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Chitosan Microparticles: A Potential Therapeutic Intervention For Alzheimer's Disease With Cerebral Amyloid Angiopathy, Tanya L. Cupino, Matthew Zabel 2017 Loma Linda University

Chitosan Microparticles: A Potential Therapeutic Intervention For Alzheimer's Disease With Cerebral Amyloid Angiopathy, Tanya L. Cupino, Matthew Zabel

Loma Linda University Student Journal

Title: Chitosan Microparticles: A Potential Therapeutic Intervention for Alzheimer's Disease with Cerebral Amyloid Angiopathy

Introduction: Alzheimer’s Disease (AD) is an irreversible neurodegenerative disorder characterized by amyloid beta (Ab) plaques in the brain parenchyma. Cerebral Amyloid Angiopathy (CAA), a common comorbidity with AD, is defined by Ab plaques form in the walls of the cerebral vessels. The past decade has seen significant progress in plaque diagnosis without similar therapeutic gains. In patients with CAA/AD the vascular plaques activate a part of innate immune system called the complement cascade, leading to lysis of cerebrovascular smooth-muscle cells (cvSMC) and vascular ...


Primary Pulmonary Meningioma Mimicking Lung Metastases, Sameer Tolay MD, Brian J. Patson MD, Sherry Q. Li MD 2017 Lehigh Valley Health Network

Primary Pulmonary Meningioma Mimicking Lung Metastases, Sameer Tolay Md, Brian J. Patson Md, Sherry Q. Li Md

Sherry Li, M.D.

No abstract provided.


We Have No Real Evidence Related To Anticoagulation Plus Aspirin For Stroke Prevention In Atrial Fibrillation, Yuxiang Wang 2017 wayne state university school of medicine

We Have No Real Evidence Related To Anticoagulation Plus Aspirin For Stroke Prevention In Atrial Fibrillation, Yuxiang Wang

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Flaker GC, Gruber M, Connolly SJ, et al. Risks and benefits of combining aspirin with anticoagulant therapy in patients with atrial fibrillation: an exploratory analysis of stroke prevention using an oral thrombin inhibitor in atrial fibrillation (SPORTIF) trials. Am Heart J. 2006;152:967-973. doi: 10.1016/j.ahj.2006.06.024


Parts Of The Whole: Error Estimation For Science Students, Dorothy Wallace 2017 Dartmouth College

Parts Of The Whole: Error Estimation For Science Students, Dorothy Wallace

Numeracy

It is important for science students to understand not only how to estimate error sizes in measurement data, but also to see how these errors contribute to errors in conclusions they may make about the data. Relatively small errors in measurement, errors in assumptions, and roundoff errors in computation may result in large error bounds on computed quantities of interest. In this column, we look closely at a standard method for measuring the volume of cancer tumor xenografts to see how small errors in each of these three factors may contribute to relatively large observed errors in recorded tumor volumes.


Cleavage Of Dfna5 By Caspase-3 During Apoptosis Mediates Progression To Secondary Necrotic/Pyroptotic Cell Death., Corey Rogers, Teresa Fernandes-Alnemri, Lindsey Mayes, Diana Alnemri, Gino Cingolani, Emad S. Alnemri 2017 Thomas Jefferson University

Cleavage Of Dfna5 By Caspase-3 During Apoptosis Mediates Progression To Secondary Necrotic/Pyroptotic Cell Death., Corey Rogers, Teresa Fernandes-Alnemri, Lindsey Mayes, Diana Alnemri, Gino Cingolani, Emad S. Alnemri

Department of Biochemistry and Molecular Biology Faculty Papers

Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis. The mechanism by which this occurs is unknown. Here we show that caspase-3 cleaves the GSDMD-related protein DFNA5 after Asp270 to generate a necrotic DFNA5-N fragment that targets the plasma membrane to induce secondary necrosis/pyroptosis. Cells that express DFNA5 progress to secondary necrosis, when stimulated with apoptotic triggers such as etoposide or vesicular stomatitis virus infection, but disassemble into small apoptotic bodies when ...


