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Transcriptomics Of Gabra4 Knockout Mice Reveals Common Nmdar Pathways Underlying Autism, Memory, And Epilepsy, Cuixia Fan, Yue Gao, Guanmei Liang, Lang Huang, Jing Wang, Xiaoxue Yang, Yiwu Shi, Ursula C. Drager, Mei Zhong, Tian-Ming Gao, Xinping Yang 2020 Southern Medical University

Transcriptomics Of Gabra4 Knockout Mice Reveals Common Nmdar Pathways Underlying Autism, Memory, And Epilepsy, Cuixia Fan, Yue Gao, Guanmei Liang, Lang Huang, Jing Wang, Xiaoxue Yang, Yiwu Shi, Ursula C. Drager, Mei Zhong, Tian-Ming Gao, Xinping Yang

Open Access Publications by UMMS Authors

Autism spectrum disorder (ASD) is a neuronal developmental disorder with impaired social interaction and communication, often with abnormal intelligence and comorbidity with epilepsy. Disturbances in synaptic transmission, including the GABAergic, glutamatergic, and serotonergic systems, are known to be involved in the pathogenesis of this disorder, yet we do not know if there is a common molecular mechanism. As mutations in the GABAergic receptor subunit gene GABRA4 are reported in patients with ASD, we eliminated the Gabra4 gene in mice and found that the Gabra4 knockout mice showed autistic-like behavior, enhanced spatial memory, and attenuated susceptibility to pentylenetetrazol-induced seizures, a constellation ...


Rivastigmine Modifies The Α-Secretase Pathway And Potentially Early Alzheimer's Disease, Balmiki Ray, Bryan Maloney, Kumar Sambamurti, Hanuma K. Karnati, Peter T. Nelson, Nigel H. Greig, Debomoy K. Lahiri 2020 Indiana University

Rivastigmine Modifies The Α-Secretase Pathway And Potentially Early Alzheimer's Disease, Balmiki Ray, Bryan Maloney, Kumar Sambamurti, Hanuma K. Karnati, Peter T. Nelson, Nigel H. Greig, Debomoy K. Lahiri

Sanders-Brown Center on Aging Faculty Publications

Rivastigmine (or Exelon) is a cholinesterase inhibitor, currently used as a symptomatic treatment for mild-to-moderate Alzheimer’s disease (AD). Amyloid-β peptide (Aβ) generated from its precursor protein (APP) by β-secretase (or BACE1) and γ-secretase endoproteolysis. Alternative APP cleavage by α-secretase (a family of membrane-bound metalloproteases– Adamalysins) precludes the generation of toxic Aβ and yields a neuroprotective and neurotrophic secreted sAPPα fragment. Several signal transduction pathways, including protein kinase C and MAP kinase, stimulate α-secretase. We present data to suggest that rivastigmine, in addition to anticholinesterase activity, directs APP processing away from BACE1 and towards α-secretases. We treated rat neuronal PC12 ...


Treatment And Management Of Depression Symptoms In Pregnant Veterans: Varying Experiences Of Mental Health Care In The Prenatal Period, Aimee Kroll-Desrosiers, Sybil L. Crawford, Tiffany A. Moore Simas, Melissa A. Clark, Kristin M. Mattocks 2020 University of Massachusetts Medical School

Treatment And Management Of Depression Symptoms In Pregnant Veterans: Varying Experiences Of Mental Health Care In The Prenatal Period, Aimee Kroll-Desrosiers, Sybil L. Crawford, Tiffany A. Moore Simas, Melissa A. Clark, Kristin M. Mattocks

Population and Quantitative Health Sciences Publications

Depression screening is recommended for all pregnant veterans; however, little is known on how often symptomatic women receive care, how depression treatment presents in practice, and whether women veterans are utilizing treatment during the appreciable perinatal period. Our sample included 142 pregnant veterans from 15 Veterans Health Administration (VA) medical facilities with Edinburgh Postnatal Depression Scale (EPDS) scores >/=10. Sociodemographic characteristics, military service, health utilization, and pregnancy related factors were collected as part of a telephone survey. A majority of our sample (70%) had 1 or more mental health visits or antidepressant prescriptions during pregnancy. Women with a history of ...


