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Pediatric Emergency Medical Care In Yerevan, Armenia: A Knowledge And Attitudes Survey Of Out-Of-Hospital Emergency Physicians., Aline A. Baghdassarian, Ross I. Donaldson, Andrew D Depiero, Nancy L Chernett, Harsh P. Sule MD 2014 Thomas Jefferson University

Pediatric Emergency Medical Care In Yerevan, Armenia: A Knowledge And Attitudes Survey Of Out-Of-Hospital Emergency Physicians., Aline A. Baghdassarian, Ross I. Donaldson, Andrew D Depiero, Nancy L Chernett, Harsh P. Sule Md

Department of Emergency Medicine Faculty Papers

BACKGROUND: Out-of-hospital emergency care is at an early stage of development in Armenia, with the current emergency medical services (EMS) system having emergency physicians (EPs) work on ambulances along with nurses. While efforts are underway by the Ministry of Health and other organizations to reform the EMS system, little data exists on the status of pediatric emergency care (PEC) in the country. We designed this study to evaluate the knowledge and attitudes of out-of-hospital emergency physicians in pediatric rapid assessment and resuscitation, and identify areas for PEC improvement.

METHODS: We distributed an anonymous, self-administered Knowledge and Attitudes survey to a ...


Wearable Technology In Obstetrical Emergency Simulation: A Pilot Study, Jami Goodwin, Rayan A. Elkattah, Martin Olsen 2014 East Tennessee State University

Wearable Technology In Obstetrical Emergency Simulation: A Pilot Study, Jami Goodwin, Rayan A. Elkattah, Martin Olsen

International Journal of Health Sciences Education

Background: Medical student involvement in clinical care of obstetrical emergencies is limited. Wearable technology, namely Google Glass, has been used to enhance the simulation experience for trainees at our institution. We present a pilot study that examines the utility of this technology in medical students’ education through remotely-conducted exercises in obstetric emergencies.

Materials & Methods: A total of thirteen medical students accepted the opportunity to participate in an obstetric emergencies training exercise with remote monitoring. Students wore the Google Glass device while participating in two simulated obstetrical emergencies: shoulder dystocia and vaginal breech delivery. A remote instructor monitored the students’ performance ...


Severe Ovarian Hyperstimulation Syndrome In Spontaneous Pregnancy Treated Successfully With Cabergoline, İsmail Temur,, Murat Bozkurt, Servet Gencdal, Yetkin Karasu, Duygu Kara Bozkurt, Hacer Pasaoğlu,, Kahraman Ülker, Suat Dede 2014 University of Iowa

Severe Ovarian Hyperstimulation Syndrome In Spontaneous Pregnancy Treated Successfully With Cabergoline, İsmail Temur,, Murat Bozkurt, Servet Gencdal, Yetkin Karasu, Duygu Kara Bozkurt, Hacer Pasaoğlu,, Kahraman Ülker, Suat Dede

POG In Press

Ovarian hyperstimulation syndrome (OHSS) is a relatively common complication in infertile patients treated with exogenous gonadotropins. Ovarian hyperstimulation in spontaneous pregnancies is a rare but possible. The pathogenesis of spontaneous OHSS is not well known. Risk factors for OHSS are young age, polycystic ovaries, low body mass index, high gonadotropin dose, increased estradiol and human chorionic gonadotropin levels, multiple pregnancy, OHSS history, molar pregnancy and hypothyroidism. In this report we present a case of severe spontaneous OHSS with a brief summary of the literature. She was hospitalized and treated in the clinic with the diagnosis of severe OHSS accompanying spontaneous ...


Opinions And Expectations Of Nursing Home Administrators, Jordan I. Kosberg 2014 Western Michigan University

Opinions And Expectations Of Nursing Home Administrators, Jordan I. Kosberg

The Journal of Sociology & Social Welfare

From a comparative analysis of 214 nursing homes in the Chicago area, it was found that the nursing home field is composed of institutions with great variations in treatment resources available to the residents (Kosberg and Tobin, 1972). While the determination of organizational correlates to the extent of treatment resources was the major objective of the study, an exploration of the attitudes of a sample of nursing home administrators was undertaken in an effort to learn of possible relationships between attitudes and the characteristics of facilities.

There is a commonly-held assumption that not only the academic background of an administrator ...


