Physiology, Rem Sleep, 2021 University of Massachusetts Medical School
Physiology, Rem Sleep, Joshua Feriante, John F. Araujo
Open Access Publications by UMMS Authors
Sleep is a reversible state of disconnection from the environment, including reduced consciousness, skeletal muscle mobility, and metabolism. All forms of sensory responses are markedly decreased to varying degrees depending on the sleep cycle stage. Although this phenomenon is observed in all species that have been studied and occupies a significant fraction of the human lifespan, the purpose and function of sleep remain poorly understood.
Sleep is measured primarily by polysomnography (PSG) which is considered the gold standard for diagnosing sleep disorders.. PSG reveals that sleep architecture has several distinct stages that vacillate between the non-rapid eye movement (NREM) stages ...
The Effect Of Cpap Treatment On T2dm In Moderate To Severe Osa Subjects, 2021 Thomas Jefferson University
The Effect Of Cpap Treatment On T2dm In Moderate To Severe Osa Subjects, Dani Yellanki, Amy He, Grace Severance, Peter Zhang, Zach Feuer, Natali Salinas, Olivia Taylor, Rani Patel, Hannah Kostan, Carl Sun, Catherine Liu, Humaal Khan, Katie Keck, Mikayla Cochrane, Ronak Ahir, Sammy Alfonsi, Will Connolly, Cynthia Cheng, Md, Phd
Introduction: Obstructive sleep apnea (OSA) is a significant risk factor for type 2 diabetes mellitus (T2DM). CPAP treatment can potentially improve glycemic control in such subjects. However, the exact effects of CPAP treatment on diabetes are uncertain. The objective of this study is to examine the effect of CPAP treatment on HbA1c levels in subjects with moderate to severe OSA and T2DM.
Methods: This is a combined retrospective and prospective study collecting data through EPIC medical record reviews. We are collecting HbA1c levels (primary outcome variable) before and after CPAP treatment in subjects with moderate to severe OSA and T2DM ...
Effects Of Continuous Positive Airway Pressure On Blood Pressure In Obstructive Sleep Apnea, 2021 Thomas Jefferson University
Effects Of Continuous Positive Airway Pressure On Blood Pressure In Obstructive Sleep Apnea, Amy He, Dani Yellanki, Grace Severance, Peter Zhang, Zachary Feuer, Natali Salinas, Cynthia Cheng, Md, Phd
Obstructive sleep apnea (OSA) has been previously linked to the development of hypertension, possibly through the proposed mechanism of recurrent episodes of intermittent hypoxia leading to endothelial dysfunction, inflammation, and metabolic dysregulation. This study aims to investigate continuous positive airway pressure (CPAP) therapy, a first-line therapy for OSA, and its effects on blood pressure in patients with moderate to severe OSA. We hypothesize that compliance to CPAP leads to a decrease in average annual systolic and diastolic blood pressure, compared to noncompliant and non-CPAP use.
Our study is a combined retrospective and prospective EPIC chart review study. Moderate ...
Usage Of Sleep Domain Of Snot-22 Scores In Screening For Osa In Patients Of Chronic Rhinosinusitis., 2021 Thomas Jefferson University
Usage Of Sleep Domain Of Snot-22 Scores In Screening For Osa In Patients Of Chronic Rhinosinusitis., Patrick Zhu, Mindy Rabinowitz, Md
Introduction: SNOT-22 is a screening tool universally applied in perioperative settings for endoscopic sinus surgery (ESS), typically for chronic rhinosinusitis (CRS). Comorbid obstructive sleep apnea (OSA) increases risk of perioperative complications following ESS, yet pre-ESS OSA screening is not performed. This study sought to determine whether the sleep subdomain SNOT-22 (SD-SNOT) score could be useful for OSA screening.
Methods: A retrospective study was performed by reviewing electronic records of 108 patients that underwent endoscopic sinus surgery between November 2019 – January 2020. Pre-operative and 2 months post-operative SD-SNOT scores were compared with the presence or absence of OSA.
Results: Mean sleep ...
Effects Of Continuous Positive Airway Pressure (Cpap) Sleep Apnea Treatment On Mild Cognitive Impairment (Mci) And Cardiovascular Risk, 2021 Thomas Jefferson University
Effects Of Continuous Positive Airway Pressure (Cpap) Sleep Apnea Treatment On Mild Cognitive Impairment (Mci) And Cardiovascular Risk, Olivia Taylor, Cynthia Cheng, Md, Phd
There is a documented association between sleep apnea and earlier onset of cognitive impairment later in life. We hypothesize that nightly treatment with CPAP therapy will improve MCI status as estimated by a panel of neuropsychiatry tests in patients >55 with OSA and concomitant memory complaints. With a prospective cohort design, patients compliant with CPAP therapy are being compared to noncompliant patients and a non-OSA control group. My role in this multi-site project was to screen potential patients from Jefferson’s sleep clinic for eligibility for study enrollment. This study is still ongoing. OSA’s high prevalence makes it a ...
