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Rethinking Community Based Strategies To Tackle Health Inequities In South Asia, Zulfiqar Ahmed Bhutta, Abhay Bang, Kaosar Afsana, Bishal Gyawali, Mohammed Shafiq Mirzazada, Renuka Jayatissa 2019 The Aga Khan University

Rethinking Community Based Strategies To Tackle Health Inequities In South Asia, Zulfiqar Ahmed Bhutta, Abhay Bang, Kaosar Afsana, Bishal Gyawali, Mohammed Shafiq Mirzazada, Renuka Jayatissa

Department of Paediatrics and Child Health

No abstract provided.


Biomarkers In Patients With Mucopolysaccharidosis Type Ii And Iv., Honoka Fujitsuka, Kazuki Sawamoto, Hira Peracha, Robert W. Mason, William Mackenzie, Hironori Kobayashi, Seiji Yamaguchi, Yasuyuki Suzuki, Kenji Orii, Tadao Orii, Toshiyuki Fukao, Shunji Tomatsu 2019 Nemours/Alfred I. duPont Hospital for Children; Gifu University

Biomarkers In Patients With Mucopolysaccharidosis Type Ii And Iv., Honoka Fujitsuka, Kazuki Sawamoto, Hira Peracha, Robert W. Mason, William Mackenzie, Hironori Kobayashi, Seiji Yamaguchi, Yasuyuki Suzuki, Kenji Orii, Tadao Orii, Toshiyuki Fukao, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Glycosaminoglycans (GAGs), dermatan sulfate (DS), heparan sulfate (HS), and keratan sulfate (KS), are the primary biomarkers in patients with mucopolysaccharidoses (MPS); however, little is known about other biomarkers. To explore potential biomarkers and their correlation with GAGs, blood samples were collected from 46 MPS II patients, 34 MPS IVA patients, and 5 MPS IVB patients. We evaluated the levels of 8 pro-inflammatory factors (EGF, IL-1β, IL-6, MIP-1α, TNF-α, MMP-1, MMP-2, and MMP-9), collagen type II, and DS, HS (HS0S, HSNS), and KS (mono-sulfated, di-sulfated) in blood. Eight biomarkers measured were significantly elevated in untreated MPS II patients, compared with those ...


The Effects Of Alcohol On Plasma Lipid Mediators Of Inflammation Resolution In Patients With Type 2 Diabetes Mellitus, Anne Barden, Sujata Shinde, Michael Phillips, Lawrence Beilin, Emilie Mas, Jonathan M. Hodgson, Ian Puddey, Trevor A. Mori 2019 Edith Cowan University

The Effects Of Alcohol On Plasma Lipid Mediators Of Inflammation Resolution In Patients With Type 2 Diabetes Mellitus, Anne Barden, Sujata Shinde, Michael Phillips, Lawrence Beilin, Emilie Mas, Jonathan M. Hodgson, Ian Puddey, Trevor A. Mori

ECU Publications Post 2013

Background

Type 2 diabetes mellitus is characterized by peripheral insulin resistance and low-grade systemic inflammation. Inflammation resolution is recognised as an important process driven by specialised pro-resolving mediators of inflammation (SPMs) and has the potential to moderate chronic inflammation. Alcohol has the potential to affect synthesis of SPMs by altering key enzymes involved in SPM synthesis and may influence ongoing inflammation associated with Type 2 diabetes mellitus.

Aims

(i) To examine the effects of alcohol consumed as red wine on plasma SPM in men and women with Type 2 diabetes in a randomised controlled trial and (ii) compare baseline plasma ...


Resident Great Catches: Recognizing Resident Physicians, Susamita Kesh, Kristin Streiler 2019 Children's Mercy Hospital

Resident Great Catches: Recognizing Resident Physicians, Susamita Kesh, Kristin Streiler

Research Days

No abstract provided.


A Sensory-Based Program To Enhance Occupational Performance For Dementia, Ivy Annahi Torres-Flores, Jacob Gantan, Heather Anne August, Naomi Grace Wong 2019 Dominican University of California

A Sensory-Based Program To Enhance Occupational Performance For Dementia, Ivy Annahi Torres-Flores, Jacob Gantan, Heather Anne August, Naomi Grace Wong

Occupational Therapy | Graduate Capstone Projects

Dementia is a neurological disease, causing behavioral and cognitive symptoms, that progressively impairs an individual’s ability to engage in meaningful activities. Progressive deterioration associated with dementia impacts occupational performance and independence and quality of life. Sensory based interventions, such as drumming groups, have been hypothesized to be a non-pharmacological intervention for individuals with dementia. The purpose of this study was to analyze the effects of a sensory based intervention program, in this case participation in a drumming group, on functional engagement during self-feeding for individuals with dementia. Researchers gathered data over the course of two days using the Functional ...


