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Ultrasonographic Renal Size In Individuals Without Known Renal Disease., Niels-Peter Buchholz, Farhat Abbas, Syed Raziuddin Biyabani, Qaiser Javed, Jamsheer Talati, Masood Afzal, Imtiaz Rizvi 2016 Aga Khan University

Ultrasonographic Renal Size In Individuals Without Known Renal Disease., Niels-Peter Buchholz, Farhat Abbas, Syed Raziuddin Biyabani, Qaiser Javed, Jamsheer Talati, Masood Afzal, Imtiaz Rizvi

Farhat Abbas

Objective: In order to establish some preliminary data of our population, we determined the ultrasonographic kidney dimensions in individuals withoud known renal disease. We assessed whether age, sex, side, body mass index (BMI) and presence or absence of diabetes mellitus and hypertension affect the renal size. Methods: Ultrasonographic kidney measurements were performed on 194 adult patients without known kidney lesions. Measurements included length, width, cortical thickness and estimation of renal size which was obtained by multiplying the first three variables. The effect of age, gender, side, height, weight, BNll, hypertension and diabetes mellitus was statistically analyzed. Results: The mean kidney ...


Understanding The Context Of Balanced Scorecard Implementation: A Hospital-Based Case Study In Pakistan., Fauziah Rabbani, Sabrina NH Lalji, Farhat Abbas, SM Wasim Jafri, Junaid A. Razzak, Naheed Nabi, Firdous Jahan, Agha Ajmal, Max Petzold, Mats Brommels, Goran Tomson 2016 Aga Khan University

Understanding The Context Of Balanced Scorecard Implementation: A Hospital-Based Case Study In Pakistan., Fauziah Rabbani, Sabrina Nh Lalji, Farhat Abbas, Sm Wasim Jafri, Junaid A. Razzak, Naheed Nabi, Firdous Jahan, Agha Ajmal, Max Petzold, Mats Brommels, Goran Tomson

Farhat Abbas

BACKGROUND:

As a response to a changing operating environment, healthcare administrators are implementing modern management tools in their organizations. The balanced scorecard (BSC) is considered a viable tool in high-income countries to improve hospital performance. The BSC has not been applied to hospital settings in low-income countries nor has the context for implementation been examined. This study explored contextual perspectives in relation to BSC implementation in a Pakistani hospital.

METHODS:

Four clinical units of this hospital were involved in the BSC implementation based on their willingness to participate. Implementationincluded sensitization of units towards the BSC, developing specialty specific BSCs and ...


The Prevalence Of Silent Kidney Stones - An Ultrasonographic Screening Study, Buchholz Niels-Peter, Farhat Abbas, R Khan, Jamsheer J Talati, M Afzal, I Rizvi 2016 Aga Khan University

The Prevalence Of Silent Kidney Stones - An Ultrasonographic Screening Study, Buchholz Niels-Peter, Farhat Abbas, R Khan, Jamsheer J Talati, M Afzal, I Rizvi

Farhat Abbas

Objective:

Silent and not yet discovered stones of the upper urinary tract are potentially dangerous, since in due course they may cause infection, obstruction and renal damage. The aim of this study was to determine the prevalence of such silent kidney stones in a representative Pakistani population of Karachi. Subjects and

Methods:

We studied 201 consecutive subjects at our hospital who underwent additional kidney screening whilst undergoing abdominal ultrasound. All these subjects did not have a history or symptoms of urolithiasis.

Results:

We found silent kidney stones in 3% of subjects. All stone bearers were males. Most stones were in ...


Role Of Surgery In Locally Advanced Prostate Cancer, Nazim Syed Muhammad, Farhat Abbas 2016 Aga Khan University

Role Of Surgery In Locally Advanced Prostate Cancer, Nazim Syed Muhammad, Farhat Abbas

Farhat Abbas

A significant proportion of patients present with locally advanced prostate cancer with inherent higher risk of local recurrence and systemic relapse after initial treatment. Recent literature favors combination of radiation therapy and extended hormonal therapy for this subset of patients. The effectiveness of Radical prostatectomy (RP) alone for locally advanced prostate cancer is controversial and is a focus of debate. However, it can decrease the tumor burden and allows the accurate and precise pathological staging with the need for subsequent treatment. Comparison of RP and other treatment modalities is difficult and incorrect because of inherent selection bias. RP as a ...


