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Vulvodynia; An Under-Recognized Disease, Simona Roxana Georgescu, Cristina I. Mitran, Mădălina I. Mitran, Maria I. Sârbu, Mircea Tampa 2016 Carol Davila University, Department of Dermatology and Venereology

Vulvodynia; An Under-Recognized Disease, Simona Roxana Georgescu, Cristina I. Mitran, Mădălina I. Mitran, Maria I. Sârbu, Mircea Tampa

Journal of Mind and Medical Sciences

Vulvodynia is a chronic condition which affects an increasing number of women; it presents currently an incidence that is higher than had previously been estimated. Regarding pathogenesis, several (hormonal, infectious, inflammatory and psychological) factors have been proposed, but vulvodynia etiology remains still unclear. This disorder is a multifactorial condition with a significant impact on the patient’s quality of life, yet is difficult to diagnose (an under-estimated/ under-recognized affection). Certain medical investigations are required in order to exclude other diseases (the diagnosis of vulvodynia being one of exclusion), but anamnesis and physical examination are essential steps in the diagnosis.

Although ...


Dexamethasone For The Prevention Of Neonatal Respiratory Morbidity Before Elective Cesarean Section At Term, Mohammed N. Salem, Ahmed Mohamed Abbas, Mostafa Ashry 2016 Department of Obstetrics and Gynecology, Faculty of Medicine; Sohag University, Sohag, Egypt

Dexamethasone For The Prevention Of Neonatal Respiratory Morbidity Before Elective Cesarean Section At Term, Mohammed N. Salem, Ahmed Mohamed Abbas, Mostafa Ashry

POG In Press

Background: Respiratory distress syndrome (RDS) is the principal cause of early neonatal morbidity and mortality.

Objective: The current study aims to evaluate the effect of dexamethasone administration 48 hours before elective cesarean section (CS) at term on neonatal respiratory morbidity.

Methods: The current study was a case-control study conducted between June 2015 and November 2015. Women who attended the labor ward in Sohag University Hospital, Egypt, after 37 weeks of gestation for elective CS were approached for participation. The patients received 2 intramuscular doses of 12 mg dexamethasone 12 hours apart in the 48 hours before CS (N=246). The ...


What Clinical Interventions Have Been Implemented To Prevent Or Reduce Postpartum Hypertension Readmissions? A Clin-Iq, Sara O'Meara, Molly Lepic 2016 Aurora Sinai Medical Center, Aurora Health Care

What Clinical Interventions Have Been Implemented To Prevent Or Reduce Postpartum Hypertension Readmissions? A Clin-Iq, Sara O'Meara, Molly Lepic

Journal of Patient-Centered Research and Reviews

A literature review was conducted to determine what clinical interventions have been studied and implemented to prevent and/or reduce postpartum hypertension readmissions. Appropriate verbal and printed educational materials should be given to the patient prior to discharge with use of the “teach back” method. Patients and health care providers within the multidisciplinary team should be educated on the warning signs and symptoms of worsening hypertensive disease and when to appropriately involve the obstetrician. The use of text messaging may be useful in preventing hospital readmissions by increasing patient follow-up and compliance and appropriately managing patients in the postpartum period ...


Mater: Innovative Programs For Maternal Addiction Education Treatment And Research, Meghan Gannon PhD MSPH 2016 Thomas Jefferson University

Mater: Innovative Programs For Maternal Addiction Education Treatment And Research, Meghan Gannon Phd Msph

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.


Gestational Age Estimation Based On Fetal Pelvimetry On Fetal Ultrasound In Iraqi Women, Sattar Razzaq Al-Esawi, Niran Mohammed Al-Hashimi, Farah S. Ali, Sarwat Hussain 2016 Al Sader Medical City

Gestational Age Estimation Based On Fetal Pelvimetry On Fetal Ultrasound In Iraqi Women, Sattar Razzaq Al-Esawi, Niran Mohammed Al-Hashimi, Farah S. Ali, Sarwat Hussain

The Journal of Global Radiology

Ultrasound is an integral part of obstetric practice, and assessment of gestational age (GA) is a central element of obstetric ultrasonography. Sonographic estimation of GA is derived from calculations based on fetal measurements. Numerous equations for GA calculation from fetal biometry have been adopted in routine practice. This study reports a new method of estimating GA in the second and third trimester using interischial distance (IID), the distance between the two ischial primary ossification centers, on fetal ultrasound. Four hundred women with uncomplicated normal singleton pregnancies from 16 weeks to term were examined. Standard fetal obstetric ultrasound was done measuring ...


