Open Access. Powered by Scholars. Published by Universities.®

Medical Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

4,836 Full-Text Articles 12,964 Authors 859,399 Downloads 149 Institutions

All Articles in Medical Sciences

Faceted Search

4,836 full-text articles. Page 1 of 148.

Current Understanding Of The Mechanism Of Action Of The Antiepileptic Drug Lacosamide, Michael A. Rogawski, Azita Tofighy, H Steve White, Alain Matagne, Christian Wolff 2015 University of California - Davis

Current Understanding Of The Mechanism Of Action Of The Antiepileptic Drug Lacosamide, Michael A. Rogawski, Azita Tofighy, H Steve White, Alain Matagne, Christian Wolff

Michael A. Rogawski

The antiepileptic drug lacosamide [(R)-2-acetamido-N-benzyl-3-methoxypropanamide], a chiral functionalized amino acid, was originally identified by virtue of activity in the mouse and rat maximal electroshock (MES) test. Attention was drawn to lacosamide because of its high oral potency and stereoselectivity. Lacosamide is also active in the 6 Hz seizure model but inactive against clonic seizures in rodents induced by subcutaneous pentylenetetrazol, bicuculline and picrotoxin. It is also ineffective in genetic models of absence epilepsy. At doses greater than those required to confer protection in the MES test, lacosamide inhibits behavioral and electrographic seizures in hippocampal kindled rats. It also effectively ...


Viability Of Developmental Stages Of Schistosoma Mansoni Quantified With Xcelligence Worm Real-Time Motility Assay (Xworm)., Gabriel Rinaldi, Alex Loukas, Paul J. Brindley, Jeff T. Irelan, Michael J. Smout 2015 George Washington University

Viability Of Developmental Stages Of Schistosoma Mansoni Quantified With Xcelligence Worm Real-Time Motility Assay (Xworm)., Gabriel Rinaldi, Alex Loukas, Paul J. Brindley, Jeff T. Irelan, Michael J. Smout

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Infection with helminth parasites causes morbidity and mortality in billions of people and livestock worldwide. Where anthelmintic drugs are available, drug resistance is a major problem in livestock parasites, and a looming threat to public health. Monitoring the efficacy of these medicines and screening for new drugs has been hindered by the lack of objective, high-throughput approaches. Several cell monitoring technologies have been adapted for parasitic worms, including video-, fluorescence-, metabolism enzyme- and impedance-based tools that minimize the screening bottleneck. Using the xCELLigence impedance-based system we previously developed a motility-viability assay that is applicable for a range of helminth parasites ...


Ngo's Bpa Report Intended To Frighten, Not Enlighten., Robert L. Brent Dr. 2015 duPont Hosp for Children

Ngo's Bpa Report Intended To Frighten, Not Enlighten., Robert L. Brent Dr.

The Selected Works of Robert Brent

None


The Kinetics Of Cystatin C: A Marker For Dialysis Adequacy, Huang S. Shih-Han 2015 The University of Western Ontario

The Kinetics Of Cystatin C: A Marker For Dialysis Adequacy, Huang S. Shih-Han

Electronic Thesis and Dissertation Repository

When 90% or more of native kidney function is lost, renal replacement therapy must be initiated to sustain life. Renal transplantation is the preferred method, but availability is limited. The ideal dialysis prescription remains elusive. Small molecular weight molecules (such as urea and creatinine) have been used as markers of both kidney (native and transplant) and dialysis toxin clearance (function), but there are pitfalls in using these markers to assess total ‘renal’ dose (kidney plus dialysis). Body weight, gender and other factors also affect the concentrations of these small molecules, but not cystatin C. Furthermore, cystatin C has been shown ...


