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Efficacy And Effectiveness Of Carnitine Supplementation For Cancer-Related Fatigue: A Systematic Literature Review And Meta-Analysis, Wolfgang Marx, Laisa Teleni, Rachelle S. Opie, Jaimon T Kelly, Skye Marshall, Catherine Itsiopoulos, Elisabeth A Isenring 2017 Bond University

Efficacy And Effectiveness Of Carnitine Supplementation For Cancer-Related Fatigue: A Systematic Literature Review And Meta-Analysis, Wolfgang Marx, Laisa Teleni, Rachelle S. Opie, Jaimon T Kelly, Skye Marshall, Catherine Itsiopoulos, Elisabeth A Isenring

Faculty of Health Sciences & Medicine Publications

Background Carnitine deficiency has been implicated as a potential pathway for cancer-related fatigue that could be treated with carnitine supplementation. The aim of this systematic literature review and meta-analysis was to evaluate the literature regarding the use of supplemental carnitine as a treatment for cancer-related fatigue.
Methods
Using the PRISMA guidelines, an electronic search of the Cochrane Library, MEDLINE, Embase, CINAHL and reference lists was conducted. Data were extracted and independently assessed for quality using the Academy of Nutrition and Dietetics evidence analysis by two reviewers. In studies with positive quality ratings, a meta-analysis was performed using the random-effects model ...


Different Effects Of Maternal Low-Isoflavone Soy Protein And Genistein Consumption On Hepatic Lipid Metabolism Of 21-Day-Old Male Rat Offspring., Anna Han, Sae Bom Won, Young Hye Kwon 2017 Seoul National University; Thomas Jefferson University

Different Effects Of Maternal Low-Isoflavone Soy Protein And Genistein Consumption On Hepatic Lipid Metabolism Of 21-Day-Old Male Rat Offspring., Anna Han, Sae Bom Won, Young Hye Kwon

Department of Cancer Biology Faculty Papers

Amino acid composition and isoflavone are alleged contributors to the beneficial effects of soy protein isolate (SPI) on lipid metabolism. Therefore, we investigated the contributing component(s) of SPI in a maternal diet to the regulation of lipid metabolism in offspring. We also determined serum parameters in dams to investigate specific maternal cues that might be responsible for this regulation. Female rats were fed either a casein (CAS), a low-isoflavone SPI, or a casein plus genistein (GEN, 250 mg/kg) diet for two weeks before mating, as well as during pregnancy and lactation. Male offspring (CAS, SPI and GEN groups ...


The Effect Of A Standardized Ginger Extract On Chemotherapy-Induced Nausea-Related Quality Of Life In Patients Undergoing Moderately Or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial, Wolfgang Marx, Alexandra L McCarthy, Karin Ried, Dan McKavanagh, Luis Vitetta, Avni Sali, Anna Lohning, Elisabeth Isenring 2017 Bond University; La Trobe University; Princess Alexandra Hospital Brisbane

The Effect Of A Standardized Ginger Extract On Chemotherapy-Induced Nausea-Related Quality Of Life In Patients Undergoing Moderately Or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial, Wolfgang Marx, Alexandra L Mccarthy, Karin Ried, Dan Mckavanagh, Luis Vitetta, Avni Sali, Anna Lohning, Elisabeth Isenring

Faculty of Health Sciences & Medicine Publications

Ginger supplementation could be an effective adjuvant treatment for chemotherapy-induced nausea (CIN). The aim of this clinical trial was to address significant methodological limitations in previous trials. Patients (N = 51) were randomly allocated to receive either 1.2 g of standardised ginger extract or placebo per day, in addition to standard anti-emetic therapy, during the first three cycles of chemotherapy. The primary outcome was CIN-related quality of life (QoL) measured with the Functional Living Index- Emesis (FLIE) questionnaire. Secondary outcomes included acute and delayed nausea, vomiting, and retching as well as cancer-related fatigue, nutritional status, and CIN and vomiting-specific prognostic ...


