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Synthetic Magnetic Resonance Imaging Revisited, Ranjan Maitra, John J. Riddles 2016 Iowa State University

Synthetic Magnetic Resonance Imaging Revisited, Ranjan Maitra, John J. Riddles

Ranjan Maitra

Synthetic magnetic resonance (MR) imaging is an approach suggested in the literature to predict MR images at different design parameter settings from at least three observed MR scans. However, performance is poor when no regularization is used in the estimation and otherwise computationally impractical to implement for three-dimensional imaging methods. We propose a method which accounts for spatial context in MR images by the imposition of a Gaussian Markov Random Field (MRF) structure on a transformation of the spin-lattice relaxation time, the spin-spin relaxation time and the proton density at each voxel. The MRF structure is specified through a Matrix ...


Ultrasound-Guided Intralesional Bleomycin Injection (Ibi) For Treatment Of Cutaneous Hemangiomas And Vascular Malformations, Yousuf Memon, Nuzhat I. Malik, Naveed Anjum, S. Kamran Ahmed, Sadaf Saeed 2016 The Indus Hospital

Ultrasound-Guided Intralesional Bleomycin Injection (Ibi) For Treatment Of Cutaneous Hemangiomas And Vascular Malformations, Yousuf Memon, Nuzhat I. Malik, Naveed Anjum, S. Kamran Ahmed, Sadaf Saeed

The Journal of Global Radiology

Purpose: To report the therapeutic outcome of ultrasound-guided intralesional injection of bleomycin in the treatment of cutaneous hemangiomas and vascular malformations.

Material & Methods: The medical records of patients with cutaneous hemangiomas and vascular malformations treated with the intralesional injection of bleomycin under ultrasound guidance between August 2009 and June 2013 at the Indus Hospital, Karachi were reviewed retrospectively using a computerized medical record information management system. Data were extracted using a pre-coded performa that included patient demographics, type and location of lesion, number of treatments, presenting/pre- and post-treatment clinical symptoms (pain, swelling, heaviness, size, discoloration), ultrasound appearance and vascularity, and post-treatment side effects. The dose range of bleomycin was 0.5-1.0 mg/kg, but not exceeding 15 mg in a single session. A maximum of four treatments were given in any given patient except for one, who presented with recurrence after a year of complete resolution. Therapeutic outcome was determined using review of ultrasound images and recorded clinical assessment. Treatment response was categorized as: (i) complete resolution [more than 90% reduction]; (ii) substantial reduction [more than 50% reduction]; (iii) mild reduction [25% reduction]; or, (iv) no improvement [ < 10% reduction].

Results: A total of 30 patients (16 female, 14 male), ranging in age from 8 months to 48 years (mean age 10.2 years), were treated from 2009 to 2013. There were 23 hemangiomas. Seven were vascular malformations, of which five were lymphatic malformations and two were venous malformations. Twenty-eight lesions were located in the head and neck region, and two were ...


Predictive Biomarkers Of Cellular Radiosensitivity For Clinical Radiotherapy Treatment, Lisa White 2016 Dublin Institute of Technology

Predictive Biomarkers Of Cellular Radiosensitivity For Clinical Radiotherapy Treatment, Lisa White

Doctoral

Radiotherapy is prescribed to more than 50% of cancer patients during their treatment schedule. Due to intrinsic factors, individual variation in response exists, which will result in side effects or toxicity in a number of patients. Therefore, development of an assay or biomarker for the prediction and assessment of radiosensitivity among cancer patients undergoing radiotherapy would be beneficial. Such an assay would limit toxicities and facilitate dose-escalation for those patients who require it. Assays for predicting intrinsic cellular radiosensitivity remains as the established G2 chromosomal radiosensitivity and most promising, γH2AX foci assay. They can be applied to blood samples from ...


