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Endocrinology, Diabetes, and Metabolism Commons

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672 full-text articles. Page 1 of 26.

Preventing And Treating Type 2 Diabetes Through A Physically Active Lifestyle, Raymond W. Leung, Jim Kamla, Man-Cheong Lee, Jennifer Y. Mak 2016 Marshall University

Preventing And Treating Type 2 Diabetes Through A Physically Active Lifestyle, Raymond W. Leung, Jim Kamla, Man-Cheong Lee, Jennifer Y. Mak

Jennifer Y Mak

By the late 1960s, the increasing number of type 2 diabetic cases in children and adolescents rapidly presented a signifi cant public health issue recognized by the American Diabetes Association (2000). Since then, the prevalence of pediatric type 2 diabetes appears to be on the rise not only in the United States but all around the world (Gungor et al., 2005). In the United States, an increase from fewer than four percent to more than 50 percent of new cases of type 2 diabetes in the pediatric population was reported between the years of 1982 and 1998 (American Diabetes Association ...


Type I Diabetes In Children And Vitamin D, Ashley B. Litchfield, Rebecca M. Hayes, Franklin D. Shuler MD, PhD, Susan L. Flesher MD 2016 Marshall University

Type I Diabetes In Children And Vitamin D, Ashley B. Litchfield, Rebecca M. Hayes, Franklin D. Shuler Md, Phd, Susan L. Flesher Md

Susan L Flesher, MD

Vitamin D deficiency is associated with multiple childhood diseases including type 1 diabetes mellitus (T1DM). T1DM in children is becoming more prevalent, with a 23% increase nationally from 2001 to 2009. Similarly, West Virginia has had an 8.1% increase in children with type 1Diabetes from 2008/2009 to 2010/2011. This article highlights the association between vitamin D and type 1 diabetes and discusses vitamin D’s potential role in the reduction and management of T1DM in children.


Impact Of The Heart Watch Program On Patients At Risk Of Developing Metabolic Syndrome, Prediabetes Or Cardiovascular Disease, Jennifer T. Fink, Kathryn K. Havens, Julia A. Schumacher, Renee E. Walker, George L. Morris III, David A. Nelson, Maharaj Singh, Ron A. Cisler 2016 University of Wisconsin-Milwaukee

Impact Of The Heart Watch Program On Patients At Risk Of Developing Metabolic Syndrome, Prediabetes Or Cardiovascular Disease, Jennifer T. Fink, Kathryn K. Havens, Julia A. Schumacher, Renee E. Walker, George L. Morris Iii, David A. Nelson, Maharaj Singh, Ron A. Cisler

Maharaj Singh

Purpose

Metabolic syndrome is a set of metabolic risk factors associated with increased risk of developing cardiovascular disease and type 2 diabetes mellitus. We retrospectively evaluated the effectiveness of a lifestyle modification program (Heart WATCH) geared toward reducing development of chronic disease in women deemed at risk for metabolic syndrome, prediabetes and/or cardiovascular disease.

Methods

Our institution’s Heart WATCH program consists of screening sessions with a multidisciplinary team (physician/nurse, nutritionist and psychologist), a minimum of three visits with a nurse practitioner and weekly follow-up phone calls for a 14-week period. Sociodemographic variables were obtained at initial visit ...


An N Of One: My Review Of Management Of Type 1 Diabetes, Myself As Patient, Jarred Daugherty 2016 Butler University

An N Of One: My Review Of Management Of Type 1 Diabetes, Myself As Patient, Jarred Daugherty

BU Well

As technology has advanced, so has the management of diabetes. Insulin, the essential medication for type 1 diabetes, is marketed in an array of formulations and devices. Continuous glucose monitors (CGM) can be inserted to measure blood glucose every 5 minutes. The rise of social media has given diabetics online support groups, where they can share their story and learn from others overcoming similar challenges. So, how well do the current diabetes management strategies work? My name Is Jarred and I’m a type 1 diabetic. I have tried many of these products and this article is a review of ...


Screening Diabetic And Hypertensive Patients For Ocular Pathology Using Telemedicine Technology In Rural West Virginia: A Retrospective Chart Review, Rezwan Ahmed MD, Stephen M. Petrany, Russell Fry II, Michael Krasnow DO, PhD 2016 Marshall University

Screening Diabetic And Hypertensive Patients For Ocular Pathology Using Telemedicine Technology In Rural West Virginia: A Retrospective Chart Review, Rezwan Ahmed Md, Stephen M. Petrany, Russell Fry Ii, Michael Krasnow Do, Phd

Russell L. Fry, II

Abstract: Purpose: There is a disparity between the number of people who need healthcare and availability of medical services in rural areas. This paper describes the experience of using telemedicine technologies for ophthalmologic evaluation in diabetic and hypertensive patients presenting to a community health center in rural West Virginia.

