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B7h6: A Cancer Biomarker For The Development Of Novel Immunotherapy Approaches, Mariana Phillips 2017 Seton Hall University

B7h6: A Cancer Biomarker For The Development Of Novel Immunotherapy Approaches, Mariana Phillips

Seton Hall University Dissertations and Theses (ETDs)

Cancer-based immunotherapy has led the evolution of biologics that can stimulate immune responses towards tumor eradication. The synthesis of small to intermediate size molecules with the targeting and effector functions of mAb may represent a novel class of immunotherapeutics that may overcome the limitations of their biological counterparts.Towards this objective, B7H6 has been identified as a protein ligand localized on the cell surface of transformed tumor cells. B7H6 binds specifically to the activating receptor NKp30, constitutively expressed on all resting and active NK cells. Upon ligand:receptor binding, B7H6 triggers NK cell activation and release of chemokines and pro-inflammatory ...


Denoising Tandem Mass Spectrometry Data, Felix Offei 2017 East Tennessee State Universtiy

Denoising Tandem Mass Spectrometry Data, Felix Offei

Electronic Theses and Dissertations

Protein identification using tandem mass spectrometry (MS/MS) has proven to be an effective way to identify proteins in a biological sample. An observed spectrum is constructed from the data produced by the tandem mass spectrometer. A protein can be identified if the observed spectrum aligns with the theoretical spectrum. However, data generated by the tandem mass spectrometer are affected by errors thus making protein identification challenging in the field of proteomics. Some of these errors include wrong calibration of the instrument, instrument distortion and noise. In this thesis, we present a pre-processing method, which focuses on the removal of ...


E,E-Farnesol Inhibits Swarming Motility In Burkholderia Cepacia Through Rhamnolipid Production, Stephanie E. Nicholls, Alayna N. Sanderson, Andrea P. Schwartz, Lauren E. Ward, Jessica N. Weisensee, Molly Yandrofski, Tracy L. Collins 2017 Cedarville University

E,E-Farnesol Inhibits Swarming Motility In Burkholderia Cepacia Through Rhamnolipid Production, Stephanie E. Nicholls, Alayna N. Sanderson, Andrea P. Schwartz, Lauren E. Ward, Jessica N. Weisensee, Molly Yandrofski, Tracy L. Collins

The Research and Scholarship Symposium

Burkholderia cepacia and Candida albicans both exhibit cell-to-cell communication through the use of quorum-sensing molecules (QSM) known as autoinducers. E,E-farnesol is a QSM produced by C. albicans which regulates its conversion from yeast to mycelium. Because there is a positive correlation between the presence of B. cepacia and C. albicans in the lungs of individuals with cystic fibrosis (CF), we examined whether E,E-farnesol had an effect on swarming motility in B. cepacia. Swarming motility was inhibited when B. cepacia was exposed to 250 µM of E,E-farnesol. In addition, there was a 26.8% decrease in rhamnolipid production ...


Spatial And Temporal Variability Of Water Quality Parameters In Cedar Lake (Cedarville, Ohio), Laura A. Cashman, William A. Smith, Shannon L. Swicker, Abigail L. Williams, Mark A. Gathany 2017 Cedarville University

Spatial And Temporal Variability Of Water Quality Parameters In Cedar Lake (Cedarville, Ohio), Laura A. Cashman, William A. Smith, Shannon L. Swicker, Abigail L. Williams, Mark A. Gathany

The Research and Scholarship Symposium

Cedar Lake is a man-made lake that is central to Cedarville University’s campus. This focal point of the campus is a source of aesthetic appeal and beauty of Cedarville University. The lake ranges in depth from 0.6-3.7m, is 140m by 150m across, an approximate volume of 40,000 m3 and demonstrates normal capabilities to support fish and other life. There is, however, some concern over Cedar Lake’s level of productivity as undesirable algae blooms are common during warmer months. In October and November 2016 we began to assess the spatial and temporal variability of water ...


Cichlid Behavioral Ecology: Streams Of Costa Rica, Ali Saheb, Erfan Ranjbar, Shannon Dieffenderfer, yazmeen Almutairri, nicole williams-ugula, Ella Brook Gray, Adel Pereira 2017 GSU

Cichlid Behavioral Ecology: Streams Of Costa Rica, Ali Saheb, Erfan Ranjbar, Shannon Dieffenderfer, Yazmeen Almutairri, Nicole Williams-Ugula, Ella Brook Gray, Adel Pereira

Georgia State Undergraduate Research Conference

No abstract provided.


Student Perceptions Of A Project-Based Laboratory Environment, Montana Nowak, Nikita Burrows, Suazette Mooring 2017 Georgia State University

Student Perceptions Of A Project-Based Laboratory Environment, Montana Nowak, Nikita Burrows, Suazette Mooring

Georgia State Undergraduate Research Conference

No abstract provided.


