University of New England
Aga Khan University
University of North Florida
University of Massachusetts Medical School
The Corticosteroid Compounds Prednisolone And Vamorolone Do Not Alter The Nociception Phenotype And Exacerbate Liver Injury In Sickle Cell Mice.,
2018
George Washington University
The Corticosteroid Compounds Prednisolone And Vamorolone Do Not Alter The Nociception Phenotype And Exacerbate Liver Injury In Sickle Cell Mice., Luis E F Almeida, Jesse M Damsker, Sarah Albani, Nina Afsar, Sayuri Kamimura, Drew Pratt, David E Kleiner, Martha Quezado, Heather Gordish-Dressman, Zenaide M N Quezado
Anesthesiology and Critical Care Medicine Faculty Publications
Clinicians often hesitate prescribing corticosteroids to treat corticosteroid-responsive conditions in sickle cell disease (SCD) patients because their use can be associated with complications (increased hospital readmission, rebound pain, strokes, avascular necrosis, acute chest syndrome). Consequently, SCD patients may receive suboptimal treatment for corticosteroid-responsive conditions. We conducted a preclinical trial of dissociative (vamorolone) and conventional (prednisolone) corticosteroid compounds to evaluate their effects on nociception phenotype, inflammation, and organ dysfunction in SCD mice. Prednisolone and vamorolone had no significant effects on nociception phenotype or anemia in homozygous mice. Conversely, prednisolone and vamorolone significantly decreased white blood cell counts and hepatic inflammation. Interestingly ...
Refrigerated Stability Of Diluted Cisatracurium, Rocuronium, And Vecuronium For Skin Testing After Perioperative Anaphylaxis,
2018
East Tennessee State University
Refrigerated Stability Of Diluted Cisatracurium, Rocuronium, And Vecuronium For Skin Testing After Perioperative Anaphylaxis, Kristen Dinsmore, Bethany Campbell, Timothy Archibald, Greg Mosier, Stacy Brown Phd, Alexei Gonzalez-Estrada Md
Appalachian Student Research Forum
Rationale: The purpose of this study is to investigate the stored stability of dilutions of neuromuscular blocking agents (NMBAs), namely cisatracurium, rocuronium, and vecuronium, for skin prick/intradermal testing.
Methods: Concentrations of NMBAs were monitored by liquid chromatography-mass spectrometry (LC-MS/MS) for a period of 14 days. Dilutions of NMBAs were prepared in saline by factors of 10x, 100x, 1,000x, 10,000x, and 100,000x as sensitivity of the assay allowed. Diluted drug products were stored in a laboratory refrigerator until sampling. On sampling days, aliquots of each dilution were removed and compared to a freshly prepared set of ...
Manual De Crisis En Neuroanestesia,
2018
Western University
Manual De Crisis En Neuroanestesia, Angela Builes
Anesthesia & Perioperative Medicine Publications
El propósito de este manual de crisis es convertirse en un recurso para los
anestesiólogos, prepararlos para situaciones estresantes que puedan surgir
durante procedimientos neuroquirúrgicos. Está diseñado para servir de
referencia y ayuda cognitiva en situaciones de emergencia. NO es una guía o
protocolo que los anestesiólogos están obligados a seguir. Este manual puede
brindarle ideas y estrategias prácticas cuando se enfrentan a eventos críticos
con pacientes neuroquirúrgicos
Occupational Exposure To Hiv In A Developing Country: Assessing Knowledge And Attitude Of Healthcare Professional Before And After An Awareness Symposium,
2018
Aga Khan University
Occupational Exposure To Hiv In A Developing Country: Assessing Knowledge And Attitude Of Healthcare Professional Before And After An Awareness Symposium, Samina Ismail, Safia Awan, Rubaba Naeem, Sarfraz Siddiqui, Badar Afzal, Bushra Jamil, Uzma Rahim Khan2 Uzma Rahim Khan2 Uzma Rahim Khan2
Department of Anaesthesia
Objective:
Health care providers (HCPs) are at risk of occupational exposure to HIV infection. In developing world these exposure occur due to general lack of awareness, education and structured training of HCPs. The objective of the study was to asses if continuing medical education symposium can be used as an effective educational tool to improve attitude, awareness and knowledge regarding occupational exposure to HIV infection. This quasi-experimental study was conducted among HCPs from Karachi, Pakistan. After assessing the baseline knowledge, awareness, and attitude by means of pretest; HCPs were reassessed with posttest after an education symposium on occupational exposure to ...
