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Brain Processing Of Contagious Itch In Patients With Atopic Dermatitis, C. Schut, Hideki Mochizuki, Shoshana Grossman, Andrew C. Lin, Chris Conklin, Feroze B. Mohamed, Uwe Gieler, Jorg P. Kupfer, Gil Yosipovitch 2017 Justus-Liebig-University

Brain Processing Of Contagious Itch In Patients With Atopic Dermatitis, C. Schut, Hideki Mochizuki, Shoshana Grossman, Andrew C. Lin, Chris Conklin, Feroze B. Mohamed, Uwe Gieler, Jorg P. Kupfer, Gil Yosipovitch

Department of Radiology Faculty Papers

Several studies show that itch and scratching cannot only be induced by pruritogens like histamine or cowhage, but also by the presentation of certain (audio-) visual stimuli like pictures on crawling insects or videos showing other people scratching. This phenomenon is coined "Contagious itch" (CI). Due to the fact that CI is more profound in patients with the chronic itchy skin disease atopic dermatitis (AD), we believe that it is highly relevant to study brain processing of CI in this group. Knowledge on brain areas involved in CI in AD-patients can provide us with useful hints regarding non-invasive treatments that ...


Ultrasound-Guided Breast Biopsy In The Resource-Limited Setting: An Initial Experience In Rural Uganda, Christopher R. Stark, Kristen K. DeStigter, Alphonsus Matovu, Picho Alli Shadrack 2017 University of Vermont

Ultrasound-Guided Breast Biopsy In The Resource-Limited Setting: An Initial Experience In Rural Uganda, Christopher R. Stark, Kristen K. Destigter, Alphonsus Matovu, Picho Alli Shadrack

The Journal of Global Radiology

Purpose: To describe the methodology and initial experience behind creation of an ultrasoundguided percutaneous breast core biopsy program in rural Uganda.

Methods and Materials: Imaging the World Africa (ITWA) is the registered non-governmental organization division of Imaging the World (ITW), a not-for-profit organization whose primary aim is the integration of affordable high-quality ultrasound into rural health centers. In 2013, ITWA began the pilot phase of an IRB-approved breast care protocol at a rural health center in Uganda. As part of the protocol’s diagnostic arm, an ultrasound-guided percutaneous breast core biopsy training curriculum was implemented in tandem with creation of ...


Mammographic Density And Ageing: A Collaborative Pooled Analysis Of Cross-Sectional Data From 22 Countries Worldwide, Anya Burton, Gertraud Maskarinec, Beatriz Perez-Gomez, Celine Vachon, Hui Miao, Martín Lajous, Ruy López-Ridaura, Megan Rice, Ana Pereira, Maria Luisa Garmendia, Rulla M. Tamimi, Kimberly Bertrand, Ava Kwong, Giske Ursin, Sudhir Vinayak, Rose Ndumia, Shivaani Mariapun 2017 International Agency for Research on Cancer

Mammographic Density And Ageing: A Collaborative Pooled Analysis Of Cross-Sectional Data From 22 Countries Worldwide, Anya Burton, Gertraud Maskarinec, Beatriz Perez-Gomez, Celine Vachon, Hui Miao, Martín Lajous, Ruy López-Ridaura, Megan Rice, Ana Pereira, Maria Luisa Garmendia, Rulla M. Tamimi, Kimberly Bertrand, Ava Kwong, Giske Ursin, Sudhir Vinayak, Rose Ndumia, Shivaani Mariapun

Imaging & Diagnostic Radiology, East Africa

Background:Mammographic density (MD) is one of the strongest breast cancer risk factors. Its age-related characteristics have been studied in women in western countries, but whether these associations apply to women worldwide is not known.

Methods and findings: We examined cross-sectional differences in MD by age and menopausal status in over 11,000 breast-cancer-free women aged 35–85 years, from 40 ethnicity- and location-specific population groups across 22 countries in the International Consortium on Mammographic Density (ICMD). MD was read centrally using a quantitative method (Cumulus) and its square-root metrics were analysed using meta-analysis of group-level estimates and linear regression ...


