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Prostate Cancer: Patient Education For Changing Guidelines, Richard Mendez 2018 University of Vermont College of Medicine

Prostate Cancer: Patient Education For Changing Guidelines, Richard Mendez

Family Medicine Clerkship Student Projects

In May 2012 United States Preventative Services Task Force (USPSTF) recommended against prostate cancer screening, Grade D, with no other recommendation for providers. Since prostate cancer continues to be among the most common cancer in the United States among men, patients were exposed to previous guidelines during routine visits and require updated educational materials for primary care visits.


Intractable Epilepsy, Sameh Morkous MD 2017 Lehigh Valley Health Network

Intractable Epilepsy, Sameh Morkous Md

Department of Pediatrics

No abstract provided.


Diagnosis Of Lchad/Tfp Deficiency In An At Risk Newborn Using Umbilical Cord Blood Acylcarnitine Analysis, Donna Raval, Kristina Cusmano-Ozog, Omar Ayyub, Callie Jenevein, Laura Kofman, Brendan Lanpher, Natalie Hauser, Debra Regier 2017 George Washington University

Diagnosis Of Lchad/Tfp Deficiency In An At Risk Newborn Using Umbilical Cord Blood Acylcarnitine Analysis, Donna Raval, Kristina Cusmano-Ozog, Omar Ayyub, Callie Jenevein, Laura Kofman, Brendan Lanpher, Natalie Hauser, Debra Regier

Pathology Faculty Publications

Trifunctional protein deficiency/Long-chain hydroxyacyl-CoA dehydrogenase deficiency (LCHAD/TFP) deficiency is a disorder of fatty acid oxidation and ketogenesis. Severe neonatal lactic acidosis, cardiomyopathy, and hepatic dysfunction are caused by the accumulation of toxic long-chain acylcarnitines. The feasibility of umbilical cord blood use in screening for acylcarnitine analysis and free carnitine has been hypothesized but not reported in LCHAD/TFP neonates.

We present a 4 week old female who was at risk of inheriting LCHAD/TFP deficiency and was diagnosed at the time of delivery using umbilical cord blood. Umbilical cord blood was collected at delivery and sent for acylcarnitine ...


On Edge: The Impact Of Race-Related Vigilance On Obesity Status In African-Americans, Lauren R. Powell, William M. Jesdale, Stephenie C. Lemon 2017 University of Massachusetts Medical School

On Edge: The Impact Of Race-Related Vigilance On Obesity Status In African-Americans, Lauren R. Powell, William M. Jesdale, Stephenie C. Lemon

Stephenie C. Lemon

OBJECTIVE: Nearly half of African-Americans are classified as obese. Perceived racism has been associated with obesity, yet the internal experiences of racism have received little attention. African Americans who face racism may "ready themselves" to cope through survival strategies, including race-related vigilance. This study explores the association between race-related vigilance and obesity in African Americans. DESIGN AND METHODS: The Reactions to Race module of the Behavioral Risk Factor Surveillance Survey (years 2002-2010) was used. Our sample size consisted of 12,214 African-Americans. Race-related vigilance was assessed as: "How often do you think about your race?" and classified as: never, < daily, daily, and > daily ...


Evaluating Factors Affecting Clinicians’ Knowledge On Contrast Media: Kenyan Experience, Timothy Musila Mutala, Priscilla Nyambura Maina 2017 University of Nairobi

Evaluating Factors Affecting Clinicians’ Knowledge On Contrast Media: Kenyan Experience, Timothy Musila Mutala, Priscilla Nyambura Maina

The Journal of Global Radiology

Purpose: Our study aimed to establish exposure to and level of knowledge about contrast media among non-radiological clinicians and evaluate the contributory factors to the status.

Methods and Materials: A cross-sectional study was conducted between April and December 2015 through interviews using structured questionnaires. We recruited 197 non-radiological clinicians with experience in use of contrast media in their routine practice. They were of different cadres and years of experience, all working in a large referral hospital in Kenya. Levels of basic knowledge on contrast media were evaluated through a scoring system after each clinician responded to the questions provided. We ...