Neonatal Nmda Receptor Blockade Disrupts Spike Timing And Glutamatergic Synapses In Fast Spiking Interneurons In A Nmda Receptor Hypofunction Model Of Schizophrenia, Kevin S. Jones, Joshua G. Corbin, Molly M. Huntsman 2014 Himmelfarb Health Sciences Library, The George Washington University

Neonatal Nmda Receptor Blockade Disrupts Spike Timing And Glutamatergic Synapses In Fast Spiking Interneurons In A Nmda Receptor Hypofunction Model Of Schizophrenia, Kevin S. Jones, Joshua G. Corbin, Molly M. Huntsman

Pediatrics Faculty Publications

The dysfunction of parvalbumin-positive, fast-spiking interneurons (FSI) is considered a primary contributor to the pathophysiology of schizophrenia (SZ), but deficits in FSI physiology have not been explicitly characterized. We show for the first time, that a widely-employed model of schizophrenia minimizes first spike latency and increases GluN2B-mediated current in neocortical FSIs. The reduction in FSI first-spike latency coincides with reduced expression of the Kv1.1 potassium channel subunit which provides a biophysical explanation for the abnormal spiking behavior. Similarly, the increase in NMDA current coincides with enhanced expression of the GluN2B NMDA receptor subunit, specifically in FSIs. In this study ...


Efficacy Of Transoral Fundoplication For Treatment Of Chronic Gastroesophageal Reflux Disease Incompletely Controlled With High-Dose Proton-Pump Inhibitors Therapy: A Randomized, Multicenter, Open Label, Crossover Study., Karim S. Trad, Gilbert Simoni, William Edris Barnes, Ahmad Bassel Shughoury, Mamoon Raza, Jeffrey Alan Heise, Daniel Gilles Turgeon, Mark Alan Fox, Peter George Mavrelis 2014 Himmelfarb Health Sciences Library, The George Washington University

Efficacy Of Transoral Fundoplication For Treatment Of Chronic Gastroesophageal Reflux Disease Incompletely Controlled With High-Dose Proton-Pump Inhibitors Therapy: A Randomized, Multicenter, Open Label, Crossover Study., Karim S. Trad, Gilbert Simoni, William Edris Barnes, Ahmad Bassel Shughoury, Mamoon Raza, Jeffrey Alan Heise, Daniel Gilles Turgeon, Mark Alan Fox, Peter George Mavrelis

Surgery Faculty Publications

Background

The aim of this randomized, crossover study was to determine if transoral fundoplication (TF) could further improve clinical outcomes in partial responders to high-dose (HD) proton-pump inhibitor (PPI) therapy and to evaluate durability of TF.

Methods

In seven United States centers, patients with hiatal hernia ≤2 cm and abnormal esophageal acid exposure (EAE) were randomized to TF (n = 40) or HD PPIs (n = 23) group. At 6-month follow-up, PPI patients underwent crossover. We assessed clinical outcomes 6-month post TF in crossover patients (COP), as compared to 6-month of HD PPI therapy, and 12-month outcomes in patients initially randomized to ...


Tps Mutational Status Is A Potential Marker For Risk Stratification In Wilms Tumour With Diffuse Anaplasia, Mariana Maschietto, Richard D. Williams, Tasnim Chagtai, Sergey D. Popov, Neil J. Sebire, Gordan Vujanic, Elizabeth Perlman, James R. Anderson, Paul Grundy, Jeffrey S. Dome, Kathy Pritchard-Jones 2014 Himmelfarb Health Sciences Library, The George Washington University

Tps Mutational Status Is A Potential Marker For Risk Stratification In Wilms Tumour With Diffuse Anaplasia, Mariana Maschietto, Richard D. Williams, Tasnim Chagtai, Sergey D. Popov, Neil J. Sebire, Gordan Vujanic, Elizabeth Perlman, James R. Anderson, Paul Grundy, Jeffrey S. Dome, Kathy Pritchard-Jones

Pediatrics Faculty Publications

Purpose

The presence of diffuse anaplasia in Wilms tumours (DAWT) is associated with TP53 mutations and poor outcome. As patients receive intensified treatment, we sought to identify whetherTP53 mutational status confers additional prognostic information.

Patients and Methods

We studied 40 patients with DAWT with anaplasia in the tissue from which DNA was extracted and analysed for TP53 mutations and 17p loss. The majority of cases were profiled by copy number (n = 32) and gene expression (n = 36) arrays. TP53 mutational status was correlated with patient event-free and overall survival, genomic copy number instability and gene expression profiling.