Quantitative Evaluation Of Clinostomum Marginatum Distribution In The Fish Host (Perca Flavescens): Investigation Of The Impact On Functional Performance, Doiba KI Eshofonie, Precious Freeman 2017 Lynchburg College

Quantitative Evaluation Of Clinostomum Marginatum Distribution In The Fish Host (Perca Flavescens): Investigation Of The Impact On Functional Performance, Doiba Ki Eshofonie, Precious Freeman

Student Scholar Showcase

Doiba Eshofonie & Precious Freeman

Mentor: Takashi Maie

2017 Student Scholar Showcase

Quantitative evaluation of Clinostomum marginatum distribution in the fish host (Perca flavescens): Investigation of the impact on functional performance

Clinostomum marginatum is a trematode commonly found in freshwater fish. The adult C. marginatum stays in its definitive avian host’s mouth and throat. It releases eggs upon contact in water and the eggs hatch into a free-swimming miracidia, which infects an aquatic snail as the first intermediate host. The miracidia, then, develops into a cercaria and leaves the snail to find a fish as its second intermediate host. The ...


Inquiry Into Perilipin-5a Expression In Triacylglycerol Rich Vs Normal Fed Mouse Tissue, Kobi Agyepong 2017 Otterbein University

Inquiry Into Perilipin-5a Expression In Triacylglycerol Rich Vs Normal Fed Mouse Tissue, Kobi Agyepong

Honors Thesis Projects

The steep rise in both childhood and adult obesity over the past three decades has moved to the forefront of public consciousness in recent years. This development has generated a marked increase in general health awareness and lifestyle changes for a vast number of individuals, most notably in the form of increased physical activity and diet alterations. The latter point is especially salient in a biochemical context, because of the myriad factors that can result in “fat accumulation”. Chief among these factors is the Perilipin 5A gene, (known as PLIN5A) which encodes the protein Perilipin 5A of the Perilipin family ...


Investigating The Effects Of Pre-Laboratory Videos With Associated Questions On The Performance And Overall Laboratory Experience Of Organic Chemistry Students, Shareef Gamal Mohamed Kotb 2017 Merrimack College

Investigating The Effects Of Pre-Laboratory Videos With Associated Questions On The Performance And Overall Laboratory Experience Of Organic Chemistry Students, Shareef Gamal Mohamed Kotb

Health Sciences Student Work

Background: Teachers struggle communicating ideas to students (Moreno et al, 2001). One of the aspects of teaching that’s most concerning is when students experience cognitive overload: the total effort exerted by working memory to grasp new information (Mayer, et al, 2002). The educational community found that introducing multimedia in learning minimizes cognitive overload (Mayer, et al, 2002). Little research has related to undergraduate chemistry classes, specifically the relationship between organic chemistry pre-laboratory multimedia and student learning. Purpose: The purpose of this capstone is to investigate the subjective efficacy of integrating pre-laboratory videos for lab preparation in an undergraduate organic ...


Pulmonary Surfactant Fortified With Cath-2 As A Novel Therapy For Bacterial Pneumonia, Brandon J. Baer 2017 University of Western Ontario

Pulmonary Surfactant Fortified With Cath-2 As A Novel Therapy For Bacterial Pneumonia, Brandon J. Baer

Western Research Forum

Background: Bacterial pneumonia is a leading cause of death worldwide, with high mortality rates persisting even after antibiotic treatment. Current treatments for pneumonia involve administration of antibiotics, however after the bacteria are killed they release toxic substances that induce inflammation and lung dysfunction. Host defense peptides represent a potential solution to this problem through their ability to down regulate inflammation. However, effective delivery to the lung is difficult because of the complex branching structure of the airways. My study addresses this delivery problem by using exogenous surfactant, a pulmonary delivery vehicle capable of improving spreading of these peptides throughout the ...


Assessment Of Olfactory-Based Social Recognition: Designing A Paradigm For Marmosets, Stephanie Womack 2017 University of Nebraska at Omaha

Assessment Of Olfactory-Based Social Recognition: Designing A Paradigm For Marmosets, Stephanie Womack

Student Research and Creative Activity Fair

Navigation of the social world depends largely on one’s responsiveness to social stimuli and information from a wide range of senses can be used to discriminate between individuals. Mammals use several sensory modes to communicate and respond to their surroundings, but olfaction is the dominant sense across most species. Chemosignals provide a wealth of information including sex, age, reproductive status, and individual identity. Currently, assessment of olfaction is largely limited to the habituation-dishabituation paradigm or the two-choice discrimination task used primarily in rodents. These paradigms are limited by their reliance on inherent reward of interaction with stimuli without providing ...