Towards Adaptive Radiotherapy Through Development Of Treatment Response Prediction, Anthony V. Lausch 2015 The University of Western Ontario

Towards Adaptive Radiotherapy Through Development Of Treatment Response Prediction, Anthony V. Lausch

Electronic Thesis and Dissertation Repository

Despite modern treatment advances, overall survival (OS) remains poor for many cancers such as liver and brain. Cancer is a fundamentally heterogeneous and adaptable disease and therefore personalized adaptive treatment strategies may be a key towards improving OS. Radiotherapy, a commonly used cancer treatment technique which employs ionizing radiation to kill tumours, holds promise for delivering adaptive treatment. However, effective adaptation requires the ability to assess and predict tumour treatment response. Therefore development of treatment response prediction tools represents a critical first step towards improving patient outcomes via treatment adaptation. The overall goal of this thesis is to develop treatment ...


Subclavian Vein Stenosis/Occlusion Following Transvenous Cardiac Pacemaker And Defibrillator Implantation: Incidence, Pathophysiology And Current Management, Brian O'Leary, Suhail Allaqaband 2015 Aurora Health Care

Subclavian Vein Stenosis/Occlusion Following Transvenous Cardiac Pacemaker And Defibrillator Implantation: Incidence, Pathophysiology And Current Management, Brian O'Leary, Suhail Allaqaband

Journal of Patient-Centered Research and Reviews

Subclavian vein stenosis is a common, but usually asymptomatic, complication following cardiac device placement. In addition to reviewing the literature on incidence, pathogenesis and management options for this important clinical problem, we describe two cases of symptomatic subclavian vein occlusion following pacemaker/defibrillator placement and successful treatment with venoplasty and stenting.


Vascular Medicine: A ‘Primary’ Specialty, Mark W. Mewissen 2015 Aurora Health Care Vascular Center

Vascular Medicine: A ‘Primary’ Specialty, Mark W. Mewissen

Journal of Patient-Centered Research and Reviews

N/A


Investigation Of Endogenous In-Vivo Sodium Concentration In Human Prostate Cancer Measured With 23na Magnetic Resonance Imaging, Justin C. Peterson 2015 The University of Western Ontario

Investigation Of Endogenous In-Vivo Sodium Concentration In Human Prostate Cancer Measured With 23na Magnetic Resonance Imaging, Justin C. Peterson

Electronic Thesis and Dissertation Repository

Prostate cancer (PCa) is the most common malignancy in men. Aggressive prostate tumours must be identified, differentiated from indolent tumours, and treated to ensure survival of the patient. Currently, clinicians use a combination of multi-parametric magnetic resonance imaging (mpMRI) contrasts to improve PCa detection. While these techniques provide very good spatial resolution, the specificity is often insufficient to unequivocally identify malignant lesions.

Utilizing specialized MRI hardware developed for sensitive in-vivo detection of sodium, this work has investigated differences in sodium concentration between healthy and malignant prostate tissue. Patients with biopsy-proven PCa underwent conventional mpMRI and sodium MRI followed by radical ...


Lc3b Globular Structures Correlate With Survival In Esophageal Adenocarcinoma., Shereen El-Mashed, Tracey R. O'Donovan, Elaine W. Kay, Ayat R. Abdallah, Mary-Clare Cathcart, Jacintha O'Sullivan, Anthony O'Grady, John Reynolds, Seamus O'Reilly, Gerald C. O'Sullivan, Sharon L. McKenna 2015 University College Cork

Lc3b Globular Structures Correlate With Survival In Esophageal Adenocarcinoma., Shereen El-Mashed, Tracey R. O'Donovan, Elaine W. Kay, Ayat R. Abdallah, Mary-Clare Cathcart, Jacintha O'Sullivan, Anthony O'Grady, John Reynolds, Seamus O'Reilly, Gerald C. O'Sullivan, Sharon L. Mckenna

Pathology Articles

BACKGROUND: Esophageal adenocarcinoma has the fastest growing incidence of any solid tumor in the Western world. Prognosis remains poor with overall five-year survival rates under 25 %. Only a limited number of patients benefit from chemotherapy and there are no biomarkers that can predict outcome. Previous studies have indicated that induction of autophagy can influence various aspects of tumor cell biology, including chemosensitivity. The objective of this study was to assess whether expression of the autophagy marker (LC3B) correlated with patient outcome.

