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Association Of Dtnbp1 With Schizophrenia: Findings From Two Independent Samples Of Han Chinese Population, Yongfeng Yang, Xiaoduo Fan, Ge Yang 2020 Xinxiang Medical University

Association Of Dtnbp1 With Schizophrenia: Findings From Two Independent Samples Of Han Chinese Population, Yongfeng Yang, Xiaoduo Fan, Ge Yang

Psychiatry Publications

Objectives: Schizophrenia (SZ) is a complex psychiatric disorder that has a strong genetic basis. Dystrobrevin-binding protein 1 (DTNBP1) is one of the genes thought to be pivotal in regulating the glutamatergic system. Studies have suggested that variations in DTNBP1 confer susceptibility to SZ and clinical symptoms. Here, we performed a two-stage independent verification study to identify polymorphisms of the DTNBP1 gene that might be associated with SZ in the Han Chinese population.

Methods: In stage 1, 14 single nucleotide polymorphisms (SNPs) were genotyped in 528 paranoid SZ patients and 528 healthy controls (HCs) using the Illumina GoldenGate assays on a ...


Combinatorial Pharmacogenomic Algorithm Is Predictive Of Citalopram And Escitalopram Metabolism In Patients With Major Depressive Disorder, Richard C. Shelton, Anthony J. Rothschild 2020 University of Alabama, Birmingham

Combinatorial Pharmacogenomic Algorithm Is Predictive Of Citalopram And Escitalopram Metabolism In Patients With Major Depressive Disorder, Richard C. Shelton, Anthony J. Rothschild

Psychiatry Publications

Pharmacogenomic tests used to guide clinical treatment for major depressive disorder (MDD) must be thoroughly validated. One important assessment of validity is the ability to predict medication blood levels, which reflect altered metabolism. Historically, the metabolic impact of individual genes has been evaluated; however, we now know that multiple genes are often involved in medication metabolism. Here, we evaluated the ability of individual pharmacokinetic genes (CYP2C19, CYP2D6, CYP3A4) and a combinatorial pharmacogenomic test (GeneSight Psychotropic(R); weighted assessment of all three genes) to predict citalopram/escitalopram blood levels in patients with MDD. Patients from the Genomics Used to Improve DEpression ...


New Onset Psychosis Secondary To Neurosyphilis, Samantha Linda Jane Vu, Lauren Angela DeMarco, Francis Butler, Nihal Shah 2020 HCA Healthcare

New Onset Psychosis Secondary To Neurosyphilis, Samantha Linda Jane Vu, Lauren Angela Demarco, Francis Butler, Nihal Shah

West Florida Division Virtual Research Day

Syphilis is a highly contagious sexually transmitted infection (STI) caused by the spirochetal bacterium Treponema pallidum. Transmission occurs through direct contact of painless ulcerative lesions, chancres, located on the genitalia (penis, labia) and oral mucosa. Neurosyphilis is any involvement of the central nervous systems (brain, meninges, or spinal cord) by the bacterium.


An Atypical Presentation Of Neuroleptic Malignant Syndrome, Rudy Forte, Shiwani Kamath, Debra Angelo, Johnathan Frunzi 2020 HCA Healthcare

An Atypical Presentation Of Neuroleptic Malignant Syndrome, Rudy Forte, Shiwani Kamath, Debra Angelo, Johnathan Frunzi

West Florida Division Virtual Research Day

Neuroleptic Malignant Syndrome (NMS) is a rare, but potentially life threatening condition associated with dopamine blockade, particularly first-generation antipsychotics. The complex pathophysiology of NMS remains somewhat unclear and debatable as the symptoms are not fully explained by dopamine blockade alone.1 D2 dopamine receptor antagonism remains responsible for most cases of NMS, however a few cases have been reported in which little to no D2 blockade activity was present.1

This poster is about an atypical presentation of NMS.


New Horizons: Covid-19 And The Burden Of Neuropsychiatric Illness In Pakistan, Ali M. Hashmi, Haider Ali Saleem 2020 King Edward Medical University/Mayo Hospital, Lahore, Pakistan

New Horizons: Covid-19 And The Burden Of Neuropsychiatric Illness In Pakistan, Ali M. Hashmi, Haider Ali Saleem

Medical College Documents

This manuscript reviews the current state of knowledge about the burden of mental illness and assesses the impact of COVID-19 illness on mental health in Pakistan. For this we analyzed secondary data obtained from the Institute of Health Metrics and Evaluation. The Global Burden of Disease (GBD) study draws from a wide range of data sources to quantify global and regional effects of a disease. We also did a literature search on the effects of COVID-19 illness on mental health and the psychosocial effects of COVID-19 and other Corona virus related illnesses such as SARS-CoV and MERS-CoV. Data from the ...