Results

From ...


B-Type Natriuretic Peptide And C-Reactive Protein In The Prediction Of Atrial Fibrillation Risk: The Charge-Af Consortium Of Community-Based Cohort Studies, Moritz F. Sinner, Emelia J. Benjamin, Alvaro Alonso, David D. McManus 2014 University of Massachusetts Medical School

B-Type Natriuretic Peptide And C-Reactive Protein In The Prediction Of Atrial Fibrillation Risk: The Charge-Af Consortium Of Community-Based Cohort Studies, Moritz F. Sinner, Emelia J. Benjamin, Alvaro Alonso, David D. Mcmanus

Meyers Primary Care Institute Publications and Presentations

AIMS: B-type natriuretic peptide (BNP) and C-reactive protein (CRP) predict atrial fibrillation (AF) risk. However, their risk stratification abilities in the broad community remain uncertain. We sought to improve risk stratification for AF using biomarker information.

METHODS AND RESULTS: We ascertained AF incidence in 18 556 Whites and African Americans from the Atherosclerosis Risk in Communities Study (ARIC, n=10 675), Cardiovascular Health Study (CHS, n = 5043), and Framingham Heart Study (FHS, n = 2838), followed for 5 years (prediction horizon). We added BNP (ARIC/CHS: N-terminal pro-B-type natriuretic peptide; FHS: BNP), CRP, or both to a previously reported AF risk ...


Role Of Sirt1 In Vascular Complications Of Diabetes, Rokhsana Mortuza 2014 Western University

Role Of Sirt1 In Vascular Complications Of Diabetes, Rokhsana Mortuza

University of Western Ontario - Electronic Thesis and Dissertation Repository

Chronic diabetic complications are significant causes of morbidity. In diabetes, as the cellular changes are similar to aging, we investigated the role of sirtuins (SIRTs) in chronic diabetic complications.

We examined glucose and aging-induced changes in the endothelial cells (ECs), the primary targets of chronic diabetic complications. ECs in high glucose showed evidences of early senescence, being more pronounced in microvascular ECs in association with decreased SIRT1 and FOXO1-dependent reduction in antioxidant gene expressions. A regulatory relationship of deacetylator SIRT1 and histone acetylator p300 was identified. Renal and retinal tissues of diabetic animals showed similar results.

Having established such changes ...


Cavernous Hemangioma Uvula An Interesting Case Report And Review Of Literature, Balasubramanian Thiagarajan 2014 SelectedWorks

Cavernous Hemangioma Uvula An Interesting Case Report And Review Of Literature, Balasubramanian Thiagarajan

Balasubramanian Thiagarajan

Elongated uvula is mostly asymptomatic. In rare instances it may be come symptomatic. This article discusses a patient who presented with intractable cough due to cavernous hemangioma involving uvula. Uvula in this patient was found to be in contact with the posterior portion of the tongue. This case is being presented for its rarity.


Development Of A Fatal Noncompressible Truncal Hemorrhage Model With Combined Hepatic And Portal Venous Injury In Normothermic Normovolemic Swine, Ujwal R. Yanala, Jason M. Johanning, Iraklis I. Pipinos, Gustavo Larsen, William H. Velander, Mark A. Carlson 2014 University of Nebraska - Lincoln

Development Of A Fatal Noncompressible Truncal Hemorrhage Model With Combined Hepatic And Portal Venous Injury In Normothermic Normovolemic Swine, Ujwal R. Yanala, Jason M. Johanning, Iraklis I. Pipinos, Gustavo Larsen, William H. Velander, Mark A. Carlson

William H. Velander Publications

Noncompressible truncal hemorrhage and brain injury currently account for most early mortality of warfighters on the battlefield. There is no effective treatment for noncompressible truncal hemorrhage, other than rapid evacuation to a surgical facility. The availability of an effective field treatment for noncompressible truncal hemorrhage could increase the number of warfighters salvaged from this frequently-lethal scenario. Our intent was to develop a porcine model of noncompressible truncal hemorrhage with a ,50% one-hour mortality so that we could develop new treatments for this difficult problem. Normovolemic normothermic domestic swine (barrows, 3 months old, 34–36 kg) underwent one of three injury ...