METHODS: Esophageal adenocarcinoma tumor tissue from two independent sites, was examined retrospectively. Tumors from 104 neoadjuvant naïve patients and ...


Electrochemical Characterization Of Protein Adsorption Onto Yngrt-Au And Vlgxe-Au Surfaces, Hanna Trzeciakiewicz, Jose Esteves-Villanueva, Rania Soudy, Kamaljit Kaur, Sanela Martic-Milne 2015 Oakland University

Electrochemical Characterization Of Protein Adsorption Onto Yngrt-Au And Vlgxe-Au Surfaces, Hanna Trzeciakiewicz, Jose Esteves-Villanueva, Rania Soudy, Kamaljit Kaur, Sanela Martic-Milne

Pharmacy Faculty Articles and Research

The adsorption of the proteins CD13, mucin and bovine serum albumin on VLGXE-Au and YNGRT-Au interfaces was monitored by electrochemical impedance spectroscopy in the presence of [Fe(CN)6]3−/4−. The hydrophobicity of the Au surface was tailored using specific peptides, blocking agents and diluents. The combination of blocking agents (ethanolamine or n-butylamine) and diluents (hexanethiol or 2-mercaptoethanol) was used to prepare various peptide-modified Au surfaces. Protein adsorption onto the peptide-Au surfaces modified with the combination of n-butylamine and hexanethiol produced a dramatic decrease in the charge transfer resistance, Rct, for all three proteins. In contrast, polar peptide-surfaces induced ...


Characterization Of Maga Expression And Iron Uptake In P19 Cells: Implications For Use As A Gene-Based Contrast Agent, Linshan Liu 2015 The University of Western Ontario

Characterization Of Maga Expression And Iron Uptake In P19 Cells: Implications For Use As A Gene-Based Contrast Agent, Linshan Liu

Electronic Thesis and Dissertation Repository

Magnetic resonance imaging (MRI) is one of the non-invasive imaging modalities used in longitudinal cell tracking. Previous studies suggest that MagA, a putative iron transport protein from magnetotactic bacteria, is a useful gene-based magnetic resonance contrast agent. Hemagglutinin (HA)-tagged MagA was stably expressed in undifferentiated embryonic mouse teratocarcinoma, multipotent P19 stem cells to provide a suitable model for tracking these cells during differentiation. Western blot and immunocytochemistry confirmed the expression and membrane localization of MagA-HA in P19 cells. Elemental iron analysis using inductively-coupled plasma mass spectrometry revealed significant iron uptake in both parental and MagA-HA-expressing P19 cells, cultured in ...


Modern Study Of Environmental Pollution From The Emission Of Alpha Particles In Human Blood Samples In The City Of Najaf, Iraq, Basim A. Almayahi 2015 USM

Modern Study Of Environmental Pollution From The Emission Of Alpha Particles In Human Blood Samples In The City Of Najaf, Iraq, Basim A. Almayahi

21st International Conference on Environmental Indicators (ICEI 2015)

No abstract provided.


The Right Tool For The Job: Detection Of Soil-Transmitted Helminths In Areas Co-Endemic For Other Helminths, Maria V. Periago, Renata C. Diniz, Simone A. Pinto, Anna Yakovleva, David J. Diemert, Jeffrey M. Bethony, et al. 2015 George Washington University

The Right Tool For The Job: Detection Of Soil-Transmitted Helminths In Areas Co-Endemic For Other Helminths, Maria V. Periago, Renata C. Diniz, Simone A. Pinto, Anna Yakovleva, David J. Diemert, Jeffrey M. Bethony, Et Al.

