Integrative Medicine Commons^™

Higher Efficacy In The Treatment Of Fibromyalgia With Duloxetine And Pregabalin Combination Than Monotherapy, Joel Rose-Kamprath

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using:

Gilron I, Chaparro LE, Tu D, et al. Combination of pregabalin with duloxetine for fibromyalgia. Pain. 2016;157(7):1532–1540. https://doi.org/10.1097/j.pain.0000000000000558

for a patient with chronic pain due to fibromyalgia

Downward Spiral, Meghan Hickey

Akesis

There are still moments when I find myself folding inwards: sinking, spiraling, struggling. I become attacked by my own intrusive thoughts. I’ve been my own monster all along.

It took me a long time to understand that progress is never linear. And I bring that idea into my PT practice. I want my patients to understand that set backs, both mental and physical, can occur throughout the healing journey. I often tell my patients expressing anxieties and concerns to observe the way they speak to themselves. Our self talk is influenced by our subconscious mind, and it reveals our ...

Deeply Rooted, Maryam Nahidian

Akesis

I captured this photo on my first solo hike, a very memorable moment for me. I was tired and questioning why I was putting myself in this position. No one would know if I turned back, but I would. Right at that moment, I stopped looking down at my feet and looked up at this scene. “Oh wow,” I said. The trees, strong and tall, but that was not what captured my attention. It was the roots. Exposed, intricate, and vulnerable and I realized at that moment that this scene portrayed me. The journey has been an uphill climb that ...

Pharmacologic Ascorbic Acid As Early Therapy For Hospitalized Patients With Covid-19: A Randomized Clinical Trial, Dagan Coppock, Pierre-Christian Violet, Gustavo Vasquez, Katherine Belden, Michael Foster, Bret Mullin, Devon Magee, Isabelle Mikell, Lokesh Shah, Victoria Powers, Brian Curcio, Constantine Daskalakis, Daniel A. Monti, Mark Levine

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Despite the widespread availability of effective vaccines, new cases of infection with severe acute respiratory syndrome coronavirus-2, the cause of coronavirus disease 2019 (COVID-19), remain a concern in the settings of vaccine hesitancy and vaccine breakthrough. In this randomized, controlled, phase 2 trial, we hypothesized that high-dose ascorbic acid delivered intravenously to achieve pharmacologic concentrations may target the high viral phase of COVID-19 and thus improve early clinical outcomes. Sixty-six patients admitted with COVID-19 and requiring supplemental oxygen were randomized to receive either escalating doses of intravenous ascorbic acid plus standard of care or standard of care alone. The demographic ...

Cerebral Blood Flow And Brain Functional Connectivity Changes In Older Adults Participating In A Mindfulness-Based Stress Reduction Program, Aleeze Sattar Moss, Diane K. Reibel, Nancy Wintering, Faezeh Vedaei, Hannah Porter, Mohsen Khosravi, Justin Heholt, M. Alizadeh, Feroze Mohamed, Andrew B. Newberg

Department of Radiology Faculty Papers

There is a growing interest in the potential beneficial effects of mindfulness meditation training in protecting against age-related physical, emotional, and cognitive decline. The current prospective, single-center, single-arm study investigated if functional magnetic resonance imaging-based changes in cerebral blood flow and brain functional connectivity could be observed in 11 elderly adults (mean age 79) after participation in a Mindfulness-Based Stress Reduction (MBSR) program. The results showed significantly (p < 0.05) altered cerebral blood flow and functional connectivity in the cingulate gyrus, limbic structures, and subregions of the temporal and frontal lobes, similar to findings of other meditation-related studies in younger populations. Furthermore, these changes were also associated with significant improvements in depression symptoms. This study suggests that the MBSR program can potentially modify cerebral blood flow and connectivity in this population.

