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Obstetrics and Gynecology Commons

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Novel Collaborative Cardiology And Maternal Fetal Medicine Practice – Continued Experience At The Heart And Pregnancy Program, Joanne Quiñones MD, MSCE, Margaret Bettin, Irena B. Cabrera MD, Adetola Louis-Jacques MD, Amy M. Ahnert MD, Ronald S. Freudenberger MD 2016 Lehigh Valley Health Network

Novel Collaborative Cardiology And Maternal Fetal Medicine Practice – Continued Experience At The Heart And Pregnancy Program, Joanne Quiñones Md, Msce, Margaret Bettin, Irena B. Cabrera Md, Adetola Louis-Jacques Md, Amy M. Ahnert Md, Ronald S. Freudenberger Md

Ronald S Freudenberger MD

No abstract provided.


Length Of The Second Stage Of Labor And Risk Of Preterm Delivery In A Subsequent Pregnancy, Joanne Quiñones MD, MSCE, Daniel Gomez MD, Matthew Hoffman MD, Cande V. Ananth PhD, John C. Smulian MD, MPH, Lauren A. Plante MD, Daniel W. Skupsk MD, Karin M. Fuchs MD, William E. Scorza MD 2016 Lehigh Valley Health Network

Length Of The Second Stage Of Labor And Risk Of Preterm Delivery In A Subsequent Pregnancy, Joanne Quiñones Md, Msce, Daniel Gomez Md, Matthew Hoffman Md, Cande V. Ananth Phd, John C. Smulian Md, Mph, Lauren A. Plante Md, Daniel W. Skupsk Md, Karin M. Fuchs Md, William E. Scorza Md

John C Smulian MD, MPH

No abstract provided.


Characterization Of Babies Discharged From Cabell Huntington Hospital During The Calendar Year 2005 With The Diagnoses Of Neonatal Abstinence Syndrome, F. Ross Baxter MD, Robert Nerhood MD, David Chaffin MD 2016 Marshall University

Characterization Of Babies Discharged From Cabell Huntington Hospital During The Calendar Year 2005 With The Diagnoses Of Neonatal Abstinence Syndrome, F. Ross Baxter Md, Robert Nerhood Md, David Chaffin Md

David G. Chaffin

Recent concern regarding the impact of maternal drug abuse on neonatal well-being was the impetus for this retrospective cohort study of newborns diagnosed with neonatal abstinence syndrome that were discharged from Cabell Huntington Hospital during the calendar year 2005. Medical records of the neonates and their mothers were analyzed for a variety of health related outcomes and healthcare cost. Forty-eight neonates were diagnosed with Neonatal Abstinence Syndrome in 2005, forty of which required NICU assistance. The average maternal age at delivery was 26; gravity was 3.1 and most were single, separated or divorced. The majority had poor or inconsistent ...


Recruitment Feasibility Study For Reducing Postpartum Smoking Among Low-Income And Hispanic Women, Helai Hesham MD, Sandra L. Curet MD, Suresh G. Nair MD, Hope Kincaid MPH, CPH, Cynthia Beitler, Lourdes T. Matos, Clare Lenhart PhD, MPH 2016 Lehigh Valley Health Network

Recruitment Feasibility Study For Reducing Postpartum Smoking Among Low-Income And Hispanic Women, Helai Hesham Md, Sandra L. Curet Md, Suresh G. Nair Md, Hope Kincaid Mph, Cph, Cynthia Beitler, Lourdes T. Matos, Clare Lenhart Phd, Mph

Suresh G. Nair MD

No abstract provided.


Abdominal Resection Of A Cornual Heterotopic Pregnancy Using Intraoperative Ultrasound: Case Report, Abigail Mancuso, Adrianne Racek, E. Hakan Duran 2016 University of Iowa Hospitals and Clinics, Department of Obstetrics and Gynecology, Iowa City, Iowa

Abdominal Resection Of A Cornual Heterotopic Pregnancy Using Intraoperative Ultrasound: Case Report, Abigail Mancuso, Adrianne Racek, E. Hakan Duran

POG In Press

Background: Heterotopic pregnancy is a rare complication of in vitro fertilization (IVF) and diagnosis and treatment can be challenging, particularly with unusual ectopic sites and desire to maintain the intrauterine pregnancy.

Case: We review the case of a 29-year-old female who presented with a cornual heterotopic pregnancy following IVF treated with exploratory laparotomy and ultrasound guided resection of the cornual pregnancy, resulting in an ongoing viable singleton intrauterine pregnancy.

