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Hepatology Commons

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328 full-text articles. Page 7 of 16.

It Is Reasonable To Treat Patients With Type 1 Hepatorenal Syndrome With Midodrine And Octreotide, William Kane 2016 Wayne State University

It Is Reasonable To Treat Patients With Type 1 Hepatorenal Syndrome With Midodrine And Octreotide, William Kane

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Esrailian E, Pantangco ER, Kyulo NL, Hu KQ, Runyon BA. Octreotide/midodrine therapy significantly improves renal function and 30-day survival in patients with type 1 hepatorenal syndrome. Dig Dis Sci. 2007;52(3):742-748. doi: 10.1007/s10620-006-9312-0


Salvage Therapy For Non-Acetaminophen-Induced Acute Liver Failure Includes N-Acetylcysteine, David Robinson 2016 Wayne State University School of Medicine

Salvage Therapy For Non-Acetaminophen-Induced Acute Liver Failure Includes N-Acetylcysteine, David Robinson

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Lee WM, Hynan LS, Rossaro L, et al. Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure. Gastroenterology. 2009;137(3):856-864. doi: 10.1053/j.gastro.2009.06.006


Could There Be Light At The End Of The Tunnel? Mesocaval Shunting For Refractory Esophageal Varices In Patients With Contraindications To Transjugular Intrahepatic Portosystemic Shunt., Jessica Davis, Albert K Chun, Marie L Borum 2016 George Washington University

Could There Be Light At The End Of The Tunnel? Mesocaval Shunting For Refractory Esophageal Varices In Patients With Contraindications To Transjugular Intrahepatic Portosystemic Shunt., Jessica Davis, Albert K Chun, Marie L Borum

Surgery Faculty Publications

Cirrhotic patients with recurrent variceal bleeds who have failed prior medical and endoscopic therapies and are not transjugular intrahepatic portosystemic shunt candidates face a grim prognosis with limited options. We propose that mesocaval shunting be offered to this group of patients as it has the potential to decrease portal pressures and thus decrease the risk of recurrent variceal bleeding. Mesocaval shunts are stent grafts placed by interventional radiologists between the mesenteric system, most often the superior mesenteric vein, and the inferior vena cava. This allows flow to bypass the congested hepatic system, reducing portal pressures. This technique avoids the general ...


Potential Approaches To Improve The Outcomes Of Donation After Cardiac Death Liver Grafts, Paria Mahboub, Adel Bozorgzadeh, Paulo N.A. Martins 2016 University of Massachusetts Medical School

Potential Approaches To Improve The Outcomes Of Donation After Cardiac Death Liver Grafts, Paria Mahboub, Adel Bozorgzadeh, Paulo N.A. Martins

Surgery Publications

There is a growing discrepancy between the supply and demand of livers for transplantation resulting in high mortality rates on the waiting list. One of the options to decrease the mortality on the waiting list is to optimize organs with inferior quality that otherwise would be discarded. Livers from donation after cardiac death (DCD) donors are frequently discarded because they are exposed to additional warm ischemia time, and this might lead to primary-non-function, delayed graft function, or severe biliary complications. In order to maximize the usage of DCD livers several new preservation approaches have been proposed. Here, we will review ...


Redefining Budd-Chiari Syndrome: A Systematic Review, Naomi Shin, Young H. Kim, Hao Xu, Hai-Bin Shi, Qing-Qiao Zhang, Jean Paul Colon Pons, Ducksoo Kim, Yi Xu, Fei-Yun Wu, Samuel Han, Byung-Boong Lee, Lin-Sun Li 2016 University of Massachusetts Medical School

Redefining Budd-Chiari Syndrome: A Systematic Review, Naomi Shin, Young H. Kim, Hao Xu, Hai-Bin Shi, Qing-Qiao Zhang, Jean Paul Colon Pons, Ducksoo Kim, Yi Xu, Fei-Yun Wu, Samuel Han, Byung-Boong Lee, Lin-Sun Li

Radiology Publications

AIM: To re-examine whether hepatic vein thrombosis (HVT) (classical Budd-Chiari syndrome) and hepatic vena cava-Budd Chiari syndrome (HVC-BCS) are the same disorder.

METHODS: A systematic review of observational studies conducted in adult subjects with primary BCS, hepatic vein outflow tract obstruction, membranous obstruction of the inferior vena cava (IVC), obliterative hepatocavopathy, or HVT during the period of January 2000 until February 2015 was conducted using the following databases: Cochrane Library, CINAHL, MEDLINE, PubMed and Scopus.