Methods: A registered nurse at a community health center in McDowell County, WV was trained to use a retinal camera to capture high-resolution digital images of the retina. Patients with diabetes or hypertension were screened during their routine primary care visits. Retinal photos were transmitted to an ophthalmologist for review and ...


Screening Diabetic And Hypertensive Patients For Ocular Pathology Using Telemedicine Technology In Rural West Virginia: A Retrospective Chart Review, Rezwan Ahmed MD, Stephen M. Petrany, Russell Fry II, Michael Krasnow DO, PhD 2016 Marshall University

Screening Diabetic And Hypertensive Patients For Ocular Pathology Using Telemedicine Technology In Rural West Virginia: A Retrospective Chart Review, Rezwan Ahmed Md, Stephen M. Petrany, Russell Fry Ii, Michael Krasnow Do, Phd

Stephen M. Petrany MD

Abstract: Purpose: There is a disparity between the number of people who need healthcare and availability of medical services in rural areas. This paper describes the experience of using telemedicine technologies for ophthalmologic evaluation in diabetic and hypertensive patients presenting to a community health center in rural West Virginia.

Methods: A registered nurse at a community health center in McDowell County, WV was trained to use a retinal camera to capture high-resolution digital images of the retina. Patients with diabetes or hypertension were screened during their routine primary care visits. Retinal photos were transmitted to an ophthalmologist for review and ...


The Role Of 5-Alpha Reductase 3 In Steroid Metabolism, zahi mitri 2016 The University of Texas Graduate School of Biomedical Sciences at Houston

The Role Of 5-Alpha Reductase 3 In Steroid Metabolism, Zahi Mitri

UT GSBS Dissertations and Theses (Open Access)

Background

The growth and development of prostate cancer is largely driven by androgen mediated signaling. The 5-alpha reductase family of enzymes plays an essential role in the conversion of testosterone to the more potent androgen, 5-alpha dihydrotestosterone (DHT), which is capable of binding the androgen receptor to activate gene targets and downstream signaling. This study aimed to evaluate the role of 5-alpha reductase 3 (SRD5A3), a novel member of the 5-alpha reductase family, in steroid metabolism and prostate carcinogenesis.

Materials and Methods

HEK293 cells were transfected with the SRD5A3 human cDNA ORF Clone from OriGene. Steroid substrates (testosterone, progesterone, androstenedione ...


Association Between First Trimester Pregnancy Associated Plasma Protein–A (Papp-A) And Gestational Diabetes Mellitus Development, Aylin Sert, Katherine Leung, Molly E. Waring, Raziel Rojas-Rodriguez, Silvia Corvera, Tiffany A. Moore Simas 2016 University of Massachusetts Medical School

Association Between First Trimester Pregnancy Associated Plasma Protein–A (Papp-A) And Gestational Diabetes Mellitus Development, Aylin Sert, Katherine Leung, Molly E. Waring, Raziel Rojas-Rodriguez, Silvia Corvera, Tiffany A. Moore Simas

Senior Scholars Program

Background: Gestational diabetes (GDM) is a common pregnancy complication with significant cardiometabolic consequences for mothers and offspring. Previous research from our group suggests that adipose tissue IGFBP-5 and its unique metalloprotease PAPP-A (Pregnancy Associated Plasma Protein-A) may play mechanistic roles in GDM development by regulating functional IGF-1 levels and lipid storage and metabolism.

Aim: To examine the relationship between circulating PAPP-A levels and GDM development. We hypothesized that high first trimester PAPP-A levels would be associated with decreased GDM risk.

Methods: A retrospective cohort of women delivering singleton gestations at UMass Memorial Healthcare (2009, 2010, 2014 ...