Optimizing Heart Failure Outcomes Through Diet: A Review, Farley B. Neasman III 2017 Marshall University Cardiology

Optimizing Heart Failure Outcomes Through Diet: A Review, Farley B. Neasman Iii

Marshall Journal of Medicine

Heart failure is a growing epidemic that will add significant monetary and human costs to an already overtaxed health-care system. Though promising new medications have recently been approved, this complex condition is largely preventable through aggressive risk factor modification, with diet being shown to have a greater effect than exercise. An underrated component of a healthy diet is the simple addition of nuts – the anti-inflammatory fatty acids, healthy proteins, and general availability have been shown to improve survival and reduce the primary risk factors contributing to heart failure, making the addition of nuts and legumes to the diet an attractive ...


Changes In Dietary Patterns And Body Composition Within 12 Months Of Liver Transplantation, McCoy Simone, Katrina Campbell, Annie-Claude Lassemillante, Matthew P. Wallen, Jonathan Fawcett, Maree Jarrett, Graeme A. Macdonald, Ingrid J. Hickman 2017 Princess Alexandra Hospital Brisbane

Changes In Dietary Patterns And Body Composition Within 12 Months Of Liver Transplantation, Mccoy Simone, Katrina Campbell, Annie-Claude Lassemillante, Matthew P. Wallen, Jonathan Fawcett, Maree Jarrett, Graeme A. Macdonald, Ingrid J. Hickman

Katrina Campbell

Background:

Cardiometabolic risk factors are increasing in liver transplant recipients (LTR). Influencing dietary factors have not been assessed. The aim of this observational study was to assess changes in weight, metabolic function, dietary intake and eating behaviours in the first year after orthotopic liver transplantation (OLT).

Methods:

Consecutive recruitment of 17 patients (14 males) awaiting OLT at a single tertiary hospital. Dietary intake, food behaviours and anthropometry were recorded at baseline, and 6 and 12 months post-transplant.

Results:

By 12 months, patients had gained on average 7.3% of body weight. The prevalence of overweight or obesity increased from baseline ...


Vitamin D Supplementation In Allo-Hsct Patients, Bailey Nelson 2017 University of Nebraska Medical Center

Vitamin D Supplementation In Allo-Hsct Patients, Bailey Nelson

Theses & Dissertations

BACKGROUND: Bone health is a serious concern for long-term survivors of Allo-HSCT due to multiple risk factors including steroids, chemotherapy, immunosuppressive drugs, and poor nutrition status1. Steroids have been long proven to have negative impact on bone health and the National Osteoporosis Foundation (NOF) lists steroids as a contributing factor to osteoporosis and fractures. NOF guidelines recommend providing adequate daily vitamin D as a safe and inexpensive way to help reduce fracture risk1. Therefore, proper supplementation of vitamin D may increase the quality of life for patients post Allo-HSCT.

PURPOSE: The purpose of this study is to determine if Allo-HSCT ...


Compliance With Dietary Guidelines Affects Capillary Recruitment In Healthy Middle-Aged Men And Women, Virginia Govoni, Thomas A B Sanders, Dianne P Reidlinger, Julia Darzi, Sarah E E Berry, Louise M Goff, Paul T Seed, Philip J Chowienczyk, Wendy L Hall 2017 King's College London

Compliance With Dietary Guidelines Affects Capillary Recruitment In Healthy Middle-Aged Men And Women, Virginia Govoni, Thomas A B Sanders, Dianne P Reidlinger, Julia Darzi, Sarah E E Berry, Louise M Goff, Paul T Seed, Philip J Chowienczyk, Wendy L Hall

Faculty of Health Sciences & Medicine Publications

PURPOSE:

Healthy microcirculation is important to maintain the health of tissues and organs, most notably the heart, kidney and retina. Single components of the diet such as salt, lipids and polyphenols may influence microcirculation, but the effects of dietary patterns that are consistent with current dietary guidelines are uncertain. It was hypothesized that compliance to UK dietary guidelines would have a favourable effect on skin capillary density/recruitment compared with a traditional British diet (control diet).

METHODS:

A 12-week randomized controlled trial in men and women aged 40-70 years was used to test whether skin microcirculation, measured by skin video-capillaroscopy ...