Conclusion: The management of cornual heterotopic pregnancies is limited by lack of data regarding ideal treatment although several surgical and non-surgical strategies have been described. This case uses abdominal resection of ...


Treatment Of Hailey-Hailey Disease Of The Vulva: A Retrospective Case Series, Avery M. Whitis, Diane Elas, Karla Solheim, Colleen K. Stockdale 2016 University of Iowa Carver College of Medicine, Iowa City, Iowa

Treatment Of Hailey-Hailey Disease Of The Vulva: A Retrospective Case Series, Avery M. Whitis, Diane Elas, Karla Solheim, Colleen K. Stockdale

POG In Press

Background: Hailey-Hailey disease (familial benign chronic pemphigus) of the vulva is a rare autosomal dominant dermatosis characterized by malformation of desmosomes and bullae, particularly in intertriginous areas.

Cases: We reviewed the cases of 5 women followed at a single academic institution over a period of 17 years. Of the 5 patients, 4 carried a diagnosis of Hailey-Hailey at the time of presentation to our institution, and one was diagnosed on biopsy. 3 were members of a family group. Initial treatment of choice was a topical steroid (betamethasone in 3, fluocinonide and hydrocortisone in 1 each), vulvar skin guidelines, tepid soaks ...


Two Patients With Germline Mutations In Both Brca1 And Brca2 Discovered Unintentionally: A Case Series And Discussion Of Brca Testing Modalities, Ann Marie Augustyn, Nicole M. Agostino DO, Tara Namey, Suresh G. Nair MD, Martin A. Martino MD 2016 Lehigh Valley Health Network

Two Patients With Germline Mutations In Both Brca1 And Brca2 Discovered Unintentionally: A Case Series And Discussion Of Brca Testing Modalities, Ann Marie Augustyn, Nicole M. Agostino Do, Tara Namey, Suresh G. Nair Md, Martin A. Martino Md

Suresh G. Nair MD

No abstract provided.


Model Assessment And Development Of Risk Stratification Of Surgical Site Infection Following Cesarean Delivery For A High-Risk, Urban Population, Dakisha N. Lewis, Nicole P. Salvo, Kiley A. Bernhard, Danielle M. Greer 2016 Department of Obstetrics and Gynecology, Aurora Sinai Medical Center

Model Assessment And Development Of Risk Stratification Of Surgical Site Infection Following Cesarean Delivery For A High-Risk, Urban Population, Dakisha N. Lewis, Nicole P. Salvo, Kiley A. Bernhard, Danielle M. Greer

Nicole P. Salvo, MD

Background: Surgical site infection (SSI) remains a major cause of morbidity despite efforts aimed at prevention and treatment. Risk stratification tools identify patients at greatest risk of SSI. Two models of stratification are: 1) the Centers for Disease Control and Prevention’s National Healthcare Safety Network SSI Risk Index (NHSN), which assigns risk based on surgery duration, surgical wound contamination and physical status; and 2) the New Risk Stratification Schema (NRSS). The NRSS aimed to improve upon NHSN by incorporating five variables: diabetes control, body mass index (BMI), chorioamnionitis, methods of placental extraction and skin closure.

Purpose: Our objectives were ...


Model Assessment And Development Of Risk Stratification Of Surgical Site Infection Following Cesarean Delivery For A High-Risk, Urban Population, Dakisha N. Lewis, Nicole P. Salvo, Kiley A. Bernhard, Danielle M. Greer 2016 Department of Obstetrics and Gynecology, Aurora Sinai Medical Center

Model Assessment And Development Of Risk Stratification Of Surgical Site Infection Following Cesarean Delivery For A High-Risk, Urban Population, Dakisha N. Lewis, Nicole P. Salvo, Kiley A. Bernhard, Danielle M. Greer

Nicole Salvo, MD

Background: Surgical site infection (SSI) remains a major cause of morbidity despite efforts aimed at prevention and treatment. Risk stratification tools identify patients at greatest risk of SSI. Two models of stratification are: 1) the Centers for Disease Control and Prevention’s National Healthcare Safety Network SSI Risk Index (NHSN), which assigns risk based on surgery duration, surgical wound contamination and physical status; and 2) the New Risk Stratification Schema (NRSS). The NRSS aimed to improve upon NHSN by incorporating five variables: diabetes control, body mass index (BMI), chorioamnionitis, methods of placental extraction and skin closure.

Purpose: Our objectives were ...


