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Local Anesthesia Toxicity, Nicole McCleery 2017 Otterbein University

Local Anesthesia Toxicity, Nicole Mccleery

Master of Science in Nursing (MSN) Student Scholarship

Local anesthesia (LA) provides a way to relieve temporary pain in a small part of the body and has been used for over 100 years (Fencl, 2015). LA also prevents the passage of surgical stimuli into the central nervous system (CNS) making a surgical procedure less painful for the patient (Noble, 2015). According to Noble, “altering the passage of stimuli from smaller diameter neurons in a confined area with lower drug dosages is called LA, such as the injection of LA around a surgical incision” (Noble, 2015, p.325). LA can be used in a variety of settings, such as ...


Diagnostic Effectiveness Of High-Sensitivity Troponins, Sean R. Bodin, Jacqueline Ramirez 2017 James Madison University

Diagnostic Effectiveness Of High-Sensitivity Troponins, Sean R. Bodin, Jacqueline Ramirez

Physician Assistant Capstones

Background: Acute myocardial infarctions (AMI) are a leading cause of death in the United States. The key to increasing survivability is early recognition to expedite the proper treatment modalities. In conjunction with the clinical presentation and electrocardiograms, the use of cardiac biomarkers is exponentially important in not only recognizing a cardiac event but also determining the extent of injury. Advancement in laboratory technology has led to the development of high-sensitive troponin (hs-troponin) assays which can detect smaller cardiac troponin serum levels compared to conventional troponin assays. This implies that the use of hs-troponin assays is more effective in the early ...


Humor In Medicine: A Literature Review Of Humor’S Potential Therapeutic Value In Health Care, Weston Michael Grant 2017 University of Arkansas

Humor In Medicine: A Literature Review Of Humor’S Potential Therapeutic Value In Health Care, Weston Michael Grant

Psychological Science Undergraduate Honors Theses

Using humor and laughter within the health care field has the potential to be relevant to patients during treatment, to the patient-caregiver relationship, to the subjective well-being of health care providers, and to the environments’ (e.g., work settings) impact on group relationships (e.g., colleagues). A review of the literature examines how the psychological and physiological effects of laughter and humor within the human body impact health and well-being, how humor and laughter improve the patient-practitioner relationship, and if humor and laughter can potentially impact physician burnout. Several possible implications for these findings are discussed, such as professional medical ...


The Science Of Singing: A Voice Lesson From Anatomy And Physiology, Gracie Bennett 2017 Cedarville University

The Science Of Singing: A Voice Lesson From Anatomy And Physiology, Gracie Bennett

The Research and Scholarship Symposium

The voice is the oldest instrument in existence. Throughout its history, there have been many vocal performances practices. The purpose of my research is to show the correlation between modern vocal practices and the current medical technology available to help us understand the physiology of the voice. I am studying and analyzing the vocal performance and pedagogical practices from the early church to present day. I want to know why these vocal strategies have changed over time. There have been several different schools of thinking in regards to vocal practices. From the Italian style bel canto singing that was widely ...


Motor Axon Synapses On Renshaw Cells Contain Higher Levels Of Aspartate Than Glutamate, Dannette Shanon Richards, Ronald W. Griffith, Shannon H. Romer, Francisco J. Alvarez 2017 Wright State University

Motor Axon Synapses On Renshaw Cells Contain Higher Levels Of Aspartate Than Glutamate, Dannette Shanon Richards, Ronald W. Griffith, Shannon H. Romer, Francisco J. Alvarez

Francisco J. Alvarez

Motoneuron synapses on spinal cord interneurons known as Renshaw cells activate nicotinic, AMPA and NMDA receptors consistent with co-release of acetylcholine and excitatory amino acids (EAA). However, whether these synapses express vesicular glutamate transporters (VGLUTs) capable of accumulating glutamate into synaptic vesicles is controversial. An alternative possibility is that these synapses release other EAAs, like aspartate, not dependent on VGLUTs. To clarify the exact EAA concentrated at motor axon synapses we performed a quantitative postembedding colloidal gold immunoelectron analysis for aspartate and glutamate on motor axon synapses (identified by immunoreactivity to the vesicular acetylcholine transporter; VAChT) contacting calbindin-immunoreactive (-IR) Renshaw ...


