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Treatment Outcome Of Rhino-Orbital-Cerebral Mucormycosis Patients: A Retrospective Institutional Study, Nishant S. Saxsenaa, Amrita Srivastavaa, Madhu Yadav, S.K. Kanaujia, H.K. Gautama, Shalani Tripathia, Shaleem Khana, Tripti Agrwala 2023 Departments of ENT

Treatment Outcome Of Rhino-Orbital-Cerebral Mucormycosis Patients: A Retrospective Institutional Study, Nishant S. Saxsenaa, Amrita Srivastavaa, Madhu Yadav, S.K. Kanaujia, H.K. Gautama, Shalani Tripathia, Shaleem Khana, Tripti Agrwala

Pan Arab Journal of Rhinology

Introduction Rhino-orbital-cerebral mucormycosis is an acute fungal infection characterized by fungal hyphal invasion of blood vessels resulting in thrombosis and infarction of the nasal, paranasal sinus, orbital, and cerebral tissues. Patients and methods This was a retrospective study conducted on 80 patients with biopsy-proven mucormycosis. The study was carried out in the Mucormycosis Ward of a Tertiary Care Medical College and Hospital during a period of 6 months from May 2021 to October 2021. Results Among 80 patients, 50 (62.5%) were males and 37 (37.5. %) were females. Of the patients, 53.75% were in the age group of 51–70 years. …


Editorial, Reda Kamela, Ahmed El-Faroukb 2023 Pan Arab Rhinology Society

Editorial, Reda Kamela, Ahmed El-Faroukb

Pan Arab Journal of Rhinology

No abstract provided.


Chronic Qat Chewing Effects On Nasopharynx, Oropharynx, And Laryngopharynx, Ahmed Mahmoud El Batawi, Ahmad M. Eltelety, Mohamed Abd Elmottaleb Sabaa 2023 ENT Department – Cairo University – Egypt

Chronic Qat Chewing Effects On Nasopharynx, Oropharynx, And Laryngopharynx, Ahmed Mahmoud El Batawi, Ahmad M. Eltelety, Mohamed Abd Elmottaleb Sabaa

Pan Arab Journal of Rhinology

Background Qat (also known as Khat, Kat, Miraa) is a green plant Catha edulis planted mainly in East and South Africa, and The Arabian Peninsula. It is widely and traditionally consumed by people in some regions. It has general effects on different systems such as cardiovascular and nervous system. Local effects were mainly described in the oral cavity such as periodontitis and white keratotic lesions. Scarce studies proved its relationship with cancer development. To date, there is a literature gap in reporting other local manifestations. In this study, the authors discuss additional local manifestations noted with chronic qat chewing. Aim …


Outcomes Of Middle Turbinate-Septal Adhesion Technique And Trans-Septal Middle Turbinate Suture Technique To Prevent Middle Turbinate Lateralization: A Comparative Study, Muaid I. Aziz Baban, Hiwa A. Rawandizi, Hozan F. Ali, Sahar J. Hadi, Shkar N. Mohammed 2023 Unit of Otorhinolaryngology–Head & Neck Surgery, Department of Surgery, University of Sulaimani, College of Medicine, Sulaymaniyah Teaching Hospital, Sulaymaniyah, Kurdistan Region, Iraq

Outcomes Of Middle Turbinate-Septal Adhesion Technique And Trans-Septal Middle Turbinate Suture Technique To Prevent Middle Turbinate Lateralization: A Comparative Study, Muaid I. Aziz Baban, Hiwa A. Rawandizi, Hozan F. Ali, Sahar J. Hadi, Shkar N. Mohammed

Pan Arab Journal of Rhinology

Background Middle turbinate lateralization (MTL) is the most common undesirable sequela after functional endoscopic sinus surgery (FESS), which can result in recurrent sinusitis. Objectives To examine the efficacy and outcomes of different techniques to prevent failure of the primary surgery. Patients and methods Eighty patients who presented with chronic rhinosinusitis listed for FESS were enrolled in this study. Patients were divided randomly into two groups, with 40 patients each. In group A, middle turbinate (MT) was stabilized by adhesion technique, and in group B, MT was stabilized via suture technique. A comparison of the effectiveness and the outcomes of both …


Topical Application Versus Intraturbinate Injection Of Botulinum Toxin Type A In The Treatment Of Noninfectious Chronic Rhinosinusitis, Naslshah G. Kazem, Mohamed A. Elsaid, Aya L. Hassan, Abdelrahman A. Abdelalim 2023 Department of Otorhinolaryngology, Faculty of Medicine, Benha University, Benha