Spect Functional Neuroimaging Distinguishes Adult Attention Deficit Hyperactivity Disorder From Healthy Controls In Big Data Imaging Cohorts, Daniel G Amen, Theodore A Henderson, Andrew Newberg

Marcus Institute of Integrative Health Faculty Papers

Background: The diagnosis of attention deficit hyperactivity disorder (ADHD) relies on history and observation, as no reliable biomarkers have been identified. In this study, we compared a large single diagnosis group of patients with ADHD (combined, inattentive, and hyperactive) to healthy controls using brain perfusion single-photon emission computed tomography (SPECT) imaging to determine specific brain regions which could serve as potential biomarkers to reliably distinguish ADHD. Methods: In a retrospective analysis, subjects (n = 1,135) were obtained from a large multisite psychiatric database, where resting state (baseline) and on-task SPECT scans were obtained. Only baseline scans were analyzed in the ...

Gender Differences In Urothelial Bladder Cancer: Effects Of Natural Killer Lymphocyte Immunity, Charles T. Lutz, Lydia Livas, Steven R. Presnell, Morgan Sexton, Peng Wang

Pathology and Laboratory Medicine Faculty Publications

Men are more likely to develop cancer than women. In fact, male predominance is one of the most consistent cancer epidemiology findings. Additionally, men have a poorer prognosis and an increased risk of secondary malignancies compared to women. These differences have been investigated in order to better understand cancer and to better treat both men and women. In this review, we discuss factors that may cause this gender difference, focusing on urothelial bladder cancer (UBC) pathogenesis. We consider physiological factors that may cause higher male cancer rates, including differences in X chromosome gene expression. We discuss how androgens may promote ...

A Telephone-Adapted Mindfulness-Based Stress Reduction Program: Preliminary Effects Among Healthcare Employees, Lauren A Zimmaro, Aleeze Sattar Moss, Diane K. Reibel, Elizabeth A Handorf, Jennifer B Reese, Carolyn Y Fang

Marcus Institute of Integrative Health Faculty Papers

Healthcare employees often experience high stress and may benefit from accessible psychosocial interventions. In this pilot study, we explored preliminary feasibility, acceptability, and psychological effects of a telephone-based adaption of mindfulness-based stress reduction (MBSR) for healthcare employees. Eleven participants (M age = 49.9; 27.3% ethnic/racial minority) were enrolled in an eight-session group-based MBSR program adapted for telephone delivery. Feasibility was assessed using rates of program attrition and session completion; acceptability was explored qualitatively via participants' responses to an open-ended item about their program experience. Participants also completed pre-and post-program assessments on psychosocial outcomes (distress (overall distress, depression, anxiety ...

Neuroendocrine Carcinoma Of The Breast: A Case Report, Iulia Gîvan, George Ciulei, Angela Cozma, Mădălina Gabriela Indre, Vlad Țâru, Anca Pop, Adela Sitar Tăut, Simina Țărmure, Vasile Negrean, Olga Hilda Orășan

Journal of Mind and Medical Sciences

Neuroendocrine breast carcinomas represent a rare subtype of breast cancer. Their definition, prevalence and prognosis remain controversial in the literature. Regarding the presentation, there are no differences from other breast carcinomas and clinical syndromes related to hormone production are extremely rare. Refinement of the classification of neuroendocrine neoplasms of the breast is needed in order to improve the reproducibility of their diagnostic criteria and to define their clinical significance.

This article presents the case of a 44-year-old female patient diagnosed with invasive breast carcinoma with neuroendocrine features, according to the 2012 World Health Organization (WHO) definition, with focus on presentation ...

Desire For Control Moderates The Relationship Between Perceived Control And Depressive Symptomology, Liam Alexander Mackenzie Myles, Emanuele Maria Merlo, Antonia Obele

Journal of Mind and Medical Sciences

Background. The prevalence of psychological difficulties is rising at an alarming rate, with an increasing number of individuals reporting symptoms of depression. A decline in both perceived control and desire for control has previously been associated with the onset of depression. However, previous research has failed to examine whether perceived control and desire for control interact in their relationship with depressive symptomology. Methods. A sample of 350 participants completed the Spheres of Control Scale, the Desirability of Control Scale and Beck’s Depression Inventory. Process Macro was used to examine whether desire for control moderated the relationship between perceived control ...