Occupational Exposure To Hiv In A Developing Country: Assessing Knowledge And Attitude Of Healthcare Professional Before And After An Awareness Symposium,
2018
Aga Khan University
Occupational Exposure To Hiv In A Developing Country: Assessing Knowledge And Attitude Of Healthcare Professional Before And After An Awareness Symposium, Samina Ismail, Safia Awan, Rubaba Naeem, Sarfraz Siddiqui, Badar Afzal, Bushra Jamil, Uzma Rahim Khan
Department of Anaesthesia
Objective:
Health care providers (HCPs) are at risk of occupational exposure to HIV infection. In developing world these exposure occur due to general lack of awareness, education and structured training of HCPs. The objective of the study was to asses if continuing medical education symposium can be used as an effective educational tool to improve attitude, awareness and knowledge regarding occupational exposure to HIV infection. This quasi-experimental study was conducted among HCPs from Karachi, Pakistan. After assessing the baseline knowledge, awareness, and attitude by means of pretest; HCPs were reassessed with posttest after an education symposium on occupational exposure to ...
Haemodynamic Assessment And Support In Sepsis And Septic Shock In Resource-Limited Settings,
2018
Aga Khan University
Haemodynamic Assessment And Support In Sepsis And Septic Shock In Resource-Limited Settings, David Misango, Rajyabardhan Pattnaik, Tim Baker, Martin W. Dünser, Arjen M. Dondorp, Marcus J. Schultz, Global Intensive Care Working Group†, Of The European Society Of Intensive Care Medicine (Esicm) And The Mahidol Oxford Tropical Medicine Research Unit (Moru) In Bangkok, Thailand
Anaesthesiology, East Africa
Background: Recommendations for haemodynamic assessment and support in sepsis and septic shock in resource-limited settings are largely lacking.
Methods: A task force of six international experts in critical care medicine, all of them members of the Global Intensive Care Working Group of the European Society of Intensive Care Medicine and with extensive bedside experience in resource-limited intensive care units, reviewed the literature and provided recommendations regarding haemodynamic assessment and support, keeping aspects of efficacy and effectiveness, availability and feasibility and affordability and safety in mind.
Results: We suggest using capillary refill time, skin mottling scores and skin temperature gradients; suggest ...
Bladder Distension As A Cause Of Abdominal Compartment Syndrome,
2018
Security Forces Hospital, Riyadh, Saudi Arab
Bladder Distension As A Cause Of Abdominal Compartment Syndrome, Muhammad Yasir, Muhammad Qamarul Hoda, Tauseef Ahmed
Department of Anaesthesia
Abdominal compartment syndrome (ACS) is increasingly identified in critically ill patient and its harmful effects are well documented. The disparity among the pressure, volume in abdominal cavity and its contents, results in ACS. The actual incidence of ACS is not known. However, it has been observed predominantly in patients with severe blunt and penetrating abdominal trauma, ruptured abdominal aortic aneurysms, retro- and intra-peritoneal hemorrhage, pneumoperitoneum, neoplasm, pancreatitis, ascites and multiple bone fracture. We present a case of 40-year female who underwent emergency cesarean section and developed abdominal compartment syndrome due to urinary bladder distension secondary to blockade of urinary catheter ...
Systematic In Vivo Evaluation Of The Time-Dependent Inflammatory Response To Steel And Teflon Insulin Infusion Catheters.,
2018
Medical University of Graz
Systematic In Vivo Evaluation Of The Time-Dependent Inflammatory Response To Steel And Teflon Insulin Infusion Catheters., Jasmin R. Hauzenberger, Julia Münzker, Petra Kotzbeck, Martin Asslaber, Vladimir Bubalo, Jeffrey I. Joseph, Thomas R. Pieber
Department of Anesthesiology Faculty Papers
Continuous subcutaneous insulin infusion (CSII) catheters are considered the weak link of insulin pump therapy. Wear-time considerably varies between patients and the choice of catheter material is based on personal preferences rather than scientific facts. Therefore, we systematically assessed and quantified the inflammatory tissue response to steel versus Teflon CSII catheters over a maximum wear-time of 7 days in swine. Tissue surrounding catheters was analysed using histopathology and quantitative real-time PCR. The area of inflammation increased significantly over time independent of material which was confirmed by an increase in CD68 expression and an increase in mononuclear and neutrophil cell infiltrate ...