Topical Application Versus Intraturbinate Injection Of Botulinum Toxin Type A In The Treatment Of Noninfectious Chronic Rhinosinusitis, Naslshah G. Kazem, Mohamed A. Elsaid, Aya L. Hassan, Abdelrahman A. Abdelalim

Pan Arab Journal of Rhinology

Background Chronic rhinosinusitis is a very common disorder caused by chronic inflammation or irritation of nasal mucosa. Objectives The purpose of this study was to evaluate the efficacy and safety of topical application of botulinum toxin type A (BTX-A) compared with intraturbinate injection for the treatment of noninfectious chronic rhinosinusitis. Patients and methods This prospective comparative study was carried out on 30 patients with noninfectious chronic rhinosinusitis. Patients were divided randomly into two groups. BTX-soaked merocel was applied topically in group A (topical group), which included 15 patients. Intraturbinate BTX injection was applied in group B (injected group), which included …


Review Of First 60 Pituitary Adenoma Cases Of A Skull Base Team, One Center Experience, Osama Hassan, Mohamed Fatthallah, Mohamed El Mallawany 2023 Lecturer of of Otorhinolaryngology – Head and Neck Surgery, Faculty of Medicine, Cairo University, Cairo, Egypt

Review Of First 60 Pituitary Adenoma Cases Of A Skull Base Team, One Center Experience, Osama Hassan, Mohamed Fatthallah, Mohamed El Mallawany

Pan Arab Journal of Rhinology

Background: Endoscopic endonasal transsphenoid approach of pituitary gland is being effectively replacing microscopic approach. This approach need a lot of training and stepwise learning to reach perfection. This study discuss the experience and pitfalls of an evolving skull base team in one institute. Aim of the work: Analysis of first sixty pituitary adenomas patients operated by an evolving skull base teams in one institute, and highlighting modifications introduced in their technique. Methodology: This is a retrospective analytical study of the medical records of first 60 pituitary adenoma patients who had presented to one center and had endoscopic trans-nasal trans-sphenoidal approach …


Anosmia And/Or Ageusia In Coronavirus Disease 2019-Infected Patients: Role Of Early Corticosteroids And Timeline, Naslshah G. Kazema, Emad R.H. Issakb 2023 Department of Otolaryngology, Faculty of Medicine, Benha University, Benha

Anosmia And/Or Ageusia In Coronavirus Disease 2019-Infected Patients: Role Of Early Corticosteroids And Timeline, Naslshah G. Kazema, Emad R.H. Issakb

Pan Arab Journal of Rhinology

Aim An increasing number of coronavirus disease 2019 (COVID-19) cases have started to experience unusual symptoms to the virus such as olfactory and gustatory dysfunctions. The study aimed to compare the effects of early corticosteroids (CS) administration versus no administration in the time-to-recovery from olfactory dysfunction in COVID-19. Patients and methods This comparative, nonrandomized study has been conducted at Benha University Hospital and another Primary Health Center in Cairo, Egypt, from January 2021 to June 2021. A total of 83 patients who have met the inclusion criteria were assigned into two groups: early-CS group (41 cases) and no-CS group (42 …


What Are We Missing In Adult Obstructive Sleep Apnea Clinical Evaluation? Review Of Official Guidelines, Eduardo J. Correa, Carlos O´Connor-Reina, Laura Rodriguez-Alcalá, Diego M. Conti, Alberto Rabino, Peter M. Baptista, Maria-Teresa Garcia-Iriarte, Guillermo Plaza 2023 Otorhinolaryngology Department Hospital Quironsalud Marbella. Spain

What Are We Missing In Adult Obstructive Sleep Apnea Clinical Evaluation? Review Of Official Guidelines, Eduardo J. Correa, Carlos O´Connor-Reina, Laura Rodriguez-Alcalá, Diego M. Conti, Alberto Rabino, Peter M. Baptista, Maria-Teresa Garcia-Iriarte, Guillermo Plaza

International Journal of Orofacial Myology and Myofunctional Therapy

Purpose: This article presents a narrative review of current recommendations for the clinical evaluation and management of adult patients with obstructive sleep apnea (OSA) to identify points missing from a myofunctional perspective.

Methods: The authors reviewed current official guidelines for adult patients with OSA, searching clinical evaluation and treatment recommendations for myofunctional therapy.

Results: None of the current guidelines for evaluation of adult OSA recommend performing a myofunctional evaluation. Only two guidelines consider myofunctional therapy (MFT) as a treatment modality for adult patients with OSA.

