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Lessons From An Evidence-Based Medicine Exploration: When Transparency And Sensitivity (Analyses) Can Change The Take-Home Message, Nadi N. Kaonga, Toby Fitzgerald 2020 Maine Medical Center

Lessons From An Evidence-Based Medicine Exploration: When Transparency And Sensitivity (Analyses) Can Change The Take-Home Message, Nadi N. Kaonga, Toby Fitzgerald

Journal of Maine Medical Center

No abstract provided.


Strengthening The Evidence Base For Telehealth For Abortion Service Delivery, Nadi Kaonga 2020 Maine Medical Center

Strengthening The Evidence Base For Telehealth For Abortion Service Delivery, Nadi Kaonga

Journal of Maine Medical Center

Telehealth – which is the use of information and communication technology to provide clinical services to patients remotely – provides an opportunity to extend safe abortion services to women. A recent review article on telehealth for abortion service delivery found it to be acceptable, feasible and safe when compared to in-person service delivery. Despite the promising findings, the evidence base can and should be strengthened to optimize the impact of such services for women. Areas for improvement include evaluating the efficacy and effectiveness of telehealth implementations in more remote settings and with women across variable levels of technoliteracy, conducting cost-effectiveness analyses and ...


Evaluation Of Geographic Disparities In Cervical Cancer Survival Across Maine, Kaylee Underkofler, Jason Lachance 2020 University of Rochester Medical Center

Evaluation Of Geographic Disparities In Cervical Cancer Survival Across Maine, Kaylee Underkofler, Jason Lachance

Journal of Maine Medical Center

Introduction. National data exists suggesting the existence of geographic disparities in oncology care within the United States. It is unknown whether geographic disparities present a problem for women with gynecologic malignancies locally in Maine.

Methods. Data for each cervical cancer case diagnosed or treated under the MaineHealth system between 2007 and 2011 were acquired from the MaineHealth Network Registry. Average annual incidence and 5-year survival were calculated for each county in Maine and were mapped using geographic information systems (GIS) software. Next, cases were divided into 2 groups: those residing less than or equal to 60 miles from the sole ...


Perceptions And Experiences Of Men And Women Towards Acceptability And Use Of Contraceptives In Underserved Areas Of Karachi, Pakistan: A Midline Qualitative Assessment Of Sukh Initiative, Karachi Pakistan, Sarah Saleem, Narjis Rizvi, Anam Feroz, Sayyeda Reza, Saleem Jessani, Farina Abrejo 2020 Aga Khan University

Perceptions And Experiences Of Men And Women Towards Acceptability And Use Of Contraceptives In Underserved Areas Of Karachi, Pakistan: A Midline Qualitative Assessment Of Sukh Initiative, Karachi Pakistan, Sarah Saleem, Narjis Rizvi, Anam Feroz, Sayyeda Reza, Saleem Jessani, Farina Abrejo

Community Health Sciences

Background: Family planning (FP) is an essential component of Sustainable Development Goals (SDG) and contributes directly to SDG targets 3.7 and 5.6. In Pakistan, contraceptive use has remained stagnant over the past 5 years. This change has been very slow when compared to the FP2020 pledge. The Sukh initiative project was conceived and implemented to alleviate these challenges by providing access to quality contraceptive methods in some underserved areas of Karachi, Pakistan. A qualitative study was conducted to understand the perceptions and experiences of men and women towards acceptability and contraceptive use.
Methods: A qualitative study was conducted ...


Executive Summary Of The Early-Onset Breast Cancer Evidence Review Conference., David Chelmow, Mark D Pearlman, Amy Young, Laura Bozzuto, Sandra Dayaratna, Myrlene Jeudy, Mallory E Kremer, Dana Marie Scott, Julia Sage OʼHara 2020 Virginia Commonwealth University

Executive Summary Of The Early-Onset Breast Cancer Evidence Review Conference., David Chelmow, Mark D Pearlman, Amy Young, Laura Bozzuto, Sandra Dayaratna, Myrlene Jeudy, Mallory E Kremer, Dana Marie Scott, Julia Sage OʼHara

Department of Obstetrics and Gynecology Faculty Papers

The Centers for Disease Control and Prevention launched the Bring Your Brave campaign to increase knowledge about early-onset breast cancer, defined as breast cancer in women aged 18-45 years. The American College of Obstetricians and Gynecologists convened a panel of experts in breast disease from the Society for Academic Specialists in General Obstetrics and Gynecology to review relevant literature, validated tools, best practices, and practice guidelines as a first step toward developing educational materials for women's health care providers about early-onset breast cancer. Panel members conducted structured literature reviews, which were then reviewed by other panel members and discussed ...