Follicular Dendritic Cell Sarcoma: A Rare Entity With Variable Pathologic Features And Prognosis, Sharif A. Ali MD, Miriam L. Enriquez MD, Shereen M. Gheith MD 2017 Lehigh Valley Health Network

Follicular Dendritic Cell Sarcoma: A Rare Entity With Variable Pathologic Features And Prognosis, Sharif A. Ali Md, Miriam L. Enriquez Md, Shereen M. Gheith Md

Shereen M.F. Gheith, M.D., PhD.

No abstract provided.


Peritoneal Lymphomatosis: The Failure Of Occam’S Razor, Ranjit R. Nair MD, Nicole M. Agostino DO, Shereen M F Gheith MD, Usman Shah MD 2017 Lehigh Valley Health Network

Peritoneal Lymphomatosis: The Failure Of Occam’S Razor, Ranjit R. Nair Md, Nicole M. Agostino Do, Shereen M F Gheith Md, Usman Shah Md

Shereen M.F. Gheith, M.D., PhD.

No abstract provided.


An Unusual Case Of Igg4 Associated Marginal Zone B-Cell Lymphoma Presenting As Subcutaneous Nodules Mimicking Lipomas, Ryan Mayo MD, Ranjit R. Nair MD, Shereen M F Gheith MD, PhD 2017 Lehigh Valley Health Network

An Unusual Case Of Igg4 Associated Marginal Zone B-Cell Lymphoma Presenting As Subcutaneous Nodules Mimicking Lipomas, Ryan Mayo Md, Ranjit R. Nair Md, Shereen M F Gheith Md, Phd

Shereen M.F. Gheith, M.D., PhD.

No abstract provided.


Dysfunctional Error-Related Processing In Incarcerated Youth With Elevated Psychopathic Traits, J. Michael Maurer, Vaughn R. Steele, Lora M. Cope, Gina M. Vincent, Julia M. Stephen, Vince D. Calhoun, Kent A. Kiehl 2017 University of New Mexico

Dysfunctional Error-Related Processing In Incarcerated Youth With Elevated Psychopathic Traits, J. Michael Maurer, Vaughn R. Steele, Lora M. Cope, Gina M. Vincent, Julia M. Stephen, Vince D. Calhoun, Kent A. Kiehl

Gina M. Vincent

Adult psychopathic offenders show an increased propensity towards violence, impulsivity, and recidivism. A subsample of youth with elevated psychopathic traits represent a particularly severe subgroup characterized by extreme behavioral problems and comparable neurocognitive deficits as their adult counterparts, including perseveration deficits. Here, we investigate response-locked event-related potential (ERP) components (the error-related negativity [ERN/Ne] related to early error-monitoring processing and the error-related positivity [Pe] involved in later error-related processing) in a sample of incarcerated juvenile male offenders (n=100) who performed a response inhibition Go/NoGo task. Psychopathic traits were assessed using the Hare Psychopathy Checklist: Youth Version (PCL:YV ...


Patient-Reported Outcome Measures In Arthroplasty Registries Report Of The Patient-Reported Outcome Measures Working Group Of The International Society Of Arthroplasty Registries Part Ii. Recommendations For Selection, Administration, And Analysis, Ola Rolfson, Eric Bohm, Patricia D. Franklin, Stephen Lyman, Geke Denissen, Jill Dawson, Jennifer Dunn, Kate Eresian Chenok, Michael Dunbar, Soren Overgaard, Goran Garellick, Anne Lubbeke 2017 University of Gothenburg

Patient-Reported Outcome Measures In Arthroplasty Registries Report Of The Patient-Reported Outcome Measures Working Group Of The International Society Of Arthroplasty Registries Part Ii. Recommendations For Selection, Administration, And Analysis, Ola Rolfson, Eric Bohm, Patricia D. Franklin, Stephen Lyman, Geke Denissen, Jill Dawson, Jennifer Dunn, Kate Eresian Chenok, Michael Dunbar, Soren Overgaard, Goran Garellick, Anne Lubbeke

Patricia D. Franklin

The International Society of Arthroplasty Registries (ISAR) Patient-Reported Outcome Measures (PROMs) Working Group have evaluated and recommended best practices in the selection, administration, and interpretation of PROMs for hip and knee arthroplasty registries. The 2 generic PROMs in common use are the Short Form health surveys (SF-36 or SF-12) and EuroQol 5-dimension (EQ-5D). The Working Group recommends that registries should choose specific PROMs that have been appropriately developed with good measurement properties for arthroplasty patients. The Working Group recommend the use of a 1-item pain question ("During the past 4 weeks, how would you describe the pain you usually have ...