A Phase Ii Randomized Trial Of Observation Versus Stereotactic Ablative Radiation For Oligometastatic Prostate Cancer (Oriole)., Noura Radwan, Ryan Phillips, Ashley Ross, Steven P. Rowe, Michael A. Gorin, Emmanuel S. Antonarakis, Curtiland Deville, Stephen Greco, Samuel Denmeade, Channing Paller, Daniel Y. Song, Maximilian Diehn, Hao Wang, Michael Carducci, Kenneth J. Pienta, Martin G. Pomper, Theodore L. DeWeese, Adam Dicker, Mario Eisenberger, Phuoc T. Tran 2017 Johns Hopkins University School of Medicine

A Phase Ii Randomized Trial Of Observation Versus Stereotactic Ablative Radiation For Oligometastatic Prostate Cancer (Oriole)., Noura Radwan, Ryan Phillips, Ashley Ross, Steven P. Rowe, Michael A. Gorin, Emmanuel S. Antonarakis, Curtiland Deville, Stephen Greco, Samuel Denmeade, Channing Paller, Daniel Y. Song, Maximilian Diehn, Hao Wang, Michael Carducci, Kenneth J. Pienta, Martin G. Pomper, Theodore L. Deweese, Adam Dicker, Mario Eisenberger, Phuoc T. Tran

Department of Radiation Oncology Faculty Papers

BACKGROUND: We describe a randomized, non-blinded Phase II interventional study to assess the safety and efficacy of stereotactic ablative radiotherapy (SABR) for hormone-sensitive oligometastatic prostate adenocarcinoma, and to describe the biology of the oligometastatic state using immunologic, cellular, molecular, and functional imaging correlates. 54 men with oligometastatic prostate adenocarcinoma will be accrued. The primary clinical endpoint will be progression at 6 months from randomization with the hypothesis that SABR to all metastases will forestall progression by disrupting the metastatic process. Secondary clinical endpoints will include local control at 6 months post-SABR, toxicity and quality of life, and androgen deprivation therapy ...


Ct Scanning Is Sufficient To Clear The Cervical Spine Of Elderly Falls Less Than 5 Feet., Douglas Lehman MD, Rovinder S. Sandhu MD, Leslie Baga BSN, Farheen Hussain MS, John J. Hong MD 2017 Lehigh Valley Health Network

Ct Scanning Is Sufficient To Clear The Cervical Spine Of Elderly Falls Less Than 5 Feet., Douglas Lehman Md, Rovinder S. Sandhu Md, Leslie Baga Bsn, Farheen Hussain Ms, John J. Hong Md

John J. Hong, M.D.

No abstract provided.


A Simple Economic Conjecture Of Neural Activations, Information Retrieval, And Discount Rates With An Application To Fmri, Amanda S. Bruce, John M. Crespi, Jayson Lusk 2017 University of Kansas Medical Center

A Simple Economic Conjecture Of Neural Activations, Information Retrieval, And Discount Rates With An Application To Fmri, Amanda S. Bruce, John M. Crespi, Jayson Lusk

John Crespi

Brain imaging data gathered from functional magnetic resonance imaging (fMRI) scans in economics is often ad hoc, with little guidance from economic theory. Using a very simple economic product differentiation model with temporal hazard rates and discounting, the authors incorporate percent signal change contrasts from blood-oxygenation-level-dependent (BOLD) scans in a logical manner. Using BOLD signals from brain regions implicated in economic valuation, the research directly tests the hypotheses from the economic conjecture. The empirical test uses a study of consumer decision time regarding milk products. Both simple correlations as well as regression analyses support the hypothesized relationships providing evidence of ...