Patient Willingness To Undergo Robotic Surgery: Identification And Validation Of A Predictive Model, Emily C. Anania 2019 Embry-Riddle Aeronautical University

Patient Willingness To Undergo Robotic Surgery: Identification And Validation Of A Predictive Model, Emily C. Anania

Dissertations and Theses

INTRODUCTION: The purpose of the current dissertation is to better understand the factors which make an individual willing (or unwilling) to undergo robotic surgery. Though surgical feasibility and provider perceptions are often studied, little research has investigated how patients perceive robotic surgical systems.

METHOD: A two-stage approach was taken in order to build and validate a regression equation in order to predict an individual’s willingness to undergo robotic surgery based on several factors. Stage 1 employed a sample size of 1324 participants in order to build the model. Participants responded to a survey indicating their willingness to undergo robotic ...


An Assessment Of Current Resources To Help Adolescents Quit Vaping, Karen Del'Olio, Nanette Vitali, Lori Pbert 2019 University of Massachusetts Medical School

An Assessment Of Current Resources To Help Adolescents Quit Vaping, Karen Del'olio, Nanette Vitali, Lori Pbert

Community Engagement and Research Symposia

Background: E-cigarette use, more commonly known as vaping to our youth, has been a growing epidemic with adolescents in the United States. The recent advisory from the U.S. Surgeon General emphasizes that we must act now to protect the health of our nation’s youth from a lifetime of nicotine addiction. According to a recent 2018 Center for Disease Control MMWR article , more than 3 million high school students (grades 9 – 12) and 570,000 middle school students (grades 6 – 8) in the United States are currently vaping; defined as ≥ 1 e-cigarette in the past 30 days. Researchers from ...


Decreasing Social Isolation In Adults Via A Cognitive Wellness Program, Lisa Yauch-Cadden, Kari Star, Paula Shiner 2019 Buzzards Bay Speech Therapy

Decreasing Social Isolation In Adults Via A Cognitive Wellness Program, Lisa Yauch-Cadden, Kari Star, Paula Shiner

Community Engagement and Research Symposia

In October 2015, Buzzards Bay Speech Therapy and Coastline Elderly Services, Inc, collaborated to address concerns regarding healthy aging in New Bedford. According to the 2014 Massachusetts Healthy Aging Data Report, New Bedford scored lowest in the state with regard to healthy aging, with 31 health indicators worse than the state average, including depression, mental illness, stroke and Alzheimer's disease. Recognizing that these indicators can lead to social isolation and further exacerbate health concerns, we developed a program focusing on cognitive wellness in order to enhance social engagement. The goal of the program is to provide evidenced based interventions ...


Building Sustainability In Times Of Uncertainty, Matthew Sadof 2019 University of Massachusetts Medical School-Baystate

Building Sustainability In Times Of Uncertainty, Matthew Sadof

Community Engagement and Research Symposia

Obama era grants were filled with the hopes of developing and implementing measures to improve healthcare delivery. Springfield Pediatrician Matt Sadof will present his experience as one of the Principal Investigators for the Massachusetts Alliance for Coordinated Care, a care coordination for children with medical complexity and social fragility funded by Center for Medicaid and Medicare Innovation at two urban centers in Massachusetts Baystate Children’s Hospital and Boston University Medical Center. As a consultative program it supported improved communication between primary care providers and specialists at two geographic locations across the state. Relying on an ambulatory ICU (complex care ...


An Assessment Of Current Resources To Help Adolescents Quit Vaping, Karen Del'Olio, Nanette Vitali, Lori Pbert 2019 University of Massachusetts Medical School

An Assessment Of Current Resources To Help Adolescents Quit Vaping, Karen Del'olio, Nanette Vitali, Lori Pbert

Lori Pbert

Background: E-cigarette use, more commonly known as vaping to our youth, has been a growing epidemic with adolescents in the United States. The recent advisory from the U.S. Surgeon General emphasizes that we must act now to protect the health of our nation’s youth from a lifetime of nicotine addiction. According to a recent 2018 Center for Disease Control MMWR article , more than 3 million high school students (grades 9 – 12) and 570,000 middle school students (grades 6 – 8) in the United States are currently vaping; defined as ≥ 1 e-cigarette in the past 30 days. Researchers from ...


Treating Postpartum Refractory Long Qt Syndrome With Cervical Ganglion Sympathectomy, Nikhil A. Mehta MBBS, Mario Caruso DO, Syed Rafay Ali Sabzwari MD, Lohit Garg MD, Jeffrey Gordon MD, Talha Nazir MD 2019 Lehigh Valley Health Network

Treating Postpartum Refractory Long Qt Syndrome With Cervical Ganglion Sympathectomy, Nikhil A. Mehta Mbbs, Mario Caruso Do, Syed Rafay Ali Sabzwari Md, Lohit Garg Md, Jeffrey Gordon Md, Talha Nazir Md

Department of Medicine

No abstract provided.


