Clinical And Functional Outcomes After 2 Years In The Early Detection And Intervention For The Prevention Of Psychosis Multisite Effectiveness Trial,
2015
Hofstra Northwell School of Medicine
Clinical And Functional Outcomes After 2 Years In The Early Detection And Intervention For The Prevention Of Psychosis Multisite Effectiveness Trial, W. R. Mcfarlane, B. Levin, L. Travis, F. L. Lucas, S. Lynch, M. Verdi, Barbara Cornblatt, S. F. Taylor, A. M. Auther, E. Spring, +11 Additional Authors
Journal Articles
OBJECTIVE: To test effectiveness of the Early Detection, Intervention, and Prevention of Psychosis Program in preventing the onset of severe psychosis and improving functioning in a national sample of at-risk youth. METHODS: In a risk-based allocation study design, 337 youth (age 12-25) at risk of psychosis were assigned to treatment groups based on severity of positive symptoms. Those at clinically higher risk (CHR) or having an early first episode of psychosis (EFEP) were assigned to receive Family-aided Assertive Community Treatment (FACT); those at clinically lower risk (CLR) were assigned to receive community care. Between-groups differences on outcome variables were adjusted …
Insistence On Sameness Relates To Increased Covariance Of Gray Matter Structure In Autism Spectrum Disorder.,
2015
George Washington University
Insistence On Sameness Relates To Increased Covariance Of Gray Matter Structure In Autism Spectrum Disorder., Ian W Eisenberg, Gregory L Wallace, Lauren Kenworthy, Stephen J Gotts, Alex Martin
Psychiatry and Behavioral Sciences Faculty Publications
BACKGROUND: Autism spectrum disorder (ASD) is characterized by atypical development of cortical and subcortical gray matter volume. Subcortical structural changes have been associated with restricted and repetitive behavior (RRB), a core component of ASD. Behavioral studies have identified insistence on sameness (IS) as a separable RRB dimension prominent in high-functioning ASD, though no simple brain-behavior relationship has emerged. Structural covariance, a measure of morphological coupling among brain regions using magnetic resonance imaging (MRI), has proven an informative measure of anatomical relationships in typical development and neurodevelopmental disorders. In this study, we use this measure to characterize the relationship between brain …
Cannabinoid Cb2 Receptors In A Mouse Model Of A Beta Amyloidosis: Immunohistochemical Analysis And Suitability As A Pet Biomarker Of Neuroinflammation,
2015
Hofstra Northwell School of Medicine
Cannabinoid Cb2 Receptors In A Mouse Model Of A Beta Amyloidosis: Immunohistochemical Analysis And Suitability As A Pet Biomarker Of Neuroinflammation, A. V. Savonenko, T. Melnikova, Y. C. Wang, H. Ravert, Y. J. Gao, J. Koppel, D. Lee, P. Davies, M. G. Pomper, A. G. Horti, +6 Additional Authors
Journal Articles
In Alzheimer's disease (AD), one of the early responses to A beta amyloidosis is recruitment of microglia to areas of new plaque. Microglial receptors such as cannabinoid receptor 2 (CB2) might be a suitable target for development of PET radiotracers that could serve as imaging biomarkers of A beta-induced neuroinflammation. Mouse models of amyloidosis (J20APPswe/ind and APPswe/PS1 Delta E9) were used to investigate the cellular distribution of CB2 receptors. Specificity of CB2 antibody (H60) was confirmed using J20APPswe/ind mice lacking CB2 receptors. APPswe/PS1 Delta E9 mice were used in small animal PET with a CB2-targeting radiotracer, [C-11]A836339. These studies revealed …
Lifetime Prevalence, Age Of Risk, And Genetic Relationships Of Comorbid Psychiatric Disorders In Tourette Syndrome,
2015
Northwell Health
Lifetime Prevalence, Age Of Risk, And Genetic Relationships Of Comorbid Psychiatric Disorders In Tourette Syndrome, M. E. Hirschtritt, P. C. Lee, D. L. Pauls, Y. Dion, M. A. Grados, R. A. King, P. Sandor, W. M. Mcmahon, G. J. Lyon, C. A. Mathews, +4 Additional Authors
Journal Articles
IMPORTANCE: Tourette syndrome (TS) is characterized by high rates of psychiatric comorbidity; however, few studies have fully characterized these comorbidities. Furthermore, most studies have included relatively few participants (