Analgesic Effect Of Bilateral Subcostal Tap Block After Laparoscopic Cholecys Tectomy,
2018
Aga Khan University
Analgesic Effect Of Bilateral Subcostal Tap Block After Laparoscopic Cholecys Tectomy, Karima Karam Khan, Robyna Irshad Khan
Department of Anaesthesia
Background: Pain after laparoscopic cholecystectomy is mild to moderate in intensity. Several modalities are employed for achieving safe and effective postoperative analgesia, the benefits of which adds to the early recovery of the patients. As a part of multimodal analgesia, various approaches of Transversus abdominis plane (TAP) block has been used for management of parietal and incisional components of pain after laparoscopic cholecystectomy. This study was designed to compare the analgesic efficacy of two different approaches of ultrasound guided TAP block, i.e., Subcostal-TAP block technique with ultrasound guided Posterior-TAP block for postoperative pain management in patients undergoing laparoscopic cholecystectomy ...
Use Of Caudal Epidural Catheter In A Child With Cerebral Palsy With Prior Posterior Spine (T1-Sacrum) Fusion.,
2018
Thomas Jefferson University; Nemours/Alfred I. duPont Hospital for Children
Use Of Caudal Epidural Catheter In A Child With Cerebral Palsy With Prior Posterior Spine (T1-Sacrum) Fusion., Divya Dixit, Mary C. Theroux, Kirk W. Dabney, Freeman Miller
Department of Anesthesiology Faculty Papers
No abstract provided.
Is Homocystinuria A Real Challenge For Anesthetist? Are We Making A Difference?,
2018
Aga Khan University
Is Homocystinuria A Real Challenge For Anesthetist? Are We Making A Difference?, Muhammad Umar Slote, Karima Karam Khan,, Ausaf Ahmed Khan, Mohsin Nazir Butt
Department of Anaesthesia
No abstract provided.
A Reliable Alternative Of Fiberoptic Bronchoscope Inunanticipated Difficult Airway: Flexible Fiberoptic Cystoscope,
2018
Aga Khan University
A Reliable Alternative Of Fiberoptic Bronchoscope Inunanticipated Difficult Airway: Flexible Fiberoptic Cystoscope, Muhammad Sohaib, Khalid Maudood Siddiqui, Muhammad Faisal Khan
Department of Anaesthesia
No abstract provided.
Neuroanesthesia Crisis Manual,
2018
Western University
Neuroanesthesia Crisis Manual, Angela Builes
Anesthesia & Perioperative Medicine Publications
The purpose of this crisis manual is to be a resource for anesthesiologists and to prepare them for stressful situations that may arise during neurosurgical procedures. It is meant to be a reference only and a cognitive aid in emergency situations. It is NOT a guideline or a protocol that anesthesiologists are obligated to follow. This manual may provide a vehicle for input and practical strategies when facing critical events with neurosurgical patients
Intravenous Lidocaine And Postextubation Laryngospasm,
2018
Aga Khan University
Intravenous Lidocaine And Postextubation Laryngospasm, Muhammad Faisal Khan, Ullah Saleem
Department of Anaesthesia
No abstract provided.
Fluid Choice During Perioperative Care In Children: A Survey Of Present‑Day Proposing Practice By Anesthesiologists In A Intertiary Care Hospital,
2018
Aga Khan University
Fluid Choice During Perioperative Care In Children: A Survey Of Present‑Day Proposing Practice By Anesthesiologists In A Intertiary Care Hospital, Muhammad Faisal Khan, Khalid Maudood Siddiqui, Ali Asghar
Department of Anaesthesia
Background: Perioperative fluid therapy in pediatrics has always been a challenging avenue for anesthesiologists.
Inappropriate choice of fluid leads to multiple side effects, for instance iatrogenic hyponatremia. Our aim was to observe the
current practice of perioperative fluid therapy in pediatric population undergoing surgery in a tertiary care hospital.
Methods: After obtaining approval from the Departmental Research Review Committee, a survey form including questions
was emailed to anesthesiologists from January 2015 to June 2015. Individual responses were recorded and analyzed.
Results: Overall response was 100% from consultant and resident, and total 55 anesthesiologists were participated in
this survey. Majority of ...