Using Heart Models For Physiology Teaching And Learning, Sowmya Anjur 2017 Illinois Mathematics and Science Academy

Using Heart Models For Physiology Teaching And Learning, Sowmya Anjur

Sowmya Anjur

Over the last few decades, there has been a shift in the classroom from a teacher-centered learning environment, with its emphasis on content delivery, to a student-centered environment focused on inquiry learning (http://www.nsta.org/docs/ PositionStatement_Scienti cInquiry.pdf). With the Next Generation Science Standards (NGSS, 2012) being adopted by many states, students are no longer passive listeners, but actively participate in and initiate class discussions (Weimar, 2013). Additionally, recent technological advances have allowed students to acquire information from sources such as the internet which no longer necessitates the teacher giving lectures (Silver- thorn, 2006). The more student-centered learning ...


Analysis Of Proprioceptive Sensory Innervation Of The Mouse Soleus: A Whole-Mount Muscle Approach, Martha Jean Sonner, Marie C. Walters, David R. Ladle 2017 Wright State University

Analysis Of Proprioceptive Sensory Innervation Of The Mouse Soleus: A Whole-Mount Muscle Approach, Martha Jean Sonner, Marie C. Walters, David R. Ladle

Neuroscience, Cell Biology & Physiology Faculty Publications

Muscle proprioceptive afferents provide feedback critical for successful execution of motor tasks via specialized mechanoreceptors housed within skeletal muscles: muscle spindles, supplied by group Ia and group II afferents, and Golgi tendon organs, supplied by group Ib afferents. The morphology of these proprioceptors and their associated afferents has been studied extensively in the cat soleus, and to a lesser degree, in the rat; however, quantitative analyses of proprioceptive innervation in the mouse soleus are comparatively limited. The present study employed genetically-encoded fluorescent reporting systems to label and analyze muscle spindles, Golgi tendon organs, and the proprioceptive sensory neuron subpopulations supplying ...


Biomarkers Of Sepsis: A Retrospective Approach, Jose M. Roberts 2017 The University of Akron

Biomarkers Of Sepsis: A Retrospective Approach, Jose M. Roberts

Honors Research Projects

Background: Biomarkers are taking the spotlight in becoming the norm for early diagnoses. Sepsis is an inflammatory disease that increases metabolic rate in children. The first biomarker is hyponatremia. Hyponatremia is a frequent electrolyte imbalance in clinical practice, often observed in children with inflammatory disease and infection. Presence of hyponatremia is associated with electrical signaling imbalances, inflammation and renal dysfunction. The clinical value of hyponatremia in pediatric patients is unknown. The C-reactive protein is a second biomarker. Its presence signifies that necrotic cells and inflammation are present.

Objectives: To evaluate the use of biomarkers in children seen in the Emergency ...


Dynamics Of Mitotic Microtubules In Fission Yeast, Patrick Flynn 2017 University of Colorado, Boulder

Dynamics Of Mitotic Microtubules In Fission Yeast, Patrick Flynn

Undergraduate Honors Theses

Microtubules (MTs) are cytoskeletal polymers that assemble into a biomechanical complex known as the mitotic spindle. The spindle is responsible for the equal partitioning of chromosomes during cell division; an event known as mitosis. The dependence of proper chromosome segregation on the dynamics of individual microtubules (MTs) is not well understood or easy to study due to their small size and quick dynamics. Mathematical models and simulations have been constructed in order to better understand the physical basis of how the mitotic spindle accurately, or inaccurately, divides duplicated chromosomes during mitosis. These models rely on the dynamics parameters of individual ...


Neuroinflammation In Alzheimer's Disease And Vascular Cognitive Impairment, Erica M. Weekman 2017 University of Kentucky

Neuroinflammation In Alzheimer's Disease And Vascular Cognitive Impairment, Erica M. Weekman

Theses and Dissertations--Physiology

It was once believed that the brain was immunologically privileged with no resident or infiltrating immune cells; however, now it is understood that the cells of the brain are capable of a wide range of inflammatory processes and phenotypes. Inflammation in the brain has been implicated in several disease processes such as Alzheimer’s disease (AD) and vascular cognitive impairment and dementia (VCID); however, the role of inflammation in these two dementias is poorly understood.

When we stimulated a pro-inflammatory phenotype with an adeno-associated viral vector in a transgenic mouse model of AD that develops Aβ plaques, we saw a ...


