Neurology Commons^™

Conversion From Enzyme-Inducing Antiepileptic Drugs To Topiramate: Effects On Lipids And C-Reactive Protein., Scott Mintzer, Christopher T Skidmore, Sara J Rankin, Inna Chervoneva, Edward Pequinot, David M Capuzzi, Michael R Sperling

Department of Neurology Faculty Papers

PURPOSE: We previously demonstrated that converting patients from the enzyme-inducers phenytoin or carbamazepine to the non-inducers levetiracetam or lamotrigine reduces serum lipids and C-reactive protein (CRP). We sought to determine if the same changes would occur when patients were switched to topiramate, which has shown some evidence of enzyme induction at high doses. We also examined the effects of drug switch on low-density lipoprotein (LDL) particle concentration.

METHODS: We converted 13 patients from phenytoin or carbamazepine monotherapy to topiramate monotherapy (most at doses of 100-150 mg/day). Fasting lipids, including LDL particle concentration, and CRP were obtained before and ≥6 weeks …

Investigating The Impact Of Cd147 And Its Expression On Neurodegenaration And Alzheimer's Disease (Ad), Limbikani J. Kanyenda

Theses: Doctorates and Masters

CD147, also known as basigin, extracellular matrix metalloproteinase inducer, neurothelin, tumour cell-derived collagenase stimulatory factor, M6, HT7, OX47 or gp42, is a transmembrane glycoprotein of the immunoglobulin super-family. It is expressed in many neuronal and non-neuronal tissues with high expression in the hippocampus, pre-frontal cortex, thyroid, heart, early erythroid, amygdala and placenta. This protein is involved in various cellular and biological functions such as lymphocyte migration and maturation, tissue repair, cancer progression, T and B lymphocyte activation and induction of extracellular matrix metalloproteinase. The CD147 protein interacts with with cyclophilin A, cyclophilin B, sterol carrier protein, caveolin-1 and integrins, and …

Multimodal Imaging Evidence For Axonal And Myelin Deterioration In Amnestic Mild Cognitive Impairment, Brian T. Gold, Yang Jiang, David K. Powell, Charles D. Smith

Neuroscience Faculty Publications

White matter (WM) microstructural declines have been demonstrated in Alzheimer's disease and amnestic mild cognitive impairment (aMCI). However, the pattern of WM microstructural changes in aMCI after controlling for WM atrophy is unknown. Here, we address this issue through joint consideration of aMCI alterations in fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity, as well as macrostructural volume in WM and gray matter compartments. Participants were 18 individuals with aMCI and 24 healthy seniors. Voxelwise analyses of diffusion tensor imaging data was carried out using tract-based spatial statistics (TBSS) and voxelwise analyses of high-resolution structural data was conducted using …

Elderly Onset Of Weakness In Facioscapulohumeral Muscular Dystrophy, Dominic B. Fee

Neurology Faculty Publications

A 77-year-old male is presented. He had onset of proximal weakness 10 years earlier. His course was slowly progressive. Despite having phenotypic features of facioscapulohumeral muscular dystrophy (FSH), genetic testing for this was delayed because of his age of onset, lack of family history, and benign appearing muscle biopsy. This case is one of the oldest onset of weakness in genetically confirmed FSH and highlights the recognized expansion in phenotype that has occurred since the advent of genetic testing.

Beyond Traditional Notions Of Validity: Selecting Appropriate Measures For Occupational Therapy Practice., Andrew Johnson, Briana Zur, Eric Roy, Debbie Laliberte-Rudman, Jennie Wells

Andrew M. Johnson

Increasingly, tied to factors such as increased emphasis on accountability and health care spending restraints, occupational therapists are required to implement evidence-based practice. When implementing evidence-based assessment, it is critical that occupational therapists examine and challenge some of the assumptions underlying the current use of measures, as well as the conclusions being drawn from their use. In order to most effectively judge the appropriateness of measures informing their assessments, interventions and recommendations, occupational therapists must draw upon measurement theory and concepts. To date, occupational therapy literature has predominantly emphasized a narrow conceptualization of validity that focuses on empirical evidence. The …

A Prospective Study Of Physician-Observed Concussion During A Varsity University Hockey Season: Incidence And Neuropsychological Changes, Paul Echlin, Elaine Skopelja, Rachel Worsley, Shiroy Dadanchanji, Rob Lloyd-Smith, Jack Taunton, Lorie Forwell, Andrew Johnson

Andrew M. Johnson

Object. The primary objective of this study was to measure the incidence of concussion according to a relative number of athlete exposures among 25 male and 20 female varsity ice hockey players. The secondary objective was to present neuropsychological test results between preseason and postseason play and at 72 hours, 2 weeks, and 2 months after concussion. Methods. Every player underwent baseline assessments using the Sport Concussion Assessment Tool-2 (SCAT2), Immediate Post-Concussion Assessment and Cognitive Test (ImPACT), and MRI. Each regular season and postseason game was observed by 2 independent observers (a physician and a nonphysician observer). Players with a …

A Prospective Study Of Physician-Observed Concussion During A Varsity University Hockey Season: Metabolic Changes In Ice Hockey Players., Emilie Chamard, Hugo Theoret, Elaine Skopelja, Lorie Forwell, Andrew Johnson, Paul Echlin

Andrew M. Johnson

Object. Despite negative neuroimaging findings using traditional neuroimaging methods such as MRI and CT, sports-related concussions have been shown to cause neurometabolic changes in both the acute and subacute phases of head injury. However, no prospective clinical study has used an independent physician-observer design in the monitoring of these changes. The objective of this study was to evaluate the effects of repetitive concussive and subconcussive head impacts on neurometabolic concentrations in a prospective study of two Canadian Interuniversity Sports (CIS) ice hockey teams using MR spectroscopy (MRS). Methods. Forty-five ice hockey players (25 men and 20 women) participated in this …

