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284 full-text articles. Page 10 of 14.

Formula Using Routine Biochemical Markers Proved Superior To Forn's And Apri In Predicting Early Vs. Late-Stage Liver Disease In The Hiv/Hcv Co-Infected Host, Margaret Hoffman-Terry MD, FACP, Joseph L. Yozviak DO, FACP, J Mannino, Sharon R. Kimmel PhD, MHA 2013 Lehigh Valley Health Network

Formula Using Routine Biochemical Markers Proved Superior To Forn's And Apri In Predicting Early Vs. Late-Stage Liver Disease In The Hiv/Hcv Co-Infected Host, Margaret Hoffman-Terry Md, Facp, Joseph L. Yozviak Do, Facp, J Mannino, Sharon R. Kimmel Phd, Mha

Joseph L Yozviak DO, FACP

No abstract provided.


A Novel Approach For A New Era: Successful Integration Of Multidisciplinary, Hepatitis C Care Within An Established Hiv Primary Care Practice, Joseph L. Yozviak DO, FACP, Orlando J. Penaloza MD, FACP, Timothy J. Friel MD 2013 Lehigh Valley Health Network

A Novel Approach For A New Era: Successful Integration Of Multidisciplinary, Hepatitis C Care Within An Established Hiv Primary Care Practice, Joseph L. Yozviak Do, Facp, Orlando J. Penaloza Md, Facp, Timothy J. Friel Md

Joseph L Yozviak DO, FACP

No abstract provided.


Expanding Access To Care Through A Resident-Initiated Hepatitis C Clinic - An Innovative Method For Incorporating Acgme Core Competencies Into The Management Of Medically Underserved Patients, Joseph L. Yozviak DO, FACP, Suzanne J. Templer DO, Erini Vasiliadis DO, Vishal Patel MD, Nicole M. Agostino DO, K Nadeem Ahmed MD, Edward Norris MD, FAPM, Charles M. Brooks MD, Eric J. Gertner MD, MPH 2013 Lehigh Valley Health Network

Expanding Access To Care Through A Resident-Initiated Hepatitis C Clinic - An Innovative Method For Incorporating Acgme Core Competencies Into The Management Of Medically Underserved Patients, Joseph L. Yozviak Do, Facp, Suzanne J. Templer Do, Erini Vasiliadis Do, Vishal Patel Md, Nicole M. Agostino Do, K Nadeem Ahmed Md, Edward Norris Md, Fapm, Charles M. Brooks Md, Eric J. Gertner Md, Mph

Joseph L Yozviak DO, FACP

No abstract provided.


A Survey Of Primary Care Residents Regarding Knowledge Of Hepatitis C, Joseph L. Yozviak DO, FACP, Erini Vasiliadis DO, Sharon R. Kimmel PhD, MHA, Suzanne J. Templer DO, Margaret Hoffman-Terry MD, FACP 2013 Lehigh Valley Health Network

A Survey Of Primary Care Residents Regarding Knowledge Of Hepatitis C, Joseph L. Yozviak Do, Facp, Erini Vasiliadis Do, Sharon R. Kimmel Phd, Mha, Suzanne J. Templer Do, Margaret Hoffman-Terry Md, Facp

Joseph L Yozviak DO, FACP

No abstract provided.


Ifn-Gamma Production By Human Natural Killer Cells In Response To Hcv-Infected Hepatoma Cells Is Dependent On Accessory Cells, Shuye Zhang, Banishree Saha, Karen Kodys, Gyongyi Szabo 2013 University of Massachusetts Medical School

Ifn-Gamma Production By Human Natural Killer Cells In Response To Hcv-Infected Hepatoma Cells Is Dependent On Accessory Cells, Shuye Zhang, Banishree Saha, Karen Kodys, Gyongyi Szabo

Gyongyi Szabo

BACKGROUND and AIMS: Interferon-gamma (IFN-gamma), a cytokine produced by activated natural killer cell (NK) and T lymphocytes, is an important regulator of innate and adaptive immunity during hepatitis C virus (HCV) infection. However, the cellular sources and mechanisms of IFN-gamma induction in HCV-infection are not fully understood. METHODS: We cultured normal human peripheral blood mononuclear cells (PBMCs) with different populations of immune cells and JFH-1 HCV-infected Huh7.5 (JFH-1/Huh7.5) cells. RESULTS: We found that PBMCs produced large amounts of IFN-gamma after co-culture with JFH-1/Huh7.5 cells. Using intracellular cytokine staining we confirmed that NK cells and NKT ...


