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Pediatric Emergency Medical Care In Yerevan, Armenia: A Knowledge And Attitudes Survey Of Out-Of-Hospital Emergency Physicians., Aline A. Baghdassarian, Ross I. Donaldson, Andrew D Depiero, Nancy L Chernett, Harsh P. Sule MD 2014 Thomas Jefferson University

Pediatric Emergency Medical Care In Yerevan, Armenia: A Knowledge And Attitudes Survey Of Out-Of-Hospital Emergency Physicians., Aline A. Baghdassarian, Ross I. Donaldson, Andrew D Depiero, Nancy L Chernett, Harsh P. Sule Md

Department of Emergency Medicine Faculty Papers

BACKGROUND: Out-of-hospital emergency care is at an early stage of development in Armenia, with the current emergency medical services (EMS) system having emergency physicians (EPs) work on ambulances along with nurses. While efforts are underway by the Ministry of Health and other organizations to reform the EMS system, little data exists on the status of pediatric emergency care (PEC) in the country. We designed this study to evaluate the knowledge and attitudes of out-of-hospital emergency physicians in pediatric rapid assessment and resuscitation, and identify areas for PEC improvement.

METHODS: We distributed an anonymous, self-administered Knowledge and Attitudes survey to a ...


Fronto-Parietal And Cingulo-Opercular Network Integrity And Global Cognition In Health And Schizophrenia, Julia May Sheffield 2014 Washington University in St. Louis

Fronto-Parietal And Cingulo-Opercular Network Integrity And Global Cognition In Health And Schizophrenia, Julia May Sheffield

Arts & Sciences Electronic Theses and Dissertations

Growing evidence suggests that coordinated activity within specific functional brain networks supports cognitive ability, and that abnormalities in brain connectivity may underlie cognitive deficits observed in neuropsychiatric diseases, such as schizophrenia. Two functional networks, the fronto-parietal network (FPN) and cingulo-opercular network (CON), are hypothesized to support top-down control of executive functioning, and have therefore emerged as potential drivers of cognitive impairment in disease-states. Application of graph theory analysis to functional connectivity data provides characterizations of network topology, allowing for the analysis of relationships between cognitive ability and network integrity. In the current study we applied graph analysis to pseudo-resting state ...


Cavernous Hemangioma Uvula An Interesting Case Report And Review Of Literature, Balasubramanian Thiagarajan 2014 SelectedWorks

Cavernous Hemangioma Uvula An Interesting Case Report And Review Of Literature, Balasubramanian Thiagarajan

Balasubramanian Thiagarajan

Elongated uvula is mostly asymptomatic. In rare instances it may be come symptomatic. This article discusses a patient who presented with intractable cough due to cavernous hemangioma involving uvula. Uvula in this patient was found to be in contact with the posterior portion of the tongue. This case is being presented for its rarity.


Development Of A Fatal Noncompressible Truncal Hemorrhage Model With Combined Hepatic And Portal Venous Injury In Normothermic Normovolemic Swine, Ujwal R. Yanala, Jason M. Johanning, Iraklis I. Pipinos, Gustavo Larsen, William H. Velander, Mark A. Carlson 2014 University of Nebraska - Lincoln

Development Of A Fatal Noncompressible Truncal Hemorrhage Model With Combined Hepatic And Portal Venous Injury In Normothermic Normovolemic Swine, Ujwal R. Yanala, Jason M. Johanning, Iraklis I. Pipinos, Gustavo Larsen, William H. Velander, Mark A. Carlson

William H. Velander Publications

Noncompressible truncal hemorrhage and brain injury currently account for most early mortality of warfighters on the battlefield. There is no effective treatment for noncompressible truncal hemorrhage, other than rapid evacuation to a surgical facility. The availability of an effective field treatment for noncompressible truncal hemorrhage could increase the number of warfighters salvaged from this frequently-lethal scenario. Our intent was to develop a porcine model of noncompressible truncal hemorrhage with a ,50% one-hour mortality so that we could develop new treatments for this difficult problem. Normovolemic normothermic domestic swine (barrows, 3 months old, 34–36 kg) underwent one of three injury ...