Gait Biomechanics In Patients With Peripheral Artery Disease After Revascularization, Sarah Baker 2017 University of Nebraska at Omaha

Gait Biomechanics In Patients With Peripheral Artery Disease After Revascularization, Sarah Baker

Student Research and Creative Activity Fair

Peripheral artery disease (PAD) is a cardiovascular disease manifesting blockages to arteries while limiting blood flow to the legs. Patients with PAD have pain/tingling in calves, thighs, and/or buttocks emanating by physical activity called intermittent claudication. PAD causes physical function limitations and increases cardiovascular morbidity by 3-6 times. PAD becomes particularly more prevalent with age. Patients with PAD walk differently than their healthy counterparts. Surgical revascularization to restore blood flow is the typical intervention, but whether walking patterns are restored following surgery has not been studied. This study compared walking patterns of patients with PAD at baseline and ...


Associations Of Health Club Membership With Physical Activity And Cardiovascular Health, Elizabeth C. Schroeder, Gregory Welk, Warren D. Franke, Duck-Chul Lee 2017 University of Illinois at Chicago

Associations Of Health Club Membership With Physical Activity And Cardiovascular Health, Elizabeth C. Schroeder, Gregory Welk, Warren D. Franke, Duck-Chul Lee

Duck-Chul Lee

Introduction This study evaluates whether a health club membership is associated with meeting the US physical activity (PA) guidelines and/or favorable cardiovascular health.

Methods Using cross-sectional data of health club members (n = 204) and non-members (n = 201) from April to August 2013, this is the first study to our knowledge to examine a health club membership in relation to objectively measured cardiovascular health indicators including resting blood pressure, resting heart rate, body mass index, waist circumference, and cardio respiratory fitness based on a non-exercise test algorithm. To determine the total PA and sedentary time, this study used a comprehensive ...


Associations Of Health Club Membership With Physical Activity And Cardiovascular Health, Elizabeth C. Schroeder, Gregory Welk, Warren D. Franke, Duck-Chul Lee 2017 University of Illinois at Chicago

Associations Of Health Club Membership With Physical Activity And Cardiovascular Health, Elizabeth C. Schroeder, Gregory Welk, Warren D. Franke, Duck-Chul Lee

Kinesiology Publications

Introduction This study evaluates whether a health club membership is associated with meeting the US physical activity (PA) guidelines and/or favorable cardiovascular health.

Methods Using cross-sectional data of health club members (n = 204) and non-members (n = 201) from April to August 2013, this is the first study to our knowledge to examine a health club membership in relation to objectively measured cardiovascular health indicators including resting blood pressure, resting heart rate, body mass index, waist circumference, and cardio respiratory fitness based on a non-exercise test algorithm. To determine the total PA and sedentary time, this study used a comprehensive ...


Annotation And Identification Of Several Glycerolipid Metabolic Related Ortholog Genes; Mrub_0437, Mrub_1813 And Mrub_2759 In The Organism Meithermus Ruber And Their Predicted Respective Orthologs B3926, B4042 And Bo514 Found In E.Coli., Abdul Rahman Abdul Kader, Dr. Lori R. Scott 2017 Augustana College, Rock Island Illinois

Annotation And Identification Of Several Glycerolipid Metabolic Related Ortholog Genes; Mrub_0437, Mrub_1813 And Mrub_2759 In The Organism Meithermus Ruber And Their Predicted Respective Orthologs B3926, B4042 And Bo514 Found In E.Coli., Abdul Rahman Abdul Kader, Dr. Lori R. Scott

Meiothermus ruber Genome Analysis Project

We predict Mrub_0437 encodes the enzyme glycerol kinase (DNA coordinates [417621..419183), which is an intermediary step of the glycerolipid metabolic pathway (KEGG map00561), It catalyzes the conversion of glycerol to sn-Glycerol-3-phosphate. The E. coli K12 MG1655 ortholog is predicted to be b3926.

We predict Mrub_1813 encodes the enzyme diacylglycerol kinase (DNA coordinates [1864659..1865063), which is an intermediary step of the glycerolipid metabolic pathway (KEGG map00561), It catalyzes the conversion of 1,2-diacyl-sn-glycerol to 1,2-diacyl-sn-glycerol 3-phosphate. The E. coli K12 MG1655 ortholog is predicted to be b4042.

We predict Mrub_2759 encodes the enzyme glycerol kinase (DNA coordinates [2799712 ...