Mesenteric Lymphatic Malformation Mimicking An Adnexal Source In A Teenager, Victoria L. Troesch, Erica M. Carlisle, Sarah A. Shaffer 2020 University of Iowa, Iowa City, Iowa

Mesenteric Lymphatic Malformation Mimicking An Adnexal Source In A Teenager, Victoria L. Troesch, Erica M. Carlisle, Sarah A. Shaffer

POG In Press

Mesenteric lymphatic malformations are rare benign tumors that are usually found in children and very rarely are they found in the abdomen. We present a rare case in which a mesenteric lymphatic malformation mimics an adnexal source. This is an important contribution to obstetrics and gynecology literature to show the importance of keeping this rare diagnosis on the differential, as well as the value of multi-disciplinary care.


Pregnancy Management In A Patient With Stickler Syndrome., Julie Gomez, Stephanie M. Rice, Mona M. Makhamreh, Huda B. Al-Kouatly 2020 Thomas Jefferson University

Pregnancy Management In A Patient With Stickler Syndrome., Julie Gomez, Stephanie M. Rice, Mona M. Makhamreh, Huda B. Al-Kouatly

Department of Obstetrics and Gynecology Faculty Papers

BACKGROUND: Stickler syndrome is a collagen disorder that can affect multiple organ systems. It is characterized by ocular abnormalities, hearing loss, midfacial hypoplasia, hypermobility, and joint abnormalities. The phenotypic expression of Stickler syndrome can vary among those affected. Since Stickler syndrome is a collagen disorder, it is possible to expect pregnancy complications similar to those reported in other collagen disorders. To our knowledge, there is only one case report in the literature on the management of pregnancy and delivery of a patient with Stickler syndrome.

METHODS/CASE REPORT: A 37-year-old primigravid woman with a diagnosis of Stickler syndrome presented at ...


Maternal Inflammatory Bowel Disease, Racial Diversity And Adverse Birth Outcomes, Zubair Saeed, Hany Aly, Charles Macri, Dinan Abdelatif, Mohamed A. Mohamed 2020 Fairfax County Health Department, Fairfax, Virginia

Maternal Inflammatory Bowel Disease, Racial Diversity And Adverse Birth Outcomes, Zubair Saeed, Hany Aly, Charles Macri, Dinan Abdelatif, Mohamed A. Mohamed

POG In Press

Background: Inflammatory bowel disease (IBD) is a term used to describe two conditions, Crohn’s disease and ulcerative colitis (UC), that currently have no definite cure. The incidence of IBD worldwide has increased, frequently affecting women during their reproductive years.

Objectives: This study examines the association of Crohn's disease and ulcerative colitis (UC) with adverse pregnancy outcomes and looks at the interactions of race/ethnicity on these associations.

Study Design: We examined hospital birth records in the National Inpatient Sample (NIS) data sets in 2011 and 2012. We identified maternal demographics and clinical characteristics using international classification of disease-9 ...


Stepwise Implementation Of Vaginal Cleansing And Azithromycin At Cesarean Delivery To Decrease Postoperative Infections; A Quality Improvement Study, Julie Gomez, MS, Johanna Quist-Nelson, MD, Laura Felder, MD, Daniele DiMascio, MD, Rebecca Eckler, MD, Amanda Paternostro, MD, Michael Posencheg, MD, Jason Baxter, MD, Vincenzo Berghella, MD 2020 Thomas Jefferson University

Stepwise Implementation Of Vaginal Cleansing And Azithromycin At Cesarean Delivery To Decrease Postoperative Infections; A Quality Improvement Study, Julie Gomez, Ms, Johanna Quist-Nelson, Md, Laura Felder, Md, Daniele Dimascio, Md, Rebecca Eckler, Md, Amanda Paternostro, Md, Michael Posencheg, Md, Jason Baxter, Md, Vincenzo Berghella, Md

House Staff Quality Improvement and Patient Safety Conference (2020-)

Aims for Improvement

We aimed to decrease our SSI rate by 30% by sequential implementation of vaginal cleaning1,2 and azithromycin3 for women who underwent a CD after having labored or experienced rupture of membranes.


