The Role Of Nutrition In Promoting Gut Health And Treating Chronic Illness Through The Attenuation Of Inflammation, Allison Dalton
HCA Healthcare Journal of Medicine
Over the millennia, the human body and microorganisms such as bacteria, viruses, archaea, protozoa and parasites have coevolved together forming an intimate relationship. These microorganisms are found on the skin, in the mouth, genitourinary tract and most abundantly in the large intestine of the digestive tract. States of microbial dysbiosis contribute to chronic inflammation, which can lead to the pathogenesis and progression of numerous diseases. Micro- and macro-nutrients as well as dietary patterns like the Mediterranean diet can help improve health outcomes.
The Identification Of Long Non-Coding Rna Zfas1 Through An Exploratory Rna-Sequencing Analysis And Its Association With Epithelial-To-Mesenchymal Transition In Colon Cancer Adenocarcinoma., 2019 University of Louisville
The Identification Of Long Non-Coding Rna Zfas1 Through An Exploratory Rna-Sequencing Analysis And Its Association With Epithelial-To-Mesenchymal Transition In Colon Cancer Adenocarcinoma., Stephen J. O'Brien
Electronic Theses and Dissertations
Colorectal adenocarcinoma is the fourth most common cancer diagnosed worldwide and is a significant cause of morbidity and mortality. This dissertation performed an exploratory RNA-sequencing analysis comparing gene expression between colon adenocarcinoma tissue and paired normal colon epithelium. After identification of a number of lncRNAs that were increased in expression in colon adenocarcinoma compared to normal colon epithelium, we aimed to validate the expression and investigate their function in vitro. Specifically, we focused on the lncRNA ZFAS1 and its association with epithelial-to-mesenchymal transition. These studies found the following: 1. Seven candidate lncRNAs were identified from the exploratory RNA-sequencing analysis to ...
Using Shared Decision Making And Team-Based Care To Overcome Socioeconomic And Cultural Barriers To Colorectal Cancer Screenings, Amanda Powell, Debra Pyle, Kristin Rowse, Misty Weeman, Rachel Kidder, Internal Medicine/Pediatric Clinic, Ruth Hanselman, Suneela Nayak, Stephen Tyzik, Amy Sparks
Colorectal cancer is the third leading cause of cancer death in the United States. It disproportionally affects minorities and those in lower socioeconomic groups. The use of fecal immunochemical testing (FIT) is a low barrier, low cost and low risk screening tool as compared to the traditional colonoscopy exam. The use of FIT offers the opportunity to overcome barriers such as cultural, economic and low health literacy.
As part of a large health care system, an internal medicine clinic wanted to increase the use and return of FIT in their clinic patients. A team developed a plan for implementing improvement ...
A Provider-Driven Approach To Preventative Oral Care In Nursing Home Facilities, 2019 Maine Medical Center
A Provider-Driven Approach To Preventative Oral Care In Nursing Home Facilities, Molly Anderson, Brandon Mccrossin, Kary Franchetti, Ruth Hanselman, Suneela Nayak, Stephen Tyzik, Amy Sparks
Oral care is an essential part of preventative medicine as it minimizes risk for pneumonias and other infections. In nursing home settings, often oral health care is not routinely provided due to a number of issues. A health care system that either owns or contracts nursing home facilities initiated a performance improvement plan to address this patient care concern.
The first goal of this project was to reduce the variation in oral care between nursing home facilities within the system. The second goal was 100% of their patients will have one oral health care exam documented in EPIC once a ...
Assessment Of Physical Fitness After Bariatric Surgery And Its Association With Protein Intake And Type Of Cholecalciferol Supplementation, 2019 Catharina Hospital (Netherlands)
Assessment Of Physical Fitness After Bariatric Surgery And Its Association With Protein Intake And Type Of Cholecalciferol Supplementation, Hendrika J M Smelt, Sjaak Pouwels, Alper Celik, Adarsh Gupta, Johannes F Smulders
School of Osteopathic Medicine Faculty Scholarship
Background: Several studies showed that there is a relationship between vitamin and mineral status and muscle strength. In particular this is the case for handgrip strength (HS) and vitamin D deficiency. In bariatric surgery there is a risk of decrease in muscle strength after surgery and also vitamin and mineral deficiencies are not uncommon. The aim of this study is to assess the effect of low vitamin 25 (OH) cholecalciferol levels, high dose cholecalciferol supplementation regime and protein intake on physical fitness, measured using handgrip strength (HS) and the shuttle walk run test (SWRT). Methods: For this retrospective study, 100 ...