Odontogenic Keratocyst Mandible An Interesting Case Report And Literature Review, Balasubramanian Thiagarajan, Geetha Ramamoorthy 2014 SelectedWorks

Odontogenic Keratocyst Mandible An Interesting Case Report And Literature Review, Balasubramanian Thiagarajan, Geetha Ramamoorthy

Balasubramanian Thiagarajan

The term odontogenic keratocyst was first described by Philipsen in 1956. This cyst actually arises from the cell rests of dental lamina. It can occur anywhere in the jaw but is commonly seen in the posterior part of the mandible. Since the clinical features and radiological appearance are not characteristic this condition is commonly misdiagnosed. This is more so when the lesion is related to the nonvital tooth. Odontogenic keratocyst has been rechristened as keratocystic odontogenic tumor by WHO working group in 2005. This was necessitated to differentiate this lesion from its orthokeratinizing variant which is currently considered as odontogenic ...


Subperiosteal Hematoma Of Orbit An Interesting Case Report And Review Of Literature, Balasubramanian Thiagarajan 2014 SelectedWorks

Subperiosteal Hematoma Of Orbit An Interesting Case Report And Review Of Literature, Balasubramanian Thiagarajan

Balasubramanian Thiagarajan

Subperiosteal Hematoma orbit is an uncommon disorder which may occur following injury to orbit. Of course there are other causes that cause this condition as well. This condition has been reported in young adults. This case report discusses a patient who developed subperiosteal hematoma following trivial injury to orbit. Since this condition had occurred following trivial injury to orbit diagnosis was not made pre operatively. It was discovered only on the table. A high index of suspicion and an accurate history is necessary to identify this condition. This case is being reported not only for its rarity but also to ...


Perampanel Inhibition Of Ampa Receptor Currents In Cultured Hippocampal Neurons, Chao-Yin Chen, Lucas Matt, Johannes Wilhelm Hell, Michael A. Rogawski 2014 SelectedWorks

Perampanel Inhibition Of Ampa Receptor Currents In Cultured Hippocampal Neurons, Chao-Yin Chen, Lucas Matt, Johannes Wilhelm Hell, Michael A. Rogawski

Michael A. Rogawski

Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized. Here the action of perampanel on AMPA receptors was investigated by whole-cell voltage-clamp recording in cultured rat hippocampal neurons. Perampanel caused a slow (τ~1 s at 3 µM), concentration-dependent inhibition of AMPA receptor currents evoked by AMPA and kainate. The rates of block and unblock of AMPA receptor currents were 1.5×105 M−1 s−1 and 0.58 s−1, respectively. Perampanel did ...


Introduction To Cancer Concepts: A Guidebook For The Non-Oncologist, Richard S. Pieters, Maryann Bishop-Jodoin, James Liebmann 2014 University of Massachusetts Medical School

Introduction To Cancer Concepts: A Guidebook For The Non-Oncologist, Richard S. Pieters, Maryann Bishop-Jodoin, James Liebmann

Cancer Concepts: A Guidebook for the Non-Oncologist

This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents an introduction to the Guidebook, which developed from the Cancer Concepts course at the University of Massachusetts Medical School.


Abnormal White Matter Integrity Related To Head Impact Exposure In A Season Of High School Varsity Football, Elizabeth M. Davenport, Christopher T. Whitlow, Jillian E. Urban, Mark A. Espeland, Jung Youngkyoo, Daryl A. Rosenbaum, Gerard A. Gioia, Alexander K. Powers, Joel D. Stitzel, Joseph A. Maldjian 2014 Himmelfarb Health Sciences Library, The George Washington University

Abnormal White Matter Integrity Related To Head Impact Exposure In A Season Of High School Varsity Football, Elizabeth M. Davenport, Christopher T. Whitlow, Jillian E. Urban, Mark A. Espeland, Jung Youngkyoo, Daryl A. Rosenbaum, Gerard A. Gioia, Alexander K. Powers, Joel D. Stitzel, Joseph A. Maldjian

Psychiatry and Behavioral Sciences Faculty Publications

The aim of this study was to determine whether the cumulative effects of head impacts from a season of high school football produce magnetic resonance imaging (MRI) measureable changes in the brain in the absence of clinically diagnosed concussion. Players from a local high school football team were instrumented with the Head Impact Telemetry System (HITS™) during all practices and games. All players received pre- and postseason MRI, including diffusion tensor imaging (DTI). Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) was also conducted. Total impacts and risk-weighted cumulative exposure (RWE), including linear (RWELinear), rotational (RWERotational), and combined components ...