Traumatic Brain Injury Screening Tools In Primary Care, Lee John Bizon Jr 2017 University of Vermont

Traumatic Brain Injury Screening Tools In Primary Care, Lee John Bizon Jr

Graduate College Dissertations and Theses

Traumatic brain injuries are a significant health concern, being responsible for over 52,000 deaths each year. Unfortunately, many traumatic brain injuries often go misdiagnosed or undiagnosed. Primary care providers are the principal and first source of medical contact for individuals, meaning that they are vital in the diagnosis of previous traumatic brain injuries in order to prevent future sequelae. There are currently several well-validated screening tools currently available for use by primary care providers. This study uses a self-reported survey to determine which of these tools are used by primary care nurse practitioners from a northern New England state ...


Reliability Issues In Imaging Genetics, Annika Eriksson 2017 Oregon Health & Science University

Reliability Issues In Imaging Genetics, Annika Eriksson

Scholar Archive

No abstract provided.


Integrative Genomic And Transcriptomic Analysis For Pinpointing Recurrent Alterations Of Plant Homeodomain Genes And Their Clinical Significance In Breast Cancer, Huimei Yu, Yuanyuan Jiang, Lanxin Liu, Wenqi Shan, Xiaofang Chu, Zhe Yang, Zeng-Quan Yang 2016 Department of Oncology, Wayne State University School of Medicine

Integrative Genomic And Transcriptomic Analysis For Pinpointing Recurrent Alterations Of Plant Homeodomain Genes And Their Clinical Significance In Breast Cancer, Huimei Yu, Yuanyuan Jiang, Lanxin Liu, Wenqi Shan, Xiaofang Chu, Zhe Yang, Zeng-Quan Yang

Oncology Faculty Publications

A wide range of the epigenetic effectors that regulate chromatin modification, gene expression, genomic stability, and DNA repair contain structurally conserved domains called plant homeodomain (PHD) fingers. Alternations of several PHD finger-containing proteins (PHFs) due to genomic amplification, mutations, deletions, and translocations have been linked directly to various types of cancer. However, little is known about the genomic landscape and the clinical significance of PHFs in breast cancer. Hence, we performed a large-scale genomic and transcriptomic analysis of 98 PHF genes in breast cancer using TCGA and METABRIC datasets and correlated the recurrent alterations with clinicopathological features and survival of ...


The Accuracy In The 6-Minute Walk Test In Determining V02peak In Cancer Survivors, Deandra Elcock 2016 University of Northern Colorado

The Accuracy In The 6-Minute Walk Test In Determining V02peak In Cancer Survivors, Deandra Elcock

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Peak oxygen consumption (VO2peak) is critical for developing and implementing an exercise prescription to guide a cancer survivor’s rehabilitative exercise program. The Rocky Mountain Cancer Rehabilitation Institute’s (RMCRI) treadmill protocol is cancer-specific and accurately determines VO2peak; yet many clinicians are choosing a less strenuous protocol, the 6 Minute Walk Test (6MWT), to determine VO2peak. However, the 6MWT may yield inaccurate measurements. Purpose: To determine the accuracy of the VO2peak value from the 6MWT compared to the VO2peak value from the RMCRI treadmill protocol for cancer survivors. Methods: Thirty cancer survivors from RMCRI participated. Each participant engaged in the ...


Review Of: Lewis' Dictionary Of Toxicology (Robert A. Lewis, Ed.; Lewis Publishers 1998), Dana E. Evans 2016 University of New Hampshire

Review Of: Lewis' Dictionary Of Toxicology (Robert A. Lewis, Ed.; Lewis Publishers 1998), Dana E. Evans

RISK: Health, Safety & Environment

Review of the book: Lewis' Dictionary of Toxicology (Robert A. Lewis, ed.; Lewis Publishers 1998). About the author, acknowledgments, alphabetical listing of terms defined. ISBN 1-56670-223-2; [1127 pp. $84.95. Hardbound. 2000 Corporate Blvd. N.W., Boca Raton, FL 33431.]


Genetic Monitoring In The Workplace: A Tool Not A Solution, Lillian Trettin, Catherine Musham, Richard Jablonski 2016 University of New Hampshire

Genetic Monitoring In The Workplace: A Tool Not A Solution, Lillian Trettin, Catherine Musham, Richard Jablonski

RISK: Health, Safety & Environment

The authors differentiate between genetic monitoring and screening, and discuss the potential risks and benefits of predictive testing technologies.


Combatting The Organ Deficit, Jessica Berg 2016 University of Wyoming

Combatting The Organ Deficit, Jessica Berg

Honors Theses AY 16/17

Since its beginning in 1954 organ transplantation has become the leading life-saving treatment worldwide for end-stage organ failure. In the past few decades organ transplantation has become so successful that now the number of people in need of a life-saving organ vastly outnumbers the supply of organs available. If this deficit remains unaddressed the number of people that die each day due to organ failure will increase exponentially. Fortunately, this is a problem that can be solved from many angles.