Surgical Management Of Penile Cancer--Report Of Two Cases., M Amjad Noor, Hammad Ather, M Nasir Sulaiman, Farhat Abbas 2016 Aga Khan University

Surgical Management Of Penile Cancer--Report Of Two Cases., M Amjad Noor, Hammad Ather, M Nasir Sulaiman, Farhat Abbas

Farhat Abbas

Introduction

Penile carcinoma (PC) is a rare tumor, accounting for 0.4-0.6% of all male malignancies. There are remarkable racial and geographic differences in the prevalence of penile cancer. In United States, 1% of all male cancers are penile malignancies, with annual incidence of 1-2 new cases per 100,000 men. In certain areas of South America, Asia and Africa the frequency is as high as 10-20% of all male cancers. Many areas in Asia however, have very low figures; in Taiwan for example it comprised only 0.25% of all male cancers1. Penile carcinoma is most frequent ...


Surgical Management Of Pheochromocytoma In A 13-Week Pregnant Woman., Mazhar Ali Memon, Wajahat Aziz, Farhat Abbas 2016 Aga Khan University

Surgical Management Of Pheochromocytoma In A 13-Week Pregnant Woman., Mazhar Ali Memon, Wajahat Aziz, Farhat Abbas

Farhat Abbas

A 34-year-old 13-week pregnant woman presented with hypertension refractory to medical therapy and on workup was found to have a right adrenal mass. Due to her persistent increased blood pressure she was advised urinary vanillylmandelic acid (VMA) and its level was raised. MRI of the abdomen showed a well-circumcised lesion in the right adrenal of 3.0×2.5 cm suggestive of pheochromocytoma. The patient was started on antihypertensives including α-blockers and β-blockers and planned for right open adrenalectomy. Intraoperatively, blood pressure was raised up to 180/110 mm Hg on slight manipulation of adrenal gland which was controlled with ...


Silencing Of Mbd1 And Mecp2 In Prostate-Cancer-Derived Pc3 Cells Produces Differential Gene Expression Profiles And Cellular Phenotypes., Yaqinuddin Ahmed, Farhat Abbas, Syed S. Naqvi, Mohammad U. Bashir, Romena Qazi, Sohail A. Qureshi 2016 Aga Khan University

Silencing Of Mbd1 And Mecp2 In Prostate-Cancer-Derived Pc3 Cells Produces Differential Gene Expression Profiles And Cellular Phenotypes., Yaqinuddin Ahmed, Farhat Abbas, Syed S. Naqvi, Mohammad U. Bashir, Romena Qazi, Sohail A. Qureshi

Farhat Abbas

Alterations in genomic CpG methylation patterns have been found to be associated with cell transformation and neoplasia. Although it is recognized that methylation of CpG residues negatively regulates gene expression, how the various MBPs (methyl-binding proteins) contribute to this process remains elusive. To determine whether the two well characterized proteins MeCP2 (methyl-CpG-binding protein 2) and MBD1 (methyl-CpG-binding domain 1) have distinct or redundant functions, we employed RNAi (RNA interference) to silence their expression in the prostate cancer-derived PC3cell line, and subsequently compared cell growth, invasion and migration properties of these cell lines in addition to their respective mRNA-expressionprofiles. Cells devoid ...


Promoter Hypermethylation Of Tumor Suppressor Genes Correlates With Tumor Grade And Invasiveness In Patients With Urothelial Bladder Cancer., Shumaila M. Bilgrami, Sohail A. Qureshi, Shahid Pervez, Farhat Abbas 2016 Aga Khan University

Promoter Hypermethylation Of Tumor Suppressor Genes Correlates With Tumor Grade And Invasiveness In Patients With Urothelial Bladder Cancer., Shumaila M. Bilgrami, Sohail A. Qureshi, Shahid Pervez, Farhat Abbas

Farhat Abbas

Purpose: To investigate the promoter methylation status at selected loci which encode for key proteins involved in apoptosis, DNA repair, cell cycle control and progression in urothelial cell carcinoma of bladder and compare the findings from tissue samples with that of plasma. Methods: Total genomic DNA was isolated from 43 non-muscle invasive (low grade) and 33 muscle invasive (high grade) urothelial bladder cancer samples along with 10 control cases of normal bladder mucosa. Promoter methylation status was investigated for RASSF1A, APC, MGMT, CDKN2A and CDKN2B genes using real-time methylation-specific PCR with SYBR® green. Plasma samples from 16 patients with muscle ...


