Marshall University
Edith Cowan University
University of Kentucky
University of North Texas Health Science Center at Fort Worth
East Tennessee State University
Thomas Jefferson University
Otterbein University
University of Dayton
University of Pennsylvania
Virulence Regulation In Pseudomonas Aeruginosa Via The Alginate Regulators, Algu And Algr, The Posttranscriptional Regulator, Rsma, And The Two-Component System, Algz/R,
2018
East Tennessee State Universtiy
Virulence Regulation In Pseudomonas Aeruginosa Via The Alginate Regulators, Algu And Algr, The Posttranscriptional Regulator, Rsma, And The Two-Component System, Algz/R, Sean Stacey
Electronic Theses and Dissertations
Pseudomonas aeruginosa is a Gram-negative bacillus able to colonize a wide variety of environments. In the human host, P. aeruginosa can establish an acute infection or persist and create a chronic infection. P. aeruginosa is able to establish a niche and persist in human hosts by using a wide array of virulence factors used for: movement, killing host cells, and evading immune cells and antibiotics. Understanding virulence factors and their regulation has proved to be an important means of combating the morbidity and mortality of P. aeruginosa as well as the ever-increasing threat of drug resistance. By targeting virulence factors ...
A Mathematical Model Of The Inflammatory Response To Pathogen Challenge,
2018
University of Richmond
A Mathematical Model Of The Inflammatory Response To Pathogen Challenge, Lester Caudill, Fiona Lynch
Annual Symposium on Biomathematics and Ecology: Education and Research
No abstract provided.
How Concussions Alter Brain Network Properties: Towards Better Diagnoses Of Concussions,
2018
University of Richmond
How Concussions Alter Brain Network Properties: Towards Better Diagnoses Of Concussions, Sara Krehbiel, Joanna R. Wares
Annual Symposium on Biomathematics and Ecology: Education and Research
No abstract provided.
Introducing The Fractional Differentiation For Clinical Data-Justified Prostate Cancer Modelling Under Iad Therapy,
2018
Illinois State University
Introducing The Fractional Differentiation For Clinical Data-Justified Prostate Cancer Modelling Under Iad Therapy, Ozlem Ozturk Mizrak
Annual Symposium on Biomathematics and Ecology: Education and Research
No abstract provided.
Using Pair Approximation Methods To Analyze Behavior Of A Probabilistic Cellular Automaton Model For Intracellular Cardiac Calcium Dynamics,
2018
Loyola Marymount University
Using Pair Approximation Methods To Analyze Behavior Of A Probabilistic Cellular Automaton Model For Intracellular Cardiac Calcium Dynamics, Robert J. Rovetti
Annual Symposium on Biomathematics and Ecology: Education and Research
No abstract provided.
Modeling An Anthrax Plume: Prioritizing The Delivery Of Antibiotics After An Anthrax Bioterrorism Event,
2018
University of Illinois at Urbana-Champaign
Modeling An Anthrax Plume: Prioritizing The Delivery Of Antibiotics After An Anthrax Bioterrorism Event, Devin Akman
Annual Symposium on Biomathematics and Ecology: Education and Research
No abstract provided.
Prothrombin Complex Concentrates Or Recombinant Factor Viia Are More Effective Than Fresh-Frozen Plasma At Lowering Inr In Patients With Liver Disease,
2018
Wayne State University
Prothrombin Complex Concentrates Or Recombinant Factor Viia Are More Effective Than Fresh-Frozen Plasma At Lowering Inr In Patients With Liver Disease, Abel J. Ignatius
Clinical Research in Practice: The Journal of Team Hippocrates
A critical appraisal and clinical application of Kwon JO, MacLaren R. Comparison of fresh-frozen plasma, four-factor prothrombin complex concentrates, and recombinant factor VIIa to facilitate procedures in critically ill patients with coagulopathy from liver disease: a retrospective cohort study. Pharmacotherapy. 2016;36(10):1047-1054. doi: 10.1002/phar.1827
Scientific, Paranormal, And Spiritual Frames In Alternative Medicine,
2018
Gettysburg College
Scientific, Paranormal, And Spiritual Frames In Alternative Medicine, Charles F. Emmons
Friday Forum
Although the term “integrative medicine” is being used to refer to the merging of complementary and alternative medicine (CAM) with standard biomedicine, there are some spiritual and paranormal frames for alternative medicine that are only partially integrated into standard medicine if at all. This study examines the orientations of some alternative practitioners and clients/users in the U.S. and the UK in terms of their views of science, spirituality and the paranormal.
