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Efficacy Of A Mobile Application In A Chronic Kidney Disease Population, Jennifer R. Zamora 2020 Valparaiso University

Efficacy Of A Mobile Application In A Chronic Kidney Disease Population, Jennifer R. Zamora

Evidence-Based Practice Project Reports

Chronic kidney disease (CKD) is associated with high healthcare costs, poor health outcomes and low quality of life (Donald et al., 2018). The US CKD prevalence is 15%, costing Medicare $79 billion in 2016 (United States Renal Data System, 2018). Self-management could reduce CKD burden (Jeddi, Nabovati, and Amirazodi, 2017). Mobile technology offers a low-cost, ease-of-access platform for chronic disease self-management (Whitehead & Seaton, 2016), potentially slowing disease progression and improving health outcomes (Jeddi, 2017). The purpose of this project was to utilize a CKD-specific mobile application, CARELogiQ, to facilitate symptom management; increasing patient satisfaction and decreasing hospitalizations and ER visits over three months. A five-database literature review yielded six high-quality articles; three level I, two level II, and one level III evidence based on JHNEBP (Dang & Dearholt, 2017). Evidence ...


A Pilot Study On The Feasibility Of A Smartphone Application For Identifying Living Donors For Kidney Transplant Waitlisted Candidates, Shelby McDonnell, Theresa Boulos, Juan Palma, Ana Rossi 2020 Maine Medical Center

A Pilot Study On The Feasibility Of A Smartphone Application For Identifying Living Donors For Kidney Transplant Waitlisted Candidates, Shelby Mcdonnell, Theresa Boulos, Juan Palma, Ana Rossi

Costas T. Lambrew Research Retreat 2020

Purpose: To assess the feasibility of using a smartphone application for potential living donor outreach in patients waitlisted for a kidney transplant in Maine.

Background: More than 100,000 individuals are awaiting organ transplant in the US. For patients needing a kidney transplant, living donation is a way to help meet this need. Barriers to identifying a potential donor include lack of education and hesitance to initiate a conversation about live donation. Social media has been used to assist candidates in finding living donors for over twenty years and can provide a free platform for outreach that can reduce disparities ...


Evaluation Of A Perioperative Anticoagulation Protocol In Renal Transplantation: A Retrospective Analysis., Sierra Ferreira, Brian Carlone, Marizela Savic 2020 Maine Medical Center

Evaluation Of A Perioperative Anticoagulation Protocol In Renal Transplantation: A Retrospective Analysis., Sierra Ferreira, Brian Carlone, Marizela Savic

Costas T. Lambrew Research Retreat 2020

Perioperative anticoagulation is standard for different surgical procedures in order to minimize the risk of thrombotic events. During renal transplantation, disturbances in hemostasis increase the likelihood for both thrombotic and hemorrhagic complications. This is detrimental to consider when balancing the prevention of thromboembolism including graft loss as well as major bleeding. In light of the literature lacking standardization, a perioperative anticoagulation protocol in renal transplantation was implemented at our institution in 2013. The primary purpose of this study is to determine the efficacy of the implemented protocol and further establish anticoagulation practices in the perioperative stage of renal transplantation. This ...


The Implementation Of Exercise For Chronic Kidney Disease And Dialysis Patients, Syed Ahmad Rizvi 2020 Wayne State University Division of Kinesiology, Health and Sport Studies & Honors College

The Implementation Of Exercise For Chronic Kidney Disease And Dialysis Patients, Syed Ahmad Rizvi

Honors College Theses

While commonly known to be the organ that helps with urine production within the human body, the kidney plays one of the most crucial roles in maintaining homeostasis. When establishing all of the roles the kidney has on keeping humans healthy, there is the question of how does the body cope when a patient is diagnosed with kidney failure. One of the more common treatment options that allows the body to continue to function without a kidney is by beginning a patient on a form of dialysis. However, as with any treatment, there will always be a list of side ...