Integrated Approach For Accurate Localization Of Optic Disc And Macula, Vaanathi Sundaresan, Keerthi Ram, Niranjan Joshi, Mohanasankar Sivaprakasam, Rashmin Gandhi 2014 University of Iowa

Integrated Approach For Accurate Localization Of Optic Disc And Macula, Vaanathi Sundaresan, Keerthi Ram, Niranjan Joshi, Mohanasankar Sivaprakasam, Rashmin Gandhi

Ophthalmic Medical Image Analysis

The location of three main anatomical structures in the retina namely the optic disc, the vascular arch, and the macula is significant for the analysis of retinal images. Presented here is a novel method that uses an integrated approach to automatically localize the optic disc and the macula with very high accuracy even in the presence of confounders such as lens artifacts, glare, bright pathologies and acquisition variations such as non-uniform illumination, blur and poor contrast. Evaluated on a collective set of 579 diverse pathological images from various publicly available datasets, our method achieves sensitivity > 99% and normalized localization error < 5% for optic disc and macula localization.


Computer-Aided Diagnosis System For The Assessment Of Retinal Vascular Changes, Behdad Dashtbozorg, Ana Maria Mendonca, Susana Penas, Aurelio Campilho 2014 University of Iowa

Computer-Aided Diagnosis System For The Assessment Of Retinal Vascular Changes, Behdad Dashtbozorg, Ana Maria Mendonca, Susana Penas, Aurelio Campilho

Ophthalmic Medical Image Analysis

This paper presents an automatic application that provides several retinal image analysis functionalities, namely vessel segmentation, vessel width estimation, artery/vein classification and optic disc segmentation. A pipeline of these methods allows the computation of important vessel related indexes, namely the Central Retinal Arteriolar Equivalent (CRAE), Central Retinal Venular Equivalent (CRVE) and Arteriolar-to-Venular Ratio (AVR), as well as various geometrical features associated with vessel bifurcations. The results for AVR estimation were assessed using the images of INSPIRE-AVR dataset; for this dataset, the mean error of the measured AVR values with respect to the reference was identical to the one achieved ...


Computer-Aided Diagnosis System For The Assessment Of Retinal Vascular Changes, Behdad Dashtbozorg, Ana Maria Mendonca, Susana Penas, Aurelio Campilho 2014 University of Iowa

Computer-Aided Diagnosis System For The Assessment Of Retinal Vascular Changes, Behdad Dashtbozorg, Ana Maria Mendonca, Susana Penas, Aurelio Campilho

Ophthalmic Medical Image Analysis

This paper presents an automatic application that provides several retinal image analysis functionalities, namely vessel segmentation, vessel width estimation, artery/vein classification and optic disc segmentation. A pipeline of these methods allows the computation of important vessel related indexes, namely the Central Retinal Arteriolar Equivalent (CRAE), Central Retinal Venular Equivalent (CRVE) and Arteriolar-to-Venular Ratio (AVR), as well as various geometrical features associated with vessel bifurcations. The results for AVR estimation were assessed using the images of INSPIRE-AVR dataset; for this dataset, the mean error of the measured AVR values with respect to the reference was identical to the one achieved ...


Achiko-D350: A Dataset For Early Amd Detection And Drusen Segmentation, Huiying Liu, Yanwu Xu, Damon W.K. Wong, Augustinus Laude, Tock Ham Lim, Jiang Liu 2014 University of Iowa

Achiko-D350: A Dataset For Early Amd Detection And Drusen Segmentation, Huiying Liu, Yanwu Xu, Damon W.K. Wong, Augustinus Laude, Tock Ham Lim, Jiang Liu

Ophthalmic Medical Image Analysis

Age related macular degeneration is the third leading cause of global blindness. Its prevalence is increasing in these years for the coming of ”aging population”. Early detection and grading can prevent it from becoming severe and protect vision. Drusen is an important indicator for AMD. Thus automatic drusen detection and segmentation has attracted much research attention in the past years. However, a barrier handicapping the research of drusen segmentation is the lack of a public dataset and test platform. To address this issue, in this paper, we publish a dataset, named ACHIKO-D350, with manually marked drusen boundary. ACHIKO-D350 includes 254 ...


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