Prevalence And Risk Factors For Abnormal M-Tics, 2021 Thomas Jefferson University
Prevalence And Risk Factors For Abnormal M-Tics, Maëlys Yepes, Michael Chang, Cynthia Cheng, Md, Phd
Introduction: The lack of effective treatments for Alzheimer’s Disease (AD) underscores the importance of prevention and early detection of amnestic mild cognitive impairment (aMCI), its prodromal state. While studies have proposed a number of potential mechanisms underlying the pathogenesis of AD, such as hypoxia and neuropsychiatric symptoms, little research has been done to evaluate predictive risk factors.
Objective: The objective of this pilot study is to assess the prevalence and risk factors for aMCI.
Methods: This cross-sectional study was performed using data from patients screened for Memories 2, a clinical trial evaluating the effect of CPAP usage in patients ...
Reduced Recovery Times With Total Intravenous Anesthesia In Patients With Obstructive Sleep Apnea, 2021 Thomas Jefferson University
Reduced Recovery Times With Total Intravenous Anesthesia In Patients With Obstructive Sleep Apnea, Leonard Estephan, Matthew Stewart, Maurits Boon, Colin Huntley
Introduction: There are currently no specific anesthetic guidelines for patients with obstructive sleep apnea (OSA) undergoing upper airway surgery. Two consistently utilized anesthetic approaches during such procedures include inhalational gas anesthesia and total intravenous anesthesia (TIVA), however whether either is more efficacious remains undefined. We hypothesize that administration of TIVA will lead to reduced post-operative recovery time in patients with comorbid OSA undergoing upper airway surgery.
Methods: A retrospective chart review was performed for patients with comorbid OSA that underwent surgery (upper airway stimulation, nasal surgery, palate surgery) between January 2019 and December 2019. Included patients received either inhaled anesthesia ...
Effect Of Trazodone On Upper Airway Resistance In Chronic Spinal Cord Injury, 2021 Wayne State University
Effect Of Trazodone On Upper Airway Resistance In Chronic Spinal Cord Injury, Geoffrey M. Ginter, Sean Carroll, Abdulghani Sankari, Safwan Badr
Medical Student Research Symposium
Spinal cord injury (SCI) is a known risk factor for sleep-disordered breathing. While device-based therapies such as CPAP are beneficial in these individuals, adherence to these treatments is often low; consequently, pharmacotherapies for sleep-disordered breathing in patients with SCI are in high demand. Trazodone is an atypical antidepressant with a complex mechanism of action, including alpha adrenergic agonist activity and inhibition of serotonin reuptake. Serotonin (5-HT) is a known modulator of respiratory circuitry, which has been shown to influence the ventilatory drive. Trazodone is commonly prescribed as a sleep aid, but its impact on breathing during sleep is still ...
Visit-To-Visit Blood Pressure Variability And Sleep Architecture, 2021 University of Virginia
Visit-To-Visit Blood Pressure Variability And Sleep Architecture, Xiaoyue Liu, Jeongok Logan, Younghoon Kwon, Jennifer M. Lobo, Hyojung Kang, Min-Woong Sohn
Health Management and Policy Faculty Publications
Visit‐to‐visit blood pressure (BP) variability (BPV) is an independent risk factor of cardiovascular disease (CVD). Sleep architecture characterizes the distribution of different stages of sleep and may be important in CVD development. We examined the association between visit‐to‐visit BPV and sleep architecture using in‐lab polysomnographic data from 3,565 patients referred to an academic sleep center. BPV was calculated using the intra‐individual coefficient of variation of BP measures collected 12 months before the sleep study. We conducted multiple linear regression analyses to assess the association of systolic and diastolic BPV with sleep architecture—rapid ...
The State Of Sleep: What Keeps Vermont Up At Night?, 2021 University of Vermont Larner College of Medicine
The State Of Sleep: What Keeps Vermont Up At Night?, Magalie Carey
Family Medicine Clerkship Student Projects
No abstract provided.