Urinary Epidermal Growth Factor As A Marker Of Disease Progression In Children With Nephrotic Syndrome., Debbie S Gipson, Howard Trachtman, Anne Waldo, Keisha L Gibson, Sean Eddy, Katherine M Dell, Tarak Srivastava, Kevin V Lemley, Larry A Greenbaum, Sangeeta Hingorani, Kevin E Meyers, Frederick J Kaskel, Kimberly J Reidy, Christine B Sethna, Cheryl L Tran, Chia-Shi Wang, Katherine Tuttle, Gia Oh, Alicia M Neu, Elizabeth Brown, Jen-Jar Lin, Jennifer Lai Yee, Therese M Roth, Jonathan P Troost, Brenda W Gillespie, Matthew G Sampson, Matthias Kretzler, Wenjun Ju 2020 Providence St. Joseph Health, Providence Medical Research Center, Spokane, Washington, USA.

Urinary Epidermal Growth Factor As A Marker Of Disease Progression In Children With Nephrotic Syndrome., Debbie S Gipson, Howard Trachtman, Anne Waldo, Keisha L Gibson, Sean Eddy, Katherine M Dell, Tarak Srivastava, Kevin V Lemley, Larry A Greenbaum, Sangeeta Hingorani, Kevin E Meyers, Frederick J Kaskel, Kimberly J Reidy, Christine B Sethna, Cheryl L Tran, Chia-Shi Wang, Katherine Tuttle, Gia Oh, Alicia M Neu, Elizabeth Brown, Jen-Jar Lin, Jennifer Lai Yee, Therese M Roth, Jonathan P Troost, Brenda W Gillespie, Matthew G Sampson, Matthias Kretzler, Wenjun Ju

Articles, Abstracts, and Reports

Introduction: Childhood-onset nephrotic syndrome has a variable clinical course. Improved predictive markers of long-term outcomes in children with nephrotic syndrome are needed. This study tests the association between baseline urinary epidermal growth factor (uEGF) excretion and longitudinal kidney function in children with nephrotic syndrome.

Methods: The study evaluated 191 participants younger than 18 years enrolled in the Nephrotic Syndrome Study Network, including 118 with their first clinically indicated kidney biopsy (68 minimal change disease; 50 focal segmental glomerulosclerosis) and 73 with incident nephrotic syndrome without a biopsy. uEGF was measured at baseline for all participants and normalized by the urine ...


Case Series Of Anca Vasculitis As Prognostic Marker For Severity Or Relapse Of Glomerulonephritis., Jake N. Cho MD, Venkat Chitumalla MD, Izuchukwu Nwakoby MD 2020 HCA Healthcare

Case Series Of Anca Vasculitis As Prognostic Marker For Severity Or Relapse Of Glomerulonephritis., Jake N. Cho Md, Venkat Chitumalla Md, Izuchukwu Nwakoby Md

Nephrology

No abstract provided.


A Case Series Of Hyponatremia And Management In Hospitalized Patients, Jake N. Cho MD, Rebecca Ong MD, Izuchukwu Nwakoby MD 2020 HCA Healthcare

A Case Series Of Hyponatremia And Management In Hospitalized Patients, Jake N. Cho Md, Rebecca Ong Md, Izuchukwu Nwakoby Md

Nephrology

No abstract provided.