A Pilot Study To Assess The Feasibility, Safety And Acceptability Of Soy-Based Diet For Pregnant Women At High Risk For Gestational Diabetes Mellitus, Ling Shi, Vidya Iyer, Emily Jones, Tiffany A. Moore Simas, Alice H. Lichtenstein, Laura L. Hayman 2016 University of Massachusetts Boston

A Pilot Study To Assess The Feasibility, Safety And Acceptability Of Soy-Based Diet For Pregnant Women At High Risk For Gestational Diabetes Mellitus, Ling Shi, Vidya Iyer, Emily Jones, Tiffany A. Moore Simas, Alice H. Lichtenstein, Laura L. Hayman

UMass Center for Clinical and Translational Science Research Retreat

Background: Diet plays an important role in the prevention and management of gestational diabetes mellitus (GDM). Previous studies suggest that soy protein and isoflavones may have beneficial effects on lipid and glucose metabolism. Little is known regarding the cardiometabolic effects of soy intake during pregnancy. This pilot study assessed the feasibility, safety and acceptability of daily consumption of soy foods during pregnancy in women at high risk for GDM, and participant adherence to their assigned treatment.

Methods: A randomized controlled trial (RCT) was conducted among pregnant women at high risk for GDM. The Soy group were counseled to consume a ...


Association Between First Trimester Pregnancy Associated Plasma Protein–A And The Development Of Gestational Diabetes Mellitus, Aylin Sert, Katherine Leung, Molly E. Waring, Raziel Rojas-Rodriguez, Silvia Corvera, Tiffany A. Moore Simas 2016 University of Massachusetts Medical School

Association Between First Trimester Pregnancy Associated Plasma Protein–A And The Development Of Gestational Diabetes Mellitus, Aylin Sert, Katherine Leung, Molly E. Waring, Raziel Rojas-Rodriguez, Silvia Corvera, Tiffany A. Moore Simas

UMass Center for Clinical and Translational Science Research Retreat

Background: Gestational diabetes (GDM) is a common pregnancy complication with significant cardiometabolic consequences for mothers and offspring. Previous research from our group suggests that adipose tissue IGFBP-5 and its unique metalloprotease PAPP-A (Pregnancy Associated Plasma Protein-A) may play mechanistic roles in GDM development by regulating functional IGF-1 levels and lipid storage and metabolism.

Aim: To examine the relationship between circulating PAPP-A levels and GDM development. We hypothesized that high first trimester PAPP-A levels would be associated with decreased GDM risk.

Methods: A retrospective cohort of women delivering singleton gestations at UMass Memorial Healthcare (2009, 2010, 2014, 2015) was assembled by ...


Effectiveness And Short-Term Safety Of Modified Sodium Hyaluronic Acid-Carboxymethylcellulose At Cesarean Delivery: A Randomized Trial., Daniel G. Kiefer MD, Jolene C Muscat, Jarrett Santorelli, Martin R Chavez, Cande V. Ananth PhD, MPH, John C. Smulian MD, MPH, Anthony M Vintzileos 2016 Lehigh Valley Health Network

Effectiveness And Short-Term Safety Of Modified Sodium Hyaluronic Acid-Carboxymethylcellulose At Cesarean Delivery: A Randomized Trial., Daniel G. Kiefer Md, Jolene C Muscat, Jarrett Santorelli, Martin R Chavez, Cande V. Ananth Phd, Mph, John C. Smulian Md, Mph, Anthony M Vintzileos

John C Smulian MD, MPH

BACKGROUND: The rising cesarean birth rate has drawn attention to risks associated with repeat cesarean birth. Prevention of adhesions with adhesion barriers has been promoted as a way to decrease operative difficulty. However, robust data demonstrating effectiveness of such interventions are lacking.

OBJECTIVE: We report data from a multicenter trial designed to evaluate the short-term safety and effectiveness of a modified sodium hyaluronic acid (HA)-carboxymethylcellulose (CMC) absorbable for reduction of adhesions following cesarean delivery.

STUDY DESIGN: Patients who underwent primary or repeat cesarean delivery were included in this multicenter, single-blinded (patient), randomized controlled trial. Patients were randomized into either ...


