Phytochemicals As Novel Agents For The Induction Of Browning In White Adipose Tissue, 2016 Philadelphia College of Osteopathic Medicine
Phytochemicals As Novel Agents For The Induction Of Browning In White Adipose Tissue, Yusra Azhar, Ashish Parmar, Colette N Miller, Janaiya S Samuels, Srujana Rayalam
PCOM Scholarly Papers
Obesity and its associated metabolic syndrome continue to be a health epidemic in westernized societies and is catching up in the developing world. Despite such increases, little headway has been made to reverse adverse weight gain in the global population. Few medical options exist for the treatment of obesity which points to the necessity for exploration of anti-obesity therapies including pharmaceutical and nutraceutical compounds. Defects in brown adipose tissue, a major energy dissipating organ, has been identified in the obese and is hypothesized to contribute to the overall metabolic deficit observed in obesity. Not surprisingly, considerable attention has been placed ...
Altered Interleukin-10 Signaling In Skeletal Muscle Regulates Obesity-Mediated Inflammation And Insulin Resistance, 2016 University of Massachusetts Medical School
Altered Interleukin-10 Signaling In Skeletal Muscle Regulates Obesity-Mediated Inflammation And Insulin Resistance, Sezin Dagdeviren, Dae Young Jung, Eunjung Lee, Randall H. Friedline, Hye Lim Noh, Jong Hun. Kim, Payal R. Patel, Nicholas Tsitsilianos, Andrew V. Tsitsilianos, Duy A. Tran, George H. Tsougranis, Caitlyn C. Kearns, Cecilia P. Uong, Jung Yeon. Kwon, Werner Muller, Ki Won. Lee, Jason K. Kim
University of Massachusetts Medical School Faculty Publications
Skeletal muscle insulin resistance is a major characteristic of obesity and type 2 diabetes. Although obesity-mediated inflammation is causally associated with insulin resistance, the underlying mechanism is unclear. Here, we examined the effects of chronic obesity in mice with muscle-specific overexpression of interleukin-10 (MIL10). After 16 weeks of a high-fat diet (HFD), MIL10 mice became markedly obese but showed improved insulin action compared to that of wild-type mice, which was largely due to increased glucose metabolism and reduced inflammation in skeletal muscle. Since leptin regulates inflammation, the beneficial effects of interleukin-10 (IL-10) were further examined in leptin-deficient ob/ob mice ...
Analysis Of The Efforts Of Urban And Rural Health Systems To Achieve Accountable Care Organization Target Goals For Dilated Eye Exams In Individuals With Diabetes, Michele Gilliam
Muskie School Capstones
This capstone project was designed to understand and analyze the completion rates for diabetic dilated eye exams within four different health systems participating in the MaineHealth Accountable Care Organizations (ACO). This research is valuable within the current US health care climate as health care providers have sought to evaluate the cost of care in terms of their value to payers. Moreover, many providers have elected to join the ACO in order to demonstrate better outcomes, improve the cost of care and to share programmatic content and tools to standardized care. Within this capstone, system level workflows and processes were evaluated ...
The Interaction Between Growth Hormone And The Thyroid Axis In Hypopituitary Patients: In Vivo And Ex Vivo Studies, 2016 Royal College of Surgeons in Ireland
The Interaction Between Growth Hormone And The Thyroid Axis In Hypopituitary Patients: In Vivo And Ex Vivo Studies, Nigel Glynn
Alterations in the hypothalamo-pituitary-thyroid (HPT) axis have been reported following growth hormone (GH) replacement. The aim of this study was to examine potential mechanisms responsible for GH-induced changes in the HPT axis. Furthermore, we aimed to explore the relationship between changes in the serum concentration of thyroid hormones and peripheral biomarkers of thyroid hormone action, before and after GH replacement.
Twenty men with severe GH deficiency participated in a prospective, observational study of physiological GH replacement. Research measurements were conducted immediately prior to commencing and 3-6 months after GH replacement.
Following GH replacement, the ratio of freeT3:freeT4 in serum ...