The Effects Of Exercise Preconditioning On Focal Ischemic Stroke, Gillian Grohs 2017 University of Kentucky

The Effects Of Exercise Preconditioning On Focal Ischemic Stroke, Gillian Grohs

Theses and Dissertations--Medical Sciences

Cleaved fragments of the extracellular matrix protein perlecan have been shown to promote neuroprotection and repair after ischemic stroke. The cysteine proteases cathepsin B and L as well as the metalloprotease bone morphogenic protein 1 (BMP-1) are capable of releasing the biologically active C-terminal laminin-like globular domain (LG3) of perlecan. Exercise, a known method of reducing stroke risk and severity, has been shown to increase the expression of some proteases associated with perlecan processing. Using a transient distal middle cerebral artery occlusion (MCAo) model for focal ischemic stroke we show that while 7 days of running only slightly decreased infarct ...


Signaling Components Involved In The Hormone Induced Translocation Of Enac In Cultured Adult Human Fungiform (Hbo) Taste Cells, Deanna Hojati 2017 Virginia Commonwealth University

Signaling Components Involved In The Hormone Induced Translocation Of Enac In Cultured Adult Human Fungiform (Hbo) Taste Cells, Deanna Hojati

Theses and Dissertations

The amiloride-sensitive epithelial Na+ channel, ENaC, is the Na+-specific salt taste receptor in rodents. Compared to rodents, human salt taste perception is amiloride-insensitive. In rodents the ENaC is composed of aβg-subunits. Whereas humans express an additional subunit, the d-ENaC subunit. ENaC in human taste cells is composed of aβg-subunits or dβg-subunits, with the latter being amiloride-insensitive. Currently, it is not known if dβg-ENaC expression and trafficking is regulated by hormones and their downstream intracellular signaling effectors. The aim of this study is to investigate if arginine vasopressin (AVP), aldosterone, and cAMP regulate d-ENaC expression and trafficking in cultured fungiform ...


The [E]Motionless Body No Longer: Tracing The Historical Intersections Of Mental Illness And Movement In The American Asylum, Holly Adele Herzfeld 2017 Bard College

The [E]Motionless Body No Longer: Tracing The Historical Intersections Of Mental Illness And Movement In The American Asylum, Holly Adele Herzfeld

Senior Projects Spring 2017

Senior Project submitted to The Division of Multidisciplinary Studies of Bard College.


Effects Of Neonatal Supplemental Oxygen And High Fat Diet On Weight Gain, Ventricular Hypertrophy And Contractility, Shreya Chandrasekar, Melissa L. Bates, Shilpa Vellookunnel, Michael J. Hoover, Madison E. Sturgeon, Austin Murphy 2017 University of Iowa

Effects Of Neonatal Supplemental Oxygen And High Fat Diet On Weight Gain, Ventricular Hypertrophy And Contractility, Shreya Chandrasekar, Melissa L. Bates, Shilpa Vellookunnel, Michael J. Hoover, Madison E. Sturgeon, Austin Murphy

University of Iowa Honors Theses

Premature birth represents about 13% of live births each year. Since lungs of these infants are underdeveloped, they receive supplemental oxygen right after birth, but little is known about its effects on the development of normal physiological responses and whether it impacts long-term cardio-metabolic function. Based on previous studies from our lab that showed increased pulse wave velocity in 12 month old rats exposed to neonatal supplemental oxygen, we hypothesized that neonatal exposure to supplemental oxygen causes cardiac hypertrophy and decreased left ventricular contractility. We also hypothesized that these effects to supplemental oxygen would be enhanced by 10 weeks on ...


Perceptual Variations In Thermoregulation During Exercise In A Hot Environment, William C. Alger 2016 Stephen F Austin State University

Perceptual Variations In Thermoregulation During Exercise In A Hot Environment, William C. Alger

Electronic Theses and Dissertations

ABSTRACT

Professionals are seeking to find ways to prevent exertional heat illness (EHI) in populations working in hot environments as well as populations that are physically active. The purpose of the present study was to evaluate individuals’ ability to accurately perceive core temperature ranges associated with homeothermic and EHI temperatures during exercise. Ten physically active males exercised on a treadmill at a self-selected rate until core temperature reached 39°C. Participants rated perceived core and skin temperature on 100 mm scales each time core temperature increased 0.25˚ C (37.5-39.0˚ C), along with thermal comfort and sweating sensation ...