Catecholaminergic Polymorphic Ventricular Tachycardia In Pregnancy., Matthew P. Romagano DO, Joanne Quiñones MD, MSCE, Amy M. Ahnert MD, Rafael E. Martinez MD, John C. Smulian MD, MPH 2016 Lehigh Valley Health Network

Catecholaminergic Polymorphic Ventricular Tachycardia In Pregnancy., Matthew P. Romagano Do, Joanne Quiñones Md, Msce, Amy M. Ahnert Md, Rafael E. Martinez Md, John C. Smulian Md, Mph

John C Smulian MD, MPH

BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia is a genetic disorder in which ventricular tachycardia occurs in the absence of structural heart disease or a prolonged QT interval. If untreated, there is a high incidence of sudden cardiac death. Management of this cardiac condition during pregnancy merits a multidisciplinary approach.

CASE: A nulliparous woman with catecholaminergic polymorphic ventricular tachycardia presented at 15 weeks of gestation. Her care involved a multidisciplinary team including cardiology, maternal-fetal medicine, obstetric nursing, cardiac nursing, and anesthesia. A simulation scenario was designed to prepare for cardiac events during labor. A term intrapartum cesarean delivery was performed for fetal ...


Characterization And Small Rna Content Of Extracellular Vesicles In Follicular Fluid Of Developing Bovine Antral Follicles., Raphatphorn Navakanitworakul, Wei-Ting Hung, Sumedha Gunewardena, John S. Davis, Wilaiwan Chotigeat, Lane K. Christenson 2016 University of Kansas Medical Center

Characterization And Small Rna Content Of Extracellular Vesicles In Follicular Fluid Of Developing Bovine Antral Follicles., Raphatphorn Navakanitworakul, Wei-Ting Hung, Sumedha Gunewardena, John S. Davis, Wilaiwan Chotigeat, Lane K. Christenson

Journal Articles: Obstetrics & Gynecology

Exosomes and microvesicles (i.e., extracellular vesicles: EVs) have been identified within ovarian follicular fluid and recent evidence suggests that EVs are able to elicit profound effects on ovarian cell function. While existence of miRNA within EVs has been reported, whether EV size and concentration as well as their cargos (i.e., proteins and RNA) change during antral follicle growth remains unknown. Extracellular vesicles isolated from follicular fluid of small, medium and large bovine follicles were similar in size, while concentration of EVs decreased progressively as follicle size increased. Electron microscopy indicated a highly purified population of the lipid bilayer ...


Identifying Barriers To Accessing Information And Treatment For Obstetric Fistula In Niamey, Niger, Marielle E. Meurice, Rene R. Genadry, Catherine S. Bradley, Benajamin Majors, Sanda O. Ganda 2016 University of Iowa Carver College of Medicine, Iowa City, Iowa

Identifying Barriers To Accessing Information And Treatment For Obstetric Fistula In Niamey, Niger, Marielle E. Meurice, Rene R. Genadry, Catherine S. Bradley, Benajamin Majors, Sanda O. Ganda

POG In Press

Objective: To identify barriers to accessing information and treatment regarding obstetric fistula (OF) unique to Niger encountered by women referred to the National Referral Fistula Center.

Method: A questionnaire was administered at the National Referral Fistula Center to 29 women with OF. Qualitative and quantitative statistics were computed.

Results: The average individual was 30.4 years old, illiterate and from a rural area. 76.0% had antenatal care, the average labor time was 3.04 days, and 88.0% had a physician-assisted delivery. Barriers to information included rural dwelling, lack of education, lack of understanding of cause despite contact with ...


Positive Deviance, Contraceptive Self-Efficacy And Social Desirability In Sexually Active Adolescent Females : A Mixed Methods Approach., Ashley D. Miller 2016 University of Louisville

Positive Deviance, Contraceptive Self-Efficacy And Social Desirability In Sexually Active Adolescent Females : A Mixed Methods Approach., Ashley D. Miller

Electronic Theses and Dissertations

Unintended pregnancy is an issue that impacts women of all ages, ethnicities, and socioeconomic statuses. It also impacts the child that results and the society in which they live. In the United States, adolescents experience unintended pregnancy more than adolescents in other countries. The purpose of this dissertation was to explore the factors that contribute to successful contraceptive use among adolescent females (ages 13-18) seeking reproductive health services at a local family planning clinic. The theoretical framework of contraceptive self-efficacy (CSE) was used to frame this understanding. The exploration was conducted in three ways: a critical review of the literature ...