Micrornas In Liver Disease, Gyongyi Szabo, Shashi Bala 2013 University of Massachusetts Medical School

Micrornas In Liver Disease, Gyongyi Szabo, Shashi Bala

Gyongyi Szabo

Small, noncoding microRNAs (miRNAs) regulate diverse biological functions in the liver and increasing evidence suggests that they have a role in liver pathology. This Review summarizes advances in the field of miRNAs in liver diseases, inflammation and cirrhosis. MicroRNA-122, the most abundant miRNA in hepatocytes, has well-defined roles in HCV replication, and data indicate that it also serves as a viable therapeutic target. The role of miR-122 is also emerging in other liver diseases. Ample evidence exists for the important regulatory potential of other miRNAs in conditions associated with liver inflammation related to alcohol use, the metabolic syndrome or autoimmune ...


Evaluation Of Clinical Outcomes Of Prophylactic Versus Preemptive Cytomegalovirus Strategy In Liver Transplant Recipients, Ifeanyi Onor, Sarah Todd, Erika Meredith, Sebastian Perez, Aneesh Mehta, G Lyon, Stuart Knechtle, Steven Hanish 2013 Xavier University of Louisiana

Evaluation Of Clinical Outcomes Of Prophylactic Versus Preemptive Cytomegalovirus Strategy In Liver Transplant Recipients, Ifeanyi Onor, Sarah Todd, Erika Meredith, Sebastian Perez, Aneesh Mehta, G Lyon, Stuart Knechtle, Steven Hanish

Faculty and Staff Publications

Cytomegalovirus (CMV) is a major cause of morbidity and mortality following solid organ transplantation (SOT). Two strategies, prophylactic, and preemptive have emerged for the prevention of CMV infection and disease after SOT. This retrospective chart review of two liver transplant cohorts: prophylactic and preemptive, compares the clinical impact of transitioning from prophylactic to preemptive strategy. The primary outcome is the incidence of CMV viremia at 3-and 6-months post-transplant. Secondary outcomes include: incidence of CMV tissue-invasive disease, acute cellular rejection, leukopenia and neutropenia, opportunistic infection rates, hospital readmission rates, and mortality at 3-and 6-months post-transplant. A total of 109 patients were ...


Human Monoclonal Antibody Mbl-Hcv1 Delays Hcv Viral Rebound Following Liver Transplantation: A Randomized Controlled Study, R. Chung, F. Gordon, M. Curry, T. Schiano, S. Emre, K. Corey, J. Markmann, M. Hertl, J. Pomposelli, E. Pomfret, S. Florman, M. Schilsky, Teresa Broering, Robert Finberg, Gyongyi Szabo, Phillip Zamore, U. Khettry, Gregory Babcock, Donna Ambrosino, Brett Leav, Mark Leney, H. Smith, Deborah Molrine 2013 Massachusetts General Hospital

Human Monoclonal Antibody Mbl-Hcv1 Delays Hcv Viral Rebound Following Liver Transplantation: A Randomized Controlled Study, R. Chung, F. Gordon, M. Curry, T. Schiano, S. Emre, K. Corey, J. Markmann, M. Hertl, J. Pomposelli, E. Pomfret, S. Florman, M. Schilsky, Teresa Broering, Robert Finberg, Gyongyi Szabo, Phillip Zamore, U. Khettry, Gregory Babcock, Donna Ambrosino, Brett Leav, Mark Leney, H. Smith, Deborah Molrine

Gyongyi Szabo

Rapid allograft infection complicates liver transplantation (LT) in patients with hepatitis C virus (HCV). Pegylated interferon-alpha and ribavirin therapy after LT has significant toxicity and limited efficacy. The effect of a human monoclonal antibody targeting the HCV E2 glycoprotein (MBL-HCV1) on viral clearance was examined in a randomized, double-blind, placebo-controlled pilot study in patients infected with HCV genotype 1a undergoing LT. Subjects received 11 infusions of 50 mg/kg MBL-HCV1 (n=6) or placebo (n=5) intravenously with three infusions on day of transplant, a single infusion on days 1 through 7 and one infusion on day 14 after LT ...