Toward Actionable Practice Parameters For "Dual Diagnosis": Principles Of Assessment And Management For Co-Occurring Psychiatric And Intellectual/Developmental Disability., John N. Constantino, Shae Strom, Michael Bunis, Cy Nadler, Teresa Rodgers, Julia LePage, Connie Cahalan, Amber Stockreef, Lucas Evans, Rachel Jones, Alyssa Wilson 2020 Children's Mercy Hospital

Toward Actionable Practice Parameters For "Dual Diagnosis": Principles Of Assessment And Management For Co-Occurring Psychiatric And Intellectual/Developmental Disability., John N. Constantino, Shae Strom, Michael Bunis, Cy Nadler, Teresa Rodgers, Julia Lepage, Connie Cahalan, Amber Stockreef, Lucas Evans, Rachel Jones, Alyssa Wilson

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE OF REVIEW: Although treatment algorithms and parameters for best practice are readily available for all major syndromes of psychiatric impairment, the occurrence of psychiatric syndromes in individuals with intellectual and developmental disability (IDD) invokes serious contextual challenges for interpretation of symptoms, diagnosis, and optimization of treatment, both for clinicians and for the service sectors in which care and support of individuals with IDD are delivered. Recognizing that there exist very few definitive resources for best practice under the circumstance of this form of "dual diagnosis," the Missouri Department of Mental Health convened an expert panel to conduct a focused ...


A Phantom Of The Past: Withdrawal From Meprobamate Presenting With Focal Seizures., Thomas M. Zink, John E. Erickson 2020 Tufts University School of Medicine; Maine Medical Center

A Phantom Of The Past: Withdrawal From Meprobamate Presenting With Focal Seizures., Thomas M. Zink, John E. Erickson

Journal of Maine Medical Center

Introduction: Meprobamate (Miltown, Equinil) is a sedative-hypnotic medication that first gained popularity as an anxiolytic and later as a muscle relaxant. It is a major metabolite of the more commonly used muscle relaxant carisoprodol (Soma). In vitro and electroencephalogram studies demonstrated that meprobamate modulates gama-aminobutyric acid (GABA) receptors, similar to barbiturates. Withdrawal from meprobamate manifests in symptoms ranging from mild anxiety to severe autonomic instability and death. Meprobamate is rarely prescribed, but is still given to a small subset of elderly patients.

Clinical findings: In this case of meprobamate withdrawal, the patient initially displayed altered mental status and recurrent seizures ...


Anxiety And Depressive Symptoms Pre-Trauma As A Predictor Of Dissociative Symptoms Post-Trauma – An Aurora Study, Vishal Swaminathan 2020 Thomas Jefferson University

Anxiety And Depressive Symptoms Pre-Trauma As A Predictor Of Dissociative Symptoms Post-Trauma – An Aurora Study, Vishal Swaminathan

Phase 1

Introduction: Increased states of anxiety or depression may lead to increased occurrences of dissociative behavior, justifying the need to validate pre-traumatic cognitive states as a predictor of dissociation post-trauma. Early prediction can lead to medical intervention for high-risk patients and prevent potential adverse sequalae. The AURORA Study evaluates biomarkers and neuropsychological sequelae in patients immediately following traumatic events. We predict patients who suffered from depressive symptoms and anxiety prior to the traumatic event will experience increased dissociative symptoms post-trauma.

Methods: This study includes survey data collected at ED’s from survivors (n = 666) of traumatic motorized vehicle collisions (MVC) at ...


