Liberty University
University of Pennsylvania
University of North Texas Health Science Center
University of Central Florida
Marshall University
University of Dayton
National Research Center, Egypt
East Tennessee State University
Early Protein Intake Predicts Functional Connectivity And Neurocognition In Preterm Born Children,
2021
The University of Western Ontario
Early Protein Intake Predicts Functional Connectivity And Neurocognition In Preterm Born Children, Emma G. Duerden, Benjamin Thompson, Tanya Poppe, Jane Alsweiler, Greg Gamble, Yannan Jiang, Myra Leung, Anna C. Tottman, Trecia Wouldes, Steven P. Miller, Jane E. Harding, Jane M. Alsweiler, Janene B. Biggs, Coila Bevan, Joanna M. Black, Frank H. Bloomfield, Kelly Fredell, Greg D. Gamble, Jane E. Harding, Sabine Huth, Yannan Jiang, Christine Kevan, Myra Leung, Geraint Phillips, Tanya Poppe, Jennifer A. Rogers, Heather Stewart, Benjamin S. Thompson
Brain and Mind Institute Researchers' Publications
© 2021, The Author(s). Nutritional intake can promote early neonatal brain development in very preterm born neonates (< 32 weeks’ gestation). In a group of 7-year-old very preterm born children followed since birth, we examined whether early nutrient intake in the first weeks of life would be associated with long-term brain function and neurocognitive skills at school age. Children underwent resting-state functional MRI (fMRI), intelligence testing (Wechsler Intelligence Scale for Children, 5th Ed) and visual-motor processing (Beery-Buktenica, 5th Ed) at 7 years. Relationships were assessed between neonatal macronutrient intakes, functional connectivity strength between thalamic and default mode networks (DMN), and neuro-cognitive function using multivariable regression. Greater functional connectivity strength between thalamic networks and DMN was associated with greater intake of protein in the first week (β = 0.17; 95% CI 0.11, 0.23, p < 0.001) but lower intakes of fat (β = − 0.06; 95% CI − 0.09, − 0.02, p = 0.001) and carbohydrates (β = − 0.03; 95% CI − 0.04, − 0.01, p = 0.003). Connectivity strength was also associated with protein intake during the first month (β = 0.22; 95% CI 0.06, 0.37, p = 0.006). Importantly, greater thalamic-DMN connectivity strength was associated with higher processing speed indices (β = 26.9; 95% CI 4.21, 49.49, p = 0.02) and visual processing scores (β = 9.03; 95% CI 2.27, 15.79, p = 0.009). Optimizing early protein intake may contribute to promoting long-term brain health in preterm-born children.
Ketogenic Diet Effects On Inflammatory Allodynia And Ongoing Pain In Rodents,
2021
Trinity College Hartford
Ketogenic Diet Effects On Inflammatory Allodynia And Ongoing Pain In Rodents, David N. Ruskin, Isabella C. Sturdevant, Livia S. Wyss, Susan A. Masino
Faculty Scholarship
© 2021, The Author(s). Ketogenic diets are very low carbohydrate, high fat, moderate protein diets used to treat medication-resistant epilepsy. Growing evidence suggests that one of the ketogenic diet’s main mechanisms of action is reducing inflammation. Here, we examined the diet’s effects on experimental inflammatory pain in rodent models. Young adult rats and mice were placed on the ketogenic diet or maintained on control diet. After 3–4 weeks on their respective diets, complete Freund’s adjuvant (CFA) was injected in one hindpaw to induce inflammation; the contralateral paw was used as the control. Tactile sensitivity (von Frey ...
Structural Alterations In Cortical And Thalamocortical White Matter Tracts After Recovery From Prefrontal Cortex Lesions In Macaques,
2021
The University of Western Ontario
Structural Alterations In Cortical And Thalamocortical White Matter Tracts After Recovery From Prefrontal Cortex Lesions In Macaques, Ramina Adam, David J. Schaeffer, Kevin Johnston, Ravi S. Menon, Stefan Everling
Brain and Mind Institute Researchers' Publications
Unilateral damage to the frontoparietal network typically impairs saccade target selection within the contralesional visual hemifield. Severity of deficits and the degree of recovery have been associated with widespread network dysfunction, yet it is not clear how these behavioural and functional brain changes relate with the underlying structural white matter tracts. Here, we investigated whether recovery after unilateral prefrontal cortex (PFC) lesions was associated with changes in white matter microstructure across large-scale frontoparietal cortical and thalamocortical networks. Diffusion-weighted imaging was acquired in four male rhesus macaques at pre-lesion, week 1, and week 8-16 post-lesion when target selection deficits largely recovered ...
