Principles Of Radiation Oncology, 2017 University of Massachusetts Medical School
Principles Of Radiation Oncology, Richard S. Pieters, Linda Ding, Harry Bushe, Jesse N. Aronowitz
Cancer Concepts: A Guidebook for the Non-Oncologist
This chapter in Cancer Concepts: a Guidebook for the Non-Oncologist describes the principles of Radiation Oncology. Radiation Oncology utilizes ionizing radiation to treat cancer (and occasionally a few benign conditions). Radiotherapy or radiation therapy (RT) was initially developed in conjunction with diagnostic radiology, but has evolved into a separate specialty. Currently, more than fifty percent of cancer patients undergo RT at some point during the course of their cancer. Most receive treatment with curative intent (radical therapy); however, patients with incurable disease receive shorter, gentler courses of therapy to relieve cancer-induced symptoms.
Evaluating Factors Affecting Clinicians’ Knowledge On Contrast Media: Kenyan Experience, 2017 University of Nairobi
Evaluating Factors Affecting Clinicians’ Knowledge On Contrast Media: Kenyan Experience, Timothy Musila Mutala, Priscilla Nyambura Maina
The Journal of Global Radiology
Purpose: Our study aimed to establish exposure to and level of knowledge about contrast media among non-radiological clinicians and evaluate the contributory factors to the status.
Methods and Materials: A cross-sectional study was conducted between April and December 2015 through interviews using structured questionnaires. We recruited 197 non-radiological clinicians with experience in use of contrast media in their routine practice. They were of different cadres and years of experience, all working in a large referral hospital in Kenya. Levels of basic knowledge on contrast media were evaluated through a scoring system after each clinician responded to the questions provided. We ...
Metastatic Biomarkers In Synovial Sarcoma, 2017 Loma Linda University
Metastatic Biomarkers In Synovial Sarcoma, Rosalia De Necochea-Campion, Lee M. Zuckerman, Hamid R. Mirshahidi, Shahrzad Khosrowpour, Chien-Shing Chen, Saied Mirshahidi
Library Articles and Research
Synovial sarcoma (SS) is an aggressive soft tissue sarcoma (STS) that typically occurs in the extremities near a joint. Metastatic disease is common and usually occurs in the lungs and lymph nodes. Surgical management is the mainstay of treatment with chemotherapy and radiation typically used as adjuvant treatment. Although chemotherapy has a positive impact on survival, the prognosis is poor if metastatic disease occurs. The biology of sarcoma invasion and metastasis remain poorly understood. Chromosomal translocation with fusion of the SYT and SSX genes has been described and is currently used as a diagnostic marker, although the full impact of ...
Bssfp Elliptical Signal Model With Grappa Parallel Imaging, 2017 Brigham Young University
Bssfp Elliptical Signal Model With Grappa Parallel Imaging, Grayson Tarbox, Joseph Valentine, Meredith Taylor, Neal Bangerter
Biomedical Engineering Western Regional Conference
In magnetic resonance imaging, balanced steady-state free precession acquisition using the elliptical signal model geometrical solution can be combined with a GRAPPA parallel imaging reconstruction that preserves phase information to shorten scan times.
Difference Image Ultra-Short Echo Time T2* Mapping Using A 3d Cones Trajectory, 2017 University of California - San Diego
Difference Image Ultra-Short Echo Time T2* Mapping Using A 3d Cones Trajectory, Amin Nazaran, Grayson Tarbox, Randy Hartley, Neal Bangerter
Biomedical Engineering Western Regional Conference
This study introduces a methodology for detecting subtle variations in tissues with very rapid T2* decay through a difference image ultra-short T2* mapping technique using a 3D cones k-space trajectory. The new method is demonstrated in both a normal and surgically repaired Achilles tendon. The resulting UTE images are differenced and T2* values were calculated using a mono-exponential least squares fit on a voxel by voxel basis. The ultrashort T2* maps yield very consistent short T2* values in healthy tendon of 0.3-0.5 ms, while notable variations and elevations of T2* values are observed in surgically repaired tendon.
Innate Immune Pathways Associated With Lung Radioprotection By Soy Isoflavones, 2017 Wayne State University School of Medicine
Innate Immune Pathways Associated With Lung Radioprotection By Soy Isoflavones, Lisa M. Abernathy, Matthew D. Fountain, Michael C. Joiner, Gilda G. Hillman
Oncology Faculty Publications
Introduction: Radiation therapy for lung cancer causes pneumonitis and fibrosis. Soy isoflavones protect against radiation-induced lung injury, but the mediators of radio- protection remain unclear. We investigated the effect of radiation on myeloid-derived suppressor cells (MDSCs) in the lung and their modulation by soy isoflavones for a potential role in protection from radiation-induced lung injury.