A Pilot Study To Assess The Feasibility, Safety And Acceptability Of Soy-Based Diet For Pregnant Women At High Risk For Gestational Diabetes Mellitus, Ling Shi, Vidya Iyer, Emily Jones, Tiffany A. Moore Simas, Alice H. Lichtenstein, Laura L. Hayman 2016 University of Massachusetts Boston

A Pilot Study To Assess The Feasibility, Safety And Acceptability Of Soy-Based Diet For Pregnant Women At High Risk For Gestational Diabetes Mellitus, Ling Shi, Vidya Iyer, Emily Jones, Tiffany A. Moore Simas, Alice H. Lichtenstein, Laura L. Hayman

Tiffany A. Moore Simas

Background: Diet plays an important role in the prevention and management of gestational diabetes mellitus (GDM). Previous studies suggest that soy protein and isoflavones may have beneficial effects on lipid and glucose metabolism. Little is known regarding the cardiometabolic effects of soy intake during pregnancy. This pilot study assessed the feasibility, safety and acceptability of daily consumption of soy foods during pregnancy in women at high risk for GDM, and participant adherence to their assigned treatment.

Methods: A randomized controlled trial (RCT) was conducted among pregnant women at high risk for GDM. The Soy group were counseled to consume a ...


Novel Collaborative Cardiology And Maternal Fetal Medicine Practice – Continued Experience At The Heart And Pregnancy Program, Joanne Quiñones MD, MSCE, Margaret Bettin, Irena B. Cabrera MD, Adetola Louis-Jacques MD, Amy M. Ahnert MD, Ronald S. Freudenberger MD 2016 Lehigh Valley Health Network

Novel Collaborative Cardiology And Maternal Fetal Medicine Practice – Continued Experience At The Heart And Pregnancy Program, Joanne Quiñones Md, Msce, Margaret Bettin, Irena B. Cabrera Md, Adetola Louis-Jacques Md, Amy M. Ahnert Md, Ronald S. Freudenberger Md

Ronald S Freudenberger MD

No abstract provided.


Length Of The Second Stage Of Labor And Risk Of Preterm Delivery In A Subsequent Pregnancy, Joanne Quiñones MD, MSCE, Daniel Gomez MD, Matthew Hoffman MD, Cande V. Ananth PhD, John C. Smulian MD, MPH, Lauren A. Plante MD, Daniel W. Skupsk MD, Karin M. Fuchs MD, William E. Scorza MD 2016 Lehigh Valley Health Network

Length Of The Second Stage Of Labor And Risk Of Preterm Delivery In A Subsequent Pregnancy, Joanne Quiñones Md, Msce, Daniel Gomez Md, Matthew Hoffman Md, Cande V. Ananth Phd, John C. Smulian Md, Mph, Lauren A. Plante Md, Daniel W. Skupsk Md, Karin M. Fuchs Md, William E. Scorza Md

John C Smulian MD, MPH

No abstract provided.


P66shc, A Key Regulator Of Metabolism And Mitochondrial Ros Production, Is Dysregulated By Mouse Embryo Culture., Nicole A Edwards, Andrew J Watson, Dean H Betts 2016 Western University

P66shc, A Key Regulator Of Metabolism And Mitochondrial Ros Production, Is Dysregulated By Mouse Embryo Culture., Nicole A Edwards, Andrew J Watson, Dean H Betts

Obstetrics and Gynaecology Publications

STUDY QUESTION: Do high oxygen tension and high glucose concentrations dysregulate p66Shc (Src homologous-collagen homologue adaptor protein) expression during mouse preimplantation embryo culture?

SUMMARY ANSWER: Compared with mouse blastocysts in vivo, P66Shc mRNA and protein levels in blastocysts maintained in vitro increased under high oxygen tension (21%), but not high glucose concentration.