Odontogenic Keratocyst Mandible An Interesting Case Report And Literature Review, Balasubramanian Thiagarajan, Geetha Ramamoorthy 2014 SelectedWorks

Odontogenic Keratocyst Mandible An Interesting Case Report And Literature Review, Balasubramanian Thiagarajan, Geetha Ramamoorthy

Balasubramanian Thiagarajan

The term odontogenic keratocyst was first described by Philipsen in 1956. This cyst actually arises from the cell rests of dental lamina. It can occur anywhere in the jaw but is commonly seen in the posterior part of the mandible. Since the clinical features and radiological appearance are not characteristic this condition is commonly misdiagnosed. This is more so when the lesion is related to the nonvital tooth. Odontogenic keratocyst has been rechristened as keratocystic odontogenic tumor by WHO working group in 2005. This was necessitated to differentiate this lesion from its orthokeratinizing variant which is currently considered as odontogenic ...


Subperiosteal Hematoma Of Orbit An Interesting Case Report And Review Of Literature, Balasubramanian Thiagarajan 2014 SelectedWorks

Subperiosteal Hematoma Of Orbit An Interesting Case Report And Review Of Literature, Balasubramanian Thiagarajan

Balasubramanian Thiagarajan

Subperiosteal Hematoma orbit is an uncommon disorder which may occur following injury to orbit. Of course there are other causes that cause this condition as well. This condition has been reported in young adults. This case report discusses a patient who developed subperiosteal hematoma following trivial injury to orbit. Since this condition had occurred following trivial injury to orbit diagnosis was not made pre operatively. It was discovered only on the table. A high index of suspicion and an accurate history is necessary to identify this condition. This case is being reported not only for its rarity but also to ...


Perampanel Inhibition Of Ampa Receptor Currents In Cultured Hippocampal Neurons, Chao-Yin Chen, Lucas Matt, Johannes Wilhelm Hell, Michael A. Rogawski 2014 SelectedWorks

Perampanel Inhibition Of Ampa Receptor Currents In Cultured Hippocampal Neurons, Chao-Yin Chen, Lucas Matt, Johannes Wilhelm Hell, Michael A. Rogawski

Michael A. Rogawski

Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized. Here the action of perampanel on AMPA receptors was investigated by whole-cell voltage-clamp recording in cultured rat hippocampal neurons. Perampanel caused a slow (τ~1 s at 3 µM), concentration-dependent inhibition of AMPA receptor currents evoked by AMPA and kainate. The rates of block and unblock of AMPA receptor currents were 1.5×105 M−1 s−1 and 0.58 s−1, respectively. Perampanel did ...


Introduction To Cancer Concepts: A Guidebook For The Non-Oncologist, Richard S. Pieters, Maryann Bishop-Jodoin, James Liebmann 2014 University of Massachusetts Medical School

Introduction To Cancer Concepts: A Guidebook For The Non-Oncologist, Richard S. Pieters, Maryann Bishop-Jodoin, James Liebmann

Cancer Concepts: A Guidebook for the Non-Oncologist

This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents an introduction to the Guidebook, which developed from the Cancer Concepts course at the University of Massachusetts Medical School.


Integrated Approach For Accurate Localization Of Optic Disc And Macula, Vaanathi Sundaresan, Keerthi Ram, Niranjan Joshi, Mohanasankar Sivaprakasam, Rashmin Gandhi 2014 University of Iowa

Integrated Approach For Accurate Localization Of Optic Disc And Macula, Vaanathi Sundaresan, Keerthi Ram, Niranjan Joshi, Mohanasankar Sivaprakasam, Rashmin Gandhi

Ophthalmic Medical Image Analysis

The location of three main anatomical structures in the retina namely the optic disc, the vascular arch, and the macula is significant for the analysis of retinal images. Presented here is a novel method that uses an integrated approach to automatically localize the optic disc and the macula with very high accuracy even in the presence of confounders such as lens artifacts, glare, bright pathologies and acquisition variations such as non-uniform illumination, blur and poor contrast. Evaluated on a collective set of 579 diverse pathological images from various publicly available datasets, our method achieves sensitivity > 99% and normalized localization error < 5% for optic disc and macula localization.