Acute Disseminated Encephalomyelitis, Ashan Hatharasinghe, Hossein Akhondi, Don Pepito 2020 Sunrise Health GME Consortium

Acute Disseminated Encephalomyelitis, Ashan Hatharasinghe, Hossein Akhondi, Don Pepito

HCA Healthcare Journal of Medicine

Introduction: Acute Disseminated Encephalomyelitis (ADEM) is a rare autoimmune demyelinating disorder of the central nervous system. Clinical manifestations include encephalopathy, motor deficits, ataxia, and meningeal signs. In most cases, ADEM is preceded by either vaccination or viral illness. Here, we present a case with neither of the two predisposing elements.

Discussion: A 28-year-old Hispanic female presenting with substance use and suicidal ideation was placed on an involuntary psychiatric hold, started on olanzapine and scheduled for a psychiatric facility transfer. The following day, she was noted to have neurological deficits when ambulating. Computed tomography of the brain showed a right frontal ...


Reasons For Facebook Usage: Data From 46 Countries, Marta Kowal, Piotr Sorokowski, Agnieszka Sorokowska, Małgorzata Dobrowolska, Katarzyna Pisanski, Anna Oleszkiewicz, Toivo Aavik, Grace Akello, Charlotte Alm, Rizwana Shaikh 2020 University of Wrocław, Wrocław, Poland

Reasons For Facebook Usage: Data From 46 Countries, Marta Kowal, Piotr Sorokowski, Agnieszka Sorokowska, Małgorzata Dobrowolska, Katarzyna Pisanski, Anna Oleszkiewicz, Toivo Aavik, Grace Akello, Charlotte Alm, Rizwana Shaikh

Department of Paediatrics and Child Health

No abstract provided.


A Cognitive Remediation Training For Young Adults With Psychotic Disorders To Support Their Participation In Education - Study Protocol For A Pilot Randomized Controlled Trial, Lana K. M. Otto, Jacomijn Hofstra, Michelle G. Mullen, Derek Malenczak, Nynke Boonstra, Lisette van der Meer, Wim Veling, Cees Boerhout, Gerard D. van Rijsbergen, Jos de Vries, Boudien van der Pol, Gerdina H. M. Pijnenborg, Lies Korevaar 2020 Hanze University of Applied Sciences

A Cognitive Remediation Training For Young Adults With Psychotic Disorders To Support Their Participation In Education - Study Protocol For A Pilot Randomized Controlled Trial, Lana K. M. Otto, Jacomijn Hofstra, Michelle G. Mullen, Derek Malenczak, Nynke Boonstra, Lisette Van Der Meer, Wim Veling, Cees Boerhout, Gerard D. Van Rijsbergen, Jos De Vries, Boudien Van Der Pol, Gerdina H. M. Pijnenborg, Lies Korevaar

Open Access Publications by UMMS Authors

Background: Most severe mental disorders have their onset between the age of 17 and 27, a time when many young adults begin participating in secondary or post-secondary education. The cognitive deficits typically associated with psychiatric disorders, especially psychotic disorders, increase the risk of leaving school early, which can lead to a reduction in employment opportunities later on in life and, in turn, a poorer long-term prognosis. Therefore, specific interventions aiming to improve these cognitive functions are needed. Cognitive remediation (CR) aims to improve cognitive functioning and may increase real-world functioning in educational performance. This study aims to examine the feasibility ...


Valbenazine Has A Small But Meaningful Benefit For Tardive Dyskinesia, Joseph Friedli, Ryan Quick, Reem Sobh, Samantha Cowing 2020 Wayne State University School of Medicine

Valbenazine Has A Small But Meaningful Benefit For Tardive Dyskinesia, Joseph Friedli, Ryan Quick, Reem Sobh, Samantha Cowing

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of

Hauser RA, Factor SA, Marder SR, et al. KINECT 3: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Trial of Valbenazine for Tardive Dyskinesia. Am J Psychiatry. 2017;174(5):476-484. https://doi.org/10.1176/appi.ajp.2017.16091037

and

Factor SA, Remington G, Comella CL, et al. The Effects of Valbenazine in Participants with Tardive Dyskinesia: Results of the 1-Year KINECT 3 Extension Study. J Clin Psychiatry. 2017;78(9):1344-1350. https://doi.org/10.4088/JCP.17m11777

exploring the efficacy of a newer therapy for tardive dyskinesia, and describing recommendations for a ...


