Biochemical Phenomena, Metabolism, and Nutrition Commons™
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Recent Articles in Biochemical Phenomena, Metabolism, and Nutrition
Novel Therapeutic Targets Identified By High-Throughput Technologies For Triple-Negative Breast Cancer, Christine Shiang 
Texas Medical Center Library
Novel Therapeutic Targets Identified By High-Throughput Technologies For Triple-Negative Breast Cancer, Christine Shiang
UT GSBS Dissertations and Theses (Open Access)
Triple-negative breast cancers (TNBC) are characterized by the lack of or reduced expression of the estrogen and progesterone receptors, and normal expression of the human epidermal growth factor receptor 2. The lack of a well-characterized target for treatment leaves only systemic chemotherapy as the mainstay of treatment. Approximately 60-70% of patients are chemosensitive, while the remaining majority does not respond. Targeted therapies that take advantage of the unique molecular perturbations found in triple-negative breast cancer are needed. The genes that are frequently amplified or overexpressed represent potential therapeutic targets for triple-negative breast cancer. The purpose of this study was to ...
Age-Dependent Decrease And Alternative Splicing Of Methionine Synthase Mrna In Human Cerebral Cortex And An Accelerated Decrease In Autism, Christina R. Muratore, Nathaniel W. Hodgson, Malav S. Trivedi, Hamid M. Abdolmaleky, Antonio M. Persico, Carla Lintas, Suzanne De La Monte, Richard C. Deth 
Northeastern University
Age-Dependent Decrease And Alternative Splicing Of Methionine Synthase Mrna In Human Cerebral Cortex And An Accelerated Decrease In Autism, Christina R. Muratore, Nathaniel W. Hodgson, Malav S. Trivedi, Hamid M. Abdolmaleky, Antonio M. Persico, Carla Lintas, Suzanne De La Monte, Richard C. Deth
Bouvé Faculty Publications
The folate and vitamin B12-dependent enzyme methionine synthase (MS) is highly sensitive to cellular oxidative status, and lower MS activity increases production of the antioxidant glutathione, while simultaneously decreasing more than 200 methylation reactions, broadly affecting metabolic activity. MS mRNA levels in postmortem human cortex from subjects across the lifespan were measured and a dramatic progressive biphasic decrease of more than 400-fold from 28 weeks of gestation to 84 years was observed. Further analysis revealed alternative splicing of MS mRNA, including deletion of folate-binding domain exons and age-dependent deletion of exons from the cap domain, which protects vitamin B12 (cobalamin ...
Glucose Supplementation And Measures Of Oxidative Stress In Patients With Glycogen Phosphorylase Deficiency (Mcardle’S Disease)., Nicholas Joseph Mocellin 
McMaster University
Glucose Supplementation And Measures Of Oxidative Stress In Patients With Glycogen Phosphorylase Deficiency (Mcardle’S Disease)., Nicholas Joseph Mocellin
Open Access Dissertations and Theses
Objective: We evaluated the potential effect of oral glucose supplementation on: (1) exercise performance and tolerance, (2) the concentrations of plasma uric acid and ammonia (NH3) and (3) blood plasma markers of oxidative stress in patients with McArdle’s disease (MCD) after non-ischemic forearm exercise testing (non-ischemic forearm exercise test). Methods: Blood samples and exercise performance measures were performed on from 16 patients with MCD and 17 control subjects (CON) matched for age, sex and physical activity status. Subjects performed 2 exercise bouts 30 minutes apart and received oral glucose or placebo supplementation between tests. Blood samples were analyzed ...
The Role Of Srebp-1 In Mediating Angiotensin Ii- Induced Kidney Fibrosis, Nuo Wang McMaster University
The Role Of Srebp-1 In Mediating Angiotensin Ii- Induced Kidney Fibrosis, Nuo Wang
Open Access Dissertations and Theses
End stage renal disease (ESRD) has been a world-wide cause of renal disease-related fatality. Most patients with ESRD progress through chronic kidney disease (CKD). There are various causes of CKD including mechanical stress, infections, high blood pressure or immune conditions. Renal fibrosis is known to play an important pathogenic role in CKD and ESRD. Transforming growth factor-beta (TGF-ß) is one of the major mediators of fibrosis, and inhibition of TGF-ß could reduce renal fibrosis in in vitro models. One of the well - known inducers of TGF-ß transcr iption is Angiotensin II (ANGII). 1 This is a major contributor to the ...
The New Role Of Proprotein Convertase Subtilisin/Kexin Type 9: A Connection Of Proprotein Convertase Subtilisin/Kexin Type 9, Apolipoprotein B, And Autophagy, Hua Sun Texas Medical Center Library
The New Role Of Proprotein Convertase Subtilisin/Kexin Type 9: A Connection Of Proprotein Convertase Subtilisin/Kexin Type 9, Apolipoprotein B, And Autophagy, Hua Sun
UT GSBS Dissertations and Theses (Open Access)
Plasma low-density lipoprotein (LDL) levels are positively correlated with the incidence of coronary artery disease. In the circulation, the plasma LDL clearance is mainly achieved by the uptake via LDL receptor (LDLR). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a newly discovered gene, playing an important role in LDL metabolism. Gain-of-function mutations of PCSK9 lead to hypercholesterolemia and loss-of-function mutations of PCSK9 are associated with decrease of LDL cholesterol. The effects of PCSK9 on cholesterol levels are the consequence of a strong interaction between the catalytic domain of PCSK9 and epidermal growth factor-like repeat A (EGF-A) domain of LDLR ...
Popular Institutions
Popular Authors
Jennifer Swick
University of Massachusetts - Amherst
W. Hardman
Marshall University
Hua Sun
Texas Medical Center Library
Gabriela Ion
Marshall University
Suzanne Booker
University of Tennessee, Knoxville
Arshad Khan*
University of Texas at El Paso
Richard Deth
Northeastern University
José Rodríguez
The Florida State University
Shiraj Sen
Texas Medical Center Library
Aileen Marcelo
Marshall University
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Popular Articles
Effect Of The Flavonoid Quercetin On Adipocytes, Jennifer Swick
Synergy 2011: Annual Research Report
Suppression Of Implanted Mda-Mb 231 Human Breast Cancer Growth In Nude Mice By Dietary Walnut, W. Hardman, Gabriela Ion
Regional Differences In Adipose Tissue Of The Sinclair Minipig, Suzanne Booker
Identification And Characterization Of Novel Sir3/Mecp2-Chromatin Interactions
Synergy 2010: Annual Research Report
Mobile Health Unit For Obesity Education: Attitudes And Perceptions Among Local Homeless Residents, José Rodríguez
Metabolic Regulation Of Mtor Activation And Endoplasmic Reticulum Stress In The Heart, Shiraj Sen
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