Renal Arteriovenous Malformation: An Unusual Cause Of Recurrent Haematuria., Mazhar Ali, Wajahat Aziz, Farhat Abbas 2016 Aga Khan University

Renal Arteriovenous Malformation: An Unusual Cause Of Recurrent Haematuria., Mazhar Ali, Wajahat Aziz, Farhat Abbas

Farhat Abbas

Summary

A 54-year-old woman presented with gross painless haematuria. Initial workup showed no abnormality except mild hydronephrosis on CT scan. Cystoscopy and retrograde pyelography did not find any gross lesion and her urine cytology was also negative. She had recurrent haematuria so her CT was reviewed with the radiologist with clinical suspicion of arteriovenous malformation (AVM) which was suggested by relatively increased contrast density in the hemiazygous vein and renal vein in the arterial phase. She underwent angioembiolisation of left renal AVM after which her haematuria settled.


Post-Chemotherapy Residual Mass In Stage Iic Seminomatous Testicular Tumor, N A. Ahmad, S R. Biyabani, Farhat Abbas 2016 Aga Khan University

Post-Chemotherapy Residual Mass In Stage Iic Seminomatous Testicular Tumor, N A. Ahmad, S R. Biyabani, Farhat Abbas

Farhat Abbas

Introduction

The management of patients with residual masses following chemotherapy for advanced seminoma remains a difficult problem with no clear guidelines. While most patients with advanced seminoma achieve a complete or partial response with cisplatin based chemotherapy1, a significant number will reveal a residual mass on follow up CT scan or MR imaging2,3. Management options for post chemotherapy residual mass in a case of seminoma include close observation, radiation therapy and excisional surgery. While 80 to 85% of residual masses represent either fibrosis or necrotic tissue needing no further therapy, 10 to 15% may contain viable tumor ...


Hiv-1 Subtype A Gag Variability And Epitope Evolution., Syed Hani Abidi, Marcia L. Kalish, Farhat Abbas, Sarah Rowland-Jones, Syed Ali 2016 Aga Khan University

Hiv-1 Subtype A Gag Variability And Epitope Evolution., Syed Hani Abidi, Marcia L. Kalish, Farhat Abbas, Sarah Rowland-Jones, Syed Ali

Farhat Abbas

OBJECTIVE:

The aim of this study was to examine the course of time-dependent evolution of HIV-1 subtype A on a global level, especially with respect to the dynamics of immunogenic HIV gag epitopes.

METHODS:

We used a total of 1,893 HIV-1 subtype A gag sequences representing a timeline from 1985 through 2010, and 19 different countries in Africa, Europe and Asia. The phylogenetic relationship of subtype A gag and its epidemic dynamics was analysed through a Maximum Likelihood tree and Bayesian Skyline plot, genomic variability was measured in terms of G → A substitutions and Shannon entropy, and the time-dependent ...


Mediastinal Parathyroid Adenoma Causing Primary Hyperparathyroidism., Farhat Abbas, Syed Raziuddin Biyabani, Amanullah Memon, Jamsheer Talati 2016 Aga Khan University

Mediastinal Parathyroid Adenoma Causing Primary Hyperparathyroidism., Farhat Abbas, Syed Raziuddin Biyabani, Amanullah Memon, Jamsheer Talati

Farhat Abbas

Abstract
An ectopically placed parathyroid adenoma in the anterior mediastinum is a rare cause of persistent or recurrent primary hyperparathyroidism (PHPT) and is recognized as an important cause of failed primary neck exploration. We encountered 3 such cases amongst 70 surgically treated patients with PHPT (4.3%) over a 20-year period. In 2 cases, the offending adenoma could be removed at first exploration whereas in the 3rd case, it was successfully removed with mediastinal exploration after 2 failed neck explorations. In established cases of PHPT with equivocal preoperative localization studies or negative neck explorations, an ectopically placed parathyroid adenoma should ...


