara Lustigman, Thomas B. Nutman, David Abraham 2018 Thomas Jefferson University

Development Of Onchocerca Volvulus In Humanized Nsg Mice And Detection Of Parasite Biomarkers In Urine And Serum., John B. Patton, Sasisekhar Bennuru, Mark L. Eberhard, Jessica A. Hess Ligas, April R. Torigian, Sara Lustigman, Thomas B. Nutman, David Abraham

Department of Microbiology and Immunology Faculty Papers

BACKGROUND: The study of Onchocerca volvulus has been limited by its host range, with only humans and non-human primates shown to be susceptible to the full life cycle infection. Small animal models that support the development of adult parasites have not been identified.

METHODOLOGY/PRINCIPAL FINDINGS: We hypothesized that highly immunodeficient NSG mice would support the survival and maturation of O. volvulus and alteration of the host microenvironment through the addition of various human cells and tissues would further enhance the level of parasite maturation. NSG mice were humanized with: (1) umbilical cord derived CD34+ stem cells, (2) fetal derived ...


Pain, Depression, And Health-Related Quality Of Life Of Older Haenyeos (Women Divers), Eun Suk Ko, Kyung-Ja Kang 2018 JeJu Hamnaum Hospital, South Korea

Pain, Depression, And Health-Related Quality Of Life Of Older Haenyeos (Women Divers), Eun Suk Ko, Kyung-Ja Kang

Asian / Pacific Island Nursing Journal

This study aimed to provide basic data in order to develop effective intervention plans to improve the health-related quality of life of older haenyeos (professional female free divers). The study’s participants consisted of older haenyeos (≥65 years old) from seven fishing villages on Jeju Island, Korea. Data were collected using a questionnaire-based survey method, and the responses of 149 participants were analyzed. The participants’ mean pain score was 2.43 out of 5 points and their mean score for health-related quality of life was 61.18 out of 100 points. Depression was the strongest factor influencing health-related quality of ...


The Effect Of Patient Safety Educational Program On Nurses' Patient Safety Culture And Patient Safety Indicators, Nasrin Hanifi, Zahra Yazdanshenas, Masoumeh Namadian, Nima Motamed 2018 Zanjan University of Medical Sciences

The Effect Of Patient Safety Educational Program On Nurses' Patient Safety Culture And Patient Safety Indicators, Nasrin Hanifi, Zahra Yazdanshenas, Masoumeh Namadian, Nima Motamed

Asian / Pacific Island Nursing Journal

The need to improve patient’s safety is to change the patient’s safety culture. This study was conducted to determine the effect of the patient safety education program on nurses’ patient safety culture and patient safety indicators.

This single-blind clinical trial was conducted in two cardiac medical wards that were randomly selected as research settings among the hospital teaching wards of the Zanjan city in Zanjan. Twenty-six nurses participated in this study under in the experimental and control groups. The experimental group received the educational program for two sessions, and the control group received a booklet about patient safety ...


Lived Experience Of Health Seeking And Healthcare Utilization Among Korean Immigrant Women Living In Suburban Communities, Jin Young Seo, Wooksoo Kim, Sharon Hewner, Suzanne Dickerson 2018 SUNY, Buffalo, New York

Lived Experience Of Health Seeking And Healthcare Utilization Among Korean Immigrant Women Living In Suburban Communities, Jin Young Seo, Wooksoo Kim, Sharon Hewner, Suzanne Dickerson

Asian / Pacific Island Nursing Journal

Despite the rapid increase in Korean immigrant women in the United States, research on healthcare utilization and health-seeking behavior among Korean immigrant women is limited. The present study was designed to understand the health-seeking behavior and healthcare utilization of premenopausal Korean immigrant women living in suburban communities in the United States. The study was designed and guided by interpretive hermeneutic phenomenology. Twenty participants were recruited from suburban communities in Western New York. Individual, semistructured interviews were conducted and analyzed using a team approach. Korean immigrants experienced difficulties using the US healthcare system and significant differences between the US and Korean ...


