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Fronto-Parietal And Cingulo-Opercular Network Integrity And Global Cognition In Health And Schizophrenia, Julia May Sheffield 2014 Washington University in St. Louis

Fronto-Parietal And Cingulo-Opercular Network Integrity And Global Cognition In Health And Schizophrenia, Julia May Sheffield

Arts & Sciences Electronic Theses and Dissertations

Growing evidence suggests that coordinated activity within specific functional brain networks supports cognitive ability, and that abnormalities in brain connectivity may underlie cognitive deficits observed in neuropsychiatric diseases, such as schizophrenia. Two functional networks, the fronto-parietal network (FPN) and cingulo-opercular network (CON), are hypothesized to support top-down control of executive functioning, and have therefore emerged as potential drivers of cognitive impairment in disease-states. Application of graph theory analysis to functional connectivity data provides characterizations of network topology, allowing for the analysis of relationships between cognitive ability and network integrity. In the current study we applied graph analysis to pseudo-resting state ...


Validating Hemoglobin Saturation And Dissolved Oxygen In Tumors Using The Oxylab Probe And Photoacoustic Imaging, Jenna Burnett, Justin Sick, MS, Marc Mendonca, Keith Stantz, PhD 2014 Purdue University

Validating Hemoglobin Saturation And Dissolved Oxygen In Tumors Using The Oxylab Probe And Photoacoustic Imaging, Jenna Burnett, Justin Sick, Ms, Marc Mendonca, Keith Stantz, Phd

The Summer Undergraduate Research Fellowship (SURF) Symposium

The goal of this experiment is to validate the relationship between hemoglobin saturation (SaO2) and partial pressure of dissolved oxygen (pO2) in breast tumors in mice using photoacoustic computed tomographic (PCT) imaging and OxyLite probe, respectively. In its simplest form, the relationship is described by the dissociation curve, or Hill’s equation, for hemoglobin, and is modeled as a sigmoidal curve that is a function of two parameters – the Hill coefficient, n, and the net association constant of HbO2, K (or pO2 at 50% SaO2). First, a calibration study to validate Hill’s equation in ...


Stratified Meta-Analysis To Examine Data Biases In Lung Cancer Studies Of Refinery Workers, Sherman Selix 2014 Yale University

Stratified Meta-Analysis To Examine Data Biases In Lung Cancer Studies Of Refinery Workers, Sherman Selix

Yale Day of Data

Petroleum refineries employ a variety of workers who historically experienced different potentials for asbestos exposure depending on job tasks. Associations between petroleum refinery work and lung cancer related to occupational asbestos exposure have been quantified among various locations, corporations, and time periods. To combine the data from several individual refinery studies and examine an overall effect, a systematic review and stratified meta-analysis was employed. Using set search terms among four databases, 112 potential publications were identified, of which 29 qualified for meta-analysis. Risk estimates and confidence intervals were extracted from these publications to construct four separate datasets. Inverse variance weighting ...


Genetic Genealogy: What Every Librarian Should Know, Katherine A. Pennavaria, Rosemary L. Meszaros 2014 Western Kentucky University

Genetic Genealogy: What Every Librarian Should Know, Katherine A. Pennavaria, Rosemary L. Meszaros

Rosemary L. Meszaros

The past few years television, podcasts, and blogs across the Internet promoted the role of DNA testing in genealogy. But what do you really get, and is it worth the price? We discuss the logistics of DNA testing as it relates to genealogy and take a hard look at the legal issues involved in genealogy’s hottest topic.


Perampanel Inhibition Of Ampa Receptor Currents In Cultured Hippocampal Neurons, Chao-Yin Chen, Lucas Matt, Johannes Wilhelm Hell, Michael A. Rogawski 2014 SelectedWorks

Perampanel Inhibition Of Ampa Receptor Currents In Cultured Hippocampal Neurons, Chao-Yin Chen, Lucas Matt, Johannes Wilhelm Hell, Michael A. Rogawski

Michael A. Rogawski

Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized. Here the action of perampanel on AMPA receptors was investigated by whole-cell voltage-clamp recording in cultured rat hippocampal neurons. Perampanel caused a slow (τ~1 s at 3 µM), concentration-dependent inhibition of AMPA receptor currents evoked by AMPA and kainate. The rates of block and unblock of AMPA receptor currents were 1.5×105 M−1 s−1 and 0.58 s−1, respectively. Perampanel did ...


