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Frontal White Matter Integrity In Adults With Down Syndrome With And Without Dementia, David K. Powell, Allison Caban-Holt, Greg A. Jicha, William C. Robertson, Roberta Davis, Brian T. Gold, Frederick A. Schmitt, Elizabeth Head 2014 University of Kentucky

Frontal White Matter Integrity In Adults With Down Syndrome With And Without Dementia, David K. Powell, Allison Caban-Holt, Greg A. Jicha, William C. Robertson, Roberta Davis, Brian T. Gold, Frederick A. Schmitt, Elizabeth Head

Magnetic Resonance Imaging and Spectroscopy Center Faculty Publications

Adults with Down syndrome (DS) are at high risk for developing Alzheimer's disease after the age of 40 years. To detect white matter (WM) changes in the brain linked to dementia, fractional anisotropy (FA) from diffusion tensor imaging was used. We hypothesized that adults with DS without dementia (DS n = 10), DS with dementia (DSAD n = 10) and age matched non-DS subjects (CTL n = 10) would show differential levels of FA and an association with scores from the Brief Praxis Test and the Severe Impairment Battery. WM integrity differences in DS compared with CTL were found predominantly in the ...


Combination Therapy With Aerosol Il-2 And Nk Cells For The Treatment Of Osteosarcoma Lung Metastasis, Sergei R. Guma 2014 Texas Medical Center Library

Combination Therapy With Aerosol Il-2 And Nk Cells For The Treatment Of Osteosarcoma Lung Metastasis, Sergei R. Guma

UT GSBS Dissertations and Theses (Open Access)

The survival of patients with osteosarcoma lung metastases has not improved in the last 20 years. Novel alternative therapies are needed. The purpose of this investigation was to evaluate the efficacy of combining natural killer [NK] cell therapy with aerosol interleukin-2 [IL-2] for the treatment of osteosarcoma lung metastasis. The expression of NKG2D ligands was analyzed in five different human osteosarcoma cell lines and 103 patient samples (47 from primary tumors and 56 from lung metastases). We discovered that osteosarcoma expresses the ligands for the NKG2D. In vitro studies demonstrated that NK-mediated killing of osteosarcoma cells is dependent on the ...


Catastrophic Incident Search And Rescue Lessons From The 2013 Colorado Floods, Thomas Miner, Richard N. Bradley 2014 SelectedWorks

Catastrophic Incident Search And Rescue Lessons From The 2013 Colorado Floods, Thomas Miner, Richard N. Bradley

Richard N Bradley

The response to the Colorado floods is a textbook example of how to respond to catastrophic disasters Responders from hundreds of different organizations came together to form a single coordinated, unified command structure that resulted in the rapid and effective evacuation and rescue of hundreds of people in just three days. Local responders performed hundreds of highly dangerous rescues during the height of the storm. They established incident command at the county level using type 3 incident command teams. When they realized they were facing an unprecedented storm with catastrophic damage they asked for help and state and federal responders ...


Tip150 Potential Interaction With Glycogen Synthase Kinase (Gsk)-3-Beta To Facilitate Cell Migration, Maryam Chaudhry 2014 Georgia State University

Tip150 Potential Interaction With Glycogen Synthase Kinase (Gsk)-3-Beta To Facilitate Cell Migration, Maryam Chaudhry

Georgia State Undergraduate Research Conference

No abstract provided.


Potential Therapies For Cystic Fibrosis: A Look At Cystic Fibrosis Transmembrane Conductance Regulator Correctors And Potentiators, Spencer G. Jones 2014 McMaster University

Potential Therapies For Cystic Fibrosis: A Look At Cystic Fibrosis Transmembrane Conductance Regulator Correctors And Potentiators, Spencer G. Jones

The Meducator

Cystic Fibrosis (CF) is an autosomal recessive genetic disorder that is caused by a mutation of the anion channel termed the cystic fibrosis transmembrane conductance regulator (CFTR). Treatment for CF has improved over time; however, many therapies focus only on alleviating symptoms as they occur. There have been recent advances in therapies that repair mutant CFTR, including the administration of small molecules called CFTR modulators. CFTR modulators fall under two categories: correctors that prevent early degradation of CFTR and potentiators that increase conductance of existing CFTR. This review discusses the advantages of repairing mutant CFTR, some recent advances in treatment ...