Effect Of Presence And Absence Of Parents On The Emotional Maturity And Perceived Loneliness In Adolescents, Sana Fatima, Momal Bashir, Kainat Khan, Sheeza Farooq, Sidra Shoaib, Sheeba Farhan

Journal of Mind and Medical Sciences

The present study was conducted to examine the Emotional Maturity and Perceived Loneliness of adolescents with respect to the presence and absence of parents. It was hypothesized that the absence or presence of parents of adolescents would affect the level of emotional maturity and perceived loneliness among adolescents. The adolescent participants N=250 (males n=125 and females n=125; age range= 13-18; M=16.63; SD=0.87) were approached through purposive convenient sampling technique. Measures included the Emotional Maturity Scale and the UCLA loneliness scale V-III. Results indicated that adolescent who lived with their guardians had greater perceived ...

Role Of Emotional Intelligence In Job Performance Of Healthcare Providers Working In Public Sector Hospitals Of Pakistan, Nimra Zaman, Khalida Naz Memon, Faryal Zaman, Komal Zaman Khan, Shazia Rahman Shaikh

Journal of Mind and Medical Sciences

Objective. To determine the association between emotional intelligence (EI) and job performance (JP) of health care providers (HCPs). Methods. Healthcare professionals from various hospitals were chosen for a cross-sectional study. The survey was conducted using a three-part questionnaire including the demographic profile, Wong and Law Emotional Intelligence (EI) Scale, and an individual work performance (JP) questionnaire. The relationship of predictor variables on JP was sought by applying Chi-square test and multiple regression analysis. Results. About 43.3% of the 50.8% of participants who scored well on the EI scale also scored high on the JP scales. The remaining 7 ...

Therapeutic Efficacy Of Mesenchymal Stem Cells For Cardiovascular Diseases, Dragana Radoje Miloradovic, Dragica Radoje Pavlovic, Miodrag Bozidar Stojkovic, Sanja Bratislav Bojic, Vladislav Bogdan Volarevic, Marina Milosav Gazdic Jankovic, Biljana Tomislav Ljujic

Journal of Mind and Medical Sciences

Despite the improvements in pharmacological and surgical treatments, cardiovascular diseases (CVDs) are the number one cause of death worldwide. During the last two decades, the search for new therapies has been revolutionized with the growing knowledge of stem cell biology. Due to their huge differentiation capacity and paracrine effects, mesenchymal stem cells (MSCs) are a promising tool for the treatment of CVDs. The encouraging outcomes of preclinical studies using MSCs as a treatment for diseased myocardium have set the scene for worldwide clinical trials. In this review, we overview either complete or ongoing clinical trials using MSCs for the therapy ...

Food Addiction And Obesity, Lisa Ling

Electronic Theses and Dissertations

The obesity rate in the U.S. adult population has increased to epidemic levels despite attempts to decrease obesity through evidence-based knowledge, clinical practice guidelines, medical interventions, and individual efforts. For certain individuals, food addiction behaviors such as food cravings, loss of control, and binge eating contribute to obesity and require a different approach to care. Little work has been done on adding the possibility of food addiction to obesity screening and treatment. This study utilized a quasi-experimental quantitative pre- and postsurvey research design based on Lewin’s change theory. Nurse practitioners were surveyed regarding the provider’s perceptions, attitudes ...

Medical Schools Ignore The Nature Of Consciousness At Great Cost, Anoop Kumar

Journal of Wellness

The essential question of the relationship between consciousness and matter is ignored in medical school curricula, leading to a machine-like view of the human being that contributes to physician burnout and intellectual dissatisfaction. The evidence suggesting that the brain may not be the seat of consciousness is generally ignored to preserve the worldview of the primacy of matter. By investigating new frameworks detailing the nature of consciousness at different levels of hierarchy, we can bring intellectual rigor to a once opaque subject that supports a fundamental reality about our experience: We are human beings, not only human bodies.