Early Surgical Results With Intent To Treat By Radical Retropubic Prostatectomy For Clinically Localized Prostate Cancer., Farhat Abbas, K Siddiqui, S R. Biyabani, Jamsheer Talati, S H. Hassan 2016 Aga Khan University

Early Surgical Results With Intent To Treat By Radical Retropubic Prostatectomy For Clinically Localized Prostate Cancer., Farhat Abbas, K Siddiqui, S R. Biyabani, Jamsheer Talati, S H. Hassan

Farhat Abbas

AIMS:

To evaluate the early cancer control rates, morbidity and mortality in men undergoing radical retropubic prostatectomy (RRP) for clinicallylocalized adenocarcinoma prostate.

METHODS:

Patient's characteristics, operative data, progressive-free survival rates, morbidity and mortality were analyzed for 23 men with clinical T1-2 prostate cancer who underwent surgery with an intent to treat by RRP between December 1997 to July 2001.

RESULTS:

Patient's mean age was 63 +/- 6.2 years (range 51 to 76 years) with American Society of Anesthesiology (ASA) status I in 4%, II in 65% and III in 31%. Two third of the patients had lower urinary ...


Functional And Clinical Outcome Of Ileal (Studer) Neo-Bladder Reconstruction: Single Centre Experience From Pakistan., Syed M. Nazim, M Hammad Ather, Farhat Abbas 2016 Aga Khan University

Functional And Clinical Outcome Of Ileal (Studer) Neo-Bladder Reconstruction: Single Centre Experience From Pakistan., Syed M. Nazim, M Hammad Ather, Farhat Abbas

Farhat Abbas

OBJECTIVE:

To determine the medium and long-term outcome of orthotopic continent urinary diversion with ileal (Studer) neo-bladder following radical cystectomy.

STUDY DESIGN:

Case series.

PLACE AND DURATION OF STUDY:

Department of Surgery, The Aga Khan University Hospital, Karachi, from January 1998 to September 2010.

METHODOLOGY:

Thirty eight patients underwent radical cystectomy for invasive bladder tumor with ileal neo-bladder (Studer type) reconstruction. Peri-operative and late complications, functional outcome of neo-bladder, urinary continence, metabolic and upper urinary tract status and overall survival were evaluated in all patients.

RESULTS:

A total of 29 patients (23 males and 6 females) with mean age of ...


Down-Regulation Of Dnmt3b In Pc3 Cells Effects Locus-Specific Dna Methylation, And Represses Cellular Growth And Migration., Ahmed Yaqinuddin, Sohail A. Qureshi, Romena Qazi, Farhat Abbas 2016 Aga Khan University

Down-Regulation Of Dnmt3b In Pc3 Cells Effects Locus-Specific Dna Methylation, And Represses Cellular Growth And Migration., Ahmed Yaqinuddin, Sohail A. Qureshi, Romena Qazi, Farhat Abbas

Farhat Abbas

BACKGROUND:

Aberrations in DNA methylation patterns promote changes in gene expression patterns and are invariably associated with neoplasia. DNA methylation is carried out and maintained by several DNA methyltransferases (DNMTs) among which DNMT1 functions as a maintenance methylase while DNMT3a and 3b serve as de novo enzymes. Although DNMT3b has been shown to preferentially target the methylationof DNA sequences residing in pericentric heterochromatin whether it is involved in gene specific methylation remains an open question. To address this issue, we have silenced the expression of DNMT3b in the prostate-derived PC3 cells through RNA interference and subsequently studied the accompanied cellular ...


Correlation Of Three Immunohistochemically Detected Markers Of Neuroendocrine Differentiation With Clinical Predictors Of Disease Progression In Prostate Cancer., M Hammad Ather, Farhat Abbas, Nuzhat Fauqui, Mohammad Israr, Shahid Pervez 2016 Aga Khan University

Correlation Of Three Immunohistochemically Detected Markers Of Neuroendocrine Differentiation With Clinical Predictors Of Disease Progression In Prostate Cancer., M Hammad Ather, Farhat Abbas, Nuzhat Fauqui, Mohammad Israr, Shahid Pervez

Farhat Abbas

Background: The importance of immuno-histological detection of neuroendocrine differentiation in prostatic adenocarcinoma with respect to disease at presentation and Gleason grade is gaining acceptance. There is limited literature on the relative significance of three commonly used markers of NE differentiation i.e. Chromogranin A (CgA), Neuron specific enolase (NSE) and Synaptophysin (Syn). In the current work we have assessed the correlation of immuno-histological detection of neuroendocrine differentiation in prostatic adenocarcinoma with respect to disease at presentation and Gleason grade and to determine the relative value of various markers. Materials and methods: Consecutive samples of malignant prostatic specimens (Transurethral resection of ...


