Rheumatology Commons^™

Long-Term Safety Of Pegloticase In Chronic Gout Refractory To Conventional Treatment, Michael A. Becker, Herbert S. B. Baraf, Robert A. Yood, Aileen Dillon, Janitzia Vazquez-Mellado, Faith D. Ottery, Dinesh Khanna, John S. Sundy

Meyers Primary Care Institute Publications and Presentations

OBJECTIVE: To evaluate the long-term safety (up to 3 years) of treatment with pegloticase in patients with refractory chronic gout.

METHODS: This open-label extension (OLE) study was conducted at 46 sites in the USA, Canada and Mexico. Patients completing either of two replicate randomised placebo-controlled 6-month trials received pegloticase 8 mg every 2 weeks (biweekly) or every 4 weeks (monthly). Safety was evaluated as the primary outcome, with special interest in gout flares and infusion-related reactions (IRs). Secondary outcomes included urate-lowering and clinical efficacy.

RESULTS: Patients (n=149) received a mean+/-SD of 28+/-18 pegloticase infusions and were followed ...

Patients' Knowledge And Beliefs Concerning Gout And Its Treatment: A Population Based Study, Leslie R. Harrold, Kathleen M. Mazor, Daniel J. Peterson, Nausheen Naz, Cassandra L. Firneno, Robert A. Yood

Meyers Primary Care Institute Publications and Presentations

BACKGROUND: For patients to effectively manage gout, they need to be aware of the impact of diet, alcohol use, and medications on their condition. We sought to examine patients' knowledge and beliefs concerning gout and its treatment in order to identify barriers to optimal patient self-management.

METHODS: We identified patients (>/=18 years of age) cared for in the setting of a multispecialty group practice with documentation of at least one health care encounter associated with a gout diagnosis during the period 2008-2009 (n = 1346). Patients were sent a questionnaire assessing knowledge with regard to gout, beliefs about prescription medications used ...

The Effect Of Physical Activity On Medial Tibial Cartilage Health In Clinical Knee Osteoarthritis, Connie Ma

Open Access Dissertations and Theses

Knee osteoarthritis (OA) is a common chronic disease that often occurs in older adults, affecting their quality of life. The purposes of this study were to examine 1) the relationship between physical activity and medial tibial cartilage volume and thickness in participants with clinical knee OA; and 2) the test-retest reliability of daily step counts produced by participants with knee OA.

The study included 34 participants (age 60.6 ± 6.5 years; body mass index 28.5 ± 5.4 kg/m²). Dependent variables were medial tibial cartilage volume and thickness, measured from magnetic resonance images. Independent variables were average ...

Malignancy Validation In A United States Registry Of Rheumatoid Arthritis Patients, Mark C. Fisher, Victoria Furer, Marc C. Hochberg, Jeffrey D. Greenberg, Joel M. Kremer, Jeffrey R. Curtis, George W. Reed, Leslie R. Harrold, Daniel H. Solomon

Open Access Articles

BACKGROUND: Physician reporting is commonly used to ascertain adverse events or outcomes measured in epidemiologic studies. However, little is known on the accuracy of physician reported malignancies compared to pertinent medical record review in large cohort studies.

METHODS: The Consortium of Rheumatology Researchers of North America (CORRONA) registry gathers physician-completed questionnaires for rheumatoid arthritis (RA) patients, including request for information on incident malignancies, approximately every three months. For incident malignancies reported from October 1st, 2001, through December 31st, 2007, we retrospectively requested completion of a Targeted Adverse Event (TAE) form for additional information as well as primary source documents to ...

Magnetic Resonance And Radiography In Rheumatoid Arthritis: Intermodality Comparisons Of Erosion Detection, Ruben V. Tavares

Open Access Dissertations and Theses

BACKGROUND. Classically, radiography (x-ray) has been used to visualize the destructive effects of uncontrolled rheumatoid arthritis (RA) on articular bones. Both x-ray and magnetic resonance imaging (MRI) may be used to visualize erosive disease. The multi-slice and multi-planar characteristics of MRI provide greater detail per anatomy imaged than x-ray.

OBJECTIVE. The objective of this dissertation was to compare the relative merits of x-ray and MRI erosion detection.

METHODS. In Chapters 1 through 3, RA, its clinical management, and the role of diagnostic imaging were introduced. In Chapter 4, the overall objective was first investigated by evaluating the current state of ...

Gout Knowledge, Beliefs And Treatment Practices In A National Sample Of Us Primary Care Providers, Leslie R. Harrold, Kathleen M. Mazor, Amarie Negron, Jessica Ogarek, Cassandra L. Firneno, Robert A. Yood

Clinical and Translational Science Research Retreat

Objectives: We sought to examine primary care providers’ gout knowledge and reported treatment patterns in comparison to current treatment recommendations.

Methods: We conducted a national survey of a random sample of primary care physicians (internists and family practitioners) to assess their treatment of acute, intercritical, and tophaceous gout in comparison to published European and American gout treatment recommendations and guidelines.

Results: There were 838 respondents (response rate of 41%) most of whom worked in private practice (63%) with >16 years experience (52%). For acute podagra, 16% reported care consistent with the recommendations including avoidance of anti-inflammatory drugs in the setting ...

Force-Tjr: Innovative Design For A National Tjr Comparative Effectiveness Research Database, Patricia D. Franklin, Jeroan J. Allison, Wenjun Li, Leslie R. Harrold, Bruce A. Barton, Benjamin Snyder, Milagros C. Rosal, Norman Weissman, John E. Ware Jr., David C. Ayers

Clinical and Translational Science Research Retreat

BACKGROUND: Joint replacement (TJR) registries have traditionnally focused on collecting implant data and analyzing time-to-revision. Sub-optimal outcomes short of revision are important to surgeons and patients. In 2010, the US federal Agency for Healthcare Research and Quality funded Function and Outcomes Research for Comparative Effectiveness in TJR (FORCE-TJR), a research consortium and database to collect comprehensive TJR outcomes, including patient-reported pain and function and post-operative sequelae. This $12 million research award will provide new information about post-TJR adverse events, patient-reported functional gain, and implant longevity. We developed novel methods to assure critical data collection and sustainability.

METHODS: FORCE-TJR developed methods ...