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Characterizing Statin Use Among Prediabetic Patients With Predictive Analytics, Alexandra Gentile 2020 University of Arkansas, Fayetteville

Characterizing Statin Use Among Prediabetic Patients With Predictive Analytics, Alexandra Gentile

Industrial Engineering Undergraduate Honors Theses

Diabetes is one of the leading causes of death in the United States and can cause severe impairments to those diagnosed. Prediabetes is a state when a patient has higher fasting plasma glucose levels than a non-diabetic person but is not quite high enough to be considered diabetes. Both diabetic and prediabetic patients are at higher risk for cardiovascular diseases (CVD), which is the leading cause of death in the United States. The primary form for prevention and treatment of CVD is through statin therapy. Statins are a class of medications used to treat and prevent CVD by limiting cholesterol ...


Acute Ingestion Of A Ketone Ester Beverage And Its Impact Upon Glycaemic Control, Appetite, And Food Intake, Beau Pennington, Richard Webb 2020 Ouachita Baptist University

Acute Ingestion Of A Ketone Ester Beverage And Its Impact Upon Glycaemic Control, Appetite, And Food Intake, Beau Pennington, Richard Webb

Scholars Day Conference

Ketosis is a state in which ketone bodies are hepatically produced, which can lead to weight loss, appetite suppression, and improved glycaemic control. Reaching a state of ketosis can be difficult to attain and can be induced by fasting or restricting dietary carbohydrates. Exogenous ketones in the form of ketone monoesters have been shown to efficiently induce a state of ketosis. Ketone monoesters are synthetic molecules. The aim of the study was to determine the impact of the acute ingestion of a ketone ester beverage upon appetite, food intake, and glycaemic control. Participants ingested the ketone ester beverage and measurements ...


The Implementation Of Diabetic Foot Care Into Primary Care, Shelby D. Strong 2020 Valparaiso University

The Implementation Of Diabetic Foot Care Into Primary Care, Shelby D. Strong

Evidence-Based Practice Project Reports

Diabetes mellitus (DM) is one of the most common metabolic diseases worldwide. It can lead to complications in many parts of the body and can increase overall risk of dying prematurely (World Health Organization (WHO), 2016). Diabetic peripheral neuropathy (DPN) in the feet is one of the most frequent complications of DM (Wang et al., 2017). Other lower extremity complications which can occur as a result of diabetic foot complication (DFC) includes peripheral artery disease (PAD), infection, ulcer and amputation. One of the obstacles for preventing (DFC) is the lack of examinations of the feet in clinical practice (Feitosa et ...


The Spectrum Of Large Adrenal Masses: A Case Series, Jo Cooke-Barber, Sarah E. Hatef, Analise McGreal, Andrew Schwemmer, Christopher Senkowski 2020 Memorial Health University Medical Center

The Spectrum Of Large Adrenal Masses: A Case Series, Jo Cooke-Barber, Sarah E. Hatef, Analise Mcgreal, Andrew Schwemmer, Christopher Senkowski

HCA Healthcare Journal of Medicine

Background: Adrenocortical carcinoma (ACC) is a rare malignancy that is challenging to diagnose and has important implications for surgeons who approach this disease. Despite its rarity, it must always be in the differential diagnosis when investigating and treating large adrenal masses. We aim to demonstrate the complexities of this disease through a review of five recent patients at a single tertiary care center.

Methods: A series of five patients are described, each of whom presented to a single institution as referrals for "large adrenal mass" in the past sixteen months. Their pre-operative diagnosis, radiographic findings, the operative approach and the ...


Prrx1-Crealplfl/Flmice, A Model For Further Investigations Into The Pathophysiological Changes In Hypophosphatemia, Victoria DeMambro, Jennifer Daruszka, Daniel Brooks, Mary Bouxsein, Cliff Rosen 2020 Maine Medical Center

Prrx1-Crealplfl/Flmice, A Model For Further Investigations Into The Pathophysiological Changes In Hypophosphatemia, Victoria Demambro, Jennifer Daruszka, Daniel Brooks, Mary Bouxsein, Cliff Rosen

Costas T. Lambrew Research Retreat 2020

Hypophosphatasia (HPP) is caused by loss of function mutations in the tissuenonspecific alkaline phosphatase (TNSALP) gene (Alpl) which results in rickets, osteomalicia and bone fragility with severe childhood forms resulting in lean body mass. TNSALP is a glycosylphosphatidylinositol (GPI)-anchored phosphatase localized at the plasma membrane which when cleaved can also be found in circulation. In vitro, inhibition of TNSALP leads to a significant decrease in lipid accumulation suggesting TNSALP, an enzyme known for its mineralizing properties, may be pro-adipogenic. TNSALP has been implicated in bone marrow mesenchymal stem cell (BMMSC) lineage determination between osteoblasts and adipocytes through direct interactions ...