The Effects Of Saxagliptin Vs. Gliclazide And Taurine Vs. Placebo On Endothelial Progenitor Cells And Arterial Stiffness In Type 2 Diabetes, 2016 Royal College of Surgeons in Ireland
The Effects Of Saxagliptin Vs. Gliclazide And Taurine Vs. Placebo On Endothelial Progenitor Cells And Arterial Stiffness In Type 2 Diabetes, Wan Aizad Wan Mahmood
Abstract Study 1
Cardiovascular safety of DPP-4 inhibition in participants with Type 2 Diabetes Mellitus: Endothelial Progenitor Cells as an early marker of long-term cardiovascular risk
Endothelial Progenitor Cells (EPCs) play a central role in cardiovascular repair and increasing EPC number is a strong determinant of future cardiovascular risk(1). Interventions, which modify cardiovascular risk, have early effects on EPC number and function (2). Establishing cardiovascular safety of any new anti-diabetic agent typically requires long-term post-marketing trials. DPP-4 inhibitors are a new class of glucose-lowering medication(3). We aimed to evaluate the long-term cardiovascular safety of Saxagliptin (SAX, a DPP-4 ...
Data From: Vitamin D Status In Pediatric Irritable Bowel Syndrome, 2016 University of Massachusetts Medical School
Data From: Vitamin D Status In Pediatric Irritable Bowel Syndrome, Benjamin U. Nwosu, Louise S. Maranda, Ninfa Candela
Pediatric Research Data
This dataset is the primary data source for a manuscript submitted for publication.
Importance: Irritable bowel syndrome (IBS) is associated with significant morbidity in children and adolescents, and the therapeutic efficacy of available treatment options is limited. The role of vitamin D supplementation in pediatric IBS is unclear as the vitamin D status of pediatric patients with IBS is unknown. Equally the relationship of vitamin D status with psychosomatic symptoms in children and adolescents is unclear.
Aim: To characterize the vitamin D status of pediatric patients with IBS using a case-control study design.
Hypothesis: Serum 25-hydroxyvitamin D [25 ...
Lack Of Cross-Reactivity Allergy Following A Switch From Alirocumab To Evolocumab, 2016 Albany College of Pharmacy and Health Sciences
Lack Of Cross-Reactivity Allergy Following A Switch From Alirocumab To Evolocumab, Matthew D. Stryker, Michael Kane, Robert Busch
Excerpts in Pharmacy Research Journal
The proprotein convertase subtilisin/kexin type 9 (PCSK9) gene and gain-of-function mutations were first described in 2003. The gain-of-function mutations observed were associated with low-density lipoprotein-cholesterol (LDL-C) levels in the 400’s, in addition to premature cardiovascular disease. Subsequent loss-of-function experiments conducted in mice demonstrated marked reductions in plasma cholesterol levels in the absence of PCSK9. Physiologically, PCSK9 serves as a chaperone protein and functions to reduce low-density lipoprotein (LDL) receptor recycling; consequently, less LDL-C is removed from circulation and serum lipid concentrations become elevated. Inhibition of PCSK9 prevents LDL receptor degradation and preserves receptor recycling to the hepatocyte surface ...
Understanding Adipocyte Dynamics Through Mathematical Modeling, 2016 University of Utah
Understanding Adipocyte Dynamics Through Mathematical Modeling, Katrina Johnson, Fred Adler
Annual Symposium on Biomathematics and Ecology: Education and Research
No abstract provided.
Evaluating Acceptability, Feasibility And Efficacy Of A Diabetes Care Support Program Facilitated By Cellular-Enabled Glucose Meters: A Dissertation, 2016 University of Massachusetts Medical School
Evaluating Acceptability, Feasibility And Efficacy Of A Diabetes Care Support Program Facilitated By Cellular-Enabled Glucose Meters: A Dissertation, Daniel J. Amante
GSBS Dissertations and Theses
Background. Diabetes requires significant disease management, patient-provider communication, and interaction between patients, family members, caregivers, and care teams. Emerging patient-facing technologies, such as cellular-enabled glucose meters, can facilitate additional care support and improve diabetes self-management. This study evaluated patient acceptability, feasibility, and efficacy of a diabetes care support program facilitated by cellular-enabled glucose meters.
Methods. A two-phase study approach was taken. Get In Touch – Phase 1 (GIT-1) was a 1-month pilot involving patients with type 1 and type 2 diabetes. Get In Touch – Phase 2 (GIT-2) was a 12-month randomized controlled crossover trial involving patients with poorly-controlled type 2 diabetes ...
