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Recent Articles in Systems Biology
A Compendium Of Caenorhabditis Elegans Rna Binding Proteins Predicts Extensive Regulation At Multiple Levels, Alex M. Tamburino, Sean P. Ryder, Albertha J. M. Walhout 
University of Massachusetts Medical School
A Compendium Of Caenorhabditis Elegans Rna Binding Proteins Predicts Extensive Regulation At Multiple Levels, Alex M. Tamburino, Sean P. Ryder, Albertha J. M. Walhout
Program in Systems Biology Publications and Presentations
Gene expression is regulated at multiple levels, including transcription and translation, as well as mRNA and protein stability. Although systems-level functions of transcription factors and microRNAs are rapidly being characterized, few studies have focused on the posttranscriptional gene regulation by RNA binding proteins (RBPs). RBPs are important to many aspects of gene regulation. Thus, it is essential to know which genes encode RBPs, which RBPs regulate which gene(s), and how RBP genes are themselves regulated. Here we provide a comprehensive compendium of RBPs from the nematode Caenorhabditis elegans (wRBP1.0). We predict that as many as 887 (4.4 ...
Pro-Asthmatic Cytokines Regulate Unliganded And Ligand-Dependent Glucocorticoid Receptor Signaling In Airway Smooth Muscle, Aihua Hu, Maureen B. Josephson, Barry L. Diener, Gustavo Nino, Shuyun Xu, Chinmay Paranjape, Jordan S. Orange, Michael M. Grunstein 
Himmelfarb Health Sciences Library, The George Washington University
Pro-Asthmatic Cytokines Regulate Unliganded And Ligand-Dependent Glucocorticoid Receptor Signaling In Airway Smooth Muscle, Aihua Hu, Maureen B. Josephson, Barry L. Diener, Gustavo Nino, Shuyun Xu, Chinmay Paranjape, Jordan S. Orange, Michael M. Grunstein
Integrative Systems Biology Faculty Publications
No abstract provided.
Effect Of Cotesia Rubecula (Hymenoptera: Braconidae) On Survival Of Larval Cohorts Of Pieris Rapae (Lepidoptera: Pieridae) On Collards: Evaluation Of The Impact Of An Introduced Biological Control Agent, Megan V. Herlihy 
University of Massachusetts - Amherst
Effect Of Cotesia Rubecula (Hymenoptera: Braconidae) On Survival Of Larval Cohorts Of Pieris Rapae (Lepidoptera: Pieridae) On Collards: Evaluation Of The Impact Of An Introduced Biological Control Agent, Megan V. Herlihy
Megan V Herlihy
Survival of artificially established cohorts of larvae of the imported cabbageworm, Pieris rapae (L.), was assessed in a collard (Brassica oleracea L., var. acephala) patch on an organic vegetable farm in western Massachusetts. We recorded a significant drop in survival of larvae between the 4th and 5th instar due to parasitism by the biological control agent Cotesia rubecula (Marshall), which was introduced to New England from China in 1988. This was a large change from the survivorship pattern of P. rapae observed in the same area in a previous study in 1985-1986, in which there was a significant drop in ...
Interactions Between Pieris Oleracea And Pieris Rapae (Lepidoptera: Pieridae) Butterflies, And The Biological Control Agents Cotesia Glomerata And Cotesia Rubecula (Hymenoptera: Braconidae)., Megan V. Herlihy University of Massachusetts - Amherst
Interactions Between Pieris Oleracea And Pieris Rapae (Lepidoptera: Pieridae) Butterflies, And The Biological Control Agents Cotesia Glomerata And Cotesia Rubecula (Hymenoptera: Braconidae)., Megan V. Herlihy
Megan V Herlihy
Pieris oleracea, formerly Pieris napi, was once a widespread pierid butterfly in New England until the introduction of a biological control agent, Cotesia glomerata. It has been suggested that C. glomerata is responsible for the range reduction of P. oleracea. There are been several introductions of a second more specialized biological control agent, Cotesia rubecula, to the United States since the 1960’s. My first goal was to determine the current distribution and status of P. rapae parasitoids and the effectiveness of C. rubecula as a biological control agent since its release. The findings of a survey I conducted of ...