A Prospective Study Of Physician-Observed Concussion During A Varsity University Hockey Season: White Matter Integrity In Ice Hockey Players, Inga Koerte, David Kaufmann, Elisabeth Hartl, Sylvain Bouix, Ofer Pasternak, Marek Kubicki, Alexander Rauscher, David Li, Shiroy Dadachanji, Jack Taunton, Lorie Forwell, Andrew Johnson, Paul Echlin, Martha Shenton

Andrew M. Johnson

Object. The aim of this study was to investigate the effect of repetitive head impacts on white matter integrity that were sustained during 1 Canadian Interuniversity Sports (CIS) ice hockey season, using advanced diffusion tensor imaging (DTI). Methods. Twenty-five male ice hockey players between 20 and 26 years of age (mean age 22.24 ± 1.59 years) participated in this study. Participants underwent pre- and postseason 3-T MRI, including DTI. Group analyses were performed using paired-group tract-based spatial statistics to test for differences between preseason and postseason changes. Results. Tract-based spatial statistics revealed an increase in trace, radial diffusivity (RD), and …

Bilateral Medial Medullary Infarction: A Systematic Review, Gustavo Saposnik

Gustavo Saposnik

No abstract provided.

Unmasking The Benefits Of B Vitamins In Stroke Prevention, Gustavo Saposnik

Gustavo Saposnik

No abstract provided.

A Critical Analysis Of The Current State Of Neurosurgery Training In Pakistan, Muhammad Shahzad Shamim, Muhammad Zubair Tahir, Saniya Siraj Godil, Rajesh Kumar, Arshad Ali Siddiqui

Section of Neurosurgery

Objective: To observe interdepartmental variation in the availability of resources and academic activities within the various neurosurgery programs of Pakistan.
Methods: This was a proforma-based survey of neurosurgery trainees and young neurosurgeons of Pakistan, looking at the academic infrastructure and output of their programs. The proforma was filled by 36 respondents from 11 neurosurgery centers of the country. All these centers were accredited for neurosurgery training in Pakistan.
Results: Out of the 36 respondents, 30 were completing a Fellowship training (FCPS) and six were enrolled for a Master in Surgery (MS) program. About 80% of the participants used the Youman's …

Cerebrospinal Fluid Rhinorrhea: An Institutional Perspective From Pakistan, Muhammad Zubair Tahir, Muhammad Babar Khan, Muhammad Umair Bashir, Shabbir Akhtar, Muhammad Ehsan Bari

Section of Neurosurgery

Background:The management of cerebrospinal fluid (CSF) rhinorrhea has evolved over the last two decades. We present here a review of our 11-year data on CSF rhinorrhea and its management at a tertiary care hospital in a developing country, with particular reference to the diagnosis, surgical management and outcome of the disease.
Methods: The medical charts of all Patients with a diagnosis of CSF rhinorrhea over an 11-year period were reviewed. The etiology of CSF rhinorrhea was classified into three categories: spontaneous, iatrogenic and traumatic. All the Patients were divided into three categories based on the type of management as …

Jean-Martin Charcot - Neurologist By Avocation, Nephrologist By Yearning, Gary Eknoyan

Houston History of Medicine Lectures

In an age of medical advances and specialization, Jean-Martin Charcot (1825-1893) helped found the discipline of neurology and in 1882 was appointed the first professor of Diseases of the Nervous System in France. As an investigator with broad interests and vast knowledge Charcot contributed to several other disciplines. An early mentor and dominant figure in Charcot's formative years was Pierre Rayer (1793-1867), famous for his seminal contributions to the study of the kidney, who gifted Charcot with his passion for clinical pathological correlations and likely a yearning for the study of kidney diseases. Famous for the clarity and incisiveness of …

Variations In Practice Patterns Among Neurosurgeons And Orthopaedic Surgeons In The Management Of Spinal Disorders, Manzar Hussain, Sadaf Nasir, Amber Moed, Ghulam Murtaza

Section of Neurosurgery

Study design: This is a case series.
Purpose: We wanted to identify variations in the practice patterns among neurosurgeons and orthopedic surgeons for the management of spinal disorders.
Overview of literature: Spinal disorders are common in the clinical practice of both neurosurgeons and orthopedic surgeons. It has been observed that despite the availability of various guidelines, there is lack of consensus among surgeons about the management of various disorders.
Methods: A questionnaire was distributed, either directly or via e-mail, to the both the neurosurgeons and orthopedic surgeons who worked at 5 tertiary care centers within a single region of Korea. …

Biotinidase Deficiency- A Treatable Inherited Metabolic Disorder, Bushra Afroze

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

Ambulatory Blood Pressure Monitoring In Stroke Survivors: What Do We Add To The Care Of Our Patients?, Shaista Anwar Siddiqi, Ayeesha Kamran Kamal

Department of Medicine

No abstract provided.

Ambulatory Blood Pressure Monitoring In Stroke Survivors: What Do We Add To The Care Of Our Patients, Shaista Anwar Siddiqi, Ayeesha Kamran Kamal

Section of Neurology

No abstract provided.

Pediatric Neurology In The 21st Century: Its Outlook In Pakistan, Shahnaz Ibrahim

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

Baseline Profile Of Childhood Focal Epilepsies In Jordan, Wael Hayel Khreisat

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

Dural Sinus Thrombosis A Local Experience At Shifa International Hospital, Islamabad, Pakistan, Maimoona Siddiqui, Nadia Mehboob, Ismail A. Khatri

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.