Open Access. Powered by Scholars. Published by Universities.®

Medical Nutrition Commons

Open Access. Powered by Scholars. Published by Universities.®

325 Full-Text Articles 783 Authors 55205 Downloads 49 Institutions

All Articles in Medical Nutrition

Faceted Search

325 full-text articles. Page 1 of 10.

Pkm2 Influences The Metabolic Fate Of Butyrate In Colorectal Cancer Cells, Megan Louise Pence 2018 University of Tennessee, Knoxville

Pkm2 Influences The Metabolic Fate Of Butyrate In Colorectal Cancer Cells, Megan Louise Pence

University of Tennessee Honors Thesis Projects

No abstract provided.


The Effect Of Polyphenol-Rich Interventions On Cardiovascular Risk Factors In Haemodialysis: A Systematic Review And Meta-Analysii, Wolfgang Marx, Jaimon Kelly, Skye Marshall, Stacey Nakos, Katrina Campbell, Catherine Itsiopoulos 2017 Bond University; La Trobe University

The Effect Of Polyphenol-Rich Interventions On Cardiovascular Risk Factors In Haemodialysis: A Systematic Review And Meta-Analysii, Wolfgang Marx, Jaimon Kelly, Skye Marshall, Stacey Nakos, Katrina Campbell, Catherine Itsiopoulos

Faculty of Health Sciences & Medicine Publications

End-stage kidney disease is a strong risk factor for cardiovascular-specific mortality. Polyphenol-rich interventions may attenuate cardiovascular disease risk factors; however, this has not been systematically evaluated in the hemodialysis population. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the following databases were searched: Cochrane Library (http://www.cochranelibrary.com/), MEDLINE (https://health.ebsco.com/products/medline-with-full-text), Embase (https://www.elsevier.com/solutions/embase-biomedical-research), and CINAHL (https://www.ebscohost.com/nursing/products/cinahl-databases/cinahl-complete). Meta-analyses were conducted for measures of lipid profile, inflammation, oxidative stress, and blood pressure. Risk of bias was assessed using the Cochrane Collaboration ...


Alcohol And Cancer Stem Cells, Mei Xu, Jia Luo 2017 University of Kentucky

Alcohol And Cancer Stem Cells, Mei Xu, Jia Luo

Pharmacology and Nutritional Sciences Faculty Publications

Heavy alcohol consumption has been associated with increased risk of several cancers, including cancer of the colon, rectum, female breast, oral cavity, pharynx, larynx, liver, and esophagus. It appears that alcohol exposure not only promotes carcinogenesis but also enhances the progression and aggressiveness of existing cancers. The molecular mechanisms underlying alcohol tumor promotion, however, remain unclear. Cancer stem cells (CSC), a subpopulation of cancer cells with self-renewal and differentiation capacity, play an important role in tumor initiation, progression, metastasis, recurrence, and therapy resistance. The recent research evidence suggests that alcohol increases the CSC population in cancers, which may underlie alcohol-induced ...


Efficacy And Effectiveness Of Carnitine Supplementation For Cancer-Related Fatigue: A Systematic Literature Review And Meta-Analysis, Wolfgang Marx, Laisa Teleni, Rachelle S. Opie, Jaimon T Kelly, Skye Marshall, Catherine Itsiopoulos, Elisabeth A Isenring 2017 Bond University

Efficacy And Effectiveness Of Carnitine Supplementation For Cancer-Related Fatigue: A Systematic Literature Review And Meta-Analysis, Wolfgang Marx, Laisa Teleni, Rachelle S. Opie, Jaimon T Kelly, Skye Marshall, Catherine Itsiopoulos, Elisabeth A Isenring

Faculty of Health Sciences & Medicine Publications

Background Carnitine deficiency has been implicated as a potential pathway for cancer-related fatigue that could be treated with carnitine supplementation. The aim of this systematic literature review and meta-analysis was to evaluate the literature regarding the use of supplemental carnitine as a treatment for cancer-related fatigue.
Methods
Using the PRISMA guidelines, an electronic search of the Cochrane Library, MEDLINE, Embase, CINAHL and reference lists was conducted. Data were extracted and independently assessed for quality using the Academy of Nutrition and Dietetics evidence analysis by two reviewers. In studies with positive quality ratings, a meta-analysis was performed using the random-effects model ...