Jefferson Postpartum Oxytocin Protocol Standardization, Julie Gomez, MS, Farnaz Farhi, MD, Sara Hinton, PharmD, Tara Biedrzycki, PharmD, Deborah Cruz, MSN, CRNP, Jason Baxter, MD 2020 Thomas Jefferson University

Jefferson Postpartum Oxytocin Protocol Standardization, Julie Gomez, Ms, Farnaz Farhi, Md, Sara Hinton, Pharmd, Tara Biedrzycki, Pharmd, Deborah Cruz, Msn, Crnp, Jason Baxter, Md

House Staff Quality Improvement and Patient Safety Conference (2020-)

Aims for Improvement

We aimed to reduce the variation and subsequent waste of postpartum oxytocin by standardizing the concentration available across the three maternity hospitals within the hospital enterprise system.


A Web-Based, Positive Emotion Skills Intervention For Enhancing Posttreatment Psychological Well-Being In Young Adult Cancer Survivors (Empower): Protocol For A Single-Arm Feasibility Trial, John M. Salsman, Laurie E. McLouth, Michael Cohn, Janet A. Tooze, Mia Sorkin, Judith T. Moskowitz 2020 Wake Forest University

A Web-Based, Positive Emotion Skills Intervention For Enhancing Posttreatment Psychological Well-Being In Young Adult Cancer Survivors (Empower): Protocol For A Single-Arm Feasibility Trial, John M. Salsman, Laurie E. Mclouth, Michael Cohn, Janet A. Tooze, Mia Sorkin, Judith T. Moskowitz

Behavioral Science Faculty Publications

BACKGROUND: Adolescent and young adult cancer survivors (AYAs) experience clinically significant distress and have limited access to supportive care services. Interventions to enhance psychological well-being have improved positive affect and reduced depression in clinical and healthy populations but have not been routinely tested in AYAs.

OBJECTIVE: The aim of this protocol is to (1) test the feasibility and acceptability of a Web-based positive emotion skills intervention for posttreatment AYAs called Enhancing Management of Psychological Outcomes With Emotion Regulation (EMPOWER) and (2) examine proof of concept for reducing psychological distress and enhancing psychological well-being.

METHODS: The intervention development and testing are ...


Clinical Characteristics Of 46 Pregnant Women With A Sars-Cov-2 Infection In Washington State., Erica M Lokken, Christie L Walker, Shani Delaney, Alisa Kachikis, Nicole M Kretzer, Anne Erickson, Rebecca Resnick, Jeroen Vanderhoeven, Joseph K Hwang, Nena Barnhart, Jasmine Rah, Stephen A Mccartney, Kimberly K Ma, Emily M Huebner, Chad Thomas, Jessica S Sheng, Bettina W Paek, Kristin Retzlaff, Carolyn R Kline, Jeff Munson, Michela Blain, Sylvia M Lacourse, Gail Deutsch, Kristina Adams Waldorf 2020 Swedish Maternal Fetal Specialty Center, Swedish Medical Center, Seattle, Washington

Clinical Characteristics Of 46 Pregnant Women With A Sars-Cov-2 Infection In Washington State., Erica M Lokken, Christie L Walker, Shani Delaney, Alisa Kachikis, Nicole M Kretzer, Anne Erickson, Rebecca Resnick, Jeroen Vanderhoeven, Joseph K Hwang, Nena Barnhart, Jasmine Rah, Stephen A Mccartney, Kimberly K Ma, Emily M Huebner, Chad Thomas, Jessica S Sheng, Bettina W Paek, Kristin Retzlaff, Carolyn R Kline, Jeff Munson, Michela Blain, Sylvia M Lacourse, Gail Deutsch, Kristina Adams Waldorf

Articles, Abstracts, and Reports

BACKGROUND: The impact of the coronavirus disease 2019 (Covid-19) on pregnant women is incompletely understood, but early data from case series suggest a variable course of illness from asymptomatic or mild disease to maternal death. It is unclear whether pregnant women manifest enhanced disease similar to influenza viral infection or whether specific risk factors might predispose to severe disease.

OBJECTIVE: To describe maternal disease and obstetrical outcomes associated with Covid-19 disease in pregnancy to rapidly inform clinical care.

STUDY DESIGN: Retrospective study of pregnant patients with a laboratory-confirmed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection from six hospital systems in ...