Patient-Reported Outcome Measures In Arthroplasty Registries, Ola Rolfson, Kate Eresian Chenok, Eric Bohm, Anne Lubbeke, Geke Denissen, Jennifer Dunn, Stephen Lyman, Patricia D. Franklin, Michael Dunbar, Soren Overgaard, Goran Garellick, Jill Dawson 2017 University of Gothenburg

Patient-Reported Outcome Measures In Arthroplasty Registries, Ola Rolfson, Kate Eresian Chenok, Eric Bohm, Anne Lubbeke, Geke Denissen, Jennifer Dunn, Stephen Lyman, Patricia D. Franklin, Michael Dunbar, Soren Overgaard, Goran Garellick, Jill Dawson

Patricia D. Franklin

The International Society of Arthroplasty Registries (ISAR) Steering Committee established the Patient-Reported Outcome Measures (PROMs) Working Group to convene, evaluate, and advise on best practices in the selection, administration, and interpretation of PROMs and to support the adoption and use of PROMs for hip and knee arthroplasty in registries worldwide. The 2 main types of PROMs include generic (general health) PROMs, which provide a measure of general health for any health state, and specific PROMs, which focus on specific symptoms, diseases, organs, body regions, or body functions. The establishment of a PROM instrument requires the fulfillment of methodological standards and ...


What Outcomes Are Important For Gout Patients? In-Depth Qualitative Research Into The Gout Patient Experience To Determine Optimal Endpoints For Evaluating Therapeutic Interventions, Sophi Tatlock, Katja Rudell, Charlotte Panter, Rob Arbuckle, Leslie R. Harrold, William J. Taylor, Tara Symonds 2017 Adelphi Values

What Outcomes Are Important For Gout Patients? In-Depth Qualitative Research Into The Gout Patient Experience To Determine Optimal Endpoints For Evaluating Therapeutic Interventions, Sophi Tatlock, Katja Rudell, Charlotte Panter, Rob Arbuckle, Leslie R. Harrold, William J. Taylor, Tara Symonds

Leslie R. Harrold

BACKGROUND AND OBJECTIVES: Characterized by sudden onset of severe joint pain, swelling, redness, and tenderness to touch, gout 'flare ups' have a substantial impact on quality of life (QoL). This research employed a patient-centered approach to explore the symptoms and impacts of gout, and assess the content validity of existing patient-reported outcomes (PROs). METHODS: Qualitative interviews were conducted with 30 US gout patients (non-tophaceous: n = 20, tophaceous: n = 10) and five expert rheumatologists. Each interview included both concept elicitation (CE) questioning to learn about the patient experience and cognitive debriefing to assess the content validity of three PRO instruments (HAQ-DI ...


Elevated Prevalence Of Helicobacter Species And Virulence Factors In Opisthorchiasis And Associated Hepatobiliary Disease., Raksawan Deenonpoe, Eimorn Mairiang, Pisaln Mairiang, Chawalit Pairojkul, Yaovalux Chamgramol, Gabriel Rinaldi, Alex Loukas, Paul J. Brindley, Banchob Sripa 2017 George Washington University

Elevated Prevalence Of Helicobacter Species And Virulence Factors In Opisthorchiasis And Associated Hepatobiliary Disease., Raksawan Deenonpoe, Eimorn Mairiang, Pisaln Mairiang, Chawalit Pairojkul, Yaovalux Chamgramol, Gabriel Rinaldi, Alex Loukas, Paul J. Brindley, Banchob Sripa

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Recent reports suggest that Opisthorchis viverrini serves as a reservoir of Helicobacter and implicate Helicobacter in pathogenesis of opisthorchiasis-associated cholangiocarcinoma (CCA). Here, 553 age-sex matched cases and controls, 293 and 260 positive and negative for liver fluke O. viverrini eggs, of residents in Northeastern Thailand were investigated for associations among infection with liver fluke, Helicobacter and hepatobiliary fibrosis. The prevalence of H. pylori infection was higher in O. viverrini-infected than uninfected participants. H. pylori bacterial load correlated positively with intensity of O. viverrini infection, and participants with opisthorchiasis exhibited higher frequency of virulent cagA-positive H. pylori than those free of ...