Deletion Of The Nr4a Nuclear Receptor Nor1 In Hematopoietic Stem Cells Reduces Inflammation But Not Abdominal Aortic Aneurysm Formation, Hua Qing, Karrie L. Jones, Elizabeth B. Heywood, Hong Lu, Alan Daugherty, Dennis Bruemmer 2017 University of Kentucky

Deletion Of The Nr4a Nuclear Receptor Nor1 In Hematopoietic Stem Cells Reduces Inflammation But Not Abdominal Aortic Aneurysm Formation, Hua Qing, Karrie L. Jones, Elizabeth B. Heywood, Hong Lu, Alan Daugherty, Dennis Bruemmer

Pharmacology and Nutritional Sciences Faculty Publications

Background: The NR4A3 orphan nuclear hormone receptor, NOR1, functions as a constitutively active transcription factor to regulate inflammation, proliferation, and cell survival during pathological vascular remodeling. Inflammatory processes represent key mechanisms leading to abdominal aortic aneurysm (AAA) formation. However, a role of NOR1 in AAA formation has not been investigated previously.

Methods: Inflammatory gene expression was analyzed in bone marrow-derived macrophages isolated from NOR1-deficient mice. Low-density lipoprotein receptor-deficient (LDLr−/−) mice were irradiated and reconstituted with hematopoietic stem cells obtained from NOR1−/− or wild-type littermate mice. Animals were infused with angiotensin II and fed a diet enriched in saturated fat to ...


Different Effects Of Maternal Low-Isoflavone Soy Protein And Genistein Consumption On Hepatic Lipid Metabolism Of 21-Day-Old Male Rat Offspring., Anna Han, Sae Bom Won, Young Hye Kwon 2017 Seoul National University; Thomas Jefferson University

Different Effects Of Maternal Low-Isoflavone Soy Protein And Genistein Consumption On Hepatic Lipid Metabolism Of 21-Day-Old Male Rat Offspring., Anna Han, Sae Bom Won, Young Hye Kwon

Department of Cancer Biology Faculty Papers

Amino acid composition and isoflavone are alleged contributors to the beneficial effects of soy protein isolate (SPI) on lipid metabolism. Therefore, we investigated the contributing component(s) of SPI in a maternal diet to the regulation of lipid metabolism in offspring. We also determined serum parameters in dams to investigate specific maternal cues that might be responsible for this regulation. Female rats were fed either a casein (CAS), a low-isoflavone SPI, or a casein plus genistein (GEN, 250 mg/kg) diet for two weeks before mating, as well as during pregnancy and lactation. Male offspring (CAS, SPI and GEN groups ...


The Effect Of A Standardized Ginger Extract On Chemotherapy-Induced Nausea-Related Quality Of Life In Patients Undergoing Moderately Or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial, Wolfgang Marx, Alexandra L McCarthy, Karin Ried, Dan McKavanagh, Luis Vitetta, Avni Sali, Anna Lohning, Elisabeth Isenring 2017 Bond University; La Trobe University; Princess Alexandra Hospital Brisbane

The Effect Of A Standardized Ginger Extract On Chemotherapy-Induced Nausea-Related Quality Of Life In Patients Undergoing Moderately Or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial, Wolfgang Marx, Alexandra L Mccarthy, Karin Ried, Dan Mckavanagh, Luis Vitetta, Avni Sali, Anna Lohning, Elisabeth Isenring

Faculty of Health Sciences & Medicine Publications

Ginger supplementation could be an effective adjuvant treatment for chemotherapy-induced nausea (CIN). The aim of this clinical trial was to address significant methodological limitations in previous trials. Patients (N = 51) were randomly allocated to receive either 1.2 g of standardised ginger extract or placebo per day, in addition to standard anti-emetic therapy, during the first three cycles of chemotherapy. The primary outcome was CIN-related quality of life (QoL) measured with the Functional Living Index- Emesis (FLIE) questionnaire. Secondary outcomes included acute and delayed nausea, vomiting, and retching as well as cancer-related fatigue, nutritional status, and CIN and vomiting-specific prognostic ...