Conclusion: Despite the role of the pharyngeal dilator muscles as an …


Advances And Updates On Open-Access Publishing By The Ijom, Nancy Pearl Solomon 2022 IAOM

Advances And Updates On Open-Access Publishing By The Ijom, Nancy Pearl Solomon

International Journal of Orofacial Myology and Myofunctional Therapy

An online, open-access, no-fee model of the International Journal of Orofacial Myology and Myofunctional Therapy (IJOM) was established in December 2020 and includes all archived articles back to the journal’s origin in 1975. While aiming to increase content for the journal, the Editorial Review Board (ERB) has also been diligent about maintaining high standards for publication. This note From the Editor highlights recent publications, conference proceedings, and special issues. It also lists updates and challenges in terms of policies and practices. The IJOM remains both a traditional association-supported journal and is on the cutting edge of open-access publishing.


A National Multi-Institutional Analysis Of Predictors Of Surgical Site Complications And Unplanned Reoperation After Paramedian Forehead Flap Reconstruction, Garrett Ni, Rohan Brebion, Pablo A. Baltodano, Michael C. Coronado, Nicholas Elmer, Theresa K. Webster, Huaqing Zhao, Xiaoning Lu, Sthefano Araya, Sameer Patel 2022 Temple University

A National Multi-Institutional Analysis Of Predictors Of Surgical Site Complications And Unplanned Reoperation After Paramedian Forehead Flap Reconstruction, Garrett Ni, Rohan Brebion, Pablo A. Baltodano, Michael C. Coronado, Nicholas Elmer, Theresa K. Webster, Huaqing Zhao, Xiaoning Lu, Sthefano Araya, Sameer Patel

Student Papers & Posters

Background: Although postoperative complications of paramedian forehead flap (PMFF) are generally low, surgical site complications and unplanned reoperation can still occur. Recent literature suggests infection to be the most common complication following PMFF reconstruction. This study sought to determine the patient and preoperative factors associated with surgical site complications and unplanned reoperations at a national level.

Methods: Patients who underwent PMFF reconstruction from the ACS-NSQIP 2007 - 2019 database were analyzed to determine composite surgical site morbidity and unplanned return to the operating room. Patient and operative factors were also analyzed to assess independent risk factors for surgical site morbidity …


Tonsillectomy In Children With 22q11.2 Deletion Syndrome., Jill M. Arganbright, Paul Bryan Hankey, Meghan Tracy, Srivats Narayanan, Janelle R. Noel-Macdonnell PhD, David G. Ingram MD 2022 Children's Mercy Hospital

Tonsillectomy In Children With 22q11.2 Deletion Syndrome., Jill M. Arganbright, Paul Bryan Hankey, Meghan Tracy, Srivats Narayanan, Janelle R. Noel-Macdonnell Phd, David G. Ingram Md

Manuscripts, Articles, Book Chapters and Other Papers

Tonsillectomy is one of the most common procedures performed in children, however there are currently no published studies evaluating tonsillectomy in children with 22q11.2 deletion syndrome (22q11DS). With this study, our goal was to investigate the indications, efficacy, and complications of tonsillectomy in a pediatric cohort of patients with 22q11DS. This is a retrospective chart review of patients in our 22q Center's repository. Inclusion criteria were a diagnosis of 22q11DS and a history of tonsillectomy or adenotonsillectomy. Data collected included: indications for tonsillectomy, preoperative and postoperative polysomnography (PSG) results, and surgical complications. In total, 33 patients were included. Most common …


Proceedings Of The 2022 Iaom Convention, International Association of Orofacial Myology 2022 International Association of Orofacial Myology

Proceedings Of The 2022 Iaom Convention, International Association Of Orofacial Myology

International Journal of Orofacial Myology and Myofunctional Therapy

The International Association of Orofacial Myology (IAOM) held its 2022 Convention in Kansas City, Missouri from October 21 - 23. The Proceedings of the Convention contain abstracts and summaries of podium and poster presentations.


Endolymphatic Sac Tumor, Tanner P. Lyons, Laura Barry, Robert T Sataloff 2022 Philadelphia College of Osteopathic Medicine

Endolymphatic Sac Tumor, Tanner P. Lyons, Laura Barry, Robert T Sataloff

Otolaryngology (ENT) Resident Research

Masses occupying the retrolabyrinthine space are uncommon and most often represent paragangliomas, choroid plexus papilloma, endolymphatic sac tumors (ELSTs) or distant metastasis. ELSTs are rare, locally invasive tumors of the inner ear, with less than 300 cases reported in the literature. ELSTs are associated with von-Hippel Lindau (VHL) disease. Patients diagnosed with an ELST should undergo genetic testing for VHL disease, and individuals with confirmed VHL disease should be screened for ELST(s).