Consciousness Level Determination Of Red Meat Consumption Of Pregnant Women, Giresun/Turkey Province, Duygu Balpetek Külcü, Özge Cağcağ Yolcu 2020 DEPARTMENT OF FOOD ENGINEERING, GIRESUN UNIVERSITY, 28200, GIRESUN, TURKEY, DUYGU.BALPETEK@GIRESUN.EDU.TR

Consciousness Level Determination Of Red Meat Consumption Of Pregnant Women, Giresun/Turkey Province, Duygu Balpetek Külcü, Özge Cağcağ Yolcu

Journal of Mind and Medical Sciences

In this study, meat consumption and the nutritional status of pregnant women living in Giresun province of Turkey were investigated. The study was carried out at Giresun University, the Maternity and Pediatrics Training and Research Hospital between February-March 2019. The study group consisted of 218 pregnant women aged 18 to 49 years, who benefited from polyclinic services and agreed to participate in the survey. A questionnaire consisting of 12 questions was used, and the findings were evaluated using SPSS to generate descriptive statistics and t-tests or ANOVAs. The majority of participants stated that red meat is beneficial during pregnancy (71 ...


Impact Of Rational And Experiential Thinking Styles On Interpersonal Conflict Resolution Among Young Adults, Ayesha Rafique, Hania Habib, Fariha Abdul Rehman, Shabnam Arshi 2020 INSTITUTE OF PROFESSIONAL PSYCHOLOGY, BAHRIA UNIVERSITY- KARACHI CAMPUS, KARACHI, PAKISTAN

Impact Of Rational And Experiential Thinking Styles On Interpersonal Conflict Resolution Among Young Adults, Ayesha Rafique, Hania Habib, Fariha Abdul Rehman, Shabnam Arshi

Journal of Mind and Medical Sciences

This research aimed to find the relationship between thinking styles (rational or experiential) and interpersonal conflict resolution (ICR) in young adults. A sample of 99 females and 103 males, age range 18 to 40 years, was selected via convenient and snow-ball sampling. Thinking styles were assessed using Rational-Experiential Inventory-40, and ICR was measured using Conflict Resolution Questionnaire. Regression analysis was used to predict ICR based on thinking style covariates and several relevant demographic covariates, including gender and family birth order. Rational thinking style (RTS) was most prevalent among young adults and was the strongest predictor of ICR. In addition, gender ...


Compassion And Suppression In Caregivers: Twin Masks Of Tragedy And Joy Of Caring, Emanuele Maria Merlo, Sean M. McNabney, Fabio Frisone, Federica Sicari, Mihai Paunica, Catalina Motofei, Salvatore Settineri 2020 DEPARTMENT OF COGNITIVE SCIENCES, PSYCHOLOGY, EDUCATIONAL AND CULTURAL STUDIES (COSPECS), UNIVERSITY OF MESSINA, ITALY

Compassion And Suppression In Caregivers: Twin Masks Of Tragedy And Joy Of Caring, Emanuele Maria Merlo, Sean M. Mcnabney, Fabio Frisone, Federica Sicari, Mihai Paunica, Catalina Motofei, Salvatore Settineri

Journal of Mind and Medical Sciences

Background: Compassionate caregiving is a critical skill for workers among the helping professions, but the degree of empathy required by caregivers can place high demands on their mental and emotional resources. While many professionals employ successful coping strategies to mitigate these stressors, others experience compassion fatigue or burnout from emotional exhaustion. The objective of this research was to evaluate the relationships between caregivers’ demographic/career variables, compassion satisfaction, compassion fatigue, and psychodynamic defense mechanisms such as suppression, repressive function, regression in the service of the Ego, and rationalization. Methods: Participants were 250 caregivers with 178 (71,2%) women and 72 ...