Data From: Vitamin D Status In Pediatric Irritable Bowel Syndrome, Benjamin U. Nwosu, Louise S. Maranda, Ninfa Candela 2017 University of Massachusetts Medical School

Data From: Vitamin D Status In Pediatric Irritable Bowel Syndrome, Benjamin U. Nwosu, Louise S. Maranda, Ninfa Candela

Benjamin U. Nwosu

Manuscript abstract:

IMPORTANCE: Irritable bowel syndrome (IBS) is associated with significant morbidity in children and adolescents, and the therapeutic efficacy of available treatment options is limited. The role of vitamin D supplementation in pediatric IBS is unclear as the vitamin D status of pediatric patients with IBS is unknown. Equally, the relationship of vitamin D status with psychosomatic symptoms in children and adolescents is unclear.

AIM: To characterize the vitamin D status of pediatric patients with IBS using a case-control study design.

HYPOTHESIS: Serum 25-hydroxyvitamin D [25(OH)D] concentration will be similar between patients with IBS and controls.

SUBJECTS ...


A Mendelian Randomization Study Of The Effect Of Calcium On Coronary Artery Disease, Myocardial Infarction And Their Risk Factors, Lin Xu, Shi Lin Lin, C. Mary Schooling 2017 University of Hong Kong

A Mendelian Randomization Study Of The Effect Of Calcium On Coronary Artery Disease, Myocardial Infarction And Their Risk Factors, Lin Xu, Shi Lin Lin, C. Mary Schooling

Publications and Research

Meta-analyses of randomized controlled trials (RCTs) suggest calcium could have adverse effects on cardiovascular disease, although these findings are controversial. To clarify, we assessed whether people with genetically higher calcium had a higher risk of coronary artery disease (CAD), myocardial infarction (MI) and their risk factors. We used a two-sample Mendelian randomization study. We identified genetic variants (single nucleotide polymorphisms (SNPs)) that independently contributed to serum calcium at genome-wide significance which we applied to large extensively genotyped studies of CAD, MI, diabetes, lipids, glycaemic traits and adiposity to obtain unconfounded estimates, with body mass index (BMI) as a control outcome ...


Advances In Neglected Tropical Disease Vaccines: Developing Relative Potency And Functional Assays For The Na-Gst-1/Alhydrogel Hookworm Vaccine., Jill B. Brelsford, Jordan L Plieskatt, Anna Yakovleva, Amar Jariwala, Brian P Keegan, Jin Peng, Pengjun Xia, Guangzhao Li, Doreen Campbell, Maria Victoria Periago, Rodrigo Correa-Oliveira, Maria Elena Bottazzi, Peter J. Hotez, David Diemert, Jeffrey M. Bethony 2017 George Washington University

Advances In Neglected Tropical Disease Vaccines: Developing Relative Potency And Functional Assays For The Na-Gst-1/Alhydrogel Hookworm Vaccine., Jill B. Brelsford, Jordan L Plieskatt, Anna Yakovleva, Amar Jariwala, Brian P Keegan, Jin Peng, Pengjun Xia, Guangzhao Li, Doreen Campbell, Maria Victoria Periago, Rodrigo Correa-Oliveira, Maria Elena Bottazzi, Peter J. Hotez, David Diemert, Jeffrey M. Bethony

Microbiology, Immunology, and Tropical Medicine Faculty Publications

A new generation of vaccines for the neglected tropical diseases (NTDs) have now advanced into clinical development, with the Na-GST-1/Alhydrogel Hookworm Vaccine already being tested in Phase 1 studies in healthy adults. The current manuscript focuses on the often overlooked critical aspects of NTD vaccine product development, more specifically, vaccine stability testing programs. A key measure of vaccine stability testing is "relative potency" or the immunogenicity of the vaccine during storage. As with most NTD vaccines, the Na-GST-1/Alhydrogel Hookworm Vaccine was not developed by attenuation or inactivation of the pathogen (Necator americanus), so conventional methods for measuring relative ...