Benefits And Harms Of High-Dose Haemodiafiltration Versus High-Flux Haemodialysis: The Comparison Of High-Dose Haemodiafiltration With High-Flux Haemodialysis (Convince) Trial Protocol, Peter J. Blankestijn, Kathrin I. Fischer, Claudia Barth, Krister Cromm, Bernard Canaud, Andrew Davenport, Diederick E. Grobbee, Jorgen Hegbrant, Kit C. Roes, Matthias S. F. Rose, Giovanni Fm. Strippoli, Robin Wm. Vernooij, Mark Woodward, G. Ardine de Wit de, Michiel L. Bots 2020 University Medical Center Utrecht

Benefits And Harms Of High-Dose Haemodiafiltration Versus High-Flux Haemodialysis: The Comparison Of High-Dose Haemodiafiltration With High-Flux Haemodialysis (Convince) Trial Protocol, Peter J. Blankestijn, Kathrin I. Fischer, Claudia Barth, Krister Cromm, Bernard Canaud, Andrew Davenport, Diederick E. Grobbee, Jorgen Hegbrant, Kit C. Roes, Matthias S. F. Rose, Giovanni Fm. Strippoli, Robin Wm. Vernooij, Mark Woodward, G. Ardine De Wit De, Michiel L. Bots

Open Access Articles

INTRODUCTION: End-stage kidney disease (ESKD) is a major public health problem affecting more than 2 million people worldwide. It is one of the most severe chronic non-communicable diseases. Haemodialysis (HD) is the most common therapeutic option but is also associated with a risk of cardiovascular events, hospitalisation and suboptimal quality of life. Over the past decades, haemodiafiltration (HDF) has become available. Although high-dose HDF has shown some promising survival advantage compared to conventional HD, the evidence remains controversial. A Cochrane systematic review found, in low-quality trials, with various convective forms of dialysis, a reduction in cardiovascular, but not all-cause mortality ...


Calcium Alkali Thiazide Syndrome, Mehboob A. Rehan MD, Asma Rashid MD, Reema Singh MD, Gabutti Cristina, Luma Mohsin MD, Tausha Allen MD, Paul Stanford MD, James Thomson MD 2020 HCA Healthcare

Calcium Alkali Thiazide Syndrome, Mehboob A. Rehan Md, Asma Rashid Md, Reema Singh Md, Gabutti Cristina, Luma Mohsin Md, Tausha Allen Md, Paul Stanford Md, James Thomson Md

Internal Medicine

No abstract provided.


Patient And Renal Outcomes Of Posttransplant Lymphoproliferative Disorder Following Solid Organ Transplantations - A Single Center Experience, Kashka Mallari, Goni Katz-Greenberg, Maria Martinez Cantarin 2020 Thomas Jefferson University

Patient And Renal Outcomes Of Posttransplant Lymphoproliferative Disorder Following Solid Organ Transplantations - A Single Center Experience, Kashka Mallari, Goni Katz-Greenberg, Maria Martinez Cantarin

Phase 1

Introduction: Post-transplant Proliferative Disorder (PTLD) is a significant complication after solid organ transplantation (SOT). Major risk factors that contribute to the development of PTLD include Epstein-Barr Virus (EBV) infection and degree of immunosuppression. Despite novel therapies, the 5-year survival rate of PTLD only improved from 40% to 50% over the years. The reported 5-year survival rate of PTLD also remains significantly lower compared to around 90% in other malignancies such as breast and colon cancer. In our center, we hypothesize better transplant outcomes compared to those reported in preceding literatures.

Methods: We retrospectively reviewed the electronic medical records of all ...


Rationale And Design Of A Multicenter Chronic Kidney Disease (Ckd) And At-Risk For Ckd Electronic Health Records-Based Registry: Cure-Ckd., Keith C Norris, O Kenrik Duru, Radica Alicic, Kenn B Daratha, Susanne B Nicholas, Sterling M McPherson, Douglas S Bell, Jenny I Shen, Cami R Jones, Tannaz Moin, Amy D Waterman, Joshua J Neumiller, Roberto B Vargas, Alex A T Bui, Carol M Mangione, Katherine Tuttle 2019 Providence St. Joseph Health, Providence Medical Research Center, Spokane, Washington, USA