Targeting Heat Shock Protein 90 Alters Epigenetic Genes In Alcoholic Liver Disease, Aditya Ambade, Pranoti Mandrekar 2013 University of Massachusetts Medical School

Targeting Heat Shock Protein 90 Alters Epigenetic Genes In Alcoholic Liver Disease, Aditya Ambade, Pranoti Mandrekar

UMass Center for Clinical and Translational Science Research Retreat

Chronic alcohol induces acetylation and methylation of chromatin-associated histones that influence transcriptional activity of genes. Molecular chaperone heat shock protein 90 (hsp90) is being recognized as mediator of chromatin remodeling and is upregulated in alcoholic liver disease. We hypothesize that hsp90 plays a pivotal role in altered expression of chromatin modifying enzymes during alcoholic liver injury. To test our hypotheses, C57Bl/6 mice were fed Lieber-deCarli diet with 5% v/v ethanol for 10 days followed by a binge containing 20%v/v alcohol. A single injection of hsp90 inhibitor, 17-DMAG [17-Dimethylamino-ethylamino-17-demethoxygeldanamycin] was administered (30-50 mg/kg BW) i.p ...


Hepatocellular Carcinoma In Native South Asian Pakistani Population; Trends, Clinico-Pathological Characteristics & Differences In Viral Marker Negative & Viral-Hepatocellular Carcinoma, Amna Subhan Butt1, Saeed Hamid, Ashfaq Ahmad Wadalawala, Mariam Ghufran, Ammar Asrar Javed, Omer Farooq, Bilal Ahmed, Tanveer Ul Haq, Wasim Jafri 2013 Aga Khan University

Hepatocellular Carcinoma In Native South Asian Pakistani Population; Trends, Clinico-Pathological Characteristics & Differences In Viral Marker Negative & Viral-Hepatocellular Carcinoma, Amna Subhan Butt1, Saeed Hamid, Ashfaq Ahmad Wadalawala, Mariam Ghufran, Ammar Asrar Javed, Omer Farooq, Bilal Ahmed, Tanveer Ul Haq, Wasim Jafri

Section of Gastroenterology

Background

HCC is the fifth most common cancer globally. Our study was conducted to (1)investigate the trends and clinico-pathological characteristics of Hepatocellular carcinoma among native South Asian patients in Pakistan, (2)to estimate the prevalence as well as the trends of viral marker negative HCC and (3) to compare the clinico-pathological, radiological characteristics, applicability of treatment at diagnosis and prognostic factors among patients with both viral marker negative and viral marker positive-HCC being consulted at Aga Khan University Hospital(AKUH), Karachi, Pakistan.

Method

Patients ≥18 years, already diagnosed to have HCC and visiting AKUH during 1999–2009 were identified ...


A Multicenter, Prospective Study Of A New Fully Covered Expandable Metal Biliary Stent For The Palliative Treatment Of Malignant Bile Duct Obstruction., Bret T Petersen, Michel Kahaleh, Richard A Kozarek, David E. Loren, Kapil Gupta, Thomas E. Kowalski, Martin Freeman, Yang K Chen, Malcolm S Branch, Steven Edmundowicz, Michael Gluck, Kenneth Binmoeller, Todd H Baron, Raj J Shah, Timothy Kinney, William Ross, Paul Jowell, David Carr-Locke 2013 Mayo Clinic, 200 1st Street SW, Rochester, MN

A Multicenter, Prospective Study Of A New Fully Covered Expandable Metal Biliary Stent For The Palliative Treatment Of Malignant Bile Duct Obstruction., Bret T Petersen, Michel Kahaleh, Richard A Kozarek, David E. Loren, Kapil Gupta, Thomas E. Kowalski, Martin Freeman, Yang K Chen, Malcolm S Branch, Steven Edmundowicz, Michael Gluck, Kenneth Binmoeller, Todd H Baron, Raj J Shah, Timothy Kinney, William Ross, Paul Jowell, David Carr-Locke

Division of Gastroenterology and Hepatology Faculty Papers

Background and Study Aims. Endoscopic placement of self-expanding metal stents (SEMSs) is indicated for palliation of inoperable malignant biliary obstruction. A fully covered biliary SEMS (WallFlex Biliary RX Boston Scientific, Natick, USA) was assessed for palliation of extrahepatic malignant biliary obstruction. Patients and Methods. 58 patients were included in this prospective, multicenter series conducted under an FDA-approved IDE. Main outcome measurements included (1) absence of stent occlusion within six months or until death, whichever occurred first and (2) technical success, need for reintervention, bilirubin levels, stent patency, time to stent occlusion, and adverse events. Results. Technical success was achieved in ...