Computer-Aided Diagnosis System For The Assessment Of Retinal Vascular Changes, Behdad Dashtbozorg, Ana Maria Mendonca, Susana Penas, Aurelio Campilho 2014 University of Iowa

Computer-Aided Diagnosis System For The Assessment Of Retinal Vascular Changes, Behdad Dashtbozorg, Ana Maria Mendonca, Susana Penas, Aurelio Campilho

Ophthalmic Medical Image Analysis

This paper presents an automatic application that provides several retinal image analysis functionalities, namely vessel segmentation, vessel width estimation, artery/vein classification and optic disc segmentation. A pipeline of these methods allows the computation of important vessel related indexes, namely the Central Retinal Arteriolar Equivalent (CRAE), Central Retinal Venular Equivalent (CRVE) and Arteriolar-to-Venular Ratio (AVR), as well as various geometrical features associated with vessel bifurcations. The results for AVR estimation were assessed using the images of INSPIRE-AVR dataset; for this dataset, the mean error of the measured AVR values with respect to the reference was identical to the one achieved ...


Computer-Aided Diagnosis System For The Assessment Of Retinal Vascular Changes, Behdad Dashtbozorg, Ana Maria Mendonca, Susana Penas, Aurelio Campilho 2014 University of Iowa

Computer-Aided Diagnosis System For The Assessment Of Retinal Vascular Changes, Behdad Dashtbozorg, Ana Maria Mendonca, Susana Penas, Aurelio Campilho

Ophthalmic Medical Image Analysis

This paper presents an automatic application that provides several retinal image analysis functionalities, namely vessel segmentation, vessel width estimation, artery/vein classification and optic disc segmentation. A pipeline of these methods allows the computation of important vessel related indexes, namely the Central Retinal Arteriolar Equivalent (CRAE), Central Retinal Venular Equivalent (CRVE) and Arteriolar-to-Venular Ratio (AVR), as well as various geometrical features associated with vessel bifurcations. The results for AVR estimation were assessed using the images of INSPIRE-AVR dataset; for this dataset, the mean error of the measured AVR values with respect to the reference was identical to the one achieved ...


Achiko-D350: A Dataset For Early Amd Detection And Drusen Segmentation, Huiying Liu, Yanwu Xu, Damon W.K. Wong, Augustinus Laude, Tock Ham Lim, Jiang Liu 2014 University of Iowa

Achiko-D350: A Dataset For Early Amd Detection And Drusen Segmentation, Huiying Liu, Yanwu Xu, Damon W.K. Wong, Augustinus Laude, Tock Ham Lim, Jiang Liu

Ophthalmic Medical Image Analysis

Age related macular degeneration is the third leading cause of global blindness. Its prevalence is increasing in these years for the coming of ”aging population”. Early detection and grading can prevent it from becoming severe and protect vision. Drusen is an important indicator for AMD. Thus automatic drusen detection and segmentation has attracted much research attention in the past years. However, a barrier handicapping the research of drusen segmentation is the lack of a public dataset and test platform. To address this issue, in this paper, we publish a dataset, named ACHIKO-D350, with manually marked drusen boundary. ACHIKO-D350 includes 254 ...


Quantification Of The Retinal Vascular Network Structure: Towards Effective Monitoring Of Vessel Architecture Modulation In Diabetic Retinopathy, Delia Cabrera Debuc, William E. Smidy 2014 University of Iowa

Quantification Of The Retinal Vascular Network Structure: Towards Effective Monitoring Of Vessel Architecture Modulation In Diabetic Retinopathy, Delia Cabrera Debuc, William E. Smidy

Ophthalmic Medical Image Analysis

Diabetic retinopathy is the most common diabetic eye disease leading to vision loss. Disturbances have been detected in many aspects of ocular circulation in diabetes. However, hemodynamic and vessel architectural modulation have not been extensively investigated in DR. Therefore, an objective test for the early diagnosis, progression and therapeutic evaluation of DR based on vascular remodeling may aid to identify the individuals at great risk for vision threatening problems. In this paper, we present a methodology to characterize the microvascular network structure in diabetic individuals. Our preliminary results may pave the path towards effective monitoring of vessel architecture modulation in ...