Adverse Childhood Experiences And Changing Levels Of Psychosocial Distress Scores Across Pregnancy In Kenyan Women, Pauline Samia, Shahirose Premji, Farideh Tavangar, Ilona S. Yim, Sikolia Wanyonyi, Mohamoud Merali, Wangira Musana, Geoffrey Omuse, Ntonghanwah Forcheh, Aliyah Dosani, Nicole Letourneau, The Maternal Infant Global Health Team (MiGHT) Collaborators in Research 2020 Aga Khan University

Adverse Childhood Experiences And Changing Levels Of Psychosocial Distress Scores Across Pregnancy In Kenyan Women, Pauline Samia, Shahirose Premji, Farideh Tavangar, Ilona S. Yim, Sikolia Wanyonyi, Mohamoud Merali, Wangira Musana, Geoffrey Omuse, Ntonghanwah Forcheh, Aliyah Dosani, Nicole Letourneau, The Maternal Infant Global Health Team (Might) Collaborators In Research

Paediatrics and Child Health, East Africa

Background: Adverse childhood experiences (ACEs) have been associated with deleterious effects on mental health in pregnancy.

Methods: The ACE International Questionnaire (ACE-IQ) was used to measure neglect, abuse, and household dysfunction. Longitudinal mixed effect modelling was used to test the effect of ACEs on pregnancy-related anxiety, depressive symptoms, and perceived stress at two time points (12–19 and 22–29 weeks) during pregnancy.

Results: A total of 215 women who were predominantly married (81%) and had attained tertiary education (96%) were enrolled. Total ACEs were significantly associated with depressive symptoms (r = 0.23, p < 0.05) and perceived stress (r = 0.18, p < 0.05). As depressive symptoms decreased, t (167) = −8.44, p < 0.001, perceived stress increased, t (167) = 4.60, p < 0.001, and pregnancy-related anxiety remained unchanged as pregnancy progressed. Contact sexual abuse (p < 0.01) and parental death or divorce (p = 0.01) were significantly associated with depression over time (p < 0.01). Total ACEs in this study were associated with depressive symptoms early but not late in pregnancy.

Conclusions: Higher total ACEs were positively ...


Maternal Inflammatory Markers For Chorioamnionitis In Preterm Prelabour Rupture Of Membranes: A Systematic Review And Meta-Analysis Of Diagnostic Test Accuracy Studies, Angela Koech, Geoffrey Omuse, Abraham Mukaindo, Marleen Temmerman 2020 Aga Khan University

Maternal Inflammatory Markers For Chorioamnionitis In Preterm Prelabour Rupture Of Membranes: A Systematic Review And Meta-Analysis Of Diagnostic Test Accuracy Studies, Angela Koech, Geoffrey Omuse, Abraham Mukaindo, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Background: There is no consensus on the role of inflammatory markers in identifying chorioamnionitis in preterm prelabour rupture of membranes (PPROM). We set out to evaluate the accuracy of maternal blood C-reactive protein (CRP), procalcitonin and interleukin 6 (IL6) in diagnosis of histological chorioamnionitis and/or funisitis (HCA/Funisitis) in PPROM.

Methods: We searched MEDLINE, EMBASE and The Cochrane Library from inception to January 2020 for studies where maternal blood CRP, procalcitonin or IL6 was assessed against a reference standard of HCA/Funisitis in PPROM. The Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool was used to assess methodological ...


An Examination Of The Association Between State Medicaid Perinatal Services And Birth Outcomes, Joy Morgan Myers 2020 University of Mississippi

An Examination Of The Association Between State Medicaid Perinatal Services And Birth Outcomes, Joy Morgan Myers

Honors Theses

This thesis investigated the connection between socioeconomic status, healthcare coverage, and birth outcomes. The research question that was posed specifically looked at twenty perinatal services that states covered under Medicaid to varying degrees to see their association, if any, with premature birth rates and low birthweight rates. State-level and Mississippi county-level data were compiled regarding preterm birth rates, low birthweight rates, presumptive eligibility adoption, and coverage of twenty different perinatal services. Using these data, the correlation between state Medicaid expansion status and birth outcomes was first calculated in order to determine if variation in birth outcomes was associated with expanded ...