Abnormal Resting State Fmri Activity Predicts Processing Speed Deficits In First-Episode Psychosis,
2015
Hofstra Northwell School of Medicine
Abnormal Resting State Fmri Activity Predicts Processing Speed Deficits In First-Episode Psychosis, M. Argyelan, J. A. Gallego, D. G. Robinson, T. Ikuta, D. Sarpal, M. John, P. B. Kingsley, J. M. Kane, A. K. Malhotra, P. R. Szeszko
Journal Articles
Little is known regarding the neuropsychological significance of resting state functional magnetic resonance imaging (rs-fMRI) activity early in the course of psychosis. Moreover, no studies have used different approaches for analysis of rs-fMRI activity and examined gray matter thickness in the same cohort. In this study, 41 patients experiencing a first-episode of psychosis (including N = 17 who were antipsychotic drug-naive at the time of scanning) and 41 individually age-and sex-matched healthy volunteers completed rs-fMRI and structural MRI exams and neuropsychological assessments. We computed correlation matrices for 266 regions-of-interest across the brain to assess global connectivity. In addition, independent component …
Expanded Genetic Screening Panel For The Ashkenazi Jewish Population,
2015
Northwell Health
Expanded Genetic Screening Panel For The Ashkenazi Jewish Population, B. Baskovich, I. Peter, J. H. Cho, G. Atzmon, L. Clark, J. Yu, T. Lencz, I. Pe'er, H. Ostrer, C. Oddoux, +7 Additional Authors
Journal Articles
PURPOSE: Carrier screening programs that identify the presence of known mutations have been effective for reducing the incidence of autosomal recessive conditions in the Ashkenazi Jewish (AJ) population and other populations. Yet, these programs have not realized their full potential. Furthermore, many known autosomal recessive and dominant conditions are not screened for and the molecular basis of other conditions for which screening might be offered is unknown. METHODS: Through literature review and annotation of full sequenced genomes from healthy individuals, we expanded the list of mutations. Mutations were identified in a sample of 128 fully sequenced AJ genomes that were …
Prenatal Exposure To Maternal Smoking And Symptom Severity Among Offspring With First-Episode Nonaffective Psychosis,
2015
Northwell Health
Prenatal Exposure To Maternal Smoking And Symptom Severity Among Offspring With First-Episode Nonaffective Psychosis, F. Bernardini, C. R. Wan, A. Crisafio, S. H. Massey, M. T. Compton
Journal Articles
No abstract provided.
Role Of Social Media And The Internet In Pathways To Care For Adolescents And Young Adults With Psychotic Disorders And Non-Psychotic Mood Disorders,
2015
Hofstra Northwell School of Medicine
Role Of Social Media And The Internet In Pathways To Care For Adolescents And Young Adults With Psychotic Disorders And Non-Psychotic Mood Disorders, M. L. Birnbaum, A. F. Rizvi, Christoph Correll, J. M. Kane
Journal Articles
AIMS: Although psychosis often occurs during adolescence, there has been little research on how the ubiquitously used Internet and social media could impact pathways to care. We examined how youth with psychotic spectrum disorders (PSD) versus non-psychotic mood disorders (NPMD) use online resources in the early illness stages. METHODS: Social media use and pathways to care data were collected using a semi-structured interview from 80 youth (PSD = 40 and NPMD = 40) aged 12-21 years within 2 years of symptom onset. RESULTS: A total of 97.5% of participants (mean age = 18.3 years) regularly used social media, spending approximately …
Evaluating The Impact Of Cannabis Use On Thalamic Connectivity In Youth At Clinical High Risk Of Psychosis,
2015
Hofstra Northwell School of Medicine
Evaluating The Impact Of Cannabis Use On Thalamic Connectivity In Youth At Clinical High Risk Of Psychosis, L. Buchy, T. D. Cannon, A. Anticevic, K. Lyngberg, K. S. Cadenhead, B. A. Cornblatt, D. O. Perkins, L. J. Seidman, M. T. Tsuang, J. Addington, +5 Additional Authors
Journal Articles
No abstract provided.