Optimizing Heart Failure Outcomes Through Diet: A Review, Farley B. Neasman III 2017 Marshall University Cardiology

Optimizing Heart Failure Outcomes Through Diet: A Review, Farley B. Neasman Iii

Marshall Journal of Medicine

Heart failure is a growing epidemic that will add significant monetary and human costs to an already overtaxed health-care system. Though promising new medications have recently been approved, this complex condition is largely preventable through aggressive risk factor modification, with diet being shown to have a greater effect than exercise. An underrated component of a healthy diet is the simple addition of nuts – the anti-inflammatory fatty acids, healthy proteins, and general availability have been shown to improve survival and reduce the primary risk factors contributing to heart failure, making the addition of nuts and legumes to the diet an attractive ...


Changes In Dietary Patterns And Body Composition Within 12 Months Of Liver Transplantation, McCoy Simone, Katrina Campbell, Annie-Claude Lassemillante, Matthew P. Wallen, Jonathan Fawcett, Maree Jarrett, Graeme A. Macdonald, Ingrid J. Hickman 2017 Princess Alexandra Hospital Brisbane

Changes In Dietary Patterns And Body Composition Within 12 Months Of Liver Transplantation, Mccoy Simone, Katrina Campbell, Annie-Claude Lassemillante, Matthew P. Wallen, Jonathan Fawcett, Maree Jarrett, Graeme A. Macdonald, Ingrid J. Hickman

Katrina Campbell

Background:

Cardiometabolic risk factors are increasing in liver transplant recipients (LTR). Influencing dietary factors have not been assessed. The aim of this observational study was to assess changes in weight, metabolic function, dietary intake and eating behaviours in the first year after orthotopic liver transplantation (OLT).

Methods:

Consecutive recruitment of 17 patients (14 males) awaiting OLT at a single tertiary hospital. Dietary intake, food behaviours and anthropometry were recorded at baseline, and 6 and 12 months post-transplant.

Results:

By 12 months, patients had gained on average 7.3% of body weight. The prevalence of overweight or obesity increased from baseline ...


Vitamin D Supplementation In Allo-Hsct Patients, Bailey Nelson 2017 University of Nebraska Medical Center

Vitamin D Supplementation In Allo-Hsct Patients, Bailey Nelson

Theses & Dissertations

BACKGROUND: Bone health is a serious concern for long-term survivors of Allo-HSCT due to multiple risk factors including steroids, chemotherapy, immunosuppressive drugs, and poor nutrition status1. Steroids have been long proven to have negative impact on bone health and the National Osteoporosis Foundation (NOF) lists steroids as a contributing factor to osteoporosis and fractures. NOF guidelines recommend providing adequate daily vitamin D as a safe and inexpensive way to help reduce fracture risk1. Therefore, proper supplementation of vitamin D may increase the quality of life for patients post Allo-HSCT.

PURPOSE: The purpose of this study is to determine if Allo-HSCT ...


Compliance With Dietary Guidelines Affects Capillary Recruitment In Healthy Middle-Aged Men And Women, Virginia Govoni, Thomas A B Sanders, Dianne P Reidlinger, Julia Darzi, Sarah E E Berry, Louise M Goff, Paul T Seed, Philip J Chowienczyk, Wendy L Hall 2017 King's College London

Compliance With Dietary Guidelines Affects Capillary Recruitment In Healthy Middle-Aged Men And Women, Virginia Govoni, Thomas A B Sanders, Dianne P Reidlinger, Julia Darzi, Sarah E E Berry, Louise M Goff, Paul T Seed, Philip J Chowienczyk, Wendy L Hall

Faculty of Health Sciences & Medicine Publications

PURPOSE:

Healthy microcirculation is important to maintain the health of tissues and organs, most notably the heart, kidney and retina. Single components of the diet such as salt, lipids and polyphenols may influence microcirculation, but the effects of dietary patterns that are consistent with current dietary guidelines are uncertain. It was hypothesized that compliance to UK dietary guidelines would have a favourable effect on skin capillary density/recruitment compared with a traditional British diet (control diet).