Is Androgen Excess Masked In Alopecia Areata Patients: A Retrospective Data Analysis Of 1,587 Patients, G. Cheyana Ranasinghe, Melissa Piliang, Wilma Bergfeld 2016 George Washington University

Is Androgen Excess Masked In Alopecia Areata Patients: A Retrospective Data Analysis Of 1,587 Patients, G. Cheyana Ranasinghe, Melissa Piliang, Wilma Bergfeld

GW Research Days 2016 - Present

Studies on the pathophysiology and comorbidities associated with alopecia areata (AA) are limited. The purpose of this study was to determine the prevalence of androgen excess in AA and its subtypes, in relation to demographics and comorbidities. Medical records of 1,587 Patchy AA, AT, AU, and ophiasis patients seen in the Department of Dermatology at the Cleveland Clinic Foundation in Ohio between 2005 and 2015 were reviewed. Out of this cohort, 226 patients met the inclusion criteria. There is evidence that patients with AA had significantly greater prevalence of polycystic ovary syndrome (PCOS) than the general population (p<0.001). Androgen excess was identified in 42.5% (n=96) of the 226 patients with AA or any subtype (p<0.001). The androgen excess group was significantly more likely to present with irregular menses, hirsutism, adult acne, PCOS, and/or ovarian cysts (p<0.001). This study was limited by being retrospective. Our study demonstrated that AA is associated with androgen excess.


Disease-Management In Family Medicine Clinics Through The Addition Of A Health Coach: A Pilot Study, Crystal Cichon, Jessica Kram, Tiffany Mullen, Pamela Voelkers, Kristin Magliocco, Kiley Bernhard, Dennis Baumgardner 2016 Department of Family Medicine, Aurora Health Care

Disease-Management In Family Medicine Clinics Through The Addition Of A Health Coach: A Pilot Study, Crystal Cichon, Jessica Kram, Tiffany Mullen, Pamela Voelkers, Kristin Magliocco, Kiley Bernhard, Dennis Baumgardner

Dennis Baumgardner

Background: In the United States, more than 80% of health care spending is focused on the management of chronic illnesses such as hypertension, diabetes and hyperlipidemia. Controlling these chronic diseases can lead to better health outcomes and decrease the number of preventable deaths. Patient self-management has shown to improve clinical outcomes. In a primary care setting, a multidisciplinary approach can more effectively educate patients on improving their health. Purpose: To assess the impact of a health coach in a primary care setting as it relates to clinical outcomes. Methods: Patients from two Aurora family medicine clinics were referred to a ...


Impact Of Comorbidity Dyads On Heart Failure Treatment In Older Persons, Jerry Gurwitz, Alan Go, Sue Sung, Grace Tabada, Robert Goldberg, David Magid, David Smith, David McManus, Jane Saczynski, Bruce Barton 2016 Meyers Primary Care Institute

Impact Of Comorbidity Dyads On Heart Failure Treatment In Older Persons, Jerry Gurwitz, Alan Go, Sue Sung, Grace Tabada, Robert Goldberg, David Magid, David Smith, David Mcmanus, Jane Saczynski, Bruce Barton

Jerry H. Gurwitz

Background/Aims: The vast majority of heart failure (HF) patients suffer from multiple noncardiac comorbid conditions that may have important implications for clinical management. We assessed the clinical effectiveness and safety associated with the use of beta-blocker therapy for patients in a HF-chronic lung disease dyad group, and the clinical effectiveness and safety associated with the use of angiotensin-converting enzyme (ACE) inhibitors/angiotensin II receptor blockers (ARBs) for patients in a HF-chronic kidney disease (CKD) dyad group. Methods: We identified over 30,000 HF patients with a documented ejection fraction (EF) from four members of the Cardiovascular Research Network –– Kaiser ...


Impact Of Comorbidity Dyads On Heart Failure Treatment In Older Persons, Jerry Gurwitz, Alan Go, Sue Sung, Grace Tabada, Robert Goldberg, David Magid, David Smith, David McManus, Jane Saczynski, Bruce Barton 2016 Meyers Primary Care Institute

Impact Of Comorbidity Dyads On Heart Failure Treatment In Older Persons, Jerry Gurwitz, Alan Go, Sue Sung, Grace Tabada, Robert Goldberg, David Magid, David Smith, David Mcmanus, Jane Saczynski, Bruce Barton

Jane S. Saczynski

Background/Aims: The vast majority of heart failure (HF) patients suffer from multiple noncardiac comorbid conditions that may have important implications for clinical management. We assessed the clinical effectiveness and safety associated with the use of beta-blocker therapy for patients in a HF-chronic lung disease dyad group, and the clinical effectiveness and safety associated with the use of angiotensin-converting enzyme (ACE) inhibitors/angiotensin II receptor blockers (ARBs) for patients in a HF-chronic kidney disease (CKD) dyad group. Methods: We identified over 30,000 HF patients with a documented ejection fraction (EF) from four members of the Cardiovascular Research Network –– Kaiser ...