Evaluating The Relationship Between Cannabis Use And Iq In Youth And Young Adults At Clinical High Risk Of Psychosis,
2015
Hofstra Northwell School of Medicine
Evaluating The Relationship Between Cannabis Use And Iq In Youth And Young Adults At Clinical High Risk Of Psychosis, L. Buchy, L. J. Seidman, K. S. Cadenhead, T. D. Cannon, B. A. Cornblatt, E. F. Walker, S. W. Woods, C. E. Bearden, D. H. Mathalon, J. Addington, +4 Additional Authors
Journal Articles
Among people with psychosis, those with a history of cannabis use show better cognitive performance than those who are cannabis naive. It is unknown whether this pattern is present in youth at clinical high risk (CHR) of psychosis. We evaluated relationships between IQ and cannabis use while controlling for use of other substances known to impact cognition in 678 CHR and 263 healthy control (HC) participants. IQ was estimated using the Vocabulary and Block Design subtests of the Wechsler Abbreviated Scale of Intelligence. Drug and alcohol use severity and frequency were assessed with the Alcohol and Drug Use Scale, and …
Contributions Of Early Cortical Processing And Reading Ability To Functional Status In Individuals At Clinical High Risk For Psychosis,
2015
Hofstra Northwell School of Medicine
Contributions Of Early Cortical Processing And Reading Ability To Functional Status In Individuals At Clinical High Risk For Psychosis, R. Carrion, B. A. Cornblatt, D. Mclaughlin, J. Chang, A. M. Auther, R. H. Olsen, D. C. Javitt
Journal Articles
Background: There is a growing recognition that individuals at clinical high risk need intervention for functional impairments, along with emerging psychosis, as the majority of clinical high risk (CHR) individuals show persistent deficits in social and role functioning regardless of transition to psychosis. Recent studies have demonstrated reduced reading ability as a potential cause of functional disability in schizophrenia, related to underlying deficits in generation of mismatch negativity (MMN). The present study extends these findings to subjects at CHR. Methods: The sample consisted of 34 CHR individuals and 33 healthy comparison subjects (CNTLs) from the Recognition and Prevention (RAP) Program …
The Impact Of Psychosis On The Course Of Cognition: A Prospective, Nested Case-Control Study In Individuals At Clinical High-Risk For Psychosis,
2015
Hofstra Northwell School of Medicine
The Impact Of Psychosis On The Course Of Cognition: A Prospective, Nested Case-Control Study In Individuals At Clinical High-Risk For Psychosis, R. Carrion, D. Mclaughlin, A. M. Auther, R. Olsen, Christoph Correll, B. A. Cornblatt
Journal Articles
BACKGROUND: Although cognitive deficits in patients with schizophrenia are rooted early in development, the impact of psychosis on the course of cognitive functioning remains unclear. In this study a nested case-control design was used to examine the relationship between emerging psychosis and the course of cognition in individuals ascertained as clinical high-risk (CHR) who developed psychosis during the study (CHR + T). METHOD: Fifteen CHR + T subjects were administered a neurocognitive battery at baseline and post-psychosis onset (8.04 months, s.d. = 10.26). CHR + T subjects were matched on a case-by-case basis on age, gender, and time to retest …
Postnatal Neurodevelopmental Expression And Glutamate-Dependent Regulation Of The Znf804a Rodent Homologue,
2015
Hofstra Northwell School of Medicine
Postnatal Neurodevelopmental Expression And Glutamate-Dependent Regulation Of The Znf804a Rodent Homologue, E. H. Chang, A. Kirtley, T. S. Chandon, P. Borger, S. Husain-Krautter, V. Vingtdeux, A. Malhotra
Journal Articles