Methods: BALB/c mice (5–6 weeks old) received a single 10 Gy dose of thoracic irra- diation and soy isoflavones were orally administrated daily before and after radiation at 1 mg/day. Arginase-1 (Arg-1) and nuclear factor κB (NF-κB) p65 were detected in lung ...
A Simple Economic Conjecture Of Neural Activations, Information Retrieval, And Discount Rates With An Application To Fmri, 2017 University of Kansas Medical Center
A Simple Economic Conjecture Of Neural Activations, Information Retrieval, And Discount Rates With An Application To Fmri, Amanda S. Bruce, John M. Crespi, Jayson Lusk
Economics Working Papers
Brain imaging data gathered from functional magnetic resonance imaging (fMRI) scans in economics is often ad hoc, with little guidance from economic theory. Using a very simple economic product differentiation model with temporal hazard rates and discounting, the authors incorporate percent signal change contrasts from blood-oxygenation-level-dependent (BOLD) scans in a logical manner. Using BOLD signals from brain regions implicated in economic valuation, the research directly tests the hypotheses from the economic conjecture. The empirical test uses a study of consumer decision time regarding milk products. Both simple correlations as well as regression analyses support the hypothesized relationships providing evidence of ...
Chloroquine-Inducible Par-4 Secretion Is Essential For Tumor Cell Apoptosis And Inhibition Of Metastasis, 2017 University of Kentucky
Chloroquine-Inducible Par-4 Secretion Is Essential For Tumor Cell Apoptosis And Inhibition Of Metastasis, Ravshan Burikhanov, Nikhil Hebbar, Sunil K. Noothi, Nidhi Shukla, James Sledziona, Nathália Araujo, Meghana Kudrimoti, Qing Jun Wang, David S. Watt, Danny R. Welch, Jodi Maranchie, Akihiro Harada, Vivek M. Rangnekar
Radiation Medicine Faculty Publications
The induction of tumor suppressor proteins capable of cancer cell apoptosis represents an attractive option for the re-purposing of existing drugs. We report that the anti-malarial drug, chloroquine (CQ), is a robust inducer of Par-4 secretion from normal cells in mice and cancer patients in a clinical trial. CQ-inducible Par-4 secretion triggers paracrine apoptosis of cancer cells and also inhibits metastatic tumor growth. CQ induces Par-4 secretion via the classical secretory pathway that requires the activation of p53. Mechanistically, p53 directly induces Rab8b, a GTPase essential for vesicle transport of Par-4 to the plasma membrane prior to secretion. Our findings ...
Ultrasound Shear Wave Elastography And Liver Fibrosis: A Prospective Multicenter Study, 2017 Aga Khan University
Ultrasound Shear Wave Elastography And Liver Fibrosis: A Prospective Multicenter Study, Joyce Sande, Suleman Verjee, Sudhir Vinayak, Farin Amersi, Munir Ghesani
Imaging & Diagnostic Radiology, East Africa
Aim: To assess the accuracy of shear wave elastography (SWE) alone and in combination with aminotransferase platelet ratio index (APRI) score in the staging of liver fibrosis.
Methods: A multicenter prospective study was conducted to assess the accuracy of SWE (medians) and APRI to predict biopsy results. The analysis focused on distinguishing the different stages of liver disease, namely, F0 from F1-4, F0-1 from F2-4, F0-2 from F3-4 and F0-3 from F4; F0-F1 from F2-F4 being of primary interest. The area under the receiver operating characteristic (AUROC) curve was computed using logistic regression model. The role of age, gender and ...
Ct And Pet Findings For Urachal Adenocarcinoma: A Case Report, 2017 George Washington University
Ct And Pet Findings For Urachal Adenocarcinoma: A Case Report, Merissa Zeman, Ethan Silver, Esma A. Akin
Radiology Faculty Publications
As urachal adenocarcinomas are rare cancers, experience with diagnosing and staging them are limited. To help illustrate CT and PET imaging findings and the role they each play in the workup of urachal adenocarcinomas, we present the case of a 43 y.o. male who was diagnosed at our institution with a T3aN0M0 high grade mucin-producing urachal adenocarcinoma.
Imaging In The Lion City: Singapore Radiology Country Report, 2016 Singapore General Hospital
Imaging In The Lion City: Singapore Radiology Country Report, Lionel Tim-Ee Cheng, Li Hoon Sng, Tchoyoson Choie Cheio Lim, Bien Soo Tan
The Journal of Global Radiology
Singapore is a small tropical island city-state with limited natural resources that has achieved remarkable healthcare outcomes through effective long-term planning and judicious investment in human resources and technology. A full-range of medical imaging services is available in the country, with integrated care delivered to patients through a network of both government and private hospitals. Training in diagnostic radiology, interventional radiology, nuclear medicine and diagnostic radiography continue to evolve in Singapore, with an aim to further increase the range of subspecialty medical imaging services available and address projected challenges for the healthcare system in the future, such as an aging ...
