Medical Anatomy Commons^™

Exploration Of Three-Dimensional Morphometrics Of The Hip Joint And Reconstructive Technologies, Charys M. Martin

Electronic Thesis and Dissertation Repository

This dissertation is an exploration of three-dimensional (3D) anatomy using the hip joint as the model of study. Very few studies have taken advantage of 3D modeling to assess the features of commercially available software, or to assess the validity and reliability of 3D morphometrics. This dissertation compared three reconstructive software programs to survey user appreciation concerning how 3D anatomical reconstructive software can be utilized and then established the advantages and limitations of 3D measurements in the hip joint. Three main studies are presented: the first, a comparison of three widely available 3D reconstructive software programs, Amira, OsiriX, and Mimics ...

Body Mapping With Geriatric Inpatients Receiving Daily Haemodialysis Therapy For End-Stage Renal Disease At Toronto Rehabilitation Institute: A Qualitative Study, Bryn A. Ludlow

Open Access Dissertations and Theses

The innovative research method of “body mapping” was used in this study with geriatric inpatients receiving daily hæmodialysis therapy for end-stage renal disease at Toronto Rehabilitation Institute.

Five people took part in this study; three participants completed all study phases. They created three body maps each and took part in one follow up, semi-structured interview to share their experiences of body mapping. Two themes were drawn from the data: (1) body mapping gives patients a voice to communicate their experiences in the dialysis unit; and (2) body mapping makes visible participants’ illness adjustment patterns, and levels of connection, or disconnection ...

Proline-Rich Tyrosine Kinase 2 (Pyk2) Regulates Igf-I-Induced Cell Motility And Invasion Of Urothelial Carcinoma Cells, Marco Genua, Shi-Qiong Xu, Simone Buraschi, Stephen C. Peiper, Leonard G. Gomella, Antonio Belfiore, Renato V. Iozzo, Andrea Morrione

Department of Pathology, Anatomy and Cell Biology Faculty Papers

The insulin-like growth factor receptor I (IGF-IR) plays an essential role in transformation by promoting cell growth and protecting cancer cells from apoptosis. We have recently demonstrated that the IGF-IR is overexpressed in invasive bladder cancer tissues and promotes motility and invasion of urothelial carcinoma cells. These effects require IGF-I-induced Akt- and MAPK-dependent activation of paxillin. The latter co-localizes with focal adhesion kinases (FAK) at dynamic focal adhesions and is critical for promoting motility of urothelial cancer cells. FAK and its homolog Proline-rich tyrosine kinase 2 (Pyk2) modulate paxillin activation; however, their role in regulating IGF-IR-dependent signaling and motility in ...