A Retrospective Review Of The Safety And Efficacy Of Direct Oral Anticoagulants (Doacs) In Obese Patients Who Underwent Electrical Cardioversion, Matt Cox, Brian Carlone, Jaclynne Gowen, Amber Rollins, Wes Zemrak 2020 Maine Medical Center

A Retrospective Review Of The Safety And Efficacy Of Direct Oral Anticoagulants (Doacs) In Obese Patients Who Underwent Electrical Cardioversion, Matt Cox, Brian Carlone, Jaclynne Gowen, Amber Rollins, Wes Zemrak

Costas T. Lambrew Research Retreat 2020

Purpose: Abnormal atrial rhythms, including atrial fibrillation (AF) and atrial flutter, are the most common cardiac arrhythmias. Patients often undergo direct current cardioversion (DCCV) to restore normal sinus rhythm (NSR). Previous studies demonstrate that anticoagulation during DCCV decreases the risk of stroke from 6.8% to 1%. Additionally, obese patients are at a heightened risk of developing atrial arrhythmias, and previous pharmacokinetic studies suggest that recommended doses of DOACs may not provide therapeutic anticoagulation in these patients. Landmark trials investigating the use of DOACs during DCCV included a small percentage of patients with a body mass index (BMI) > 40 kg ...


Testosterone (T) And Estradiol (E2) Therapy Alone Can Suppress Gonadal Function In Transgender Patients., India I. Pappas, Wendy Y. Craig, Lindsey V. Spratt, Daniel I. Spratt 2020 Maine Medical Center

Testosterone (T) And Estradiol (E2) Therapy Alone Can Suppress Gonadal Function In Transgender Patients., India I. Pappas, Wendy Y. Craig, Lindsey V. Spratt, Daniel I. Spratt

Costas T. Lambrew Research Retreat 2020

Suppression of endogenous gonadal function is an important goal of transgender hormone therapy in both female-to-male (FTM) and male-to-female (MTF) patients. Current recommendations include exogenous hormone therapy in the form of testosterone (T) for FTM or estradiol (E2) for MTF, in addition to a GnRH agonist or progestin to effectively suppress endogenous gonadal activity. It has been claimed, however, that routine use of a GnRH agonist is not justified in terms of a cost-benefit analysis and there is no clear evidence that progestins add to the feminization of MTF patients. To determine how often T or E2 therapy alone is ...


Does Your Patient Know If They Have Prediabetes?, Sophia Adams, Christina Holt, Amy Haskins 2020 Maine Medical Center

Does Your Patient Know If They Have Prediabetes?, Sophia Adams, Christina Holt, Amy Haskins

Costas T. Lambrew Research Retreat 2020

BACKGROUND: Prediabetes is common; 1 in 3 people have prediabetes, but 9 out of 10 people with prediabetes do not know that they have it. Among those with prediabetes, 25% will progress to diabetes in 3-5 years. MaineHealth has now implemented Diabetes Prevention Program classes, based on a major multicenter clinical research study that showed structured lifestyle interventions can cut the risk of developing type 2 diabetes in half for pre-diabetic participants. This program is available to all patients, free of charge, but in order for patients to participate, they first need to know if they have prediabetes and be ...


