Pediatrics Commons^™

Long-Term Influence Of Normal Variation In Neonatal Characteristics On Human Brain Development, Kristine Beate Walhovd, Anders M. Fjell, Timothy T. Brown, Joshua M. Kuperman, Yoonho Chung, Donald J. Hagler Jr., J. Cooper Roddey, Matthew Erhart, Connor Mccabe, Natacha Akshoomoff, David G. Amaral, Cinnamon S. Bloss, Ondrej Libiger, Nicholas J. Schork, Burcu F. Darst, B. J. Casey, Linda Chang, Thomas M. Ernst, Jean A. Frazier, Jeffrey R. Gruen, Walter E. Kaufmann, Sarah S. Murray, Peter Van Zijl, Stewart Mostofsky, Anders Dale, Pediatric Imaging, Neurocognition, And Genetics Study

Psychiatry Publications and Presentations

It is now recognized that a number of cognitive, behavioral, and mental health outcomes across the lifespan can be traced to fetal development. Although the direct mediation is unknown, the substantial variance in fetal growth, most commonly indexed by birth weight, may affect lifespan brain development. We investigated effects of normal variance in birth weight on MRI-derived measures of brain development in 628 healthy children, adolescents, and young adults in the large-scale multicenter Pediatric Imaging, Neurocognition, and Genetics study. This heterogeneous sample was recruited through geographically dispersed sites in the United States. The influence of birth weight on cortical thickness ...

Double Diabetes: The Search For A Treatment Paradigm In Children And Adolescents, Benjamin U. Nwosu

Endocrinology/Diabetes

Discusses double diabetes -- the coexistence of features of both type 1 and type 2 diabetes in the same individual -- with a comprehensive discussion of the various aspects of this disorder and a focus on the search for a treatment paradigm in children and adolescents.

Escherichia Coli Isolates That Carry Vat, Fyua, Chua, And Yfcv Efficiently Colonize The Urinary Tract, Rachel R. Spurbeck, Paul C. Dinh Jr., Seth T. Walk, Ann E. Stapleton, Thomas M. Hooton, Lisa K. Nolan, Kwang Sik Kim, James R. Johnson, Harry L. T. Mobley

Veterinary Microbiology and Preventive Medicine Publications and Papers

Extraintestinal Escherichia coli (ExPEC), a heterogeneous group of pathogens, encompasses avian, neonatal meningitis, and uropathogenic E. coli strains. While several virulence factors are associated with ExPEC, there is no core set of virulence factors that can be used to definitively differentiate these pathotypes. Here we describe a multiplex of four virulence factor-encoding genes, yfcV, vat,fyuA, and chuA, highly associated with uropathogenic E. coli strains that can distinguish three groups of E. coli: diarrheagenic and animal-associated E. colistrains, human commensal and avian pathogenic E. coli strains, and uropathogenic and neonatal meningitis E. coli strains. Furthermore, human intestinal isolates that encode ...

When Informationists Get Involved: The Chica-Gis Project, Elizabeth C. Whipple, Jere D. Odell, Rick K. Ralston, Gilbert C. Liu

Journal of eScience Librarianship

Child Health Improvement through Computer Automation (CHICA) is a computer decision support system (CDSS) that interfaces with existing electronic medical record systems (EMRS) and delivers "just in time" patient-relevant guidelines to physicians during the clinical encounter and accurately captures structured data from all who interact with the system. “Delivering Geospatial Intelligence to Health Care Professionals (CHICA-GIS)” (1R01LM010923-01) expands the medical application of Geographic Information Systems (GIS) by integrating a geographic information system with CHICA. To provide knowledge management support for CHICA-GIS, three informationists at the Indiana University School of Medicine were awarded a supplement from the National Library Medicine. The ...

Improving Cultural Approaches To Pediatric Palliative Care In Central Massachusetts, Nancy E. Harger, Rn, Ms Lis, Usmani Naheed, Md, Jennifer Costa, Pnp, Estela Mcdonough

Library Publications and Presentations

Objectives: To determine the impact of a web tool developed to improve health care providers' ability and comfort in caring for a diverse patient population in the hospital setting.

Methods: The pediatric palliative care team including a pediatric oncologist and a nurse practitioner in association with a clinical medical librarian and a hospital-based interpreter, collaborated to create a resource using SpringShare software to create a library guide. The purpose is to provide cultural and palliative care information resources, books, and journal articles to assist health care workers at UMass Memorial Children's Medical Center in caring for children from the ...

Adherence To Clean Intermittent Catheterization Treatment In Pediatric Patients: A Comprehensive Review Of Literature, Amanda J. Miller, Ashley R. Thompson

The Research and Scholarship Symposium

No abstract provided.