Underactive Bladder - An Underestimated Entity, Spinu Arsenie Dan, Ovidiu Gabriel Bratu, Dragos Radu Marcu, Adina Elena Stanciu, Florentina Gherghiceanu, Florentina Ionita-Radu, Simona Bungau, Ana Maria Alexandra Stanescu, Dan Mischianu 2020 CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY, BUCHAREST, ROMANIA

Underactive Bladder - An Underestimated Entity, Spinu Arsenie Dan, Ovidiu Gabriel Bratu, Dragos Radu Marcu, Adina Elena Stanciu, Florentina Gherghiceanu, Florentina Ionita-Radu, Simona Bungau, Ana Maria Alexandra Stanescu, Dan Mischianu

Journal of Mind and Medical Sciences

Introduction. The concept of underactive bladder is relatively new. Currently there is no generally accepted definition of this pathology. Diagnosis depends on urodynamic findings, and symptoms are usually rare and intricated with the symptoms of other urinary pathology.

Matherials and methods. This review examines the current literature on underactive bladder regarding pathology, definition, diagnosis, current guidelines, and any further potential medical developments.

Conclusions. Underactive bladder is a poorly understood pathologic condition. Only since 2002 has there been any consensus regarding the definition. The diagnosis relies only on urodynamics; clinical diagnosis is a challenge even for a consultant; and treatment does ...


The Role Of Biotransformation Processes In Mediating Interactions Between Psychotropic Drugs And Natural Products, Nicolae Bacinschi, Ina Pogonea, Lilia Podgurschi, Maria Mihalachi-Anghel, Emil Ștefănescu, Bogdan Socea, Marin Chianu 2020 NICOLAE TESTEMITANU STATE UNIVERSITY OF MEDICINE AND PHARMACY, FACULTY OF MEDICINE, DEPARTMENT OF PHARMACOLOGY AND CLINICAL PHARMACOLOGY, CHIȘINĂU, REPUBLIC OF MOLDOVA.

The Role Of Biotransformation Processes In Mediating Interactions Between Psychotropic Drugs And Natural Products, Nicolae Bacinschi, Ina Pogonea, Lilia Podgurschi, Maria Mihalachi-Anghel, Emil Ștefănescu, Bogdan Socea, Marin Chianu

Journal of Mind and Medical Sciences

Many patients are not aware that natural products such as fruit juices or plant infusions can cause significant interactions with several drugs, some of which can be dangerous, especially when the medical treatment is for neurological or psychiatric disorders. Among the most predisposed for interacting with drugs are citric juices, particularly grapefruit and plant infusions, especially St John`s wort (Hypericum perforatum). Understanding the mechanism and the frequency of this type of interaction helps to avoid it. The goal of this research was to identify and summarize the most relevant reports on interactions between psychotropic drugs and natural beverages, in ...


Assessing Physical Activity In People With Mental Illness: 23-Country Reliability And Validity Of The Simple Physical Activity Questionnaire (Simpaq), S Rosenbaum, R Morell, A Abdel-Baki, M Ahmadpanah, T V. Anilkumar, L Baie, A Bauman, S Bender, Zahra Hoodbhoy, Romaina Iqbal, Ayesha Mian 2020 UNSW Sydney, Sydney, Australia

Assessing Physical Activity In People With Mental Illness: 23-Country Reliability And Validity Of The Simple Physical Activity Questionnaire (Simpaq), S Rosenbaum, R Morell, A Abdel-Baki, M Ahmadpanah, T V. Anilkumar, L Baie, A Bauman, S Bender, Zahra Hoodbhoy, Romaina Iqbal, Ayesha Mian

Department of Paediatrics and Child Health

Background: Physical inactivity is a key contributor to the global burden of disease and disproportionately impacts the wellbeing of people experiencing mental illness. Increases in physical activity are associated with improvements in symptoms of mental illness and reduction in cardiometabolic risk. Reliable and valid clinical tools that assess physical activity would improve evaluation of intervention studies that aim to increase physical activity and reduce sedentary behaviour in people living with mental illness.
Methods: The five-item Simple Physical Activity Questionnaire (SIMPAQ) was developed by a multidisciplinary, international working group as a clinical tool to assess physical activity and sedentary behaviour in ...


Development Of An Early-Warning System For High-Risk Patients For Suicide Attempt Using Deep Learning And Electronic Health Records, Le Zheng, Alex N. Sabo, Liliana Markovic, Xuefeng B. Ling 2020 Stanford University

Development Of An Early-Warning System For High-Risk Patients For Suicide Attempt Using Deep Learning And Electronic Health Records, Le Zheng, Alex N. Sabo, Liliana Markovic, Xuefeng B. Ling

Open Access Publications by UMMS Authors

Suicide is the tenth leading cause of death in the United States (US). An early-warning system (EWS) for suicide attempt could prove valuable for identifying those at risk of suicide attempts, and analyzing the contribution of repeated attempts to the risk of eventual death by suicide. In this study we sought to develop an EWS for high-risk suicide attempt patients through the development of a population-based risk stratification surveillance system. Advanced machine-learning algorithms and deep neural networks were utilized to build models with the data from electronic health records (EHRs). A final risk score was calculated for each individual and ...