Rationale And Design Of A Multicenter Chronic Kidney Disease (Ckd) And At-Risk For Ckd Electronic Health Records-Based Registry: Cure-Ckd., Keith C Norris, O Kenrik Duru, Radica Alicic, Kenn B Daratha, Susanne B Nicholas, Sterling M Mcpherson, Douglas S Bell, Jenny I Shen, Cami R Jones, Tannaz Moin, Amy D Waterman, Joshua J Neumiller, Roberto B Vargas, Alex A T Bui, Carol M Mangione, Katherine Tuttle

Articles, Abstracts, and Reports

BACKGROUND: Chronic kidney disease (CKD) is a global public health problem, exhibiting sharp increases in incidence, prevalence, and attributable morbidity and mortality. There is a critical need to better understand the demographics, clinical characteristics, and key risk factors for CKD; and to develop platforms for testing novel interventions to improve modifiable risk factors, particularly for the CKD patients with a rapid decline in kidney function.

METHODS: We describe a novel collaboration between two large healthcare systems (Providence St. Joseph Health and University of California, Los Angeles Health) supported by leadership from both institutions, which was created to develop harmonized cohorts ...


Severe Hypophosphatemia In A Patient With A Relapsing Lymphoma, Xiaoying Deng, MD, PhD, Edgar Guzman-Suarez, MD, Anju Yadav, MD, Rakesh Gulati, MD 2019 Thomas Jefferson University

Severe Hypophosphatemia In A Patient With A Relapsing Lymphoma, Xiaoying Deng, Md, Phd, Edgar Guzman-Suarez, Md, Anju Yadav, Md, Rakesh Gulati, Md

Department of Medicine Posters

Hypophosphatemia in cancer patients is commonly ascribed to chemotherapy, renal wasting or malnutrition from anorexia and poor PO intake. We report a case caused by rapid cancer cell proliferation. 61-year-old woman with history of marginal zone lymphoma diagnosed in 2017 who presented with fatigue, poor oral intake and undetectable phosphate levels (Phos) for 5 days. Her outpatient medications included Acyclovir 400 mg by mouth daily, Allopurinol 100 mg PO daily and Enoxaparin 60 mg under the skin every 12 hours. Blood work revealed phosphate levels less than1 mg/dl (normal 2.4-4.5mg/dl). Her intact PTH level was normal ...


Spitting Blood And Casts With Mud: A Rare And Unusual Presentation Of C3 Glomerulonephritis, Gerardo Mederos, Harsh Patel, Menalee Hapuarachchi, Som Aftabizadeh, Prashanth Reddy, Ranjit Nair, Dana Ciobanu, Machaiah Madhrira 2019 HCA Healthcare

Spitting Blood And Casts With Mud: A Rare And Unusual Presentation Of C3 Glomerulonephritis, Gerardo Mederos, Harsh Patel, Menalee Hapuarachchi, Som Aftabizadeh, Prashanth Reddy, Ranjit Nair, Dana Ciobanu, Machaiah Madhrira

Internal Medicine

C3 glomerulonephritis (C3GN) is a rare disease that falls under the umbrella of C3 glomerulopathy. It is manifested by abnormal activation of the alternate pathway resulting in complement deposition in the glomeruli. Kidney biopsy with characteristic findings of electron-dense deposits in the mesangial and capillary wall confirms the diagnosis. Until recently, C3GN presenting with primarily lung involvement had not been reported. We present a unique case of initial pulmonary manifestation C3GN.