Differential Spatial Repositioning Of Activated Genes In Biomphalaria Glabrata Snails Infected With Schistosoma Mansoni, Halime D. Arican-Goktas, Wannaporn Ittiprasert, Joanna M. Bridger, Matty Knight 2014 Himmelfarb Health Sciences Library, The George Washington University

Differential Spatial Repositioning Of Activated Genes In Biomphalaria Glabrata Snails Infected With Schistosoma Mansoni, Halime D. Arican-Goktas, Wannaporn Ittiprasert, Joanna M. Bridger, Matty Knight

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Schistosomiasis is an infectious disease infecting mammals as the definitive host and fresh water snails as the intermediate host. Understanding the molecular and biochemical relationship between the causative schistosome parasite and its hosts will be key to understanding and ultimately treating and/or eradicating the disease. There is increasing evidence that pathogens that have co-evolved with their hosts can manipulate their hosts' behaviour at various levels to augment an infection. Bacteria, for example, can induce beneficial chromatin remodelling of the host genome. We have previously shown in vitro thatBiomphalaria glabrata embryonic cells co-cultured with schistosome miracidia display genes changing ...


2014 Scas Annual Meeting Program, 2014 University of South Carolina

2014 Scas Annual Meeting Program

Journal of the South Carolina Academy of Science

No abstract provided.


Genotypic And Phenotypic Characterization Of Aerosolized Bacteria Collected From African Dust Events, Christina A. Wilson, Robin L. Brigmon, Chris Yeager, Garriet W. Smith, Shawn W. Polson 2014 University of South Carolina

Genotypic And Phenotypic Characterization Of Aerosolized Bacteria Collected From African Dust Events, Christina A. Wilson, Robin L. Brigmon, Chris Yeager, Garriet W. Smith, Shawn W. Polson

Journal of the South Carolina Academy of Science

Twenty-one bacteria were isolated and characterized from air samples collected in Africa and the Caribbean by the United States Geological Survey (USGS). Isolates were selected based on preliminary characterization as possible pathogens. Identification of the bacterial isolates was achieved using 16S rRNA gene sequence analysis, fatty acid methyl esters (FAMEs) profiling, the BIOLOG Microlog® System (carbon substrate assay), and repetitive extragenic palindromic (REP)-PCR analysis. The majority of isolates (18/21) were identified as species of the genus Bacillus. Three isolates were classified within the Bacillus cereus senso lato group, which includes Bacillus anthracis, Bacillus thuringiensis, and Bacillus cereus strains ...


Remembering To Perform Actions In The Future: Can Intentions Pop Into Mind?, Gilles O. Einstein 2014 University of South Carolina

Remembering To Perform Actions In The Future: Can Intentions Pop Into Mind?, Gilles O. Einstein

Journal of the South Carolina Academy of Science

No abstract provided.


Role Of Vitamin A In Retinal Diseases, Rosalie K. Crouch, Masahiro Kono, Peter H. Tang 2014 University of South Carolina

Role Of Vitamin A In Retinal Diseases, Rosalie K. Crouch, Masahiro Kono, Peter H. Tang

Journal of the South Carolina Academy of Science

Vitamin A has an essential role in vision in that it forms the photosensitive pigments that absorb light and initiate the visual process. However, vitamin A and its analogues also have critical roles in maintaining the structural integrity of the retina. Disruption of the metabolism of vitamin A results in several blinding diseases. This review focuses on our recent studies on the role of a protein critical to the processing of vitamin A, RPE65. The absence or dysfunction of this protein causes the childhood blinding disease Leber congenital amaurosis.