Intimate Partner Violence In Early Adolescence: The Role Of Gender, Socioeconomic Factors And The School, A. J. Mason-Jones, P De Koker, S. M. Eggers, Marleen Temmerman, E. Leye, P. J de Vries, H de Vries 2016 University of York

Intimate Partner Violence In Early Adolescence: The Role Of Gender, Socioeconomic Factors And The School, A. J. Mason-Jones, P De Koker, S. M. Eggers, Marleen Temmerman, E. Leye, P. J De Vries, H De Vries

Obstetrics and Gynaecology, East Africa

Background: Intimate partner violence (IPV) among adolescents is common worldwide, but our understanding of perpetration, gender differences and the role of social-ecological factors remains limited.

Objectives: To explore the prevalence of physical and sexual IPV perpetration and victimisation by gender, and associated risk and protective factors.

Methods: Young adolescents (N=2 839) from 41 randomly selected public high schools in the Western Cape region of South Africa (SA), participating in the PREPARE study, completed a self-administered questionnaire.

Results: The participants’ mean age was 13.65 years (standard deviation 1.01), with 19.1% (541/2 839) reporting being victims/survivors ...


Doulas Could Improve Foreign-Born Women’S Perinatal And Postpartum Satisfaction And Increase Health Providers’ Cultural Competency In A Multicultural Urban Area Of The United States., Crystal Kazik 2016 Clark University

Doulas Could Improve Foreign-Born Women’S Perinatal And Postpartum Satisfaction And Increase Health Providers’ Cultural Competency In A Multicultural Urban Area Of The United States., Crystal Kazik

International Development, Community and Environment (IDCE)

Doulas act as a cultural bridge between clients and providers through the support, advocacy, and education they provide. Unfortunately, migrant women may be at a disadvantage for accessing and benefiting from their services due to a variety of socioeconomic and cultural factors including predisposed ideas of care and structure based on experiences in native countries, language barriers, lower health literacy, and a lack of awareness and understanding from hospital/clinic staff.

A strategic multifaceted approach utilizing doulas, such as Boston Medical Center’s collaborative and culturally competent model, may greatly improve foreign-born women’s experience and satisfaction with healthcare when ...


Psychobiobehavioral Model For Preterm Birth In Pregnant Women In Low- And Middle-Income Countries, Shahirose S. Premji, Ilona S. Yim, Aliyah Dosani (Mawji), Zeenatkhanu Kanji, Salima Sulaiman, Wangira Musana, Pauline Samia, Kiran Shaikh, Nicole Letourneau 2016 University of Calgary

Psychobiobehavioral Model For Preterm Birth In Pregnant Women In Low- And Middle-Income Countries, Shahirose S. Premji, Ilona S. Yim, Aliyah Dosani (Mawji), Zeenatkhanu Kanji, Salima Sulaiman, Wangira Musana, Pauline Samia, Kiran Shaikh, Nicole Letourneau

Zeenatkhanu Kanji

Preterm birth (PTB) is a final common outcome resulting from many interrelated etiological pathways; of particular interest is antenatal psychosocial distress (i.e., stress, anxiety, and depression). In LMI countries, both exposure to severe life stressors and rate of PTB are on average greater when compared with high-income countries. In LMI countries women are exposed to some of the most extreme psychosocial stress worldwide (e.g., absolute poverty, limited social resources). High prevalence of antenatal stress and depression have been observed in some studies from LMI countries. We propose a psychosocial, biological, and behavioral model for investigating the complex multisystem ...


Association Between First Trimester Pregnancy Associated Plasma Protein–A (Papp-A) And Gestational Diabetes Mellitus Development, Aylin Sert, Katherine Leung, Molly E. Waring, Raziel Rojas-Rodriguez, Silvia Corvera, Tiffany A. Moore Simas 2016 University of Massachusetts Medical School

Association Between First Trimester Pregnancy Associated Plasma Protein–A (Papp-A) And Gestational Diabetes Mellitus Development, Aylin Sert, Katherine Leung, Molly E. Waring, Raziel Rojas-Rodriguez, Silvia Corvera, Tiffany A. Moore Simas

Senior Scholars Program

Background: Gestational diabetes (GDM) is a common pregnancy complication with significant cardiometabolic consequences for mothers and offspring. Previous research from our group suggests that adipose tissue IGFBP-5 and its unique metalloprotease PAPP-A (Pregnancy Associated Plasma Protein-A) may play mechanistic roles in GDM development by regulating functional IGF-1 levels and lipid storage and metabolism.

Aim: To examine the relationship between circulating PAPP-A levels and GDM development. We hypothesized that high first trimester PAPP-A levels would be associated with decreased GDM risk.

Methods: A retrospective cohort of women delivering singleton gestations at UMass Memorial Healthcare (2009, 2010, 2014 ...


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