Distance Runners In Appalachia: A Survey Of Injuries, Training, And Dietary Habits, Justine Falcone Md, Katherine Langley Md, Brenden Balcik Md, Rosanna Sikora Md, Melinda Sharon Mph, Aaron Monseau Md
Faculty & Staff Scholarship
Objectives: The purpose was to examine characteristics of an Appalachian population of runners. The primary aim was to examine risk factors for running related injury (RRI), including mileage per week, experience, and use of applications/training programs. A second aim was to characterize dietary habits among runners. Methods: This study was conducted in September 2015 in North Central Appalachian West Virginia. The Morgantown Marathon consists of three races offered every September: an 8K, half marathon, and full marathon. Surveys were offered to runners ages 18 and older during packet pick-up. For this survey study, questions consisted of multiple choice and ...
Adipose-Specific Pparα Knockout Mice Have Increased Lipogenesis By Pask–Srebp1 Signaling And A Polarity Shift To Inflammatory Macrophages In White Adipose Tissue, Terry D. Hinds, Jr., Zachary A. Kipp, Mei Xu, Frederique B. Yiannikouris, Andrew J. Morris, Donald F. Stec, Walter Wahli, David E. Stec
Pharmacology and Nutritional Sciences Faculty Publications
The nuclear receptor PPARα is associated with reducing adiposity, especially in the liver, where it transactivates genes for β-oxidation. Contrarily, the function of PPARα in extrahepatic tissues is less known. Therefore, we established the first adipose-specific PPARα knockout (PparaFatKO) mice to determine the signaling position of PPARα in adipose tissue expansion that occurs during the development of obesity. To assess the function of PPARα in adiposity, female and male mice were placed on a high-fat diet (HFD) or normal chow for 30 weeks. Only the male PparaFatKO animals had significantly more adiposity in the inguinal white adipose tissue ...
Nutritional Supplementation To Reduce The Risk Of Malnutrition In The Dsu, 2021 Providence St. Joseph Health
Nutritional Supplementation To Reduce The Risk Of Malnutrition In The Dsu, Rebeca Zamora, Bsn, Rn, Pccn
St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference
No abstract provided.
Intestinal Dysbiosis – A New Treatment Target In The Prevention Of Colorectal Cancer, 2021 EMERGENCY HOSPITAL OF CONSTANTA, DEPARTMENT OF GASTROENTEROLOGY, CONSTANTA, ROMANIA
Intestinal Dysbiosis – A New Treatment Target In The Prevention Of Colorectal Cancer, Florinela-Andrada Dumitru, Sergiu Ioan Micu, Roxana Emanuela Popoiag, Marilena Musat, Andreea Daniela Caloian, Valentin Calu, Vlad Denis Constantin, Daniela Gabriela Balan, Cornelia Nitipir, Florin Enache
Journal of Mind and Medical Sciences
The gastrointestinal microbiome contains at least 100 trillion microorganisms (bacteria, viruses, fungi), whose distribution varies from the mouth to the rectum spatially and temporally throughout one's lifetime. The microbiome benefits from advancing research due to its major role in human health. Studies indicate that its functions are immunity, metabolic processes and mucosal barrier. The disturbances of these functions, dysbiosis, influence physiology, lead to diabetes, inflammatory bowel disease, obesity and colon tumorigenesis. The third most common form of cancer, colorectal cancer, is the result of many factors and genes, and although the link between dysbiosis and this type of cancer ...
The Relationship Between Adiponectin And Dietary Iron In Non-Diabetic Young Women, 2021 Kennesaw State University
The Relationship Between Adiponectin And Dietary Iron In Non-Diabetic Young Women, Calah Coleman
Symposium of Student Scholars
Introduction: Adiponectin is a protein-based hormone that is secreted by adipocytes and assists in several metabolic processes including glucose regulation and fatty acid oxidation. Low adiponectin levels have been linked to metabolic conditions such as increased insulin resistance and obesity. Previous studies have shown that circulating iron has an inverse relationship with adiponectin levels. It is unknown whether dietary iron has the same association with adiponectin levels.
Purpose: The purpose of this study is to examine the relationship between dietary iron intake and adiponectin levels.
Methods: This study examined 42 non-diabetic women (Age: 20.7 ±2.8 years; BMI 27 ...