The zinc finger protein ZNF804A rs1344706 variant is a replicated genome-wide significant risk variant for schizophrenia and bipolar disorder. While its association with altered brain structure and cognition in patients and healthy risk allele carriers is well documented, the characteristics and function of the gene in the brain remains poorly understood. Here, we used in situ hybridization to determine mRNA expression levels of the ZNF804A rodent homologue, Zfp804a, across multiple postnatal neurodevelopmental time points in the rat brain. We found changes in Zfp804a expression in the rat hippocampus, frontal cortex, and thalamus across postnatal neurodevelopment. Zfp804a mRNA peaked at postnatal …
Responses To Tobacco Smoking-Related Health Messages In Young People With Recent-Onset Schizophrenia,
2015
Hofstra Northwell School of Medicine
Responses To Tobacco Smoking-Related Health Messages In Young People With Recent-Onset Schizophrenia, D. J. Coletti, M. Brunette, M. John, J. M. Kane, A. Malhotra, D. G. Robinson
Journal Articles
Virtually no research has examined the responses of youth with recent-onset psychosis (ROP) to smoking-related health warnings. We examined predictors of response and tested hypotheses that participants with ROP would (a) assess warnings as less effective than a healthy comparison (HC) group, and (b) assess video warnings as more effective than pictures. ROP participants (n = 69) hadtreatment; the HC group (n = 79) had no major mental illness. Participants viewed 10 pictorial warnings, 8 videos depicting similar messages, and were interviewed regarding tobacco use, health literacy, and smoking knowledge. We assessed response at baseline and at 4-week follow-up. ROP …
Personality Domains, Duration Of Untreated Psychosis, Functioning, And Symptom Severity In First-Episode Psychosis,
2015
Hofstra Northwell School of Medicine
Personality Domains, Duration Of Untreated Psychosis, Functioning, And Symptom Severity In First-Episode Psychosis, M. Compton, R. Bakeman, Y. Alolayan, P. M. Balducci, F. Bernardini, B. Broussard, A. Crisafio, S. Cristofaro, S. Johnson, C. R. Wan, +1 Additional Author
Journal Articles
OBJECTIVES: Early-course psychotic disorders have been extensively studied in terms of phenomenology, but little is known about the influence of personality traits on clinical features of first-episode psychosis. The aim of this study was to explore how the "big five" personality domains (neuroticism, extraversion, openness, agreeableness, and conscientiousness) are associated with treatment delay (duration of untreated psychosis, DUP), functioning, and positive and negative symptom severity. METHODS: Data for these analyses were obtained from 104 participants enrolled from psychiatric inpatient units in Atlanta, Georgia, between August 2008 and March 2011. The NEO Five-Factor Inventory (NEO-FFI) was used to assess personality domains, …
Psychosis Prevention: A Modified Clinical High Risk Perspective From The Recognition And Prevention (Rap) Program,
2015
Hofstra Northwell School of Medicine
Psychosis Prevention: A Modified Clinical High Risk Perspective From The Recognition And Prevention (Rap) Program, B. A. Cornblatt, R. Carrion, A. Auther, D. Mclaughlin, R. H. Olsen, M. John, C. U. Correll
Journal Articles
OBJECTIVE: Early intervention and prevention of psychosis remain a major challenge. Prediction would be greatly advanced with improved ability to identify individuals at true risk, which, at present, is moderate at best. The authors tested a modified strategy to improve prediction by selecting a more homogeneous high-risk sample (attenuated positive symptom criteria only, age range of mid-teens to early 20s) than is currently standard, combined with a systematic selection of neurodevelopmental deficits. METHOD: A sample of 101 treatment-seeking adolescents (mean age, 15.9 years) at clinical high risk for psychosis were followed clinically for up to 5 years (mean follow-up time, …
Cardiovascular And Cerebrovascular Risk Factors And Events Associated With Second-Generation Antipsychotic Compared To Antidepressant Use In A Non-Elderly Adult Sample: Results From A Claims-Based Inception Cohort Study,
2015
Hofstra Northwell School of Medicine