Scas Officers And Council Members 2014-2015, 2014 University of South Carolina

Scas Officers And Council Members 2014-2015

Journal of the South Carolina Academy of Science

No abstract provided.


Table Of Contents, 2014 University of South Carolina

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.


Selection Of An Eevolved Orthogonal Ne-Acetyllysine Trnasynthetase That Can Incorporate The Unnantural Amino Acid L-Homocitrulline Site-Specifically Into Proteins, Jaclyn Alatrash, Camelia Baleanu Gogonea, Stanly L. Hazen, Joseph DiDonato 2014 Cleveland State University

Selection Of An Eevolved Orthogonal Ne-Acetyllysine Trnasynthetase That Can Incorporate The Unnantural Amino Acid L-Homocitrulline Site-Specifically Into Proteins, Jaclyn Alatrash, Camelia Baleanu Gogonea, Stanly L. Hazen, Joseph Didonato

Undergraduate Research Posters 2014

Oxidatively damaged apolipoprotein A1 (apoA1, the main protein constituent of high density lipoprotein (HDL) - the “good cholesterol”) has been isolated from circulating plasma and atherosclerosis plaque with modification of lysine amino acid residues to homocittruline (carbamyllysine) in apoA1 identified as a modification found increased in smokers that correlates with elevated cardiovascular risk for myocardial infarction (MI), stoke or death. The selected carbamyllysine tRNA synthetase will then be used to express a series of human apoA1 alleles containing amber codons in place of various lysine residues and assayed for its ability to form nascent HDL particles and to activate NF-κB and ...


Fabrication And Characterization Of Cell Membrane, Ali Naserallah, Valentinas Gruzdys, Xue-Long Sun 2014 Cleveland State University

Fabrication And Characterization Of Cell Membrane, Ali Naserallah, Valentinas Gruzdys, Xue-Long Sun

Undergraduate Research Posters 2014

Cell membrane plays critical cellular functions in both physiological and pathological pathways and thus is important target for both basic and applied biomedical research. The domain structure features of cell membrane strongly affect the functions of membrane embedded biomolecules such as proteins and carbohydrates. However, understanding the structural aspects of membrane effects on the embedded biomolecule’s function have not been able easily to do due to limited approaches available. We have engaged in fabrication of cell membrane mimetic systems for functional analysis of membrane proteins and cell surface carbohydrates [1,2]. Thrombomodulin (TM), an endothelial integral membrane protein, plays ...


The Use Of Elastin-Like Polypeptides As A Drug Carrier Material: A Compatibility Study, Michael G. Price, John P. Gavin, Eric Helm, James T. Cole, Nolan Holland 2014 Cleveland State University

The Use Of Elastin-Like Polypeptides As A Drug Carrier Material: A Compatibility Study, Michael G. Price, John P. Gavin, Eric Helm, James T. Cole, Nolan Holland

Undergraduate Research Posters 2014

Stimuli responsive self-assembling nanoparticles of elastin-like polypeptides are promising platforms for targeted drug delivery and release. These particles spontaneously assemble from elastin-like polypeptide building blocks in solution. The nanoparticles stably self-assemble under specific temperature, salt, and pH conditions and can dissociate upon changing of these conditions. With appropriate design, the surface of the particles can be decorated with labels that cause them to accumulate in specific diseased tissues. In addition, the size of the particles is appropriate to minimize undesirable rapid clearance from the body. In this study, we are testing the ability of the elastin-like polypeptide core to store ...


Cell Death Regulates Injury And Inflammation During Renal Allograft Transplantation, Arthur Lau 2014 Western University

Cell Death Regulates Injury And Inflammation During Renal Allograft Transplantation, Arthur Lau

University of Western Ontario - Electronic Thesis and Dissertation Repository

Renal transplantation invariably results in tissue injury resulting from ischemia reperfusion injury (IRI), inflammation, drug toxicity, and rejection. Tubular epithelial cells (TEC) comprise the majority of renal parenchyma and are susceptible to cell death and injury during diverse forms of inflammation, which has direct and indirect effects on long term allograft function. Renal TEC have the unique ability to attenuate inflammation and alloimmune injury through the expression of various mediators of cell death and inflammatory molecules. Inhibition of cell death pathways in renal allografts may influence outcomes of alloimmune responses and graft survival. In this body of investigation, alteration of ...