Elevated Lipid Oxidation Is Associated With Exceeding Gestational Weight Gain Recommendations And Increased Neonatal Anthropometrics: A Cross-Sectional Analysis, Jill M. Maples, Samantha F. Ehrlich, Nikki B. Zite, Kevin J. Pearson, W. Todd Cade, Courtney J. Riedinger, Maire M. Blankenship, Rachel A. Tinius
Pharmacology and Nutritional Sciences Faculty Publications
BACKGROUND: Deviations from gestational weight gain (GWG) recommendations are associated with unfavorable maternal and neonatal outcomes. There is a need to understand how maternal substrate metabolism, independent of weight status, may contribute to GWG and neonatal outcomes. The purpose of this study was to explore the potential link between maternal lipid oxidation rate, GWG, and neonatal anthropometric outcomes.
METHODS: Women (N = 32) with a lean pre-pregnancy BMI were recruited during late pregnancy and substrate metabolism was assessed using indirect calorimetry, before and after consumption of a high-fat meal. GWG was categorized as follows: inadequate, adequate, or excess. Shortly after delivery ...
Gestational Weight Gain In 4 Low- And Middle-Income Countries And Associations With Birth Outcomes: A Secondary Analysis Of The Women First Trial., 2021 Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
Gestational Weight Gain In 4 Low- And Middle-Income Countries And Associations With Birth Outcomes: A Secondary Analysis Of The Women First Trial., Melissa S Bauserman, Carla M Bann, K Michael Hambidge, Ana L Garces, Lester Figueroa, Jamie L Westcott, Jackie K Patterson, Elizabeth M Mcclure, Vanessa R Thorsten, Sumera Ali Aziz, Sarah Saleem, Robert L Goldenberg, Richard Derman, Veena Herekar, Manjunath Somannavar, Marion W Koso-Thomas, Adrien L Lokangaka, Antoinette K Tshefu, Nancy F Krebs, Carl L Bose, Shivaprasad Goudar, Sangappa Dhaded, Bhalchandra Kodkany, Omrana Pasha, Abhik Das, Menachem Miodovnik, N K Raju Tonse
Global Health Articles
BACKGROUND: Adequate gestational weight gain (GWG) is essential for healthy fetal growth. However, in low- and middle-income countries, where malnutrition is prevalent, little information is available about GWG and how it might be modified by nutritional status and interventions.
OBJECTIVE: We describe GWG and its associations with fetal growth and birth outcomes. We also examined the extent to which prepregnancy BMI, and preconception and early weight gain modify GWG, and its effects on fetal growth.
METHODS: This was a secondary analysis of the Women First Trial, including 2331 women within the Democratic Republic of Congo (DRC), Guatemala, India, and Pakistan ...
Effects Of Social Determinants Of Health In Progression To Type 2 Diabetes, 2021 University of Tennessee Health Science Center
Effects Of Social Determinants Of Health In Progression To Type 2 Diabetes, Folabi I. Ariganjoye
Applied Research Projects
The prevalence of prediabetes and diabetes in the United States and around the world has increased faster than expected in the last 30 years. The economic burden this costs a nation can be astronomic both in terms of expense and loss in productivity. One-third of U.S. adults, 86 million people, have prediabetes. Effective management is needed that can reach these 86 million, and others at high risk, to reduce their progression to diagnosed Type 2 diabetes. After the literature review, there was not enough literature to support how these led to the progression to diabetes. The abundant literature is ...
The Effect Of Polyunsaturated And Saturated Fatty Acids On Seizure Presence And Severity In A Cohort Of Subjects In An Epilepsy Monitoring Unit, 2021 University of Nebraska Medical Center
The Effect Of Polyunsaturated And Saturated Fatty Acids On Seizure Presence And Severity In A Cohort Of Subjects In An Epilepsy Monitoring Unit, Jana K. Wells
Theses & Dissertations
Ketogenic diet therapies (KDTs) have been used to treat epilepsy for nearly 100 years. Although effective, restrictive diet patterns and unknown impacts on long-term health outcomes often prevent their use as first-line therapy. To date, a distinct mechanism of action for KDTs has not been determined and evidence suggests fatty acids (FAs) may play a role in eliciting anti-seizure effects. This dissertation aimed to provide insights into the effect of polyunsaturated fatty acids (PUFAs) and saturated fatty acids (SFAs) on seizure presence and severity through the analysis of dietary intake in a cohort of patients admitted to an epilepsy monitoring ...