This paper will present possible solutions to the organ crisis by examining the possible positive effects of implementing a mandated ...


Calcium Uptake Hotspots In The Mitochondria Of Cardiac Muscle At The Interface With Dyadic Sr, Sergio De La Fuente, Celia Fernandez-Sanz, Caitlin Vail, Elorm J. Agra, Kira Holmstrom, Junhui Sun, Jyotsna Mishra, Toren Finkel, Elizabeth Murphy, Suresh K. Joseph, Shey-Shing Sheu, György Csordás 2016 Thomas Jefferson University

Calcium Uptake Hotspots In The Mitochondria Of Cardiac Muscle At The Interface With Dyadic Sr, Sergio De La Fuente, Celia Fernandez-Sanz, Caitlin Vail, Elorm J. Agra, Kira Holmstrom, Junhui Sun, Jyotsna Mishra, Toren Finkel, Elizabeth Murphy, Suresh K. Joseph, Shey-Shing Sheu, György Csordás

Pathology, Anatomy and Cell Biology Posters

Introduction

• Control of the mitochondrial ATP production by SR-derived Ca2+ signals includes local, nanodomain Ca2+ transfer from ryanodine receptors (RyR2) to the mitochondrial matrix (excitation-bioenergetics coupling).

• Ca2+ crosses the inner mitochondrial membrane (IMM) via the mtCU, a low-affinity Ca2+-activated Ca2+ channel complex.

• The surface area of cardiac IMM is extensively enhanced by cristae folding; however, mitoplast patch clamp studies showed mtCU current density the lowest amongst a range of tissues (Fieni 2012. Nat Commun).


Initiator Trna Genes Template The 3' Cca End At High Frequencies In Bacteria., David H. Ardell, Ya-Ming Hou 2016 University of California

Initiator Trna Genes Template The 3' Cca End At High Frequencies In Bacteria., David H. Ardell, Ya-Ming Hou

Department of Biochemistry and Molecular Biology Faculty Papers

BACKGROUND: While the CCA sequence at the mature 3' end of tRNAs is conserved and critical for translational function, a genetic template for this sequence is not always contained in tRNA genes. In eukaryotes and Archaea, the CCA ends of tRNAs are synthesized post-transcriptionally by CCA-adding enzymes. In Bacteria, tRNA genes template CCA sporadically.

RESULTS: In order to understand the variation in how prokaryotic tRNA genes template CCA, we re-annotated tRNA genes in tRNAdb-CE database version 0.8. Among 132,129 prokaryotic tRNA genes, initiator tRNA genes template CCA at the highest average frequency (74.1%) over all functional classes ...


An Examination Of The Neural Unreliability Thesis Of Autism, John Butler, Sophie Molholm, Gizely Andrade, John J. Foxe 2016 Dublin Institute of Technology

An Examination Of The Neural Unreliability Thesis Of Autism, John Butler, Sophie Molholm, Gizely Andrade, John J. Foxe

Articles

An emerging neuropathological theory of Autism, referred to here as “the neural unreliability thesis,” proposes greater variability in moment-to-moment cortical representation of environmental events, such that the system shows general instability in its impulse response function. Leading evidence for this thesis derives from functional neuroimaging, a methodology ill-suited for detailed assessment of sensory transmission dynamics occurring at the millisecond scale. Electrophysiological assessments of this thesis, however, are sparse and unconvincing. We conducted detailed examination of visual and somatosensory evoked activity using high-density electrical mapping in individuals with autism (N = 20) and precisely matched neurotypical controls (N = 20), recording large numbers ...