Socioeconomic Status And Symptoms Of Anxiety And Depression In Pregnant Women, Meagan Mandabach 2020 University of Mississippi

Socioeconomic Status And Symptoms Of Anxiety And Depression In Pregnant Women, Meagan Mandabach

Honors Theses

Pregnancy is a period of great change in a woman’s body as her baby develops. During this period, women commonly experience symptoms of anxiety (Dennis et al., 2017) and depression (Shidhaye & Giri, 2014). Literature has suggested that socioeconomic status (SES) can contribute to the severity at which pregnant women experience anxiety and depression (Arora & Aeri, 2019; Field et al., 2008; Shagufta & Shams, 2019), and women of low socioeconomic status may be more likely to experience symptoms of anxiety and depression during pregnancy (Field et al., 2008). The present study aimed to assess the relationships between household income and experience of anxiety and depression symptoms, in pregnant women in Mississippi. Specifically, it was hypothesized that lower SES would be associated with increased experience of anxiety and depressive symptoms. Participants included 557 pregnant women (77.4% white; Mage = 28.42) recruited at an OBGYN clinic in north Mississippi. Demographics questionnaire and several self-report measures including the Depression Anxiety Stress Scale-21 (DASS-21; Lovibond & Lovibond, 1995) and the Edinburgh Postnatal Depression Scale (EPDS; Cox, Holden, Sagovsky, 1987) were completed. Results demonstrated that symptoms of anxiety measured by the DASS-21 were significantly higher in pregnant women earning less than $10,000 per year than all other income brackets (with the exception ...


Ccne1 Amplification As A Predictive Biomarker Of Chemotherapy Resistance In Epithelial Ovarian Cancer, Justin W. Gorski, Frederick R. Ueland, Jill M. Kolesar 2020 University of Kentucky

Ccne1 Amplification As A Predictive Biomarker Of Chemotherapy Resistance In Epithelial Ovarian Cancer, Justin W. Gorski, Frederick R. Ueland, Jill M. Kolesar

Obstetrics and Gynecology Faculty Publications

Ovarian cancer is the most-deadly gynecologic malignancy, with greater than 14,000 women expected to succumb to the disease this year in the United States alone. In the front-line setting, patients are treated with a platinum and taxane doublet. Although 40-60% of patients achieve complete clinical response to first-line chemotherapy, 25% are inherently platinum-resistant or refractory with a median overall survival of about one year. More than 80% of women afflicted with ovarian cancer will recur. Many attempts have been made to understand the mechanism of platinum and taxane based chemotherapy resistance. However, despite decades of research, few predictive markers ...


Successful Non-Surgical Management Of Acute, Uncomplicated Appendicitis In Pregnancy: A Case Report, Avanthi Ajjarapu, Nina N. Moreira 2020 University of Iowa Carver College of Medicine, Iowa City, Iowa

Successful Non-Surgical Management Of Acute, Uncomplicated Appendicitis In Pregnancy: A Case Report, Avanthi Ajjarapu, Nina N. Moreira

Proceedings in Obstetrics and Gynecology

Acute appendicitis during pregnancy is one of the most common non-obstetric indications for surgery during pregnancy. Prompt surgical intervention for appendicitis is considered the standard of care. However, data on the utility of surgical management of uncomplicated cases of appendicitis is inconclusive and effectiveness of non-surgical management is currently understudied. We present a case that provides evidence for successful, antibiotic management of uncomplicated appendicitis as a means to reduce the burden of surgical complications on the pregnant population. This article also offers a critical analysis of current standard of care and assesses feasibility of nonsurgical management of acute, uncomplicated appendicitis ...


Health Care Disparities: Moving The Needle, Marygrace Elson 2020 University of Iowa, Iowa City, Iowa

Health Care Disparities: Moving The Needle, Marygrace Elson

Proceedings in Obstetrics and Gynecology

As an obstetrician, I am acutely aware of the United States maternal mortality rate, which is frighteningly worse than any other developed country. Even more alarming is the fact that the rate for black and native women in the USA is 3-4 times higher, regardless of socioeconomic status and education level. In Iowa, our maternal mortality figures are no better than the rest of the nation overall and may be slightly worse for black and native women. How can this be, when Iowa enjoys a reputation for quality health care?


Reflections On North Texas Ob-Gyn Internship, Catherine Beachner 2020 University of Arkansas, Fayetteville

Reflections On North Texas Ob-Gyn Internship, Catherine Beachner

The Eleanor Mann School of Nursing Undergraduate Honors Theses

This thesis provides a personal reflection on a nurse internship with North Texas Ob-Gyn Associations located in Lewisville, Texas. An evaluation of the internship was conducted by providing a description of the position, analyzing the internship, and outlining a pertinent patient case study. The responsibilities for this position mainly included assisting the doctor during appointments. An extensive range of skills were gained through the experience, including developing confidence in interactions with patients and learning physical tasks. The focus of the honors project was overall learning, which occurred through completion of learning goals, and the goals of the internship were fully ...


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