The Effects Of Direct Peritoneal Resuscitation On Leukocyte Infiltration After Acute Brain Death., Jessica Lee Weaver 2016 University of Louisville

The Effects Of Direct Peritoneal Resuscitation On Leukocyte Infiltration After Acute Brain Death., Jessica Lee Weaver

Electronic Theses and Dissertations

Background: Brain death triggers an inflammatory response that is associated with worse outcomes for recipients of transplanted organs procured from brain dead donors. The intestine has been shown to release inflammatory mediators in other types of shock, but its role is brain death is not well described. Direct peritoneal resuscitation (DPR) improves visceral organ blood flow and has been shown to reduce inflammation after hemorrhagic shock. Better understanding of this inflammatory process within the peripheral organs, the effects of DPR, and the role of the intestine could aid in better resuscitation of potential organ donors. Methods: Male Sprague-Dawley rats were ...


Seniors Welcome! Avoiding The Trap Of Age Limits In Health Research, Arshad Jahangir 2016 Sheikh Khalifa bin Hamad Al Thani Center for Integrative Research on Cardiovascular Aging, Aurora Research Institute

Seniors Welcome! Avoiding The Trap Of Age Limits In Health Research, Arshad Jahangir

Journal of Patient-Centered Research and Reviews

The guest editor introduces this specialty issue of the Journal of Patient-Centered Research and Reviews, which focuses on cardiovascular diseases in the elderly. The reality of an aging population has increased the need for better evidence-based medicine in older patients. However, randomized controlled trials frequently exclude such patients, especially those with comorbidities, from study. This practice ignores the fact that physiologic changes to the cardiovascular system caused by the aging process and aging-associated diseases create clinical dilemmas distinct from those in younger patients. Considering the rising costs of health care and growing incidence of cardiovascular disease, research efforts and resources ...


Effects Of Auditory Vection Speed And Directional Congruence On Perceptions Of Visual Vection, Isabella Alexis Gagliano 2016 Old Dominion University

Effects Of Auditory Vection Speed And Directional Congruence On Perceptions Of Visual Vection, Isabella Alexis Gagliano

Psychology Theses & Dissertations

Spatial disorientation is a major contributor to aircraft mishaps. One potential contributing factor is vection, an illusion of self-motion. Although vection is commonly thought of as a visual illusion, it can also be produced through audition. The purpose of the current experiment was to explore interactions between conflicting visual and auditory vection cues, specifically with regard to the speed and direction of rotation. The ultimate goal was to explore the extent to which aural vection could diminish or enhance the perception of visual vection. The study used a 3 × 2 within-groups factorial design. Participants were exposed to three levels of ...


The Substrate Of The Biopsychosocial Influences In The Carcinogenesis Of The Digestive Tract, Georgică C. Târtea, Cristina Florescu, Daniel Pirici, Daniel Caragea, Elena A. Târtea, Cristin C. Vere 2016 Cardiology Resident Doctor, PhD Student Internal Medicine, University of Medicine and Pharmacy of Craiova, Romania

The Substrate Of The Biopsychosocial Influences In The Carcinogenesis Of The Digestive Tract, Georgică C. Târtea, Cristina Florescu, Daniel Pirici, Daniel Caragea, Elena A. Târtea, Cristin C. Vere

Journal of Mind and Medical Sciences

Digestive cancer represents a severe public health problem, being one of the main causes of death. It is considered a multifactorial disease, with hereditary predisposition, environmental factors, and other factors involved in carcinogenesis. Both the evolution and the pathogenesis of digestive neoplasms remain incompletely elucidated. As a multifactorial disease, it can be approached by taking into account the biopsychosocial influences via enteric nervous system. Many peptides and non-peptides having a neurotransmitter role can be found in the enteric nervous system, which can influence the neoplastic process directly or indirectly by affecting some angiogenic, growth, and metastasis factors. However, neurotransmitters can ...


A Note Regarding The Mathematical Treatment Of A Class Of Steady-State Compartmental Models Of The Circulation, Ronald White 2016 Montana Tech of the University of Montana

A Note Regarding The Mathematical Treatment Of A Class Of Steady-State Compartmental Models Of The Circulation, Ronald White

Center for Advanced Mineral and Metallurgical Processing (CAMP)

A class of steady-state compartmental models of the circulation is examined and it is shown that the mathematical problem for this model class involves a single nonlinear equation. In an important subclass and with certain assumptions regarding the form of the Starling-type cardiac function curves, the single equation is of the form Z = μ + λ log[(1 − Z)/Z] where μ and λ are mathematical parameters related to the physiological parameters of the system and Z is proportional to the cardiac output. This result holds regardless of the number and arrangement of compartments within the model itself or of the ...


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