An Open Conversation With Traditional Birth Attendants In Rural Uganda: The Potential For Collaborative Care, Elizabeth D. Yuan, Anjuli R. Cherukuri, Renny Ssembatya, Magdalena R. Naylor, Kristen K. DeStigter 2017 University of Massachusetts Medical School

An Open Conversation With Traditional Birth Attendants In Rural Uganda: The Potential For Collaborative Care, Elizabeth D. Yuan, Anjuli R. Cherukuri, Renny Ssembatya, Magdalena R. Naylor, Kristen K. Destigter

The Journal of Global Radiology

Background: Imaging the World-Africa (ITWA) is a registered non-governmental organization aimed at distributing low-cost ultrasound services at health centres in rural Uganda. Yet, studies demonstrate that the majority of mothers continue to deliver with unregulated traditional birth attendants (TBAs) in their local villages. It has been suggested that the unregulated practices of TBAs has contributed to the high rate of maternal and fetal mortality. A greater understanding of the roles of TBAs in the management of pregnancy and delivery is needed.

Purpose: The purpose of this report is to provide the international community with a greater understanding of TBA practices ...


A Review Of Autoimmune Diseases Associated With Cancer, Patricia Tai, Edward Yu, Kurian Joseph, Thomas Miale 2017 University of Saskatchewan

A Review Of Autoimmune Diseases Associated With Cancer, Patricia Tai, Edward Yu, Kurian Joseph, Thomas Miale

Edward Yu

The focus of this review is on the relationships between autoimmune diseases and cancer from two closely related perspectives: 1.Those autoimmune diseases which are often associated with malignancies. 2.Those prevalent cancers which may increase the risks of developing autoimmune disorders. The review concludes with a brief discussion of some selected innovative approaches to cancer immunotherapy.


A Review Of Autoimmune Diseases Associated With Cancer, Patricia Tai, Edward Yu, Kurian Joseph, Thomas Miale 2017 University of Saskatchewan

A Review Of Autoimmune Diseases Associated With Cancer, Patricia Tai, Edward Yu, Kurian Joseph, Thomas Miale

Edward Yu

The focus of this review is on the relationships between autoimmune diseases and cancer from two closely related perspectives: 1.Those autoimmune diseases which are often associated with malignancies. 2.Those prevalent cancers which may increase the risks of developing autoimmune disorders. The review concludes with a brief discussion of some selected innovative approaches to cancer immunotherapy.


Comparison Of Online 6 Degree-Of-Freedom Image Registration Of Varian Truebeam Cone-Beam Ct And Brainlab Exactrac X-Ray For Intracranial Radiosurgery., Jun Li, Wenyin Shi, David W. Andrews, Maria Werner-Wasik, Bo Lu, Yan Yu, Adam Dicker MD, PhD, Haisong Lui 2017 Thomas Jefferson University

Comparison Of Online 6 Degree-Of-Freedom Image Registration Of Varian Truebeam Cone-Beam Ct And Brainlab Exactrac X-Ray For Intracranial Radiosurgery., Jun Li, Wenyin Shi, David W. Andrews, Maria Werner-Wasik, Bo Lu, Yan Yu, Adam Dicker Md, Phd, Haisong Lui

Department of Radiation Oncology Faculty Papers

PURPOSE: The study was aimed to compare online 6 degree-of-freedom image registrations of TrueBeam cone-beam computed tomography and BrainLab ExacTrac X-ray imaging systems for intracranial radiosurgery.

METHODS: Phantom and patient studies were performed on a Varian TrueBeam STx linear accelerator (version 2.5), which is integrated with a BrainLab ExacTrac imaging system (version 6.1.1). The phantom study was based on a Rando head phantom and was designed to evaluate isocenter location dependence of the image registrations. Ten isocenters at various locations representing clinical treatment sites were selected in the phantom. Cone-beam computed tomography and ExacTrac X-ray images were ...