Working With Bipolar Disorder During The Covid-19 Pandemic: Both Crisis And Opportunity, E. A. Youngstrom, S. P. Hinshaw, A. Stefana, J. Chen, K. Michael, A. Van Meter, V. Maxwell, E. E. Michalak, E. G. Choplin, E. Vieta, +3 additional authors 2020 Zucker School of Medicine at Hofstra/Northwell

Working With Bipolar Disorder During The Covid-19 Pandemic: Both Crisis And Opportunity, E. A. Youngstrom, S. P. Hinshaw, A. Stefana, J. Chen, K. Michael, A. Van Meter, V. Maxwell, E. E. Michalak, E. G. Choplin, E. Vieta, +3 Additional Authors

Journal Articles

© 2020, WikiJournal User Group. All rights reserved. Beyond public health and economic costs, the COVID-19 pandemic adds strain, disrupts daily routines, and com-plicates mental health and medical service delivery for those with mental health and medical conditions. Bipolar disorder can increase vulnerability to infection; it can also enhance stress, complicate treatment, and heighten interpersonal stigma. Yet there are successes when people proactively improve social connections, prioritize self-care, and learn to use mobile and telehealth effectively.


Covid-19 Psychosis: A Potential New Neuropsychiatric Condition Triggered By Novel Coronavirus Infection And The Inflammatory Response?, S. J. Ferrando, L. Klepacz, S. Lynch, M. Tavakkoli, R. Dornbush, R. Baharani, Y. Smolin, A. Bartell 2020 Northwell Health

Covid-19 Psychosis: A Potential New Neuropsychiatric Condition Triggered By Novel Coronavirus Infection And The Inflammatory Response?, S. J. Ferrando, L. Klepacz, S. Lynch, M. Tavakkoli, R. Dornbush, R. Baharani, Y. Smolin, A. Bartell

Journal Articles

No abstract provided.


Response To Sars-Covid-19-Related Visitor Restrictions On Labor And Delivery Wards In New York City, A Hermann, KM Deligiannidis, V Bergink, C Monk, EM Fitelson, TK Robakis, C Birndorf 2020 Zucker School of Medicine at Hofstra/Northwell

Response To Sars-Covid-19-Related Visitor Restrictions On Labor And Delivery Wards In New York City, A Hermann, Km Deligiannidis, V Bergink, C Monk, Em Fitelson, Tk Robakis, C Birndorf

Journal Articles

No abstract provided.


How Mental Health Care Should Change As A Consequence Of The Covid-19 Pandemic, C. Moreno, T. Wykes, S. Galderisi, M. Nordentoft, N. Crossley, N. Jones, M. Cannon, C. U. Correll, L. Byrne, C. Arango, +14 additional authors 2020 Zucker School of Medicine at Hofstra/Northwell

How Mental Health Care Should Change As A Consequence Of The Covid-19 Pandemic, C. Moreno, T. Wykes, S. Galderisi, M. Nordentoft, N. Crossley, N. Jones, M. Cannon, C. U. Correll, L. Byrne, C. Arango, +14 Additional Authors

Journal Articles

No abstract provided.


Safety Of Psychotropic Medications In People With Covid-19: Evidence Review And Practical Recommendations, G Ostuzzi, D Papola, C Gastaldon, G Schoretsanitis, F Bertolini, F Amaddeo, A Cuomo, R Emsley, C U. Correll, C Barbui, +12 additional authors 2020 Zucker School of Medicine at Hofstra/Northwell

Safety Of Psychotropic Medications In People With Covid-19: Evidence Review And Practical Recommendations, G Ostuzzi, D Papola, C Gastaldon, G Schoretsanitis, F Bertolini, F Amaddeo, A Cuomo, R Emsley, C U. Correll, C Barbui, +12 Additional Authors

Journal Articles

No abstract provided.


Covid-19 Epidemic Peer Support And Crisis Intervention Via Social Media, P Cheng, G Xia, P Pang, B Wu, W Jiang, Y-T Li, M Wang, Q Ling, X Chang, X Bi, +3 additional authors 2020 Zucker School of Medicine at Hofstra/Northwell

Covid-19 Epidemic Peer Support And Crisis Intervention Via Social Media, P Cheng, G Xia, P Pang, B Wu, W Jiang, Y-T Li, M Wang, Q Ling, X Chang, X Bi, +3 Additional Authors

Journal Articles

No abstract provided.