Sleep Characteristics And Mood Of Professional Esports Athletes: A Multi-National Study, 2021 Edith Cowan University
Sleep Characteristics And Mood Of Professional Esports Athletes: A Multi-National Study, Sangha Lee, Daniel Bonnar, Brandy Roane, Michael Gradisar, Ian C. Dunican, Michele Lastella, Gemma Maisey, Sooyeon Suh
ECU Publications Post 2013
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. Esports is becoming increasingly professionalized, yet research on performance management is remarkably lacking. The present study aimed to investigate the sleep and mood of professional esports athletes. Participants were 17 professional esports athletes from South Korea (N = 8), Australia (N = 4), and the United States (N = 5) who played first person shooter games (mean age 20 ± 3.5 years, 100% male). All participants wore a wrist-activity monitor for 7–14 days and completed subjective sleep and mood questionnaires. Participants had a median total sleep time of 6.8 h and a sleep ...
The Use Of Continuous Positive Airway Pressure In Patients With Obstructive Sleep Apnea To Decrease The Risk And Progression Of Cardiovascular Disease, Haley Duncan
Introduction: Cardiovascular disease is one of the most prevalent illnesses worldwide and the leading cause of death in the United States. Obstructive sleep apnea (OSA) has been found to be a risk factor correlated to cardiovascular disease and events. Treatment for OSA includes the use of continuous positive airway pressure (CPAP), but patients are often non-compliant due to discomfort. Therefore, the following clinical question arises: [P] In an adult patient (35-75 years old) diagnosed with OSA, [I] does the use of CPAP [C: compared to patients with OSA who do not use CPAP] [O]decrease the risk and/or progression ...
The Sleep Of Shift Workers In A Remote Mining Operation: Methodology For A Randomized Control Trial To Determine Evidence-Based Interventions, Gemma Maisey, Marcus Cattani, Amanda Devine, Johnny Lo, Ian C. Dunican
ECU Publications Post 2013
© Copyright © 2021 Maisey, Cattani, Devine, Lo and Dunican. Shiftwork may adversely impact an individual’s sleep-wake patterns and result in sleep loss ( < 6 h. following night shift), due to the circadian misalignment and the design of rosters and shifts. Within a mining operation, this sleep loss may have significant consequences due to fatigue, including an increased risk of accidents and chronic health conditions. This study aims to (i) determine the efficacy of an intervention that comprises a sleep education program and biofeedback through a smartphone app on sleep quality, quantity, and alertness (ii) determine the prevalence of risk for a potential sleep disorder, and (iii) quantify and describe the sleep habits and behaviors of shift workers in a remote mining operation. This study consists of a randomized controlled trial whereby eighty-eight shift workers within a remote mining operation are randomized to a control group or one of three different treatment groups that are: (i) a sleep education program, (ii) biofeedback on sleep through a smartphone app, or (iii) a sleep education program and biofeedback on sleep through a smartphone app. This study utilizes wrist-activity monitors, biomathematical modeling, and a survey instrument to obtain data on sleep quantity, quality, and alertness. A variety of statistical methods will determine the prevalence of risk for a potential sleep disorder and associations with body mass index, alcohol, and caffeine consumption. A generalized linear mixed model will examine the dependent sleep variables assessed at baseline and post-intervention for the control group and intervention groups, as well as within and between groups to determine changes. The findings from this study will contribute to the current understanding of sleep and alertness behaviors, and sleep problems and disorders amongst shift workers. Importantly, the results may inform fatigue policy and practice on interventions to manage fatigue risk within the mining industry. This study protocol may have a broader application in other shiftwork industries, including oil and gas, aviation, rail, and healthcare.
The Physiological Interaction Of Sleep Deprivation And Zoledronate On Distal Femur Trabecular Thickness Of Ovariectomized Rats, Erin Nolte, Frank Frisch, Oliver Lopez
Health Sciences and Kinesiology Faculty Articles
Osteoporosis, a disease resulting in an increased risk of fracture due to compromised bone, affects 1 in 3 postmenopausal women. Discontinuities in the microarchitecture of bone, such as trabeculae, are seen in postmenopausal osteoporosis. This study aimed to evaluate how sleep deprivation affects the distal femur trabecular thickness of estrogen-deficient rats treated with Zoledronate. 29 ovariectomized Wistar female rats were separated into 4 groups. The control group (C) was housed in standard housing with a 12-hour light/dark cycle and was given an intravenous injection of 0.45 mL of 0.9% saline. The Zoledronate group (Z) were also housed ...