Mammographic Density Assessed On Paired Raw And Processed Digital Images And On Paired Screen-Film And Digital Images Across Three Mammography Systems, 2016 International Agency for Research on Cancer
Mammographic Density Assessed On Paired Raw And Processed Digital Images And On Paired Screen-Film And Digital Images Across Three Mammography Systems, Anya Burton, Graham Byrnes, Jennifer Stone, Rulla M. Tamimi, John Heine, Celine Vachon, Vahit Ozmen, Ana Pereira, Maria Luisa Garmendia, Christopher Scott, John H. Hipwell, Caroline Dickens, Joachim Schüz, Mustafa Erkin Aribal, Kimberly Bertrand, Ava Kwong, Graham G. Giles, John Hopper, Beatriz Pérez Gómez, Marina Pollán, Soo-Hwang Teo, Shivaani Mariapun, Nur Aishah Mohd Taib, Martín Lajous, Ruy Lopez-Riduara, Megan Rice, Isabelle Romieu, Anath Arzee Flugelman, Giske Ursin, Samera Qureshi, Huiyan Ma, Eunjung Lee, Reza Sirous, Mehri Sirous, Jong Won Lee, Jisun Kim, Dorria Salem, Rasha Kamal, Mikael Hartman, Hui Miao, Kee-Seng Chia, Chisato Nagata, Sudhir Vinayak, Rose Ndumia, Carla H. Van Gils, Johanna O. P. Wanders, Beata Peplonska, Agnieszka Bukowska, Steve Allen, Sarah Vinnicombe, Sue Moss, Anna M. Chiarelli, Linda Linton, Gertraud Maskarinec, Martin J. Yaffe, Norman F. Boyd, Isabel Dos-Santos-Silva, Valerie A. Mccormack
Imaging & Diagnostic Radiology, East Africa
Background: Inter-women and intra-women comparisons of mammographic density (MD) are needed in research, clinical and screening applications; however, MD measurements are influenced by mammography modality (screen film/ digital) and digital image format (raw/processed). We aimed to examine differences in MD assessed on these image types.
Methods: We obtained 1294 pairs of images saved in both raw and processed formats from Hologic and General Electric (GE) direct digital systems and a Fuji computed radiography (CR) system, and 128 screen-film and processed CR-digital pairs from consecutive screening rounds. Four readers performed Cumulus-based MD measurements (n = 3441), with each image pair read ...
Intrahepatic Cholangiocarcinoma Presenting As Li-Rads 5 "Hcc", 2016 Division of Gastroenterology and Hepatology, Thomas Jefferson University Hospital
Intrahepatic Cholangiocarcinoma Presenting As Li-Rads 5 "Hcc", Raja K. Dhanekula, Md, Donald Mitchell, Md, John Farber, Md, Ashwin R. Sama, Md, Jesse M. Civan, Md
Department of Gastroenterology and Hepatology Posters
• Hepatocellular Carcinoma (HCC), if within Milan Criteria, is an indication for liver transplantation.
• In contrast, intrahepatic cholangiocarcinoma (IHCC) is a contra-indication to liver transplantation due to high rates of recurrence.
• LI-RADS 5 classification (synonymous with OPTN-5) carries a near 100% positive predictive value for HCC, allowing prioritization of patients for liver transplantation without histological confirmation.
• The “LI-RADS M” classification indicates the presence of malignancy not meeting diagnostic criteria for HCC. In theory, IHCC lesions should be identified as LI-RADS M and not LI-RADS 5.
Proceedings Of 2016 Aurora Scientific Day, 2016 Aurora Health Care
Proceedings Of 2016 Aurora Scientific Day
Journal of Patient-Centered Research and Reviews
This supplement includes select abstracts presented at the 42nd annual Aurora Scientific Day research symposium, held May 25, 2016, in Milwaukee, Wisconsin. Aurora Scientific Day provides a forum for original research conducted by faculty, fellows, residents, students and other allied health professionals affiliated with Aurora Health Care, a not-for-profit health system comprised of integrated hospitals and clinics across eastern Wisconsin and northeastern Illinois.
Assessment Of Work-Integrated Learning: Comparison Of The Usage Of A Grading Rubric By Supervising Radiographers And Teachers, Andrew Kilgour, Peter W. Kilgour, Tania Gerzina, Beverly J. Christian
Professional work-integrated learning (WIL) that integrates the academic experience with off-campus professional experience placements is an integral part of many tertiary courses. Issues with the reliability and validity of assessment grades in these placements suggest that there is a need to strengthen the level of academic rigour of placements in these programmes. This study aims to compare the attitudes to the usage of assessment rubrics of radiographers supervising medical imaging students and teachers supervising pre-service teachers.