Pharmacological Treatment Of Hyperactive Delirium In People With Covid-19: Rethinking Conventional Approaches, G. Ostuzzi, C. Gastaldon, D. Papola, A. Fagiolini, S. Dursun, D. Taylor, C. U. Correll, C. Barbui 2020 Zucker School of Medicine at Hofstra/Northwell

Pharmacological Treatment Of Hyperactive Delirium In People With Covid-19: Rethinking Conventional Approaches, G. Ostuzzi, C. Gastaldon, D. Papola, A. Fagiolini, S. Dursun, D. Taylor, C. U. Correll, C. Barbui

Journal Articles

No abstract provided.


The Efficacy Of Yoga As An Adjunctive Therapy To Standard Multidisciplinary Care In The Treatment Of Female Patients Presenting With Cognitive Eating Disorder Symptoms, Cassidy Nagle 2020 Arcadia University

The Efficacy Of Yoga As An Adjunctive Therapy To Standard Multidisciplinary Care In The Treatment Of Female Patients Presenting With Cognitive Eating Disorder Symptoms, Cassidy Nagle

Capstone Showcase

Introduction: Current treatment of patients exhibiting cognitive eating disorder symptoms is standard multidisciplinary care (SMDC) involving behavioral therapy, medical management and dietetics. Because these symptoms often persist or relapse despite treatment, research has begun to explore adjunctive therapies like yoga for this population. This review will explore seven studies in order to analyze the effect of yoga (I) on cognitive eating disorder symptoms (O) in teenage and adult females (P) when added to SMDC compared to symptom reduction with SMDC alone (C).

Methods: A literature search was conducted in PubMed, Academic Search Ultimate and Google Scholar starting November 2018. Seven ...


Functional Neuroimaging In Psychiatry-Aiding In Diagnosis And Guiding Treatment. What The American Psychiatric Association Does Not Know., Theodore A Henderson, Muriel J van Lierop, Mary McLean, John Michael Uszler, John F Thornton, Yin-Hui Siow, Dan G Pavel, Joe Cardaci, Phil Cohen 2020 Nuclear Medicine, Providence St. John's Health Center, Santa Monica, CA, United States.

Functional Neuroimaging In Psychiatry-Aiding In Diagnosis And Guiding Treatment. What The American Psychiatric Association Does Not Know., Theodore A Henderson, Muriel J Van Lierop, Mary Mclean, John Michael Uszler, John F Thornton, Yin-Hui Siow, Dan G Pavel, Joe Cardaci, Phil Cohen

Articles, Abstracts, and Reports

While early efforts in psychiatry were focused on uncovering the neurobiological basis of psychiatric symptoms, they made little progress due to limited ability to observe the living brain. Today, we know a great deal about the workings of the brain; yet, none of this neurobiological awareness has translated into the practice of psychiatry. The categorical system which dominates psychiatric diagnosis and thinking fails to match up to the real world of genetics, sophisticated psychological testing, and neuroimaging. Nevertheless, the American Psychiatric Association (APA) recently published a position paper stating that neuroimaging provided no benefit to the diagnosis and treatment of ...


Electroconvulsive Therapy Practice Changes In Older Individuals Due To Covid-19: Expert Consensus Statement, M. I. Lapid, S. Seiner, H. Heintz, A. P. Hermida, L. Nykamp, S. N. Sanghani, M. Mueller, G. Petrides, B. P. Forester 2020 Zucker School of Medicine at Hofstra/Northwell

Electroconvulsive Therapy Practice Changes In Older Individuals Due To Covid-19: Expert Consensus Statement, M. I. Lapid, S. Seiner, H. Heintz, A. P. Hermida, L. Nykamp, S. N. Sanghani, M. Mueller, G. Petrides, B. P. Forester

Journal Articles

© 2020 American Association for Geriatric Psychiatry The ubiquitous coronavirus 2019 (COVID-19) pandemic has required healthcare providers across all disciplines to rapidly adapt to public health guidelines to reduce risk while maintaining quality of care. Electroconvulsive therapy (ECT), which involves an aerosol-generating procedure from manual ventilation with a bag mask valve while under anesthesia, has undergone drastic practice changes in order to minimize disruption of treatment in the midst of COVID-19. In this paper, we provide a consensus statement on the clinical practice changes in ECT specific to older adults based on expert group discussions of ECT practitioners across the country ...