Atherosclerosis In Subjects Newly Diagnosed With Human Immunodeficiency Virus Infection., Tatiana V Kirichenko, Veronika A Myasoedova, Tatiana E Shimonova, Alexandra A Melnichenko, Dmitri Sviridov, Igor A Sobenin, Alexey I Mazus, Alexander N Orekhov, Michael I Bukrinsky 2018 George Washington University

Atherosclerosis In Subjects Newly Diagnosed With Human Immunodeficiency Virus Infection., Tatiana V Kirichenko, Veronika A Myasoedova, Tatiana E Shimonova, Alexandra A Melnichenko, Dmitri Sviridov, Igor A Sobenin, Alexey I Mazus, Alexander N Orekhov, Michael I Bukrinsky

Microbiology, Immunology, and Tropical Medicine Faculty Publications

HIV infection is associated with the increased risk of cardiovascular disease (CVD), even in patients successfully treated with the combination antiretroviral therapy (cART). However, the relationship between HIV, cART, and pathogenesis of CVD remains controversial. In the present study, we evaluated the carotid intima-media thickness (CIMT), a surrogate marker of atherosclerosis, in HIV-infected subjects receiving or not receiving cART. One hundred nine newly diagnosed HIV-infected subjects and one hundred nine uninfected age-matched controls (all males) without the history of CVD, hypertension, or diabetes were recruited into the present study. Cross-sectional analysis at baseline (BL) showed significantly increased levels of triglycerides ...


West Meets East: A Westerner’S Reflections On Leadership, Marion Broome 2018 University of Hawai'i Manoa

West Meets East: A Westerner’S Reflections On Leadership, Marion Broome

Asian / Pacific Island Nursing Journal

This article describes the leadership journey of a nursing leader from the United States. Background information on the culture of the United States where the author was raised and educated is provided as is a discussion about how her leadership skills were influenced by American culture. She reflects on the similarities and differences in leadership journeys between the nurse leaders from five Asian countries who participated in the Women’s Leadership Workshop held at Duke University in 2017. The article concludes with suggestions for women in leadership, particularly nurses, across the globe.


Women’S Leadership And Nursing Profession In South Korea, Eui Geum Oh 2018 University of Hawai'i Manoa

Women’S Leadership And Nursing Profession In South Korea, Eui Geum Oh

Asian / Pacific Island Nursing Journal

The purpose of this article is to introduce women’s leadership in the nursing profession of South Korea. For this purpose, the article will briefly discuss the cultural background of Korean society at the beginning and explain how the values of the traditional society have influenced women’s leadership in the nursing profession in South Korea. Finally, I will discuss my personal experience of leadership development based on Bolman and Deal’s leadership typology, Reframing Organizations: Artistry, Choice and Leadership (2013).


Leadership In Nursing In Korea, Myungsun Yi 2018 University of Hawai'i Manoa

Leadership In Nursing In Korea, Myungsun Yi

Asian / Pacific Island Nursing Journal

Nurses are the largest workforce that impacts the health of the people. As the life expectancy and the number of people with chronic diseases increases in Asia, it is important for Asian nursing professionals to play a pivotal role in improving health status and quality of life by demonstrating their leadership. This article focuses on nursing leadership in Korea. Leadership exemplars were described in detail to show how successful nursing leaders set goals and challenged to meet these goals, despite numerous obstacles that exist in male-oriented society of Korea. And three essential elements that future nurse leaders should consider were ...


Features Of Women’S Leadership And Nursing In Japanese Culture, Reiko Sakashita 2018 University of Hawai'i Manoa

Features Of Women’S Leadership And Nursing In Japanese Culture, Reiko Sakashita

Asian / Pacific Island Nursing Journal

Mutual respect and harmonious relationships between people can be viewed as the fundamental spirit of Japanese culture. Japanese leaders try to keep the peace in human relations, rather than to achieve a goal. They become leaders due to internal and external conditions, rather than their own abilities. Japanese society has been basically male-dominated though the ratio of women leaders has increased recently. Higher education and development of academic societies in nursing have been very successful during the last two decades and nursing is one of the most trusted professions in Japan. However, some Japanese people still think a nurse is ...