Fucoxanthin: A Review Of Potential Benefits Relative To Human Health, 2021 James Madison University
Fucoxanthin: A Review Of Potential Benefits Relative To Human Health, Michael White
Masters Theses, 2020-current
Fucoxanthin is a carotenoid sourced and extracted mainly from dark orange and brown seaweeds found in the pacific ocean, such as the wakame algae. The allenic bonds and unique oxygen groups give fucoxanthin its unique structure and are thought to be part of the reason fucoxanthin has unique physiological functions. Fucoxanthin has potentially numerous effects on the physiology of human health, ranging from skin health to metabolic health, which have been demonstrated in animal model research. The goal of this review is to examine current literature to discuss fucoxanthin’s potential application as a nutraceutical, treatment for obesity, type 2 ...
Sarcopenia Screening By Registered Dietitian Nutritionists (Rdns) In The United States (U.S.), 2021 East Tennessee State University
Sarcopenia Screening By Registered Dietitian Nutritionists (Rdns) In The United States (U.S.), Madison Marcom
Electronic Theses and Dissertations
Sarcopenia is a disease of muscle wasting primarily seen in older adults. Although this term was first coined over three decades ago, there is a lack of consensus on a definition, screening criteria, and treatment protocol for sarcopenia. The primary purpose of this study is to determine whether registered dietitian nutritionists (RDNs) in the United States (U.S.) screen for sarcopenia. Study participants were recruited through a randomized email list and included RDNs throughout the U.S. Respondents completed a survey questioning knowledge of sarcopenia, screening tools and company protocols in place, and the need and desire for sarcopenia education ...
Assessing And Comparing Quality Of Life Scores In Patients With Irritable Bowel Syndrome-Diarrhea, Irritable Irritable Bowel Syndrome-Constipation, And Irritable Bowel Syndrome-Mixed, 2021 Louisiana Tech University
Assessing And Comparing Quality Of Life Scores In Patients With Irritable Bowel Syndrome-Diarrhea, Irritable Irritable Bowel Syndrome-Constipation, And Irritable Bowel Syndrome-Mixed, Hailey Rentz
Irritable bowel syndrome (IBS) is a common gastrointestinal (GI) disorder that affects an estimated 1 in 10 people globally (Black & Ford, 2020). Since IBS is such a common GI disorder worldwide it is important to understand that impact it has on quality of life. This study assessed the differences in the effects of IBS on the quality of life in patients with each of the three types of IBS: IBS-D, IBS-C, and IBS-M. Potential respondents were recruited via social media using an online survey, which collected demographics and assessed the effects of IBS on quality of life. The survey was also emailed to FODMAP trained dietitians who were asked to share the survey with their patients. Data collection lasted for approximately 9 weeks. One hundred and ninety-two responses were analyzed. Descriptive statistics for demographic data were reported as frequencies and correlated to the quality of life subscale scores. An ANOVA was used to analyze the differences between the total quality of life scores and subscale scores among patients with IBS-D, IBS-C, and IBS-M. An ANOVA was also used to analyze the differences between total quality of life scores among the different races, education levels, and monthly spending on IBS. A t-test was used to analyze the differences between quality of life subscale scores among female and male patients. A p-value ≤ 0.05 indicated significance. A significant difference in total quality of life scores was found between groups based on how much money participants spend monthly on treatments for/managing their IBS symptoms (F(4, 149)= 10.81, p= <0.01). Significant differences were found in quality of life subscales scores among IBS-M, IBS-C, and IBS-D patients in the interference with activities (F(3, 178)= 5.83, p= 0.001), body image (F(3, 185)= 3.61, p= 0.014), and health worry subscales (F(3, 183)= 4.83, p= 0.003). Significant differences were also found in quality of life subscale scores among white, non-Hispanic; whites, Hispanic origin; and others (Native Americans, Asian/Pacific Islanders, multi-racial, and Asian Indians) in the dysphoria (F(2, 181)= 3.86, p= 0.23), social reaction (F(2, 182)= 3.23, p= 0.42), and relationships subscales (F(2, 184)= 3.58, p= 0.030). Further research is needed to validate these associations.