WIL placement assessment practices in two programmes, pre-service teacher training (Avondale College of Higher Education, NSW) and medical diagnostic radiography (Faculty of ...
Modern Evaluation Of Abdominal Trauma, 2016 Marshall University
Modern Evaluation Of Abdominal Trauma, Errington C. Thompson, Md, Chadwick J. Knight, Md
Abdominal trauma can be mysterious to some physicians. If patients are evaluated for being stable or unstable, then abdominal trauma can be easily managed. Using a combination of physical examination, ultrasound and CT scans, patients can be quickly and efficiently evaluated.
Traumatic Posterior Tibial Pseudoaneursym: A Rare Late Complication Repaired Conventionally, 2016 Marshall University: School of Medicine
Traumatic Posterior Tibial Pseudoaneursym: A Rare Late Complication Repaired Conventionally, Farzad Amiri, Md, Zachary Sanford, Constantinous Constantinou, Md
Posterior tibial artery pseudoaneurysms are extremely rare. They commonly present as a late complication of trauma or iatrogenic injury. Diagnosis can be elusive. Treatment has been described in the context of open primary repair, endovascular stenting, and coil embolization. There has been increasing interest in the use of endovascular treatment options for this type of injury. If left untreated, pseudoaneurysms can rupture, partially thrombose, expand and cause adjacent local compression and compartment syndrome. The following case presented is of a young gentleman with a posterior tibial pseudoaneurysm incidentally discovered after stepping on glass and the management of his posterior tibial ...
Pulse Shaping For Improved Diagnosis Of Portal Hypertension Using Subharmonic Aided Pressure Estimation, 2016 Thomas Jefferson University
Pulse Shaping For Improved Diagnosis Of Portal Hypertension Using Subharmonic Aided Pressure Estimation, Ipshita Gupta, John R. Eisenbrey, Maria Stanczak, Anush Sridharan, Jaydev K. Dave, Ji-Bin Liu, Christopher Hazard, Colette Shaw, Susan Shamini-Noori, Jonathan M. Fenkel, Michael Soluen, Chandra Sehgal, Kirk Wallace, Flemming Forsberg
Department of Radiology Posters
Subharmonic aided pressure estimation (SHAPE) is based on the inverse relationship between the subharmonic amplitude of contrast microbubbles (obtained by transmitting at the fundamental frequency fo and receiving at fo/2) and the ambient pressure (see fig.1).
A noninvasive ultrasound based pressure estimation procedure would be a major development in the diagnosis of portal hypertension and less invasive than the current catheter-based hepatic venous pressure gradient (HVPG) measurement.
The hypothesis of this study was that portal vein pressures can be monitored and quantified noninvasively in humans using SHAPE.
First selected waveforms were optimized in vitro and in canines, then ...
A Comparison Of Imaging Modalities For The Diagnosis Of Osteomyelitis, 2016 Marshall University, Joan C. Edwards School of Medicine
A Comparison Of Imaging Modalities For The Diagnosis Of Osteomyelitis, Brandon J. Smith, Md, Grant S. Buchanan, Md, Franklin D. Shuler, Md, Phd
Franklin D. Shuler
Osteomyelitis is an increasingly common pathology that often poses a diagnostic challenge to clinicians. Accurate and timely diagnosis is critical to preventing complications that can result in the loss of life or limb. In addition to history, physical exam, and laboratory studies, diagnostic imaging plays an essential role in the diagnostic process. This narrative review article discusses various imaging modalities employed to diagnose osteomyelitis: plain films, computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, bone scintigraphy, and positron emission tomography (PET). Articles were obtained from Pubmed and screened for relevance to the topic of diagnostic imaging for osteomyelitis. The authors ...
Long-Term Biocompatibility, Imaging Appearance And Tissue Effects Associated With Delivery Of A Novel Radiopaque Embolization Bead For Image-Guided Therapy, Karun Sharma, Zainab Bascal, Hugh Kilpatrick, Koorosh Ashrafi, Sean L. Willis, Matthew R. Dreher, Andrew L. Lewis
Pediatrics Faculty Publications
The objective of this study was to undertake a comprehensive long-term biocompatibility and imaging assessment of a new intrinsically radiopaque bead (LC Bead LUMI™) for use in transarterial embolization. The sterilized device and its extracts were subjected to the raft of ISO10993 biocompatibility tests that demonstrated safety with respect to cytotoxicity, mutagenicity, blood contact, irritation, sensitization, systemic toxicity and tissue reaction. Intra-arterial administration was performed in a swine model of hepatic arterial embolization in which 0.22–1 mL of sedimented bead volume was administered to the targeted lobe(s) of the liver. The beads could be visualized during the ...