Insulin-Like Growth Factor Binding Protein 2 May Promote Bone Loss After Vertical Sleeve Gastrectomy: A Pilot Study And Preliminary Data, A N. Pletch, B Harris, P T. Le, Clifford Rosen 2020 Maine Medical Center

Insulin-Like Growth Factor Binding Protein 2 May Promote Bone Loss After Vertical Sleeve Gastrectomy: A Pilot Study And Preliminary Data, A N. Pletch, B Harris, P T. Le, Clifford Rosen

Costas T. Lambrew Research Retreat 2020

Vertical Sleeve Gastrectomy (VSG) is a successful treatment for obesity; however, one of the unintended consequences is bone loss. The mechanism behind this side effect is unclear. Insulin-like Growth Factor Binding Protein 2 (IGFBP-2) is necessary for osteoclast proliferation and differentiation. It is one of the most highly expressed proteins in human serum after VSG, and its deletion results in resistance to bone loss in mice. We are interested in determining whether IGFBP2 plays a role in the bone loss observed after VSG. • Pilot study: The main objective of the pilot study is to determine which VSG technique is preferred ...


Documentation Of Obesity On The Problem List And Referral Rates Among Obese Children And Adults, Heidi Walls, Christina Holt, Amy Haskins, William Dexter 2020 Maine Medical Center

Documentation Of Obesity On The Problem List And Referral Rates Among Obese Children And Adults, Heidi Walls, Christina Holt, Amy Haskins, William Dexter

Costas T. Lambrew Research Retreat 2020

Purpose/Background: Obesity is a serious public health concern that is overwhelming primary care doctors. The 15 minute office visit model leaves little time for counseling in regards to nutrition and physical activity, and many providers may not have enough expertise in nutrition and exercise to confidently counsel their patients. Despite the time constraints placed on primary care doctors, there are things that can be done. Studies have shown that simply documenting obesity on the problem list promotes action about obesity. The purpose of this study was to determine the rate of obesity documentation on the problem list and referrals ...


Notch Signaling Regulates Perivascular Adipose Tissue (Pvat) Function During Diet-Induced Obesity, Chenhao Yang, Joshua M. Boucher, Larisa M. Ryzhova, Lucy Liaw 2020 Maine Medical Center

Notch Signaling Regulates Perivascular Adipose Tissue (Pvat) Function During Diet-Induced Obesity, Chenhao Yang, Joshua M. Boucher, Larisa M. Ryzhova, Lucy Liaw

Costas T. Lambrew Research Retreat 2020

Background: Obesity is an established risk factor for cardiovascular diseases (CVD) and possibly shares molecular and cellular disease mechanisms as CVD due to their comorbidity. As a component of vasculature, perivascular adipose tissue (PVAT) has been recognized as a critical regulator of vascular function due to its anatomical proximity to the vascular wall. Study in PVAT thus help us understand cross talks between adipose tissue and cardiovascular system to re-evaluate clinical strategies for prevention and treatment of type 2 diabetes and CVD. Recent studies have shown that in addition to development, Notch/Rbp-jk signaling plays a crucial role in regulating ...


Diabetes Education With A Teaching Kitchen Intervention Can Improve Hemoglobin A1c For Type 2 Diabetics Compared To Traditional Diabetes Education, Jill Christensen, Heidi Davis, Charlotte Navarre, Hsin-Fang Li, Kathy Schwab, Richard O'Neil, Justin Ferley 2020 Providence Milwaukie Family Medicine

Diabetes Education With A Teaching Kitchen Intervention Can Improve Hemoglobin A1c For Type 2 Diabetics Compared To Traditional Diabetes Education, Jill Christensen, Heidi Davis, Charlotte Navarre, Hsin-Fang Li, Kathy Schwab, Richard O'Neil, Justin Ferley

Milwaukie Family Medicine

Authors
Jill Christensen MD MPH Providence Milwaukie Hospital
Heidi Davis MSW Providence Milwaukie Hospital
Charlotte Navarre RN Providence Milwaukie Hospital
Hsin-Fang Li PHD Providence Medical Data Research Center
Kathy Schwab MPH RDN Providence Health Education
Richard O’Neil MBA Providence Planning Analyst

Title Diabetes Education with a Teaching Kitchen Intervention Can Improve Hemoglobin A1c for Type 2 Diabetics Compared to Traditional Diabetes Education

Purpose The Providence Milwaukie Community Teaching Kitchen offers health-focused, budget friendly cooking classes for patients. In 2019, we piloted diabetes education classes with an added hands-on culinary session. This study compares the change in hemoglobin A1c for ...


