Osteopathic Medicine and Osteopathy Commons^™

Does The Osteopathic Pedal Pump Reduce Lower Limb Volume In Healthy Subjects?, Jill S. Adams, Sahil H. Parikh, Brandon J. Goodwin, Donald R. Noll

Rowan-Virtua School of Osteopathic Medicine Departmental Research

CONTEXT: Lymphatic treatments are gentle and passive techniques believed to enhance movement of lymph back into the central circulatory system. Animal studies provide supportive evidence, yet there are few studies in humans.

OBJECTIVES: The aim of this study is to investigate whether the osteopathic pedal pump protocol reduces volume in the lower limbs of healthy subjects.

METHODS: A total of 30 first- and second-year medical students were recruited. Subjects were excluded from participating if they had acute asthma, chronic obstructive pulmonary disease (COPD), congestive heart failure, active infections, fractures of the lower extremities, or metastatic cancer. A within-subjects study design …

The Day The Pride Of The Yankees And The Sultan Of Swat Visited Children's Mercy Hospital, Robyn Oro

Notes from the Archives

No abstract provided.

New England Osteopathic Association: Constitution, New England Osteopathic Association

John McPartland, D.O. Collection

Constitution of the New England Osteopathic Association organized in Boston January 28, 1905.

Vermont State Association Of Osteopathic Physician And Surgeons Inc.: Correspondence Soliciting New D.O.S To Vermont, Vermont State Association Of Osteopathic Physicians And Surgeons Inc.

John McPartland, D.O. Collection

A letter from the Vermont State Association of Osteopathic Physicians and Surgeons, Inc. soliciting D.O.s to move to Vermont.

Nefom: Board Of Trustees: Corporation Members, New England Foundation For Osteopathic Medicine

William Kirmes, D.O. Collection

List of NEFOM corporation members, undated.

New England Osteopathic Assembly: Maxwell To Kirmes, R. E. Maxwell D.O.

William Kirmes, D.O. Collection

A short handwritten personal note from Dr. R.E. Maxwell to Dr. Kirmes arranging their trip to the New England Osteopathic Assembly meeting.

New Hampshire Osteopathic Association: Dr. Kirmes To Potential New Hampshire D.O.S, William Kirmes D.O.

William Kirmes, D.O. Collection

A letter from Dr. Kirmes to potential New Hampshire D.O.s recommending coming to New Hampshire to practice.

Vermont Osteopathic Association: Address Regarding Basic Science Bill, Unknown

John McPartland, D.O. Collection

An address given by a member of the Vermont Osteopathic Association regarding the Vermont State Basic Science Bill.

Utilizing The Zebrafish Species, Danio Rerio, To Assess The Effect Of Acute Treatment With St. John’S Wort Supplements On Anxiety As Measured By The Novel Dive Tank Test, Sebastian Woodson, Lori Mcgrew Dr.

Research Projects

Background: The zebrafish species, Danio rerio, is a widely utilized model organism with well-characterized behaviors including anxiety-like behavior when placed into a novel environment. In addition, the fish can be treated with substances by immersion.

St. John’s Wort has been suggested as a plant-based treatment for depression and anxiety because it contains compounds that inhibit the serotonin transporter (SERT) among other effects. A number of St. John’s Wort supplements are commercially available.

The National Institute of Mental Health (NIMH) estimates that about 19% of US adults suffer an anxiety disorder each year and about 31% will experience an anxiety disorder …

January 2023, New England Osteopathic Heritage Center

New England Osteopathic Heritage Center Newsletter

New England Osteopathic Heritage Center's annual newsletter for January 2023

Nefom: What Is An Osteopathic Physician Anyway?, New England Foundation For Osteopathic Medicine

William Kirmes, D.O. Collection

A pamphlet entitled "What is an Osteopathic Physician Anyway?"

The Efficacy Of Prp Injection Vs Corticosteroid Injection In The Management Of Common Tendinopathies: A Systematic Review, Eric Caloud

Theses and Graduate Projects

Background: Tendinopathy is one of the most prevalent musculoskeletal disorders in active patients, accounting for at least 7% of physician visits in the United States. In recent years, there has been an increasing body of evidence for the use of platelet-rich plasma (PRP) in the management of tendinopathies compared to corticosteroid injections (CSI) for patients refractory to conservative treatment.

Methods: This review was performed in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The SPORTDiscus, PubMed, and Google Scholar databases were searched for randomized controlled studies published between 2010 and 2023. The keywords utilized in the …

2023‐2024 Student Research Fellowship Recipients, University Of New England College Of Osteopathic Medicine

Peter Morgane Research Fellowships

2023-2024 recipients of the University of New England College of Osteopathic Medicine's Peter Morgane Research Fellowship.

