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233 full-text articles. Page 1 of 11.

Predictive Value Of Prebronchodilator And Postbronchodilator Spiroometry For Copd Features And Outcomes, Spyridon Fortis, Michael Eberlein, Dimitris Georgopoulos, Alejandro P. Comellas 2017 University of Iowa

Predictive Value Of Prebronchodilator And Postbronchodilator Spiroometry For Copd Features And Outcomes, Spyridon Fortis, Michael Eberlein, Dimitris Georgopoulos, Alejandro P. Comellas

Department of Internal Medicine Publications

Introduction We compared the predictive value of prebronchodilator and postbronchodilator spirometry for chronic obstructive pulmonary disease (COPD) features and outcomes.

Methods We analysed COPDGene data of 10 192 subjects with smoking history. We created regressions models with the following dependent variables: clinical, functional and radiographic features, and the following independent variables: prebronchodilator airflow obstruction (PREO) and postbronchodilator airflow obstruction (POSTO), prebronchodilator and postbronchodilator FEV1% predicted. We compared the model performance using the Akaike information criterion (AIC).

Results The COPD prevalence was higher using PREO. About 8.5% had PREO but no airflow obstruction in postbronchodilator spirometry (POSTN) (PREO-POSTN) and ...


Metabolomics In Copd Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation, Spyridon Fortis, Elizabeth R. Lusczek, Craig R. Weinert, Greg J. Beilman 2017 University of Iowa

Metabolomics In Copd Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation, Spyridon Fortis, Elizabeth R. Lusczek, Craig R. Weinert, Greg J. Beilman

Department of Internal Medicine Publications

We aimed to investigate whether metabolomic analysis can discriminate acute respiratory failure due to COPD exacerbation from respiratory failure due to heart failure and pneumonia. Since COPD exacerbation is often overdiagnosed, we focused on those COPD exacerbations that were severe enough to require noninvasive mechanical ventilation. We enrolled stable COPD subjects and patients with acute respiratory failure requiring noninvasive mechanical ventilation due to COPD, heart failure, and pneumonia. We excluded subjects with history of both COPD and heart failure and patients with obstructive sleep apnea and obstructive lung disease other than COPD. We performed metabolomics analysis using NMR. We constructed ...


Is Engagement Alone Sufficient To Ensure “Active Learning”?, Reed Krause, Amy C. Hayton MD, Jeff Wonoprabowo, Lawrence Loo 2017 Loma Linda University School of Medicine

Is Engagement Alone Sufficient To Ensure “Active Learning”?, Reed Krause, Amy C. Hayton Md, Jeff Wonoprabowo, Lawrence Loo

Loma Linda University Student Journal

“Active Learning” is commonly defined as any instructional method that engages students in the learning process. However, active learning encompasses a broad range of educational methods and its impact on learning outcomes has been variable. In 2015, our IM clerkship redesigned its half-day learning sessions from a largely passive didactic style of lecturing to more active learning approaches. We further revised the curriculum in 2016 to further convert the sessions to primarily case based learning led by a faculty or resident. The goal of our intervention was to increase the Self-Reported Engagement Measure (STOBE) of each didactic session and improve ...


Does Ecg And Arrhythmia Simulation Training In Adjunct To Didactics Improve Medical Students’ Clinical Skills Compared To Didactics Alone?, Reed Krause, Amy C. Hayton MD 2017 Loma Linda University School of Medicine

Does Ecg And Arrhythmia Simulation Training In Adjunct To Didactics Improve Medical Students’ Clinical Skills Compared To Didactics Alone?, Reed Krause, Amy C. Hayton Md

Loma Linda University Student Journal

Medical Schools continue to face the challenge of bridging the gap between classroom education and its application in the clinical environment. Several studies have shown utility of incorporating simulation training into a variety of healthcare related topics. We hypothesize that incorporating ECG and arrhythmia simulation training in adjunction to ECG and arrhythmia didactics; it would improve Year-3 medical students’ preparedness for managing arrhythmias in the clinical setting.


National Trends In Admission And In-Hospital Mortality Of Patients With Heart Failure In The United States (2001–2014), Emmanuel Akintoye, Alexandros Briasoulis, Alexander Egbe, Shannon M. Dunlay, Sudhir Kushwaha, Diane Levine, Luis Afonso, Dariush Mozaffarian, Jarrett Weinberger 2017 Wayne State University

National Trends In Admission And In-Hospital Mortality Of Patients With Heart Failure In The United States (2001–2014), Emmanuel Akintoye, Alexandros Briasoulis, Alexander Egbe, Shannon M. Dunlay, Sudhir Kushwaha, Diane Levine, Luis Afonso, Dariush Mozaffarian, Jarrett Weinberger

Internal Medicine Faculty Publications

Background-—To investigate heart failure (HF) hospitalization trends in the United States and change in trends after publication of management guidelines.