Developmental Regression And Mitochondrial Function In Children With Autism, Kanwaljit Singh, Indrapal N. Singh, Eileen Diggins, Susan Connors, Mohammad A. Karim, David Lee, Andrew W. Zimmerman, Richard E. Frye 2020 University of Massachusetts Medical School

Developmental Regression And Mitochondrial Function In Children With Autism, Kanwaljit Singh, Indrapal N. Singh, Eileen Diggins, Susan Connors, Mohammad A. Karim, David Lee, Andrew W. Zimmerman, Richard E. Frye

Open Access Articles

BACKGROUND: Developmental regression (DR) occurs in about one-third of children with Autism Spectrum Disorder (ASD) yet it is poorly understood. Current evidence suggests that mitochondrial function in not normal in many children with ASD. However, the relationship between mitochondrial function and DR has not been well-studied in ASD.

METHODS: This cross-sectional study of 32 children, 2 to 8 years old with ASD, with (n = 11) and without (n = 12) DR, and non-ASD controls (n = 9) compared mitochondrial respiration and mtDNA damage and copy number between groups and their relation to standardized measures of ASD severity.

RESULTS: Individuals with ASD demonstrated ...


Diabetes Mellitus And Necrotizing Fasciitis – A Deadly Combination; Case Report, Alexandra Toma, Laura Mazilu, Andra Iulia Suceveanu, Florentina Gherghiceanu, Camelia Sandu, Cristina Bica, Liliana Florina Andronache, Ioana Paunica, Lavinia Alexandra Moroianu 2020 DUNĂREA DE JOS UNIVERSITY, FACULTY OF MEDICINE AND PHARMACY, GALAȚI, ROMANIA

Diabetes Mellitus And Necrotizing Fasciitis – A Deadly Combination; Case Report, Alexandra Toma, Laura Mazilu, Andra Iulia Suceveanu, Florentina Gherghiceanu, Camelia Sandu, Cristina Bica, Liliana Florina Andronache, Ioana Paunica, Lavinia Alexandra Moroianu

Journal of Mind and Medical Sciences

Necrotizing fasciitis is a rapidly destructive affliction of soft tissues, with a mortality rate that may reach 73% of the cases. It is characterized by a progressive inflammation and extended necrosis of the subcutaneous tissue and the fascia. Necrotizing fasciitis was first described in 1848, and later in 1920 Meleney identified 20 patients in China in which the infection was presumably triggered by hemolytic streptococcus, linking pathological bacteria to the condition. In 1952, Wilson coined the term necrotizing fasciitis although without successfully identifying the specific pathological bacteria involved. In most cases, both risk and aggravating factors are present, the main ...


Consciousness Level Determination Of Red Meat Consumption Of Pregnant Women, Giresun/Turkey Province, Duygu Balpetek Külcü, Özge Cağcağ Yolcu 2020 DEPARTMENT OF FOOD ENGINEERING, GIRESUN UNIVERSITY, 28200, GIRESUN, TURKEY, DUYGU.BALPETEK@GIRESUN.EDU.TR

Consciousness Level Determination Of Red Meat Consumption Of Pregnant Women, Giresun/Turkey Province, Duygu Balpetek Külcü, Özge Cağcağ Yolcu

Journal of Mind and Medical Sciences

In this study, meat consumption and the nutritional status of pregnant women living in Giresun province of Turkey were investigated. The study was carried out at Giresun University, the Maternity and Pediatrics Training and Research Hospital between February-March 2019. The study group consisted of 218 pregnant women aged 18 to 49 years, who benefited from polyclinic services and agreed to participate in the survey. A questionnaire consisting of 12 questions was used, and the findings were evaluated using SPSS to generate descriptive statistics and t-tests or ANOVAs. The majority of participants stated that red meat is beneficial during pregnancy (71 ...


Microbiota: The Missing Link In The Etiology Of Inflammatory Bowel Disease, Micu Ioan Sergiu, Madalina Elena Manea, Musat Marilena, Dumitru Andrada, Popoiag Roxana Emanuela 2020 EMERGENCY HOSPITAL OF CONSTANTA, DEPARTMENT OF GASTROENTEROLOGY, CONSTANTA, ROMANIA

Microbiota: The Missing Link In The Etiology Of Inflammatory Bowel Disease, Micu Ioan Sergiu, Madalina Elena Manea, Musat Marilena, Dumitru Andrada, Popoiag Roxana Emanuela

Journal of Mind and Medical Sciences

Within its twisted and tight walls, where a hostile and arid environment prevails, the lumen of the digestive tract nests a true microuniverse called the microbiota. The existing relationship between humans and these microorganisms is one in which both benefit, creating a condition called Eubiosis.