METHODS:

A 12-week randomized controlled trial in men and women aged 40-70 years was used to test whether skin microcirculation, measured by skin video-capillaroscopy ...


The Host Microbiome Regulates And Maintains Human Health: A Primer And Perspective For Non-Microbiologists, Sunil Thomas, Jacques Izard, Emily Walsh, Kristen Batich, Pakawat Chongsathidkiet, Gerard Clarke, David A. Sela, Alexander J. Muller, James M. Mullin, Korin Albert, John P. Gilligan, Katherine DiGuilio, Rima Dilbarova, Walker Alexander, George P. Prendergast 2017 Lankenau Institute for Medical Research, Wynnewood, Pennsylvania

The Host Microbiome Regulates And Maintains Human Health: A Primer And Perspective For Non-Microbiologists, Sunil Thomas, Jacques Izard, Emily Walsh, Kristen Batich, Pakawat Chongsathidkiet, Gerard Clarke, David A. Sela, Alexander J. Muller, James M. Mullin, Korin Albert, John P. Gilligan, Katherine Diguilio, Rima Dilbarova, Walker Alexander, George P. Prendergast

Faculty Publications in Food Science and Technology

Humans consider themselves discrete autonomous organisms, but recent research is rapidly strengthening the appreciation that associated microorganisms make essential contributions to human health and well being. Each person is inhabited and also surrounded by his/her own signature microbial cloud. A low diversity of microorganisms is associated with a plethora of diseases, including allergy, diabetes, obesity, arthritis, inflammatory bowel diseases, and even neuropsychiatric disorders. Thus, an interaction of microorganisms with the host immune system is required for a healthy body. Exposure to microorganisms from the moment we are born and appropriate microbiome assembly during childhood are essential for establishing an ...


Dub3 Inhibition Suppresses Breast Cancer Invasion And Metastasis By Promoting Snail1 Degradation, Yadi Wu, Yu Wang, Yiwei Lin, Yajuan Liu, Yifan Wang, Jianhang Jia, Puja Singh, Young-In Chi, Chi Wang, Chenfang Dong, Wei Li, Min Tao, Dana L. Napier, Qiuying Shi, Jiong Deng, B. Mark Evers, Binhua P. Zhou 2017 University of Kentucky

Dub3 Inhibition Suppresses Breast Cancer Invasion And Metastasis By Promoting Snail1 Degradation, Yadi Wu, Yu Wang, Yiwei Lin, Yajuan Liu, Yifan Wang, Jianhang Jia, Puja Singh, Young-In Chi, Chi Wang, Chenfang Dong, Wei Li, Min Tao, Dana L. Napier, Qiuying Shi, Jiong Deng, B. Mark Evers, Binhua P. Zhou

Pharmacology and Nutritional Sciences Faculty Publications

Snail1, a key transcription factor of epithelial–mesenchymal transition (EMT), is subjected to ubiquitination and degradation, but the mechanism by which Snail1 is stabilized in tumours remains unclear. We identify Dub3 as a bona fide Snail1 deubiquitinase, which interacts with and stabilizes Snail1. Dub3 is overexpressed in breast cancer; knockdown of Dub3 resulted in Snail1 destabilization, suppressed EMT and decreased tumour cell migration, invasion, and metastasis. These effects are rescued by ectopic Snail1 expression. IL-6 also stabilizes Snail1 by inducing Dub3 expression, the specific inhibitor WP1130 binds to Dub3 and inhibits the Dub3-mediating Snail1 stabilization in vitroand in vivo ...


Determination Of The Concentration Of Major Active Anti-Emetic Constituents Within Commercial Ginger Food Products And Dietary Supplements, Wolfgang Marx, Elisabeth A Isenring, Anna E. Lohning 2017 Bond University

Determination Of The Concentration Of Major Active Anti-Emetic Constituents Within Commercial Ginger Food Products And Dietary Supplements, Wolfgang Marx, Elisabeth A Isenring, Anna E. Lohning

Faculty of Health Sciences & Medicine Publications

Introduction

Studies suggest that the bioactive compounds contained within the rhizome of ginger (Zingiber officinale) could exert a beneficial effect on the symptoms of several chronic conditions (e.g. diabetes, arthritis) and in the reduction of nausea. However, it is unknown if ginger supplements and food products contain sufficient quantities of the necessary active ingredients to achieve a therapeutic effect.