Categorization Of Orthologous Gene Clusters In 92 Ascomycota Genomes Reveals Functions Important For Phytopathogenicity, 2021 Northern Illinois University
Categorization Of Orthologous Gene Clusters In 92 Ascomycota Genomes Reveals Functions Important For Phytopathogenicity, Daniel Peterson, Tang Li, Ana M. Calvo, Yanbin Yin
Food for Health Papers & Publications
Phytopathogenic Ascomycota are responsible for substantial economic losses each year, destroying valuable crops. The present study aims to provide new insights into phytopathogenicity in Ascomycota from a comparative genomic perspective. This has been achieved by categorizing orthologous gene groups (orthogroups) from 68 phytopathogenic and 24 non-phytopathogenic Ascomycota genomes into three classes: Core, (pathogen or non-pathogen) group-specific, and genome-specific accessory orthogroups. We found that (i) ~20% orthogroups are group-specific and accessory in the 92 Ascomycota genomes, (ii) phytopathogenicity is not phylogenetically determined, (iii) group-specific orthogroups have more enriched functional terms than accessory orthogroups and this trend is particularly evident in phytopathogenic ...
The Crosstalk Between Insulin Resistance, Systemic Inflammation, Redox Imbalance And The Thyroid In Subjects With Obesity, 2021 IULIU HAŢIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF ENDOCRINOLOGY, CLUJ-NAPOCA, ROMANIA
The Crosstalk Between Insulin Resistance, Systemic Inflammation, Redox Imbalance And The Thyroid In Subjects With Obesity, Nicoleta Răcătăianu, Nicoleta Valentina Leach, Sorana D. Bolboacă, Maria Loredana Soran, Mirela Flonta, Ana Valea, Andrada-Luciana Lazăr, Cristina Ghervan
Journal of Mind and Medical Sciences
We aimed at assessing the interaction between visceral adipose tissue (VAT), insulin resistance (IR), circulating levels of monocyte chemoattractant protein-1 (MCP-1) and malondialdehyde (MDA) and the thyroid parameters in obese subjects. Methods. Obese subjects without thyroid pathologies or diseases associated with systemic inflammation and OS were recruited. Insulinemia, visceral fat thickness, metabolic and thyroid parameters were assayed. Circulating levels of MCP-1 and MDA were used to quantify inflammation and OS. Results. A number of 160 obese subjects were included. The MCP-1 level increased with the degree of obesity and HOMA-IR. MCP 1 was positively associated with antithyroperoxidase antibody (TPOab) levels ...
Linking The Brain And Bone Through Fat, 2021 CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY, BUCHAREST, ROMANIA
Linking The Brain And Bone Through Fat, Elisabeta Malinici, Anca Sirbu, Miruna Popa, Simona Fica
Journal of Mind and Medical Sciences
Over the past years, bone and adipose tissue have gained interest from researchers in the light of their secretory profiles, being able to produce active molecules, with the final effect of regulating energy homeostasis. Both adipocytes and osteoblasts originate in the pluripotent mesenchymal stem cell and this common origin has been proposed as the core of the fat-bone relationship. The central nervous system might be the third player in this association, capable of integrating signals. Numerous adipose tissue secreted factors that influence energy homeostasis and bone have been described: leptin, adiponectin, lipocalin 2, and inflammatory cytokines (e.g. IL-1, IL-6 ...
Alcohol Consumption And Cognitive Aging: Can It Be Beneficial?, 2021 MEDICAL UNIVERSITY PROF. DR. PARASKEV STOYANOV, DEPARTMENT OF PHYSIOLOGY AND PATHOPHYSIOLOGY, VARNA, BULGARIA
Alcohol Consumption And Cognitive Aging: Can It Be Beneficial?, Margarita Velikova, Bistra Galunska, Raya Dimitrova, Zlatislav Stoyanov
Journal of Mind and Medical Sciences
We present a literature review which summarizes the data supporting one of the alternative perspectives on the effect of alcohol consumption on cognitive aging – the possible positive effect of low to moderate drinking. Some of the main theories about aging, the mechanisms of brain aging, and the pathogenesis of cognitive decline and dementia are briefly described. In this context, the putative mechanisms of the protective action of non-alcoholic components in alcoholic beverages or low doses of ethanol against oxidative stress, inflammation, mitochondrial dysfunction, brain insulin resistance, and production of amyloid-β peptides are presented. The review article does not favor the ...