Enhancement Of The Abscopal Effect In Radiotherapy By In-Situ Delivered Cd40 Antibody: Pancreatic Adenocarcinoma Model, Sayeda Yasmin-Karim, Michele Moreau, Wilfred Ngwa 2017 Harvard Medical School

Enhancement Of The Abscopal Effect In Radiotherapy By In-Situ Delivered Cd40 Antibody: Pancreatic Adenocarcinoma Model, Sayeda Yasmin-Karim, Michele Moreau, Wilfred Ngwa

UMass Center for Clinical and Translational Science Research Retreat

Metastasis is the cause of death in most cancers. It has been observed by Mole and others that radiotherapy at one site may lead to regression of metastatic cancer at other sites, which were not irradiated, this phenomenon is called ‘abscopal’ effect. Unfortunately, this regression is not predictable.

Few studies observed some enhancement by systemic application of immunoadjuvants, which also has limited application because of generalized adverse effect. The purpose of this study is to evaluate the enhancing and abscopal effect of radiotherapy by in-situ delivered anti-CD40 in the treatment of pancreatic cancer.

A syngeneic mouse model of pancreatic adenocarcinoma ...


Imaging Probes For Detecting Inflammation In The Mouse Model Of Type 1 Diabetes, Toloo Taghian, Suresh Gupta, Adam J. Dixon, Surong Zhang, Alexei A. Bogdanov 2017 University of Massachusetts Medical School

Imaging Probes For Detecting Inflammation In The Mouse Model Of Type 1 Diabetes, Toloo Taghian, Suresh Gupta, Adam J. Dixon, Surong Zhang, Alexei A. Bogdanov

UMass Center for Clinical and Translational Science Research Retreat

Non-invasive imaging of early signs of inflammation of endocrine pancreas is of importance due to a generally late clinical diagnosis of type 1 diabetes (T1D). Seventy-80% of insulin producing beta-cells could be already lost prior to the onset of clinical symptoms. Therefore, monitoring these early changes including increased vascular permeability of pancreas and activation of pro-inflammatory signaling pathways will aid in early diagnosis and timing of therapy. We have developed and tested superparamagnetic nanoparticles (NPs) with strong photoacoustic signal for detecting potential permeability changes in the pancreas of streptozotocin (STZ)- induced mouse model of T1D. These biocompatible gold/iron-oxide NPs ...


Sensitivity Of Diffuse Reflectance Spectroscopy To Dose- And Depth-Dependent Changes In Tumor Oxygenation After Radiation Therapy, Daria Semeniak 2017 University of Arkansas, Fayetteville

Sensitivity Of Diffuse Reflectance Spectroscopy To Dose- And Depth-Dependent Changes In Tumor Oxygenation After Radiation Therapy, Daria Semeniak

Theses and Dissertations

Along with chemotherapy, immunotherapy, and surgery, radiotherapy is one of the most common treatments used against cancer. Around 50% of all cancer patients undergo radiation therapy. While for some patients radiotherapy works efficiently and lead to a complete cancer disappearance, for others treatment outcome may be less favorable due to radioresistance processes happening within a tumor on the molecular level. Radioresistance remains a big challenge for modern oncology. The ability to identify radioresistance at the early stage of radiotherapy would help physicians to improve therapy efficiency. At the current moment, despite the rapid progress in cancer understanding and diagnostic modalities ...


Interventional Radiology Readiness Assessment Tool For Global Health, Aaron D. Kline, Robert G. Dixon, Megan K. Brown, Melissa P. Culp 2017 University of North Carolina at Chapel Hill

Interventional Radiology Readiness Assessment Tool For Global Health, Aaron D. Kline, Robert G. Dixon, Megan K. Brown, Melissa P. Culp

The Journal of Global Radiology

The Interventional Radiology Readiness Assessment Tool for Global Health is a new tool to methodically evaluate the environment of a medical institution for interventional radiology services given the existing infrastructure. Global health provides an exciting opportunity for interventional radiology to impact health outcomes in developing countries. A systematic and thoughtful approach to integrating interventional radiology services in the health care institutions of resource poor countries is needed in order to maximize global health efforts and outcomes.

