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Genistein Affects Her2 Protein Concentration, Activation And Promoter Regulation Via Estrogen Receptor-And Non-Estrogen Receptor-Mediated Mechanisms, Mary S. Sakla, Pete J. Ansell, Nader S. Shenouda, Dennis B. Lubahn, Ruth S. MacDonald 2017 University of Missouri

Genistein Affects Her2 Protein Concentration, Activation And Promoter Regulation Via Estrogen Receptor-And Non-Estrogen Receptor-Mediated Mechanisms, Mary S. Sakla, Pete J. Ansell, Nader S. Shenouda, Dennis B. Lubahn, Ruth S. Macdonald

Ruth S. MacDonald

The HER2 proto-oncogene, a member of the epidermal growth factor receptor family, is overexpressed in 20–30% of breast cancers. Genistein, the main soy isoflavone, interacts with estrogen receptors (ER) and it is also a potent tyrosine kinase inhibitor. Previously, our laboratory found that genistein delayed mammary tumor onset in transgenic mice that overexpress HER2 gene. Our goal was to define the mechanism through which genistein affects mammary tumorigenesis inHER2 overexpressing mice. We hypothesized that genistein inhibits HER2 activation and expression through ER-dependent and ER-independent mechanisms. Genistein inhibited total HER2 protein expression and tyrosine phosphorylation in BT-474, an ERα (−) and ...


Phytosterol Pygeum Africanum Regulates Prostate Cancer In Vitro And In Vivo, Nader S. Shenouda, Mary S. Sakla, Leslie G. Newton, Cynthia Besch-Williford, Norman M. Greenberg, Ruth S. MacDonald, Dennis B. Lubahn 2017 University of Missouri

Phytosterol Pygeum Africanum Regulates Prostate Cancer In Vitro And In Vivo, Nader S. Shenouda, Mary S. Sakla, Leslie G. Newton, Cynthia Besch-Williford, Norman M. Greenberg, Ruth S. Macdonald, Dennis B. Lubahn

Ruth S. MacDonald

Background

Prostate cancer is an important public health problem. It is an excellent candidate disease for chemo-prevention because prostate cancer is typically slow growing and is usually diagnosed in elderly males. Pygeum africanum (Prunus africana or Rosaceae) is an African prune (plum) tree found in tropical Africa. An extract from the bark of Pygeum africanum has been used in Europe as a prevention and treatment of prostate disorders including benign prostatic hypertrophy (BPH). More recently in the USA, the phytotherapeutic preparations of Pygeum africanum and Saw palmetto have been marketed for prostate health including prostate cancer prevention and treatment.

Methods ...


Soy Isoflavones Have An Antiestrogenic Effect And Alter Mammary Promoter Hypermethylation In Healthy Premenopausal Women1, Wenyi Qin, Weizhu Zhu, Huidong Shi, John E. Hewett, Rachel L. Ruhlen, Ruth S. MacDonald, George E. Rottinghaus, Yin-Chieh Chien, Edward R. Sauter 2017 University of Missouri School of Medicine

Soy Isoflavones Have An Antiestrogenic Effect And Alter Mammary Promoter Hypermethylation In Healthy Premenopausal Women1, Wenyi Qin, Weizhu Zhu, Huidong Shi, John E. Hewett, Rachel L. Ruhlen, Ruth S. Macdonald, George E. Rottinghaus, Yin-Chieh Chien, Edward R. Sauter

Ruth S. MacDonald

We hypothesized that soy isoflavones would have dose related estrogenic and methylation effects. 34 healthy premenopausal women were prospectively enrolled and randomized in double-blind fashion to receive either 40 mg or 140 mg isoflavones daily through one menstrual cycle. Breast specific (NAF) and systemic (serum) estrogenic effects were assessed measuring the estrogenic marker complement (C)3 and changes in cytology, while methylation effects were evaluated in mammary ductoscopy (MD) specimens using methylation specific PCR assessment of five genes (p16, RASSF1A, RARβ2, ER, and CCND2) associated with breast carcinogenesis. Serum genistein significantly increased post treatment in women consuming both isoflavone doses ...