The Host Microbiome Regulates And Maintains Human Health: A Primer And Perspective For Non-Microbiologists, Sunil Thomas, Jacques Izard, Emily Walsh, Kristen Batich, Pakawat Chongsathidkiet, Gerard Clarke, David A. Sela, Alexander J. Muller, James M. Mullin, Korin Albert, John P. Gilligan, Katherine DiGuilio, Rima Dilbarova, Walker Alexander, George P. Prendergast 2017 Lankenau Institute for Medical Research, Wynnewood, Pennsylvania

The Host Microbiome Regulates And Maintains Human Health: A Primer And Perspective For Non-Microbiologists, Sunil Thomas, Jacques Izard, Emily Walsh, Kristen Batich, Pakawat Chongsathidkiet, Gerard Clarke, David A. Sela, Alexander J. Muller, James M. Mullin, Korin Albert, John P. Gilligan, Katherine Diguilio, Rima Dilbarova, Walker Alexander, George P. Prendergast

Faculty Publications in Food Science and Technology

Humans consider themselves discrete autonomous organisms, but recent research is rapidly strengthening the appreciation that associated microorganisms make essential contributions to human health and well being. Each person is inhabited and also surrounded by his/her own signature microbial cloud. A low diversity of microorganisms is associated with a plethora of diseases, including allergy, diabetes, obesity, arthritis, inflammatory bowel diseases, and even neuropsychiatric disorders. Thus, an interaction of microorganisms with the host immune system is required for a healthy body. Exposure to microorganisms from the moment we are born and appropriate microbiome assembly during childhood are essential for establishing an ...


Which Food Security Determinants Predict Adequate Vegetable Consumption Among Rural Western Australian Children?, Stephanie L. Godrich, Johnny Lo, Christina R. Davies, Jill Darby, Amanda Devine 2017 Edith Cowan University

Which Food Security Determinants Predict Adequate Vegetable Consumption Among Rural Western Australian Children?, Stephanie L. Godrich, Johnny Lo, Christina R. Davies, Jill Darby, Amanda Devine

ECU Publications Post 2013

Improving the suboptimal vegetable consumption among the majority of Australian children is imperative in reducing chronic disease risk. The objective of this research was to determine whether there was a relationship between food security determinants (FSD) (i.e., food availability, access, and utilisation dimensions) and adequate vegetable consumption among children living in regional and remote Western Australia (WA). Caregiver-child dyads (n = 256) living in non-metropolitan/rural WA completed cross-sectional surveys that included questions on FSD, demographics and usual vegetable intake. A total of 187 dyads were included in analyses, which included descriptive and logistic regression analyses via IBM SPSS (version ...


Developing Consensus On The Strategic Priorities For The Prevention Of Obesity Amongst The Australian Population., Emily Haynes 2017 Bond University

Developing Consensus On The Strategic Priorities For The Prevention Of Obesity Amongst The Australian Population., Emily Haynes

Theses

Previous research has identified key barriers to obesity-related policy implementation internationally and in Australia. Food industry stakeholders emphasise the lack of evidence and propose ethical concerns of a ‘nanny state’ around population-wide policies to regulate obesogenic environments, undermining public and political support for government intervention. Policy framing, and public and political support are essential for successful policy adoption, and collaborative research is essential to strengthen pathways to action. This thesis describes a body of research that is concerned with how governments can influence choice through obesity-related policy, with a specific focus on the concepts of policy intrusiveness and impact to ...


Combating Diabetes In Chittenden County: A Healthcare Provider Referral Campaign To Increase Patient Participation In The Vermont Diabetes Prevention Program, Samantha Magier 2017 Larner College of Medicine at The University of Vermont

Combating Diabetes In Chittenden County: A Healthcare Provider Referral Campaign To Increase Patient Participation In The Vermont Diabetes Prevention Program, Samantha Magier

Family Medicine Block Clerkship, Student Projects

As of 2016, diabetes affects more than 29 million people in the United States and is the 7th leading cause of death nationwide. In Vermont, 1/10 people are diagnosed with either diabetes or prediabetes, with 6% of Vermonters affected by prediabetes and 5% of Chittenden Country affected by prediabetes. The public health burden of this chronic disease is immense: diabetes costs Vermont an estimated $543 million each year and is the leading cause of kidney failure, lower limb amputations, and adult-onset blindness. Prediabetes occurs when blood sugar is higher than normal but not at the diagnostic threshold of diabetes ...