Achiko-M Database For High Myopia Analysis And Its Evaluation, Fengshou Yin, Ruoying Li, Zhuo Zhang, Jun Cheng, Yanwu Xu, Damon Wee Kee Wong, Ngan Meng Tan, Ying Quan, Ai Ping Yow, Gopalakrishnan Kavitha, Guozhen Xu, Jiang Liu 2014 University of Iowa

Achiko-M Database For High Myopia Analysis And Its Evaluation, Fengshou Yin, Ruoying Li, Zhuo Zhang, Jun Cheng, Yanwu Xu, Damon Wee Kee Wong, Ngan Meng Tan, Ying Quan, Ai Ping Yow, Gopalakrishnan Kavitha, Guozhen Xu, Jiang Liu

Ophthalmic Medical Image Analysis

Myopia is the leading public health concern with high prevalence in developed countries. In this paper, we present the ACHIKO-M fundus image database with both myopic and emmetropic cases for high myopia study. The database contains 705 myopic subjects and 151 normal subjects with both left eye and right eye images for each subject. In addition, various clinical data is also available, allowing correlation study of different risk factors. We evaluated two state-of-the-art automated myopia detection algorithms on this database to show how it can be used. Both methods achieve more than 90% accuracy for myopia diagnosis. We will also ...


Tortuosity Classification Of Corneal Nerves Images Using A Multiple-Scale-Multiple-Window Approach, Roberto Annunziata, Ahmad Kheirkhah, Shruti Aggarwal, Bernardo M. Cavalcanti, Pedram Hamrah, Emanuele Trucco 2014 University of Iowa

Tortuosity Classification Of Corneal Nerves Images Using A Multiple-Scale-Multiple-Window Approach, Roberto Annunziata, Ahmad Kheirkhah, Shruti Aggarwal, Bernardo M. Cavalcanti, Pedram Hamrah, Emanuele Trucco

Ophthalmic Medical Image Analysis

Classify in vivo confocal microscopy corneal images by tortuosity is complicated by the presence of variable numbers of fibres of different tortuosity level. Instead of designing a function combining manually selected features into a single coefficient, as done in the literature, we propose a supervised approach which selects automatically the most relevant combination of shape features from a pre-defined dictionary. To our best knowledge, we are the first to consider features at different spatial scales and show experimentally their relevance in tortuosity modelling. Our results, obtained with a set of 100 images and 20 fold cross-validation, suggest that multinomial logistic ...


An Automated Framework Of Inner Segment/Outer Segment Defect Detection For Retinal Sd-Oct Images, Weifang Zhu, Fei Shi, Dehui Xiang, Enting Gao, Liyun Wang, Haoyun Chen, Xinjian Chen 2014 University of Iowa

An Automated Framework Of Inner Segment/Outer Segment Defect Detection For Retinal Sd-Oct Images, Weifang Zhu, Fei Shi, Dehui Xiang, Enting Gao, Liyun Wang, Haoyun Chen, Xinjian Chen

Ophthalmic Medical Image Analysis

The integrity of inner segment/outer segment (IS/OS) has high correlation with lower visual acuity in patients suffering from blunt trauma. An automated 3D IS/OS defect detection method based on the SD-OCT images was proposed. First, 11 surfaces were automatically segmented using the multiscale 3D graph-search approach. Second, the sub-volumes between surface 7 and 8 containing IS/OS region around the fovea (diameter of mm) were extracted and flattened based on the segmented retinal pigment epithelium layer. Third, 5 kinds of texture based features were extracted for each voxel. A KNN classifier was trained and each voxel was ...