A Study Of The Relationship Between Uric Acid And Substantia Nigra Brain Connectivity In Patients With Rem Sleep Behavior Disorder And Parkinson’S Disease, Timothy M. Ellmore, Jessika Suescun, Richard J. Castriotta, Mya C. Schiess
Publications and Research
Low levels of the natural antioxidant uric acid (UA) and the presence of REM sleep behavior disorder (RBD) are both associated with an increased likelihood of developing Parkinson’s disease (PD). RBD and PD are also accompanied by basal ganglia dysfunction including decreased nigrostriatal and nigrocortical resting state functional connectivity. Despite these independent findings, the relationship between UA and substantia nigra (SN) functional connectivity remains unknown. In the present study, voxelwise analysis of covariance was used in a cross-sectional design to explore the relationship between UA and whole-brain SN functional connectivity using the eyes-open resting state fMRI method in controls ...
Rem Rebound Effect, 2020 University of Massachusetts Medical School
Rem Rebound Effect, Joshua Feriante, Shantanu Singh
Open Access Publications by UMMS Authors
Sleep is a state consisting of several different stages of reversible disconnection from the environment with accompanying reduced consciousness, atonia, and metabolic changes. These stages are primarily divided into rapid-eye-movement (REM) sleep, which is characterized by classic ocular saccadic movement and fast-wave EEG patterns reminiscent of wakefulness, and non-rapid-eye movement (NREM) which can be subdivided further into three stages each distinguished by distinct EEG wave patterns. Normally an individual will progress through a predictable cycle of stages beginning with wakefulness, then through each stage of NREM sleep before quickly reversing through the stages to enter REM sleep.
The maintenance of ...
Automatic Recognition, Segmentation, And Sex Assignment Of Nocturnal Asthmatic Coughs And Cough Epochs In Smartphone Audio Recordings: Observational Field Study, Filipe Barata, Peter Tinschert, Frank Rassouli, Claudia Steurer-Stey, Elgar Fleisch, Milo Puhan, Martin Brutsche, David Kotz, Tobias Kowatsch
Background: Asthma is one of the most prevalent chronic respiratory diseases. Despite increased investment in treatment, little progress has been made in the early recognition and treatment of asthma exacerbations over the last decade. Nocturnal cough monitoring may provide an opportunity to identify patients at risk for imminent exacerbations. Recently developed approaches enable smartphone-based cough monitoring. These approaches, however, have not undergone longitudinal overnight testing nor have they been specifically evaluated in the context of asthma. Also, the problem of distinguishing partner coughs from patient coughs when two or more people are sleeping in the same room using contact-free audio ...
Sleep Patterns And Problems Among Children With 22q11 Deletion Syndrome., 2020 Children's Mercy Hospital
Sleep Patterns And Problems Among Children With 22q11 Deletion Syndrome., Jill M. Arganbright, Meghan Tracy, Susan Starling Hughes, David G. Ingram Md
Manuscripts, Articles, Book Chapters and Other Papers
BACKGROUND: To delineate sleep habits and problems in children with 22q11.2 deletion syndrome (22q11DS).
METHODS: Thirty children, age 1-15 (mean 6.8) years, participated in the study, which was an internet-based anonymous survey of parents of children with 22q11DS administered via the 22q11.2 Foundation. The main outcome was the Childhood Sleep Habits Questionnaire (CSHQ).
RESULTS: Scores on the CSHQ demonstrated clinically significant sleep problems in 29 of the 30 children. When compared with previously reported normative values for typically developing children of the same age, children with 22q11DS had significantly greater sleep problems. Only 30% of children had ...
Disposable Equipment For Efficient Home Sleep Apnea Testing And Minimizing Human Handling At The Sleep Laboratory, 2020 Thomas Jefferson University
Disposable Equipment For Efficient Home Sleep Apnea Testing And Minimizing Human Handling At The Sleep Laboratory, Abigail Quintos, Robert Tavella, Karl Doghramji
House Staff Quality Improvement and Patient Safety Conference (2020-)
As part of the disease mitigation strategy at the time of the pandemic, the Jefferson sleep laboratory has completely shifted towards utilization of the third-party vendor for HSATs. The vendor specializes in handling, shipping and disinfecting the HSAT equipment. They send the data electronically to the Jefferson sleep laboratory for interpretation.
We propose a single-use, fully disposable HSAT kit (WatchPAT One) to further minimize potential virus exposures and spread. The single-use design allows no return shipment, no charging or downloading, no cleaning and no infection transmission risk.
Since the equipment utilizes a different mechanism - peripheral arterial tone (PAT) signal instead ...
Urine Drug Screening At The Sleep Disorder Center, 2020 Thomas Jefferson University
Urine Drug Screening At The Sleep Disorder Center, Rohin Saroya, Md, Karl Doghramji, Md
House Staff Quality Improvement and Patient Safety Conference (2020-)
- Introduce UDS for all patients undergoing MSLT or MWT
- Eliminate false positive and negative results
- Optimize management of disorder
- To have 100% of patients undergoing an MSLT or MWT to have a UDS