An Integrated Encyclopedia Of Dna Elements In The Human Genome, Ian Dunham, Ewan Birney, Bryan R. Lajoie, Amartya Sanyal, Xianjun Dong, Melissa Greven, Xinying Lin, Jie Wang, Troy W. Whitfield, Jiali Zhuang, Job Dekker, Zhiping Weng, Gaurav Jain, ENCODE Project Consortium University of Massachusetts Medical School
An Integrated Encyclopedia Of Dna Elements In The Human Genome, Ian Dunham, Ewan Birney, Bryan R. Lajoie, Amartya Sanyal, Xianjun Dong, Melissa Greven, Xinying Lin, Jie Wang, Troy W. Whitfield, Jiali Zhuang, Job Dekker, Zhiping Weng, Gaurav Jain, Encode Project Consortium
Program in Systems Biology Publications and Presentations
The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of transcription, transcription factor association, chromatin structure and histone modification. These data enabled us to assign biochemical functions for 80% of the genome, in particular outside of the well-studied protein-coding regions. Many discovered candidate regulatory elements are physically associated with one another and with expressed genes, providing new insights into the mechanisms of gene regulation. The newly identified elements also show a statistical correspondence to sequence ...
Differential Activity Of The Kras Oncogene By Method Of Activation: Implications For Signaling And Therapeutic Intervention, Nathan Ihle 
Texas Medical Center Library
Differential Activity Of The Kras Oncogene By Method Of Activation: Implications For Signaling And Therapeutic Intervention, Nathan Ihle
UT GSBS Dissertations and Theses (Open Access)
Despite having been identified over thirty years ago and definitively established as having a critical role in driving tumor growth and predicting for resistance to therapy, the KRAS oncogene remains a target in cancer for which there is no effective treatment. KRas is activated b y mutations at a few sites, primarily amino acid substitutions at codon 12 which promote a constitutively active state. I have found that different amino acid substitutions at codon 12 can activate different KRas downstream signaling pathways, determine clonogenic growth potential and determine patient response to molecularly targeted therapies. Computer modeling of the KRas structure ...
The Nonconsumptive And Consumptive Effects Of The Invasive Green Crab (Carcinus Maenas) On Macroinfaunal Diversity, Abundance And Ecosystem Functioning In A New England Salt Marsh, Genevieve Bernatchez 
Northeastern University
The Nonconsumptive And Consumptive Effects Of The Invasive Green Crab (Carcinus Maenas) On Macroinfaunal Diversity, Abundance And Ecosystem Functioning In A New England Salt Marsh, Genevieve Bernatchez
Biology Master's Theses
Traditional studies of trophic cascades have revealed how predators by limiting abundance of their prey, have positive indirect effects on basal resources. However, recent studies have shown that predators can also indirectly affect such resources without consuming their prey by way of anti-predator foraging adaptive behavior (nonconsumptive effects). For example, on rocky shores, waterborne risk cues from the predatory green crab (Carcinus maenas) cause strong trophic cascades by suppressing the grazing rate of the herbivorous snail, Littorina littorea, on algal resources. L. littorea is also an abundant herbivore in northern New England salt marshes but it is unknown whether C ...
Interactions Between Pieris Oleracea And Pieris Rapae (Lepidoptera: Pieridae) Butterflies, And The Biological Control Agents Cotesia Glomerata And Cotesia Rubecula (Hymenoptera: Braconidae)., Megan V. Herlihy University of Massachusetts - Amherst
Interactions Between Pieris Oleracea And Pieris Rapae (Lepidoptera: Pieridae) Butterflies, And The Biological Control Agents Cotesia Glomerata And Cotesia Rubecula (Hymenoptera: Braconidae)., Megan V. Herlihy
Megan V Herlihy
Pieris oleracea, formerly Pieris napi, was once a widespread pierid butterfly in New England until the introduction of a biological control agent, Cotesia glomerata. It has been suggested that C. glomerata is responsible for the range reduction of P. oleracea. There are been several introductions of a second more specialized biological control agent, Cotesia rubecula, to the United States since the 1960’s. My first goal was to determine the current distribution and status of P. rapae parasitoids and the effectiveness of C. rubecula as a biological control agent since its release. The findings of a survey I conducted of ...