Japanese American Nursing Education Leadership, Jillian Inouye PhD, Patricia T. Alpert 2018 University of Hawaii at Manoa

Japanese American Nursing Education Leadership, Jillian Inouye Phd, Patricia T. Alpert

Asian / Pacific Island Nursing Journal

Why are there so few Japanese-American Nursing Education leaders in the United States when Asians in general are considered the “model minority”? Several reasons point to the cultural and value differences of an Eastern versus Western perspective. Many who have addressed this issue in other professional fields explain this phenomenon as the bamboo ceiling. This article provides the experiences of two Japanese American Nurse Leaders framed through a theoretical framework proposed by Bolman and Deal (1991), which seems to relate to their “human resource leadership” style and the strong belief and empowerment of others. These leadership types develop symbols and ...


Tgf-Β Sustains Tumor Progression Through Biochemical And Mechanical Signal Transduction., Robert L Furler, Douglas F Nixon, Christine A Brantner, Anastas Popratiloff, Christel H Uittenbogaart 2018 George Washington University

Tgf-Β Sustains Tumor Progression Through Biochemical And Mechanical Signal Transduction., Robert L Furler, Douglas F Nixon, Christine A Brantner, Anastas Popratiloff, Christel H Uittenbogaart

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Transforming growth factor β (TGF-β) signaling transduces immunosuppressive biochemical and mechanical signals in the tumor microenvironment. In addition to canonical SMAD transcription factor signaling, TGF-β can promote tumor growth and survival by inhibiting proinflammatory signaling and extracellular matrix (ECM) remodeling. In this article, we review how TGF-β activated kinase 1 (TAK1) activation lies at the intersection of proinflammatory signaling by immune receptors and anti-inflammatory signaling by TGF-β receptors. Additionally, we discuss the role of TGF-β in the mechanobiology of cancer. Understanding how TGF-β dampens proinflammatory responses and induces pro-survival mechanical signals throughout cancer development is critical for designing therapeutics that ...


In Vivo And In Vitro Studies Of Cry5b And Nicotinic Acetylcholine Receptor Agonist Anthelmintics Reveal A Powerful And Unique Combination Therapy Against Intestinal Nematode Parasites, Yan Hu, Melanie Miller, Bo Zhang, Thanh-thanh Nguyen, Martin K. Nielsen, Raffi V. Aroian 2018 University of Massachusetts Medical School

In Vivo And In Vitro Studies Of Cry5b And Nicotinic Acetylcholine Receptor Agonist Anthelmintics Reveal A Powerful And Unique Combination Therapy Against Intestinal Nematode Parasites, Yan Hu, Melanie Miller, Bo Zhang, Thanh-Thanh Nguyen, Martin K. Nielsen, Raffi V. Aroian

Open Access Articles

BACKGROUND: The soil-transmitted nematodes (STNs) or helminths (hookworms, whipworms, large roundworms) infect the intestines of ~1.5 billion of the poorest peoples and are leading causes of morbidity worldwide. Only one class of anthelmintic or anti-nematode drugs, the benzimidazoles, is currently used in mass drug administrations, which is a dangerous situation. New anti-nematode drugs are urgently needed. Bacillus thuringiensis crystal protein Cry5B is a powerful, promising new candidate. Drug combinations, when properly made, are ideal for treating infectious diseases. Although there are some clinical trials using drug combinations against STNs, little quantitative and systemic work has been performed to define ...


Samhd1 Phosphorylation Coordinates The Anti-Hiv-1 Response By Diverse Interferons And Tyrosine Kinase Inhibition., Matthew A Szaniawski, Adam M Spivak, James E Cox, Jonathan L Catrow, Timothy Hanley, Elizabeth S C P Williams, Michel J Tremblay, Alberto Bosque, Vicente Planelles 2018 George Washington University

Samhd1 Phosphorylation Coordinates The Anti-Hiv-1 Response By Diverse Interferons And Tyrosine Kinase Inhibition., Matthew A Szaniawski, Adam M Spivak, James E Cox, Jonathan L Catrow, Timothy Hanley, Elizabeth S C P Williams, Michel J Tremblay, Alberto Bosque, Vicente Planelles

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Macrophages are susceptible to human immunodeficiency virus type 1 (HIV-1) infection despite abundant expression of antiviral proteins. Perhaps the most important antiviral protein is the restriction factor sterile alpha motif domain and histidine/aspartic acid domain-containing protein 1 (SAMHD1). We investigated the role of SAMHD1 and its phospho-dependent regulation in the context of HIV-1 infection in primary human monocyte-derived macrophages and the ability of various interferons (IFNs) and pharmacologic agents to modulate SAMHD1. Here we show that stimulation by type I, type II, and to a lesser degree, type III interferons share activation of SAMHD1 via dephosphorylation at threonine-592 as ...