Metformin Increases Natural Killer Cell Functions In Head And Neck Squamous Cell Carcinoma Through Cxcl1 Inhibition, McKenzie Crist, Benyamin Yaniv, Sarah Palackdharry, Maria A. Lehn, Mario Medvedovic, Timothy Stone, Shuchi Gulati, Vidhya Karivedu, Michael Borchers, Bethany Fuhrman, Audrey Crago, Joseph Curry, Ubaldo Martinez-Outschoorn, Vinita Takiar, Trisha M. Wise-Draper 2022 University of Cincinnati

Metformin Increases Natural Killer Cell Functions In Head And Neck Squamous Cell Carcinoma Through Cxcl1 Inhibition, Mckenzie Crist, Benyamin Yaniv, Sarah Palackdharry, Maria A. Lehn, Mario Medvedovic, Timothy Stone, Shuchi Gulati, Vidhya Karivedu, Michael Borchers, Bethany Fuhrman, Audrey Crago, Joseph Curry, Ubaldo Martinez-Outschoorn, Vinita Takiar, Trisha M. Wise-Draper

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

BACKGROUND: Metformin slows tumor growth and progression in vitro, and in combination with chemoradiotherapy, resulted in high overall survival in patients with head and neck cancer squamous cell carcinoma (HNSCC) in our phase 1 clinical trial (NCT02325401). Metformin is also postulated to activate an antitumor immune response. Here, we investigate immunologic effects of metformin on natural killer (NK) and natural killer T cells, including results from two phase I open-label studies in patients with HNSCC treated with metformin (NCT02325401, NCT02083692).

METHODS: Peripheral blood was collected before and after metformin treatment or from newly diagnosed patients with HNSCC. Peripheral immune cell …


Nasal Surgery Versus Pharyngeal Surgery In The Treatment Of Obstructive Sleep Apnea, Ruxandra Oana Alius, Viorel Zainea, Catalina Voiosu, Irina Gabriela Ionita, Andreea Rusescu, Oana Denisa Balalau, Catalin Alius, Raluca Oana Pulpa, Razvan Hainarosie 2022 PROF. DR. DORIN HOCIOTĂ INSTITUTE OF PHONOAUDIOLOGY AND FUNCTIONAL ENT SURGERY, BUCHAREST, ROMANIA

Nasal Surgery Versus Pharyngeal Surgery In The Treatment Of Obstructive Sleep Apnea, Ruxandra Oana Alius, Viorel Zainea, Catalina Voiosu, Irina Gabriela Ionita, Andreea Rusescu, Oana Denisa Balalau, Catalin Alius, Raluca Oana Pulpa, Razvan Hainarosie

Journal of Mind and Medical Sciences

The endemic spread of obesity and unhealthy behaviors of modern society led to revisiting the real prevalence related to obstructive sleep apnea. Recent data support a paradigm shift towards individually tailored treatments which include functional surgery of the upper airways. This paper presents the results of a randomized interventional, prospective study on 68 patients referred by the general practitioner for obstructive sleep apnea. The eligible cohort consisted of 28 patients who were offered functional surgery for definitive relief of obstructive symptoms. After topographic diagnosis of the obstruction site and grading of the severity of the obstructive sleep apnea, the eligible …


Audio-Verbal Outcomes Following Cochlear Implantation In Ush1c Patients, Ty Theriot, Inga Kristaponyte, Moises Arriaga, Jennifer J. Lentz 2022 LSU Health Sciences Center- New Orleans

Audio-Verbal Outcomes Following Cochlear Implantation In Ush1c Patients, Ty Theriot, Inga Kristaponyte, Moises Arriaga, Jennifer J. Lentz

Medical Research Day

BACKGROUND: Usher syndrome (Usher) is the most common genetic cause of concurrent deafness and blindness. Currently, 3 clinical types and 10 genes are associated with the disease. Approximately 2.5% of Usher is caused by mutations in the USH1C gene. At least 50 mutations in the USH1C gene have been reported to cause USH1C, however the c.216G>A mutation accounts for nearly all Usher 1 cases in Acadian patients of Louisiana, USA, and Canada. Progress over the past two decades in access to genetic testing, early diagnosis, and cochlear implantation has significantly improved clinical management for patients with hearing loss, including …