Conceived In Liberty: Acknowledging The Human Rights Of The Unborn Through Opposing Gendercide, Nathan Gamble, Joel Gamble 2014 McMaster University

Conceived In Liberty: Acknowledging The Human Rights Of The Unborn Through Opposing Gendercide, Nathan Gamble, Joel Gamble

The Meducator

Sex-selective abortion, also colloquially referred to as “gendercide”, has become an increasingly prevalent issue. Technological advancements have allowed parents to know the sex of their child in utero. In some ethnic groups, parents frequently abort their unborn child (almost always female) if the sex does not align with cultural desires and pressure. 1 In India and China, the problem has become so endemic that physicians are barred from notifying parents of the sex of their baby in utero. This, however, has done little to curb the problem. 2


Compulsory Incentivized Organ Donation: A Case For A Fairer Organ Donor Policy In Ontario, Jasmine Gite, Niron Sukumar 2014 McMaster University

Compulsory Incentivized Organ Donation: A Case For A Fairer Organ Donor Policy In Ontario, Jasmine Gite, Niron Sukumar

The Meducator

Ontario, like many other countries around the world, follows a voluntary organ donor system. Citizens are given the option of becoming donors at the age of 16 and are scarcely reminded of the option ever after. As such, less than a quarter of Ontarians are registered organ donors. Not only is this an unnecessary waste of precious organs, it is also an extremely unfair system, as both donors and non-donors are considered of equal priority to receive organ transplants. We thus call for a compulsory incentivized organ donationsystem in Ontario, as a fairer and more efficient organ donor policy. This ...


Neuroimaging Of Unusual Glioblastoma Using Diffusion Tensor Imaging, Akshita Mehta, Lucien M. Levy, M. Isabel Almira-Suarez, Raymond Tu 2014 Himmelfarb Health Sciences Library, The George Washington University

Neuroimaging Of Unusual Glioblastoma Using Diffusion Tensor Imaging, Akshita Mehta, Lucien M. Levy, M. Isabel Almira-Suarez, Raymond Tu

GW Research Days 2014

Background: Gliosarcoma refers to an uncommon astrocytic tumor of the central nervous system. These tumors include both glial and mesenchymal components by definition, and are extremely malignant. Gliosarcomas are particular to tumors with distinct gliomatous and sarcomatous constituents, and are distinguished from gliobastomas which have undergone mesenchymal metaplasia. Gliosarcomas encompass 2-8% of all glioblastoma cases and tend to occupy the supratentorial regions of the brain, especially the temporal lobe. Rare infratentorial lesions including the cerebellar hemisphere, intraventricular, and multi-focal tumors have also been reported. Accurate neuroimaging diagnosis is critical and diffusion tensor imaging (DTI) and spectroscopy can be useful to ...


Improving Anatomical Knowledge Retention In Medical Students Entering The Surgery And Obstetrics And Gynecology Clinical Rotations By Nesting Interactive Modules, Samantha Ahle, Jill Krapf, Kirsten Marie Brown, Juliet Lee, Gisela Butera, Ellen Goldman, Myriam Ferzli, Rosalyn A. Jurjus 2014 Himmelfarb Health Sciences Library, The George Washington University

Improving Anatomical Knowledge Retention In Medical Students Entering The Surgery And Obstetrics And Gynecology Clinical Rotations By Nesting Interactive Modules, Samantha Ahle, Jill Krapf, Kirsten Marie Brown, Juliet Lee, Gisela Butera, Ellen Goldman, Myriam Ferzli, Rosalyn A. Jurjus

GW Research Days 2014

Background: It is well documented in the medical education literature that students retain minimal anatomy knowledge when transitioning from pre-clinical didactics to clinical application on the wards. In a previous study at our own institution we were able to quantify this knowledge deficit in students on surgical clerkships, specifically surgery and obstetrics and gynecology (OB/GYN). Using our previous data, we designed an integrated, nested clinical teaching model utilizing e-modules to review clinically relevant surgical anatomy during their clinical rotations.

Objective: The goal of this study is to evaluate the impact of a newly designed method of teaching clinically relevant ...


Establishing Normative Values For The Barnett Balance Assessment Tool: A Preliminary Study, Monica L. Cercone MSOTS, Katherine M. Grulke-Kidd MSOTS, Alora S. Haskin MSOTS, Kyle M. Medearis MSOTS, Clarissa J. Wegner MSOTS, Ellen Herlache-Pretzer Ed.D, MA, OTRL 2014 Western Michigan University

Establishing Normative Values For The Barnett Balance Assessment Tool: A Preliminary Study, Monica L. Cercone Msots, Katherine M. Grulke-Kidd Msots, Alora S. Haskin Msots, Kyle M. Medearis Msots, Clarissa J. Wegner Msots, Ellen Herlache-Pretzer Ed.D, Ma, Otrl

The Open Journal of Occupational Therapy

The purpose of this study was to establish normative data for the Barnett Balance Assessment (BBA) for individuals ages 18-70+ years. The BBA is a newly developed assessment tool that may address limitations present in other assessments currently used to detect balance deficits. The BBA was administered to 141 participants who had no history of medical issues that could impact balance. A review of the normative data collected indicated little variation in total assessment scores in the age categories of 18-29, 30-39, and 40-49, due to the presence of a ceiling effect. Variations existed in scores among participants in the ...