Ionic Regulation Of Critical Cellular Processes In Non-Excitable Cells, Brandon M. Franklin 2017 University of Kentucky

Ionic Regulation Of Critical Cellular Processes In Non-Excitable Cells, Brandon M. Franklin

Theses and Dissertations--Biology

There are long-standing hypotheses that endogenous ion currents act to control cell dynamics in development, wound healing and regeneration. However, the mechanisms employed by cells to detect the electric field (EF) and translate it into a discernable message to drive specific cell behaviors, such as migration, proliferation and differentiation, are not well understood. A better understanding of how cells are able to sense EFs and react to them is vital to understanding physiological mechanisms are involved in regeneration. Ion channel signaling provides a reasonable suspect for mediating these effects based on their documented involvement in proliferation, migration and differentiation.

To ...


Id4 And Fkbp52 Interaction Regulates Androgen Receptor Activity: Mechanistic Insight, Jugal Bharat Joshi 2016 Clark Atlanta University

Id4 And Fkbp52 Interaction Regulates Androgen Receptor Activity: Mechanistic Insight, Jugal Bharat Joshi

Electronic Theses & Dissertations Collection for Atlanta University & Clark Atlanta University

The inhibitor of DNA binding protein 4 (ID4) is a dominant negative regulator of basic helix loop helix (bHLH) family of transcription factors.1 Recently, Patel et al., demonstrated that inhibitor of differentiation 4 (ID4) acts as a tumor suppressor and its loss, frequently observed in prostate cancer, promotes castration-resistant prostate cancer (CRPC) through constitutive androgen receptor (AR) activation.2 However, the mechanism by which loss of ID4 promotes constitutively active AR signaling in the CRPC conditions is unknown. The rationale of the present study was to unravel the underlying molecular mechanisms through which loss of ID4 potentiates AR signaling ...


Examining The Combined Effects Of Dissolved Oxygen, Temperature, And Body Size On The Physiological Responses Of A Model Macrobenthic Polychaete Species, Capitella Teleta, Kelsey Burns Gillam 2016 University of Southern Mississippi

Examining The Combined Effects Of Dissolved Oxygen, Temperature, And Body Size On The Physiological Responses Of A Model Macrobenthic Polychaete Species, Capitella Teleta, Kelsey Burns Gillam

Dissertations

While the scientific community is in consensus that coastal systems are threatened by climate change, few climate change studies test the effects of more than one variable directly related to climate change. The dissolved oxygen (DO) levels of the ocean are currently subject to both global warming and eutrophication; 94% of all hypoxia zones are expected to experience >2°C increase by 2035. This dissertation aims to examine how a model organism responds to simultaneous thermal and DO stress involving four levels of DO (100%, 70%, 50%, and 20%) saturation and three temperatures (15°C, 20°C, and 25°C ...


Effects Of Synthetic Turf And Shockpads On Impact Attenuation Related Biomechanics During Drop Landing, Hang Qu 2016 University of Tennessee, Knoxville

Effects Of Synthetic Turf And Shockpads On Impact Attenuation Related Biomechanics During Drop Landing, Hang Qu

Masters Theses

Synthetic turf has been widely utilized in sports since 1964. Discrepancies, however, in injury incidence on synthetic turf and natural grass have been reported throughout studies. Adding a shock pad under synthetic turf carpet is claimed to aid in energy absorption and decrease impact loading. Although some studies have conducted materials tests and compared mechanical characteristics of synthetic turf with different shock pads, no studies have examined biomechanical characteristics of impact related human movements on an infilled synthetic turf system with different underlying shock pads. The purpose of this research was to investigate effects of an infilled synthetic turf with ...


Distribution Of Major And Minor Elements In The Surface Water Of Southern Ocean Near East Antarctica, Pawan K. Bharti Dr., Bhupesh Sharma, R. K. Singh, Narendra Pal, A. K. Tyagi 2016 Gurukul University, Haridwar

Distribution Of Major And Minor Elements In The Surface Water Of Southern Ocean Near East Antarctica, Pawan K. Bharti Dr., Bhupesh Sharma, R. K. Singh, Narendra Pal, A. K. Tyagi

Dr. Pawan Kumar Bharti

Distribution of major and minor element concentrations in Antarctic surface seawater samples was evaluated. Seawater samples were collected from eight sampling location in Southern Ocean from latitude S 67º16´10.9´´ and longitude E 28º39´64.5´´ to latitude S 69º17´42.9´´ and longitude E 76º13´23.3´´ and analyzed for various heavy metals like copper (Cu), lead (Pb), cadmium (Cd), zinc (Zn), nickel (Ni), chromium (Cr). The concentrations of heavy metals Cu, Pb, Cd, Zn, Ni, Cr and other major elements like sodium, potassium, calcium, magnesium, boron were measured in selected seawater samples using Inductively Coupled Plasma Optical ...


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