Tranexamic Acid (Txa) To Reduce Bleeding In Paediatric Cyanotic Congenital Heart Disease (Chd) Surgeries,
2018
Aga Khan University
Tranexamic Acid (Txa) To Reduce Bleeding In Paediatric Cyanotic Congenital Heart Disease (Chd) Surgeries, Faisal Junejo, Mohammad Irfan Akhtar, Mohammad Hamid, Syed Shabbir Ahmed, Fauzia Minai, Muneer Amanullah
Department of Anaesthesia
Objective: To compare the intravenous boluses and intravenous continuous infusion of tranexamic acid (TXA) to reduce postoperative bleeding in cyanotic congenital heart disease surgeries. Study Design: Single-blinded randomised clinical trial. Place and Duration of Study: Anaesthesia Department, The Aga Khan University Hospital, Karachi, from July 2016 to April 2017. Methodology: Sixty patients of cyanotic congenital heart disease, undergoing either palliative or corrective surgery involving cardiopulmonary bypass (CPB), were recruited. These 60 patients were divided randomly into two groups. The infusion group received intravenous infusion of TXA at 5 mg/kg/hour while the bolus group received three intravenous boluses of ...
The Relationship Between Central Venous Catheter And Post-Operative Complications In Patients Undergoing Hepatic Resection,
2018
Virginia Commonwealth University
The Relationship Between Central Venous Catheter And Post-Operative Complications In Patients Undergoing Hepatic Resection, David C. O'Connor
Theses and Dissertations
The Relationship Between Central Venous Catheter and Post-operative Complications in Patients Undergoing Hepatic Resection
David C. O’Connor, Ph.D., DNAP, CRNA
A dissertation submitted in partial fulfillment of the requirements for the degree of
Doctor of Philosophy at Virginia Commonwealth University
Virginia Commonwealth University, 2018
Dissertation Chair: Clarence J. Biddle, Ph.D., CRNA
Hepatic resection is indicated for primary and secondary malignancies. Use of a low central venous pressure technique is associated with decreased blood loss in these cases. This technique has evolved; central venous catheters and high dose morphine are no longer used, and patients are extubated earlier ...
Evaluation Of Delivery Methods Of Chemical Dependency And Wellness Education,
2017
The University of Southern Mississippi
Evaluation Of Delivery Methods Of Chemical Dependency And Wellness Education, Marissa Coggin
Doctoral Nursing Capstone Projects
Anesthesia practice is learned in a stressful environment, and these stressors may lead to the students’ development of maladaptive coping mechanisms. Despite significant improvements in our understanding of addiction and our approaches to combat this problem, the risk of substance misuse remains high in nurse anesthesia students. Education and intervention are imperative when taking preventative measures. The purpose of this Doctor of Nursing Practice (DNP) project was to determine whether delivery method of chemical dependency/wellness educational program effects the level of understanding of anesthesia providers and substance misuse and the development of healthy coping mechanisms.
In determining whether the ...
Subanesthetic Ketamine For Postoperative Analgesia: An Evidenced-Based Project,
2017
University of Southern Mississippi
Subanesthetic Ketamine For Postoperative Analgesia: An Evidenced-Based Project, Jeremy Vance
Doctoral Nursing Capstone Projects
Roughly 100 million surgical procedures are performed in the United States (U.S.) each year and more than 80% of these patients experience acute postoperative pain. Pain costs the U.S. an estimated $560 to $635 billion annually and is a significant contributor to national rates of mortality, morbidity, and disability. Despite these findings, patients continue to receive suboptimal postoperative pain relief.
The adjunct administration of subanesthetic ketamine is opioid-sparing and can improve the effectiveness of a multimodal pain management approach. This project used an exploratory descriptive design to examine how an evidence-based presentation impacted the clinical practice of certified ...
Dealing A Neonate With Charge Syndrome: Anaesthesia Perspective Of Perioperative Care,
2017
Aga Khan University
Dealing A Neonate With Charge Syndrome: Anaesthesia Perspective Of Perioperative Care, Khalid M Siddiqui, Muhammad Ali Asghar, Amjad Nadeem
Department of Anaesthesia
CHARGE syndrome is a condition that can disturb numerous areas of human body. As an abbreviation CHARGE stands for: coloboma, heart defects, atresia choanae, and retardation of growth, genital, and ear abnormalities. The configuration of malformations differs among individuals with this disorder, and the various health issues can be life-threatening during infancy and childhood. Affected individuals typically have several main features or a combination of major and minor appearances. Here we are presenting a case report of a neonate with CHARGE syndrome who underwent successful repair of choanal atresia under general anaesthesia with invasive monitoring.