A Longitudinal Study Of Peripubertal Serum Organochlorine Concentrations And Semen Parameters In Young Men: The Russian Children's Study, 2016 Harvard T.H. Chan School of Public Health
A Longitudinal Study Of Peripubertal Serum Organochlorine Concentrations And Semen Parameters In Young Men: The Russian Children's Study, Lidia Minguez-Alarcon, Oleg Sergeyev, Jane S. Burns, Paige L. Williams, Mary M. Lee, Susan A. Korrick, Luidmila Smigulina, Boris Revich, Russ Hauser
Pediatric Publications and Presentations
BACKGROUND: Exposures to endocrine disrupting chemicals during critical phases of testicular development may be related to poorer semen parameters. However, few studies have assessed the association between childhood organochlorine (OC) exposure and adult semen parameters.
OBJECTIVE: We examined whether peripubertal serum OC concentrations are associated with semen parameters among young Russian men.
METHODS: From 2003 to 2005, 516 boys were enrolled at age 8-9 years and followed for up to ten years. Serum OCs were measured in the enrollment samples using high-resolution mass spectrometry. At age 18-19 years, 133 young men provided one or two semen samples (256 samples) collected ...
The Effect Of Increased Sleep On The Circadian Rhythm Of Salivary Cortisol Concentrations, 2016 Seton Hall University
The Effect Of Increased Sleep On The Circadian Rhythm Of Salivary Cortisol Concentrations, Mariah Jacqueline Scott
Seton Hall University Dissertations and Theses (ETDs)
Cortisol is a salivary marker for the hypothalamic-pituitary-adrenal axis (HPA) component of the stress response. The activity of the HPA demonstrates a circadian rhythm. It is well known that sleep deprivation increases cortisol concentrations. In this study, we looked at the effect of an increase of one-hour sleep for one month on the circadian rhythm of the HPA.
Eight college subjects (n=8) collected saliva during their normal sleep wake cycle every 4 hours for 24 hours. Saliva collections were repeated after a month of increase of sleep by 1-hour. The subjects also completed demographic forms that asked for age ...
The Postfinasteride Syndrome; An Overview, 2016 Valparaiso University, Department of Psychology
The Postfinasteride Syndrome; An Overview, David L. Rowland, Ion G. Motofei, Florian Popa, Vlad D. Constantin, Adriana Vasilache, Ioana Păunică, Cristian Bălălău, Georgeta P. Păunică, Petrisor Banu, Stana Păunică
Journal of Mind and Medical Sciences
As a 5-α reductase inhibitor, Finasteride has proven effective in ameliorating two conditions documented to be androgen dependent, namely male androgenic alopecia and benign prostatic hyperplasia. Therapeutic results are maintained as long as the drug is administered, with treatment cessation generally leading to the return of symptomatology for each condition. In addition, during the therapeutic phase, several adverse effects have been reported, some of which persist long or indefinitely after treatment cessation, known as “post-finasteride syndrome.”
Herein we present and discuss the most common finasteride side effects, along with a psycho-neuroendocrine rationale that could explain the persistence of many adverse ...
Regulation Of Polycystin-1 Function By Calmodulin Binding, 2016 University of California, Santa Barbara
Regulation Of Polycystin-1 Function By Calmodulin Binding, Nicholas Doerr, Yidi Wang, Kevin R. Kipp, Guangyi Liu, Jesse J. Benza, Vladimir Pletnev, Tengis S. Pavlov, Alexander Staruschenko, Ashraf M. Mohieldin, Maki Takahashi, Surya M. Nauli, Thomas Weimbs
Pharmacy Faculty Articles and Research
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disease that leads to progressive renal cyst growth and loss of renal function, and is caused by mutations in the genes encoding polycystin-1 (PC1) and polycystin-2 (PC2), respectively. The PC1/PC2 complex localizes to primary cilia and can act as a flow-dependent calcium channel in addition to numerous other signaling functions. The exact functions of the polycystins, their regulation and the purpose of the PC1/PC2 channel are still poorly understood. PC1 is an integral membrane protein with a large extracytoplasmic N-terminal domain and a short, ~200 amino acid C-terminal ...
Rediscovery Of Self-Care For Incarcerated Persons With Diabetes, 2016 University of Connecticut - Storrs
Rediscovery Of Self-Care For Incarcerated Persons With Diabetes, Louise Reagan, Deborah Shelton, Elizabeth Anderson
Journal for Evidence-based Practice in Correctional Health
Purpose: To examine self-care for diabetes in the incarcerated population within the framework of the Rediscovery of Self-Care (RSC), a newly developed care model for persons with incarceration experience
Organizing Construct: Diabetes is a chronic illness that requires the development and use complex self-care management skills. The RSC is a strengths-based model promoting the belief that inmate- patients are capable of re-discovering their own strengths for self-care.