Allatostatin C Modulates Nociception And Immunity In Drosophila., Nathaniel D Bachtel, Gary A Hovsepian, Douglas F Nixon, Ioannis Eleftherianos 2018 George Washington University

Allatostatin C Modulates Nociception And Immunity In Drosophila., Nathaniel D Bachtel, Gary A Hovsepian, Douglas F Nixon, Ioannis Eleftherianos

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Bacterial induced inflammatory responses cause pain through direct activation of nociceptive neurons, and the ablation of these neurons leads to increased immune infiltration. In this study, we investigated nociceptive-immune interactions in Drosophila and the role these interactions play during pathogenic bacterial infection. After bacterial infection, we found robust upregulation of ligand-gated ion channels and allatostatin receptors involved in nociception, which potentially leads to hyperalgesia. We further found that Allatostatin-C Receptor 2 (AstC-R2) plays a crucial role in host survival during infection with the pathogenic bacterium Photorhabdus luminescens. Upon examination of immune signaling in AstC-R2 deficient mutants, we demonstrated that Allatostatin-C ...


Analysis Of The Immunological Biomarker Profile During Acute Zika Virus Infection Reveals The Overexpression Of Cxcl10, A Chemokine Linked To Neuronal Damage., Felipe Gomes Naveca, Gemilson Soares Pontes, Aileen Yu-Hen Chang, George Allan Villarouco da Silva, Valdinete Alves do Nascimento, Dana Cristina da Silva Monteiro, +several additional authors 2018 George Washington University

Analysis Of The Immunological Biomarker Profile During Acute Zika Virus Infection Reveals The Overexpression Of Cxcl10, A Chemokine Linked To Neuronal Damage., Felipe Gomes Naveca, Gemilson Soares Pontes, Aileen Yu-Hen Chang, George Allan Villarouco Da Silva, Valdinete Alves Do Nascimento, Dana Cristina Da Silva Monteiro, +Several Additional Authors

Medicine Faculty Publications

BACKGROUND: Infection with Zika virus (ZIKV) manifests in a broad spectrum of disease ranging from mild illness to severe neurological complications and little is known about Zika immunopathogenesis.

OBJECTIVES: To define the immunologic biomarkers that correlate with acute ZIKV infection.

METHODS: We characterized the levels of circulating cytokines, chemokines, and growth factors in 54 infected patients of both genders at five different time points after symptom onset using microbeads multiplex immunoassay; comparison to 100 age-matched controls was performed for statistical analysis and data mining.

FINDINGS: ZIKV-infected patients present a striking systemic inflammatory response with high levels of pro-inflammatory mediators. Despite ...


The Small Rna Complement Of Adult Schistosoma Haematobium., Andreas J Stroehlein, Neil D Young, Pasi K Korhonen, Ross S Hall, Aaron R Jex, Bonnie L Webster, David Rollinson, Paul J Brindley, Robin B Gasser 2018 George Washington University

The Small Rna Complement Of Adult Schistosoma Haematobium., Andreas J Stroehlein, Neil D Young, Pasi K Korhonen, Ross S Hall, Aaron R Jex, Bonnie L Webster, David Rollinson, Paul J Brindley, Robin B Gasser

Microbiology, Immunology, and Tropical Medicine Faculty Publications

BACKGROUND: Blood flukes of the genus Schistosoma cause schistosomiasis-a neglected tropical disease (NTD) that affects more than 200 million people worldwide. Studies of schistosome genomes have improved our understanding of the molecular biology of flatworms, but most of them have focused largely on protein-coding genes. Small non-coding RNAs (sncRNAs) have been explored in selected schistosome species and are suggested to play essential roles in the post-transcriptional regulation of genes, and in modulating flatworm-host interactions. However, genome-wide small RNA data are currently lacking for key schistosomes including Schistosoma haematobium-the causative agent of urogenital schistosomiasis of humans.

METHODOLOGY: MicroRNAs (miRNAs) and other ...


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