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Due to the recent increased use of the McMaster (MM) fecal egg counting method for assessing benzimidazole drug efficacy for treating soil-transmitted helminth (STH) infections, the aim of the current study was to determine the operational value of including the MM method alongside the Kato-Katz (KK) fecal thick smear to increase the diagnostic sensitivity when STHs are co-endemic with trematode helminths (e.g., Schistosoma mansoni).

Methods

A cross-sectional study was conducted in school-aged children aged 4-18 years in the northeastern region of the State of Minas Gerais (Brazil), where Necator americanus, Ascaris lumbricoides, Trichuris trichiura, and S. mansoni are co-endemic ...


How Diet, Exercise, And Probiotics Influence Diversity In Gut Microbiota, Kristen Counsell 2015 Idaho State University

How Diet, Exercise, And Probiotics Influence Diversity In Gut Microbiota, Kristen Counsell

Skyline - The Big Sky Undergraduate Journal

Microorganisms are a fundamental part of life and essential to the mammalian digestive tract. Evolution has incorporated a vast number of intestinal alterations in morphology and physiology among the animal kingdom. When intestinal conditions change it alters the microbiota in the gut and digestive process. For certain chemical compounds to be broken down and absorbed, microbes with that ability must be present. Microbiota in the gut can also cause diseases such as irritable bowel syndrome (IBS) and colon cancer. One must maintain microbial diversity in the gut to stay healthy. To help improve and withhold diversity in the gut one ...


Mental Toughness And Coping Strategies In Collegiate Skiers, Julia Hayes 2015 Montana State University - Bozeman

Mental Toughness And Coping Strategies In Collegiate Skiers, Julia Hayes

Skyline - The Big Sky Undergraduate Journal

Pain is a mental construct that is seen as a warning signal to avoid injury. Athletes are able to overcome the mental roadblock of pain with many different coping strategies. Research has shown that pain coping mechanisms can help athletes to avoid the negative effect of pain on performance (Thelwell, Weston, Greenlees, 2005). Ignoring pain can be used to change pain perception. Pain tolerance has also been shown to increase with mental training during exercise, suggesting that specific coping mechanisms can have a strong impact on an athletes ability to maintain a high performance level during competition (Thelwell, 2005). The ...


Early Mobilization In The Critical Care Unit: A Review Of Adult And Pediatric Literature., Saoirse Cameron, Ian Ball, Gediminas Cepinskas, Karen Choong, Timothy J Doherty, Christopher G Ellis, Claudio M Martin, Tina S Mele, Michael Sharpe, J Kevin Shoemaker, Douglas D Fraser 2015 Western University

Early Mobilization In The Critical Care Unit: A Review Of Adult And Pediatric Literature., Saoirse Cameron, Ian Ball, Gediminas Cepinskas, Karen Choong, Timothy J Doherty, Christopher G Ellis, Claudio M Martin, Tina S Mele, Michael Sharpe, J Kevin Shoemaker, Douglas D Fraser

Medical Biophysics Publications

Early mobilization of critically ill patients is beneficial, suggesting that it should be incorporated into daily clinical practice. Early passive, active, and combined progressive mobilizations can be safely initiated in intensive care units (ICUs). Adult patients receiving early mobilization have fewer ventilator-dependent days, shorter ICU and hospital stays, and better functional outcomes. Pediatric ICU data are limited, but recent studies also suggest that early mobilization is achievable without increasing patient risk. In this review, we provide a current and comprehensive appraisal of ICU mobilization techniques in both adult and pediatric critically ill patients. Contraindications and perceived barriers to early mobilization ...


Development Of A Comprehensive Massively Parallel Sequencing Panel Of Single Nucleotide Polymorphism And Short Tandem Repeat Markers For Human Identification, David H. Warshauer B.S., M.S. 2015 University of North Texas Health Science Center at Fort Worth

Development Of A Comprehensive Massively Parallel Sequencing Panel Of Single Nucleotide Polymorphism And Short Tandem Repeat Markers For Human Identification, David H. Warshauer B.S., M.S.