Ultrasonography Of The Scrotum In Adults, Anna L. Kuhn, Eduardo Scortegagna, Kristina M. Nowitzki, Young H. Kim 2016 University of Massachusetts Medical School

Ultrasonography Of The Scrotum In Adults, Anna L. Kuhn, Eduardo Scortegagna, Kristina M. Nowitzki, Young H. Kim

Radiology Publications and Presentations

Ultrasonography is the ideal noninvasive imaging modality for evaluation of scrotal abnormalities. It is capable of differentiating the most important etiologies of acute scrotal pain and swelling, including epididymitis and testicular torsion, and is the imaging modality of choice in acute scrotal trauma. In patients presenting with palpable abnormality or scrotal swelling, ultrasonography can detect, locate, and characterize both intratesticular and extratesticular masses and other abnormalities. A 12-17 MHz high frequency linear array transducer provides excellent anatomic detail of the testicles and surrounding structures. In addition, vascular perfusion can be easily assessed using color and spectral Doppler analysis. In most ...


Non-Invasive Imaging For The Assessment Of Cardiac Dose And Function Following Focused External Beam Irradiation, Omar El-Sherif 2016 The University of Western Ontario

Non-Invasive Imaging For The Assessment Of Cardiac Dose And Function Following Focused External Beam Irradiation, Omar El-Sherif

Electronic Thesis and Dissertation Repository

Technological advances in imaging and radiotherapy have led to significant improvement in the survival rate of breast cancer patients. However, a larger proportion of patients are now exhibiting the less understood, latent effects of incidental cardiac irradiation that occurs during left-sided breast radiotherapy. Here, we examine the utility of four-dimensional computed tomography (4D-CT) for the accurate assessment of cardiac dose; and a hybrid positron emission tomography (PET) magnetic resonance imaging (MRI) system to longitudinally study radiation-induced cardiac effects in a canine model.

Using 4D-CT and deformable dose accumulation, we assessed the variation caused by breathing motion in the estimated dose ...


Redefining Budd-Chiari Syndrome: A Systematic Review, Naomi Shin, Young H. Kim, Hao Xu, Hai-Bin Shi, Qing-Qiao Zhang, Jean Paul Colon Pons, Ducksoo Kim, Yi Xu, Fei-Yun Wu, Samuel Han, Byung-Boong Lee, Lin-Sun Li 2016 University of Massachusetts Medical School

Redefining Budd-Chiari Syndrome: A Systematic Review, Naomi Shin, Young H. Kim, Hao Xu, Hai-Bin Shi, Qing-Qiao Zhang, Jean Paul Colon Pons, Ducksoo Kim, Yi Xu, Fei-Yun Wu, Samuel Han, Byung-Boong Lee, Lin-Sun Li

Radiology Publications and Presentations

AIM: To re-examine whether hepatic vein thrombosis (HVT) (classical Budd-Chiari syndrome) and hepatic vena cava-Budd Chiari syndrome (HVC-BCS) are the same disorder.

METHODS: A systematic review of observational studies conducted in adult subjects with primary BCS, hepatic vein outflow tract obstruction, membranous obstruction of the inferior vena cava (IVC), obliterative hepatocavopathy, or HVT during the period of January 2000 until February 2015 was conducted using the following databases: Cochrane Library, CINAHL, MEDLINE, PubMed and Scopus.

RESULTS: Of 1299 articles identified, 26 were included in this study. Classical BCS is more common in women with a pure hepatic vein obstruction (49 ...


Advanced Mri Center: A 3 Tesla Magnetic Resonance System For Preclinical, Translational And Clinical Imaging Studies, Letterio S. Politi, Shaokuan Zheng, Matthew J. Gounis 2016 University of Massachusetts Medical School

Advanced Mri Center: A 3 Tesla Magnetic Resonance System For Preclinical, Translational And Clinical Imaging Studies, Letterio S. Politi, Shaokuan Zheng, Matthew J. Gounis

UMass Center for Clinical and Translational Science Research Retreat

The Advanced MRI Center, located in the UMass Medical School building, is a research core facility providing the latest magnetic resonance imaging and spectroscopy capabilities to UMass scientists. It is equipped with a Philips Achieva 3.0T X-series whole-body scanner and radiofrequency coils for studying all organs of the human body, and small and large animals, such as mice, rats, rabbits, dogs, sheep and non-human primates. The center also includes a radiofrequency coil lab, a nurses’ station, two patient holding rooms and two patient changing rooms.

The Center’s specialized techniques are able to elucidate functional, physiological and biochemical information ...