The Nondietary Determinants Of Vitamin D Status In Pediatric Inflammatory Bowel Disease, Lauren Veit, Louise Maranda, Benjamin Nwosu 2016 University of Massachusetts Medical School

The Nondietary Determinants Of Vitamin D Status In Pediatric Inflammatory Bowel Disease, Lauren Veit, Louise Maranda, Benjamin Nwosu

Benjamin U. Nwosu

OBJECTIVES: The aim of this study was to investigate the relationships between 25-hydroxy vitamin D (25[OH]D) and markers of vitamin D status in inflammatory bowel disease (IBD). METHODS: We conducted a retrospective case-control study of 59 pediatric patients with IBD (age 16.4 ± 2.2 y) and 116 controls (age 14.6 ± 4.4 y), to investigate the association between 25(OH)D and albuminemia for protein-losing enteropathy (PLE) and hepatic dysfunction; alanine transaminase (ALT) for hepatic inflammation; erythrocyte sedimentation rate (ESR) for intestinal inflammation; body mass index (BMI) for adiposity; seasons and skin pigmentation for insolation. Vitamin ...


Adiposity Is Associated With Early Reduction In Bone Mass In Pediatric Inflammatory Bowel Disease, Nithya Setty-Shah, Louise Maranda, Benjamin Nwosu 2016 University of Massachusetts Medical School

Adiposity Is Associated With Early Reduction In Bone Mass In Pediatric Inflammatory Bowel Disease, Nithya Setty-Shah, Louise Maranda, Benjamin Nwosu

Benjamin U. Nwosu

Background: The effect of adiposity on bone mass in the early phases of inflammatory bowel disease (IBD) in children and adolescents is unclear.

Aims: To determine the role of adiposity on bone mass in the first 3 years of diagnosis of IBD.

Hypothesis: Increased adiposity will be associated with increased bone mass in both the controls and IBD subjects.

Setting: University tertiary institution.

Methods: Height-adjusted bone mineral density (BMD) z-scores of 25 subjects, age 13.97 ± 2.70y, diagnosed with IBD for < 4 years were compared to 24 controls, age 13.65 ± 2.60y. Overweight was defined as BMI of ≥85th but <95th percentile, and obesity as BMI ≥95thpercentile. Severity of IBD was determined by the ...


Denosumab Use In A Patient With Bisphosphonate-Resistant Humoral Hypercalcemia Of Malignancy, Maali M. Milhem MD, Adeel mahmood MD, John Leidy MD-PhD 2016 Marshall University

Denosumab Use In A Patient With Bisphosphonate-Resistant Humoral Hypercalcemia Of Malignancy, Maali M. Milhem Md, Adeel Mahmood Md, John Leidy Md-Phd

Marshall Journal of Medicine

ABSTRACT

Objective: To describe the use of denosumab as an option for treating bisphosphonate-resistant humoral hypercalcemia of malignancy.

Methods: We present the clinical history and laboratory findings of a patient with a review of related literature.

Results: A 62 year-old male with stage IV laryngeal squamous cell carcinoma and lung metastases had multiple hospital admissions for asymptomatic hypercalcemia. The patient had no known bone metastases. His laboratory data showed a high calcium level, a low level of intact PTH and a high level of PTHrP, which confirmed the diagnosis of humoral hypercalcemia of malignancy. There was atypically an elevated level ...


Impact Of Comorbidity Dyads On Heart Failure Treatment In Older Persons, Jerry Gurwitz, Alan Go, Sue Sung, Grace Tabada, Robert Goldberg, David Magid, David Smith, David McManus, Jane Saczynski, Bruce Barton 2016 Meyers Primary Care Institute

Impact Of Comorbidity Dyads On Heart Failure Treatment In Older Persons, Jerry Gurwitz, Alan Go, Sue Sung, Grace Tabada, Robert Goldberg, David Magid, David Smith, David Mcmanus, Jane Saczynski, Bruce Barton

Robert J. Goldberg

Background/Aims: The vast majority of heart failure (HF) patients suffer from multiple noncardiac comorbid conditions that may have important implications for clinical management. We assessed the clinical effectiveness and safety associated with the use of beta-blocker therapy for patients in a HF-chronic lung disease dyad group, and the clinical effectiveness and safety associated with the use of angiotensin-converting enzyme (ACE) inhibitors/angiotensin II receptor blockers (ARBs) for patients in a HF-chronic kidney disease (CKD) dyad group. Methods: We identified over 30,000 HF patients with a documented ejection fraction (EF) from four members of the Cardiovascular Research Network –– Kaiser ...