A Rare Manifestation Of A Bleeding Tubulovillous Duodenal Polyp Presenting As An Upper Gastrointestinal Hemorrhage, Neethi Dasu, Yaser Khalid, Herman Suga, Michael Itidiare, Richard Walters
Stratford Campus Research Day
• Duodenal polyps are a group of polyps that are fairly uncommon to find on endoscopic evaluation (1).
• They are histologically classified according to mucin phenotype into intestinal and gastric subtypes; the intestinal-type polyps are morphologically subdivided into tubular and tubulovillous adenomas (2)
• We present a case of a 76-year-old male with recurrent hematemesis who was found to have an intestinal-type pedunculated tubulovillous adenoma (TVA) in the descending duodenum • An isolated occurrence of non-ampullary sporadic duodenal adenomas (SDA)’s are a rare finding and presentation as an upper GI hemorrhage is extremely uncommon (3)
• Furthermore, our patient’s polyp was pedunculated ...
Xerostomia: A Comprehensive Review, 2019 Wayne State University
Xerostomia: A Comprehensive Review, Danevin Putrus
Honors College Theses
This thesis will be highlighting the condition known as Xerostomia. Xerostomia is the condition also known as “dry mouth”. This condition affects many people all throughout the world with symptoms causing bad breath, discomfort, difficulty speaking and many other. The seriousness of this condition can lead to cardiovascular disease, dementia, respiratory infections, diabetes mellitus, rheumatoid arthritis, and even cancer (Absolutedental.com). Currently there is not any one specific solution for the condition although many have been proposed. Throughout the thesis I will closely examine former research studies, current solutions proposed, and propose my own study and solution based on research ...
Microbiota Signatures In Type-2 Diabetic Patients With Chronic Kidney Disease - A Pilot Study, 2019 The Research Institute of the University of Bucharest (ICUB), Bucharest, Romania
Microbiota Signatures In Type-2 Diabetic Patients With Chronic Kidney Disease - A Pilot Study, Gratiela P. Gradisteanu, Roxana A. Stoica, Laura Petcu, Ariana Picu, Adrian P. Suceveanu, Teodor Salmen, Diana S. Stefan, Cristian Serafinceanu, Mariana Carmen Chifiriuc, Anca P. Stoian
Journal of Mind and Medical Sciences
The human microbiota is paramount for normal host physiology. Altered host-microbiome interactions are part of the pathogenesis of numerous common ailments. Currently, much emphasis is placed on the involvement of the microbiome in the pathogenesis of type-2 diabetes mellitus (T2DM), impaired glucose tolerance, and other metabolic disorders (i.e. obesity). Several studies found highly significant correlations of specific intestinal bacteria with T2DM. A better understanding of the role of the microbiome in diabetes and its complications might provide new insights in the development of new therapeutic principles.
Our pilot study investigates the microbiota patterns in Romanian type-2 diabetic patients with ...
Photodynamic Therapy As A New Therapeutic Approach Of Oral Lichen Planus, 2019 Wolfson Medical Center, 61 Halochamim Street, 58100, Holon, Israel
Photodynamic Therapy As A New Therapeutic Approach Of Oral Lichen Planus, Sandra Milena Tocut, Madalina Irina Mitran, Cristina Iulia Mitran, Mircea Tampa, Maria Isabela Sarbu, Gabriela Loredana Popa, Simona Roxana Georgescu
Journal of Mind and Medical Sciences
Oral lichen planus (OLP) is a chronic, immunologically mediated disease, defined by periods of exacerbation and quiescence. The disease is associated with a low mortality risk, but in some instances, morbidity can be important, especially in extensive, erosive forms, with a significant impact on the quality of life. OLP is a chronic T-cell mediated inflammatory disease involving the oral cavity, the most common lesions being located on the oral mucosa, tongue and gums. Its etiology remains in part unknown, but several factors proved to be involved in the development of the disease (drugs, dental materials, infectious agents, psychological factors, autoimmunity ...