Library Online Resources Of Special Interest Radiologic Sciences, Information Services 2016 Scott Memorial Library, Thomas Jefferson University

Library Online Resources Of Special Interest Radiologic Sciences, Information Services

Electronic Handouts

E-books and databases for Radiologic Sciences.


Pilot Study Of A Resource-Appropriate Strategy For Downstaging Breast Cancer In Rural Uganda, Alphonsus Matovu, John R. Scheel, Picho Alli Shadrack, Renny Ssembatya, Angela Njeri, Moses Galukande, Kristen K. DeStigter 2016 Mubende Regional Referral Hospital

Pilot Study Of A Resource-Appropriate Strategy For Downstaging Breast Cancer In Rural Uganda, Alphonsus Matovu, John R. Scheel, Picho Alli Shadrack, Renny Ssembatya, Angela Njeri, Moses Galukande, Kristen K. Destigter

The Journal of Global Radiology

Breast cancer incidence and mortality are rapidly increasing in low- and middle-income countries like Uganda. Shifting the proportion of women presenting with late-stage breast cancer to early-stage breast cancer (downstaging) at the time of diagnosis would substantially improve survival and efficient use of available resources. Imaging The World (ITW) conducted a pilot study in Uganda where trained village health teams (VHTs) promoted breast cancer awareness in the Kamuli District (Uganda). As a result, 212 women with self-detected lumps presented to the community health center level III (Nawanyago HCIII) for a clinical breast examination (CBE). Patients with masses on CBE were ...


Mr Imaging Findings In Xp21.2 Duplication Syndrome, Matthew T. Whitehead, Guy Helman, Andrea L. Gropman 2016 George Washington University

Mr Imaging Findings In Xp21.2 Duplication Syndrome, Matthew T. Whitehead, Guy Helman, Andrea L. Gropman

Radiology Faculty Publications

Xp21.2 duplication syndrome is a rare genetic disorder of undetermined prevalence and clinical relevance. As the use of chromosomal microarray has become first line for the work-up of childhood developmental delay, more gene deletions and duplications have been recognized. To the best of our knowledge, the imaging findings of Xp21.2 duplication syndrome have not been reported. We report a case of a 33 month-old male referred for developmental delay that was found to have an Xp21.2 duplication containing IL1RAPL1 and multiple midline brain malformations.


Neuroimaging Of Cerebral Venous Thrombosis, Mohammad Wasay, Muhammad Azeemuddin 2016 Aga Khan University

Neuroimaging Of Cerebral Venous Thrombosis, Mohammad Wasay, Muhammad Azeemuddin

Mohammad Wasay

Early and accurate diagnosis of cerebral venous thrombosis (CVT) is possible with the help of computed tomography (CT) scan and magnetic resonance imaging (MRI). Empty Δ sign on postcontrast CT is present in only up to 30% of the cases. The role of CT venography is not yet established, but it is emerging as an effective modality for diagnosis of CVT. T2* MRI sequence is superior to spin echo in detecting CVT and small hemor rhages. MR venography is considered the technique of choice for diagnosis and follow-up of CVT, but in certain cases, MRI could be superior as it ...


Modern Evaluation Of Abdominal Trauma, Errington C. Thompson, MD, Chadwick J. Knight, MD 2016 Marshall University

Modern Evaluation Of Abdominal Trauma, Errington C. Thompson, Md, Chadwick J. Knight, Md

Marshall Journal of Medicine

Abdominal trauma can be mysterious to some physicians. If patients are evaluated for being stable or unstable, then abdominal trauma can be easily managed. Using a combination of physical examination, ultrasound and CT scans, patients can be quickly and efficiently evaluated.


Development Of A Temperature Sensitive Face Mask For Identification And Triage Of Febrile Patients, Annemarie Daecher, Flemming Forsberg, John R. Eisenbrey 2016 Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA

Development Of A Temperature Sensitive Face Mask For Identification And Triage Of Febrile Patients, Annemarie Daecher, Flemming Forsberg, John R. Eisenbrey

Department of Radiology Posters

Abstract:

Many infectious diseases are most transmittable when the carrier is presenting with fever. We propose a disposable face mask that changes color as an indicator of fever to provide hospitals with a quick and inexpensive method for triaging infected patients while limiting exposure to others. Two blue thermochromatic dyes which transition to white at 89°F and 92°F were mixed with white paint and applied to 5 types of disposable face masks. During trials, a wearer either sat at rest or ran on a treadmill for 20 minutes and images were obtained every 5 minutes with a thermal ...