A Pilot Study To Assess The Feasibility, Safety And Acceptability Of Soy-Based Diet For Pregnant Women At High Risk For Gestational Diabetes Mellitus, Ling Shi, Vidya Iyer, Emily Jones, Tiffany A. Moore Simas, Alice H. Lichtenstein, Laura L. Hayman 2017 University of Massachusetts Boston

A Pilot Study To Assess The Feasibility, Safety And Acceptability Of Soy-Based Diet For Pregnant Women At High Risk For Gestational Diabetes Mellitus, Ling Shi, Vidya Iyer, Emily Jones, Tiffany A. Moore Simas, Alice H. Lichtenstein, Laura L. Hayman

Laura L. Hayman

Background: Diet plays an important role in the prevention and management of gestational diabetes mellitus (GDM). Previous studies suggest that soy protein and isoflavones may have beneficial effects on lipid and glucose metabolism. Little is known regarding the cardiometabolic effects of soy intake during pregnancy. This pilot study assessed the feasibility, safety and acceptability of daily consumption of soy foods during pregnancy in women at high risk for GDM, and participant adherence to their assigned treatment.

Methods: A randomized controlled trial (RCT) was conducted among pregnant women at high risk for GDM. The Soy group were counseled to consume a ...


A Comprehensive Audiometric Analysis Of Hearing Impairment And Tinnitus After Cisplatin-Based Chemotherapy In Survivors Of Adult-Onset Cancer, Heather E. Wheeler 2017 Loyola University Chicago

A Comprehensive Audiometric Analysis Of Hearing Impairment And Tinnitus After Cisplatin-Based Chemotherapy In Survivors Of Adult-Onset Cancer, Heather E. Wheeler

Bioinformatics Faculty Publications

Purpose: Cisplatin is widely used, but highly ototoxic. Effects of cumulative cisplatin dose on hearing loss have not been comprehensively evaluated in survivors of adult-onset cancer.

Patients and Methods: Comprehensive audiological measures were conducted on 488 North American male germ cell tumor (GCT) survivors in relation to cumulative cisplatin dose, including audiograms(0.25-12 kHz), tests of middle ear function, and tinnitus. American Speech-Language-Hearing Association (ASHA) criteria defined hearing loss severity. The geometric mean of hearing thresholds(0.25-12 kHz) summarized overall hearing status consistent with audiometric guidelines. Patients were sorted into quartiles of hearing thresholds of age- and sex-matched ...


Total Joint Replacement Prehabilitation: A Feasibility Study, Jennifer Baima, Elizabeth Z. Li, Amanda Doodlesack, Mathew J. Most, Jeffrey Metzmaker, David C. Ayers 2017 University of Massachusetts Medical School

Total Joint Replacement Prehabilitation: A Feasibility Study, Jennifer Baima, Elizabeth Z. Li, Amanda Doodlesack, Mathew J. Most, Jeffrey Metzmaker, David C. Ayers

Orthopedics and Physical Rehabilitation Publications and Presentations

Objectives: Pre-operative physical therapy has been shown to reduce post-acute care service utilization. Shifting rehabilitation to the presurgical period, referred to as prehabilitation, could result in reduced recovery time and cost. Limited access to physical therapy may prevent patients from achieving the benefits, and a standard set of independent exercises may be an alternative. We aim to assess the feasibility of an independent exercise program as a pre-surgical intervention for total hip and knee replacement.

Design: Participants were taught two exercises for hip or knee arthritis at least one week prior to surgery and instructed to perform them independently at ...


Two Cases Of Lyme Arthritis In Winter In New England: A Case Series, Jennifer Baima, Lauren Woo 2017 University of Massachusetts Medical School

Two Cases Of Lyme Arthritis In Winter In New England: A Case Series, Jennifer Baima, Lauren Woo

Orthopedics and Physical Rehabilitation Publications and Presentations

Case Diagnosis: Lyme Arthritis

Case Description: Patient 1 is a 26 year old male who presented in March with severe right knee pain and swelling for two weeks. He had a similar episode a month prior, but it resolved. The second episode progressed with pain from knee to foot and numbness on top of the foot. He had no known history of tick bites, travel, or trauma, but endorsed contact with a dog. On physical exam, he had a right knee effusion with limited ROM, diffuse joint line tenderness, positive McMurray’s, and pain with ligamentous testing. Synovial fluid of ...


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