Implementation And Validation Of Aortic Remodeling In Hypertensive Rats, Shijia Zhao, Linxia Gu 2014 University of Nebraska - Lincoln

Implementation And Validation Of Aortic Remodeling In Hypertensive Rats, Shijia Zhao, Linxia Gu

Mechanical & Materials Engineering Faculty Publications

A computational framework was implemented and validated to better understand the hypertensive artery remodeling in both geometric dimensions and material properties. Integrating the stress-modulated remodeling equations into commercial finite element codes allows a better control and visualization of local mechanical parameters. Both arterial thickening and stiffening effects were captured and visualized. An adaptive material remodeling strategy combined with the element birth and death techniques for the geometrical growth were implemented. The numerically predicted remodeling results in terms of the wall thickness, inner diameter, and the ratio of elastin to collagen content of the artery were compared with and fine-tuned by ...


Assessment Of Resident And Faculty Preferences For Clinical Pharmacy Services Within A Developing Family Medicine Residency Program, Kerry Haney 2014 University of Montana

Assessment Of Resident And Faculty Preferences For Clinical Pharmacy Services Within A Developing Family Medicine Residency Program, Kerry Haney

University Grant Program Reports

No abstract provided.


Regulation Of Metabotropic Glutamate Receptor 5 Activity By Ca2+/Calmodulin-Dependent Protein Kinase Iiα, Fitore Raka 2014 Western University

Regulation Of Metabotropic Glutamate Receptor 5 Activity By Ca2+/Calmodulin-Dependent Protein Kinase Iiα, Fitore Raka

University of Western Ontario - Electronic Thesis and Dissertation Repository

The metabotropic glutamate receptor 5 (mGluR5) is a GPCR coupled to the heterotrimeric G protein Gaq/11 and activates signaling pathways important for excitatory synaptic transmission. Emerging studies reveal that Amyloid b (Ab) acts as an extracellular scaffold for mGluR5. We have identified Ca2+/Calmodulin-dependent protein Kinase IIα (CAMKIIα) as an interacting protein of mGluR5. We hypothesize that CaMKIIα plays a role in mGluR5 signaling and Ab produces differential effects on the regulation of mGluR5 by CAMKIIα. We find that overexpression of CAMKIIα significantly impairs mGluR5-mediated ERK1/2 phosphorylation but does not effect inositol phosphate formation or Ca ...


Pedigree Structure And Kinship Measurements Of A Mid-Michigan Community: A New North American Population Isolate Identified, Joseph D. Bonner, Rachel Fisher, James Klein, Qing Lu, Ellen Wilch, Karen H. Friderici, Jill L. Elfenbein, Debra L. Schutte, Brian C. Schutte 2014 Wayne State University

Pedigree Structure And Kinship Measurements Of A Mid-Michigan Community: A New North American Population Isolate Identified, Joseph D. Bonner, Rachel Fisher, James Klein, Qing Lu, Ellen Wilch, Karen H. Friderici, Jill L. Elfenbein, Debra L. Schutte, Brian C. Schutte

Human Biology Open Access Pre-Prints

Previous studies identified a cluster of individuals with an autosomal recessive form of deafness that resides in a small region of mid-Michigan. We hypothesized that affected members from this community descend from a defined founder population. Using public records and personal interviews, we constructed a genealogical database that includes the affected individuals and their extended families as descendants of 461 settlers who emigrated from the Eifel region of Germany between 1836 and 1875. The genealogical database represents a 13-generation pedigree that includes 27,747 descendants of these settlers. Among these descendants, 13,784 are presumed living. Many of the extant ...


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