Cardiovascular And Cerebrovascular Risk Factors And Events Associated With Second-Generation Antipsychotic Compared To Antidepressant Use In A Non-Elderly Adult Sample: Results From A Claims-Based Inception Cohort Study, C. U. Correll, B. I. Joffe, L. M. Rosen, T. B. Sullivan, R. T. Joffe
Journal Articles
This is a study of the metabolic and distal cardiovascular/cerebrovascular outcomes associated with the use of second-generation antipsychotics (SGAs) compared to antidepressants (ADs) in adults aged 18-65 years, based on data from Thomson Reuters MarketScan (R) Research Databases 2006-2010, a commercial U.S. claims database. Interventions included clinicians' choice treatment with SGAs (allowing any comedications) versus ADs (not allowing SGAs). The primary outcomes of interest were time to inpatient or outpatient claims for the following diagnoses within one year of SGA or AD discontinuation: hypertension, ischemic and hypertensive heart disease, cerebrovascular disease, diabetes mellitus, hyperlipidemia, and obesity. Secondary outcomes included the …
Examining The Psychosis Continuum,
2015
Northwell Health
Examining The Psychosis Continuum, P. Derosse, K. H. Karlsgodt
Journal Articles
The notion that psychosis may exist on a continuum with normal experience has been proposed in multiple forms throughout the history of psychiatry. However, in recent years there has been an exponential increase in efforts aimed at elucidating what has been termed the 'psychosis continuum'. The present review seeks to summarize some of the more basic characteristics of this continuum and to present some of the recent findings that provide support for its validity. While there is still considerable work to be done, the emerging data holds considerable promise for advancing our understanding of both risk and resilience to psychiatric …
Reliability Of An Fmri Paradigm For Emotional Processing In A Multisite Longitudinal Study,
2015
Hofstra Northwell School of Medicine
Reliability Of An Fmri Paradigm For Emotional Processing In A Multisite Longitudinal Study, D. G. Gee, S. C. Mcewen, J. K. Forsyth, K. M. Haut, C. E. Bearden, K. S. Cadenhead, H. Mirzakhanian, B. A. Cornblatt, D. Olvet, T. D. Cannon, +14 Additional Authors
Journal Articles
Multisite neuroimaging studies can facilitate the investigation of brain-related changes in many contexts, including patient groups that are relatively rare in the general population. Though multisite studies have characterized the reliability of brain activation during working memory and motor functional magnetic resonance imaging tasks, emotion processing tasks, pertinent to many clinical populations, remain less explored. A traveling participants study was conducted with eight healthy volunteers scanned twice on consecutive days at each of the eight North American Longitudinal Prodrome Study sites. Tests derived from generalizability theory showed excellent reliability in the amygdala ( Erho2 = 0.82), inferior frontal gyrus (IFG; …
Subcortical Modulation In Auditory Processing And Auditory Hallucinations,
2015
Northwell Health
Subcortical Modulation In Auditory Processing And Auditory Hallucinations, T. Ikuta, P. Derosse, M. Argyelan, K. H. Karlsgodt, P. B. Kingsley, P. R. Szeszko, A. K. Malhotra
Journal Articles
Hearing perception in individuals with auditory hallucinations has not been well studied. Auditory hallucinations have previously been shown to involve primary auditory cortex activation. This activation suggests that auditory hallucinations activate the terminal of the auditory pathway as if auditory signals are submitted from the cochlea, and that a hallucinatory event is therefore perceived as hearing. The primary auditory cortex is stimulated by some unknown source that is outside of the auditory pathway. The current study aimed to assess the outcomes of stimulating the primary auditory cortex through the auditory pathway in individuals who have experienced auditory hallucinations. Sixteen patients …