The Effect Of Polyunsaturated And Saturated Fatty Acids On Seizure Presence And Severity In A Cohort Of Subjects In An Epilepsy Monitoring Unit,
2021
University of Nebraska Medical Center
The Effect Of Polyunsaturated And Saturated Fatty Acids On Seizure Presence And Severity In A Cohort Of Subjects In An Epilepsy Monitoring Unit, Jana K. Wells
Theses & Dissertations
Ketogenic diet therapies (KDTs) have been used to treat epilepsy for nearly 100 years. Although effective, restrictive diet patterns and unknown impacts on long-term health outcomes often prevent their use as first-line therapy. To date, a distinct mechanism of action for KDTs has not been determined and evidence suggests fatty acids (FAs) may play a role in eliciting anti-seizure effects. This dissertation aimed to provide insights into the effect of polyunsaturated fatty acids (PUFAs) and saturated fatty acids (SFAs) on seizure presence and severity through the analysis of dietary intake in a cohort of patients admitted to an epilepsy monitoring ...
Sarcopenia Screening By Registered Dietitian Nutritionists (Rdns) In The United States (U.S.),
2021
East Tennessee State University
Sarcopenia Screening By Registered Dietitian Nutritionists (Rdns) In The United States (U.S.), Madison Marcom
Electronic Theses and Dissertations
Sarcopenia is a disease of muscle wasting primarily seen in older adults. Although this term was first coined over three decades ago, there is a lack of consensus on a definition, screening criteria, and treatment protocol for sarcopenia. The primary purpose of this study is to determine whether registered dietitian nutritionists (RDNs) in the United States (U.S.) screen for sarcopenia. Study participants were recruited through a randomized email list and included RDNs throughout the U.S. Respondents completed a survey questioning knowledge of sarcopenia, screening tools and company protocols in place, and the need and desire for sarcopenia education ...
Muting, Not Fragmentation, Of Functional Brain Networks Under General Anesthesia,
2021
Queen's University, Centre for Neuroscience Studies, Kingston
Muting, Not Fragmentation, Of Functional Brain Networks Under General Anesthesia, Corson N. Areshenkoff, Joseph Y. Nashed, R. Matthew Hutchison, Melina Hutchison, Ron Levy, Douglas J. Cook, Ravi S. Menon, Stefan Everling, Jason P. Gallivan
Brain and Mind Institute Researchers' Publications
© 2021 Changes in resting-state functional connectivity (rs-FC) under general anesthesia have been widely studied with the goal of identifying neural signatures of consciousness. This work has commonly revealed an apparent fragmentation of whole-brain network structure during unconsciousness, which has been interpreted as reflecting a break-down in connectivity and a disruption of the brain's ability to integrate information. Here we show, by studying rs-FC under varying depths of isoflurane-induced anesthesia in nonhuman primates, that this apparent fragmentation, rather than reflecting an actual change in network structure, can be simply explained as the result of a global reduction in FC. Specifically ...
Assessment Of Strengths-Based Interventions On First-Year Medical Students,
2021
Olivet Nazarene University
Assessment Of Strengths-Based Interventions On First-Year Medical Students, Linnette C. White
Scholar Week 2016 - present
In the quest for a doctoral degree many candidates fail to meet their milestone accomplishment. It is estimated that approximately 30% of individuals that pursue a doctoral degree will not finish. Medical school has been found to be a very intensive program to pursue for many who begin the journey. Despite its difficulty, 81.6 % to 84.3% of medical students achieve the status of medical practitioner within a three-to-four-year program. Despite the seemingly high completion rate, the achievement gap has future implications on physician shortages. The researcher conducted a quantitative study to determine the impact training first-year medical students ...
Implications Of The Quantum Dna Model For Information Sciences,
2021
University of Tennessee Health Science Center
Implications Of The Quantum Dna Model For Information Sciences, F. Matthew Mihelic
Faculty Publications
The DNA molecule can be modeled as a quantum logic processor, and this model has been supported by pilot research that experimentally demonstrated non-local communication between cells in separated cell cultures. This modeling and pilot research have important implications for information sciences, providing a potential architecture for quantum computing that operates at room temperature and is scalable to millions of qubits, and including the potential for an entanglement communication system based upon the quantum DNA architecture. Such a system could be used to provide non-local quantum key distribution that could not be blocked by any shielding or water depth, would ...
Magnetic Vector Potential Manipulation Of Majorana Fermions In Dna Quantum Logic,
2021
University of Tennessee Health Science Center
Magnetic Vector Potential Manipulation Of Majorana Fermions In Dna Quantum Logic, F. Matthew Mihelic
Faculty Publications
In the quantum logic of the DNA molecule, electrons are held and conducted coherently as spinless Cooper pairs and are shielded from electromagnetic energy by a Faraday cage effect of the double lipid bilayer of the nuclear membrane. The magnetic vector potential generated by cellular depolarization can synchronize logical activity in portions of the DNA molecule by affecting spin directions of appropriately oriented spinless electrons via the Aharonov-Bohm effect, but is not blocked by that Faraday cage effect. Within the logically and thermodynamically reversible chiral enantiomeric symmetry of the deoxyribose moieties the decoherent transition of Cooper pair to Dirac pair ...