WHAT IS KNOWN ALREADY: Growth in culture adversely impacts preimplantation embryo development and alters the expression levels of the oxidative stress adaptor protein p66Shc, but it is not known if p66Shc expression is linked to metabolic changes observed in cultured embryos.

STUDY DESIGN, SAMPLES/MATERIALS, METHODS: We used ...


Caesarean Section Surgical Techniques: All Equally Safe, Marleen Temmerman 2016 Aga Khan University

Caesarean Section Surgical Techniques: All Equally Safe, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Since 1985, a caesarean section rate of 10–15% has been deemed optimum by the international health-care community.1 When caesarean section rates rise towards 10% across a population, maternal and newborn deaths decrease; when they are higher than 15%, there is no evidence of reduced mortality.1 Complications of caesarean sections can be substantial and sometimes permanent for both mothers and babies, and can result in disability or death, especially in settings with inadequate facilities or capacity to undertake safe surgery and treat surgical complications.


Characterization Of Babies Discharged From Cabell Huntington Hospital During The Calendar Year 2005 With The Diagnoses Of Neonatal Abstinence Syndrome, F. Ross Baxter MD, Robert Nerhood MD, David Chaffin MD 2016 Marshall University

Characterization Of Babies Discharged From Cabell Huntington Hospital During The Calendar Year 2005 With The Diagnoses Of Neonatal Abstinence Syndrome, F. Ross Baxter Md, Robert Nerhood Md, David Chaffin Md

David G. Chaffin

Recent concern regarding the impact of maternal drug abuse on neonatal well-being was the impetus for this retrospective cohort study of newborns diagnosed with neonatal abstinence syndrome that were discharged from Cabell Huntington Hospital during the calendar year 2005. Medical records of the neonates and their mothers were analyzed for a variety of health related outcomes and healthcare cost. Forty-eight neonates were diagnosed with Neonatal Abstinence Syndrome in 2005, forty of which required NICU assistance. The average maternal age at delivery was 26; gravity was 3.1 and most were single, separated or divorced. The majority had poor or inconsistent ...


Recruitment Feasibility Study For Reducing Postpartum Smoking Among Low-Income And Hispanic Women, Helai Hesham MD, Sandra L. Curet MD, Suresh G. Nair MD, Hope Kincaid MPH, CPH, Cynthia Beitler, Lourdes T. Matos, Clare Lenhart PhD, MPH 2016 Lehigh Valley Health Network

Recruitment Feasibility Study For Reducing Postpartum Smoking Among Low-Income And Hispanic Women, Helai Hesham Md, Sandra L. Curet Md, Suresh G. Nair Md, Hope Kincaid Mph, Cph, Cynthia Beitler, Lourdes T. Matos, Clare Lenhart Phd, Mph

Suresh G. Nair MD

No abstract provided.


Two Patients With Germline Mutations In Both Brca1 And Brca2 Discovered Unintentionally: A Case Series And Discussion Of Brca Testing Modalities, Ann Marie Augustyn, Nicole M. Agostino DO, Tara Namey, Suresh G. Nair MD, Martin A. Martino MD 2016 Lehigh Valley Health Network

Two Patients With Germline Mutations In Both Brca1 And Brca2 Discovered Unintentionally: A Case Series And Discussion Of Brca Testing Modalities, Ann Marie Augustyn, Nicole M. Agostino Do, Tara Namey, Suresh G. Nair Md, Martin A. Martino Md

Suresh G. Nair MD

No abstract provided.


Urethral Solitary Fibrous Tumor: A Rare Pathologic Diagnosis Of A Periurethral Mass, Gaby N. Moawad, Elias Abi Khalil, Cheryl Silverbrook, Stephanie Barak, Alice Semerjian, Michael Phillips 2016 George Washington University

Urethral Solitary Fibrous Tumor: A Rare Pathologic Diagnosis Of A Periurethral Mass, Gaby N. Moawad, Elias Abi Khalil, Cheryl Silverbrook, Stephanie Barak, Alice Semerjian, Michael Phillips

Obstetrics and Gynecology Faculty Publications

Solitary fibrous tumors (SFTs) may occur at any site in the body. SFTs can only be conclusively diagnosed based on histopathologic and immunohistochemical characteristics of the tumor. The presence of SFTs in the abdomen and pelvis is extremely rare. To our knowledge no cases of urethral solitary fibrous tumor in the literature have been reported so far. We present a case of a solitary fibrous tumor arising from the urethra in a twenty-three-year-old female presenting with vaginal mass.