Genetic Modification Of The Association Between Peripubertal Dioxin Exposure And Pubertal Onset In A Cohort Of Russian Boys, Olivier Humblet, Susan A. Korrick, Paige L. Williams, Oleg Sergeyev, Claude Emond, Linda S. Birnbaum, Jane S. Burns, Larisa Altshul, Donald G. Patterson Jr., Wayman E. Turner, Mary M. Lee, Boris Revich, Russ Hauser

Cell and Developmental Biology Publications and Presentations

BACKGROUND: Exposure to dioxins has been associated with delayed pubertal onset in both epidemiologic and animal studies. Whether genetic polymorphisms may modify this association is currently unknown. Identifying such genes could provide insight into mechanistic pathways. This is one of the first studies to assess genetic susceptibility to dioxins.

OBJECTIVES: We evaluated whether common polymorphisms in genes affecting either molecular responses to dioxin exposure or pubertal onset influence the association between peripubertal serum dioxin concentration and male pubertal onset.

METHODS: In this prospective cohort of Russian adolescent boys (n = 392), we assessed gene-environment interactions for 337 tagging single-nucleotide polymorphisms (SNPs ...

Healthcare Seeking For Diarrhoea, Malaria And Pneumonia Among Children In Four Poor Rural Districts In Sierra Leone In The Context Of Free Health Care: Results Of A Cross-Sectional Survey, Theresa Diaz, Asha S. George, Sowmya R. Rao, Peter S. Bangura, John B. Baimba, Shannon A. Mcmahon, Augustin Kabano

Quantitative Health Sciences Publications and Presentations

BACKGROUND: To plan for a community case management (CCM) program after the implementation of the Free Health Care Initiative (FHCI), we assessed health care seeking for children with diarrhoea, malaria and pneumonia in 4 poor rural districts in Sierra Leone.

METHODS: In July 2010 we undertook a cross-sectional household cluster survey and qualitative research. Caregivers of children under five years of age were interviewed about healthcare seeking. We evaluated the association of various factors with not seeking health care by obtaining adjusted odds ratios and 95% confidence limits using a multivariable logistic regression model. Focus groups and in-depth interviews of ...

Double Diabetes: The Evolving Treatment Paradigm In Children And Adolescents, Benjamin U. Nwosu

Endocrinology/Diabetes

The global pandemic of obesity in children and adolescents has resulted in a new expression of diabetes mellitus designated as double diabetes. The entity encompasses the autoimmune load of Type 1 Diabetes and the metabolic load of Type 2 Diabetes. There is no consensus on the best therapeutic modality for this new expression of diabetes mellitus. Optimal therapeutic options must address the coexistence of both metabolic and autoimmune components of diabetes mellitus in the patient. There have also been calls to revise the current classification of diabetes mellitus to take into account the surging prevalence of double diabetes in children ...

Antisense Oligonucleotide Mediated Therapy Of Spinal Muscular Atrophy, Senthilkumar Sivanesan, Matthew D. Howell, Christine J. Didonato, Ravindra N. Singh

Biomedical Sciences Publications and Papers

Spinal muscular atrophy (SMA) is the leading genetic cause of infant mortality. SMA results from deletions or mutations of survival motor neuron 1 (SMN1), an essential gene. SMN2, a nearly identical copy, can compensate for SMN1 loss if SMN2 exon 7 skipping is prevented. Among the many cis-elements involved in the splicing regulation of SMN exon 7, intronic splicing silencer N1 (ISS-N1) has emerged as the most effective target for an antisense oligonucleotide (ASO)-mediated splicing correction of SMN2 exon 7. Blocking of ISS-N1 by an ASO has been shown to fully restore SMN2 exon 7 inclusion in SMA patient ...

The Study Of Hiv And Antenatal Care Integration In Pregnancy In Kenya: Design, Methods, And Baseline Results Of A Cluster-Randomized Controlled Trial, Janet M. Turan, Rachel L. Steinfeld, Maricianah Onono, Elizabeth A. Bukusi, Meghan Woods, Starley B. Shade, Sierra Washington, Reson Marima, Jeremy Penner, Marta L. Ackers, Dorothy Mbori-Ngacha, Craig R. Cohen

Pathology

Background: Despite strong evidence for the effectiveness of anti-retroviral therapy for improving the health of women living with HIV and for the prevention of mother-to-child transmission (PMTCT), HIV persists as a major maternal and child health problem in sub-Saharan Africa. In most settings antenatal care (ANC) services and HIV treatment services are offered in separate clinics. Integrating these services may result in better uptake of services, reduction of the time to treatment initiation, better adherence, and reduction of stigma.

Methodology/Principal Findings: A prospective cluster randomized controlled trial design was used to evaluate the effects of integrating HIV treatment into ...

Breastfeeding Among Infants With Neonatal Abstinence Syndrome And Mothers Addicted To Narcotics, Landon Bundenthal

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

50,000 infants born in the U.S yearly receive medical treatment for maternal drug use while pregnant. Breastfeeding is associated with decreased maternal use of drugs or alcohol. Breast milk lessens side effects of drug withdrawal for infant. Breastfeeding is associated with decreased cases of necrotizing enter colitis and a significant decrease in hospitalization time. Drug dependent mothers have very low rate of breastfeeding. The purpose of this study is to determine if mothers who are using opioids or methadone should be encouraged to breastfeed.