The Biology Of Dendritic Cell Subsets In Allergen-Induced Asthma, Benny Dua 2014 McMaster University

The Biology Of Dendritic Cell Subsets In Allergen-Induced Asthma, Benny Dua

Open Access Dissertations and Theses

Asthma is an inflammatory disorder of the airways, and there has been growing insight into the cellular and molecular mechanisms underlying the inflammatory basis of this disease. Research into the inflammatory mechanisms of asthma has progressively shifted focus from downstream effectors, such as mast cells and eosinophils, up to Th2 lymphocytes and their proallergic cytokines. Even more upstream in the allergic cascade are dendritic cells (DCs), potent APCs that orchestrate immune responses. Evidence supporting a role of DCs in regulating airway allergic inflammation is derived mainly from animal studies. In animal models of asthma, myeloid DCs (mDCs) induce and maintain ...


Prognosis In Current Heart Failure Patients, Ana C. Alba 2014 McMaster University

Prognosis In Current Heart Failure Patients, Ana C. Alba

Open Access Dissertations and Theses

Background: Heart failure (HF) constitutes an important growing medical and economic problem with high prevalence and mortality. Prognosis assessment remains a challenge because of the dynamic nature of HF and the existence of some unexplained variation in outcomes. Our objective was to refine the process of prognostic assessment in current HF patients.

Methods: We conducted a systematic review to identify existing risk prediction models in ambulatory HF patients, a meta-analysis to identify mortality predictors in HF patients treated with an implantable cardioverter defibrillator (ICD), a retrospective cohort study to validate a new model, the HF Meta-Score, derived from the results ...


Renal Function In Patients Undergoing Surgery, Michael Walsh 2014 McMaster University

Renal Function In Patients Undergoing Surgery, Michael Walsh

Open Access Dissertations and Theses

Reduced kidney function around the time of surgery is an important risk factor for postoperative mortality. Despite this there is limited information on how reduced kidney function prior to surgery alters prognosis, what causes sudden decrements in kidney function after surgery (known as acute kidney injury), or how they might be avoided. The studies in this thesis inform these knowledge gaps. Chapter 2 describes the results of a post hoc analysis of the interaction between preoperative estimated glomerular filtration rate, a marker of kidney function, and postoperative cardiac troponin T, a marker of heart damage, for predicting 30-day mortality in ...


Underutilization Of Statins And Aspirin Following Coronary Artery Bypass Graft Surgery, Kevin M. Curl, MD, Bryan Lebude, MD, Nicholas Ruggiero, MD, D L Fischman, MD, Andrew Rose, MD, Sulay Patel, MD, J. David Ogilby, MD, Paul Walinsky, MD, Babu Jasti, MD, Michael P. Savage, MD 2014 Thomas Jefferson University

Underutilization Of Statins And Aspirin Following Coronary Artery Bypass Graft Surgery, Kevin M. Curl, Md, Bryan Lebude, Md, Nicholas Ruggiero, Md, D L Fischman, Md, Andrew Rose, Md, Sulay Patel, Md, J. David Ogilby, Md, Paul Walinsky, Md, Babu Jasti, Md, Michael P. Savage, Md

Cardiology Faculty Papers

Introduction

Coronary artery bypass graft (CABG) surgery continues to be an important procedure for the treatment of coronary artery disease. However, clinically significant stenoses and complete bypass graft occlusion rates remain high, especially among saphenous vein grafts1. This is associated with significant morbidity and mortality. Both statin medications and aspirin have been shown in numerous clinical trials to play an important role in the medical management of coronary artery disease following CABG surgery. As per the ACC/AHA guidelines, both statin medications and aspirin have class I indications to support their use indefinitely following CABG, unless contraindication exists2. Long term ...


Bilateral Laparoscopic Partial Adrenalectomy: A Case Presentation And Review Of The Literature, Sean Satey, Nathan Richards, Frederick J. Brody 2014 Himmelfarb Health Sciences Library, The George Washington University

Bilateral Laparoscopic Partial Adrenalectomy: A Case Presentation And Review Of The Literature, Sean Satey, Nathan Richards, Frederick J. Brody

Surgery Faculty Publications

Laparoscopic adrenalectomy is the standard of care for benign adrenal diseases. Partial adrenalectomy has been performed for various tumors to preserve adrenal function while avoiding steroid supplements postoperatively. This article discusses a patient that underwent bilateral laparoscopic partial adrenalectomies for bilateral pheochromocytomas and reviews the literature on partial adrenalectomy. A 40-year-old woman with a recent diagnosis of hypertension and an emergent Caesarian section for pre-eclampsia presented to an outside clinic with labile blood pressure, diaphoresis, palpitations, and headache. Physical examination was unremarkable with no bruits appreciated in the neck or abdomen. Medical management of her hypertension was initiated with minimal ...