Chloroquine-Inducible Par-4 Secretion Is Essential For Tumor Cell Apoptosis And Inhibition Of Metastasis, Ravshan Burikhanov, Nikhil Hebbar, Sunil K. Noothi, Nidhi Shukla, James Sledziona, Nathália Araujo, Meghana Kudrimoti, Qing Jun Wang, David S. Watt, Danny R. Welch, Jodi Maranchie, Akihiro Harada, Vivek M. Rangnekar 2017 University of Kentucky

Chloroquine-Inducible Par-4 Secretion Is Essential For Tumor Cell Apoptosis And Inhibition Of Metastasis, Ravshan Burikhanov, Nikhil Hebbar, Sunil K. Noothi, Nidhi Shukla, James Sledziona, Nathália Araujo, Meghana Kudrimoti, Qing Jun Wang, David S. Watt, Danny R. Welch, Jodi Maranchie, Akihiro Harada, Vivek M. Rangnekar

Radiation Medicine Faculty Publications

The induction of tumor suppressor proteins capable of cancer cell apoptosis represents an attractive option for the re-purposing of existing drugs. We report that the anti-malarial drug, chloroquine (CQ), is a robust inducer of Par-4 secretion from normal cells in mice and cancer patients in a clinical trial. CQ-inducible Par-4 secretion triggers paracrine apoptosis of cancer cells and also inhibits metastatic tumor growth. CQ induces Par-4 secretion via the classical secretory pathway that requires the activation of p53. Mechanistically, p53 directly induces Rab8b, a GTPase essential for vesicle transport of Par-4 to the plasma membrane prior to secretion. Our findings ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Starling 2017 Trivedi Global Inc

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Starling

Susan Elizabeth Starling

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Peter Surguy 2017 Trivedi Global Inc

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Peter Surguy

Peter Lynwood Surguy

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Allen 2017 Trivedi Global Inc.

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Allen

Susan Mardis Allen

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Sara Friedman 2017 Selected Works

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Sara Friedman

Sara Friedman

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Steven Christie 2017 Selected Works

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Steven Christie

Steven Lee Christie

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Robert Kock 2017 U.S. Military Academy

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Robert Kock

Robert John Kock

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Su-Mei Liu 2017 Colorado Technical University

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Su-Mei Liu

Su-Mei Chen Liu

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Yusif Yamin 2017 Trivedi Global Inc.

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Yusif Yamin

Yusif Yamin

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Thomas Orban 2017 Trivedi Global Inc.

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Thomas Orban

Thomas Orban

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Sakina Aleemah Ansari 2017 Morgan State University

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Sakina Aleemah Ansari

Sakina Aleemah Ansari

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Victoria Vannes 2017 Rosemont College

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Victoria Vannes

Victoria Lee Vannes

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect® ) Based Herbomineral Formulation In Mouse Splenocytes, Russell Callas 2017 Trivedi Global Inc.

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect® ) Based Herbomineral Formulation In Mouse Splenocytes, Russell Callas

Russell Phillip Callas

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Jones 2017 Selected Works

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susan Jones

Susan Jones

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Rolando Piedad 2017 Selected Works

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Rolando Piedad

Rolando Baptista Piedad

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Tom Slade 2017 Trivedi Global Inc.

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Tom Slade

Tom Charles Slade

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susanne Wasmus 2017 Selected Works

Modulation Of Pro-Inflammatory Cytokines Expression Of The Biofield Energy Healing (The Trivedi Effect®) Based Herbomineral Formulation In Mouse Splenocytes, Susanne Wasmus

Susanne Kathrin Wasmus

With the increasing popularity of herbomineral preparations in healthcare, a new proprietary herbomineral formulation was formulated with ashwagandha root extract and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect®) on the herbomineral formulation using murine splenocyte cells. The test formulation was divided into two parts. One was the control without the Biofield Energy Treatment. The other part was labelled the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers. Through MTT assay, all the ...


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