Theses and Dissertations

Massively parallel sequencing (MPS) technologies allow for the detection of an unparalleled amount of genetic information with unprecedented speed and relative ease. These qualities make the technology desirable for generating DNA profiles that may be uploaded into forensic offender, arrestee, and family reference database files. This doctoral dissertation research was conducted under the hypothesis that MPS, with its exquisitely high throughput, can provide a system whereby reference samples can be typed for a large battery of markers, providing more discrimination power for forensic DNA typing and offering increased opportunities to develop investigative leads. The design and implementation of large marker ...


Thymic Involution Perturbs Negative Selection And Leads To Chronic Inflammation, Brandon D. Coder B.S. 2015 University of North Texas Health Science Center at Fort Worth

Thymic Involution Perturbs Negative Selection And Leads To Chronic Inflammation, Brandon D. Coder B.S.

Theses and Dissertations

The ubiquitous presence of chronic low-level pro-inflammatory factors in elderly individuals (termed inflammaging) is a significant risk factor for morbidity and mortality. The etiology of inflammaging is largely unknown. Recent evidence has identified the persistent activation of immune cells, thought to arise from latent viral infections, as key contributors towards the development of a chronic inflammatory environment. However, the contribution of autoreactive T cells towards the development of inflammaging has yet to be investigated. Another pervasive feature of the aging process is the age-related involution of the thymus gland, which has been linked with a predisposition toward developing autoimmunity. In ...


Optical Tracking System To Monitor Laparoscopic Training, William D. Rytlewski 2015 Grand Valley State University

Optical Tracking System To Monitor Laparoscopic Training, William D. Rytlewski

Masters Theses

Laparoscopic Surgery, also known as Minimally Invasive Surgery, is a surgical technique where surgeons perform surgery through small incisions in the patient’s abdomen using a camera to monitor the movements of the instruments inside the patient. In order for the surgery to be performed, the surgeon must possess a unique set of skills obtained through training using a variety of techniques. Simulators are the preferred method of training for laparoscopic surgery since they provide medical residents with real world scenarios as well as a tremendous amount of feedback on what he/she did wrong or right. However, due to ...


Standardization Of The Experimental Autoimmune Myasthenia Gravis (Eamg) Model By Immunization Of Rats With Torpedo Californica Acetylcholine Receptors- Recommendations For Methods And Experimental Designs., Mario Losen, Pilar Martinez-Martinez, Peter C. Molenaar, Konstantinos Lazaridis, Socrates Tzartos, Talma Brenner, Rui-Sheng Duan, Jie Luo, Jon Lindstrom, Linda Kusner 2015 George Washington University

Standardization Of The Experimental Autoimmune Myasthenia Gravis (Eamg) Model By Immunization Of Rats With Torpedo Californica Acetylcholine Receptors- Recommendations For Methods And Experimental Designs., Mario Losen, Pilar Martinez-Martinez, Peter C. Molenaar, Konstantinos Lazaridis, Socrates Tzartos, Talma Brenner, Rui-Sheng Duan, Jie Luo, Jon Lindstrom, Linda Kusner

Pharmacology and Physiology Faculty Publications

Myasthenia gravis (MG) with antibodies against the acetylcholine receptor (AChR) is characterized by a chronic, fatigable weakness of voluntary muscles. The production of autoantibodies involves the dysregulation of T cells which provide the environment for the development of autoreactive B cells. The symptoms are caused by destruction of the postsynaptic membrane and degradation of the AChR by IgG autoantibodies, predominantly of the G1 and G3 subclasses. Active immunization of animals with AChR from mammalian muscles, AChR from Torpedo or Electrophorus electric organs, and recombinant or synthetic AChR fragments generates a chronic model of MG, termed experimental autoimmune myasthenia gravis (EAMG ...


Digital Commons powered by bepress