Oncologic Imaging, John J. Shim, Andrew Chen 2016 David Geffen School of Medicine at UCLA

Oncologic Imaging, John J. Shim, Andrew Chen

Cancer Concepts: A Guidebook for the Non-Oncologist

Imaging is an integral part of the multidisciplinary management of cancer. Radiographic techniques are indispensable for proper staging of cancers and evaluation of the response of tumors to treatment. A wide variety of imaging modalities is available to clinicians. This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist will introduce the role of radiology in the diagnosis and treatment of cancer.


Quantitative Assessment Of Device-Clot Interaction For Stent Retriever Thrombectomy, Kajo van der Marel, Ju-Yu Chueh, Olivia W. Brooks, Robert M. King, Miklos G. Marosfoi, Erin T. Langan, Sarena L. Carniato, Matthew J. Gounis, Raul G. Nogueira, Ajit S. Puri 2016 University of Massachusetts Medical School

Quantitative Assessment Of Device-Clot Interaction For Stent Retriever Thrombectomy, Kajo Van Der Marel, Ju-Yu Chueh, Olivia W. Brooks, Robert M. King, Miklos G. Marosfoi, Erin T. Langan, Sarena L. Carniato, Matthew J. Gounis, Raul G. Nogueira, Ajit S. Puri

Radiology Publications and Presentations

PURPOSE: Rapid revascularization in emergent large vessel occlusion with endovascular embolectomy has proven clinical benefit. We sought to measure device-clot interaction as a potential mechanism for efficient embolectomy.

METHODS: Two different radiopaque clot models were injected to create a middle cerebral artery occlusion in a patient-specific vascular phantom. A radiopaque stent retriever was deployed within the clot by unsheathing the device or a combination of unsheathing followed by pushing the device (n=8/group). High-resolution cone beam CT was performed immediately after device deployment and repeated after 5 min. An image processing pipeline was created to quantitatively evaluate the volume ...


Risk Of Distal Embolization With Stent Retriever Thrombectomy And Adapt, Ju-Yu Chueh, Ajit S. Puri, Ajay K. Wakhloo, Matthew J. Gounis 2016 University of Massachusetts Medical School

Risk Of Distal Embolization With Stent Retriever Thrombectomy And Adapt, Ju-Yu Chueh, Ajit S. Puri, Ajay K. Wakhloo, Matthew J. Gounis

Radiology Publications and Presentations

BACKGROUND: There is a discrepancy in clinical outcomes and the achieved recanalization rates with stent retrievers in the endovascular treatment of ischemic stroke. It is our hypothesis that procedural release of embolic particulate may be one contributor to poor outcomes and is a modifiable risk. The goal of this study is to assess various treatment strategies that reduce the risk of distal emboli.

METHODS: Mechanical thrombectomy was simulated in a vascular phantom with collateral circulation. Hard fragment-prone clots (HFC) and soft elastic clots (SECs) were used to generate middle cerebral artery (MCA) occlusions that were retrieved by the Solitaire FR ...


Targeted Scvegf/(177)Lu Radiopharmaceutical Inhibits Growth Of Metastases And Can Be Effectively Combined With Chemotherapy, Mary Rusckowski, Yuzhen Wang, Francis G. Blankenberg, Zoia Levashova, Marina V. Backer, Joseph M. Backer 2016 University of Massachusetts Medical School

Targeted Scvegf/(177)Lu Radiopharmaceutical Inhibits Growth Of Metastases And Can Be Effectively Combined With Chemotherapy, Mary Rusckowski, Yuzhen Wang, Francis G. Blankenberg, Zoia Levashova, Marina V. Backer, Joseph M. Backer

Radiology Publications and Presentations

BACKGROUND: scVEGF/(177)Lu is a novel radiopharmaceutical targeted by recombinant single-chain (sc) derivative of vascular endothelial growth factor (VEGF) that binds to and is internalized by vascular endothelial growth factor receptors (VEGFR). scVEGF/(177)Lu potential as adjuvant and neoadjuvant anti-angiogenic therapy was assessed in metastatic and orthotopic mouse models of triple-negative breast cancer.