Transplantation Of Renal Allograft After Removal Of Renal Cell Carcinoma: Case Report And Review Of The Literature, Anthony P. Tran, Paulo N.A. Martins, Zachary G. Papazian, Vijay K. Vanguri, Babak Movahedi, Pang-Yen Fan, Kenneth A. Bodziak, Jennifer K. Yates, Mitchell H. Sokoloff, Adel Bozorgzadeh 2019 University of Massachusetts Medical School

Transplantation Of Renal Allograft After Removal Of Renal Cell Carcinoma: Case Report And Review Of The Literature, Anthony P. Tran, Paulo N.A. Martins, Zachary G. Papazian, Vijay K. Vanguri, Babak Movahedi, Pang-Yen Fan, Kenneth A. Bodziak, Jennifer K. Yates, Mitchell H. Sokoloff, Adel Bozorgzadeh

Open Access Articles

With the rising incidence of end-stage renal disease in the United States, patients needing renal transplants are waiting longer for increasingly scarce grafts. Formerly, the general practice was to avoid organs with tumors for transplant because of the risk of malignancy transmission to the recipient. However, with comprehensive donor selection and a small-sized primary tumor, the positive outcomes of transplant outweigh the risks of transmission after a partial nephrectomy. In our case, a 31-year-old woman, the daughter of the recipient, underwent a laparoscopic nephrectomy with an existing 8-mm tumor later confirmed as renal cell carcinoma. An ex vivo tumor enucleation ...


Improving End Stage Renal Disease Quality Incentive Payment Total Performance Scores, Shelly Guyer, Gina Gregg, Bradley Warady 2019 Children's Mercy Hospital

Improving End Stage Renal Disease Quality Incentive Payment Total Performance Scores, Shelly Guyer, Gina Gregg, Bradley Warady

Posters

The End Stage Rena Disease (ESRD) Quality Incentive Program (QIP) promotes high quality, transparent, cost-efficient care in outpatient dialysis facilities by establishing performance standards that are linked to payment.

The development of a subject matter expert and the sharing of ESRD QIP knowledge resulted in buy-in from dialysis staff and physicians leading to a higher total performance score and the avoidance of payment reduction.


Regional Variation In Chronic Kidney Disease And Associated Factors In Hypertensive Individuals In Rural South Asia: Findings From Control Of Blood Pressure And Risk Attenuation-Bangladesh, Pakistan And Sri Lanka, Liang Feng, Hithanadura Asita de Silva, Imtiaz Jehan, Anuradhani Kasturiratne, Gulshan Himani, Mohammad Abul Hasnat, Tazeen Jafar, COBRA-BPS Study Group 2019 Duke-NUS Medical School, Singapore

Regional Variation In Chronic Kidney Disease And Associated Factors In Hypertensive Individuals In Rural South Asia: Findings From Control Of Blood Pressure And Risk Attenuation-Bangladesh, Pakistan And Sri Lanka, Liang Feng, Hithanadura Asita De Silva, Imtiaz Jehan, Anuradhani Kasturiratne, Gulshan Himani, Mohammad Abul Hasnat, Tazeen Jafar, Cobra-Bps Study Group

Community Health Sciences

Background: We aimed to determine the prevalence of chronic kidney disease (CKD) and its cross-country variation among hypertensive individuals in rural Bangladesh, Pakistan and Sri Lanka. We also explored the factors associated with CKD in these populations.
Method: We studied baseline data from the Control of Blood Pressure and Risk Attenuation-Bangladesh, Pakistan and Sri Lanka (COBRA-BPS) trial, an ongoing cluster randomized controlled trial on 2643 hypertensive adults ≥40 years of age from 30 randomly selected rural clusters, 10 in each of the three countries. CKD was defined as an estimated glomerular filtration rate (eGFR) /min/1.73 m2 or a ...


Effect Of 3-Dimensional Virtual Reality Models For Surgical Planning Of Robotic-Assisted Partial Nephrectomy On Surgical Outcomes: A Randomized Clinical Trial., Joseph D Shirk, David D Thiel, Eric M Wallen, Jennifer M Linehan, Wesley M White, Ketan K Badani, James R Porter 2019 John Wayne Cancer Institute, Providence St John's Health Center, Santa Monica, California

Effect Of 3-Dimensional Virtual Reality Models For Surgical Planning Of Robotic-Assisted Partial Nephrectomy On Surgical Outcomes: A Randomized Clinical Trial., Joseph D Shirk, David D Thiel, Eric M Wallen, Jennifer M Linehan, Wesley M White, Ketan K Badani, James R Porter

Articles, Abstracts, and Reports

Importance: Planning complex operations such as robotic-assisted partial nephrectomy requires surgeons to review 2-dimensional computed tomography or magnetic resonance images to understand 3-dimensional (3-D), patient-specific anatomy.