Burden Of Communicable Disease Among The Native And Repatriating Afghans, Syed Hani Abidi, Farwa Ali, Farida Shah, Farhat Abbas 2016 Aga Khan University

Burden Of Communicable Disease Among The Native And Repatriating Afghans, Syed Hani Abidi, Farwa Ali, Farida Shah, Farhat Abbas

Farhat Abbas

No abstract provided.


An Unusual Combination Of Extra-Adrenal Pheochromocytoma And Arteriovenous Malformation Of The Ureter In A Young Adult., Ali Khawaja, Wajahat Aziz, Syed Muhammad Nazim, Farhat Abbas 2016 Aga Khan University

An Unusual Combination Of Extra-Adrenal Pheochromocytoma And Arteriovenous Malformation Of The Ureter In A Young Adult., Ali Khawaja, Wajahat Aziz, Syed Muhammad Nazim, Farhat Abbas

Farhat Abbas

We present a case of a 24-year-old gentleman who presented with painless pan haematuria for 2 weeks. During the workup, he was diagnosed to have a retrocaval mass after a CT scan while cystoscopy revealed a polypoidal pulsating lesion in the left ureter. After surgical manipulation of the retrocaval mass, the blood pressure of the patient raised to 260/130 mm Hg. It was completely resected and diagnosed as extra-adrenalpheochromocytoma (paraganglioma) after histopathology. The lesion in the ureter was completely excised and fulgurated and diagnosed as anarteriovenous malformation. To the best of our knowledge, this is the first patient to ...


First-Case Operating Room Delays: Patterns Across Urban Hospitals Of A Single Health Care System, Callie M. Cox Bauer, Danielle M. Greer, Kiley B. Vander Wyst, Scott A. Kamelle 2016 United States Air Force San Antonio Military Medical Center

First-Case Operating Room Delays: Patterns Across Urban Hospitals Of A Single Health Care System, Callie M. Cox Bauer, Danielle M. Greer, Kiley B. Vander Wyst, Scott A. Kamelle

Journal of Patient-Centered Research and Reviews

Purpose

Operating room delays decrease health care system efficiency and increase costs. To improve operating room efficiency in our system, we retrospectively investigated delay frequencies, causes and costs.

Methods

We studied all first-of-the-day nonemergent surgical cases performed at three high-volume urban hospitals of a large health system from July 2012 to November 2013. Times for patient flow from arrival to procedure start and documented reasons for delay were obtained from electronic medical records. Delay was defined as patient placement in the operating room later than scheduled surgery time. Effects of patient characteristics, late patient arrival to the hospital, number of ...


Fate Of Abstracts Presented At The 2007-2009 Americas Hepato-Pancreato-Biliary Association Meetings, Joel B. Durinka MD, Tyler Wenzel, Christopher Ortiz, Lynn Choi, Jorge Ortiz 2016 University of Buffalo

Fate Of Abstracts Presented At The 2007-2009 Americas Hepato-Pancreato-Biliary Association Meetings, Joel B. Durinka Md, Tyler Wenzel, Christopher Ortiz, Lynn Choi, Jorge Ortiz

Translation: The University of Toledo Journal of Medical Sciences

Background: Information presented in society meetings has not been completely vetted through a formal review process. It is not entirely clear if it is accurate or will ever be published in peer reviewed journals.

Materials and Methods: A Pubmed-Medline search was performed for all abstracts presented at the AHBPA from 2007-2009 Different variables including country of origin, study center, and academic institution were examined to determine if any could predict eventual publication.

Results: 33.4% of all abstracts presented materialized into full text manuscripts. The average time to publication was 14 months. In total, 46% of abstracts were published in ...


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