The Pharmabiotic For Phenylketonuria: Development Of A Novel Therapeutic, 2019 University of South Carolina
The Pharmabiotic For Phenylketonuria: Development Of A Novel Therapeutic, Chloé Elizabeth Lebegue
Phenylketonuria, now known as phenylalanine hydroxylase (PAH) deficiency, is a genetic disorder of metabolism affecting approximately one in every 15,000 infants born in the United States. Patients have nonfunctional PAH enzyme secondary to one or more genetic mutations. The enzyme deficit results in destructive supraphysiologic blood phenylalanine levels upon consumption of the essential dietary amino acid phenylalanine. Current standards of care mitigate signs and symptoms of the disorder, but do not approach a cure. The methods for creating a prototype pharmabiotic as an innovative treatment strategy for PAH deficiency are described herein.
DNA molecular cloning techniques were utilized to ...
Naktide Targeted To Adipocytes Ameliorates Western Diet Induced Obesity, 2019 Marshall University
Naktide Targeted To Adipocytes Ameliorates Western Diet Induced Obesity, Rebecca D. Pratt
Theses, Dissertations and Capstones
Obesity has become a worldwide epidemic and is a major risk factor for metabolic syndrome. It is believed that cellular oxidant stress plays a key role in both the development and maintenance of obesity as well as its associated comorbidities such as diabetes, cardiovascular disease, and nonalcoholic steatohepatitis (NASH). We have previously reported that systemic administration of pNaKtide, which targets the Na/K-ATPase oxidant amplification loop was able to decrease oxidative stress and adiposity in mice fed a high fat and fructose supplemented western diet (WD). As adipocytes are believed to play an active role in the development of obesity ...
Development Of Qpcr Based Method To Quantify Colonization Of An Engineered Bacterium In Gut, 2019 Iowa State University
Development Of Qpcr Based Method To Quantify Colonization Of An Engineered Bacterium In Gut, Alexandra (Alex) Mcmullen
Parkinson’s Disease is the leading neurodegenerative disease in the western world, caused by degeneration of neurons in the substantia nigra. This causes a decrease of dopamine in nigrostriatal neural circuitry, leading to motor and nonmotor symptoms which can be incredibly debilitating for the patient. Current dopamine supplementation therapy does not provide a steady state neurotransmitter level and can lead to dyskinesias and dystonia’s. However, Escherichia coli Nissle (EcN) bacteria have been shown to prove effective therapeutic treatments that can be engineered to specifically treat certain diseases, such as Phenylketonuria. EcN can be engineered to upregulate production of L-DOPA ...
Session 3 Discussion: The Microstructure Of Eating, 2018 Purdue University
Session 3 Discussion: The Microstructure Of Eating, Cordelia Running, Bryony James, James Hollis, Kelly Higgins
Food Science and Human Nutrition Publications
The Microstructure of Eating.
Dietary Habits And Lifestyle In School-Aged Children From Bucharest, Romania, 2018 Carol Davila University of Medicine and Pharmacy, Department of Diabetes, Nutrition and Metabolic Disease
Dietary Habits And Lifestyle In School-Aged Children From Bucharest, Romania, Anca Pantea Stoian, Liliana F. Andronache, Razvan Hainarosie, Dan N. Paduraru, Cristinel D. Badiu, Andreea Arsene, Claudia Mehedintu, Georgiana Ditu, Silviu M. Pituru, Cristina Orlov, Mihaela Oros, Cornelia Nitipir
Journal of Mind and Medical Sciences
Background. This study evaluated the difference between boys and girls in terms of nutritional status, lifestyle, and dietary habits during school life.
Materials and Methods. A descriptive and observational study was conducted in 2016, in which 251 children, aged 7-17, from 3 elementary schools and a high school inBucharest,Romania, were evaluated. A questionnaire was used to assess food behavior, eating, and lifestyle habits.
Results. Boys had a significantly higher waist circumference (71.18±9) than girls (67.46±9.91) (p=0.004). Thus 27% of boys were overweight or obese compared with only 22% of the girls. Differences ...
Development Of A Self-Care Questionnaire For Clinical Assessment Of Self-Care In Patients With Inflammatory Bowel Disease: A Psychometric Evaluation, Loven Wickman, Henrik Hjortswang, Marika Wenemark, Henrik Stjernman, Gunilla H. Frisman, Barbara Riegel, Pia Yngman-Uhlin
School of Nursing Departmental Papers
Background: Patients with inflammatory bowel disease have lifelong needs to learn how to manage their symptoms and life situation. The range of actions that patients take in order to manage daily life and maintain health is referred to as self-care. Assessment of self-care inpatients with inflammatory bowel disease could allow targeted support and education by health care professionals.There are no existing measures assessing self-care in patients with inflammatory bowel disease.
Objectives: The aim was to develop and evaluate the self-care questionnaire for assessment of self-care among patients with inflammatory bowel disease.