Gonadotropin-Releasing Hormone Agonist And Depot Medroxyprogesterone Acetate Following Uterine Artery Embolization In The Management Of Uterine Arteriovenous Malformation, Padma Krishnaswamy, Indushekar Subbanna, Gayatri Devi Sivasambu, Urvashi Thukral 2014 University of Iowa

Gonadotropin-Releasing Hormone Agonist And Depot Medroxyprogesterone Acetate Following Uterine Artery Embolization In The Management Of Uterine Arteriovenous Malformation, Padma Krishnaswamy, Indushekar Subbanna, Gayatri Devi Sivasambu, Urvashi Thukral

POG In Press

A young woman presenting with recurrent episodes of uterine bleeding due to an extensive uterine arteriovenous malformation was treated with two sessions of uterine artery embolization. Further bleeding was managed with a combination of gonadotropin-releasing hormone and depot medroxyprogesterone acetate. The patient remains asymptomatic with a significant decrease in uterine and pelvic vascularity at one year follow-up.

These drugs may decrease the need for repeat embolization.


Ultrasound-Enhanced Ocular Delivery Of Dexamethasone Sodium Phosphate: An In Vivo Study, Marjan Nabili, Aditi Shenoy, Shawn Chawla, Sankaranarayana P. Mahesh, Craig Geist, Vesna Zderic 2014 Himmelfarb Health Sciences Library, The George Washington University

Ultrasound-Enhanced Ocular Delivery Of Dexamethasone Sodium Phosphate: An In Vivo Study, Marjan Nabili, Aditi Shenoy, Shawn Chawla, Sankaranarayana P. Mahesh, Craig Geist, Vesna Zderic

Ophthalmology Faculty Publications

Background

The eye's unique anatomy and its physiological and anatomical barriers can limit effective drug delivery into the eye.

Methods

An in vivo study was designed to determine the effectiveness and safety of ultrasound application in enhancing drug delivery in a rabbit model. Permeability of a steroid ophthalmic drug, dexamethasone sodium phosphate, was investigated in ultrasound- and sham-treated cases. For this study, an eye cup filled with dexamethasone sodium phosphate was placed on the cornea. Ultrasound was applied at intensity of 0.8 W/cm2 and frequency of 400 or 600 kHz for 5 min. The drug concentration ...


Physiology And Advancements In Wound Healing, Adam Baker, MD 2014 Thomas Jefferson University

Physiology And Advancements In Wound Healing, Adam Baker, Md

Department of Otolaryngology - Head and Neck Surgery Faculty, Presentations and Grand Rounds

Outline of presentation:

Fundamentals

Advances

  • -Growth Factors
  • -Platelet Rich Plasma
  • -Engineered skin
  • -Hyperbaric Oxygen Therapy

Research


The Relationship Between Subnormal Peak-Stimulated Growth Hormone Levels And Auxological Characteristics In Obese Children, Jefferson Barrett, Louise S. Maranda, Benjamin U. Nwosu 2014 University of Massachusetts Medical School

The Relationship Between Subnormal Peak-Stimulated Growth Hormone Levels And Auxological Characteristics In Obese Children, Jefferson Barrett, Louise S. Maranda, Benjamin U. Nwosu

Endocrinology/Diabetes

Context: The hypothesis that obese children are overdiagnosed with growth hormone deficiency (GHD) has not been adequately investigated in the context of adiposity-related differences in auxology.

Aim: To investigate the differences in auxological parameters between short, prepubertal, obese children, and normal-weight peers who underwent growth hormone stimulation testing (GHST).

Hypothesis: Over-weight/obese children with GHD [peak growth hormone (GH) < 10 μg/L] will have higher values for growth velocity (GV) standard deviation score (SDS), bone age minus chronological age (BA − CA), and child height SDS minus mid-parental height (MPTH) SDS when compared to normal-weight GHD peers.

Subjects and Methods: A retrospective review of anthropometric and provocative GHST data of 67 prepubertal, GH-naïve children of age 10.21 ± 2.56 years (male n = 45, age 10.8 ± 2.60 years; female n = 22, age 8.94 ± 2.10 ...


Presbyacusis A Review, Balasubramanian Thiagarajan 2014 SelectedWorks

Presbyacusis A Review, Balasubramanian Thiagarajan

Balasubramanian Thiagarajan

Life expectancy of Humans is on the rise. World’s human population is aging rapidly. According to a report of US census Bureau nearly 24% of current world population is above the age of 50. This is a phenomenal number. Hearing loss due to degenerative process is rather common in old age. Presbyacusis is defined as a progressive bilateral symmetrical age related sensorineural hearing loss. The hearing loss is confined to higher frequencies. This causes a greater burden on them considering the fact that they already have failing eyesight. This article attempts to review the current scenario pertaining to Presbyacusis ...


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