RESULTS: Of 1299 articles identified, 26 were included in this study. Classical BCS is more common in women with a pure hepatic vein obstruction (49 ...


Redefining Budd-Chiari Syndrome: A Systematic Review, N. Shin, Y. Kim, H. Xu, H. Shi, Q. Zhang, Byung-Boong Lee, +6 additional authors 2016 George Washington University

Redefining Budd-Chiari Syndrome: A Systematic Review, N. Shin, Y. Kim, H. Xu, H. Shi, Q. Zhang, Byung-Boong Lee, +6 Additional Authors

Surgery Faculty Publications

AIM: To re-examine whether hepatic vein thrombosis (HVT) (classical Budd-Chiari syndrome) and hepatic vena cava-Budd Chiari syndrome (HVC-BCS) are the same disorder.

METHODS: A systematic review of observational studies conducted in adult subjects with primary BCS, hepatic vein outflow tract obstruction, membranous obstruction of the inferior vena cava (IVC), obliterative hepatocavopathy, or HVT during the period of January 2000 until February 2015 was conducted using the following databases: Cochrane Library, CINAHL, MEDLINE, PubMed and Scopus.

RESULTS: Of 1299 articles identified, 26 were included in this study. Classical BCS is more common in women with a pure hepatic vein obstruction (49 ...


Recipient Hyperbilirubinemia May Reduce Ischemia-Reperfusion Injury But Fails To Improve Outcome In Clinical Liver Transplantation, Mihai Oltean, Christian Barrenas, Paulo N.A. Martins, Gustaf Herlenius, Bengt Gustafsson, Styrbjorn Friman, William Bennet 2016 University of Gothenburg

Recipient Hyperbilirubinemia May Reduce Ischemia-Reperfusion Injury But Fails To Improve Outcome In Clinical Liver Transplantation, Mihai Oltean, Christian Barrenas, Paulo N.A. Martins, Gustaf Herlenius, Bengt Gustafsson, Styrbjorn Friman, William Bennet

Surgery Publications

Background. Exogenous bilirubin may reduce experimental ischemia-reperfusion injury (IRI) due to its antioxidant properties. We studied if early graft exposure to high bilirubin levels in the recipient affects the early IRI and outcomes after liver transplantation (LTx).

Methods. In 427 LTx patients, the AUROC curve based on bilirubin and AST at day 1 identified a cutoff of 2.04 mg/dL for the recipient pretransplant bilirubin. Recipients were grouped as having low (group L, n = 152) or high (group H, n = 275) bilirubin. Both groups had similar donor-related variables (age, preservation time, donor BMI > 28, and donor risk index (DRI ...


Adult Mouse Model Of Early Hepatocellular Carcinoma Promoted By Alcoholic Liver Disease, Aditya Ambade, Abhishek Satishchandran, Benedek Gyongyosi, Patrick Lowe, Gyongyi Szabo 2016 University of Massachusetts Medical School

Adult Mouse Model Of Early Hepatocellular Carcinoma Promoted By Alcoholic Liver Disease, Aditya Ambade, Abhishek Satishchandran, Benedek Gyongyosi, Patrick Lowe, Gyongyi Szabo

Open Access Articles

AIM: To establish a mouse model of alcohol-driven hepatocellular carcinoma (HCC) that develops in livers with alcoholic liver disease (ALD).

METHODS: Adult C57BL/6 male mice received multiple doses of chemical carcinogen diethyl nitrosamine (DEN) followed by 7 wk of 4% Lieber-DeCarli diet. Serum alanine aminotransferase (ALT), alpha fetoprotein (AFP) and liver Cyp2e1 were assessed. Expression of F4/80, CD68 for macrophages and Ly6G, MPO, E-selectin for neutrophils was measured. Macrophage polarization was determined by IL-1beta/iNOS (M1) and Arg-1/IL-10/CD163/CD206 (M2) expression. Liver steatosis and fibrosis were measured by oil-red-O and Sirius red staining respectively. HCC development ...


Lifestyle And Biological Risk Factors For Liver Fibrosis In The Miami Adult Studies On Hiv (Mash) Cohort: An Hiv Infected And Hiv/Hcv Co-Infected Population, Tiffanie S. Stewart 2016 Florida International University

Lifestyle And Biological Risk Factors For Liver Fibrosis In The Miami Adult Studies On Hiv (Mash) Cohort: An Hiv Infected And Hiv/Hcv Co-Infected Population, Tiffanie S. Stewart

FIU Electronic Theses and Dissertations

Liver disease is now a leading cause of non-AIDS related morbidity and mortality in people living with HIV (PLWH). The present study investigated the interplay between adverse lifestyle factors that are prevalent in PLWH, biological mediators of liver pathogenesis, and a non-invasive measure of liver fibrosis (FIB-4 index) in HIV mono- and HIV/HCV co-infected individuals.