Depression Predicts Chronic Pain Interference In Racially-Diverse, Low-Income Patients [Preprint], Benjamin C. Nephew, Angela C. Incollingo Rodriguez, Veronica Melican, Justin J. Polcari, Kathryn E. Nippert, Mikhail Rashkovskii, Lilly-Beth Linnell, Ruofan Hu, Carolina Ruiz, Jean A. King, Paula Gardiner

UMass Chan Medical School Faculty Publications

Background Chronic pain is one of the most common reasons adults seek medical care in the US, with estimates of prevalence ranging from 11% to 40%. Mindfulness meditation has been associated with significant improvements in pain, depression, physical and mental health, sleep, and overall quality of life. Group medical visits are increasingly common and are effective at treating myriad illnesses including chronic pain. Integrative Medical Group Visits (IMGV) combine mindfulness techniques, evidence based integrative medicine, and medical group visits and can be used as adjuncts to medications, particularly in diverse underserved populations with limited access to non-pharmacological therapies.

Objective and ...

Project Echo And Primary Care Buprenorphine Treatment For Opioid Use Disorder: Implementation And Clinical Outcomes, James B. Anderson, Stephen A. Martin, Anne Gadomski, Nicole Krupa, Daniel J. Mullin, Amber Cahill, Paul Jenkins

UMass Chan Medical School Faculty Publications

Background: Our rural health system sought to (1) increase the number of primary care clinicians waivered to prescribe buprenorphine for treatment of opioid use disorder (OUD) and (2) consequently increase the number of our patients receiving this treatment.

Methods: We used the Project for Extension for Community Health Outcomes (ECHO) tele-education model as an implementation strategy. We examined the number of clinicians newly waivered, the number of patients treated with buprenorphine, the relationship between clinician engagement with ECHO training and rates of buprenorphine prescribing, and treatment retention at 180 days.

Results: The number of clinicians with a waiver and number ...

Leaning Into Whole Health: Sustaining System Transformation While Supporting Patients And Employees During Covid-19, Eileen M. Dryden, Rendelle E. Bolton, Barbara G. Bokhour, Juliet Wu, Kelly Dvorin, Lauri Phillips, Justeen K. Hyde

Open Access Publications by UMass Chan Authors

Background: The US Veterans Health Administration (VA) is transforming its healthcare system to create a Whole Health System (WHS) of care. Akin to such reorganization efforts as creating patient-centered medical homes and primary care behavioral health integration, the WHS goes beyond by transforming the entire system to one that takes a proactive approach to support patient and employee health and wellness. The SARS-CoV-2 pandemic disrupted the VA's healthcare system and added stress for staff and patients, creating an exogenous shock for this transformation towards a WHS.

Objective: We examined the relationship between VA's WHS transformation and the pandemic ...

Music As A Gateway To Healing Speech Disorders And Mental Health Holistically In The Patient With Aphasia: A Literature Review, Susan Warren

Expressive Therapies Capstone Theses

People with some types of post-stroke aphasia often experience depression as well as loss of speech. Music therapy has unique properties that allow it to be used therapeutically to treat both speech impairment and depression yet it is rarely used to treat both disorders. This literature review seeks to examine the underlying causes for this discrepancy, review methods used by practitioners to treat both disorders and suggest future directions for additional research and implications for the treatment of patients with aphasia who have both language impairment and depression.

A Holistic Approach To Physical And Mental Health: Associations Between Chronic Disease And Psychiatric Conditions, Pooja Patel, Alison Mancuso

Stratford Campus Research Day

OBJECTIVE:

• To investigate the link between chronic medical conditions and psychiatric disorders

BACKGROUND

• Limited research has been done studying the relationship between chronic medical conditions and psychiatric disorders in patients comorbid with both types of conditions.

• Prior research studies have demonstrated that patients with chronic medical conditions are more likely to develop psychiatric disorders compared to healthy individuals without any medical conditions.

• As individuals develop chronic medical conditions, they may encounter additional obstacles in their lives,