Neurohype And The Law: A Cautionary Tale,
2018
University of Pennsylvania Law School
Neurohype And The Law: A Cautionary Tale, Stephen J. Morse
Faculty Scholarship
This chapter suggests that for conceptual, empirical, and practical reasons, neuroscience in general and non-invasive brain imaging in particular are not likely to revolutionize the law and our conception of ourselves, but may make modest contributions to legal policy and case adjudication if the legal relevance of the science is properly understood.
Resting-State Functional Connectivity In Youth With Gender Dysphoria,
2018
The Graduate Center, City University of New York
Resting-State Functional Connectivity In Youth With Gender Dysphoria, Felix L. Garcia
All Dissertations, Theses, and Capstone Projects
Current developmental models of gender identity and gender dysphoria (GD) lack sex-specific profiles of brain function that differentiate between typically-developing and cross-gender identified youth, as postulated by models like the unified theory of the origins of sex differences (Arnold, 2009) and the neurobiological theory of the origins of transsexuality (Swaab & Garcia-Falgueras, 2009). Previously, investigators have used brain imaging modalities such as Resting-State functional Magnetic Resonance Imaging (R-fMRI) to demonstrate differences in resting-state functional connectivity (RSFC) between typically-developing male and female youth, and between typically-developing and GID-diagnosed youth. In the present pilot study, I used R-fMRI to investigate differences in RSFC between typically-developing and cross-gender identified male and female youth subgroups, with the hypothesis that GID-diagnosed subgroups would demonstrate connectivity patterns in between those of typically-developing males and females. Eleven youth diagnosed with gender identity disorder (four males, ages 9 to 20 years; seven females, ages 12 to 20 years) were matched on age and assigned gender with 11 typically-developing youth. All participants completed written informed consent to undergo the IRB-approved research procedures. R-fMRI were collected while the participants were lying down and resting, with their eyes closed. Primary analyses focused on 14 ...
Listeria Monocytogenes As A Vector For Cancer Immunotherapy: Current Understanding And Progress,
2018
Thomas Jefferson University
Listeria Monocytogenes As A Vector For Cancer Immunotherapy: Current Understanding And Progress, John C. Flickinger, Ulrich Rodeck, Adam E. Snook
Department of Pharmacology and Experimental Therapeutics Faculty Papers
Listeria monocytogenes, a Gram-positive facultative anaerobic bacterium, is becoming a popular vector for cancer immunotherapy. Indeed, multiple vaccines have been developed utilizing modified Listeria as a tool for generating immune responses against a variety of cancers. Moreover, over a dozen clinical trials testing Listeria cancer vaccines are currently underway, which will help to understand the utility of Listeria vaccines in cancer immunotherapy. This review aims to summarize current views on how Listeria-based vaccines induce potent antitumor immunity and the current state of Listeria-based cancer vaccines in clinical trials. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Relapsed Ovarian High-Grade Serous Carcinoma With Long-Term Survival Associated With Synchronous Primary Squamous Cell Carcinoma Of The Colon,
2018
School of Medicine University of Rijeka, University of Rijeka, Croatia
Relapsed Ovarian High-Grade Serous Carcinoma With Long-Term Survival Associated With Synchronous Primary Squamous Cell Carcinoma Of The Colon, Karla Sladoljev, Ena Perin, Ani Mihaljević Ferrari, Marko Klarić, Alemka Brnčić-Fischer, Senija Eminović, Danijela Vrdoljak-Mozetič, Emina Babarovic
Proceedings in Obstetrics and Gynecology
High-grade serous ovarian cancer (HGSOC) is the most common and also the most aggressive subtype of ovarian cancer while squamous cell carcinoma (SCC) of the colon is an extremely rare histologic subtype of all colonic malignancies with poor prognosis.