Methods: Qualitative and quantitative methods were used to ...
A Gut Feeling: A Hypothesis Of The Role Of The Microbiome In Attention-Deficit/Hyperactivity Disorders., 2018 Rutgers University - Newark
A Gut Feeling: A Hypothesis Of The Role Of The Microbiome In Attention-Deficit/Hyperactivity Disorders., Xue Ming, Neil Chen, Carly Ray, Gretchen Brewer, Jeffrey Kornitzer, Robert A Steer
School of Osteopathic Medicine Faculty Scholarship
Attention-deficit/hyperactivity disorder (ADHD) is a neurologic disorder characterized by hyperactivity/impulsivity and/or inattentiveness, with genetic and environmental factors contributing to the disorder. With the growing recognition of the microbiome's role in many neurological disorders, the authors propose that it may also be implicated in ADHD. Here, we describe several evolving areas of research to support this hypothesis. First, a unique composition of gut bacteria has been identified and linked to behaviors in ADHD. Second, our research found an increased incidence of 2 gastrointestinal symptoms (constipation and flatulence) in children with ADHD, as compared to controls. Finally, emerging ...
Understanding The Role Of Phosphoinositide 3-Kinase And Its Function As A Driving Force Behind The Er Stress Response In Fibrostenotic Crohn’S Disease-Affected Ileal Smooth Muscle Cells, 2018 Virginia Commonwealth University
Understanding The Role Of Phosphoinositide 3-Kinase And Its Function As A Driving Force Behind The Er Stress Response In Fibrostenotic Crohn’S Disease-Affected Ileal Smooth Muscle Cells, Prashant Yadav
Theses and Dissertations
Crohn’s disease (CD) affects about 780,000 people in the United States alone, and it is estimated that 6-15 per 100,000 persons will receive a diagnosis of this disease each year. There currently is no cure for Crohn’s disease, and available medical therapies simply serve to alleviate the inflammation. This does not help treat fibrostenosis that Crohn’s disease patients may develop, which can only be treated surgically. Finding alternatives to treat CD requires an understanding of mechanisms at the biochemical level. In this thesis, we attempted to gain a better understanding of certain pathways found to ...
Problems In Embalming: Cyanide Poisoning, 2017 Southern Illinois University Carbondale
Problems In Embalming: Cyanide Poisoning, Rebecca Majus
ASA Multidisciplinary Research Symposium
To inform funeral professionals, or anyone interested, what cyanide poisoning is, how death from it occurs, how to detect it in postmortem remains, how it poses a problem for embalmers, and what embalming techniques can be used to treat it.
Numerical Simulation Of Heat Stress In Chemical Protective Clothing, 2017 Donghua University
Numerical Simulation Of Heat Stress In Chemical Protective Clothing, Jie Yang, Guowen Song, Liwen Wang, Yun Su, Chunhui Xiang
Apparel, Events and Hospitality Management Publications
The aim of the paper is to predict heat stress of human wearing chemical protective clothing (CPC). A proposed human thermal model was applied to simulate the core and skin temperatures with inputs of human activity level, clothing properties, and environmental conditions. Manikin tests were conducted to measure the thermal insulation and evaporative resistance of clothing which were two important inputs of the thermal model. The core temperature was predicted as an indicator of heat stress to evaluate the maximum exposure time. The effects of ambient temperature, relative humidity, and metabolic rate on core temperature, skin temperature, and maximum exposure ...
Herpes Simplex Proctitis Mimicking Inflammatory Bowel Disease In A Teenaged Male, 2017 University of Iowa
Herpes Simplex Proctitis Mimicking Inflammatory Bowel Disease In A Teenaged Male, Kristen E Sandgren, Nathan B Price, Warren P Bishop, Patrick J Mccarthy
Stead Family Department of Pediatrics Publications
We report the case of a 17-year-old male who was initially assessed for pain with defecation, bloody rectal discharge, and diarrhea, consistent with proctitis. Though proctitis is most commonly due to inflammatory bowel disease (IBD), infectious etiologies must also be considered, including sexually transmitted causes of infectious proctitis. In discussion of his sexual history, he identified as homosexual and acknowledged engaging in receptive anal intercourse. Rectal biopsies obtained via colonoscopy were culture-positive for herpes simplex virus (HSV), leading to a diagnosis of HSV proctitis and treatment with an appropriate antiviral medication. HSV proctitis is more common in individuals with high-risk ...