The results of this investigation in the Miami Adult Studies of HIV (MASH) cohort show that the odds of liver fibrosis progression significantly increased over two years for HIV mono-infected participants who drank alcohol hazardously (OR 3.038, P=0.048), and had BMI ...


Cell-Free Circulating Mitochondrial Dna Content And Risk Of Hepatocellular Carcinoma In Patients With Chronic Hbv Infection., Ling Li, Hie-Won Hann, Shaogui Wan, Richard Hann, Chun Wang, Yinzhi Lai, Xishan Ye, Alison Evans, Ronald E. Myers, PhD, DSW, Zhong Ye, Bingshan Li, Jinliang Xing, Hushan Yang 2016 Division of Population Science, Department of Medical Oncology, Thomas Jefferson University

Cell-Free Circulating Mitochondrial Dna Content And Risk Of Hepatocellular Carcinoma In Patients With Chronic Hbv Infection., Ling Li, Hie-Won Hann, Shaogui Wan, Richard Hann, Chun Wang, Yinzhi Lai, Xishan Ye, Alison Evans, Ronald E. Myers, Phd, Dsw, Zhong Ye, Bingshan Li, Jinliang Xing, Hushan Yang

Department of Medicine Faculty Papers

Recent studies have demonstrated a potential link between circulating cell-free mitochondrial DNA (mtDNA) content and cancers. However, there is no study evaluating the association between circulating mtDNA as a non-invasive marker of hepatocellular carcinoma (HCC) risk. We conducted a nested case-control study to determine circulating mtDNA content in serum samples from 116 HBV-related HCC cases and 232 frequency-matched cancer-free HBV controls, and evaluate the retrospective association between mtDNA content and HCC risk using logistic regression and their temporal relationship using a mixed effects model. HCC cases had significantly lower circulating mtDNA content than controls (1.06 versus 2.47, P ...


Tissue- And Serum-Associated Biomarkers Of Hepatocellular Carcinoma, Ranjit Chauhan 2016 Loyola University Chicago

Tissue- And Serum-Associated Biomarkers Of Hepatocellular Carcinoma, Ranjit Chauhan

School of Medicine

Hepatocellular carcinoma (HCC), one of the leading causes of cancer deaths in the world, is offering a challenge to human beings, with the current modes of treatment being a palliative approach. Lack of proper curative or preventive treatment methods encouraged extensive research around the world with an aim to detect a vaccine or therapeutic target biomolecule that could lead to development of a drug or vaccine against HCC. Biomarkers or biological disease markers have emerged as a potential tool as drug/vaccine targets, as they can accurately diagnose, predict, and even prevent the diseases. Biomarker expression in tissue, serum, plasma ...


Immunomodulatory Roles Of Ctrp3 In Endotoxemia And Metabolic Stress, Jonathan M. Peterson, Risa M. Wolf, Xia Lei, G. William Wong 2016 John Hopkins University School of Medicine

Immunomodulatory Roles Of Ctrp3 In Endotoxemia And Metabolic Stress, Jonathan M. Peterson, Risa M. Wolf, Xia Lei, G. William Wong

Jonathan Peterson

C1q/TNF‐related protein 3 (CTRP3) is a secreted hormone that modulates hepatic glucose and lipid metabolism. Its circulating levels are reduced in human and rodent models of obesity, a metabolic state accompanied by chronic low‐grade inflammation. Recent studies have demonstrated an anti‐inflammatory role for recombinant CTRP3 in attenuating LPS‐induced systemic inflammation, and its deficiency markedly exacerbates inflammation in a mouse model of rheumatoid arthritis. We used genetic mouse models to explore the immunomodulatory function of CTRP3 in response to acute (LPS challenge) and chronic (high‐fat diet) inflammatory stimuli. In a sublethal dose of LPS challenge ...