Cardiac Specific Overexpression Of Mitochondrial Omi/Htra2 Induces Myocardial Apoptosis And Cardiac Dysfunction., Ke Wang, Yuexing Yuan, Xin Liu, Wayne Bond Lau, Lin Zuo, Xiaoliang Wang, Lu Ma, Kun Jiao, Jianyu Shang, Wen Wang, Xinliang Ma, Huirong Liu 2016 Capital Medical University

Cardiac Specific Overexpression Of Mitochondrial Omi/Htra2 Induces Myocardial Apoptosis And Cardiac Dysfunction., Ke Wang, Yuexing Yuan, Xin Liu, Wayne Bond Lau, Lin Zuo, Xiaoliang Wang, Lu Ma, Kun Jiao, Jianyu Shang, Wen Wang, Xinliang Ma, Huirong Liu

Department of Emergency Medicine Faculty Papers

Myocardial apoptosis is a significant problem underlying ischemic heart disease. We previously reported significantly elevated expression of cytoplasmic Omi/HtrA2, triggers cardiomyocytes apoptosis. However, whether increased Omi/HtrA2 within mitochondria itself influences myocardial survival in vivo is unknown. We aim to observe the effects of mitochondria-specific, not cytoplasmic, Omi/HtrA2 on myocardial apoptosis and cardiac function. Transgenic mice overexpressing cardiac-specific mitochondrial Omi/HtrA2 were generated and they had increased myocardial apoptosis, decreased systolic and diastolic function, and decreased left ventricular remodeling. Transiently or stably overexpression of mitochondria Omi/HtrA2 in H9C2 cells enhance apoptosis as evidenced by elevated caspase-3, -9 ...


Very Rapid Onset Cannabis Dependence Risk In Relation To Co-Occurring Use Of Other Psychoactive Drugs, Olga A. Vsevolozhskaya, Fernando A. Wagner, James C. Anthony 2016 University of Kentucky

Very Rapid Onset Cannabis Dependence Risk In Relation To Co-Occurring Use Of Other Psychoactive Drugs, Olga A. Vsevolozhskaya, Fernando A. Wagner, James C. Anthony

Biostatistics Presentations

Background: Epidemiological estimates for lifetime cumulative incidence indicate that for every 9-11 who start using cannabis, one becomes a case of the cannabis dependence syndrome (CDS) – i.e., roughly 9%-11%. More recent estimates clarify that CDS risk might be much lower among ’cannabis only’ users, due in part to the fact that many ’cannabis only’ users try the drug a few times and never again. We turned to Hill functional analysis in order to study CDS probability soon after 1st cannabis use, estimated across strata defined by the number of recent days of cannabis use, with an acknowledgment that ...


The Yersinia Pestis Effector Yopm Inhibits Pyrin Inflammasome Activation., Dmitry Ratner, M Pontus A Orning, Megan K. Proulx, Donghai Wang, Mikhail A. Gavrilin, Mark D. Wewers, Emad S. Alnemri, Peter F. Johnson, Bettina Lee, Joan Mecsas, Nobuhiko Kayagaki, Jon D. Goguen, Egil Lien 2016 UMass Medical School

The Yersinia Pestis Effector Yopm Inhibits Pyrin Inflammasome Activation., Dmitry Ratner, M Pontus A Orning, Megan K. Proulx, Donghai Wang, Mikhail A. Gavrilin, Mark D. Wewers, Emad S. Alnemri, Peter F. Johnson, Bettina Lee, Joan Mecsas, Nobuhiko Kayagaki, Jon D. Goguen, Egil Lien

Department of Biochemistry and Molecular Biology Faculty Papers

Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling. To counter this, innate immune responses can also sense some T3SS components to initiate anti-bacterial mechanisms. The Yersinia pestis T3SS is particularly effective and sophisticated in manipulating the production of pro-inflammatory cytokines IL-1β and IL-18, which are typically processed into their mature forms by active caspase-1 following inflammasome formation. Some effectors, like Y. pestis YopM, may block inflammasome activation. Here we show that YopM prevents Y. pestis induced activation of the Pyrin inflammasome induced ...


Genome Research And Traditional Intellectual Property Protection -- A Bad Fit?, Kate H. Murashige 2016 University of New Hampshire

Genome Research And Traditional Intellectual Property Protection -- A Bad Fit?, Kate H. Murashige

RISK: Health, Safety & Environment

Dr. Murashige addresses the need for a patent system more closely tailored to the needs of biotechnology. For example, the obviousness requirement may interfere with using patents to recoup high costs of work when it could arguably be done by researchers of ordinary skill.


Social Issues Of Genome Innovation And Intellectual Property, Elaine Alma Draper 2016 University of New Hampshire

Social Issues Of Genome Innovation And Intellectual Property, Elaine Alma Draper

RISK: Health, Safety & Environment

Dr. Draper's focus is the use of personal information derived from genome research. She identifies several potential problems, including access to and control of genetic information, employment discrimination and social stratification. She also recommends possible solutions.


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