Corruption In Capsules: How It Is Legal For Companies To Put Harmful Ingredients In Vitamins And Dietary Supplements, 2021 Kutztown University of Pennsylvania
Corruption In Capsules: How It Is Legal For Companies To Put Harmful Ingredients In Vitamins And Dietary Supplements, Emily Leggiero
English Department: Research for Change - Wicked Problems in Our World
The vitamin and supplement industry has increased exponentially in profits as well as potential products on the market since the turn of the century. However, these products are not regulated, nor do they undergo any premarket clinical research or testing. Public health is compromised by vitamins and supplements that are available for American consumption that is disproportionately unregulated to their chemically similar counterparts. This wicked problem is facilitated through the combination of historical legislative definitions that has since been distorted for corrupt administrative gain through the allotment of corporate expenditures. Company disbursements are made to the same policymakers that create ...
Ketogenic Diet As A Preventative Measure Or Treatment Option For Osteoarthritistargeting Nfl Athletes As A High-Risk Group, 2021 Southeastern University - Lakeland
Ketogenic Diet As A Preventative Measure Or Treatment Option For Osteoarthritistargeting Nfl Athletes As A High-Risk Group, Kelsi J. Smith
Selected Honors Theses
Osteoarthritis (OA) is a prevalent joint disease that results from the degradation of articular cartilage, leading to inflammation, pain, and eventual joint failure. At one time, it was thought that OA was only the result of the natural decline experienced in old age; however, various risk factors have now been identified that may contribute to an increased risk for developing OA. Risk factors may include joint loading, altered biomechanics, obesity, and joint injury, to which athletes are exposed at a high rate. NFL athletes are one group of athletes that have continued to show a high prevalence of arthritis in ...
Effects Of Neonatal Nutrition Interventions On Neonatal Mortality And Child Health And Development Outcomes: A Systematic Review, 2021 SUNY Upstate Medical University
Effects Of Neonatal Nutrition Interventions On Neonatal Mortality And Child Health And Development Outcomes: A Systematic Review, Aamer Imdad, Faseeha Rehman, Evans Davis, Deepika Ranjit, Gamael S. S. Surin, Suzanna L. Attia, Sarah Lawler, Abigail A. Smith, Zulfiqar A. Bhutta
Pediatrics Faculty Publications
The last two decades have seen a significant decrease in mortality for children < 5 years of age in low and middle‐income countries (LMICs); however, neonatal (age, 0–28 days) mortality has not decreased at the same rate. We assessed three neonatal nutritional interventions that have the potential of reducing morbidity and mortality during infancy in LMICs.
To determine the efficacy and effectiveness of synthetic vitamin A, dextrose oral gel, and probiotic supplementation during the neonatal period.
We conducted electronic searches for relevant studies on the following databases: PubMed, CINAHL, LILACS, SCOPUS, and CENTRAL, Cochrane Central Register for Controlled Trials, up to November 27, 2019.
We aimed to include randomized and quasi‐experimental studies. The target population was neonates in LMICs. The interventions included synthetic vitamin A supplementation, oral dextrose gel supplementation, and probiotic supplementation during the neonatal ...
Characterization Of Two Zygnema Strains (Zygnema Circumcarinatum Sag 698-1a And Sag 698-1b) And A Rapid Method To Estimate Nuclear Genome Size Of Zygnematophycean Green Algae, 2021 University of Nebraska-Lincoln
Characterization Of Two Zygnema Strains (Zygnema Circumcarinatum Sag 698-1a And Sag 698-1b) And A Rapid Method To Estimate Nuclear Genome Size Of Zygnematophycean Green Algae, Xuehuan Feng, Andreas Holzinger, Charlotte Permann, Dirk Anderson, Yanbin Yin
Food for Health Papers & Publications
Zygnematophyceae green algae (ZGA) have been shown to be the closest relatives of land plants. Three nuclear genomes (Spirogloea muscicola, Mesotaenium endlicherianum, and Penium margaritaceum) of ZGA have been recently published, and more genomes are underway. Here we analyzed two Zygnema circumcarinatum strains SAG 698-1a (mating +) and SAG 698-1b (mating −) and found distinct cell sizes and other morphological differences. The molecular identities of the two strains were further investigated by sequencing their 18S rRNA, psaA and rbcL genes. These marker genes of SAG 698-1a were surprisingly much more similar to Z. cylindricum (SAG 698-2) than to SAG 698-1b. Phylogenies of ...