Sudden Cardiac Death Associated With Malignant Mitral Valve Prolapse, Damon Mcenroe MD, Fnu Vikram MD, Kailyn Mann DO, Lohit Garg MD, Syed Rafay Ali Sabzwari, Nael Hawwa MD 2019 Lehigh Valley Health Network

Sudden Cardiac Death Associated With Malignant Mitral Valve Prolapse, Damon Mcenroe Md, Fnu Vikram Md, Kailyn Mann Do, Lohit Garg Md, Syed Rafay Ali Sabzwari, Nael Hawwa Md

Department of Medicine

No abstract provided.


The Myth Of "It's All In Your Head", 2019 DePaul University

The Myth Of "It's All In Your Head"

DePaul Magazine

Researchers at DePaul's Center for Community Research are mapping the brain to uncover the causes of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Psychologist Leonard Jason has been carrying out community-based epidemiology prevalence studies that show that about one million Americans, many of them from ethnic minorities, are afflicted with the condition.


Empiric Antibiotic Use For Infectious Conjunctivitis Provides Little Clinical Benefit, Matthew M. Rolain 2019 Wayne State University School of Medicine

Empiric Antibiotic Use For Infectious Conjunctivitis Provides Little Clinical Benefit, Matthew M. Rolain

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Rose PW, Harnden A, Brueggemann AB, et al. Chloramphenicol treatment for acute infective conjunctivitis in children in primary care: a randomised double-blind placebo-controlled trial. Lancet. 2005;366(9479):37-43. doi: 10.1016/S0140-6736(05)66709-8.


Bisphosphonates Can Be Safely Given To Patients With Hypercalcemia And Renal Insufficiency Secondary To Multiple Myeloma, Matthew J. Miller 2019 Wayne State University School of Medicine

Bisphosphonates Can Be Safely Given To Patients With Hypercalcemia And Renal Insufficiency Secondary To Multiple Myeloma, Matthew J. Miller

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Itou K, Fukuyama T, Sasabuchi Y, et al. Safety and efficacy of oral rehydration therapy until 2 h before surgery: a multicenter randomized controlled trial. Journal of Anesthesia. 2012;26(1):20-27. doi: 10.1007/s00540-011-1261-x.


Guggulsterone Activates Adipocyte Beiging Through Direct Effects On 3t3-L1 Adipocytes And Indirect Effects Mediated Through Raw264.7 Macrophages., Colette N Miller, Janaiya S Samuels, Yusra Azhar, Ashish Parmar, Rangaiah Shashidharamurthy, Srujana Rayalam 2019 Philadelphia College of Osteopathic Medicine

Guggulsterone Activates Adipocyte Beiging Through Direct Effects On 3t3-L1 Adipocytes And Indirect Effects Mediated Through Raw264.7 Macrophages., Colette N Miller, Janaiya S Samuels, Yusra Azhar, Ashish Parmar, Rangaiah Shashidharamurthy, Srujana Rayalam

Rangaiah Shashidharamurthy

Background: Plant-derived phytochemicals have been of emerging interest as anti-obesity compounds due to their apparent effects on promoting reduced lipid accumulation in adipocytes. Despite such promising evidence, little is known about the potential mechanisms behind their anti-obesity effects. The aim of this study is to establish potential anti-obesity effects of the phytochemical guggulsterone (GS). Methods: Mature 3T3-L1 adipocytes were treated with GS, derived from the guggul plant native in northern India, to investigate its effects on mitochondrial biogenesis and adipocyte "beiging." Further, to explore the relationship between macrophages and adipocytes, 3T3-L1s were treated with conditioned media from GS-treated RAW264.7 ...


Astrocytes Infected With Chlamydia Pneumoniae Demonstrate Altered Expression And Activity Of Secretases Involved In The Generation Of Β-Amyloid Found In Alzheimer Disease, Zein Al-Atrache, Danielle B Lopez, Susan Hingley, Denah Appelt 2019 Philadelphia College of Osteopathic Medicine

Astrocytes Infected With Chlamydia Pneumoniae Demonstrate Altered Expression And Activity Of Secretases Involved In The Generation Of Β-Amyloid Found In Alzheimer Disease, Zein Al-Atrache, Danielle B Lopez, Susan Hingley, Denah Appelt

Denah Appelt

BACKGROUND: Epidemiologic studies strongly suggest that the pathophysiology of late-onset Alzheimer disease (AD) versus early-onset AD has environmental rather than genetic causes, thus revealing potentially novel therapeutic targets to limit disease progression. Several studies supporting the "pathogen hypothesis" of AD demonstrate a strong association between pathogens and the production of β-amyloid, the pathologic hallmark of AD. Although the mechanism of pathogen-induced neurodegeneration of AD remains unclear, astrocytes, a key player of the CNS innate immune response and producer/metabolizer of β-amyloid, have been implicated. We hypothesized that Chlamydia pneumoniae infection of human astrocytes alters the expression of the amyloid precursor ...