Association Between Γ-Glutamyl Transferase And Metabolic Syndrome: A Cross-Sectional Study Of An Adult Population In Beijing, Lixin Tao, Xia Li, Huiping Zhu, Yue Gao, Yanxia Luo, Wei Wang, Zhaoping Wang, Dongning Chen, Lijuan Wu, Xiuhua Guo 2013 Edith Cowan University

Association Between Γ-Glutamyl Transferase And Metabolic Syndrome: A Cross-Sectional Study Of An Adult Population In Beijing, Lixin Tao, Xia Li, Huiping Zhu, Yue Gao, Yanxia Luo, Wei Wang, Zhaoping Wang, Dongning Chen, Lijuan Wu, Xiuhua Guo

ECU Publications 2013

The relationship between liver enzymes and clustered components of metabolic syndrome (MetS) is explored and the predictive power of γ-glutamyl transferase (GGT) for the diagnosis of MetS in an adult population in Beijing is investigated. A total of 10,553 adults aged 20-65 years who underwent health examinations at Beijing Tongren Hospital in 2012 were enrolled in the study. Multivariate logistic regression analysis is conducted to determine the associations between the levels of various liver enzymes and clustered components of MetS. A receiver operating characteristic analysis is used to determine the optimal cut-off value of GGT for the diagnosis of ...


Help! My Dog Was Diagnosed With A Liver Problem! Understanding Common Liver Disorders In Yorkshire Terriers & Other Toy Breeds, Karen M. Tobias 2012 University of Tennessee, Knoxville

Help! My Dog Was Diagnosed With A Liver Problem! Understanding Common Liver Disorders In Yorkshire Terriers & Other Toy Breeds, Karen M. Tobias

Karen M. Tobias DVM, DACVS, College of Veterinary Medicine

No abstract provided.


Limited Sampling Estimates Of Epigallocatechin Gallate Exposures In Cirrhotic And Noncirrhotic Patients With Hepatitis C After Single Oral Doses Of Green Tea Extract., Dina Halegoua-De Marzio, Walter K. Kraft, Constantine Daskalakis, Xie Ying, Roy L Hawke, Victor J. Navarro 2012 Thomas Jefferson University

Limited Sampling Estimates Of Epigallocatechin Gallate Exposures In Cirrhotic And Noncirrhotic Patients With Hepatitis C After Single Oral Doses Of Green Tea Extract., Dina Halegoua-De Marzio, Walter K. Kraft, Constantine Daskalakis, Xie Ying, Roy L Hawke, Victor J. Navarro

Division of Gastroenterology and Hepatology Faculty Papers

BACKGROUND: Epigallocatechin-3-gallate (EGCG) has antiangiogenic, antioxidant, and antifibrotic properties that may have therapeutic potential for the treatment of cirrhosis induced by hepatitis C virus (HCV). However, cirrhosis might affect EGCG disposition and augment its reported dose-dependent hepatotoxic potential.

OBJECTIVE: The safety, tolerability, and disposition of a single oral dose of EGCG in cirrhotic patients with HCV were examined in an exploratory fashion.

METHODS: Eleven patients with hepatitis C and detectable viremia were enrolled. Four had Child-Pugh (CP) class A cirrhosis, 4 had Child-Pugh class B cirrhosis, and 3 were noncirrhotic. After a single oral dose of green tea extract 400 ...


The Association Between Acrochorda (Skin Tags), Metabolic Syndrome, And Adenomatous Polyps, Brendan O'Hare, MD, Anastasia Shnitser, MD, Jason Korenblit, MD, MBA, Ali Siddiqui, MD 2012 Thomas Jefferson University

The Association Between Acrochorda (Skin Tags), Metabolic Syndrome, And Adenomatous Polyps, Brendan O'Hare, Md, Anastasia Shnitser, Md, Jason Korenblit, Md, Mba, Ali Siddiqui, Md

Division of Gastroenterology and Hepatology Faculty Papers

BACKGROUND

Acrochorda (skin tags) are benign skin tumors that form primarily at skin creases, generally on the neck, armpit, and groin areas. There have been a small number of published studies in 1980s in patients who were found to have increased number of skin tags and colonic polyps, with a direct correlation described between the two. In addition, metabolic syndrome has been linked to adenomatous polyps, but a link between skin tags and metabolic syndrome has not been established.


Development Of A Competency-Based Transplant Hepatology Fellowship, Steven K. Herrine, Andrew P. Keaveny, Ayman Abdel-Latif Koteish, Richard K. Sterling, John R. Lake 2012 Thomas Jefferson University

Development Of A Competency-Based Transplant Hepatology Fellowship, Steven K. Herrine, Andrew P. Keaveny, Ayman Abdel-Latif Koteish, Richard K. Sterling, John R. Lake

Division of Gastroenterology and Hepatology Faculty Papers

Presented at 63rd annual meeting AASLD, The Liver Meeting, Boston MA, November 9-13, 2012.