Detection Of Retinal Hemorrhages In The Presence Of Blood Vessels, Garima Gupta, Keerthi Ram, S. Kulasekaran, Niranjan Joshi, Mohanasankar Sivaprakasam, Rashmin Gandhi 2014 University of Iowa

Detection Of Retinal Hemorrhages In The Presence Of Blood Vessels, Garima Gupta, Keerthi Ram, S. Kulasekaran, Niranjan Joshi, Mohanasankar Sivaprakasam, Rashmin Gandhi

Ophthalmic Medical Image Analysis

Segmentation of hemorrhages helps in improving the efficiency of computer assisted image analysis of diseases like diabetic retinopathy and hypertensive retinopathy. Hemorrhages are blood leakages lying in close proximity to blood vessels, which makes their delineation from blood vessels challenging. We use multiresolution morphological processing with a view of achieving perceptual grouping of the hemorrhagic candidates occurring in variable shapes, sizes and textures. We propose a novel method of suppression of candidates lying on blood vessels while attaining a good segmentation of true hemorrhages including the ones attached to the vessels. Evaluated on 191 images having different degrees of pathological ...


Comparison Of Image Registration Methods For Composing Spectral Retinal Images, Lauri Laaksonen, Ela Claridge, Pauli Falt, Markku Hauta-Kasari, Hannu Uusitalo, Lasse Lensu 2014 University of Iowa

Comparison Of Image Registration Methods For Composing Spectral Retinal Images, Lauri Laaksonen, Ela Claridge, Pauli Falt, Markku Hauta-Kasari, Hannu Uusitalo, Lasse Lensu

Ophthalmic Medical Image Analysis

Spectral retinal images have signficant potential for improving the early detection and visualization of subtle changes due to eye diseases and many systemic diseases. High resolution in both the spatial and the spectral domain can be achieved by capturing a set of narrowband channel images from which the spectral images are composed. With imaging techniques where the eye movement between the acquisition of the images is unavoidable, image registration is required. In this paper, the applicability of the state-of-the-art image registration methods for the composition of spectral retinal images is studied. The registration methods are quantitatively compared using synthetic channel ...


Multiple Ocular Diseases Detection By Graph Regularized Multi-Label Learning, Xiangyu Chen, Yanwu Xu, Lixin Duan, Zhuo Zhang, Damon Wing Kee Wong, Jiang Liu 2014 University of Iowa

Multiple Ocular Diseases Detection By Graph Regularized Multi-Label Learning, Xiangyu Chen, Yanwu Xu, Lixin Duan, Zhuo Zhang, Damon Wing Kee Wong, Jiang Liu

Ophthalmic Medical Image Analysis

We develop a general framework for multiple ocular diseases diagnosis, based on Graph Regularized Multi-label Learning (GRML). Glaucoma, Pathological Myopia (PM), and Age-related Macular Degeneration (AMD) are three leading ocular diseases in the world. By exploiting the correlations among these three diseases, a novel GRML scheme is investigated for a simultaneous detection of these three leading ocular diseases for a given fundus image. We validate our GRML framework by conducting extensive experiments on SiMES dataset. The results show area under curve (AUC) of the receiver operating characteristic curve in multiple ocular diseases detection are much better than traditional popular algorithms ...


Uncertainty Assessment Of Vessels Width Measurement From Intensity Profile Model Fitting In Fundus Images, Fantin Girard, Conrad Kavalec, Houssem Ben Tahar, Farida Cheriet 2014 University of Iowa

Uncertainty Assessment Of Vessels Width Measurement From Intensity Profile Model Fitting In Fundus Images, Fantin Girard, Conrad Kavalec, Houssem Ben Tahar, Farida Cheriet

Ophthalmic Medical Image Analysis

Arteriolar-to-venular diameter ratio (AVR) is an important clinical measurement that allows to characterize retinal vascular abnormalities. A reliable AVR measurement requires accurate and reproducible width measurement. However, in order to measure the vessel width automatically, an approximation of the intensity profile is required by fitting a model. The aim of the proposed study is to assess the uncertainties introduced in the vessel width measurements when choosing a specific distribution as an intensity profile model. Different models are described and an automatic vessel width measurement procedure is presented. The uncertainty introduced by each model is evaluated by computing the standard deviation ...


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