Metabolic Profiling During Ex Vivo Machine Perfusion Of The Human Liver, Bote G. Bruinsma, Gautham V. Sridharan, Pepijn D. Weeder, James H. Avruch, Nima Saeidi, Sinan Ozer, Sharon Geerts, Robert J. Porte, Michal Heger, Thomas M. van Gulik, Paulo N.A. Martins, James F. Markmann, Heidi Yeh, Korkut Uygun 2016 Harvard Medical School

Metabolic Profiling During Ex Vivo Machine Perfusion Of The Human Liver, Bote G. Bruinsma, Gautham V. Sridharan, Pepijn D. Weeder, James H. Avruch, Nima Saeidi, Sinan Ozer, Sharon Geerts, Robert J. Porte, Michal Heger, Thomas M. Van Gulik, Paulo N.A. Martins, James F. Markmann, Heidi Yeh, Korkut Uygun

Surgery Publications

As donor organ shortages persist, functional machine perfusion is under investigation to improve preservation of the donor liver. The transplantation of donation after circulatory death (DCD) livers is limited by poor outcomes, but its application may be expanded by ex vivo repair and assessment of the organ before transplantation. Here we employed subnormothermic (21 degrees C) machine perfusion of discarded human livers combined with metabolomics to gain insight into metabolic recovery during machine perfusion. Improvements in energetic cofactors and redox shifts were observed, as well as reversal of ischemia-induced alterations in selected pathways, including lactate metabolism and increased TCA cycle ...


Alcoholic Hepatitis Accelerates Early Hepatobiliary Cancer By Increasing Stemness And Mir-122-Mediated Hif-1alpha Activation, Aditya Ambade, Abhishek Satishchandran, Gyongyi Szabo 2016 University of Massachusetts Medical School

Alcoholic Hepatitis Accelerates Early Hepatobiliary Cancer By Increasing Stemness And Mir-122-Mediated Hif-1alpha Activation, Aditya Ambade, Abhishek Satishchandran, Gyongyi Szabo

Open Access Articles

Alcohol-related hepatocellular carcinoma (HCC) develops with advanced alcoholic liver disease and liver fibrosis. Using adult mice, we evaluate the effect of alcoholic steatohepatitis on early hepatobiliary carcinoma after initiation by diethyl-nitrosamine (DEN). Here we show that alcohol-fed DEN-injected mice have higher ALT and liver-to-body weight ratio compared to pair-fed DEN-injected mice. Alcohol feeding results in steatohepatitis indicated by increased pro-inflammatory cytokines and fibrotic genes. MRI and liver histology of alcohol+DEN mice shows hepatobiliary cysts, early hepatic neoplasia and increase in serum alpha-fetoprotein. Proliferation makers (BrdU, cyclin D1, p53) and cancer stem cell markers (CD133 and nanog) are significantly up-regulated ...


Hepatitis C Virus-Induced Monocyte Differentiation Into Polarized M2 Macrophages Promotes Stellate Cell Activation Via Tgf-Beta, Banishree Saha, Karen Kodys, Gyongyi Szabo 2016 University of Massachusetts Medical School

Hepatitis C Virus-Induced Monocyte Differentiation Into Polarized M2 Macrophages Promotes Stellate Cell Activation Via Tgf-Beta, Banishree Saha, Karen Kodys, Gyongyi Szabo

UMass Metabolic Network Publications

BACKGROUND and AIMS: Monocyte and macrophage (MPhi) activation contributes to the pathogenesis of chronic hepatitis C virus (HCV) infection. Disease pathogenesis is regulated by both liver-resident MPhis and monocytes recruited as precursors of MPhis into the damaged liver. Monocytes differentiate into M1 (classic/proinflammatory) or M2 (alternative/anti-inflammatory) polarized MPhis in response to tissue microenvironment. We hypothesized that HCV-infected hepatoma cells (infected with Japanese fulminant hepatitis-1 [Huh7.5/JFH-1]) induce monocyte differentiation into polarized MPhis.

METHODS: Healthy human monocytes were co-cultured with Huh7.5/JFH-1 cells or cell-free virus for 7 days and analyzed for MPhi markers and cytokine levels ...