Here we report a unique case of synchronous primary SCC of the colon and second recurrence of HGSOC in a patient with 15-years survival. Our patient developed two recurrent HGSOCs with disease-free survival time of five and nine years, respectively. The second recurrence of HGSOC was associated with the synchronous primary SCC of the ascending colon and was further complicated with ...
Distinct Neuropsychological Profile And Associated Neurochemical Changes In Individuals With Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes (Melas),
2018
The Graduate Center, City University of New York
Distinct Neuropsychological Profile And Associated Neurochemical Changes In Individuals With Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes (Melas), Emily B. Leaffer
All Dissertations, Theses, and Capstone Projects
Background: Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS) is a maternally inherited progressive multisystemic disorder. Occurrence of seizure and/or stroke-like episode, as well as classic biomarkers (i.e., cerebral lactic acidosis, depleted N-acetylaspartate (NAA)), have been linked to neuropsychological deficit and trigger the developmental cascade of neurodegeneration affecting posterior prior to anterior brain regions. While a pattern of global deterioration has been reported, systematic examination in a large MELAS cohort has not been conducted.
Objective: First, we examined verbal and visual memory function and its relationship to brain metabolites (lactate, NAA) in individuals with MELAS. Second, we hypothesized ...
Atherosclerosis In Subjects Newly Diagnosed With Human Immunodeficiency Virus Infection.,
2018
George Washington University
Atherosclerosis In Subjects Newly Diagnosed With Human Immunodeficiency Virus Infection., Tatiana V Kirichenko, Veronika A Myasoedova, Tatiana E Shimonova, Alexandra A Melnichenko, Dmitri Sviridov, Igor A Sobenin, Alexey I Mazus, Alexander N Orekhov, Michael I Bukrinsky
Microbiology, Immunology, and Tropical Medicine Faculty Publications
HIV infection is associated with the increased risk of cardiovascular disease (CVD), even in patients successfully treated with the combination antiretroviral therapy (cART). However, the relationship between HIV, cART, and pathogenesis of CVD remains controversial. In the present study, we evaluated the carotid intima-media thickness (CIMT), a surrogate marker of atherosclerosis, in HIV-infected subjects receiving or not receiving cART. One hundred nine newly diagnosed HIV-infected subjects and one hundred nine uninfected age-matched controls (all males) without the history of CVD, hypertension, or diabetes were recruited into the present study. Cross-sectional analysis at baseline (BL) showed significantly increased levels of triglycerides ...
Coping With Chronic Fungal Rhinosinusitis: Diagnosis To Therapy,
2018
University of Louisville
Coping With Chronic Fungal Rhinosinusitis: Diagnosis To Therapy, Veronica Corcino, Leslie Beavin, Shengli Lu, Ashley Ross, Carmen V. Sciortino Jr.
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Recombinant Human Proteoglycan-4 Reduces Phagocytosis Of Urate Crystals And Downstream Nuclear Factor Kappa B And Inflammasome Activation And Production Of Cytokines And Chemokines In Human And Murine Macrophages,
2018
Chapman University
Recombinant Human Proteoglycan-4 Reduces Phagocytosis Of Urate Crystals And Downstream Nuclear Factor Kappa B And Inflammasome Activation And Production Of Cytokines And Chemokines In Human And Murine Macrophages, Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Wendy Wong, Anthony M. Reginato, Changqi Sun, Tannin A. Schmidt
Pharmacy Faculty Articles and Research
Microbial biofilms are organized communities of cells that are associated with a wide spectrum of resistant and chronic infections that lead to the treatment failure. Accordingly, there is an urgent demand to create novel effective therapeutic drugs that can inhibit biofilm formation with new mechanisms of action to surmount the current escalating resistance. In this study, in silico hybrid model was utilized to develop three novel short linear peptides (4, 5, and 6) with potential biofilm inhibiting activities (scores > 1.0). The peptides were composed of cationic and hydrophobic residues. They were synthesized using solid-phase strategy. Synthesized peptides were purified ...