Findings: Persons with an incarceration experience have person and environment exposures that reduce their self-care capabilities for diabetes. Using a clinical case management approach, clinicians can assist incarcerated persons with re-entry and re-integration ...
Vitamin D Deficiency In Ambulatory Patients, 2016 Aga Khan University
Vitamin D Deficiency In Ambulatory Patients, Lubna M Zuberi, Aysha Habib, Naeemul Haque, Abdul Jabbar
Aysha Habib Khan
OBJECTIVE: To determine the frequency of subclinical vitamin D deficiency in an ambulatory care setting.
METHODS: This was an observational study which measured 25 vitamin D levels in medical clinic patients. Patients with chronic renal failure, known osteomalacia and rickets were excluded. A total of 119 patients were evaluated. They were divided in three diagnostic categories based on their serum 25 vitamin D levels. Those with levels below 8 ng/ml were categorized to have severe deficiency, levels between 8 - 20 ng/ml as moderate deficiency and levels of 21-35 mg/ml as mild deficiency.
RESULTS: Of 119 patients, 92 ...
Vitamin D Supplementation: Preventing Fractures, 2016 James Madison University
Vitamin D Supplementation: Preventing Fractures, Courtney L. Carn, Michael S. Doherty
Physician Assistant Capstones
Objective: To assess the ability of vitamin D supplementation in preventing musculoskeletal fractures. Methods: Systematic literature review using Google Scholar search terms “vitamin D supplementation” and “preventing hip fractures” from 2006-2015. Only RCTs, meta-analysis, and clinical guidelines were included. Results: Our search resulted in one meta-analysis and two randomized controlled trials. Conclusion: The summation of our investigation into vitamin D deficiency and the presence of musculoskeletal fractures has proven to be relatively inconclusive. The resulting data from our three studies did not provide any definitive proof that improved vitamin D levels correlates with better bone health.
Want To Lose Weight? Commercial Weight Loss Programs Vs. Primary Care, 2016 James Madison University
Want To Lose Weight? Commercial Weight Loss Programs Vs. Primary Care, Jessica Jacobson, Katherine Chui
Physician Assistant Capstones
Context Overweight and obesity rates are on a continuous incline in the United States leading to increased rates of diabetes, cardiovascular disease and death. Much of the healthcare costs are going into treating this disease; therefore, it is vital to find effective weight loss treatments in both the primary care and community settings to reduce the prevalence of overweight and obesity and subsequent healthcare costs.
Objective To assess whether primary care-based therapy or commercial weight loss programs help overweight and obese patients lose 5% of their weight from baseline.
Design, Setting and Participants A systematic review of four randomized control ...
Retrospective Review Of Maternal And Fetal Outcomes Of Indigent Gestational Diabetes Patients Treated With Diet Monotherapy Or Diet And Insulin, 2016 Philadelphia College of Osteopathic Medicine
Retrospective Review Of Maternal And Fetal Outcomes Of Indigent Gestational Diabetes Patients Treated With Diet Monotherapy Or Diet And Insulin, Sara Wilson Reece, Harish S. Parihar, Mark Martinez, Nicole Taylor
Sara Wilson Reece
No abstract provided.
Medication Management In Diverse Populations, 2016 Presbyterian College
Medication Management In Diverse Populations, Sara Wilson Reece, Julie Sease
Sara Wilson Reece
No abstract provided.
Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, 2016 Marshall University, Joan C. Edwards School of Medicine
Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, Md, Thomas Melvin, Brandon Merritt, Charles Bishop, Md, Franklin D. Shuler, Md, Phd
Marshall Journal of Medicine
Vitamin K is known to play an essential role in the coagulation cascade; however, a growing body of research has found that a subtype of this vitamin, vitamin K2 (menaquinone) may have a beneficial effect in osteoporosis, cardiovascular disease, and cancer. This purpose of this article is to provide a comprehensive review of recent literature regarding menaquinone and its role in human health. This review discusses the physiology of menaquinone, its clinical benefits in cardiovascular disease, osteoporosis, and cancer, and how it may interact with certain medications. The authors conclude that menaquinone supplementation has been shown to improve carboxylation ...