Vitamin D Deficiency Promotes Liver Tumor Growth In Transforming Growth Factor-Β/Smad3-Deficient Mice Through Wnt And Toll-Like Receptor 7 Pathway Modulation., Jian Chen, Lior H Katz, Nina M Muñoz, Shoujun Gu, Ji-Hyun Shin, Lopa Mishra, +13 additional authors 2016 George Washington University

Vitamin D Deficiency Promotes Liver Tumor Growth In Transforming Growth Factor-Β/Smad3-Deficient Mice Through Wnt And Toll-Like Receptor 7 Pathway Modulation., Jian Chen, Lior H Katz, Nina M Muñoz, Shoujun Gu, Ji-Hyun Shin, Lopa Mishra, +13 Additional Authors

Surgery Faculty Publications

Disruption of the TGF-β pathway is associated with liver fibrosis and suppression of liver tumorigenesis, conditions associated with low Vitamin D (VD) levels. However, potential contributions of VD to liver tumor progression in the context of TGF-β signaling remain unexplored. Our analyses of VD deprivation (VDD) in in vivo models of liver tumor formation revealed striking three-fold increases in tumor burden in Smad3(+/-) mice, with a three-fold increase in TLR7 expression compared to controls. ChIP and transcriptional assays confirm Smad3 binding at two TLR7 promoter SBE sites. Molecular interactions between TGF-β pathway and VDD were validated clinically, where an absence ...


Modulation Of Body Weight By Intestinal Flora In Orphan Nuclear Receptor Shp-/- Mice, Ryan Mifflin 2016 University of Akron

Modulation Of Body Weight By Intestinal Flora In Orphan Nuclear Receptor Shp-/- Mice, Ryan Mifflin

Williams Honors College, Honors Research Projects

The whole-body deletion of small heterodimer partner (SHP) in mice is associated with protection from diet-induced obesity and hepatic steatosis upon feeding of a western diet. This protection was reported to be mediated through decreases in hepatic gene expression for lipogenesis, as well as increases in gene expression for fatty acid oxidation. SHP has been known to regulate the expression of the CYP7A1 gene, encoding the rate-limiting enzyme for bile acid synthesis, thereby altering the bile acid pool. The effects of this altered bile acid profile on the gut microbiome are unknown, as some bacteria in the gut are responsible ...


Simeprevir Plus Sofosbuvir (12 And 8 Weeks) In Hepatitis C Virus Genotype 1-Infected Patients Without Cirrhosis: Optimist-1, A Phase 3, Randomized Study, P. Kwo, N. Gitlin, R. Nahass, D. Bernstein, K. Etzkorn, S. Rojter, E. Schiff, M. Davis, P. Ruane, J. Witek, +8 additional authors 2016 Zucker School of Medicine at Hofstra/Northwell

Simeprevir Plus Sofosbuvir (12 And 8 Weeks) In Hepatitis C Virus Genotype 1-Infected Patients Without Cirrhosis: Optimist-1, A Phase 3, Randomized Study, P. Kwo, N. Gitlin, R. Nahass, D. Bernstein, K. Etzkorn, S. Rojter, E. Schiff, M. Davis, P. Ruane, J. Witek, +8 Additional Authors

Journal Articles

No abstract provided.


Expression Of The Non-Structural Proteins Ns3/4a Of The Hepatitis C Virus Using A Genetically Modified Vesicular Stomatitis Virus Vector System, Angela Ye Seul Kim 2016 Western University

Expression Of The Non-Structural Proteins Ns3/4a Of The Hepatitis C Virus Using A Genetically Modified Vesicular Stomatitis Virus Vector System, Angela Ye Seul Kim

2016 Undergraduate Awards

Hepatitis C virus (HCV) infection is one of the leading causes of chronic liver diseases. Despite advancements in the development of antivirals and efforts to combat HCV infections, there is currently no vaccine for HCV. Adopting traditional approaches to HCV vaccine development has been impractical due to the lack of reproducible cell culture systems that can support HCV replication. In this study, the New Jersey serotype of recombinant vesicular stomatitis virus (rVSVNJ) was used as the vector to express non-structural proteins NS3/4A of genotype 1a HCV for potential vaccine purposes. The rVSVNJ-GMM vector was genetically modified by changing glycine ...


Should The Pharmacologic Management For Chronic Hepatitis C Encompass A Response Guided Therapy Treatment Plan?, Sarah Viscarra 2016 University of North Dakota

Should The Pharmacologic Management For Chronic Hepatitis C Encompass A Response Guided Therapy Treatment Plan?, Sarah Viscarra

Physician Assistant Scholarly Project Posters

Pharmacologic advances have been made with the development of new drug therapies that essentially cure the hepatitis C virus, such as sofosbuvir. The purpose of this study is to determine whether sofosbuvir should encompass a response guided therapy treatment plan versus a standard treatment protocol, in efforts to limit the risk of adverse effects and to minimize the cost of treatment. The systematic review of literature retrieved from Pub Med and Cochrane, explored studies that compared a standard treatment protocol of 12 weeks, in male and female adults ages 18-90 years, to response guided therapy treatment plans based on each ...


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