Perilymphatic Irx-2 Cytokine Therapy To Enhance Tumor Infiltrating Lymphocytes And Pd-L1 Expression Preceding Curative-Intent Therapy In Early Stage Breast Cancer, Joanna Pucilowska, Venkatesh Rajamanickam, Katherine Sanchez, Valerie Conrad, Alison Conlin, Shagheyegh Aliabadi-Wahle, Shu-Ching Chang, Gary Grunkemeier, Nikki Moxon, Staci Mellinger, Maritza Martel, James Egan, Monil Shah, David B Page 2019 Earle A. Chiles Research Institute, Portland, OR; Providence Cancer Institute, Portland, OR

Perilymphatic Irx-2 Cytokine Therapy To Enhance Tumor Infiltrating Lymphocytes And Pd-L1 Expression Preceding Curative-Intent Therapy In Early Stage Breast Cancer, Joanna Pucilowska, Venkatesh Rajamanickam, Katherine Sanchez, Valerie Conrad, Alison Conlin, Shagheyegh Aliabadi-Wahle, Shu-Ching Chang, Gary Grunkemeier, Nikki Moxon, Staci Mellinger, Maritza Martel, James Egan, Monil Shah, David B Page

Shu-Ching Chang, PhD, MS

Background: Cytokines are being explored as a therapeutic strategy to modulate the tumor microenvironment and facilitate immunotherapy benefit in breast cancer. Here, we investigate a locoregional therapeutic approach whereby cytokines (IRX-2) are administered into the subcutaneous peri-areolar tissue (in an anatomic distribution similar to sentinel lymph node mapping) to facilitate immune cell recruitment/activation within the draining lymph nodes and tumor in ESBC. IRX-2 is derived from ex vivo phytohemagglutinin-stimulated lymphocytes and contains multiple cytokines including IL-1β, IL-2, TNF-α, IFN-γ, IL-6, IL-8, and GM-CSF, with stable concentrations from lot to lot. Preclinically, IRX-2 activates T-cells and natural killer (NK) cells ...


Astrocytes Infected With Chlamydia Pneumoniae Demonstrate Altered Expression And Activity Of Secretases Involved In The Generation Of Β-Amyloid Found In Alzheimer Disease, Zein Al-Atrache, Danielle B Lopez, Susan Hingley, Denah Appelt 2019 Philadelphia College of Osteopathic Medicine

Astrocytes Infected With Chlamydia Pneumoniae Demonstrate Altered Expression And Activity Of Secretases Involved In The Generation Of Β-Amyloid Found In Alzheimer Disease, Zein Al-Atrache, Danielle B Lopez, Susan Hingley, Denah Appelt

Susan T. Hingley

BACKGROUND: Epidemiologic studies strongly suggest that the pathophysiology of late-onset Alzheimer disease (AD) versus early-onset AD has environmental rather than genetic causes, thus revealing potentially novel therapeutic targets to limit disease progression. Several studies supporting the "pathogen hypothesis" of AD demonstrate a strong association between pathogens and the production of β-amyloid, the pathologic hallmark of AD. Although the mechanism of pathogen-induced neurodegeneration of AD remains unclear, astrocytes, a key player of the CNS innate immune response and producer/metabolizer of β-amyloid, have been implicated. We hypothesized that Chlamydia pneumoniae infection of human astrocytes alters the expression of the amyloid precursor ...


Effect Of Exercise Position On Percent Changes In Serratus Anterior Muscle Thickness, Joseph M. Day 2019 University of Dayton

Effect Of Exercise Position On Percent Changes In Serratus Anterior Muscle Thickness, Joseph M. Day

Joseph Day

Objective: A reliable method for measuring SA thickness with ultrasound imaging has been reported, yet the ability to detect differences in levels of contractility has yet to be established. The purpose of this study was to determine if there are differences in the percent change in thickness of the SA during four different exercise positions performed by healthy individuals.

Design: Observational study

Setting: Laboratory

Participants: Twenty-eight healthy participants, mean age 26 (SD 4, 57% female, 100% right handed)

Methods: Volunteers were positioned in a standardized sitting posture and anatomical landmarks were marked for ultrasound probe positioning. Two resting and two ...


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