Adherence To Clean Intermittent Catheterization Treatment In Pediatric Patients: A Comprehensive Review Of Literature, Amanda Miller, Ashley Thompson

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Clean Intermittent Catheterization (CIC) was first introduced by Lapides, et al, in 1972 and has revolutionized management of voiding dysfunction through decreasing urological complications. CIC is an invasive procedure where a clean catheter is introduced into the bladder in order to empty it. The procedure can be done by the patient or caregiver and is usually performed 4-5 times a day. The World Health Organization defines adherence as the extent to which a person’s behavior corresponds with agreed recommendations from a health care professional. Non-adherence to CIC causes many urological complications, including UTIs, epididymitis, and decreasing renal function. The ...

Kangaroo Mother Care For Premature And Low Birthweight Infants, Emma Rahn, Bethany Hotchkiss

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Due to an overwhelming number of babies born prematurely each year, new Interventions are being Introduced and studied. Kangaroo Mother Care (KMC), the prolonged skin-to-skin contact between mother/father and the infant, has been studied and has been shown to be a more beneficial alternative to care for both the infant and the parents. The purpose of this paper Is to compare the holistic outcome of KMC to that of conventional care (incubators and radiators). The research team consisted of two Cedarville nursing students, Emma Rahn and Bethany Hotchkiss. For our paper, the Iowa model was used to guide our ...

A Review Comparing The Most Beneficial Regimens Of Cleansing An Umbilical Cord Before Detachment, Caitlyn Seegers, Mary Burkholder, Ellen Moore

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

This review was conducted because an umbilical cord infection is one of the leading causes of death in neonates. “Newborn cord care practices may directly contribute to infections, which account for a large proportion of the four million annual global neonatal deaths (Alam).” Previous studies have shown that there are multiple ways to care for an umbilical cord stub before detachment. Chemical and natural regimens have been proven to be significant in decreasing omphalitis in neonates. One of the most susceptible areas to bacterial colonization for a neonate is the umbilicus. The purpose of this study is to determine the ...

Neonate Abstinence Syndrome And Therapeutic Interventions, Erica Danner

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

The impact of drug use by mothers to fetus’ in utero is critical not only to their growth and development but also has huge implications for sudden withdrawal at birth. Medication is used for neonates along with many other therapeutic techniques. With drug use for pregnant mothers rising, the incidence for NAS is significant. Hospitals are faced with lengthy hospital stays for neonates as well as providing environments appropriate for these newborns. Neonatal Abstinence Syndrome has risen in opioid dependency alone from 26.4% in 2000 to 41.7% in 2008. As national drug use is increasing, Neonatal Abstinence Syndrome ...

Skin-To-Skin Care Related To Thermoregulation, Becky Wunderlich, Hannah Elwell

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Skin-to-skin contact can reduce neonatal mortality or morbidity by 18-42%. After birth temperature regulation is essential in newborn babies. Skin-to-skin benefits include: regulating heart rate, temperature, and respirations; greater weight gain. The purpose of this study is to determine if skin-to-skin care is more efficient in stabilizing the temperature of a full-term infant than using a radiant warmer. If so, why are radiant warmers still used on health full-term infants if skin-to-skin has more benefits?

Pulse Oximetry Testing For Screening For Congenital Heart Defects In Newborns: A Literature Review Of The Effectiveness And Accuracy, Amanda Custer, Bethany Teixeira

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Pulse oximetry detects the level of oxygen in the blood. A deficiency of oxygen can indicate the presence of CHD. Congenital Heart Defects (CHD) are the number one birth defect in newborns • CHD contributes to 3% of infant mortality and 46% of deaths from congenital malformations in the first year of life

The Effectiveness Of Music Therapy In The Pediatric Population, Megan Brewer, Jaclyn Lewis

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Music therapy (MT) is defined as, “the systematic use of music or musical elements-along with the resulting interpersonal relationship with a trained music therapist to achieve optimal health outcomes…” (The Effectiveness, 2010). Nurses are able to implement music therapy in care. Decreasing fear, anxiety, and ultimately pain will enhance the patient’s experience at the hospital and will lessen the burden of performing care on the patient, decrease stress on caregivers, and ease the provision of care on health professionals.

The Wrap-Up: A Unique Forum To Support Pediatric Residents When Faced With The Death Of A Child, Scot T. Bateman, Rebecca D. Dixon, Maria Trozzi

Pediatric Publications and Presentations

Abstract Objective: The project intended to describe the format of the Wrap-up, a unique multidisciplinary guided debriefing following a child's death. Specific feedback from pediatric residents was sought to assess the model.

Methods: The Wrap-ups were timely (within 48 hours of a death), consistent (conducted after each pediatric intensive care unit (PICU) death), multidisciplinary (all care providers were invited), and specifically conducted by someone trained in postdeath facilitation. The role of the conductor was focused on being inclusive, navigating the discussion, diffusing areas of conflict or angst, and managing the tone of the meeting. Resident feedback was obtained by ...