Methods and Results-—Using data from the National Inpatient Sample and the US Census Bureau, annual national estimates in HF admissions and in-hospital mortality were estimated for years 2001 to 2014, during which an estimated 57.4 million HF-associated admissions occurred. Rates (95% confidence intervals) of admissions and in-hospital mortality among primary HF hospitalizations declined by an average annual rate of 3% (2.5%–3.5%) and 3.5% (2.9%–4.0%), respectively. Compared with 2001 to 2005 ...


Sheehan’S Syndrome: It Is Time To Become More Proactive In Identifying This Disease, Yara E. Tovar, Waseem Ahmed, Madhulika Urella, Ayman H. Elkadry, Rodhan A. Khthir 2017 Marshall University Joan C. Edwards School of Medicine

Sheehan’S Syndrome: It Is Time To Become More Proactive In Identifying This Disease, Yara E. Tovar, Waseem Ahmed, Madhulika Urella, Ayman H. Elkadry, Rodhan A. Khthir

Ayman Elkadry

Sheehan’s syndrome typically occurs as a result of ischemic pituitary necrosis due to severe postpartum hemorrhage and can present with varying degrees of pituitary insufficiency. It is more common in underdeveloped countries, and is frequently diagnosed years after delivery due to its nonspecific signs and symptoms. Failure to lactate is a common initial symptom, while many women also report amenorrhea or oligomenorrhea. This article presents a 26-year-old female with a history of hypertension, who presented to the hospital for diarrhea, vomiting, and dizziness. Her blood pressure was 80/40 mmHg, requiring aggressive fluid resuscitation, after which it remained borderline ...


Improved Service Efficiency Improves Racial Disparity In Diabetic Care, Abel Irena, Kushal Patel, David Thompson, Gregory Schleis, Abiy Gesese, Richard Battiola 2017 Department of Internal Medicine, Aurora Sinai Medical Center

Improved Service Efficiency Improves Racial Disparity In Diabetic Care, Abel Irena, Kushal Patel, David Thompson, Gregory Schleis, Abiy Gesese, Richard Battiola

Journal of Patient-Centered Research and Reviews

Background: Racial disparities in diabetes care have been documented. Disparities also have been shown to affect service quality and outcome of diabetic care. Analysis of our internal medicine residency clinic diabetic care management performance across REAL-G (race, ethnicity, age, preferred language and/or gender) showed race-based disparity on two outcome measures: 1) measurement of glycohemoglobin (A1C) at least twice a year; and 2) target blood pressure of < 140/90.

Purpose: Develop interventions to decrease racial disparities in diabetes care among patients managed by an internal medicine residency clinic, as part of the Alliance of Independent Academic Medical Center’s National Initiative V ...


Novel Immunotherapy Treatments: The Adverse Effects Of Nivolumab., Angela Magdaleno DO, Wael Hanna MD 2017 Lehigh Valley Health Network

Novel Immunotherapy Treatments: The Adverse Effects Of Nivolumab., Angela Magdaleno Do, Wael Hanna Md

Department of Medicine

No abstract provided.


Ampa-R Antibody Positive Autoimmune Encephalitis: An Under Recognized Cause Of Acute Mental Status Changes., Joseph Moran DO, George Prousi MD, Stacey Smith MD, FACP 2017 Lehigh Valley Health Network

Ampa-R Antibody Positive Autoimmune Encephalitis: An Under Recognized Cause Of Acute Mental Status Changes., Joseph Moran Do, George Prousi Md, Stacey Smith Md, Facp

Department of Medicine

No abstract provided.


Bilateral Abducens Palsy Secondary To Metastatic Breast Cancer., Paul Secheresiu DO, Yehia Y. Mishriki MD 2017 Lehigh Valley Health Network

Bilateral Abducens Palsy Secondary To Metastatic Breast Cancer., Paul Secheresiu Do, Yehia Y. Mishriki Md

Department of Medicine

No abstract provided.


Ppi Induced Hypomagnesemic Hypoparathyroidism Leading To Posterio Reversible Encephalopathy Syndrome., Anam Malik MD, Shannon Davis DO, Yehia Y. Mishriki MD 2017 Lehigh Valley Health Network

Ppi Induced Hypomagnesemic Hypoparathyroidism Leading To Posterio Reversible Encephalopathy Syndrome., Anam Malik Md, Shannon Davis Do, Yehia Y. Mishriki Md

Department of Medicine

No abstract provided.


A Case Of Refractory Primary Angiitis Of The Central Nervous System., Anam Malik MD, Samer Bolis DO, Susan Kim MD 2017 Lehigh Valley Health Network

A Case Of Refractory Primary Angiitis Of The Central Nervous System., Anam Malik Md, Samer Bolis Do, Susan Kim Md

Department of Medicine

No abstract provided.