The dynamic relationship existing between the microbiota and the human body can be affected at various times, leading to an imbalance that may have important implications on health and generating a condition called Disbiosis.

Recent studies have highlighted possible links between several diseases with incompletely elucidated etiology and disturbances of the microbiota. In this review ...


The Role Of Biotransformation Processes In Mediating Interactions Between Psychotropic Drugs And Natural Products, Nicolae Bacinschi, Ina Pogonea, Lilia Podgurschi, Maria Mihalachi-Anghel, Emil Ștefănescu, Bogdan Socea, Marin Chianu 2020 NICOLAE TESTEMITANU STATE UNIVERSITY OF MEDICINE AND PHARMACY, FACULTY OF MEDICINE, DEPARTMENT OF PHARMACOLOGY AND CLINICAL PHARMACOLOGY, CHIȘINĂU, REPUBLIC OF MOLDOVA.

The Role Of Biotransformation Processes In Mediating Interactions Between Psychotropic Drugs And Natural Products, Nicolae Bacinschi, Ina Pogonea, Lilia Podgurschi, Maria Mihalachi-Anghel, Emil Ștefănescu, Bogdan Socea, Marin Chianu

Journal of Mind and Medical Sciences

Many patients are not aware that natural products such as fruit juices or plant infusions can cause significant interactions with several drugs, some of which can be dangerous, especially when the medical treatment is for neurological or psychiatric disorders. Among the most predisposed for interacting with drugs are citric juices, particularly grapefruit and plant infusions, especially St John`s wort (Hypericum perforatum). Understanding the mechanism and the frequency of this type of interaction helps to avoid it. The goal of this research was to identify and summarize the most relevant reports on interactions between psychotropic drugs and natural beverages, in ...


Anorexia Nervosa And Reproduction: Connecting Brain To Gonads, Mihaela Poterasu, David L. Rowland, Corina Ciobanu, Simona Fica 2020 CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY, BUCHAREST, ROMANIA

Anorexia Nervosa And Reproduction: Connecting Brain To Gonads, Mihaela Poterasu, David L. Rowland, Corina Ciobanu, Simona Fica

Journal of Mind and Medical Sciences

Anorexia nervosa (AN) is a psychiatric disorder that predominantly affects young women and is characterized by low caloric intake and a major dissatisfaction with one’s body image. It is often overlooked and, while patients and family seek medical help, emaciation and nutritional misbalances may become extreme and potentially life threatening. Among the many somatic complications, an accumulation of early endocrine adaptations occurs, leading to functional amenorrhea and impaired reproduction as a result of dysfunction of the hypothalamic-pituitary-ovarian axis. Even though these conditions are reversible, long-term consequences may affect the fertility of women with AN and can lead to maternal ...


Management Of Type 1 Diabetes: A Family Affair, Emily Grubbs 2020 Mississippi State University

Management Of Type 1 Diabetes: A Family Affair, Emily Grubbs

Southeastern Council on Family Relations Conference

People who live with Type 1 diabetes (T1D) have to carefully self-administer insulin to keep blood glucose levels in a safe healthy range – a complex and demanding task (WHO, 2016). Social support has been found to alleviate diabetes-stress and increase management behaviors (Mackey et al., 2016). Social support from family members is especially advantageous, however currently no single family-based intervention has been established to show reliable improvements in T1D outcomes (Rosland et al., 2010). A review of the literature reveals that social support promoting autonomy is associated with the best T1D outcomes; social support that undermines autonomy is associated with ...


A Case Series Of Hyponatremia And Management In Hospitalized Patients, Jake N. Cho MD, Rebecca Ong MD, Izuchukwu Nwakoby MD 2020 HCA Healthcare

A Case Series Of Hyponatremia And Management In Hospitalized Patients, Jake N. Cho Md, Rebecca Ong Md, Izuchukwu Nwakoby Md

Nephrology

No abstract provided.


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