This study analyzed twenty commercially available ginger products including ginger dietary supplements, ginger spices (ground dried ginger), and ginger-containing drinks and food products and determined the concentration of [6]-, [8]- and [10]- gingerol and [6]- and [10]-shogaol.

Methods

The ...


Inhibition Of The Integrin/Fak Signaling Axis And C-Myc Synergistically Disrupts Ovarian Cancer Malignancy, B. Xu, Jason R. Lefringhouse, Z. Liu, D. West, Lauren A. Baldwin, C. Ou, L. Chen, Dana L. Napier, Luksana Chaiswing, Lawrence D. Brewer, Daret K. St Clair, Olivier Thibault, John R. van Nagell, Binhua P. Zhou, R. Drapkin, J. -A. Huang, M. L. Lu, Frederick R. Ueland, X. H. Yang 2017 University of Kentucky

Inhibition Of The Integrin/Fak Signaling Axis And C-Myc Synergistically Disrupts Ovarian Cancer Malignancy, B. Xu, Jason R. Lefringhouse, Z. Liu, D. West, Lauren A. Baldwin, C. Ou, L. Chen, Dana L. Napier, Luksana Chaiswing, Lawrence D. Brewer, Daret K. St Clair, Olivier Thibault, John R. Van Nagell, Binhua P. Zhou, R. Drapkin, J. -A. Huang, M. L. Lu, Frederick R. Ueland, X. H. Yang

Pharmacology and Nutritional Sciences Faculty Publications

Integrins, a family of heterodimeric receptors for extracellular matrix, are promising therapeutic targets for ovarian cancer, particularly high-grade serous-type (HGSOC), as they drive tumor cell attachment, migration, proliferation and survival by activating focal adhesion kinase (FAK)-dependent signaling. Owing to the potential off-target effects of FAK inhibitors, disruption of the integrin signaling axis remains to be a challenge. Here, we tackled this barrier by screening for inhibitors being functionally cooperative with small-molecule VS-6063, a phase II FAK inhibitor. From this screening, JQ1, a potent inhibitor of Myc oncogenic network, emerged as the most robust collaborator. Treatment with a combination of ...


Translational Models For Vascular Cognitive Impairment: A Review Including Larger Species, Atticus H. Hainsworth, Stuart M. Allan, Johannes Boltze, Catriona Cunningham, Chad Farris, Elizabeth Head, Masafumi Ihara, Jeremy D. Isaacs, Raj N. Kalaria, Saskia A. M. J. Lesnik Oberstein, Mark B. Moss, Björn Nitzsche, Gary A. Rosenberg, Julie W. Rutten, Melita Salkovic-Petrisic, Aron M. Troen 2017 St George’s University of London, UK

Translational Models For Vascular Cognitive Impairment: A Review Including Larger Species, Atticus H. Hainsworth, Stuart M. Allan, Johannes Boltze, Catriona Cunningham, Chad Farris, Elizabeth Head, Masafumi Ihara, Jeremy D. Isaacs, Raj N. Kalaria, Saskia A. M. J. Lesnik Oberstein, Mark B. Moss, Björn Nitzsche, Gary A. Rosenberg, Julie W. Rutten, Melita Salkovic-Petrisic, Aron M. Troen

Pharmacology and Nutritional Sciences Faculty Publications

Background: Disease models are useful for prospective studies of pathology, identification of molecular and cellular mechanisms, pre-clinical testing of interventions, and validation of clinical biomarkers. Here, we review animal models relevant to vascular cognitive impairment (VCI). A synopsis of each model was initially presented by expert practitioners. Synopses were refined by the authors, and subsequently by the scientific committee of a recent conference (International Conference on Vascular Dementia 2015). Only peer-reviewed sources were cited.

Methods: We included models that mimic VCI-related brain lesions (white matter hypoperfusion injury, focal ischaemia, cerebral amyloid angiopathy) or reproduce VCI risk factors (old age, hypertension ...