The IR Readiness Assessment Tool is available as on online form and in PDF format under "Additional Files" below.


Quality Assurance Guidelines For Superficial Hyperthermia Clinical Trials : Ii. Technical Requirements For Heating Devices., Hana Dobšíček Trefná, Johannes Crezee, Manfred Schmidt, Dietmar Marder, Ulf Lamprecht, Michael Ehmann, Jacek Nadobny, Josefin Hartmann, Nicolleta Lomax, Sultan Abdel-Rahman, Sergio Curto, Akke Bakker, Mark D. Hurwitz, Chris J. Diederich, Paul R. Stauffer, Gerard C. Van Rhoon 2017 Chalmers University of Technology

Quality Assurance Guidelines For Superficial Hyperthermia Clinical Trials : Ii. Technical Requirements For Heating Devices., Hana Dobšíček Trefná, Johannes Crezee, Manfred Schmidt, Dietmar Marder, Ulf Lamprecht, Michael Ehmann, Jacek Nadobny, Josefin Hartmann, Nicolleta Lomax, Sultan Abdel-Rahman, Sergio Curto, Akke Bakker, Mark D. Hurwitz, Chris J. Diederich, Paul R. Stauffer, Gerard C. Van Rhoon

Department of Radiation Oncology Faculty Papers

Quality assurance (QA) guidelines are essential to provide uniform execution of clinical trials with uniform quality hyperthermia treatments. This document outlines the requirements for appropriate QA of all current superficial heating equipment including electromagnetic (radiative and capacitive), ultrasound, and infrared heating techniques. Detailed instructions are provided how to characterize and document the performance of these hyperthermia applicators in order to apply reproducible hyperthermia treatments of uniform high quality. Earlier documents used specific absorption rate (SAR) to define and characterize applicator performance. In these QA guidelines, temperature rise is the leading parameter for characterization of applicator performance. The intention of this ...


Sonoelastography Of The Common Flexor Tendon Of The Elbow With Histologic Agreement: A Cadaveric Study., Andrea S Klauser, Mathias J Pamminger, Ethan J. Halpern, Mohamed M H Abd Ellah, Bernhard Moriggl, Mihra S Taljanovic, Christian Deml, Judith Sztankay, Guenter Klima, Leonhard Gruber, Werner R Jaschke 2017 Department of Radiology, Medical University of Innsbruck

Sonoelastography Of The Common Flexor Tendon Of The Elbow With Histologic Agreement: A Cadaveric Study., Andrea S Klauser, Mathias J Pamminger, Ethan J. Halpern, Mohamed M H Abd Ellah, Bernhard Moriggl, Mihra S Taljanovic, Christian Deml, Judith Sztankay, Guenter Klima, Leonhard Gruber, Werner R Jaschke

Department of Radiology Faculty Papers

Purpose To determine the correlation of the results of conventional B-mode ultrasonography (US) and compression sonoelastography with histologic results in common flexor tendons of the elbow in human cadavers. Materials and Methods Twenty-five common flexor tendons were evaluated in 16 fresh, unembalmed cadavers of 11 women with a median age of 85 years (range, 71-101 years) and five men with a median age of 78 years (range, 70-88 years). Informed consent was provided according to the last will of the donors. B-mode US results were classified as grade 1, normal tendon with homogeneous fibrillar pattern; grade 2, tendon thickening or ...