Impact Of Adjuvant Radiation Therapy After Definitive Surgery In Senior Adults >80 Years Old With Advanced Head And Neck Squamous Cell Carcinoma On Overall Survival., Joann M Butkus, Meghan Crippen, Voichita Bar-Ad, Adam Luginbuhl 2022 Thomas Jefferson University

Impact Of Adjuvant Radiation Therapy After Definitive Surgery In Senior Adults >80 Years Old With Advanced Head And Neck Squamous Cell Carcinoma On Overall Survival., Joann M Butkus, Meghan Crippen, Voichita Bar-Ad, Adam Luginbuhl

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Background: Adjuvant radiotherapy (RT) following surgical resection confers a survival benefit for adult patients with locally advanced head and neck squamous cell carcinoma (HNSCC). We aim to investigate if adjuvant RT provides a similar survival advantage to patients ages 80+ through a national curated database.

Methods: This retrospective cohort study queried the National Cancer Database (NCDB) for all cases of HNSCC between 2004-2016. Patients treated with surgical resection alone were compared to those treated with surgery plus adjuvant RT. Overall survival (OS) was compared within adult (age <80 >years) and senior adult (age ≥80 years) cohorts using Kaplan-Meier analysis. Hazard ratios …


Oncocytic Papillary Cystadenoma Of The Larynx: A Rare And Masquerading Entity., Samuel Bosco, James Ding, Christopher Fundakowski 2022 Philadelphia College of Osteopathic Medicine

Oncocytic Papillary Cystadenoma Of The Larynx: A Rare And Masquerading Entity., Samuel Bosco, James Ding, Christopher Fundakowski

Otolaryngology (ENT) Resident Research

We cared for a 59-year-old female smoker who presented with a supraglottic lesion mimicking a laryngeal saccular cyst. The lesion was found to be a oncocytic papillary cystadenoma. This is a rare, benign neoplasm that accounts for 2–4.7% of minor salivary gland neoplasms. Oncocytic papillary cystadenoma of the larynx is even more rare, compromising less than 1% of all benign laryngeal neoplasms. This case highlights the importance of comprehensive differential diagnosis for cystic laryngeal lesions.


Proceedings Of The 2022 Icap Conference, International Consortium of Ankylofrenula Professionals 2022 International Association of Orofacial Myology

Proceedings Of The 2022 Icap Conference, International Consortium Of Ankylofrenula Professionals

International Journal of Orofacial Myology and Myofunctional Therapy

The International Consortium of Ankylofrenula Professional (ICAP) held its 2022 Conference in Vancouver, Canada from September 1 to 4, 2022, titled ‘Untangling Ankylofrenula: Collaborative Approaches to Best Practice Management’. The Conference Proceedings includes abstracts and summaries of plenary, concurrent, lightning and virtual presentations.


Libretto-531: A Phase Iii Study Of Selpercatinib In Multikinase Inhibitor-Naïve, Lori J Wirth, Marcia S Brose, Rossella Elisei, Jaume Capdevila, Ana O Hoff, Mimi I Hu, Makoto Tahara, Bruce Robinson, Ming Gao, Meng Xia, Patricia Maeda, Eric Sherman 2022 Massachusetts General Hospital

Libretto-531: A Phase Iii Study Of Selpercatinib In Multikinase Inhibitor-Naïve, Lori J Wirth, Marcia S Brose, Rossella Elisei, Jaume Capdevila, Ana O Hoff, Mimi I Hu, Makoto Tahara, Bruce Robinson, Ming Gao, Meng Xia, Patricia Maeda, Eric Sherman

Department of Medicine Faculty Papers

Selpercatinib is a first-in-class, highly selective and potent, central nervous system-active RET kinase inhibitor. In the phase I/II trial, selpercatinib demonstrated clinically meaningful antitumor activity with manageable toxicity in heavily pre-treated and treatment-naive patients with RET-mutant medullary thyroid cancer (MTC). LIBRETTO-531 (NCT04211337) is a multicenter, open-label, randomized, controlled, phase III trial comparing selpercatinib to cabozantinib or vandetanib in patients with advanced/metastatic RET-mutant MTC. The primary objective is to compare progression-free survival (per RECIST 1.1) by blinded independent central review of patients with progressive, advanced, multikinase inhibitor-naive, RET-mutant MTC treated with selpercatinib versus cabozantinib or vandetanib. …


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