Digestive, Oral, and Skin Physiology Commons

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Recent Articles in Digestive, Oral, and Skin Physiology

Celiac Disease And Neurological Symptoms, Lauren V. Cook Liberty University

Celiac Disease And Neurological Symptoms, Lauren V. Cook

Senior Honors Papers

New research has revealed that Celiac disease, an autoimmune illness affecting the small intestine, has more ties with neurological side effects than once was thought. The classic and most well known presentation of Celiac disease is gastrointestinal, including symptoms such as abdominal pains, nausea, diarrhea, and flatulence. Researchers have more recently found a correlation between Celiac disease and neurological illnesses such as epilepsy, depression, dementia, and ADHD. Physician awareness of the disease and the neurological side of the illness should be heightened in order for patients to receive earlier diagnosis and a better quality of life. Because of the difficulty ...


Gastrointestinal-Sparing Effects Of Novel Nsaids In Rats With Compromised Mucosal Defence, Rory W. Blackler McMaster University

Gastrointestinal-Sparing Effects Of Novel Nsaids In Rats With Compromised Mucosal Defence, Rory W. Blackler

Open Access Dissertations and Theses

Nonsteroidal anti-inflammatory drugs are among the most commonly used prescription and over-the-counter medications, but they often produce significant gastrointestinal ulceration and bleeding, particularly in elderly patients and patients with certain co-morbidities. Novel anti-inflammatory drugs are seldom tested in animal models that mimic the high-risk human users, leading to an underestimate of the true toxicity of these drugs. In the present study we examined the effects of two novel NSAIDs and two commonly used NSAIDs in models in which mucosal defence was expected to be impaired. Naproxen, celecoxib, ATB-346 (a hydrogen sulfide- and naproxen-releasing compound) and NCX 429 (a nitric oxide- ...


Mechanisms Underlying Rhythmic Activities Of The Gastrointestinal Tract, Marc J. Pistilli McMaster University

Mechanisms Underlying Rhythmic Activities Of The Gastrointestinal Tract, Marc J. Pistilli

Open Access Dissertations and Theses

The organs of the gastrointestinal (GI) tract display a variety of motor patterns, involved in grinding, mixing, enhancing absorption and propulsion of nutrients and waste products. Specialized motor patterns are generated by unique mechanisms inherent to the GI segment in which they are found. Rhythmic contractions are a feature of most motor patterns. Slow wave driven peristalsis is an acknowledged motor pattern associated with interstitial cells of Cajal (ICC) pacemakers, but propulsive motor patterns which are blocked by tetrodotoxin are seen to be exclusively generated by the enteric nervous system (ENS). This has not been proven, however, and the origin ...


The Role Of Tim-4 In The Intestinal Inflammation, Natasha Nurtanio McMaster University

The Role Of Tim-4 In The Intestinal Inflammation, Natasha Nurtanio

Open Access Dissertations and Theses

Inflammatory Bowel Disease (IBD) is a chronic intestinal inflammation that has caused many challenges for healthcare providers in treating the disease and also altered the quality of life of the patients. The cure for IBD is still symptomatic-based; the causes mechanism and pathogenesis of IBD are to be further investigated. Currently, IBD has been considered as an excessive immune response to commensal flora that in normal condition is tolerable to the host. Antigen presenting cells (APCs) play an important role in the pathogenesis of IBD. Macrophage is one of the professional APCs that present antigen information to T cells and ...