The Epidemiology Of Infective Endocarditis Among People Who Inject Drugs In London, Ontario.,
2018
The University of Western Ontario
The Epidemiology Of Infective Endocarditis Among People Who Inject Drugs In London, Ontario., Brian Hallam
Electronic Thesis and Dissertation Repository
Infective endocarditis is an infectious disease that affects the valves of the heart. Injection drug use is currently a leading risk factor among patients with endocarditis. We conducted a prospective study using data from hospital chart records among patients with endocarditis in London, Ontario, which has a relatively high prevalence of people who inject drugs to assess the severity of the issue and the major risk factors of mortality pertaining to this population. This study had a sample size of 353 and included a review of the incidence of admissions of endocarditis, as well as a survival analysis, using both ...
Lafora Disease Masquerading As Hepatic Dysfunction,
2018
Allama Iqbal Medical College
Lafora Disease Masquerading As Hepatic Dysfunction, Faisal Inayat, Waqas Ullah, Hanan T. Lodhi, Zarak H. Khan, Ghulam Ilyas, Nouman Safdar Ali, Hafez Mohammad A. Abdullah
Abington Hospital Papers
Lafora disease is fatal intractable progressive myoclonic epilepsy. It is frequently characterized by epileptic seizures, difficulty walking, muscle spasms, and dementia in late childhood or adolescence. We chronicle here an unusual case of an asymptomatic young male soccer player who presented with elevated liver enzymes. Neurological examination was unremarkable. The diagnostic workup for hepatitis, infectious etiologies, autoimmune disorders, hemochromatosis, Wilson's disease, alpha-1 antitrypsin deficiency, and other related diseases was inconclusive. He subsequently underwent an uneventful percutaneous liver biopsy. Based on the pathognomonic histopathological findings, Lafora disease was considered the likely etiology. The present study is a unique illustration of ...
Fatigue Associated With Rheumatoid Arthritis In Young Adults,
2018
DePaul University
Fatigue Associated With Rheumatoid Arthritis In Young Adults, Sydney Van Alstyne
Grace Peterson Nursing Research Colloquium
Background: Often, practitioners do not address their Rheumatoid Arthritis patients' fatigue and do not perceive it as a detriment to the patient's wellness. In actuality, fatigue has been determined to be proportionate to the other variables, such as pain and disease progression, of rheumatoid arthritis.
Objectives: to determine the cause(s) of fatigue in rheumatoid arthritis and determine how fatigue can be used in a clinical setting to determine disease progression and status in patients suffering from chronic illness.
Method: This integrative literature review was conducted using the keywords, “fatigue, rheumatoid arthritis, young adults, perception of fatigue” to search ...
Attenuation Of Na/K-Atpase Mediated Oxidant Amplification With Pnaktide Ameliorates Experimental Uremic Cardiomyopathy,
2018
Marshall University
Attenuation Of Na/K-Atpase Mediated Oxidant Amplification With Pnaktide Ameliorates Experimental Uremic Cardiomyopathy, Jiang Liu, Jiang Tian, Muhammad Chaudhry, Kyle Maxwell, Yanling Yan, Xiaoliang Wang, Preeya T. Shah, Asad A. Khawaja, Rebecca Martin, Tylor J. Robinette, Adee El-Hamdani, Michael W. Dodrill, Komal Sodhi, Christopher A. Drummond, Steven T. Haller, David J. Keenedy, Nader G. Abraham, Zijian Xie, Joseph I. Shapiro Md
Nader G. Abraham
We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In this study, we examined whether attenuation of oxidant stress by antagonism of Na/K-ATPase oxidant amplification might ameliorate experimental uremic cardiomyopathy induced by partial nephrectomy (PNx). PNx induced the development of cardiac morphological and biochemical changes consistent with human uremic cardiomyopathy. Both inhibition of Na/K-ATPase oxidant amplification with pNaKtide and induction of heme oxygenase-1 (HO-1) with cobalt protoporphyrin (CoPP) markedly attenuated the development of phenotypical features of uremic cardiomyopathy. In a reversal study, administration of pNaKtide after the ...