Correction To: Safety Of Psychotropic Medications In People With Covid-19: Evidence Review And Practical Recommendations (Vol 18, 215, 2020), G. Ostuzzi, D. Papola, C. Gastaldon, G. Schoretsanitis, F. Bertolini, F. Amaddeo, A. Cuomo, R. Emsley, C. U. Correll, C. Barbui, +12 additional authors 2020 Northwell Health

Correction To: Safety Of Psychotropic Medications In People With Covid-19: Evidence Review And Practical Recommendations (Vol 18, 215, 2020), G. Ostuzzi, D. Papola, C. Gastaldon, G. Schoretsanitis, F. Bertolini, F. Amaddeo, A. Cuomo, R. Emsley, C. U. Correll, C. Barbui, +12 Additional Authors

Journal Articles

No abstract provided.


Patient Attitudes Toward Telepsychiatry During The Covid-19 Pandemic: A Nationwide, Multisite Survey., D. Guinart, P. Marcy, M. Hauser, M. Dwyer, J. M. Kane 2020 Northwell Health

Patient Attitudes Toward Telepsychiatry During The Covid-19 Pandemic: A Nationwide, Multisite Survey., D. Guinart, P. Marcy, M. Hauser, M. Dwyer, J. M. Kane

Journal Articles

Background

The COVID-19 pandemic and its associated movement restrictions forced a rapid and massive transition to telepsychiatry to successfully maintain care continuity.

Objective

The aim of this study is to examine a large number of patients' experiences of, use of, and attitudes toward telepsychiatry.

Methods

An anonymous 11-question survey was delivered electronically to 14,000 patients receiving telepsychiatry care at 18 participating centers across 11 US states between the months of April and June 2020, including questions about their age and length of service use, as well as experience and satisfaction with telepsychiatry on a 5-point Likert scale. Descriptive statistics ...


Quetiapine And Wolff-Parkinson-White Syndrome, Michael Chen, Hassaan Gomaa, Alonso Cortez-Resendiz, Christopher Martin, Andrew Francis, Alfredo Bellon 2020 Lehigh Valley Health Network

Quetiapine And Wolff-Parkinson-White Syndrome, Michael Chen, Hassaan Gomaa, Alonso Cortez-Resendiz, Christopher Martin, Andrew Francis, Alfredo Bellon

Department of Psychiatry and Human Behavior Faculty Papers

Quetiapine is occasionally associated with cardiovascular adverse effects such as QTc prolongation. QTc prolongation is a side effect that requires monitoring in order to avoid more serious cardiac complications. One particular understudied area is the potential for antipsychotics to elicit electroconduction abnormalities in patients with Wolff-Parkinson-White (WPW) Syndrome. In the present report, we describe a case of quetiapine overdose in a patient with WPW.


The Efficacy Of Ketamine In Adult Patients With Obsessive Compulsive Disorder With Symptoms Refractory To Standard Of Care Treatment., Brooke Thornton 2020 Arcadia University

The Efficacy Of Ketamine In Adult Patients With Obsessive Compulsive Disorder With Symptoms Refractory To Standard Of Care Treatment., Brooke Thornton

Capstone Showcase

First line pharmacologic treatments for adult patients with Obsessive Compulsive Disorder (OCD) involve selective serotonin/norepinephrine reuptake inhibitors (SSRI/SNRIs). These drug classes often fail to deliver timely relief of symptoms as well as maintain longevity of symptom recurrence. This research analyzed the use of ketamine in adult patients suffering with OCD for the purposes of more efficacious management of symptoms. Although ketamine demonstrated a timelier relief of symptoms in some small clinical studies, its effects were ultimately unable to be sustained long term. Additionally, a wide range of adverse effects including dissociation, and rebound symptoms were observed. As a ...


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