METHODS: Metastatic lesions in Balb/c mice were established by intracardiac injection of luciferase-expressing 4T1luc mouse breast carcinoma cells. Mice with metastatic lesions received single intravenous (i.v.) injection of well-tolerated dose of scVEGF/(177)Lu (7.4 MBq/mouse) at day 8 after 4T1luc ...


Hyperspectral Imaging For Burn Depth Assessment In An Animal Model, Michael S. Chin, Oksana Olegovna Babchenko, Jorge Lujan-Hernandez, Lisa Nobel, Ronald A. Ignotz, Janice F. Lalikos 2016 University of Massachusetts Medical School

Hyperspectral Imaging For Burn Depth Assessment In An Animal Model, Michael S. Chin, Oksana Olegovna Babchenko, Jorge Lujan-Hernandez, Lisa Nobel, Ronald A. Ignotz, Janice F. Lalikos

Senior Scholars Program

Differentiating between superficial and deep-dermal (DD) burns remains challenging. Superficial-dermal burns heal with conservative treatment; DD burns often require excision and skin grafting. Decision of surgical treatment is often delayed until burn depth is definitively identified. This study's aim is to assess the ability of hyperspectral imaging (HSI) to differentiate burn depth.

METHODS: Thermal injury of graded severity was generated on the dorsum of hairless mice with a heated brass rod. Perfusion and oxygenation parameters of injured skin were measured with HSI, a noninvasive method of diffuse reflectance spectroscopy, at 2 minutes, 1, 24, 48 and 72 hours after ...


Workplace Access To Journals: Is It Sufficient To Support Quality Healthcare Practice In Medical Imaging Workers?, Madeleine C. Shanahan 2016 RMIT University, School of Medical Sciences

Workplace Access To Journals: Is It Sufficient To Support Quality Healthcare Practice In Medical Imaging Workers?, Madeleine C. Shanahan

Internet Journal of Allied Health Sciences and Practice

Introduction: Journals are important tools for disseminating new knowledge to health professionals. The purpose of this study was to investigate workplace access to journals. Medical imaging workers (MIWs) were the allied health professional group studied. Methods: A two phase sequential exploratory mixed methods design was adopted to collect data from MIWs to develop a list of professionally relevant journals and to examine accessibility of journals across the profession. In addition, the derived list of journals was further examined to determine open access and open article availability. Results: Twenty-seven percent (n=88) of survey respondents (N=362) reported that they have ...


Interrater Reliability Of Quantitative Ultrasound Using Force Feedback Among Examiners With Varied Levels Of Experience, Michael O. Harris-Love, Catheeja Ismail, Reza Monfaredi, Haniel J. Hernandez, Donte Pennington, Paula Woletz, Valerie McIntosh, Bernadette Adams, Marc R. Blackman 2016 George Washington University

Interrater Reliability Of Quantitative Ultrasound Using Force Feedback Among Examiners With Varied Levels Of Experience, Michael O. Harris-Love, Catheeja Ismail, Reza Monfaredi, Haniel J. Hernandez, Donte Pennington, Paula Woletz, Valerie Mcintosh, Bernadette Adams, Marc R. Blackman

Exercise and Nutrition Sciences Faculty Publications

Background. Quantitative ultrasound measures are influenced by multiple external factors including examiner scanning force. Force feedback may foster the acquisition of reliable morphometry measures under a variety of scanning conditions. The purpose of this study was to determine the reliability of force-feedback image acquisition and morphometry over a range of examiner-generated forces using a muscle tissuemimicking ultrasound phantom.

Methods. Sixty material thickness measures were acquired from a muscle tissue mimicking phantom using B-mode ultrasound scanning by six examiners with varied experience levels (i.e., experienced, intermediate, and novice). Estimates of interrater reliability and measurement error with force feedback scanning were ...


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