Are We Seeking Pimatisiwin Or Creating Pomewin? Implications For Water Policy, Patti LaBoucane-Benson, Ginger Gibson, Allen Benson, Greg Miller 
Western University
Are We Seeking Pimatisiwin Or Creating Pomewin? Implications For Water Policy, Patti Laboucane-Benson, Ginger Gibson, Allen Benson, Greg Miller
The International Indigenous Policy Journal
The purpose of this discussion is to describe the worldview and sacred relationship of the Cree people in Alberta, as well as how colonial policy has created despair (pomewin) in Aboriginal communities and a state of disconnectedness from the water. It concludes with the presentation of a framework for the development of policies that seek to repair the relationship between Aboriginal people and mainstream society – with the potential to create the good life, broadly defined (pimatisiwin) for all Albertans (Aboriginal and non-Aboriginal). This discussion is based upon the findings of a three-year research project entitled “The Sacred Relationship”. The goals ...
The Breathing Of The Bays, Jamie Vaudrey, Margaret (Peg) A. Van_Patten (editor) 
University of Connecticut
The Breathing Of The Bays, Jamie Vaudrey, Margaret (Peg) A. Van_Patten (Editor)
Wrack Lines
Bays in Long Island Sound and beyond have natural rhythms like breathing. Stress can impact the health of these natural ecosystems. While Long Island Sound has been examined for the extent of hypoxia in the summer, small embayments have not been examined carefully. In this article, two researchers investigate the oxygen, or lack of, in small bays of Long Island Sound.
List Of Thylakoid Zinc-Finger Proteins In Arabidopsis, Yan Lu 
Western Michigan University
List Of Thylakoid Zinc-Finger Proteins In Arabidopsis, Yan Lu
Yan Lu
No abstract provided.
Popular Institutions
Popular Authors
Connie Reimers-Hild
University of Nebraska - Lincoln
Bryan Lajoie
University of Massachusetts Medical School
Job Dekker
University of Massachusetts Medical School
Xianjun Dong
University of Massachusetts Medical School
Zhiping Weng
University of Massachusetts Medical School
Melissa Greven
University of Massachusetts Medical School
Jie Wang
University of Massachusetts Medical School
Xinying Lin
University of Massachusetts Medical School
Amartya Sanyal
University of Massachusetts Medical School
Troy Whitfield
University of Massachusetts Medical School
Based on downloads this month
Popular Articles
Sustainability Through Profitability: The Triple Bottom Line, Connie Reimers-Hild
An Integrated Encyclopedia Of Dna Elements In The Human Genome, Zhiping Weng, Job Dekker, Bryan Lajoie, Troy Whitfield, Xianjun Dong, Amartya Sanyal, Gaurav Jain, Jie Wang, Melissa Greven, Xinying Lin, Jiali Zhuang
Caffeine Metabolism And Cytochrome P450 Enzyme Mrna Expression Levels Of Genetically Diverse Inbred Mouse Strains, Michael Malfatti, Neal Addicott, Gabriela Loots
Understanding Acquired Resistance To Lapatinib In Breast Cancer Cells, Jen-Te Tseng
Synthesis, Characterisation And Biological Activity Of Transition Metal Complexes Of Thiabendazole
The Economic Effects Of Ski Resorts On Communities In The State Of Maine
Dynamic Vertical Climbing: Bioinspiration, Design, And Analysis, Goran Lynch
Are We Seeking Pimatisiwin Or Creating Pomewin? Implications For Water Policy, Patti LaBoucane-Benson
San Antonio High School Food Justice Program: A Handbook And Evaluation Of Edible Education, Katherine Tenneson
Based on downloads this month