Value Of Superb Microvascular Imaging Ultrasonography In The Diagnosis Of Carpal Tunnel Syndrome: Compared With Color Doppler And Power Doppler., Jie Chen, Li Chen, Lei Wu, Rui Wang, Ji-Bin Liu, Bing Hu, Li-Xin Jiang 2017 Shanghai Institute of Ultrasound in Medicine

Value Of Superb Microvascular Imaging Ultrasonography In The Diagnosis Of Carpal Tunnel Syndrome: Compared With Color Doppler And Power Doppler., Jie Chen, Li Chen, Lei Wu, Rui Wang, Ji-Bin Liu, Bing Hu, Li-Xin Jiang

Department of Radiology Faculty Papers

The aim of this study was to compare the value of superb microvascular imaging (SMI) in carpal tunnel syndrome (CTS) with that of color Doppler ultrasonography (CDUS) and power Doppler ultrasonography (PDUS).Fifty patients with symptomatic CTS and 25 healthy volunteers were enrolled. The cross-sectional area (CSA), CDUS score, PDUS score, and SMI score of the median nerve (MN) at the carpal tunnel were recorded. The value of different ultrasonography (US) diagnostic strategies was calculated.The blood flow display ratio in the MN of the healthy volunteers had no statistical difference between CDUS, PDUS, and SMI (20%, 32%, and 48 ...


Rosai-Dorfman Disease Of The Breast, Eileen E. Delaney, Anne C. Larkin, Sue MacMaster, Ali Sakhdari, Carolynn M. Debenedictis 2017 University of Massachusetts Medical School

Rosai-Dorfman Disease Of The Breast, Eileen E. Delaney, Anne C. Larkin, Sue Macmaster, Ali Sakhdari, Carolynn M. Debenedictis

Radiology Publications and Presentations

Rosai-Dorfman disease (also known as sinus histiocytosis with massive lymphadenopathy) is a rare benign proliferative disorder of histiocytes that typically involves the lymph nodes and can also involve extranodal sites. Rosai-Dorfman disease confined to the breast is extremely rare, but important to recognize as it can mimic malignancy. We present the case of a 63-year-old woman who presented with a palpable breast lump that was highly suspicious for malignancy based on mammogram and ultrasound appearance. Biopsy revealed inflammatory tissue with lymphoplasmacytic and histiocytic predominance. The diagnosis of Rosai-Dorfman was made based on characteristic staining of histiocytes with S-100 and the ...


Breast Lesions Detected Via Breast Specific Gamma Imaging: Descriptor Characteristics And Positive Predictive Value, Jason Ching, Rachel Brem 2017 George Washington University

Breast Lesions Detected Via Breast Specific Gamma Imaging: Descriptor Characteristics And Positive Predictive Value, Jason Ching, Rachel Brem

GW Research Days 2016 - Present

Background:

Breast Specific Gamma Imaging (BSGI) is increasingly being used as a diagnostic tool for the detection of breast cancer, using technetium 99m sestamibi to identify physiological differences between cancerous and normal breast tissue. Our study retrospectively evaluates pathologic correlates to positive BSGI findings in the detection of breast cancer.

Methods:

A retrospective review was performed of patients with positive BSGI examinations (200 total) during a 1-year period. Using biopsy/surgical pathology or 2 years mammography/ultrasound/MRI follow-up as correlation, we determined the positive predictive values of BSGI findings when categorized by: (i) character of suspicious region [mass, non-mass ...


Needs Assessment Of Pediatric Radiological Equipment And Cross-Cultural Investigation Into Parental Empowerment In Pediatric Radiology Program Development In The Kingdom Of Bhutan, Danielle Canter 2017 George Washington University

Needs Assessment Of Pediatric Radiological Equipment And Cross-Cultural Investigation Into Parental Empowerment In Pediatric Radiology Program Development In The Kingdom Of Bhutan, Danielle Canter

GW Research Days 2016 - Present

Background:

Bhutan is a magnificent mountainous country hugged by India to the east and west and by China to the North and South. This peaceful nestled country faces challenges in combating non-communicable diseases due to the lack of radiological equipment necessary for early diagnosis. Prior to implementation of these medical devices, it is imperative to investigate the cultural attitudes, beliefs, and infrastructure, to ensure successful integration. Bhutan is beginning to implement a pediatric radiology program for the nation with the assistance of ABAH Foundation and RAD-AID International, both of whom partnered with graduate students at George Washington University School of ...


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