Model Assessment And Development Of Risk Stratification Of Surgical Site Infection Following Cesarean Delivery For A High-Risk, Urban Population, Dakisha N. Lewis, Nicole P. Salvo, Kiley A. Bernhard, Danielle M. Greer 2016 Department of Obstetrics and Gynecology, Aurora Sinai Medical Center

Model Assessment And Development Of Risk Stratification Of Surgical Site Infection Following Cesarean Delivery For A High-Risk, Urban Population, Dakisha N. Lewis, Nicole P. Salvo, Kiley A. Bernhard, Danielle M. Greer

Nicole P. Salvo, MD

Background: Surgical site infection (SSI) remains a major cause of morbidity despite efforts aimed at prevention and treatment. Risk stratification tools identify patients at greatest risk of SSI. Two models of stratification are: 1) the Centers for Disease Control and Prevention’s National Healthcare Safety Network SSI Risk Index (NHSN), which assigns risk based on surgery duration, surgical wound contamination and physical status; and 2) the New Risk Stratification Schema (NRSS). The NRSS aimed to improve upon NHSN by incorporating five variables: diabetes control, body mass index (BMI), chorioamnionitis, methods of placental extraction and skin closure.

Purpose: Our objectives were ...


Model Assessment And Development Of Risk Stratification Of Surgical Site Infection Following Cesarean Delivery For A High-Risk, Urban Population, Dakisha N. Lewis, Nicole P. Salvo, Kiley A. Bernhard, Danielle M. Greer 2016 Department of Obstetrics and Gynecology, Aurora Sinai Medical Center

Model Assessment And Development Of Risk Stratification Of Surgical Site Infection Following Cesarean Delivery For A High-Risk, Urban Population, Dakisha N. Lewis, Nicole P. Salvo, Kiley A. Bernhard, Danielle M. Greer

Nicole Salvo, MD

Background: Surgical site infection (SSI) remains a major cause of morbidity despite efforts aimed at prevention and treatment. Risk stratification tools identify patients at greatest risk of SSI. Two models of stratification are: 1) the Centers for Disease Control and Prevention’s National Healthcare Safety Network SSI Risk Index (NHSN), which assigns risk based on surgery duration, surgical wound contamination and physical status; and 2) the New Risk Stratification Schema (NRSS). The NRSS aimed to improve upon NHSN by incorporating five variables: diabetes control, body mass index (BMI), chorioamnionitis, methods of placental extraction and skin closure.

Purpose: Our objectives were ...


A Pilot Study To Assess The Feasibility, Safety And Acceptability Of Soy-Based Diet For Pregnant Women At High Risk For Gestational Diabetes Mellitus, Ling Shi, Vidya Iyer, Emily Jones, Tiffany A. Moore Simas, Alice H. Lichtenstein, Laura L. Hayman 2016 University of Massachusetts Boston

A Pilot Study To Assess The Feasibility, Safety And Acceptability Of Soy-Based Diet For Pregnant Women At High Risk For Gestational Diabetes Mellitus, Ling Shi, Vidya Iyer, Emily Jones, Tiffany A. Moore Simas, Alice H. Lichtenstein, Laura L. Hayman

UMass Center for Clinical and Translational Science Research Retreat

Background: Diet plays an important role in the prevention and management of gestational diabetes mellitus (GDM). Previous studies suggest that soy protein and isoflavones may have beneficial effects on lipid and glucose metabolism. Little is known regarding the cardiometabolic effects of soy intake during pregnancy. This pilot study assessed the feasibility, safety and acceptability of daily consumption of soy foods during pregnancy in women at high risk for GDM, and participant adherence to their assigned treatment.

Methods: A randomized controlled trial (RCT) was conducted among pregnant women at high risk for GDM. The Soy group were counseled to consume a ...