Objective: To determine surgical outcomes for robotic-assisted partial nephrectomy when surgeons reviewed 3-D virtual reality (VR) models during operative planning.

Design, Setting, and Participants: A single-blind randomized clinical trial was performed. Ninety-two patients undergoing robotic-assisted partial nephrectomy performed by 1 of 11 surgeons at 6 large teaching hospitals were prospectively enrolled and randomized. Enrollment and data collection occurred from October 2017 through December 2018, and data analysis was performed from December 2018 through March ...


A Case Of Essential Thrombocythemia And Iga Nephropathy With Literature Review Of The Concurrence., Shoja Rahimian, Timothy Johnson, Ronald Herb 2019 Reading Hospital-Tower Health

A Case Of Essential Thrombocythemia And Iga Nephropathy With Literature Review Of The Concurrence., Shoja Rahimian, Timothy Johnson, Ronald Herb

Reading Hospital Internal Medicine Residency

Myeloproliferative neoplasms such as essential thrombocythemia (ET) have been associated with glomerular disease on rare instances. A case of ET associated with immunoglobulin A nephropathy (IgAN) is described in a 57-year-old man with a history of hypertension. Progressively worsening renal function was noted in the patient along with unexplained mild thrombocytosis. Pathological review of renal biopsy identified IgAN concurrently with newly diagnosed JAK2-mutated ET. The patient was started on aspirin therapy and closely monitored for his renal function. A literature review of the association of ET and renal disease revealed nine cases of ET associated with IgAN, focal segmental glomerulosclerosis ...


Atypical Hemolytic Uremic Syndrome In The Postpartum Period: A Case Series, Jordan Mattson, Jessica S. Sheng, Kimberly K. Leslie 2019 University of Iowa Hospitals and Clinics

Atypical Hemolytic Uremic Syndrome In The Postpartum Period: A Case Series, Jordan Mattson, Jessica S. Sheng, Kimberly K. Leslie

Proceedings in Obstetrics and Gynecology

Background: Atypical hemolytic uremic syndrome (aHUS) may present in either the antepartum or postpartum period and is often indistinguishable from other pregnancy-associated diseases. Timely recognition and appropriate treatment can greatly reduce maternal morbidity and mortality.

Cases: This case series describes two cases of aHUS in the post-partum period, the difficulty in distinguishing the diagnosis, and the implementation of appropriate treatment with eculizumab, a terminal complement inhibitor.

Conclusion: As a terminal complement inhibitor, eculizumab, has been shown to significantly improve clinical and long term renal outcomes, early diagnosis of aHUS is increasingly important. These two cases of aHUS demonstrate the path ...


Wilms Tumor Survivorship: Does Childhood Cancer Treatment Predict Late-Term Adverse Effects?, Ava Bibergal 2019 DePaul University

Wilms Tumor Survivorship: Does Childhood Cancer Treatment Predict Late-Term Adverse Effects?, Ava Bibergal

Grace Peterson Nursing Research Colloquium

Abstract

Background: Wilms tumor is the leading cancer to affect the kidneys in children most commonly between the age of 3 and 5 years old. Treatment of Wilms tumor typically consists of chemotherapy, radiation, or a combination of the two – which are often successful in eradicating the cancer. However, current treatment options often leave patients with a high risk of late-term adverse effects such as cardiac diseases or secondary cancers later in life. Wilms’ tumor patients currently have a 90% survival rate from their disease, however face a future of indeterminate health problems due to their treatment regimen.

Objectives: The ...


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