Amphetamine-Like Compounds In Pre-Workout Supplements, Andy Hsien Wei Koh 2017 Bond University

Amphetamine-Like Compounds In Pre-Workout Supplements, Andy Hsien Wei Koh

Theses

Pre-workout supplements (PWS), like most nutritional supplements, are classified by the Therapeutic Goods Administration (TGA) in Australia as complementary medicines and are therefore subject to much less stringent regulation compared to pharmaceuticals. Complementary medicines (also known as 'traditional' or 'alternative' medicines) include vitamin, mineral, herbal, aromatherapy and homoeopathic products. The overall goal of this thesis was to determine the amounts of stimulants in PWS, both the biogenic amines derived from Citrus aurantium (CA) extracts as well as caffeine and its dimethylxanthine (DMX) derivatives. Research questions have been put forward relating to the components within PWS and whether they comply with ...


Changes In Dietary Patterns And Body Composition Within 12 Months Of Liver Transplantation, McCoy Simone, Katrina Campbell, Annie-Claude Lassemillante, Matthew P. Wallen, Jonathan Fawcett, Maree Jarrett, Graeme A. Macdonald, Ingrid J. Hickman 2017 Princess Alexandra Hospital Brisbane

Changes In Dietary Patterns And Body Composition Within 12 Months Of Liver Transplantation, Mccoy Simone, Katrina Campbell, Annie-Claude Lassemillante, Matthew P. Wallen, Jonathan Fawcett, Maree Jarrett, Graeme A. Macdonald, Ingrid J. Hickman

Faculty of Health Sciences & Medicine Publications

Background:

Cardiometabolic risk factors are increasing in liver transplant recipients (LTR). Influencing dietary factors have not been assessed. The aim of this observational study was to assess changes in weight, metabolic function, dietary intake and eating behaviours in the first year after orthotopic liver transplantation (OLT).

Methods:

Consecutive recruitment of 17 patients (14 males) awaiting OLT at a single tertiary hospital. Dietary intake, food behaviours and anthropometry were recorded at baseline, and 6 and 12 months post-transplant.

Results:

By 12 months, patients had gained on average 7.3% of body weight. The prevalence of overweight or obesity increased from baseline ...


Oral Carbohydrate Administration Prior To Colorectal Surgery: Practice Change Outcomes And Economic Analysis, Joshua Kendrick Ezelle 2016 The University of Southern Mississippi

Oral Carbohydrate Administration Prior To Colorectal Surgery: Practice Change Outcomes And Economic Analysis, Joshua Kendrick Ezelle

Doctoral Nursing Capstone Projects

Difference in recovery times has been an interest of mine for many years. I observed that an open heart surgery routinely recovered and discharged on the third post-op day, while a colorectal patient often required a hospital stay of five to ten days. I began researching recovery methods of colorectal patients. I found enhanced recovery techniques like decreased narcotic, use of NSAID’s, early ambulation, and the use of medications that assist with bowel peristalsis are being employed nationally. Other techniques are now starting to be used with positive results. One of these is Carb-loading. Carb-loading is the oral intake ...


Current And Emerging Uses Of Statins In Clinical Therapeutics: A Review, Jonathan T. Davies, Spencer F. Delfino, Chad E. Feinberg, Meghan F. Johnson, Veronica L. Nappi, Joshua T. Olinger, Anthony P. Schwab, Hollie I. Swanson 2016 University of Kentucky

Current And Emerging Uses Of Statins In Clinical Therapeutics: A Review, Jonathan T. Davies, Spencer F. Delfino, Chad E. Feinberg, Meghan F. Johnson, Veronica L. Nappi, Joshua T. Olinger, Anthony P. Schwab, Hollie I. Swanson

Pharmacology and Nutritional Sciences Faculty Publications

Statins, a class of cholesterol-lowering medications that inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, are commonly administered to treat atherosclerotic cardiovascular disease. Statin use may expand considerably given its potential for treating an array of cholesterol-independent diseases. However, the lack of conclusive evidence supporting these emerging therapeutic uses of statins brings to the fore a number of unanswered questions including uncertainties regarding patient-to-patient variability in response to statins, the most appropriate statin to be used for the desired effect, and the efficacy of statins in treating cholesterol-independent diseases. In this review, the adverse effects, costs, and drug–drug and drug–food interactions associated ...


Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, MD, Thomas Melvin, Brandon Merritt, Charles Bishop, MD, Franklin D. Shuler, MD, PhD 2016 Marshall University, Joan C. Edwards School of Medicine

Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, Md, Thomas Melvin, Brandon Merritt, Charles Bishop, Md, Franklin D. Shuler, Md, Phd

Franklin D. Shuler

Vitamin K is known to play an essential role in the coagulation cascade; however, a growing body of research has found that a subtype of this vitamin, vitamin K2 (menaquinone) may have a beneficial effect in osteoporosis, cardiovascular disease, and cancer. This purpose of this article is to provide a comprehensive review of recent literature regarding menaquinone and its role in human health. This review discusses the physiology of menaquinone, its clinical benefits in cardiovascular disease, osteoporosis, and cancer, and how it may interact with certain medications. The authors conclude that menaquinone supplementation has been shown to improve carboxylation of ...


In Silico Investigation Into The Interactions Between Murine 5-Ht3 Receptor And The Principle Active Compounds Of Ginger (Zingiber Officinale)., Anna E. Lohning, Wolfgang Marx, Liz Isenring 2016 Bond University

In Silico Investigation Into The Interactions Between Murine 5-Ht3 Receptor And The Principle Active Compounds Of Ginger (Zingiber Officinale)., Anna E. Lohning, Wolfgang Marx, Liz Isenring

Faculty of Health Sciences & Medicine Publications

Gingerols and shogaols are the primary non-volatile actives within ginger (Zingiber officinale). These compounds have demonstrated in vitro to exert 5-HT3 receptor antagonism which could benefit chemotherapy-induced nausea and vomiting (CINV). The site and mechanism of action by which these compounds interact with the 5-HT3 receptor is not fully understood although research indicates they may bind to a currently unidentified allosteric binding site. Using in silico techniques, such as molecular docking and GRID analysis, we have characterized the recently available murine 5-HT3 receptor by identifying sites of strong interaction with particular functional groups at both the orthogonal (serotonin) site and ...


Malnutrition In The Older Australian Rural Rehabilitation Community : Indentification, Patient Outcomes And The Role Of Informal Caregivers, Skye Marshall 2016 Bond University

Malnutrition In The Older Australian Rural Rehabilitation Community : Indentification, Patient Outcomes And The Role Of Informal Caregivers, Skye Marshall

Skye Marshall

Enhancing the effectiveness of nutritional care to improve the overall health of older adults will be key in reducing hospital and aged care facility demand, a priority target of current health service research and policy. Engaging informal caregivers as part of the nutrition care team presents an opportunity for improving the nutrition status of older Australians in rehabilitation and the community. This thesis provides evidence to improve malnutrition screening, assessment, diagnosis and resource allocation in rehabilitation facilities. It also makes recommendations to improve nutrition intervention in practice, and for how intervention studies should be designed in this setting. The thesis ...


Process Evaluation Of A Patient-Centred, Patientdirected, Group-Based Education Program For The Management Of Type 2 Diabetes Mellitus, Kate Odgers-Jewell, Elisabeth Isenring, Rae Thomas, Dianne P Reidlinger 2016 Bond University

Process Evaluation Of A Patient-Centred, Patientdirected, Group-Based Education Program For The Management Of Type 2 Diabetes Mellitus, Kate Odgers-Jewell, Elisabeth Isenring, Rae Thomas, Dianne P Reidlinger

Faculty of Health Sciences & Medicine Publications

Aim:

The present study developed and evaluated a patient-centred, patient-directed, group-based education program for the management of type 2 diabetes mellitus.

Methods:

Two frameworks, the Medical Research Council (MRC) framework for developing and evaluating complex interventions and the RE-AIM framework were followed. Data to develop the intervention were sourced from scoping of the literature and formative evaluation. Program evaluation comprised analysis of primary recruitment of participants through general practitioners, baseline and end-point measures of anthropometry, four validated questionnaires, contemporaneous facilitator notes and telephone interviews with participants.

Results:

A total of 16 participants enrolled in the intervention. Post-intervention results were obtained ...


Tgf-Β Signaling: New Insights Into Aortic Aneurysms, Sean E. Thatcher 2016 University of Kentucky

Tgf-Β Signaling: New Insights Into Aortic Aneurysms, Sean E. Thatcher

Pharmacology and Nutritional Sciences Faculty Publications

No abstract provided.


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