A Seemingly Innocuous Headache Heralding Onset Of Rare Autoimmune Disorder., Thomas Quinn DO, Noor Salam MD 2017 Lehigh Valley Health Network

A Seemingly Innocuous Headache Heralding Onset Of Rare Autoimmune Disorder., Thomas Quinn Do, Noor Salam Md

Department of Medicine

No abstract provided.


Sick Sinus Syndrome And Chronic Chagas Cardiomyopathy., Sagar Vadhar DO, Benjamin Sanchez MD 2017 Lehigh Valley Health Network

Sick Sinus Syndrome And Chronic Chagas Cardiomyopathy., Sagar Vadhar Do, Benjamin Sanchez Md

Department of Medicine

No abstract provided.


Encephalopathy Secondary To Aggressive Cd5+ Dlbcl Versus Herpes Zoster Encephalitis., Kathryn Kass MD 2017 Lehigh Valley Health Network

Encephalopathy Secondary To Aggressive Cd5+ Dlbcl Versus Herpes Zoster Encephalitis., Kathryn Kass Md

Department of Medicine

No abstract provided.


Essentiality Of Regulator Of G Protein Signaling 6 And Oxidized Ca2+/Calmodulin-Dependent Protein Kinase Ii In Notch Signaling And Cardiovascular Development, Bandana Chakravarti, Jianqi Yang, Katelin E Ahlers-Dannen, Zili Luo, Heather A Flaherty, David K Meyerholz, Mark E Anderson, Rory A Fisher 2017 University of Iowa

Essentiality Of Regulator Of G Protein Signaling 6 And Oxidized Ca2+/Calmodulin-Dependent Protein Kinase Ii In Notch Signaling And Cardiovascular Development, Bandana Chakravarti, Jianqi Yang, Katelin E Ahlers-Dannen, Zili Luo, Heather A Flaherty, David K Meyerholz, Mark E Anderson, Rory A Fisher

Department of Internal Medicine Publications

BACKGROUND: Congenital heart defects are the most common birth defects worldwide. Although defective Notch signaling is the major cause of mouse embryonic death from cardiovascular defects, how Notch signaling is regulated during embryonic vasculogenesis and heart development is poorly understood.

METHODS AND RESULTS: Regulator of G protein signaling 6 (RGS6)-/-/Ca2+/calmodulin-dependent protein kinase II (CaMKII)VV double mutant mice were developed by crossing RGS6-/- mice with mice expressing an oxidation-resistant CaMKIIδ (CaMKIIVV), and the resulting embryonic defects/lethality were investigated using E7.5 to E15.5 embryos. While loss of either RGS6 or oxidized CaMKIIδ does not alter embryogenesis ...


Sheehan’S Syndrome: It Is Time To Become More Proactive In Identifying This Disease, Yara E. Tovar, Waseem Ahmed, Madhulika Urella, Ayman H. Elkadry, Rodhan A. Khthir 2017 Marshall University Joan C. Edwards School of Medicine

Sheehan’S Syndrome: It Is Time To Become More Proactive In Identifying This Disease, Yara E. Tovar, Waseem Ahmed, Madhulika Urella, Ayman H. Elkadry, Rodhan A. Khthir

Marshall Journal of Medicine

Sheehan’s syndrome typically occurs as a result of ischemic pituitary necrosis due to severe postpartum hemorrhage and can present with varying degrees of pituitary insufficiency. It is more common in underdeveloped countries, and is frequently diagnosed years after delivery due to its nonspecific signs and symptoms. Failure to lactate is a common initial symptom, while many women also report amenorrhea or oligomenorrhea. This article presents a 26-year-old female with a history of hypertension, who presented to the hospital for diarrhea, vomiting, and dizziness. Her blood pressure was 80/40 mmHg, requiring aggressive fluid resuscitation, after which it remained borderline ...


The Opioid Crisis., Jennifer Stephens DO 2017 Lehigh Valley Health Network

The Opioid Crisis., Jennifer Stephens Do

Department of Medicine

No abstract provided.


Duodenal Varices: A Rare Cause Of Gastrointestinal Bleeding., Anam Malik MD, Abdul Aleeem MD, Eric Nellis MD, Hiral N. Shah MD 2017 Lehigh Valley Health Network

Duodenal Varices: A Rare Cause Of Gastrointestinal Bleeding., Anam Malik Md, Abdul Aleeem Md, Eric Nellis Md, Hiral N. Shah Md

Department of Medicine

No abstract provided.


Initial Experience Of A Community Gastroenterology Practice With Ultra-Slim Colonoscopy: A Case Series., Rajesh Essrani MD, Patrick Hickey DO, Hiral N. Shah MD, Paola Blanco MD 2017 Lehigh Valley Health Network

Initial Experience Of A Community Gastroenterology Practice With Ultra-Slim Colonoscopy: A Case Series., Rajesh Essrani Md, Patrick Hickey Do, Hiral N. Shah Md, Paola Blanco Md

Department of Medicine

No abstract provided.


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