Effects Of Oral, Smoked, And Vaporized Cannabis On Endocrine Pathways Related To Appetite And Metabolism: A Randomized, Double-Blind, Placebo-Controlled, Human Laboratory Study., Mehdi Farokhnia, Gray R McDiarmid, Matthew N Newmeyer, Vikas Munjal, Osama A Abulseoud, Marilyn A Huestis, Lorenzo Leggio 2020 National Institutes of Health, Johns Hopkins University

Effects Of Oral, Smoked, And Vaporized Cannabis On Endocrine Pathways Related To Appetite And Metabolism: A Randomized, Double-Blind, Placebo-Controlled, Human Laboratory Study., Mehdi Farokhnia, Gray R Mcdiarmid, Matthew N Newmeyer, Vikas Munjal, Osama A Abulseoud, Marilyn A Huestis, Lorenzo Leggio

Institute of Emerging Health Professions Faculty Papers

As perspectives on cannabis continue to shift, understanding the physiological and behavioral effects of cannabis use is of paramount importance. Previous data suggest that cannabis use influences food intake, appetite, and metabolism, yet human research in this regard remains scant. The present study investigated the effects of cannabis administration, via different routes, on peripheral concentrations of appetitive and metabolic hormones in a sample of cannabis users. This was a randomized, crossover, double-blind, placebo-controlled study. Twenty participants underwent four experimental sessions during which oral cannabis, smoked cannabis, vaporized cannabis, or placebo was administered. Active compounds contained 6.9 ± 0.95% (~50 ...


Hyperammonemic Encephalopathy With Triphasic Waves: A Case, Brian Birdsong MD, Brielle Marks MD, Rishim Jayswal MD, Adeel Rahman 2020 HCA Healthcare

Hyperammonemic Encephalopathy With Triphasic Waves: A Case, Brian Birdsong Md, Brielle Marks Md, Rishim Jayswal Md, Adeel Rahman

Psychiatry

No abstract provided.


Famille+: A Multifamily Group Program For Families With Parental Depression, Genevieve Piche, Aude Villatte, Rima Habib, Kelly Vetri, William Beardslee 2020 Universite du Quebec en Outaouais

Famille+: A Multifamily Group Program For Families With Parental Depression, Genevieve Piche, Aude Villatte, Rima Habib, Kelly Vetri, William Beardslee

Journal of Parent and Family Mental Health

Children living with a parent with a depressive disorder are at higher risk for low adaptive functioning, in terms of social, academic, emotional, and mental health problems (Reupert, Maybery & Kowalenko, 2012).This brief describes FAMILLE+, a multifamily group program for parents with major depressive disorder and their 7 to 11 years old children. Its purpose is to prevent the development of mental health problems in children and to promote family resilience and was specifically adapted to fit the children's developmental (cognitive, attentional and socio-emotional) abilities.


Psychiatric Illness And Regression In Individuals With Phelan-Mcdermid Syndrome, Teresa M. Kohlenberg, M. Pilar Trelles, Brittany McLarney, Catalina Betancur, Audrey Thurm, Alexander Kolevzon 2020 University of Massachusetts Medical School

Psychiatric Illness And Regression In Individuals With Phelan-Mcdermid Syndrome, Teresa M. Kohlenberg, M. Pilar Trelles, Brittany Mclarney, Catalina Betancur, Audrey Thurm, Alexander Kolevzon

Open Access Publications by UMMS Authors

BACKGROUND: Phelan-McDermid syndrome (PMS) is a genetic condition characterized by intellectual disability, speech and language deficits, hypotonia, autism spectrum disorder, and epilepsy. PMS is caused by 22q13.33 deletions or mutations affecting SHANK3, which codes for a critical scaffolding protein in excitatory synapses. SHANK3 variants are also known to be associated with an increased risk for regression, as well as for psychiatric disorders, including bipolar disorder and catatonia. This study aimed to further describe these phenomena in PMS and to explore any relationship between psychiatric illness and regression after early childhood.

METHODS: Thirty-eight people with PMS were recruited to this ...


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