Digest Of The Philadelphia College Of Osteopathic Medicine (2023, No. 1), Philadelphia College Of Osteopathic Medicine

PCOM Digest 2020s

The 2023 Vol. 1 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Updates
• Advancing Alumni
• Institutional Heritage: Founders’ Day 2023
• Digest Magazine Anniversary Series: 125 Years Through 125 Stories
• The Longest-Tenured Dean: Kenneth J. Veit, DO ’76, MBA, FACOFP, reflects on his historic distinction
• This Old House: The story of the Tudor Revival-style mansion that was renovated to become an administration building at the heart of the PCOM campus in Philadelphia
• Class Notes

Sexually-Divergent Differentiation And Inflammatory Response To Osteoclasts, Lilijanna L. Cummings

EWU Masters Thesis Collection

No abstract provided.

Effect Of Stretch And Release On Myofascial Stem Cell Function In Vitro: A Putative Model To Understand The Molecular Benefits Of The Myofascial Release (Mfr) Technique, Ben Smith, Shahn Notta, Debasis Mondal

Research Day

Despite the beneficial effects of osteopathic manipulative techniques (OMT), there is a lack of in vitro models to understand the molecular mechanisms associated with these time-tested therapies. The Myofascial Release (MFR) technique is a non-invasive approach that involves passive stretching, hold and release, of the soft tissue to achieve myofascial homeostasis. Tissue-resident mesenchymal stem cells (MSC) can regulate the myofascial microenvironment by altering their secreted factors following stretch and release. Therefore, we initiated studies to develop an in vitro model to investigate the possible effects of stretch and release on MSC function, i.e. proliferation and differentiation capabilities, and changes in …

The Effects Of Sex On Zebrafish Bone Metabolism, Simon Bagatto

Williams Honors College, Honors Research Projects

I investigated the effects of diet and sex on zebrafish bone metabolism. Zebrafish were subjected to either a high-calorie or low-calorie diet over a five-week period. After this diet, zebrafish scales were used to measure alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP) enzyme activity with a fluorescent substrate. The enzyme activities were markers of the osteoblasts (ALP) and the osteoclasts (TRAP). These data were compared among sex and diet of the zebrafish using a repeated measures ANOVA statistical test. I also measured the number of resorption lacunae per scale (another indicator of osteoclast activity). The results showed higher TRAP …

Osteoblast-Specific Overexpression Of Nucleolar Protein No66/Riox1 In Mouse Embryos Leads To Osteoporosis In Adult Mice, Qin Chen, Krishna M Sinha, Benoit De Crombrugghe, Ralf Krahe

Faculty, Staff and Student Publications

In previous study, we showed that nucleolar protein 66 (NO66) is a chromatin modifier and negatively regulates Osterix activity as well as mesenchymal progenitor differentiation. Genetic ablation of the NO66 (RIOX1) gene in cells of the Prx1-expressing mesenchymal lineage leads to acceleration of osteochondrogenic differentiation and a larger skeleton in adult mice, whereas mesenchyme-specific overexpression of NO66 inhibits osteochondrogenesis resulting in dwarfism and osteopenia. However, the impact of NO66 overexpression in cells of the osteoblast lineage in vivo remains largely undefined. Here, we generated osteoblast-specific transgenic mice overexpressing a FLAG-tagged NO66 transgene driven by the …

Using The Articularis Genu To Test Peri-Articular Muscle Health During Knee Osteoarthritis, José A. Cruz Ayala, Mallory Crawford, Mary C. Gatterer, Maria Tovar, Jessica C. Rivera, Vinod Dasa, Luis Marrero

School of Medicine Faculty Publications

Knee osteoarthritis (OA) involves peri-articular sarcopenia. The infrapatellar articularis genu (AG) links to the quadriceps femoris (QF) and can be sampled from discarded tissue during arthroplasty. We predict disuse-mediated changes in AG myofiber type ratio and atrophy similar to reports on the QF during OA. OA AGs (n = 40) were preserved and grouped by poor (≤ 85°; n = 11), fair (90°–110°; n = 19), and good (≥ 115°; n = 10) range of motion (ROM). Immunolabeling of slow and fast myosin heavy chains in AG sections allowed comparing distribution and cross-sectional area (CSA) of type-I (T1) and type-II …

Mice Lacking Wnt9a Or Wnt4 Are Prone To Develop Spontaneous Osteoarthritis With Age And Display Alteration In Either The Trabecular Or Cortical Bone Compartment, Stefan Teufel, Lena Wolff, Ulrich König, Akio Kobayashi, Richard Behringer, Christine Hartmann

Faculty, Staff and Student Publications

Osteoarthritis (OA) is a common degenerative disease of the joint, with a complex multifactorial not yet fully understood etiology. Over the past years, the Wnt signaling pathway has been implicated in osteoarthritis. In a recent genomewide association study (GWAS), the chromosomal location on chromosome 1, linked to the Wnt3a-Wnt9a gene locus, was identified as the most significant locus associated with a thumb osteoarthritis endophenotype. Previously, it was shown that WNT9a is involved in maintaining synovial cell identity in the elbow joint during embryogenesis. Here, we report that the conditional loss of Wnt9a in the Prx1-Cre expressing limb mesenchyme or Prg4-CreER …