Which Food Security Determinants Predict Adequate Vegetable Consumption Among Rural Western Australian Children?, Stephanie L. Godrich, Johnny Lo, Christina R. Davies, Jill Darby, Amanda Devine 2017 Edith Cowan University

Which Food Security Determinants Predict Adequate Vegetable Consumption Among Rural Western Australian Children?, Stephanie L. Godrich, Johnny Lo, Christina R. Davies, Jill Darby, Amanda Devine

ECU Publications Post 2013

Improving the suboptimal vegetable consumption among the majority of Australian children is imperative in reducing chronic disease risk. The objective of this research was to determine whether there was a relationship between food security determinants (FSD) (i.e., food availability, access, and utilisation dimensions) and adequate vegetable consumption among children living in regional and remote Western Australia (WA). Caregiver-child dyads (n = 256) living in non-metropolitan/rural WA completed cross-sectional surveys that included questions on FSD, demographics and usual vegetable intake. A total of 187 dyads were included in analyses, which included descriptive and logistic regression analyses via IBM SPSS (version ...


Developing Consensus On The Strategic Priorities For The Prevention Of Obesity Amongst The Australian Population., Emily Haynes 2017 Bond University

Developing Consensus On The Strategic Priorities For The Prevention Of Obesity Amongst The Australian Population., Emily Haynes

Theses

Previous research has identified key barriers to obesity-related policy implementation internationally and in Australia. Food industry stakeholders emphasise the lack of evidence and propose ethical concerns of a ‘nanny state’ around population-wide policies to regulate obesogenic environments, undermining public and political support for government intervention. Policy framing, and public and political support are essential for successful policy adoption, and collaborative research is essential to strengthen pathways to action. This thesis describes a body of research that is concerned with how governments can influence choice through obesity-related policy, with a specific focus on the concepts of policy intrusiveness and impact to ...


Changes In Dietary Patterns And Body Composition Within 12 Months Of Liver Transplantation, McCoy Simone, Katrina Campbell, Annie-Claude Lassemillante, Matthew P. Wallen, Jonathan Fawcett, Maree Jarrett, Graeme A. Macdonald, Ingrid J. Hickman 2017 Princess Alexandra Hospital Brisbane

Changes In Dietary Patterns And Body Composition Within 12 Months Of Liver Transplantation, Mccoy Simone, Katrina Campbell, Annie-Claude Lassemillante, Matthew P. Wallen, Jonathan Fawcett, Maree Jarrett, Graeme A. Macdonald, Ingrid J. Hickman

Faculty of Health Sciences & Medicine Publications

Background:

Cardiometabolic risk factors are increasing in liver transplant recipients (LTR). Influencing dietary factors have not been assessed. The aim of this observational study was to assess changes in weight, metabolic function, dietary intake and eating behaviours in the first year after orthotopic liver transplantation (OLT).

Methods:

Consecutive recruitment of 17 patients (14 males) awaiting OLT at a single tertiary hospital. Dietary intake, food behaviours and anthropometry were recorded at baseline, and 6 and 12 months post-transplant.

Results:

By 12 months, patients had gained on average 7.3% of body weight. The prevalence of overweight or obesity increased from baseline ...


Amphetamine-Like Compounds In Pre-Workout Supplements, Andy Hsien Wei Koh 2017 Bond University

Amphetamine-Like Compounds In Pre-Workout Supplements, Andy Hsien Wei Koh

Theses

Pre-workout supplements (PWS), like most nutritional supplements, are classified by the Therapeutic Goods Administration (TGA) in Australia as complementary medicines and are therefore subject to much less stringent regulation compared to pharmaceuticals. Complementary medicines (also known as 'traditional' or 'alternative' medicines) include vitamin, mineral, herbal, aromatherapy and homoeopathic products. The overall goal of this thesis was to determine the amounts of stimulants in PWS, both the biogenic amines derived from Citrus aurantium (CA) extracts as well as caffeine and its dimethylxanthine (DMX) derivatives. Research questions have been put forward relating to the components within PWS and whether they comply with ...


Digital Commons powered by bepress