B36: Comparing The Nephrotoxic Effects Of Cisplatin In Combination With Docetaxel Or 5-Fluorouracil,
2021
Roseman University of Health Sciences
B36: Comparing The Nephrotoxic Effects Of Cisplatin In Combination With Docetaxel Or 5-Fluorouracil, Ria Lei Marie Natividad
Annual Research Symposium
No abstract provided.
B35: Development And Validation Of A Stability Indicating Hplc Method For Quantification Of Estriol In Compounded Glycerinated Gelatin Troches,
2021
Roseman University of Health Sciences
B35: Development And Validation Of A Stability Indicating Hplc Method For Quantification Of Estriol In Compounded Glycerinated Gelatin Troches, Tayler Hutto
Annual Research Symposium
No abstract provided.
B30: Identifying New G Protein Coupled Receptor Kinase 6 Substrates Among Proteins Closely Linked To Prognoses Of Pancreatic Cancer,
2021
Roseman University of Health Sciences
B30: Identifying New G Protein Coupled Receptor Kinase 6 Substrates Among Proteins Closely Linked To Prognoses Of Pancreatic Cancer, Christine Taing, Jelena Jovanovic, Nicole Khalil, Christopher So
Annual Research Symposium
No abstract provided.
B29: Exploring The Role Of G Protein Coupled Receptor Kinases In Modulating Behaviors To Fluoxetine Using Caenorhabditis Elegans As An Experimental Model,
2021
Roseman University of Health Sciences
B29: Exploring The Role Of G Protein Coupled Receptor Kinases In Modulating Behaviors To Fluoxetine Using Caenorhabditis Elegans As An Experimental Model, Victoria Pang
Annual Research Symposium
No abstract provided.
B28: Evaluating The Chemotherapeutic Effects Of The Fac Regimen In Mda Mb 231 Breast Cancer Cells With Reduced Beta Arrestin 2 Expression Levels,
2021
Roseman University of Health Sciences
B28: Evaluating The Chemotherapeutic Effects Of The Fac Regimen In Mda Mb 231 Breast Cancer Cells With Reduced Beta Arrestin 2 Expression Levels, Angelina Marcee
Annual Research Symposium
No abstract provided.
B27: Evaluating The Chemotherapeutic Effects Of The Fac Regimen In Mda Mb 231 Breast Cancer Cells With Reduced G Protein Coupled Receptor Kinase 2 Expression,
2021
Roseman University of Health Sciences
B27: Evaluating The Chemotherapeutic Effects Of The Fac Regimen In Mda Mb 231 Breast Cancer Cells With Reduced G Protein Coupled Receptor Kinase 2 Expression, Samantha Bodan
Annual Research Symposium
No abstract provided.
B26: Fastidious Bacteria Grow Better In The Right Media,
2021
Roseman University of Health Sciences
B26: Fastidious Bacteria Grow Better In The Right Media, Kira Jorgensen Duus
Annual Research Symposium
Fastidious Bacteria Grow Better in the Right Media
Purpose: Nisseria gonorrheae is a common bacteria that causes a sexually transmitted disease. This disease can cause significant discomfort for both men and women, which can lead to infertility. Treatment of the bacterium has been a simple matter of diagnosis and antibiotic treatment in the past, but now this bacterium is becoming increasingly antibiotic resistant because of excessive antimicrobial treatments. A novel way to treat N. gonorrheae infection involves focusing on finding bacteriophage that targets N. gonorrheae. N. gonorrheae broth cultures are used to enrich for bacteriophage; but the current standard medium ...
B25: Generation And Characterization Of Sars-Cov-2 Spike Protein-Pseudotyped Lentivirus Particles For Use In Neutralizing Antibody Titer Testing Of Human Serum,
2021
Roseman University of Health Sciences
B25: Generation And Characterization Of Sars-Cov-2 Spike Protein-Pseudotyped Lentivirus Particles For Use In Neutralizing Antibody Titer Testing Of Human Serum, Luis Sanchez
Annual Research Symposium
No abstract provided.
B24: Efficacy Of Scaffold Mediated Localized Chemotherapy In Cancer: A Systematic Review,
2021
Roseman University of Health Sciences
B24: Efficacy Of Scaffold Mediated Localized Chemotherapy In Cancer: A Systematic Review, Archana Gupta
Annual Research Symposium
No abstract provided.
B21: Exposure To Vape Smoke Enhances Sperm Mitochondrial Respiration In Mature Mice.,
2021
Brigham Young University
B21: Exposure To Vape Smoke Enhances Sperm Mitochondrial Respiration In Mature Mice., Jeremy Y. Saito
Annual Research Symposium
No abstract provided.
B14: Angiogenic Potential Of Oral Cavity Derived Mesenchymal Stem Cells And Its Secretomes: A Systematic Review,
2021
Dr. D. Y. Patil Vidyapeeth
B14: Angiogenic Potential Of Oral Cavity Derived Mesenchymal Stem Cells And Its Secretomes: A Systematic Review, Madhura Rajendra Shekatkar
Annual Research Symposium
No abstract provided.