Purpose: The Accreditation Council for Graduate Medical Education (ACGME) next accreditation system (NAS) provides incentive for medical educators to understand and implement competency-based medical education (CBME) training and assessment in their programs. Noting decreasing enrollees for the American Board of Internal Medicine (ABIM) Transplant Hepatology (TH) exam, workforce concerns in TH, and questionnaire data from Gastroenterology (GI) fellows and Program Directors (PDs), we developed an ABIM-approved one-year competency-based TH pilot program.


Inflammasomes In Liver Diseases, Gyongyi Szabo, Timea Csak 2012 University of Massachusetts Medical School

Inflammasomes In Liver Diseases, Gyongyi Szabo, Timea Csak

Gyongyi Szabo

Inflammation is a common element in the pathogenesis of most chronic liver diseases that lead to fibrosis and cirrhosis. Inflammation is characterized by activation of innate immune cells and production of pro-inflammatory cytokines IL-1alpha, IL-1beta, and TNFalpha. Inflammasomes are intracellular multiprotein complexes expressed in both parenchymal and non-parenchymal cells of the liver that in response to cellular danger signals activate caspase-1, and release IL-1beta and IL-18. The importance of inflammasome activation in various forms of liver diseases in relation to liver damage, steatosis, inflammation and fibrosis is discussed in this review. Elsevier B.V. All rights reserved.


Hypoxia And Hypoxia Inducible Factors: Diverse Roles In Liver Diseases, Bharath Nath, Gyongyi Szabo 2012 University of Massachusetts Medical School

Hypoxia And Hypoxia Inducible Factors: Diverse Roles In Liver Diseases, Bharath Nath, Gyongyi Szabo

Gyongyi Szabo

Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The hypoxia inducible factors (HIFs) are a family of evolutionarily conserved transcriptional regulators that affect a homeostatic response to low oxygen tension and have been identified as key mediators of angiogenesis, inflammation, and metabolism. In this review we summarize the evidence for a role of HIFs across a range of hepatic pathophysiology. We describe regulation of the HIFs and review investigations that demonstrate a role for HIFs in the development of liver fibrosis, activation of innate immune pathways, hepatocellular carcinoma, as well as ...


Microrna Signature In Alcoholic Liver Disease, Shashi Bala, Gyongyi Szabo 2012 University of Massachusetts Medical School

Microrna Signature In Alcoholic Liver Disease, Shashi Bala, Gyongyi Szabo

Gyongyi Szabo

Alcoholic liver disease (ALD) is a major global health problem. Chronic alcohol use results in inflammation and fatty liver, and in some cases, it leads to fibrosis and cirrhosis or hepatocellular carcinoma. Increased proinflammatory cytokines, particularly TNF alpha, play a central role in the pathogenesis of ALD. TNF alpha is tightly regulated at transcriptional and posttranscriptional levels. Recently, microRNAs (miRNAs) have been shown to modulate gene functions. The role of miRNAs in ALD is getting attention, and recent studies suggest that alcohol modulates miRNAs. Recently, we showed that alcohol induces miR-155 expression both in vitro (RAW 264.7 macrophage) and ...


The Presence Of P47phox In Liver Parenchymal Cells Is A Key Mediator In The Pathogenesis Of Alcoholic Liver Steatosis, Ivan Levin, Jan Petrasek, Gyongyi Szabo 2012 University of Massachusetts Medical School

The Presence Of P47phox In Liver Parenchymal Cells Is A Key Mediator In The Pathogenesis Of Alcoholic Liver Steatosis, Ivan Levin, Jan Petrasek, Gyongyi Szabo

Gyongyi Szabo

BACKGROUND: Reactive oxygen species contribute to steatosis and inflammation in alcoholic liver disease (ALD). Here, we evaluated the selective contribution of p47phox, a critical subunit of nicotinamide adenine dinucleotide phosphate oxidase (NADPH) oxidase complex, in liver parenchymal cells and in bone marrow (BM)-derived cells. METHODS: Female C57Bl/6 wild type [WT], total body p47phox-deficient knockout [KO] or p47phox chimera mice generated by BM transplantation of p47phox-KO-BM into irradiated WT mice (WT/p47phox-KO-BM mice) received 5% Lieber-DeCarli alcohol or control (pair feeding) diet for 4 weeks. RESULTS: Alcohol-induced liver steatosis as measured by Oil Red O staining and serum triglyceride ...


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