A Plan For The Implementation And Evaluation Of Diet Education In Type 2 Diabetes, Soy Ramsumeer 2016 Walden University

A Plan For The Implementation And Evaluation Of Diet Education In Type 2 Diabetes, Soy Ramsumeer

Walden Dissertations and Doctoral Studies

Abstract

Type 2 Diabetes Mellitus (T2DM) is the seventh leading cause of death in the United States with a projected increase of 552 million people worldwide who will be affected with this illness by 2030. The need to address this issue is vital to prevent complications and reduce healthcare spending. The DNP project is aimed at planning and designing a nutritional education program tailored toward specific ethnic groups in order to increase knowledge in making healthy food choices. This project is intended to educate Registered Nurses (RNs) on nutrition so that they can offer dietary knowledge to T2DM patients. Additional ...


Causal Factors Of Cryptorchidism And Endocrine Disurpting Chemicals Such As Prenatal Maternal Cigarette Smoke: A Narrative Review, Andrew R. Morrissey 2016 University of Central Florida

Causal Factors Of Cryptorchidism And Endocrine Disurpting Chemicals Such As Prenatal Maternal Cigarette Smoke: A Narrative Review, Andrew R. Morrissey

Honors in the Major Theses

Cryptorchidism is a male congenital disorder with an unspecified, multifactorial etiology. This review evaluated the strength of select factors in the development of cryptorchidism to better understand its etiology. The strength of relationship between factors and their respective functions during testicular descent was evaluated. Factors evaluated in the causal pathway include the signaling mechanisms Desert Hedgehog (DHH), Insulin-like Hormone 3 (INSL3) and Platelet-Derived Growth Factor (PDGF), as well as sex hormone regulation (androgen: estrogen ratio, aromatase expression). Articles supporting a factor in testicular descent were evaluated and scored. These scores were summed to create the “Step Score” for each step ...


Detection Of Diabetic Foot Ulcers Using Svm Based Classification, Lei Wang, Peder Pedersen, Diane Strong, Bengisu Tulu, Emmanuel Agu, Qian He, Ronald Ignotz, Raymond Dunn, David Harlan, Sherry Pagoto 2015 Worcester Polytechnic Institute

Detection Of Diabetic Foot Ulcers Using Svm Based Classification, Lei Wang, Peder Pedersen, Diane Strong, Bengisu Tulu, Emmanuel Agu, Qian He, Ronald Ignotz, Raymond Dunn, David Harlan, Sherry Pagoto

Emmanuel O. Agu

Diabetic foot ulcers represent a significant health issue, for both patients’ quality of life and healthcare system costs. Currently, wound care is mainly based on visual assessment of wound size, which suffers from lack of accuracy and consistency. Hence, a more quantitative and computer-based method is needed. Supervised machine learning based object recognition is an attractive option, using training sample images with boundaries labeled by experienced clinicians. We use forty sample images collected from the UMASS Wound Clinic by tracking 8 subjects over 6 months with a smartphone camera. To maintain a consistent imaging environment and facilitate the capture process ...


Human Adipose Tissue Expansion In Pregnancy Is Impaired In Gestational Diabetes Mellitus, Raziel Rojas-Rodriguez, Tiffany Moore Simas, Lawrence Lifshitz, Karl Bellve, So-Yun Min, Jacqueline Pires, Katherine Leung, Crina Boeras, Aylin Sert, Jacqueline Draper, Silvia Corvera 2015 University of Massachusetts Medical School

Human Adipose Tissue Expansion In Pregnancy Is Impaired In Gestational Diabetes Mellitus, Raziel Rojas-Rodriguez, Tiffany Moore Simas, Lawrence Lifshitz, Karl Bellve, So-Yun Min, Jacqueline Pires, Katherine Leung, Crina Boeras, Aylin Sert, Jacqueline Draper, Silvia Corvera

Tiffany A. Moore Simas

AIMS/HYPOTHESIS: During pregnancy, adipose tissue (AT) must expand to support the growing fetus and the future nutritional needs of the offspring. Limited expandability of AT is associated with insulin resistance, attributed to ectopic lipid deposition. This study aimed to investigate human AT expandability during pregnancy and its role in the pathogenesis of gestational diabetes mellitus (GDM). METHODS: This cross-sectional study of omental (OM) and subcutaneous (SQ) AT collected at Caesarean delivery included 11 pregnant and three non-pregnant women with normal glucose tolerance (NGT), five with GDM, three with type 2 diabetes mellitus. Adipocyte size, capillary density, collagen content and ...


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