Association Between First Trimester Pregnancy Associated Plasma Protein–A And The Development Of Gestational Diabetes Mellitus, Aylin Sert, Katherine Leung, Molly E. Waring, Raziel Rojas-Rodriguez, Silvia Corvera, Tiffany A. Moore Simas 2016 University of Massachusetts Medical School

Association Between First Trimester Pregnancy Associated Plasma Protein–A And The Development Of Gestational Diabetes Mellitus, Aylin Sert, Katherine Leung, Molly E. Waring, Raziel Rojas-Rodriguez, Silvia Corvera, Tiffany A. Moore Simas

UMass Center for Clinical and Translational Science Research Retreat

Background: Gestational diabetes (GDM) is a common pregnancy complication with significant cardiometabolic consequences for mothers and offspring. Previous research from our group suggests that adipose tissue IGFBP-5 and its unique metalloprotease PAPP-A (Pregnancy Associated Plasma Protein-A) may play mechanistic roles in GDM development by regulating functional IGF-1 levels and lipid storage and metabolism.

Aim: To examine the relationship between circulating PAPP-A levels and GDM development. We hypothesized that high first trimester PAPP-A levels would be associated with decreased GDM risk.

Methods: A retrospective cohort of women delivering singleton gestations at UMass Memorial Healthcare (2009, 2010, 2014, 2015) was assembled by ...


Effectiveness And Short-Term Safety Of Modified Sodium Hyaluronic Acid-Carboxymethylcellulose At Cesarean Delivery: A Randomized Trial., Daniel G. Kiefer MD, Jolene C Muscat, Jarrett Santorelli, Martin R Chavez, Cande V. Ananth PhD, MPH, John C. Smulian MD, MPH, Anthony M Vintzileos 2016 Lehigh Valley Health Network

Effectiveness And Short-Term Safety Of Modified Sodium Hyaluronic Acid-Carboxymethylcellulose At Cesarean Delivery: A Randomized Trial., Daniel G. Kiefer Md, Jolene C Muscat, Jarrett Santorelli, Martin R Chavez, Cande V. Ananth Phd, Mph, John C. Smulian Md, Mph, Anthony M Vintzileos

John C Smulian MD, MPH

BACKGROUND: The rising cesarean birth rate has drawn attention to risks associated with repeat cesarean birth. Prevention of adhesions with adhesion barriers has been promoted as a way to decrease operative difficulty. However, robust data demonstrating effectiveness of such interventions are lacking.

OBJECTIVE: We report data from a multicenter trial designed to evaluate the short-term safety and effectiveness of a modified sodium hyaluronic acid (HA)-carboxymethylcellulose (CMC) absorbable for reduction of adhesions following cesarean delivery.

STUDY DESIGN: Patients who underwent primary or repeat cesarean delivery were included in this multicenter, single-blinded (patient), randomized controlled trial. Patients were randomized into either ...


Catecholaminergic Polymorphic Ventricular Tachycardia In Pregnancy., Matthew P. Romagano DO, Joanne Quiñones MD, MSCE, Amy M. Ahnert MD, Rafael E. Martinez MD, John C. Smulian MD, MPH 2016 Lehigh Valley Health Network

Catecholaminergic Polymorphic Ventricular Tachycardia In Pregnancy., Matthew P. Romagano Do, Joanne Quiñones Md, Msce, Amy M. Ahnert Md, Rafael E. Martinez Md, John C. Smulian Md, Mph

John C Smulian MD, MPH

BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia is a genetic disorder in which ventricular tachycardia occurs in the absence of structural heart disease or a prolonged QT interval. If untreated, there is a high incidence of sudden cardiac death. Management of this cardiac condition during pregnancy merits a multidisciplinary approach.

CASE: A nulliparous woman with catecholaminergic polymorphic ventricular tachycardia presented at 15 weeks of gestation. Her care involved a multidisciplinary team including cardiology, maternal-fetal medicine, obstetric nursing, cardiac nursing, and anesthesia. A simulation scenario was designed to prepare for cardiac events during labor. A term intrapartum cesarean delivery was performed for fetal ...


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